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Overcoming the Innate Resistance of Cancer To The Pezcoller Foundation Symposia General information Accommodation in Trento • Hotel Buonconsiglio - via Romagnosi - Scientific Secretariat th Ph. +39 0461 272888 - www.hotelbuonconsiglio.com 30 Pezcoller Symposium Fondazione Pezcoller Via Dordi, 8 – 38122 Trento (Italy) • Hotel America - Via Torre Verde - Ph. +39 0461 983010 Phone +39 0461 980250 www.hotelamerica.it OVERCOMING THE INNATE E-mail: [email protected] • Grand Hotel Trento – Piazza Dante - Ph. +39 0461 271000 30th Pezcoller Symposium RESISTANCE OF CANCER Web: www.pezcoller.it www.grandhoteltrento.com TO THERAPY • Hotel Everest – Corso degli Alpini, 14 - Trento, Italy Organizing Secretariat Ph +39 0461 825300 - www.hoteleverest.it June 25-26, 2018 OriKata organizzazione congressi • Hotel Accademia - Vicolo Colico - Ph. +39 0461 233600 OVERCOMING THE phone +39 0461 824326 www.accademiahotel.it Congress Hall fax +39 0461 824251 • Hotel Garnì Venezia - P.za Duomo - Ph. +39 0461 234559 INNATE RESISTANCE Federazione Trentina della Cooperazione e-mail [email protected] www.hotelveneziatn.it Via Giovanni Segantini, 10 - 38122 Trento, Italy • AlberMonaco - Via Torre d’Augusto - Ph. +39 0461 983060 OF CANCER Head of Scientific Committee: Location www.albermonaco.com David M. Livingston Congress Hall - Federazione Trentina della Cooperazione - TO THERAPY Via Giovanni Segantini, 10, 38122 Trento Chairpersons: -------------------------------------------------- Trento, Italy Alberto Bardelli, Massimo Loda, Pier Paolo Pandolfi, Stefano Piccolo Registration and fees Congress location (*NEW LOCATION) June 25-26, 2018 Registration modality: online on Pezcoller Foundation website * walking distance from hotels, parking areas and city center and within 9th June 2018. Congress Hall - Federazione Trentina della Cooperazione Registration fee: € 244,00 (VAT 22% included) Focus and Goals: Currently, oncologists and cancer scientists face The fee includes: participation to the symposium, congress Via Giovanni Segantini, 10 - 38122 Trento an abiding problem of major proportion, namely the emergence of resistance of certain cancers-some very common- to any therapy kit, working lunches, coffee breaks, symposium dinner and The congress venue has no private parking spots during their course. For some of these tumors, such as melanoma transfer by bus. The dinner will take place in Mezzocorona available. and kidney cancer, immune therapy has shown remarkable effects, (Cantine Rotari) on 25th June. The nearest parking areas are: Garage Centro Europa but only a small fraction of patients undergo extended therapeutic Participation for researchers, collaborators, employees of responses. For prostate cancer patients whose tumors develop an- local Research Centers (University of Trento and Public (via Giovanni Segantini, 7) and Garage Autosilo ti-androgen therapy resistance, further therapy has largely failed. And Buonconsiglio (Via Francesco Petrarca, 1/5). for cancers like Glioblastoma, pancreatic cancer, mesothelioma, and Institutions of the Autonomous Province of Trento) is free of chemotherapy and marrow transplant-resistant acute myelogenous charge. leukemia, a pathway to therapeutic success is not yet apparent. The Map thrust of this meeting will be to explore the molecular and biological sources of historical therapeutic resistance in these cancers and to Posters assess the most promising opportunities for overcoming it. We encourage poster presentation. To submit a poster send a one page abstract to the Pezcoller Foundation ([email protected]) by May 22nd. The 3 best posters will be selected for the This Symposium is supported by Begnudelli Awards. You are encouraged to prepare Fondazione PEZCOLLER - Fondazione CARITRO a short power-point presentation in case of award. Via Dordi, 8 - Provincia Autonoma di Trento 38122 TRENTO - Italy Poster maximum size: m 1,00 width – m 1,00 Tel. 0039 - 0461 - 980250 - Comune di Rovereto height Fax 0039 - 0461 - 980350 E-mail: [email protected] Web: www.pezcoller.it 7 8 2 The Pezcoller Symposia The Pezcoller Symposia The Pezcoller Symposia Program Program Faculty Discussants MONDAY JUNE 25, 2018 TUESDAY, JUNE 26, 2018 • Bardelli Alberto • Børresen-Dale Anne-Lise 8:00 Registration Candiolo Cancer Institute, University of Torino, Italy Institute for Cancer Research, The Norwegian Radium Session 4 - Therapeutically resistant Melanoma Hospital, Oslo N 8:30 Enzo Galligioni Welcome Chairman: Stefano Piccolo • Berns Anton 8:40 David Livingston Focus & Goals Netherland Cancer Institute, Amsterdam, Holland • Bracarda Sergio 08.30 David Fisher Medical Oncology Department, General Hospital, Arezzo, The Enrico Mihich Lecture • Dirks Peter Melanoma: clues to therapeutic efficacy from disease Italy 8:50 Harold Varmus pathogenesis The Hospital for Sick Children, Toronto, Ontario, Canada • Colombo Mario Pezcoller at 30: Cancer Research, Then and Now 08.55 Ugur Sahin • Falini Brunangelo Molecular Immunology, Fondazione Istituto Nazionale dei 9.35 Discussion Personalized cancer immunotherapy Institute Of Hematology, University of Perugia, Italy Tumori, Milan, Italy 09.20 Discussion led by Alberto Mantovani and Mario Colombo • Fisher David Session 1 - Pancreas Cancer • Demichelis Francesca Massachusetts General Hospital, Charlestown, MA Chairman: Alberto Bardelli Session 5 - Glioblastoma Centre for Integrative Biology, University of Trento, Italy • Iacobuzio-Donahue Christine 09.50 David Tuveson Chairman: Stefano Piccolo • Giangaspero Felice Memorial Sloan Kettering Cancer Center, New York, NY Improving pancreatic cancer response to therapy 10.00 Peter Dirks Policlinico Umberto I, Università La Sapienza Roma, Italy • Josey John 10.15 Christine Iacobuzio-Donahue Dissecting brain tumour cell fate with functional • Mantovani Alberto Peloton Therapeutics Inc, Dallas, TX Evolutionary dynamics of cancer approaches Humanitas University, Milan, Italy 10.25 Ingo Mellinghoff • Kaelin G. William 10.40 Discussion led by Giampaolo Tortora • Melisi Davide Targeting aberrant signaling in primary brain tumors Dana-Farber Cancer Institute, Boston, MA and Davide Melisi Medical Oncology, University of Verona, Italy 11.20 Coffee Break 10.50 Discussion led by Felice Giangaspero • Loda Massimo • Tortora Giampaolo 11.30 Coffee Break Dana-Farber Cancer Institute, Boston, MA Session 2 - Leukemia Medical Oncology, University of Verona, Italy Chairman: Alberto Bardelli Session 6 - Kidney Cancer • Mellinghoff Ingo Chairman: Massimo Loda Memorial Sloan Kettering Cancer Center, New York, NY 11.30 Brunangelo Falini – Enrico Tiacci • Livingston David 11.40 William Kaelin BRAF inhibition in hairy cell leukemia: biological Dana-Farber Cancer Institute, Boston, MA and clinical aspects New models and treatments for clear cell renal cell The Pezcoller Foundation 11.55 Pier Paolo Pandolfi carcinoma • Pandolfi Pier Paolo Modeling resistance identifies vulnerabilities and 12.05 John Josey Division of Genetics Beth Israel Deaconess Medical Center, The Pezcoller Foundation is a non-profit organisation created in effective combination therapy in mIDH AML Inhibiting the transcriptional factor HIF-2α:treatment Boston, MA 1980 by Prof. Alessio Pezcoller (1896 - 1993), Chief Surgeon at 12.20 Discussion led by Pier Paolo Pandolfi of renal cell carcinoma and VHL disease • Piccolo Stefano Santa Chiara Hospital of Trento, Italy. The goal of the Founda- 13.00 Lunch 12.30 Discussion led by William Kaelin and John Josey Molecular Medicine Department, University of Padova, Italy tion is to promote biomedical research. 13.10 Lunch • Poirier John T. Activities: Session 3 - Prostate Cancer Memorial Sloan Kettering Cancer Center, New York, NY • PEZCOLLER FOUNDATION-AACR INTERNATIONAL Chairman: Pier Paolo Pandolfi Session 7 - Mesothelioma and Small Cell Lung Cancer AWARD FOR EXTRAORDINARY ACHIEVEMENTS IN • Sahin Ugur Chairman: Alberto Bardelli CANCER RESEARCH 14.00 Charles Sawyers BioNTech AG, University of Mainz, Germany • PEZCOLLER FOUNDATION-EACR CANCER Cancer drug resistance 14.10 Anton Berns • Sawyers Charles RESEARCHER AWARD 14.25 Massimo Loda Mouse models of thoracic cancers. Phenotypic consequences of their cell-of-origin Memorial Sloan Kettering Cancer Center, New York, NY • THE PEZCOLLER SYMPOSIA Effect of the microenvironment on prostate cancer • PEZCOLLER SEMINARS biologic and clinical behavior 14.35 John Poirier • Tiacci Enrico Molecular mechanisms of acquired chemoresistance in Hematology Department, University of Perugia, Italy • PEZCOLLER FOUNDATION FELLOWSHIPS 14.50 Discussion led by Francesca Demichelis and Sergio small cell lung cancer • PEZCOLLER FOUNDATION GRANTS Bracarda • Tuveson David • THE PEZCOLLER FOUNDATION JOURNAL 15.30 Poster Session 15.00 Discussion led by Anne-Lise Borresen-Dale and Cancer Center Cold Spring Harbor Lab, Cold Spring, NY Alberto Mantovani Under the patronage of 16.30 Adjourn • Varmus Harold 15.40 Poster Discussion and Poster Presentation led by Weill Cornell Medicine Meyer Cancer Center, New York, NY 18.00 visit to Mezzacorona Winery (shuttle transportation Massimo Loda provided) 16.40 David Livingston 20.00 Symposium Dinner at Mezzacorona Winery Concluding Remarks 3 4 5 6 The Pezcoller Symposia The Pezcoller Symposia The Pezcoller Symposia The Pezcoller Symposia.
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