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UPMC CancerCenter, partner with University of Cancer Institute VOL 9, NO. 1, 2014 NO. 9, VOL

INSIDE 10 Living a Legacy; Advancing a Cause | 14 Speaking Up for a Misunderstood Disease | 20 Remembering Ronald B. Herberman, MD

Soaring in the Face of Cancer The University of Pittsburgh Cancer Institute, working in conjunction with UPMC CancerCenter, UPMC’s clinical care delivery network, is western ’s only National Cancer Institute (NCI)-designated Comprehensive Cancer Center, reflecting the highest level of recognition by the NCI.

ON THE COVER Donald Trent (left), a patient of UPMC CancerCenter’s Mario Lemieux Center for Blood Cancers, with his brother, Larry, before a flight on Donald’s plane.

Cancer Discovery & Care is a publication of UPMC CancerCenter and the University of Pittsburgh Cancer Institute (UPCI) and is produced by UPMC Clinical Marketing. © Copyright 2014 UPMC. All rights reserved. No portion of this magazine may be reproduced without written permission. Send suggestions, comments, or address changes to Amyjo McDade at UPCI/UPMC CancerCenter, Office of Communications, UPMC Cancer Pavilion, 5150 Ave., Suite 1B, Pittsburgh, PA 15232, or via email at [email protected]. 4 10 14 20

UPMC CancerCenter and UPCI Executive Leadership ...... 2

Changing the Face of Cancer ...... 3 Director’s Message

Soaring in the Face of Cancer ...... 4

Expanding UPMC CancerCenter’s Global Footprint ...... 9

Living a Legacy, Advancing a Cause ...... 10

Providing a Good Night’s Rest ...... 12

Lung Cancer: Speaking up for a Misunderstood Disease ...... 14

Putting the “Fun” in Fundraising ...... 18

Breast Cancer: At the Forefront of Personalized Medicine ...... 19

Remembering Ronald B. Herberman, MD ...... 20

Community Events Prove to Be Strong Assets ...... 23

Faces of Hope: A Future Without Cancer ...... 24 2012 Hillman Cancer Center Gala

2012-2013 Donors ...... 25

News Briefs ...... 32

University of Pittsburgh Cancer Institute | 1 UPMC CancerCenter and University of Pittsburgh Cancer Institute (UPCI) Executive Leadership

Nancy E. Davidson, MD Peter G. Ellis, MD John Mucenski, PharmD Director, UPCI and UPMC CancerCenter Deputy Director, Clinical Services Regional Director, Pharmacy Operations Associate Chief Medical Officer, UPMC CancerCenter Stanley M. Marks, MD Joel Nelson, MD Chairman, UPMC CancerCenter Robert L. Ferris, MD, PhD, FACS Co-Leader, Prostate Cancer Program Associate Director, Translational Research, UPCI Chairman, Department of Urology Charles E. Bogosta, MBA Co-Leader, Cancer Immunology Program, UPCI President, UPMC CancerCenter Jennifer M. Raetz, MPA Michelle Fisher Reyes Director, Development K. Scott Baker Director, Advocacy and External Relations Vice President, UPMC Susan Schoonover UPMC Chief Government Relations Officer Research Manager, Surgical Oncology Susan Gibson, RN, BSN, MBA David Bartlett, MD Kimberly B. Schriver, MBA, MHA Senior Director, Hillman Cancer Center Vice Chairman, Surgical Oncology and Administrator, Division of Hematology-Oncology GI Surgical Services Jennifer Rubin Grandis, MD, FACS Shivendra V. Singh, PhD Leader, Head and Neck Cancer Program, UPCI Michael J. Becich, MD, PhD Associate Director, Basic Research, UPCI Associate Director, Cancer Informatics Lisa Haskins, RT (R)(T)(ARRT) Cheryl Steele, RN, MSN, MPM, AOCN Senior Director, Operations, Radiation Oncology Richard P. Bondi Director, Regulatory, Quality and Safety, Chief Financial Officer Maureen Hatch, MBA Medical Oncology Senior Director, Operations, Medical Oncology Dana Bovbjerg, PhD Scot Stevens Leader, Biobehavioral Medicine in Oncology Program Dwight E. Heron, MD, FACRO, FACR Chief Information Officer Director, Radiation Services, UPMC CancerCenter Director, Personalized Medicine Technology, UPMC Adam M. Brufsky, MD, PhD, FACP Chairman, Department of Radiation Oncology, Associate Chief, Division of Hematology Oncology Bennett Van Houten, PhD UPMC Shadyside Associate Director of Clinical Investigation, UPCI Co-Leader, Molecular and Cellular Cancer Pawel Kalinski, MD, PhD Biology Program, UPCI Edward Chu, MD Director of Research, Division of Surgical Deputy Director, UPCI Jennifer C. Yates Oncology, UPCI Chief, Division of Hematology-Oncology Manager, Media Relations Co-Leader, Molecular Therapeutics and Kelly B. Kassab, RT (R)(T), MHA Jian-Min Yuan, MD, PhD Drug Discovery Program, UPCI Vice President, Radiation Oncology Operations Associate Director, Cancer Control and Population Executive Administrator, Department of Deidre Cleary Sciences, UPCI Radiation Oncology Senior Director, Clinical Research Administration Co-Leader, Cancer Epidemiology, Prevention, Michael Keyes and Control Program Frank Czura, CPA Executive Director Director, Compliance and Privacy Karen Yuhas, RN, BSN, MBA The Regional Cancer Center Director, Central Billing Office Maryann Donovan, PhD, MPH Douglas J. Lucas Associate Director, Research Administration, UPCI Director, Marketing Stephanie K. Dutton, MPA, CMPE James D. Luketich, MD Chief Operating Officer Co-Director, Surgical Oncology Services Vice President, Medical Oncology Operations, Chairman, Department of Cardiothoracic Surgery UPMC CancerCenter Eric D. McIntosh Director, Human Resources

University of Pittsburgh Cancer Institute (UPCI) Council

Chair Nick DeIuliis William Isler The Honorable John R. Pippy Sy Holzer Joseph W. DeNardo William Kassling Jane Roesch Robert Denove Mario Lemieux Cynthia Roth Vice-Chair Douglas P. Dick Sally Levin Susan C. Santa-Cruz Elsie H. Hillman George A. Fechter Jeffrey Lipton Frederic B. Sargent Curtis Aiken Sr. Lee B. Foster II David Malone Dan Shapira Thomas Balestrieri John P. Friel Kevin McClatchy Robert Slagle G. Nicholas Beckwith III Chip Ganassi Susan P. McGalla Sandy Snyder James Broadhurst Thomas B. Grealish Katie McSorley Thomas VanKirk Carlos Cardoso Joseph Haleski Leslie Merrill The Honorable Jack Wagner Frank Coonelly Roy W. Haley John Weinstein Harriet Crawford I.N. Rendall Harper Eugene J. O’Sullivan Michael Zamagias Randall L. Crawford Mark Hart Arnold Palmer Barbara Crown Dawne Hickton Bradley Penrod

2 | UPMC CancerCenter Changing the Face of Cancer

In 1985, the University At the heart of Dr. Herberman’s legacy But our work is far from complete. The of Pittsburgh recruited at UPCI and UPMC CancerCenter are American Cancer Society estimates that Ronald B. Herberman, MD, those whom we serve: our patients. 1,660,290 people will have developed from the National Cancer Every day we meet remarkable men, cancer in the in 2013. Each of Institute to develop an women, and children who soar in the these individuals deserves the opportunity oncology research center. face of cancer. They challenge each of to soar in the face of his or her disease, His vision, energy, and persistence led to us to confront adversity directly and with and needs our ongoing support. All of us what is now known as the University of determination. Our magazine features at UPCI and UPMC CancerCenter look Pittsburgh Cancer Institute (UPCI), survivors who have reignited old passions forward to partnering with you as we western Pennsylvania’s only National and created new ones following treatment; advance the vision of Dr. Herberman to Cancer Institute-designated families who are creating lasting legacies make a meaningful impact on the Comprehensive Cancer Center, which in honor of loved ones affected by cancer; prevention and treatment of cancer. works in partnership with UPMC and physicians and researchers committed CancerCenter. to improving the treatment of cancer through new initiatives in all facets of Dr. Herberman passed away unexpectedly personalized cancer discovery and care. in May 2013, but as you will read in this issue of Cancer Discovery & Care, his With your support over the years, commitment to advancing cancer research UPCI and UPMC CancerCenter have and treatment continues not only at the changed the face of cancer in our region. University of Pittsburgh, but throughout Your generous investment of time, talent, our network of regional cancer centers and funds has allowed us to challenge and around the globe in Ireland, Italy, the way we view these diseases, unlocking Kazakhstan, and Singapore. innovative treatment options that are transforming medicine and extending — or even saving — lives, one at a time.

Nancy E. Davidson, MD

Director UPCI and UPMC CancerCenter

University of Pittsburgh Cancer Institute | 3 Soaring in the Face of Cancer

4 | UPMC CancerCenter Donald Trent

University of Pittsburgh Cancer Institute | 5 Soaring in the Face of Cancer

In the fall of 2004, Don Trent, a mechanical engineer for US Airways and a pilot since the age of 16, learned the true meaning of “life takes a detour.” Until that , he was living a hectic but happy life — working in a career that he loved, taking graduate courses, and spending time with his wife and two daughters, ages four and 10 months at the time. He maintained a healthy, active lifestyle, running and walking every day for exercise.

In October 2004, Don noticed a small lump on his A stem cell transplant requires administration of chemotherapy to scalp. As the weeks passed, the number of lumps kill cancer cells, followed by the infusion of healthy stem cells into increased. After the lumps became bothersome, he the body to replace diseased stem cells. It is a standard treatment for went to a surgeon to have them removed, who in turn certain blood cancers, including leukemia, myeloma, and lymphoma. sent his tissue samples to the lab for evaluation. After subsequent There are two commonly accepted and widely used types of stem testing Don was diagnosed with acute lymphocytic leukemia (ALL), cell transplantation: autologous and allogeneic. In an autologous a cancer of the blood and bone marrow that progresses rapidly transplant, the patient’s own stem cells are harvested prior to high and creates too many lymphocytes, a type of white blood cell. doses of chemotherapy, and then returned back into the patient after chemotherapy to help the immune system recover. During an Don spent most of 2005 receiving oral and intravenous allogeneic stem cell transplant, physicians collect and transplant chemotherapy treatment at Hillman Cancer Center under the stem cells from a donor who has compatible genetic markers on care of Dennis J. Meisner, MD, FACP, medical oncologist, UPMC their white blood cells — referred to as a human leukocyte antigen CancerCenter. After the physically and mentally demanding (HLA) match — to the patient. treatments, Don was able to return to work in late November 2005, almost a year to the date after his diagnosis. As his treatments A second birthday ended, he began to regain his stamina and strength. Don prepared for a stem cell transplant under the care of Mounzer A. Agha, MD, clinical director, Stem Cell Transplantation Program In November 2007, Don suffered a relapse. His next option for and director, Mario Lemieux Center for Blood Cancers at UPMC treatment was to undergo a stem cell transplant through the Stem CancerCenter. Although it was admittedly a scary decision for Don, Cell Transplantation Program of UPMC CancerCenter. he was grateful for his physician’s guidance and support.

An experienced program “Dr. Agha discussed the risks and benefits of the transplant process Approximately 150 stem cell transplants are done annually at and procedures. He straightforwardly explained what I was facing, the Stem Cell Transplantation Program of UPMC CancerCenter, and I decided to go for it,” said Don. the largest provider of stem cell transplantation services in western Pennsylvania. The stem cell transplantation team is comprised The search for a donor began immediately, starting with Don’s of health care professionals from various disciplines, including brother and sister. They underwent HLA testing, in which their medical and radiation oncologists, advanced practice providers, blood was drawn and tested to determine if they were compatible. nurses, psychologists, pharmacists, dietitians, physical therapists, Fortunately for Don and his family, they didn’t have to wait long and social workers. The team works to develop and deliver for a donor, as it was determined his brother, Larry Trent, was a stem cell transplantation therapies for adults with cancer and compatible match. non-cancerous disorders, and collaborates to determine each individual patient’s course of treatment. In addition, investigators In February 2008, Don was admitted into UPMC Shadyside, in the program are focused on improving the effectiveness of where he received high doses of chemotherapy in preparation for transplants in patients, reducing or eliminating potentially harmful his allogeneic stem cell transplant. On February 19, he received side effects that may be associated with a transplant, and using his transplant from Larry. a patient’s stem cells to treat their disease.

6 | UPMC CancerCenter “We all call February 19 my ‘second birthday.’ Now, I celebrate it every year.”

Donald Trent

“My brother and I have always had a good relationship, but it is make yourself get up every morning, put your feet on the floor, even more special now post-transplant. I am forever grateful and and determine that you will not surrender to self-defeat. Do not honored that God chose my brother to give me a second chance lose hope, and hold tight to the promises of your faith.” at life,” said Don. The Mario Lemieux Center for Blood Cancers: After the transplant, the stem cell staff continued to care for Don, A seamless transition testing his blood to track progress and make sure his immune As a patient of the Stem Cell Transplantation Program of UPMC system recovered. Although the recovery was long and took a CancerCenter, Don felt like he was in the best hands and receiving physical and emotional toll on Don, little by little he made progress. the best care possible to combat his aggressive disease. In January Throughout, he tried to remain positive with the help of his family, 2013, UPMC CancerCenter, in partnership with University of Pittsburgh friends, faith, and cancer care team. In early 2009, Don was able to Cancer Institute (UPCI), seamlessly transitioned the Stem Cell return to work, restoring a sense of normalcy in his life. Transplantation Program onto the fourth floor of Hillman Cancer Center with the opening of the Mario Lemieux Center for Blood Cancers. “I have a first-hand understanding of the trials and struggles one must go through during a critical illness, and profound respect Reinforcing the already strong commitment and resources of the Stem for all the caregivers who provide that much-needed lifeline of Cell Transplantation Program, the new center accommodates patients’ support,” said Don. “I know that life will never be the same again, needs for flexibility and provides easier access to the latest blood but I embrace the ‘new life’ with which I have been blessed and cancer therapies and clinical trials. Funded in part by gifts from the challenges and opportunities that lie ahead.” the Mario Lemieux Foundation, the Hillman Foundation, and the Henry L. Hillman Foundation, the center provides outpatient treatments, It has been more than five years since his transplant, and Don is including biologic therapy, chemotherapy, cord blood transplantation, doing well. He is back to exercising regularly, and in the few years radiation therapy, and stem cell transplantation, for patients with following his transplant, he and his two daughters took up skiing, blood cancers and other types of blood disorders. a new hobby. In 2011, Don returned to flying — his passion — with family and friends. He continues to share his story in hopes An environment of hope and comfort of helping those going through a similar journey. “The vision for the Mario Lemieux Center for Blood Cancers “I would like to encourage anyone facing a critical illness to surround came to us because we wanted to establish a unique patient themselves with family, friends, and the new friends you will meet experience,” said Dr. Agha. “We changed the care model as you go through your treatments. Even when you don’t want to, completely, so patients can relax and feel like they are our priority from the moment they walk onto the floor.”

University of Pittsburgh Cancer Institute | 7 Soaring in the Face of Cancer

patient experiences with an “edutainment” system that combines entertainment and relevant health care information. This system gives patients access to television shows, movies, news, information about their health condition, and more.

Personalized medicine through research collaboration Dedicated to delivering more effective, safe, efficient, and individualized care, the center has implemented a new care model. With UPCI’s groundbreaking research and the latest information management technologies essential for personalized medicine at the centerpiece, the clinical team, which includes researchers, meets with a patient as a group to offer new protocols that fit their diagnosis, giving the patient an opportunity to explore more To accomplish this, the center was designed to give patients and options, a key for the center. With the variety of clinical trials families a comfortable and tranquil healing environment. Instead available, the center is on track to become a top research program of a waiting area, patients are directed to private, calm exam rooms, for blood cancers. where everything from registration to check out is done. Instead of sitting on a traditional exam table, patients relax in a recliner “The Mario Lemieux Center for Blood Cancers and UPMC as they talk with their doctors, have blood drawn, and review their CancerCenter provides physicians with a state-of-the-art facility test results. that helps them take care of patients in an excellent way,” said Dr. Agha. “But, it also provides the patients and their families with Upon exiting the elevators, patients and visitors are greeted with a personal environment that helps them go through what can be natural light, calming earth tones, and natural surfaces, giving a very trying and difficult process.” the open and airy space a spa-like feel. While there, patients and their family members can take a break from their visit and enjoy the outside terrace, with seating, shade, and a putting green, For more information about the Stem Cell Transplantation Program designed by Nathalie Lemieux, vice president of the Mario Lemieux at UPMC CancerCenter or to take a virtual tour of the Mario Lemieux Foundation. In addition, the center is paving the way for improved Center for Blood Cancers, visit UPMCCancerCenter.com/OneTeam.

Program Recognized for Dedication to Patient Needs and High Standards of Care

The Stem Cell Transplantation Program therapy products collected and processed at UPMC CancerCenter has been awarded with rigorous controls. FACT officials a three-year re-accreditation by the then visited the Mario Lemieux Center for said Stanley Marks, MD, director of Foundation for the Accreditation of Cellular Blood Cancers to administer an on-site clinical services and chief medical Therapy (FACT), reflecting the program’s inspection of the program’s staff and officer of UPMC CancerCenter, chief of commitment to quality clinical care and processes. Re-accreditation was awarded the division of hematology/oncology at laboratory practice in cellular therapy. effective July 2013. UPMC Shadyside, and clinical professor of medicine at the University of Pittsburgh To receive re-accreditation, program “FACT’s re-accreditation of the Stem School of Medicine. “We are extremely leadership submitted an application that Cell Transplantation Program is external excited to be recognized again by such a successfully demonstrated its acceptance validation of what we strive for — the prestigious organization.” and adherence to FACT’s strict standards, quality and excellence of our services to which emphasize the clinical use of cellular provide the best benefit to our patients,”

8 | UPMC CancerCenter EXPANDING UPMC CANCERCENTER’S GLOBAL FOOTPRINT

Sweden For more than two decades, UPMC CancerCenter Ireland Dublin Denmark has been recognized as a leader in cancer care Waterford United delivery and research throughout western Kingdom Pennsylvania. With that solid foundation, UPMC Netherlands Poland has been actively involved in establishing and Belgium Germany managing several facilities around the world in

Czech order to meet the needs of international patients. Republic

Ireland France Switzerland The first of the international cancer centers was the UPMC Austria Whitfield Cancer Centre in Waterford, Ireland. A year after its opening in 2006, UPMC assumed management responsibilities Italy of the cancer center at Beacon Hospital, Dublin. The radiosurgery program at UPMC Beacon Hospital was recently recognized for Spain excellence in delivering stereotactic radiosurgery treatment. Rome

Italy UPMC manages the UPMC San Pietro Fatebenefratelli (FBF) Advanced Radiotherapy Center in Rome, Italy, which offers stereotactic radiosurgery via the same state-of-the-art platform operating in the Mary Hillman Jennings Radiation Oncology Center at UPMC Shadyside in Pittsburgh. The facility fulfills an unmet need for advanced radiotherapy treatment options and promotes UPMC’s recognition among the international scientific Russia and academic community. Russia Astana Kazakhstan Nazarbayev University in Kazakhstan selected UPMC in 2012 to conduct a study related to the development of a national oncology KAZAKHSTAN treatment and research. The university and local government have since extended the relationship with UPMC to include assistance with design of the new facility and training of staff. Uzbekistan KyrgyZstan

Singapore In the fall of 2012, the Asian Centre for Liver Diseases & Malaysia Transplantation (ACLDT) in Singapore, one of Asia’s foremost liver centers, joined with UPMC to develop a Comprehensive Malaysia Transplant Centre (CTC) to treat liver, kidney, and bone marrow Singapore diseases. The CTC will specialize in transplant immunology, transplant, infectious diseases, and intensive care of Indonesia immunosuppressed patients. The two organizations will Indonesia collaborate in the planning and design of the CTC, which will serve as a regional hub, extending services to other countries in southeast Asia.

University of Pittsburgh Cancer Institute | 9 10 | UPMC CancerCenter Living a Legacy; Advancing a Cause A cancer diagnosis can affect a person in many different ways. Some people may look to the past to rekindle old friendships, others may take the opportunity to live in the moment, and some may look for ways to create hope for patients in the future.

Since 2007, Ray Lamont, a retired medical researcher from Ray and Sarah’s gift will support future research in the Albuquerque, N.M., has faced and beaten cancer six times. His personalization of head and neck cancer therapies. Dr. Bauman latest diagnosis of an inoperable head and neck cancer metastasis and the research team are laying the groundwork for this type at the base of his neck came in January 2013. Since his initial of research at UPCI, which involves identifying informative methods diagnosis, Ray has endured grueling treatments that have included with the ability to match tumor characteristics, such as mutations maximum doses of radiation administered simultaneously with in a certain patient, to a specific anti-cancer drug. Currently, aggressive chemotherapy drugs and multiple surgeries, including Dr. Bauman and colleagues are developing clinical trial platforms a surgery to remove his sciatic nerve, the longest nerve in the body, to translate lab findings into clinical application. which was engulfed in tumors. “Ray is a keenly scientific and deeply spiritual man,” said “Despite my obstacles, I feel truly blessed,” said Ray. “I have Dr. Bauman, director of the Head and Neck Cancer Section and been able to take advantage of and appreciate some of the best Thyroid Cancer Section in the Division of Hematology-Oncology, medical expertise and technology available.” With a “pay it forward” and co-director of the UPMC Head and Neck Cancer Center of mentality, Ray, along with his wife of 44 years, Sarah, established Excellence. “We hit it off from the beginning for both of those a planned gift to benefit the University of Pittsburgh Cancer Institute reasons. Every aspect of his journey has been about identifying (UPCI) in honor of Ray’s medical oncologist, Julie Bauman, MD, the meaning of his experience to enrich the lives of others.” MPH, who was recruited to UPCI in September 2012. Since being diagnosed, Ray has established a head and neck cancer A planned gift is the promise of future support to a charity and support group, and Sarah facilitates a cancer caregiver support group. enables the donor to create a meaningful and permanent connection to a cause that is important to them. Planned gifts can be established “We believe that those with a positive attitude seem to experience as gifts by will or living trust, in the form of retirement plan benefits, less pain and recover more rapidly,” said Ray. “I don’t know if that’s or with a life insurance policy. They provide a way for donors to true, but we believe that’s a major factor in recovery from this type continue their legacy, offering the opportunity for their gift — and of disease. We hope to encourage others to defy the challenges connection to the mission — to continue long after they’re gone. presented to them.” In addition to feeling connected to the cause, donors often consider Ray and Sarah’s bequest represents a timeless way to forever a planned gift to motivate and encourage others. align themselves with improving care for head and neck cancer “The goal of our planned gift is to let people know that there are a lot patients in the future. of great research opportunities available for head and neck cancers,” “We just think the world of Dr. Bauman and what she does,” said Ray. “The advances in head and neck cancer treatment in the said Ray. “That’s why we set up this planned gift to honor last five to 10 years have been marvelous, and UPCI and Dr. Bauman the great cancer research and clinical care at UPCI and are at the forefront of these discoveries. We want to continue to UPMC CancerCenter.” encourage additional research.”

University of Pittsburgh Cancer Institute | 11 Living a legacy; Advancing a cause Providing a Good Night’s Rest Cancer Sleep Clinic available at Hillman A Levin legacy Levin Furniture originally opened its doors in 1920 and sold hardware items as well as furniture. Since then, the store in rural Research suggests cancer patients are three Mount Pleasant, Pa., has evolved into 23 furniture and mattress locations throughout western Pennsylvania and eastern Ohio. times more likely to have trouble sleeping, Since its humble beginnings, Levin Furniture has remained a true and some sleep problems can last even after family business, growing as each new generation took the helm. treatments have ended. This lack of sleep Sally Levin, the matriarch of the Levin family, Sally Levin came on board with her husband, Leonard, can cause depression, anxiety, irritability, as buyer, merchandiser, advertiser, decorator, and poor concentration, and can impact a and design consultant. Sally was inspired to join the UPCI Council as one of its original patient’s pain sensitivity and overall health. members following her own lymphoma Led by Amy Lowery, PhD, sleep specialist and clinical psychologist, diagnosis and the death of her husband from and Behavioral Medicine Clinical Services Program, was complications of lung cancer. Since becoming initiated in 2012. The clinic was designed to address sleep a council member, Sally has had two more problems in cancer patients by using behavioral treatments, personal bouts with cancer. which may be more effective and cause fewer side effects with In 2012, Sally’s children established the Sally M. Levin Endowed Fund longer-lasting benefits than taking medication alone. for Innovative Cancer Research to celebrate her accomplishments, “Sleep disturbances are increasingly recognized as a significant both as a businesswoman and a cancer survivor. Created as a major side effect of cancer treatment and can affect an individual legacy gift, the funds will provide seed money for research led by physically and psychologically,” said Dr. Lowery. “Sleep investigators with original ideas. problems vary greatly from patient to patient. With a careful The fund will be especially helpful to young investigators, evaluation of the factors affecting a person’s sleep, we can as research is costly, and there is a pressing need for funding that develop a plan to help the patient get a good night’s sleep.” encourages innovative research. The idea is that the preliminary Ellen Ormond, PhD, associate director, Behavioral Medicine studies supported by the Levin Fund will help investigators to Clinical Service Program, feels the new service is an important secure additional funding, such as federal grants. expansion of the program’s psychological services. “We feel, as citizens of the city of Pittsburgh, a special commitment “I’ve felt for many years that taking care of people’s sleep is to strengthening institutions that have a special role in the city. one of the most important ways to improve the quality of both And certainly UPCI is a jewel, and one that needs to be supported their physical and emotional life,” said Dr. Ormond. “It is by the community,” notes Sally’s son Robert. “We’re really thrilled miserable to be awake during the night, and sleep deprivation to be doing that.” depletes our resources for dealing with the challenges of life Leaving a legacy and for enjoying our day.” Legacy and planned gifts play an important role in strengthening Common problems for which a cancer patient may seek out research and clinical programs and services at UPCI and UPMC the Cancer Sleep Clinic include: CancerCenter. As long as cancer continues to be a major health care concern in this community and beyond, there will be a need •• Trouble falling asleep for support to ensure that UPCI and UPMC CancerCenter remain •• Waking up in the middle of the night or very early world-class institutions. For more information about planned in the morning giving opportunities at UPCI and UPMC CancerCenter, •• Feeling tired during the day call 412-623-4700. Although sleep problems often begin during treatment, they can develop into a disorder of their own. The Cancer Sleep Clinic offers the benefit of receiving treatment from a cancer and sleep specialist who understands the patient’s unique needs.

12 | UPMC CancerCenter Amy Lowery, PhD

Treatment at the clinic is designed to be brief and is available for patients, family members, and caregivers. The first visit involves a detailed interview to learn more about the patient’s sleep behaviors, daily routines, diet, medications, and stressors. Some patients may be asked to monitor their sleep activity by keeping a sleep log at home or wearing a special watch that According to Dr. Ormond, the main benefits of having a behavioral detects movement. An individualized treatment plan is then medicine program at a cancer center are convenience and the created for each patient, tailored to address his or her specific specialized expertise. Each psychologist in the program is trained problem, and may include different behavioral and cognitive to work with patients, family members, and caregivers who have techniques. Dr. Lowery also teaches patients about sleep and been touched by cancer. how it can be affected by different things they do. “There are many medical factors that can affect our quality of “On average, I see patients for approximately six sessions,” life,” said Dr. Ormond. “For example, some medications can said Dr. Lowery. “Some patients only need two to three sessions, increase anxiety or disrupt sleep. When a patient comes to us for while others continue to see sleep improvement with 10 to 12 anxiety, we can look at their prescribed medications to determine sessions. Most importantly, patients come away with a greater if something they are taking may be the cause of their increased understanding of how their sleep can be impacted and the tools anxiety. We are knowledgeable about the interactions of medicine they can use if it ever becomes a problem again in the future.” and psychological factors and can work with the patient’s oncologist to best manage all of the patient’s symptoms.” Depending on the nature of the sleep problems, other specialists in the program may become involved in the treatment plan. In Program’s success marked with creation of new section addition, patients with signs of movement or breathing-related The success of the Behavioral Medicine Clinical Service sleep disorders may be referred to a sleep physician. Program has resulted in an expansion, creating the Section of Psycho-Oncology within the Division of Hematology-Oncology. Building on the clinic’s success, Dr. Lowery is working to expand The new section is headed by psychiatrist Kevin Patterson, MD, the service by presenting and offering services at local cancer who currently works with cancer patients and those with other community organizations, such as Gilda’s Club and Cancer medical illnesses. Caring Center. In his new role as clinical director and director of the Section UPCI’s Behavioral Medicine Clinical Service Program of Psycho-Oncology, Dr. Patterson continues to work with The Behavioral Medicine Clinical Service Program is a team of Dr. Ormond in expanding the psycho-oncology services offered psychologists and psychiatrists who help cancer patients and their to cancer patients and their families. In addition, he and Dana families deal with emotional issues, such as worry and anxiety, Bovbjerg, PhD, leader of the Biobehavioral Medicine in Oncology sadness and depression, explaining a cancer diagnosis to children, Program of UPCI, along with other research scientists, will work stress management, survivorship and post-treatment issues, to develop novel clinical and translational research initiatives. and more. When Dr. Ormond began at UPCI in 1988, having a behavioral medicine program embedded into a cancer center was The Behavioral Medicine Clinical Service Program will be merged rare. But since she was recruited, the program has grown and has into this new section. The growth of the program, including the become an important part of treatment for cancer patients, thanks success of the Cancer Sleep Clinic, is a shining example of the to UPMC’s strong commitment to the patient’s quality of life. program’s continued benefit to cancer patients and their families.

“The stigma about mental health in the late 1980s was larger,” said Dr. Ormond. “At the time, people didn’t talk about mental For more information about the Cancer Sleep Clinic or health, and it was always about medicine. If you look now, you the Behavioral Medicine Clinical Service Program, visit see the importance of talking about the impact of cancer on our UPMCCancerCenter.com/behavmed or call 412-623-5888. lives and relationships.”

University of Pittsburgh Cancer Institute | 13 Scott A. Garet

14 | UPMC CancerCenter Lung Cancer: Speaking Up for a Misunderstood Disease At age 26, Scott A. Garet, of Washington, Pa., was what many would call healthy. A former high school and collegiate athlete turned competitive distance runner, Scott carried his love for athletics into adulthood.

He graduated in 2007 with a degree in mathematics from Armed with the drive to inform the community and help others Waynesburg University, a small Christian university one hour battling the disease, Scott’s family developed the Scott A. Garet south of Pittsburgh. He spent his professional time molding the Memorial Foundation, which strives to build awareness and raise minds of students in western Pennsylvania as a substitute teacher, funds on behalf of lung cancer research at the University of Pittsburgh most regularly at Washington High School in Washington, Pa. Cancer Institute (UPCI). “We want people to understand that lung In his free time, he provided private tutoring and standardized cancer is a disease that can affect anyone. We hope that supporting test preparation and gathered with friends to train for short- research efforts will help to find more effective treatment options for and long-distance running events. those currently battling this disease, as well as those who will battle it in the future,” said Michael Garet, Scott’s older brother. In September 2011, Scott was diagnosed with a Stage IV mixed-cell carcinoma lung cancer. That December, despite the best efforts of The foundation’s largest fundraiser, the Flying Monkey 5K, his oncologists, he lost his battle with cancer. wholeheartedly reflects Scott’s spirit and love of running. Since its first race in summer 2012, the event has raised more than $25,000 Never a smoker and always health conscious, Scott and his for lung cancer research at UPCI. family were baffled by his diagnosis and its severity. They always thought of lung cancer as a smoker’s disease. Upon his passing, Continuing a legacy: a family’s message his family and friends were moved by the outpouring of support, Dr. and Mrs. Jack Hill understand the loss the Garet family but troubled by the naiveté of the general public regarding the experienced in 2011. The Hills’ daughter, Suzanne Hill Alfano, 38, causes of lung cancer. passed away in 2001, just 13 months after her lung cancer diagnosis. Dr. Hill, a retired cancer specialist, knew the complexities of lung According to Mark A. Socinski, MD, director of the Lung Cancer cancer and the often inaccurate stereotypes associated with the Section of the Division of Hematology-Oncology at UPMC disease. “We know that smoking can cause lung cancer, but not CancerCenter and co-director of the UPMC Lung Cancer Center everyone who gets lung cancer is a smoker,” said Dr. Hill. “Suzanne of Excellence, people are often surprised to learn that while smoking never smoked, and without available, regular screening methods, is the leading cause of lung cancer, fewer than 10 percent of smokers it was too late to cure her cancer or determine what might have are diagnosed with the disease. “Most of the public assumes that been the cause. People don’t have the facts about lung lung cancer is a smoker’s disease but most smokers do not develop cancer, and genetics research is still in its early stages.” lung cancer, and approximately 25,000 U.S. citizens who are never smokers will develop lung cancer this year,” said Dr. Socinski.

University of Pittsburgh Cancer Institute | 15 Lung Cancer: Speaking Up for a Misunderstood Disease

To make the public more aware of what a global health concern treatments will be, and the more likely we will be able to develop lung cancer is, the Hills created the Suzanne Hill Alfano Endowment alternative, targeted therapies,” said Dr. Socinski. for Lung Cancer Research to benefit lung cancer research at UPCI. The goal of this endowment is to support the lung cancer program’s These types of advances are taking place in the lab formerly led by efforts to better understand the causes of lung cancer and to develop Jill M. Siegfried, PhD, former co-director of the Lung and Thoracic a reliable screening method and more effective treatment. Malignancies Program at UPCI. “Once it became clear that there were genetic mutations causing lung cancer, it seemed natural to Dr. and Mrs. Hill have spent countless hours advocating for awareness investigate those mutations against the previously known cancer- that lung cancer is the number one cause of cancer death in both causing genetic mutations of other cancers, such as breast cancer,” men and women and that it is not just a disease of active smokers. said Dr. Siegfried, who recently moved to become the Chief of pharmacology at the University of Minnesota. “It’s frustrating that most aren’t diagnosed until the cancer is in its advanced stages,” said Mrs. Hill. “If earlier screening methods, Dr. Siegfried and her team built upon the knowledge that estrogen improved testing, and more advanced treatments were available, receptors are found in the lungs and in lung tumors, similar to those lives like our daughter’s may be saved,” she said. “Although CT scans found in the mammary glands of breast tissue. She and her team can reveal lung cancer before other tests, a yearly CT scan for began by targeting lung cancers found to be estrogen receptor everyone is not financially practical. Our goal is to advance lung (ER)-positive, just as certain breast cancers are ER-positive. “We cancer research to a point where annual exams can help to protect know that estrogen is produced locally in lung tissue, and that patients and their families from finding out too far down the line.” inflammation, often caused by smoking, may cause the overproduction of estrogen,” said Dr. Siegfried. “With this knowledge, we were able Lung cancer behind the scenes: in the lab and on the ground to identify a relationship between the overproduction of estrogen in According to Dr. Socinski, in addition to the stigma surrounding the the lung tissue and cancer, similar to the link between overproduction disease, a focus on lung cancer is relatively new to the field of cancer of estrogen and cancer in the mammary glands.” research. “Lung cancer was not investigated and approached by oncologists as a treatable cancer until 1995, when a landmark paper This discovery led to Dr. Siegfried’s team using anti-estrogen showed that chemotherapy proved to be beneficial to lung cancer treatments, and because these estrogen receptors are expressed patients,” said Dr. Socinski. “That’s only 18 years of research, clinical equally in men and women, it shines a new light on both causes trials, data collection, and attempting to understand the underlying and potential treatments for lung cancer. biology of this very heterogeneous disease.” Currently, the team is participating in a Phase II clinical trial that Although Dr. Socinski did not treat Suzanne or Scott, he said combines the treatment, Erlotinib, an oral drug that targets the funds being raised by their friends and families will make an epidermal growth factor receptor (EGFR), with anti-estrogens. impact for years to come at a better time in lung cancer research. “Hopefully, this advances to a larger, Phase III trial,” said Dr. Siegfried. Dr. Socinski and his colleagues at the UPMC Lung Cancer Center of “That would give us more data to pull from, significantly changing Excellence don’t want the history of lung cancer to be overshadowed our understanding of biological pathways that contribute to lung by the impressive progress completed in this short time. cancer, and how ER-related biomarkers can be used as a potential personalized treatment plan.” According to Dr. Socinski, the significance of understanding genetic mutations, such as the epidermal growth factor receptor (EGFR) Similar to other cancers with decades more research, trials, and mutation, a mutation known to cause cancer cells to rapidly divide, data, both genetic and hormone research for lung cancer can be the is paramount to the success of lung cancer research and treatment keys to research progress and treatment methodology, as well as the development. This knowledge feeds the widely adopted personalized ability to more accurately screen for lung cancer at earlier stages, medicine approach to lung cancer treatment, which at UPMC and potentially use cancer-associated biomarkers to detect tumors CancerCenter begins with the use of a standard eight-panel test of before they progress and spread. various genetic markers that can impact the type of treatment selected for each individual. Taking the team approach for a chance at victory As is the case for many cancers, it is often a combination of Dr. Socinski sees this as the future of lung cancer treatment. treatments that form the personalized approach to effectively battle “The more we understand these genetic markers and potential a lung cancer diagnosis. cancer-causing mutations, the more effective our existing

16 | UPMC CancerCenter According to Arjun Pennathur, MD, surgical oncologist, Department Excellence (SPORE), where we are currently studying tumor tissues of Cardiothoracic Surgery, a lobe resection, or complete removal of for biomarkers that could identify potential gene expression data. one lobe of the lung, is often the preferred method of treatment for This would give us knowledge of how certain tumors might behave most Stage I and II lung cancers. However, due to the advanced and, therefore, insight to develop the best treatment plans.” age of most lung cancer patients, such an extensive surgery is often too risky for the patient. Dr. Pennathur also is collaborating with Dr. Socinski on a clinical trial, investigating the use of vaccines in lung cancer treatment and To overcome this hurdle, Dr. Pennathur teamed up with his medical follow up care. The trial, still in its early stages, involves studying the and radiation oncology colleagues to develop treatment plans that genetic makeup of lung cancers. Based on the findings, a vaccine is include sublobectomies, a less-invasive option that involves only used to kill the cancerous cells while developing antibodies against a partial resection of the lobe, either before or after chemotherapy that specific type of cancer. These vaccine therapies are becoming or radiation treatments. These multidisciplinary treatment and more widely studied as neoadjuvant (before surgery or radiation) research relationships have opened the door to personalized and adjuvant (after surgery) therapies. treatment plans and surgical techniques. With research always in progress, lung cancer treatment “UPCI really is at the forefront of innovative therapies for lung continues to improve and chip away at the staggering statistics cancer patients,” said Dr. Pennathur. “I work closely with the that keep this cancer ranked as the number one cancer killer investigators in the Lung Cancer Specialized Programs of Research of Americans.

“The more we understand these genetic markers and potential cancer-causing mutations, the more effective our existing treatments will be.”

Mark A. Socinski, MD, Arjun Pennathur, MD, and Jill M. Siegfried, PhD

University of Pittsburgh Cancer Institute | 17 Women’s Cancer Update

Putting the “Fun” in Fundraising

It is estimated that during 2013, hundreds of thousands of women were diagnosed with breast, ovarian, cervical, or endometrial cancer. With such a large impact, women’s cancers receive the attention of many charitable organizations built by the affected women, families, and friends. Here are some creative fundraising initiatives that benefit women cancer patients and research at UPMC CancerCenter and the University of Pittsburgh Cancer Institute (UPCI).

Hackers for Hope Pittsburgh hosted their annual golfing event on The Patient Assistance Fund was established in 2005 to help May 17, at the Longue View Club in Verona, Pa. At this event, 16 local cancer patients across the UPMC CancerCenter network overcome “hackers,” sponsored by families, friends, and companies, played golf some of the financial barriers associated with completing treatment. from 7 a.m. to 7 p.m., followed by evening activities that included Since its inception, the fund has helped more than 3,400 patients dinner, dancing, and a silent auction. at 32 different UPMC CancerCenter sites throughout western Pennsylvania. To learn more about how to support the Patient On July 30, Green Oaks Country Club hosted Tee Up for the Cure, Assistance Fund, contact the development office at 412-623-4700. another golf event that raises money for women’s cancer research at Women’s Cancer Research Center. Before tee off, Dr. Carola The Fashion Footwear Charitable Foundation supports research Neumann and Dr. Priscilla McAuliffe updated attendees on and education programs in the fight against breast cancer and is UPCI news, and survivors were acknowledged. backed by members of the Fashion Footwear Association of New York Inc. (FFANY). During the QVC and Fashion Footwear Charitable In October, the Breast Cancer Research Foundation recognized Foundation’s annual charity benefit QVC Presents “FFANY Shoes on their commitment to provide UPCI with four grants totaling nearly Sale,” new footwear donated by designers is sold live on television to $1 million in breast cancer research support. These grants extend benefit breast cancer research. This year’s benefit was held on Oct. 1. to Sept. 30, 2014, and specifically fund the research efforts of Last year, FFANY and QVC donated $200,000 to UPCI as a leading principal investigators Nancy E. Davidson, MD, director, UPCI and breast cancer research institution in the United States. UPMC CancerCenter; Adrian Lee, PhD, director, Women’s Cancer Research Center, UPCI; and Steffi Oesterreich, PhD. In addition to All of these fundraising initiatives are made possible by motivated these grants, UPCI continues to be the U.S. headquarters for the individuals who form a community of support and encouragement North American Breast Cancer Group/Breast International Group around women with cancer. Whether they are survivors, family, collaboration through foundation funding. friends, or others with a passion for giving to those affected by the disease, these groups are an integral part of the fight The Pink Pamper hosted its 6th annual Health and Beauty against cancer. Fair for Charity in Pittsburgh on Nov. 3. The Health and Beauty Fair featured product vendors, auction drawings, and beauty professionals who volunteered their time to provide haircuts, To learn more about fundraising initiatives that benefit UPCI and UPMC manicures, massages, and many other services for a fraction of CancerCenter, visit the Event section of UPMCCancerCenter.com or their normal price. The event raised funds to benefit several like us on Facebook.com/UPMCCancerCenter. For more information charities that directly benefit oncology patients, including the about supporting these and other events, contact the development UPMC CancerCenter Patient Assistance Fund. office at 412-623-4700.

18 | UPMC CancerCenter Women’s Cancer Update

Breast Cancer: At the Forefront of Personalized Medicine

More than 230,000 women will be diagnosed with breast cancer in the United States this year, a diagnosis that comes with treatment choices that can be overwhelming. But what if there was a best treatment for your breast cancer? And what if it was based on your genetics and specific cancer type in the hope of maximizing its effectiveness?

That’s the promise of personalized medicine and research the “For the first time, by electronically integrating clinical and genomic University of Pittsburgh Cancer Institute (UPCI) is bringing closer information on those patients previously treated for breast cancer, to reality every day. Just eight months after UPMC announced Pitt researchers found molecular differences in the make-up of a $100 million, five-year project to create a unique warehouse pre-menopausal vs. post-menopausal breast cancer. While of clinical and other data, UPCI researchers said they had understanding those differences will require more research, found differences among some breast cancer patients, which the findings eventually could provide a roadmap for developing eventually could provide a roadmap for developing these targeted, targeted therapies,” notes Dr. Lee. personalized therapies. “Women with pre-menopausal breast cancer tend to have worse “Cancer is driving much of personalized medicine. Not only is outcomes, but we tend to treat them the same as post-menopausal cancer on pace to soon surpass heart disease as the number breast cancer patients. Understanding the genetic differences one killer of Americans, but it’s an area where we give the same between these cancers will likely lead to findings for unique therapy to almost everyone — whether it works for them or not. therapies in those patients,” said Dr. Lee. With personalized medicine, we can do better,” said Adrian V. Lee, PhD, a renowned expert in the molecular and cellular biology of UPMC has partnered with Oracle, IBM, Informatica, and dbMotion. breast cancer and director of the Women’s Cancer Research Its advanced analytic and predictive modeling applications for clinical Center at UPCI and Magee-Womens Research Institute. and financial decision-making are expected to produce better patient outcomes, enhanced research capabilities, continual quality UPMC launched its enterprise analytics effort with its research improvements, and reduced costs. partners at the University of Pittsburgh last October with the goal of mining massive amounts of data — clinical, genomic, proteomic, “Having this kind of detailed data allows us to ask questions we never imaging, and financial, to name a few — in the pursuit of smarter asked before. And obviously, it will continue to grow. The more patients medicine. Traditionally, these data have resided in separate involved, the more we can learn from it,” said Dr. Lee. According to information systems, making it difficult, if not impossible, Dr. Lee, researchers hope to add data from ovarian and head and neck to integrate and analyze dozens of variables. cancer patients to the information warehouse starting next year.

UPMC chose breast cancer research as its first test of this Other new technologies are already bringing personalized medicine “big data” effort because researchers at UPCI had rich genomics into clinical practice. In a newly expanded Clinical Laboratory data available on 140 patients. Their de-identified information Improvement Amendment (CLIA)-validated laboratory at the previously had been obtained as part of a federally funded project University of Pittsburgh, pathologists are sequencing cancer called The Cancer Genome Atlas (TCGA), a multi-center effort genomes for patients suffering from late-stage lung, colon, breast, to produce comprehensive genomic maps of the most common and other cancers. The team, under the direction of Yuri Nikiforov, cancers. The University of Pittsburgh was the largest contributor MD, vice chair of Pitt’s Department of Pathology, has already done of tissue to TCGA. 100 tests using the new technology and hopes one day to be able to offer such testing to patients at any stage. “We have so much data available to us and believe we can work to make diagnosis and treatment more precise and efficient,” said Nancy E. Davidson, MD, director of UPCI and UPMC “There is no question, this is CancerCenter and a breast cancer researcher. the future of medicine.” YURI NIKIFOROV, MD

University of Pittsburgh Cancer Institute | 19 Ronald B. Herberman, MD

20 | UPMC CancerCenter Remembering Ronald B. Herberman, MD Ronald B. Herberman, MD, dedicated his entire career to advancing cancer research and care by working diligently to identify new discoveries. His renowned studies played a major role in developing novel approaches to cancer therapy, which we at UPCI, and the cancer community as a whole, continue to leverage today.

And it was through his devotion and vision that Dr. Herberman The beginning of a world-class institution helped to shape the University of Pittsburgh Cancer Institute In 1985, Dr. Herberman was recruited to establish a cancer (UPCI) into one of the nation’s leading National Cancer research center in Pittsburgh. With funds generously provided Institute (NCI)-designated Comprehensive Cancer Centers. by the Richard King Mellon Foundation, Dr. Herberman wasted no time in creating his vision. He recruited promising researchers Sadly, our long-standing colleague and friend, Dr. Herberman, to start experimental research and founded the UPCI advisory founding director of UPCI, passed away suddenly in May 2013, council, comprised of Pittsburgh’s prominent leaders, to provide at age 72. advice and support. The center quickly became one of the “Ron’s vision, energy, and tenacity were unparalleled. He truly fastest-growing cancer institutes in the country. laid the foundation for UPCI and UPMC CancerCenter to emerge Within three years, Dr. Herberman had secured funding as a world-class cancer center,” said Nancy E. Davidson, MD, and designation from the NCI for UPCI as a Clinical Cancer director of UPCI and UPMC CancerCenter. “He was a strong Research Center. And by 1990 — only five years after believer in the power of great science to make a difference in establishing the institute — UPCI received the prestigious the complex set of diseases that we call cancer.” NCI designation of Comprehensive Cancer Center, a designation maintained under Dr. Herberman’s leadership. Roots in immunology Before coming to Pittsburgh to lead efforts to build what is now “Ron was unrelenting and single-minded in his commitment known as UPCI, Dr. Herberman, an internationally recognized to UPCI, from our first meetings to discuss this new cancer tumor immunologist, spent 19 years at the National Cancer institute in 1985, to our launch of proposals for Biological Institute’s (NCI) Immunology branch, where his discoveries Response Modifiers Program funding in 1986 and our first core increased the cancer community’s understanding of tumor grant submission only a few years into existence,” said John development and progression, and led to novel approaches for Kirkwood, MD, Usher Professor of Medicine, Dermatology and preventing the spread of cancer. Translational Science and co-leader of the Melanoma and Skin Cancer Program at UPCI. “He served as a role model for selfless “Dr. Herberman was a visionary leader who worked tirelessly, commitment to UPCI for all of our founding members, and all marshaling every resource in the fight against cancer,” said of its members today.” Maryann Donovan, PhD, MPH, associate director of research administration at UPCI. “He was devoted to identifying cancer risk factors and prevention strategies, improving early detection, developing more innovative treatments, and enhancing options for cancer survivors.”

University of Pittsburgh Cancer Institute | 21 Remembering Ronald B. Herberman

“When I walk into Hillman Cancer Center now as a patient, I can smile and say that I knew and worked with the man who was behind creating this great institute. I am very encouraged, knowing that the research and treatment coming out of this facility is a result of Dr. Herberman’s vision.”

Dr. Herberman also served the greater University of Pittsburgh community in many ways, including as associate vice chancellor for cancer research, Hillman professor of oncology, professor of medicine and pathology at the University of Pittsburgh School of Medicine, and chief of the Division of Hematology-Oncology in the Department of Medicine. He also was devoted to the community as a whole, serving on the board of directors of Central Blood Bank of Pittsburgh, Family House, and the American Cancer Society, East Central Division.

After more than two decades, Dr. Herberman retired in 2009, so he could dedicate more time to his research interests, and was succeeded by Dr. Davidson. He then joined Intrexon Corporation in Germantown, Md., as chief medical officer for oncology, and remained there until 2012. At the time of his death, Dr. Herberman was serving as senior vice president Continued growth and advances and chief medical officer at TNI BioTech, Inc. Dr. Herberman oversaw the expansion of UPMC’s clinical oncology services into a growing number of network sites “He was a success in all he did, serving as an international throughout western Pennsylvania and eastern Ohio — now expert in cancer immunology at the NCI, then as founding known as UPMC CancerCenter. He spearheaded the opening of director of UPCI, and finally as chief medical officer for two Hillman Cancer Center in 2002, a physical representation of the different biotech companies. Few people can do so much vision he had for UPCI in its earliest years: an environment with across such diverse positions,” said Dr. Davidson. the latest technologies for scientific investigation, linked by physical and intellectual bridges to a hospital and outpatient The University of Pittsburgh, UPCI, and UPMC CancerCenter treatment facility, where research could be applied in a clinical extend our deepest condolences to Dr. Herberman’s family. setting by some of the world’s brightest researchers. The Ronald B. Herberman, MD Lectureship Fund will be “Without his vision and drive, UPCI would not exist as we established in Dr. Herberman’s memory and will be awarded know it today,” said Dorothy Mann, executive assistant to at the annual UPCI Scientific Retreat. Contributions to Dr. Davidson, former executive assistant to Dr. Herberman, this fund may be made by calling the development office and one of UPCI’s first employees, as hired by Dr. Herberman. at 412-623-4700.

A Lasting Reminder

In recognition of his many contributions in providing service to the research The following individuals have received this to UPCI and UPMC CancerCenter, the community. It is presented during the prestigious award: Ronald B. Herberman, MD, Research annual UPCI and UPMC CancerCenter Jeffrey Germuska, 2012 Chrissie Usher, 2010 Staff Appreciation Award was established Oncology Award ceremony, celebrated in in 2009. The award honors dedicated the Ronald B. Herberman Conference Thomas Williams, 2012 Nicole Webb, 2009 UPCI research and staff members for Center, housed on the second floor of the Megan Seippel, 2011 outstanding performance and excellence UPMC Cancer Pavilion in UPMC Shadyside.

22 | UPMC CancerCenter Community Events Prove to be Strong Assets

One way in which UPCI and UPMC CancerCenter benefit from the generosity of its donors is through the many community events held throughout western Pennsylvania to support our cancer research and clinical care provided here.

UPCI and UPMC CancerCenter gratefully acknowledge the following events* and their organizers, volunteers, and participants who worked so tirelessly to contribute to our mission.

Calla Lily Cup Golf Outing Fashions for a Cure Fashion Show Race Against Cancer 5K Benefiting multiple myeloma research Benefiting UPMC CancerCenter Benefiting UPMC CancerCenter July 2012 Patient Assistance Fund Patient Assistance Fund October 2012 May 2013 Pittsburgh Cure Sarcoma 5K Benefiting sarcoma research Shoot for A Cure Target Shoot Walk to End Brain Cancer 5K July 2012 Benefiting breast cancer research Benefiting brain cancer research October 2012 May 2013 Stampede in the Park 5K Benefiting leukemia research CMU Memorial Football Game Hackers for Hope Golf Outing July 2012 Cynthia Lackner Benefiting UPMC CancerCenter Benefiting breast cancer research Cancer Family Registry Tee Up for the Cure Golf Outing October 2012 May 2013 Benefiting breast cancer research July 2012 Pink Pamper Annual Health and Miles Against Melanoma Golf Outing Beauty Fair Benefiting melanoma research and Flying Monkey 5K Benefiting UPMC CancerCenter clinical programs Benefiting lung cancer research Patient Assistance Fund May 2013 August 2012 November 2012 S.T.O.M.P (Saulle’s Teddy Bear Official Curtis Patterson 5K Pennsylvania Interscholastic Hockey Memorial Parade) Benefiting colon cancer research and League (PIHL) Outdoor Charity Series Benefiting the Linda Saulle Endowed UPMC CancerCenter Patient Assistance Fund Benefiting innovative cancer research Memorial Fund for colon cancer research August 2012 February 2013 May 2013

Friends of Kathy Vetere Golf Outing Miles Against Melanoma Wining Against Cancer Fashion Show Benefiting breast cancer research Retro Trivia Night Benefiting brain cancer research August 2012 Benefiting melanoma research and May 2013 clinical programs Moniteau School District March 2013 Spend A Day at the Keys Golf Outing Senior Project Softball Tournament Benefiting head and neck cancer research Benefiting breast cancer research Cookies4Chris June 2013 September 2012 Benefiting colon cancer research April 2013 Miles Against Melanoma 5K The Grey Ribbon Affair Benefiting melanoma research and Wine, Cheese and Chocolate Tasting Hoops for a Cure “All Star” clinical programs Benefiting brain cancer research Basketball Games June 2013 October 2012 Benefiting the Nathan S. Arenson Fund for Pancreatic Cancer Research April 2013 *Events listed occurred from July 2012 through June 2013.

University of Pittsburgh Cancer Institute | 23 CancerCenter. Growing from seven founding members in 2002 to 143 members in 2013, the Circle of Hope represents many millions of dollars in philanthropic gifts over an 11-year period.

As broadly as Circle of Hope membership spans in terms of geography — with 34 percent of all members living outside of Allegheny County — its collective return on investment is even more expansive. Cumulatively, annual At UPMC CancerCenter, partner with University renewals of support from these major donors have made of Pittsburgh Cancer Institute (UPCI), every a highly significant impact on progress in a broad philanthropic contribution — whether made as a spectrum of cancer research and patient care programs, donation, sponsorship, community-based event, making it possible for our scientific and clinical experts planned gift, in-kind support, or volunteerism — to pioneer advances that lead to improvements in cancer helps us in our efforts to improve the lives of all prevention, detection, and treatments. cancer patients and survivors.

The Circle of Hope is a special recognition society With tremendous gratitude, we thank all donors to that honors individuals, family foundations, UPCI and UPMC CancerCenter and extend a special and privately held companies who have committed salute to all Circle of Hope members for such a minimum of $10,000 during a calendar year extraordinary philanthropic leadership and, above all, to support programs at UPCI and UPMC for sharing our commitment to a future without cancer.

Faces of Hope: A Future Without Cancer On Sept. 14, 2012, more than 800 of the region’s most the presenting sponsor. Chris Mann, finalist on the NBC influential community leaders and supporters gathered hit television series “The Voice,” and renowned trumpeter at Center for the 2012 Hillman Cancer Benny Benack provided the evening’s entertainment. Center Gala, Faces of Hope: A Future Without Cancer, Faces of Hope: A Future Without Cancer highlighted the to recognize millions of dollars raised for innovative importance of supporting personalized medicine research cancer research and treatment, and to celebrate the that focuses on the development of treatments for all types advanced cancer research and patient care programs at and stages of cancer. The emphasis is on personalizing Hillman Cancer Center and in the UPMC CancerCenter cancer care to ensure each patient receives the prevention, network. Dr. Mark Socinski was honored as the 2012 detection, and treatment strategies most appropriate for PNC/UPCI Director’s Distinguished Scholar. him or her. Gala leadership and supporters included honorary Look for a recap of the 2013 gala, Living Courageously: co-chairs Elsie and Henry Hillman, and Cathy and A Future Without Cancer, in the 2014 edition of Cancer Sy Holzer. Event co-chairs were Becky and John Discovery & Care. Surma, and Christina and Carlos Cardoso. PNC was

24 | UPMC CancerCenter ENDOWED CHAIRS The Mario Lemieux Foundation David C. Koch Memorial Fund A number of endowed chairs support the The Leukemia and Lymphoma Society The Kramer-Neiderhiser Endowed Fund mission of University of Pittsburgh Cancer McCune Foundation in Blood Cancers Research Institute, partner with UPMC CancerCenter. James S. McDonnell Foundation The Kramer-Neiderhiser Endowed Fund The income generated from endowed chairs in Ovarian Cancer Research Richard King Mellon Foundation enables our scientists, clinicians, and their Mario Lemieux Patient Care and Cancer Metanexus Institute teams to strengthen established areas of Research Fund expertise, expand new initiatives, and forge N.S.A.B. P. Foundation, Inc. Sally M. Levin Endowed Fund for new frontiers in science that benefit our patients Arnold D. Palmer 2003 Charitable Trust Innovative Cancer Research and their families now and into the future. CIRCLE OF HOPE The Pittsburgh Foundation Scott Limbach Entrepreneurial Center The Claude Worthington Benedum PNC Financial Services Group and Robert J. Mann Memorial Fund The Circle of Hope honors individuals, family Endowed Chair in Radiation Oncology PNC Foundation foundations, and privately held companies Stanley M. Marks, MD, Endowed The Jane and Carl Citron Endowed Chair Myles D. Sampson* and Family that make contributions of $10,000 or more Research Fund in a calendar year. This list recognizes those in Colon Cancer Sanofi-Aventis The Liliana Muhlmann Masoner who were members in 2012 and 2013, as of The Richard M. Cyert Endowed Chair The David S. and Karen S. Shapira Cancer Fund August 30, 2013. in Molecular Oncology Foundation Drew Mathieson Entrepreneurship Fund The Gregory T.H. Davies Endowed Cheryl and Bruce Americus Sandra and Thomas Usher James A. Mollica Jr. Research Chair in Brain Tumor Research and The V Foundation for Cancer Research Endowment Fund Patrice and Robert Americus Physician Education Debi Wheeler OHA Endowed Patient Assistance Fund Anonymous (4) The Lawrence Ellis Endowed Chair in Wendy and David Barensfeld Hematology and Oncology Pete Wheeler Parada Family Liposarcoma Research Fund Ritchie Battle The Bernard Fisher Endowed Chair in Wheeler Family Charitable Trust Surgical Oncology * deceased Michael J. Parada Research Fund Beckwith Family Foundation at the recommendation of Dotty and Nick The Foundation Endowed Pasquerilla Cancer Genomics and Beckwith and Alice and Jim* Beckwith Chair in Cancer Genetics FAMILY LEGACY SOCIETY Proteomics Research Fund Joan and Thomas Bigley The Hillman Endowed Chair in Oncology Often, a personal experience with cancer or Frank J. and Sylvia T. Pasquerilla Women’s Cancer Research Fund Mrs. Donald Blechman The Arnold Palmer Endowed Chair in the loss of a loved one to the disease spurs a Cancer Prevention family or others to establish funds that honor PNC Innovation Fund Richard M. Boccabella a patient or caregiver through support of The Pittsburgh Foundation Endowed Chair Linda Saulle Endowed Memorial Fund Mary Ann and Chuck Bogosta continuing efforts to better detect, prevent, in Innovative Cancer Research Frieda G. and Saul F. Shapira BRCA Cancer Barbara and Gary Bowser and treat cancer. The Sampson Family Endowed Chair in Research Program Nancy B. Brent, MD, and David A. Brent, MD Thoracic Surgical Oncology Suzanne Hill Alfano Endowment for The Spang Translational Research Ellen and Robert Flug Core Facility UPMC Endowed Chair in Cancer Lung Cancer Research Lisa Domenico Brooke Joseph and Giovanna Tarquinio Prevention Research Nathan S. Arenson Fund for Pancreatic Jill and Adam Brufsky, MD, PhD Cancer Research Memorial Fund UPMC Endowed Chair in Cancer Jodi and Seth Brufsky Virology Research Adriane R. Aul Memorial Fund Edward Thaw Blood Research Fund Christina and Carlos Cardoso UPMC Endowed Chair in Head and Neck The Keith F. Barket Mesothelioma Edward Underhill Memorial Fund for Susan and Alan Citron Cancer Surgical Research Research Fund Colon Cancer Research Carl Citron* UPMC Endowed Chair in Lung Beckwith Family Foundation Endowed Dr. Leonard S. Zombek Memorial Fund Cancer Research Research Scholars Program Mary and Jay Cleveland Jr. The Sandra and Thomas Usher Endowed Donald Blechman Lecture in PLANNED GIVING Sandy and Richard Cohen Chair in Melanoma Surgical Oncology University of Pittsburgh Cancer Institute, Frances and Corky Cost The Heidi Browning Endowed Ovarian partner with UPMC CancerCenter, gratefully Cary D. Cowden VISIONARY SOCIETY Cancer Research Scholars Fund acknowledges planned gifts from the Michele and Theodore Crandall, MD following individuals: These dedicated partners have given or helped Ruth C. Brufsky Fund for Clinical Research Crawford Consulting Services to raise a cumulative total of $1 million or on Pancreatic Cancer Cheryl and Bruce A. Americus Randi and L. Van V. Dauler Jr. more in support of cancer research and care. Patti Burns Fund Helen and Donald E. Chrise* Ada and George A. Davidson Jr. Al Copeland Memorial Fund for Merkel American Cancer Society, Inc. Alfred A. Dybeck Nancy E. Davidson, MD and Cell Carcinoma Research Family and Friends of Nathan S. Arenson* Susan* and Daniel Edelstone, MD Thomas Kensler, PhD Merrill J. Egorin MD Scholars Program Claude Worthington Benedum Foundation Deborah S. Feckett Rhode Jamini Vincent Davies Wayne Fusaro Pancreatic Cancer The Breast Cancer Research Foundation Karen and Joseph V. DiVito Jr. Research Fund Susan G. and Barney C. Guttman Susan and Alan Citron Sharon L. and William J. Duca* Sadie Gerson Distinguished Visiting Harriett L. and Ronald B. Herberman, MD* Carl Citron* Scholar Program Margaret M. and Jack B. Hill, MD Mary Lou and Richard Durr DSF Charitable Foundation Stuart Goodman Brain Cancer Sally E. and Peter S. Kay Susan* and Daniel Edelstone, MD Flight Attendant Medical Research Institute Memorial Fund Ms. Betty Lou Luketich Antoinette and Robert P. Edwards, MD Giant Eagle Foundation Peter E. Hackney Fund for Pancreatic George Meanor Peter G. Ellis, MD Cancer Research Teresa and The Heinz Endowments Ms. Anna Piocquidio Karen Esposito for The Paul Esposito Harvey G. Herberman, MD, Memorial Foundation for Bile Duct and Liver Cancer Harriett L. and Ronald B. Herberman, MD* Sarah and Lamont Ray Cancer Research Fund Anthony Evnin Foundation Hilda M. and Henry D. Sundermann Jr. Dr. George W. Hiett Foundation Fund Gloria L. Fader Elsie H. and Henry L. Hillman Bonnie W. and Thomas L. VanKirk, Esq. Dr. Herbert E. Jacob Memorial Fund Diane M. Faust and Barry C. Lembersky, MD Hillman Foundation Debi Wheeler Hyman I. Katz Cancer Research Fund Sheila and Milton Fine Henry L. Hillman Foundation Pete Wheeler Barbara Klump Memorial Kimberly and Curtis Fleming Family and Friends of Albert P. Knowles* *deceased Scholarship Fund Joe Fortunato New Era Cap Charitable Foundation and Frank W. Knisley Memorial Fund Family and Friends of David C. Koch* Jane France and Chris Allison Albert P. Knowles Research Fund Susan G. Komen for the Cure Gary Frazier

University of Pittsburgh Cancer Institute | 25 2012-2013 Michael Nightingale ANNUAL GIVING D. H. Bovbjerg, PhD Theresa L. Nimick-Whiteside, PhD The annual fund provides vital support for Sergey V. Boychuck DONORS Kevin Nord the operation of clinical programs, basic and John E. Boyle Stuart Nord clinical research programs, recruitment of Susan and Michael Boyle new physicians and scientists, seed money, Sandy and Gene O’Sullivan David E. Brougher, MD medical and patient education, and outreach Mr. and Mrs. John P. Friel Kit and Arnold Palmer programs. Those listed have made gifts at Richard E. Buckley Mary Louise and Henry J. Gailliot Charles H. Parker III the following levels during fiscal year 2013 Jane G. Burke and Donald S. Burke, MD Anne Gendler and David Leib Frank J. and Sylvia T. Pasquerilla (July 1, 2012, through June 30, 2013). Kimberly Ward Burns, Esq., and Merle E. and Olive Lee Gilliand Foundation Robert L. Burns Jr., Esq. LEADERSHIP CIRCLE Foundation Mr. and Mrs. Kenneth L. Payne Carl D. Cameron ($5,000 - $9,999) Lyndell* and Daniel Glosser Perlow Family Margaretha L. Casselbrant, MD Peter M. Augustine Ellen Goodman and Randy Crawford Diane and Dennis Petronko Yuan Chang, MD, and Patrick S. Moore, MD Nadine E. Bognar Shirley and Robert Gordon Jr. Dorothy L. Raizman Margaret Chavis Adam Cohen Frank and Mary Gorell Memorial Fund Rosemarie and Kiran Rajasenan, MD Richard A. Chesnik, Esq. at the recommendation of Franklyn Elizabeth and Michael Concordia David Rath Andrew J. Clark* and Dale Gorell William S. Conover II Diana and Frank Rath Gregory J. Clawson Tom Grealish Frances M. and Charles L. Cost Lillian S. Rath Barbara W. Davies and Randy A. Davies Rhonda and Glen Gross Peter J. Dellovade Jan and Don Rea Malindi Davies Sara and Alan Guttman Tarit Kanti Dutta, MD Daniel Riggs Michael A. Dean Jr. Susan and Barney Guttman Audrey Hillman Fisher Roesch Family Foundation Nicholas J. DeIuliis Gretchen and Jim Haggerty Ushaka Karumudi and Gopala Ramineni Stefania and Jeffrey Romoff Michael S. Deluca Haleski Foundation Amy M. Kelleher and Dennis J. Kelleher Scott Roy George R. Desko Andrea and Bruce* Haney Kenneth J. Kocher Athena Sarris Grace D. Dimitroff and Grayson G. Heard George J. Koenig Mikell and Bill Schenck III Douglas W. Dimitroff, Esq. Margaret and John Hill, MD Nancy S. Krieger John Martin Schneider Laura E. Doyle and Alfred P. Doyle, MD Elsie and Henry Hillman Marina Persic Lehn, Esq., and Lindsey Smail Schneider Dan S. Drawbaugh The William Talbott Hillman Foundation Kenneth M. Lehn, PhD Tracy and Evan J. Segal Lowrie C. Ebbert Cathy and Sy Holzer Janet M. Levin Deborah Shapira and Barry Stern, PhD Marjorie Edelstein The Jonathan M. Houy Memorial Fund of Jordan A. Levy Barbara and Herbert Shear Lee E. Elder The Pittsburgh Foundation Anne Lewis and C. James Zeszutek The Honorable Jacqueline O. Shogan Laura Ellsworth, Esq. Janis and Jonas Johnson, MD Shelley Lipton, PhD, and George A. Fechter Becky Burgwin and Patrick L. Kane, MD John Paxton Siebart Jeffrey Marc Lipton Shari and Stanley Finsilver Fran and David Kaplan Shirlie and Owen Siegel Foundation Amy Malaney Lilian H. Fisher Laura and Thomas Karet Sheila and Bernard Small Ann K. Newlin and William Rankin Newlin Brian J. Fritz Linda and Frank Kass Sandy and Edgar Snyder Kathleen Patrinos and Demetrios T. Patrinos Thomas P. Frizzell Tricia and Bill Kassling Patricia G. Snyder David M. Roderick Jr. Frank B. Fuhrer III Karen and Joseph L. Kelley III, MD Patricia and William Snyder Michael A. Shay William R. Gallagher Gauri Kiefer, MD, and Jan Kiefer Rebecca Cost Snyder Sheryl Simon, MD Kathleen Geffel Kathy and Cary Klein David J. Spigelmyer Jack Stabile Athan Georgiades, MD Koch Family Elaine and James Steinfurth Patricia E. Sudnik and William V. Luneburg Murry S. Gerber Valerie R. Koch Stork Foundation Laura Vassallo Paula Giglio and Martin Giglio Curtis I. Kossman Foundation Hilda and Henry Sundermann Jr. Jonathan T. Webber Mary Gillespie-Gennaula Kathryn and David A. Kowcheck Elizabeth L. and John P. Surma Lee Glunt and J. Roger Glunt Kim and Don Kramer Team Danielle – in Memory of PARTNERS FOR PROGRESS Danielle Greenburg Carlotta M. Goetz Rita Perlow Langue and Edwin D. Langue ($1,000 - $4,999) Bonnie and Tom VanKirk Sandra Green Goodman and Nathalie and Mario Lemieux Sally K. Abramo James F. Walsh Foundation Lee S. Goodman Robert Levin William J. Adams Molly E. and Joseph C. Walton Jennifer Grandis, MD, and Sally Levin Nicholas J. Alfano Donald Grandis, MD Wheeler Family Charitable Foundation Anne Lewis Jerome A. Antonacci Mary Jane Grefenstette and Debi Wheeler Christine and Jim Luketich, MD Frances A. and Charles S. Armitage Sr. Carl G. Grefenstette* Pete Wheeler Reena and Baljeet Mahal, MD Eugene Bang Edward K. Greif Sally and Craig Wolfanger Nikol and Stanley M. Marks, MD Kathryn A. Barbustiak Gary Grelick Sarah and Rob Woodings III Shirley Hobbs Martin Memorial Fund Raymond L. Barry Jr. James R. Grundtisch Robin and Gary Zentner Myrna and Mark Mason Susan J. Bartlett and David L. Bartlett, MD Roy Wyatt Haley *deceased Fran and Jim McGlothlin Colleen P. Bayko Nancy Hamilton The McKamish Family Michael Bell Charles W. Harbaugh Dani Jo and Craig McLane Thomas J. Berical Barbara A. Heigl Julie and Michael McMullen Mary H. Berkebile and Sarah Heppenstall and Jack London Berkebile Patrick McMullen C. Talbot Heppenstall Jr. Dominic N. Bertucci Katie and David McSorley Tracy G. and J. Craig Hill Astrid Bitzer and John F. Bitzer III George E. Meanor Mary L. and Thomas M. Hill Donald K. Boswell Donald A. Mosites William A. Hite

26 | UPMC CancerCenter Diane Holder and Gerald D. Holder, PhD Edward V. Randall Jr. Mindy K. Brodt Aura R. Hulme Anthony Ricottone, MD J. M. Brueggman Charlene Innocenti and John Paul Innocenti Robert W. Riordan Shannen M. Capriotti Wendy Jacobson, MD, and Louisa S. Rosenthal Christian G. Carmody Andrew H. Miller, MD Richard J. Saab, MD Dr. Denise C. Charron-Prochownik and Roy T. Johnson Robert A. Savarino Edward V. Prochownik, MD Irene Getzie Kane, PhD, and Kimberly B. Schriver Susan Levis Clancy Kevin M. Kane, MD Doris M. Scott Connie W. Cleevely and Bruce T. Cleevely John R. Kane John A. Scotti Thomas G. Cooney Sr. Robert N. Matoka Timothy L. Kane Tracy Robin Seewald, MD, and Robert W. Cruickshank John R. McConaghy, MD Daniel L. Kelly Steven A. Burton, MD Paul M. Cryder Anne B. McConnel and William O. McConnel James E. Kelly, Esq. Thomas J. Semanchik Randall S. Dearth James J. McQuade Dusty Elias Kirk Katherine A. Servich Gary Dille Barbara T. Miller and Dr. Charles J. Miller Erika P. Kirwin Patricia A. Shaffer Charles Dittman Natalie D. Miltenberger Ruth Ann Eisner Klein and Eugene J. Klein Paul R. Shine Stephanie K. Dutton Donald E. Moore Shirley M. Kottler and Richard J. Kottler Sr. Sheila Small and Dr. Bernard E. Small Mary Ellen Ferri and William A. Ferri Jr., MD Joseph T. Moran, Esq. Richard D. Lalley Shannon K. Smith and Ryan P. Smith, MD Laura K. Ferris and Robert L. Ferris, MD Edward W. Morrissey Frances S. Lancaster and Sally M. Snyder and Lee F. Snyder Brett R. Finsilver Larry A. Murdock Stewart L. Lancaster, MD Emily M. and Nicholas A. Soonthornchai Karen H. Fisher and Robert Fisher James H. Nassif Carol Larson Jeffrey W. Spear, Esq. Sally R. Fleming Patricia A. Newingham Louis E. Leff Patricia D. Staley and John A. Staley IV Steve Fox Joseph T. Newsome, DVM, DACLAM Lori E. Lesser Daniel P. Stefko James W. Fredlock Gene A. Niethamer Sandra Levin Susan R. Stewart and George L. Stewart II Anthony C. Giunta Denis L. Nolan Betsy Levine-Brown and Marc L. Brown Joyce Tese and Vincent Tese Paul Giusti Ellen M. Ormond, PhD Elsie Y. Lewis Janet Tripodi Grace Guo and Lee Peng Thomas J. Osborn Shelley Lucas and Douglas Lucas Bennet Van Houten, PhD, and William J. Hagenah Ornella Pagliano and Hassane M. Zarour, MD Robert v.d. Luft Victoria M. Woshner Walter Haleski Janice L. Pagliari and Richard A. Pagliari Julie A. Maloney and John D. Goetz, Esq. Denise K. Voloshin, MD, and Sue A. Hall Susan J. Perelman and Gregg Martin Perelman Amy and Gavin Mann Michael D. Voloshin, MD Vicki B. Hall and F. Robert Hall Jodi A. Pitchok Joan Marshall Charles B. Watson Scott J. Hamill Cathy Plesha Marjorie H. Marshall Margot L. Watt and Sebastian W. Fasanello* Robert W. Hannan Jeffrey Marc Porter James C. Martin Judith Weintraub Paula and Bradley Hencel Mary L. Ramshaw John C. Mascaro Gisela Weis and Konrad M. Weis, PhD Dwight E. Heron, MD Harold Riggle Kristen S. May and William Daniel May Patience D. Wessel Patti L. Hunt Julie S. Roberts Kevin S. McClatchy Steven S. Wilson, MD Edward W. Icardi Ann A. Rogers Jerry C. McConnell Eleanore G. Wyckoff Adele M. Jasion Sharon C. Rohr and James Edward Rohr James J. McGrath Raymond B. Wynn, MD, FACR FPOLoretta Johnson Cynthia L. Roth Thomas J. McKinney Fr. Kenneth Zaccagnini Kelly Kassab John P. Rumschik Lisa K. McLain Linda Zang John W. Keller Timothy G. Rupert Heather McMillen Wen Zhu, MD, and Min Sun, MD Joan B. Knapp Alice Salem William J. Medica *deceased Sri Kottapally, MD Paul J. Schamer Dr. Gerald Richard Medwick James V. Kunkel, MD Seth E. Schofield John L. Mehltretter CHAMPIONS John H. Kurtz III Glen E. Schumann Richard Melman ($500 - $999) Thomas A. Labert Fred Schwerer Sheila M. Mollica Stefan M. Ahlers Dan R. Lackner Carol J. Scicutella, DO, and Greg Krivacek Vickie* and Gary Morrell Margaret N. Alex and Howard M. Alex, Esq. Joseph B. Leckie Bonnie Seaton Eileen T. Moulton and Robert W. Moulton J. Rich Alexander Nancy J. Lehman and Stanley J. Lehman, Esq. Cynthia M. Shestak and Ronald V. Mumbray Jr. Mark Barbustiak Cynthia M. Leive Kenneth C. Shestak, MD Marlene Naft Marian C. Baur Claire B. Levine and Larry Levine Linda Solecki and Joseph S. Solecki, PhD Ralph Bennett Natale Dr. Patricia Beeson Henry M. Liao Paul J. Songer Steffi Oesterreich, PhD, and Bryan S. Beimel Thomas E. Lietman Kenneth James Spangler Adrian V. Lee, PhD Deborah J. Benko and Gary R. Luchini Richard A. Steinman, MD, PhD Kathleen A. Osterrieder Michael Anthony Benko Sr., DMD John R. Lucot Susan L. Stepchuk* Kathryn Ann Paladino, PhD, and Michael J. Berchou Daniel E. Luko Jr. Rachel Lockhart Stevens and Scot Stevens Peter T. Paladino Jr., Esq. Mary M. Berger Annmarie P. Lyons Lynne R. Stout Carolyn M. Patterson Sushil Beriwal, MD, and Shilpa Beriwal William J. Lyons Brian Sukitch Teresa I. Peters and Jeffery David Peters, Esq. George M. Blair Stephanie F. Mallinger and David P. Swanson Deborah L. Prentiss and Anthony M. Prentiss Patricia U. Bluestone and Bernard Mallinger, OD Dr. and Mrs. Andrzej Szymanski Donna Puleio, MD Charles D. Bluestone, MD Chronis Hazi Manolis Jeffrey J. Szymanski Dale Pysher Richard Bondi Marsha Davis Marcus, PhD, and Bradley Taback Lubna Rahman and Paul R. Brand Bernard David Marcus Mohammed Pervaiz Rahman, MD James P. Talarico Helen B. Marquard and Curtis R. Marquard Sara B. Thompson

University of Pittsburgh Cancer Institute | 27 Frank T. Datri Dale W. Kitzky Sr. Susan M. Rakfal, MD 2012-2013 Frederick J. Del Grosso Clarence E. Klaus Jr. Lisa A. Rebholz DONORS Fiore DeMarco Jonathan E. Klein Susan H. Redfield and Mary G. DiDiano Natalie Klein and Donald A. Klein John Alden Redfield, PhD Gregory R. Diekemper L. Stephen Kline John C. Regan John A. Thonet Joan DiSalle and Shannon M. Kozakiewicz and Shari L. Reynolds Dean E. Walters The Honorable Richard DiSalle Richard T. Kozakiewicz, MD Timothy J. Richmond Timothy V. Wieseckel Holly R. Dobkin and Edward J. Dobkin Alyce Kramer Susanne K. Rielly and William W. Rielly Sr. Jay E. Wildpret Amy A. Doria John M. Lally Robert Riggle Samuel C. Williamson Cynthia M. Dorundo Eileen L. Lane and Nicholas Lane Joseph G. Robinson Jr. Jian Yu, PhD, and Lin Zhang, MD Georgine A. Dorundo Jung S. Lee Samuel F. Rockwell III Jian-Min Yuan, MD, PhD Dennis M. Duda Bernice A. Leslie Brent D. Rosenthal Wendy Lee Zellner Barbara J. Dvorznak Melanie Leventon and Paul J. Leventon Edward F. Ross Jr. Thomas R. Zugger, CLU, CHRC* Sarita G. Eisner and Milton Eisner Karen J. Light Martin Ruckert *deceased Nadine M. Engel and John J. Engel Sandra Lima and Dr. Claudio Albert Jane B. Russell Thomas Esper Barbosa Lima Michael J. Ryan AMBASSADORS Thomas A. Fabiszewski Cheryl Locascio Krista Sammartino ($250 - $499) Fred P. Fanto Linda Rae Lopez and Michael A. Lopez Sr. Philip Scarola Jr. Raed S. Abdullah Mahvash Feizipour Diane E. Lucas Mark J. Schervish Benjamin J. Albu Nola Ferrari Patrick M. Lynch Michelle Schreiber Evy J. Alsaker G. Elaine Flinn and Richard A. Flinn, PhD* Ernest F. Magario Barbara B. Shapira Carita A. Anderson Robert W. Ford William H. Mallinson Michael F. Shaw Michael Anderson Ruth O. Frank Dorothy J. Mann and Scott F. Mann Donna M. Sherman Nicholas E. Andrews J. Peter Freed Margaret R. Marous, MD, and Jean M. Smith and Russell H. Smith John C. Marous III Deborah Anke Charles D. Fuhrman Lois T. Smith and Ross H. Smith Jr., MD Wendy Mars, PhD, and Peter F. Mars Donna M. Artz Heber George Marcia H. Smith and Peter A. Simon Elena Solari Masters Thomas R. Ayers Mary Louise Wolfe Gibson and Paul H. Soloff, MD Norman D. McAlister Robert A. Baker, DDS Gordon Gibson, PhD Andrea Spear and Douglas Randall Spear, Esq. Denis McAuley III Joseph D. Balsone J. Michael Gillen Marilyn Spirer and Joseph M. Spirer Althea L. McCalmont Joseph G. Belechak Dedra A. Girman Christine Stanko Eunice McCarthy and Timothy J. McCarthy Elaine Bellin Emily J. Goldberg and Richard J. Goldberg Judith A. Starr Jean H. McCullough Joanne B. Bissell and Jeffrey P. Bissell Sandra Golding Kimberly N. Stearns Amyjo F. McDade and Kevin K. McDade Frederick A. Bodnar Leslie A. Goldstein, PhD Daniel Stein Chris S. McMahon, CLU, ChFC Gary R. Borkowski Andrew J. Gorsuch Louis A. Steiner Robert M. McVicker Kathleen M. Bradey Jennifer M. Griffin and Coleman F. Griffin Tari Steinrueck John K. Means John E. Brownell Jr. Kathleen Celko Guyaux and Henry G. Stoecker Joseph Clinton Guyaux John F. Meck Rev. James L. Bruney Carolyn M. Stofko Catherine Hahn James A. Metzger, MD Elizabeth S. Burg Sharon R. Stultz John A. Hammerschmidt D. Lee Miller, MD Kristin F. Burns Paul V. Stupy Dr. Dal Soo Han F. Joseph Miller Rachel A. Caldwell Michael D. Swanson, MD James C. Hanks Andrea B. Millstein and Jack H. Millstein Jr. David W. Calvin Barbara Taback and Mitchell Harvey Taback Judith Puckett Hannon and Ryan Lee Minster, PhD, and Kathryn A. Campbell Steven M. Talak Michael John Hannon, Esq. Anthony E. Roscoe Russell I. Cann Mercedes T. Taylor John P. Hanson Jr., MD Daniel S. Monaco David A. Caperelli* Eileen J. Teslevich Michael J. Hardobey Thomas M. Mulroy, Esq. Stephanie A. Carlson Mark E. Thompson, MD Rose M. Harmon Jeffrey N. Nachman Christine Carmazzi Gayle Louise Tissue and Fred L. Herrmann Ann Marie Natishan Julius R. Casali Yiannis Kaloyeropoulos Robert E. Hoffmaster Harry Noon Jr. Matthew Cass Lynda Tunon Jean L. Hort David F. Noyes James F. Cawley, CPA Joseph L. Urban Jr. Dennis J. Hurwitz, MD John A. O’Cilka Jonathan B. Chambers N. Joseph Vaccarello Leslie S. Hyde and Louis Gerrard Santora William Ofcansky Joseph R. Chapman Walter S. Van Dyke Sandra L. Jaeger and Edward A. Jaeger, MD Nancy H. Orr Jason Chickness Diane E. Vella Richard J. James Annmarie M. Oshea-Rondeau and Frank C. Chiprich Andrew L. Vento Willard F. Jenkins Jr. David P. Rondeau Alexander J. Ciocca III Millie Vignovic William B. Kania Dominic Palombo Jr. Thomas E. Clair Suzanne P. Wagner and Richard L. Wagner David N. Kaplan Connie Parks Edwin V. Clarke Jr. William E. Wagner Peter Katz Susan A. Pasqual and Harry P. Pasqual, DMD Barbara M. Cohen John P. Waldron Thomas Kehoe Alison L. Patterson, PhD, and Elizabeth J. Cohen Kevin Russell Patterson, MD Austin Walter Renee Giovane Keil Jean E. Connell Robert F. Patton Peter B. Waltman Beatrice M. King and Michael M. King Kevin J. Conway Michael Pignatiello Margaret L. Watt-Morse, MD, MPH, and Michael King Peter M. Watt-Morse Jerilea A. Crooks and Harry M. Crooks Shannon L. Puhalla, MD, and Glen E. Puhalla Steven M. Kinney Susan E. Weintraub Barbara Crown and Robert A. Crown

28 | UPMC CancerCenter Michael J. Weinzierl Rand Corporation Bond Schoeneck and King, PLLC Kathleen A. Whelan Voices Against Brain Cancer, Inc. Bristol-Myers Squibb Company Robert W. White Century Steel Erectors ($50,000 - $99,999) Bruce E. Woodske, Esq. Champs Sports Alliance for Cancer Gene Therapy Marlene E. Yokim and John A. Yokim* Comptec, Inc. Hackers for Hope Stanley R. Yopek Jr. Cost Company National Organization for Rare Disorders Peggy A. Youree Delaware North Companies, Inc. Pittsburgh Cure Sarcoma Gregory F. Yurkoski* Deloitte Services LP Transgenomic, Inc. Claudia C. Zavodnick Eat’n Park Hospitality Group, Inc. Albert Gallatin Area High School United States Steel Corporation Paula A. Zawadzki, Esq. Eli Lilly Company Alcatel-Lucent Chad Zimmerman ($25,000 - $49,999) Elliott Ebara Group Francis L. Zimmerman , Inc. Evans Bank Anchor Seals, Inc. Dolores G. Zins Buchanan Ingersoll & Rooney FedEx Trade Networks Transport, Inc. AstraZeneca Pharmaceuticals LP Lauren Zoldan Celgene Corporation Genentech Incorporated AVI Foodsystems, Inc. Joseph J. Zwirecki Major League Baseball Genomic Health, Incorporated Bassi, McCune and Vreeland, P.C. *deceased Miles Against Melanoma 5k PA Goldman Sachs and Company BGI Millwork New Era Cap Company, Inc. USA Gordon Food Service BHNT Architects, P.C. ESTATES AND TRUSTS SomaLogic, Inc. Hatch Associates Consultants, Inc. Bison Baseball Inc. University of Pittsburgh Cancer Institute, UPMC Health Plan HealthNow New York Inc. Blue Marlin Systems Inc. partner with UPMC CancerCenter, gratefully Bronder Technical Services ($10,000 - $24,999) IBEW Local Union No. 5 acknowledges gifts from the following IBM Corporation The Brooklyn Brothers L.L.C. individual estates and trusts: Accenture LLP Corporation Active Media Services, Inc. Jones Day Estate of Alfred R. Barbour Carr Textile Corporation AEC Group, Inc. Corporation Estate of Judith E. Siegel Baum Catherine Beth Designs LLC American Brain Tumor Association Lawley Service Insurance Estate of Gladys Blackmore Chapman Properties ANH Refractories Company Lippes Mathias Wexler Friedman LLP Estate of Margaret Chavis Clean Fun Promotional Marketing, LLC Brain Tumor Society M&T Insurance Agency, Inc. Estate of Helen Colwell Cohen and Grigsby, P.C. Buffalo Bills, Inc. McGladrey LLP Estate of Francis DeLeo Curbell Concord Sierra Palmer Hotel Assoc. LP MedAssets Estate of Anne L. Haller dck worldwide, LLC Dee Dee Sacco’s Fight For Life Fund Menlo Worldwide Logistics Estate of Monsignor Walter Kachmar Dendreon Gateway Financial Group, Inc. Millennium Pharmaceuticals, George J. Kastlin Trust Incorporated Denise’s People Gray Matters Estate of Lloyd A. Kushon Milliken and Company Dickie, McCamey and Chilcote, P.C. Graycor Industrial Constructors Inc. Estate of Ralph B. Natale National Basketball Association Dow Chemical Company PAC Match Guttman Oil Company Ann Russell Trust NLMK USA Easley and Rivers, Inc. Hibiscus Biotherapeutics, Inc. Estate of John J. Shagovac Norfolk Southern Corporation Eisai Inc. Hockey Western New York LLC C. Gibson and Velma B. Shaw Trust North American Refractories Co. Evans City Elementary Middle Schools Howard Hughes Medical Institute Estate of Sara-Jane Stackpole Orbital Engineering, Inc. Fayette Regional Health System Inc. Estate of Harriet Jean Treelisky Oxford Development Company Federated Investors Incorporated Ladies Auxiliary Department Estate of Sarah King Wilmer of Pennsylvania The Philadelphia Phillies First Commonwealth Bank Millennium Pharmaceuticals Platsky Company, Inc. Fiserv Inc. BUSINESSES, CORPORATIONS, Smith Barney LLC Power Piping Company Flower Barn at Grandview Greenhouses ADVOCACY ASSOCIATIONS, AND PricewaterhouseCoopers LLP Foot Locker, Inc. OTHER GROUPS New York Yankees Oce Business Services, Inc. Race Against Cancer Freight Management Plus, Inc. University of Pittsburgh Cancer Institute, Radelet McCarthy Polletta, Inc. Georgiades Surgical Associates partner with UPMC CancerCenter, gratefully P.J. Dick/Trumbull acknowledges gifts of $250 or more from People’s Natural Gas Co., LLC Reed Smith LLP Get Noticed Promotions Inc. businesses, corporations, advocacy PGT Trucking, Inc. SAI Consulting Engineers, Inc. Gibraltar Industries associations, and other groups. Phillips Lytle LLP Sigma - Tau Pharmaceuticals, Inc. Goya Foods Great Lakes ($1 Million+) The Pink Pamper Spend a Day at the Keys Grant Channell Memorial American Cancer Society, Incorporated Pittsburgh Steelers LLC T. D. Patrinos Painting and Greater Pittsburgh Mustang Club Contracting Company The Leukemia and Lymphoma Society Plum Running Mustangs Alumni Assn., Inc. Hadley Exhibits, Inc. Tamco, Inc. Sarah Cannon Research Institute Health Research Inc ($500,000 - $999,999) The Techs Songer Steel Services, Inc. Henderson Brothers, Incorporated Life Raft Group United Parcel Service Speed Motor Express of W.N.Y., Inc. Staff of Hillman Cancer Center Vautier Communications, Inc. ($250,000 - $499,999) Tube City IMS, LLC The Hillman Company Westmoreland Country Club Tee Up Bristol-Myers Squibb Friends of Kathy Vetere Hopewell Girls Soccer Booster Assn. for the Cure Eli Lilly Company Howard Hanna Real Estate Services ($5,000 - $9,999) Women Think Pink Johnson and Johnson IBM Employee Services Center A. C. Dellovade, Inc. WPH Airport Associates Pennsylvania Breast Cancer Coalition Inferno Baseball Inc. Abbott Laboratories ($1,000 - $4,999) InStore Displays and Packaging ($100,000 - $249,999) American Textile Company AAA East Central Intermodal Air, Inc. Hawthorn Pharmaceuticals Bank of America, N.A. AK Sales, Inc. Jaeckle Fleischmann and Mugel, LLP Arnold Palmer 2005 Revocable Trust Bombardier Transportation, USA Inc.

University of Pittsburgh Cancer Institute | 29 2012-2013 Uniontown Hospital Friends of Kevin B. Butler FOUNDATIONS United Business Systems, Inc. Carlson’s Industrial Grinding, Inc. University of Pittsburgh Cancer Institute, DONORS United Steelworkers Cass Stephens Insurances partner with UPMC CancerCenter, gratefully Walsh Construction Co. Chevron Corporation acknowledges the foundations that have provided support of $250 or more to further Weavertown Transport Leasing, Inc Coraopolis Collision and our mission. James Services West Herr Automotive Group Repair Service, LLC Jendoco Construction Corporation Whemco, Inc. Cumbo Inc. $1 Million+ Jentoe Corporation Willowbrook Country Club Del Grosso Foods, Inc. Hillman Foundation Jewish Federation of Greater Pittsburgh WNED Friends of David Kronig Henry L. Hillman Foundation Jim Ludtka Sporting Goods, Inc. Woodings Industrial Corporation Friends of Pam Friedman The Pittsburgh Foundation John B. Conomos Inc Green Oaks Country Club World Wide Technology, Inc. ($500,000 - $999,999) KPMG, LLP Gurrentz International Corp Yates Fund for Cancer Hope The Breast Cancer Research Foundation Kvaerner North American Construction Harris Williams and Co. Yough High School Cheerleaders Marc Lustgarten Pancreatic Cancer L. B. Foster Company Youngstown Area Jewish Federation Index Trading and Manufacturing, Inc. Foundation Landau Building Company Z Custom Homes, Inc. Ironmaster LLC ($250,000 - $499,999) LIA Agency, Inc. Joe Jeter Sales LLC ($500 - $999) ASCO Cancer Foundation Logix Guru LLC Kamin Realty Company Association of American Doris Duke Charitable Foundation LSI Community Involvement Fund Knoechel Heating Co. Medical Colleges Ellison Medical Foundation M & T Bank Kreher Steel Company LLC B. E. A., Incorporated Susan G. Komen Breast Cancer Mascaro Construction Company, LP Learning Child Center LLC Bg Books Foundation MEDRAD, INC. Ligonier Stone and Lime Brookville Equipment Corp. James and Frances G. McGlothlin Michael Baker Corporation Concrete Company Carson City Saloon Foundation Mohawk Global Logistics LOUYAA Lightning IOU Travel Baseball CJL Engineering The V Foundation for Cancer Research Moniteau School District Employees of Magnetics Spang and Co. Environmental Management Support, LLC Wheeler Family Charitable Foundation New Alexandria Lions Club, Inc. Manheim Pittsburgh Export Fuel Co., Inc. ($100,000 - $249,999) New Era Sales Reps Massachusetts Mutual Fingertip Formulary Life Insurance Company Fashion Footwear Charitable Foundation New Pig Fraternal Order of Eagles PA Metz Lewis Brodman Must O’Keefe LLC of New York, Inc. NFL Ventures LP State Auxiliary Mock Bosco and Associates, P.C. Lymphoma Research Foundation Norwin Elks Lodge No. 2313 Gabe’s Collision Newry Self Storage Musella Foundation OMI Refractories LLC Friends of Gary Wayne Hirsch Co-workers at NIOSH Pittsburgh The Pittsburgh Foundation On LLC Industry-Railway Suppliers, Inc. Oakland Periodontal Associates, P.C. The Calihan Fund Paragon Wholesale Foods J. P. Phillips Inc Ohio State University The Jane Dolan Conover and Pennsylvania Interscholastic KFMR Katz Ferraro McMurtry, P.C. William S. Conover Fund Hockey League The Palumbo Law Group, LLC Friends of George Kratsas The Nancy T. and PL Restaurant Associates LLC Ladies Auxiliary Post 764 William S. Conover II Fund Pittsburgh Pirates Polakoff Sports Sales Inc. Laniere De Picardie, Inc. The Jane M. Epstine Charitable Fund PNC Financial Services Group, Q-Cast, Inc. Lee Industries, Inc. The Frank and Mary Gorell Incorporated Robert A Baker DDS PC Memorial Fund Little League Baseball, Incorporated Prostrakan Inc. RP Sales, Inc. The Grambrindi Davies Fund Medtronic Quality IT Partners S & T Bank The Gertrude and Hellerman Milton Fine Revocable Trust Quest Diagnostics Incorporated Towne Automotive Group Charitable Trust Fund Morrissey Wealth Management Services Relevent Tri State Supply Company, Inc. The Jonathan M. Houy Memorial Fund O’Block Jr. High School RMU Women’s Team Trover Solutions, Inc. The Limbach Family Fund Plum Borough School District RockTenn Staff of UPMC CancerCenter - Windber The McKamish Fund Pro2Serve Ross Stores, Inc UPMC Nurse Anesthesia Leadership Pittsburgh Gives 2012 Quaker Capital Management Roy F. Johns Jr. Associates Ward Transport and Logistics Corp. The Pittsburgh Gives Charitable Gift Sam-Son Distribution Center Inc. RTI International Metals, Inc. Washington High School Class of 1962 Card Program Seville Square LP RYWTF Golf Outing White Oak EMS The Theresa L. Whiteside-Nimick Fund Stanley E. Shearer CLU CHFC CASL S. M. Cristall Company, Inc. Wolf Furniture Enterprises, Inc. CLTC AEP ($50,000 - $99,999) Saint Clair Hospital South Fayette Track and Field Association Alliance for Cancer Gene Therapy Schulze and Burch Biscuit Co. Splash Water Sports, Inc. Breast Cancer Relief Foundation Search Services, LLC Uniland Development Corporation Broad Foundation Selections by Genea and Eric United Way of Westmoreland County Lung Cancer Research Foundation Sisterson and Company LLP Lymphoma Research Foundation SML Group ($250 - $499) ($25,000 - $49,999) Stantec Consulting Services Inc. Friends Neighbors of Jack B. Andrews Beckwith Family Foundation Sterling Mets, LP American Roller Bearing Company The Jack Buncher Foundation Support Technology Inc. Friends of Gala Baker Chris4Life Colon Cancer Foundation TEVA Pharmaceuticals Bayer Material Science, LLC Wallace H. Coulter Foundation The TJX Companies, Inc. Beauty Pools, Inc. Haleski Foundation Union Real Estate Company Biomedical Laboratory

30 | UPMC CancerCenter Howard Hughes Medical Institute UNITED WAY Sharon and Bob Welch The William I. & Patricia S. Snyder University of Pittsburgh Cancer Institute, Steven S. Wilson, MD Foundation partner with UPMC CancerCenter, gratefully Raymond B. Wynn, MD, FACR Charles F. Spang Foundation acknowledges donors who designated Linda Zang and Christopher David Steffy United Way donations and/or pledges of Mr. and Mrs. Theodore Zierden ($10,000 - $24,999) $250 or more in support of UPMC Children’s Brain Tumor Foundation CancerCenter and the University of ($250 - $999) Pittsburgh Cancer Institute agency codes Gailliot Family Foundation Mr. and Mrs. Stefan M. Ahlers during the 2011 and 2012 United Way and Scott A. Garet Memorial Foundation Michael Anderson United Way Campaigns (June 2012 through George B. Parous William Talbott Hillman Foundation May 2013). David E. Basinger Jodi Anne Pitchok Emma Clyde Hodge Memorial Fund Patricia Beeson, PhD ($10,000 - $24,999) Mr. and Mrs. Jeffrey Marc Porter The McKamish Family Foundation Mr. Richard Bondi Joan and Thomas G. Bigley John S. Post Frank J. and Sylvia T. Pasquerilla Patricia Borushko Foundation Kimberly and Curtis Fleming Mary L. Ramshaw Beth Ann Broudy Perlow Family Foundation Thomas B. Grealish Lisa Ann Rebholz Virginia L. Brown Riggs Family Foundation Janis and Jonas T. Johnson Shari L. Reynolds Kristin F. Burns Roesch Family Charitable Trust Nikol Snee Marks and Stanley M. Marks, MD Krista Sammartino Shannen M. Capriotti The Spencer Foundation Mr. and Mrs. Thomas L. VanKirk Michelle Schreiber Noel and Christian G. Carmody Stork Foundation Kimberly Beth Schriver ($5,000 - $9,999) Alexander J. Ciocca III Carol J. Scicutella, DO, and Frank Varischetti Foundation Elizabeth and Michael Concordia Kevin J. Conway Gregory Krivacek EQT Corporation ($5,000 - $9,999) Cynthia M. Dorundo Antonio A. Sciulli Ellen R. Goodman and Randall L. Crawford The William Brown Foundation, Inc. Diane M. Faust and Barry C. Lembersky, MD Michael F. Shaw Ann K. and William Rankin Newlin The Audrey Hillman Fisher Foundation Karen H. and Robert Fisher Sheryl Simon, MD Pittsburgh Pirates John Francis Foundation Reid J. Fleming Mr. and Mrs. Richard Skubak Mr. and Mrs. Donald C. Riefner Fraydun Foundation Inc. Dorothy E. Fukas Jeffrey L. Smoulder A Glimmer of Hope Foundation ($1,000 - $4,999) Karen and Gary Gajdzik Vincent E. Soza The Hawksglen Foundation Colleen P. Bayko Andrew J. Gorsuch Ashley N. Standard The Roy A. Hunt Foundation Michael Bell Michael J. Hardobey Robert Steen Paula and Bradley Hencel ($1,000 - $4,999) Mary H. and Jack London Berkebile Mr. and Mrs. Scot Stevens Christa Soles Hlavsa Ethel and Philip Adelman Charitable Mary Ann and Charles E. Bogosta Steven M. Talak Foundation, Inc. Kimberly Ward Burns, Esq., and Mr. and Mrs. Ralph Horne Georgiana A. Trunzo The Community Foundation for Robert L. Burns Jr., Esq. Leslie S. Hyde and Louis Gerrard Santora United States Steel the Alleghenies Christina and Carlos Cardoso Kelly and Douglas G. Kassab Mark R. Volovic George R. & Janet E. Desko Charitable Theodore L. Crandall, MD Nancy J. Lehman and Stanley J. Lehman, Esq. Dean E. Walters Foundation Fredrick K. Dalena Karen Jean Light Kathleen A. Whelan Peter C. Dozzi Family Foundation Nancy E. Davidson Ashley R. Ludwin Jay E. Wildpret The Matthew Hillman Fisher Foundation, Inc. Roseann DeGrazia Mr. and Ms. Michael W. Lyons Russell T. Williams The Foundation For Jewish Philanthropies Michael S. Deluca Marsha D. Marcus, PhD, and Wendy Lee Zellner Fountainhead Foundation Mr. Bernard David Marcus Amy and Rob DeMichiei Patricia A. and W. Dennis Zerega, EdD Shawn Gaertner Foundation Dan S. Drawbaugh Mr. and Mrs. Marc D. Marks The Gordon Foundation Stephanie K. Dutton Norman D. McAlister UPMC CANCERCENTER AND Homebuilding Community Foundation Mr. and Mrs. Craig Fiedler Mr. and Mrs. Timothy J. McCarthy THE UNIVERSITY OF PITTSBURGH CANCER INSTITUTE The M & T Charitable Foundation Brian J. Fritz Phillip McGuire DEVELOPMENT DEPARTMENT James S. McDonnell Foundation Mr. and Mrs. John Galley James J. McQuade Jennifer Raetz, Development Director Shadyside Hospital Foundation Stephany Hartstirn Ann Marie Natishan Kambra McConnel, Major Gifts Officer The Shore Fund Diane and Gerald D. Holder, PhD Brett W. Neuberger Paula Hencel, Major Gifts Officer The Juliet Lea Hillman Simonds Mr. and Mrs. John Paul Innocenti Patricia A. Newingham Foundation, Inc. Lisa Costa, Program Manager Mr. and Mrs. Edward T. Karlovich Rachel and Eric Newman Vanguard Charitable Endowment Eleanor Flannery, Administrative Coordinator Scott M. Lammie Theresa L. Nimick-Whiteside, MD ($250 - $999) Dr. Stewart Lancaster Jewish Healthcare Foundation Shelley and Douglas J. Lucas of Pittsburgh James D. Luketich, MD The Judith A. Lese Breast Cancer Kristen S. and William Daniel May Foundation, Inc. Every gift to UPMC CancerCenter and the University of Mr. and Mrs. Martin McGuinn The E.V. Randall, Jr. Family Fund Joyce Metnick Pittsburgh Cancer Institute plays a vital role in advancing Sanford N. & Judith Robinson Family Mr. and Mrs. Howard Sniderman research and enhancing patient care. Unfortunately, space Foundation Lenette M. and Francis X. Solano Jr., MD is too limited to list the individual names of the many donors Stacy and Don Splitstone Jeffrey J. Szymanski who gave gifts at levels of $1 to $249. Please know your Janet Tripodi support is truly appreciated. If we have made any errors in Charles B. Watson any name or omitted anyone from this list, please accept our apologies and notify us by calling 412-623-4700.

University of Pittsburgh Cancer Institute | 31 BRIEFS

UPCI hosts Pennsylvania Cancer Planning Summit to address cancer needs in the state

On April 11, 2013, UPMC CancerCenter and strove to address the specific cancer UPCI hosted more than 200 representatives needs of Pennsylvania residents, ensuring in dozens of oncology fields from across homegrown action. Pennsylvania to develop a new cancer control plan for Pennsylvania. Stakeholders gathered in the Herberman Conference Center at UPMC Cancer Pavilion, “Building Bridges: Pennsylvania Cancer UPMC Shadyside, to discuss statewide and Planning Summit” was coordinated by the national perspectives on cancer. Smaller Pennsylvania Department of Health in breakout sessions focused on epidemiology conjunction with the Pennsylvania and surveillance, interventions, Cancer Control, Prevention, environmental approaches, and and Research Advisory community and clinical links, Board. The five-year plan including initiatives to promote is required by the cancer health equity for Center for Disease all, the implementation Control and Prevention. of evidence-based Although the group interventions, and used the CDC’s sustaining programs guidelines to set the created under the new plan. tone, representatives

New Joint Ventures Bring Advanced Cancer Care to Butler County

In an effort to increase access to high-quality Butler Health System Radiation Oncology Complementing these services, Butler oncology care north of Pittsburgh, UPMC welcomed patients in April 2013. The Health System Medical Oncology, located in CancerCenter partnered with Butler Health joint venture acquired Butler Radiation newly renovated space in Butler Memorial System (BHS) in 2013 to form Butler Health Oncology Associates, along with two Hospital, opened its doors in July 2013. System Medical and Radiation Oncology, well-respected radiation oncologists from Recently recruited medical oncologist and bringing one of the nation’s most advanced the practice, Victor Onufrey, MD, and hematologist Rushir J. Choksi, MD, provides cancer treatment networks to patients in the Hung-Chi Ho, MD, who work in conjunction consultations, and chemotherapy and Butler region. with UPMC CancerCenter experts to biotherapy treatments. deliver advanced radiation technology and comprehensive care.

32 | UPMC CancerCenter The University of Pittsburgh Cancer Institute, working in conjunction with UPMC CancerCenter, UPMC’s clinical care delivery network, is western Pennsylvania’s only National Cancer Institute (NCI)-designated Comprehensive Cancer Center, reflecting the highest level of recognition by NCI.

Annual giving donors listed are from Fiscal Year 2013.

Circle of Hope donors listed are from calendar years 2012 and 2013, as of August 21, 2013. UPMC CancerCenter, partner with University of Pittsburgh Cancer Institute

NONPROFIT ORG U.S. POSTAGE PAID PITTSBURGH, PA PERMIT NO. 3834 A publication of UPMC CancerCenter, partner with University of Pittsburgh Cancer Institute

UPMC Cancer Pavilion 5150 Centre Ave. Pittsburgh, PA 15232 UPMCCancerCenter.com

UPMC CancerCenter connects patients to the integrated expertise of leading clinicians, academic researchers, specialty programs, and treatment centers. By partnering with the University of Pittsburgh Cancer Institute (UPCI), designated as a Comprehensive Cancer Center by the National Cancer Institute (NCI), we are accelerating the breakthroughs in our labs into clinical practice around the world. Backed by the collective strength of UPMC and UPCI, UPMC CancerCenter is revolutionizing cancer research, care, and prevention — one patient at a time.

For information about supporting cancer research efforts and patient care at UPMC CancerCenter and the University of Pittsburgh Cancer Institute, contact us at 412-623-4700.

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