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Anti-Macroh2a.1 / H2AFY Antibody [RM248] (ARG57240)

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Anti-Macroh2a.1 / H2AFY Antibody [RM248] (ARG57240) Product datasheet [email protected] ARG57240 Package: 50 μg anti-MacroH2A.1 / H2AFY antibody [RM248] Store at: -20°C Summary Product Description Rabbit Monoclonal antibody [RM248] recognizes MacroH2A.1 / H2AFY Tested Reactivity Hu Tested Application ICC/IF, WB Specificity This antibody reacts to the Core histone macro-H2A.1 (Histone macroH2A1) protein, independent of post-translational modifications. No cross reactivity with other histone proteins. Host Rabbit Clonality Monoclonal Clone RM248 Isotype IgG Target Name MacroH2A.1 / H2AFY Antigen Species Human Immunogen Synthetic peptide around the C-terminus of Human MacroH2A.1 / H2AFY. Conjugation Un-conjugated Alternate Names mH2A1; Medulloblastoma antigen MU-MB-50.205; H2A.y; MACROH2A1.1; Histone macroH2A1; H2A/y; macroH2A1.2; Histone H2A.y; H2AF12M; Core histone macro-H2A.1; H2AFJ Application Instructions Application table Application Dilution ICC/IF 1 - 2 µg/ml WB 0.5 - 2 µg/ml Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. Calculated Mw 40 kDa Properties Form Liquid Purification Purification with Protein A. Buffer PBS, 0.09% Sodium azide, 50% Glycerol and 1% BSA. Preservative 0.09% Sodium azide Stabilizer 50% Glycerol and 1% BSA Concentration 1 mg/ml www.arigobio.com 1/3 Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. Note For laboratory research only, not for drug, diagnostic or other use. Bioinformation Database links GeneID: 9555 Human Swiss-port # O75367 Human Gene Symbol H2AFY Gene Full Name H2A histone family, member Y Background Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Function Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation. [UniProt] Images ARG57240 anti-MacroH2A.1 / H2AFY antibody [RM248] ICC/IF image Immunofluorescence: HeLa cells stained with ARG57240 anti- MacroH2A.1 / H2AFY antibody [RM248] (red). Actin filaments have been labeled with fluorescein phalloidin (green). www.arigobio.com 2/3 ARG57240 anti-MacroH2A.1 / H2AFY antibody [RM248] WB image Western blot: Acid extracts from K562 cells, stained with ARG57240 anti-MacroH2A.1 / H2AFY antibody [RM248] at 1 µg/ml. www.arigobio.com 3/3 Powered by TCPDF (www.tcpdf.org).
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