ROUZINE, IGOR
Igor M. Rouzine UMR 7238 CNRS "Biologie Computationnelle et Quantitative" Sorbonne Université (Université Pierre et Marie Curie) Institut de Biologie Paris Seine Case courrier 1540 4 rue Jussieu, Paris 75005 https://www.ibps.upmc.fr/fr/Recherche/umr- 7238/evolution-immunologie-pathogenes http://www.lcqb.upmc.fr/users/rouzine [email protected] [email protected]
Phone: + 33 7 60 85 90 59
Nationality: American
Current position, May 1 2017 - present
Visiting Professor and Group Leader Group "Evolution and Immunology of Pathogens" Laboratory of Computational and Quantitative Biology Institut de Biologie Paris-Seine, Paris
Diplomas 1985 M.S., Theor. Semicond. Physics, Electrical Engineering Institute, St. Petersburg, Russia 1988 Ph.D., Theor. Semic. Physics, Ioffe Physico-Technical Institute, St. Petersburg, Russia
Academic appointments
2015-2017 Specialist, Microbiology, University of California, San Francisco 2012-2015 Staff Scientist, The Gladstone Institute of Virology and Immunology, San Francisco 2007-2011 Research Associate Professor, Department of Molecular Biology and Microbiology, Tufts University, Boston 2001-2007 Research Assistant Professor, Department of Molecular Biology and Microbiology, Tufts University, Boston 1996-2000 Research Associate, Department of Molecular Biology and Microbiology, Tufts University, Boston 1993-1995 Postdoctoral (Research) Associate, Department of Physics, University of California, Los Angeles ROUZINE, IGOR 1990-1993 Postdoctoral (Research) Associate, Theoretical Physics Institute, University of Minnesota, Minneapolis 1985-1990 Researcher, Theoretical Department, A.F. Ioffe Physical Technical Institute, St. Petersburg, Russia
Languages: English fluent, Russian native, French advanced, German intermediate, Italian elementary
Visiting positions
Theoretical Biology: Pekin University, Bejing, China: April 2016, Center for Quantitative Biology UPMC, Paris, France: October 1 - November 7th 2015; Laboratory of Computational and Quantitative Biology, UMR 7238 CNRS-UPM University of Cologne, Germany: October 1-December 31, 2011; Department of Physics Gladstone Institute of Virology and Immunology, San Francisco, CA, USA: August-September, 2011; University of California at San Francisco, USA University of California at San Diego, CA, USA: June-July, 2011: Department of Chemistry and Biochemistry, La Jolla, CA, USA Kavli Institute for Theoretical Physics: February, 2011; Workshop on Microbial Evolution, University of California at Santa Barbara, CA, USA Theoretical Physics: Harvard University: March and June-August, 1995, Department of Physics, Boston, USA Leiden University: April-May, 1995; Department of Physics, Leiden, Netherlands
Research areas Computational and theoretical biology Dynamics and evolution of pathogen infections Semiconductor Physics
Associations and service 2018-2019: Guest Editor of Pathogens 2006-2009: Associate Editor of the Journal of Mathematical Analysis and Applications 2015-2017: Member of the Society for Mathematical Biology 2013-2016: Member of the American Mathematical Society 1990-1995: Member of the American Physical Society
Teaching 2017-2019: Instructor in Evolution Modeling for third-year students of Sorbonne-Polytech, Paris ROUZINE, IGOR 2013: Adjunct Professor in Astronomy for business majors, University of San Francisco 1995: Lecturer in Electricity and Magnetism for CS and EE majors, University of California at Los Angeles Public lectures: 2018-2020, la Fête de la Science, Sorbonne Université Campus Pierre et Marie Curie, Paris, https://www.sorbonne-universite.fr/les-lois-de-la-selection-naturelle
Reviewer for international journals AIDS Research Retroviruses Journal of Virology American Naturalist Lancet Microbe BMC Evolution Nature BMC Microbiology Nucleic Acid Research Bulletin of Mathematical Biology Pathogens Cell Proceedings of National Academy of Critical Reviews of Microbiology Sciences of USA EMBO PLoS Computational Biology Genetics PLoS Pathogens Genes PLoS Genetics Evolutionary Applications PLoS ONE Frontiers of Immunology Theoretical Population Biology Journal of Statistical Mechanics Physical Review Letters Journal of Theoretical Biology Physical Review B
Reviewer for grants Vici grant proposal, Hague, Netherlands, 2020 NIH research grant proposal (R01), 2011 NIH research grant proposal (R01), 2012 Vienna Research Group grant proposal for Young Investigators, 2012
Grants received 2017-2021: ANR grant "Hosting high-level researchers", $600,000 direct expenses Title: "The fusion of modeling and data analysis to study the evolution of pathogens" Host organization: UPMC, Paris Role: Principal Investigator 2016-2020: Grant DARPA-BAA-16-35--INTERCEPT, USA, $273 000 Role: Co-PI (with Raul Andino, University of California San Francisco) 2014-2016: grant R21AI109611 from National Institutes of Health, $500,000 total Title: "Experiment & theory to test an evolutionary fitness role for lentiviral latency" Role: Co-Principal Investigator (with Leor Weinberger, Gladstone Institutes) 2006-2010: grant R01AI063926 from National Institutes of Health, USA, $1000,000 total Title: “Working models of HIV persistence and evolution”. Role: Principal Investigator 2001-2005: grant K25AI01811 from National Institutes of Health, USA, $600,000 total Title: “Search for working models of HIV persistence and evolution”. ROUZINE, IGOR Role: Principal Investigator
Invited talks at seminars and conferences (22 total) 2021: Seminar "Progression to AIDS and HIV controllers", University of Heidelberg, Germany 2020: Seminar "Progression to AIDS and HIV controllers", University of Montpelier, France 2019: Nordita workshop "From Molecular Basis to Predictability and Control of Evolution", Stockholm, Sweden. 2018: 3d IFOM Symposium "Evolution, Resistance, and Cancer", IFOM, Milan, Italy. 2015: 5th Interdisciplinary Symposium "Genomics and Microbial Communities", Institut de Biologie Paris-Seine, UPMC, Paris 2015: Two seminars on an evolutionary role of HIV latency: Groupe de Travail math / bio, UPMC, Paris, et Biophysique, Institut Curie, Paris 2015: Seminar on an evolutionary role of HIV latency, IBM, Almaden Research Center, San Jose, CA 2014: Seminar on modeling HIV evolution caused by the host immune response, IBM, Almaden, CA 2014: Program "Evolution of Drug Resistance", Kavli Institute of Theoretical Physics, University of California at Santa Barbara, CA 2014: "Workshop on From Within-Host Dynamics to the Epidemiology of Infectious Disease", Institute of Mathematical Biosciences, Columbus, Ohio 2014: Seminar on therapeutic inteference particles, Institute of Biology, Paris Seine, UPMC, 2012: Workshop on Discrete and Topological Models in Molecular Biology and AMS special session on Discrete Models in Molecular Biology, University of Florida, Tampa, FL, USA 2011: Seminar on modeling immune response against influenza, Department of Physics, University of Exeter, Exeter, UK 2011: Workshop on Microbial Evolution, Kavli Institute for Theoretical Physics, University of California at Santa Barbara, Santa Barbara, CA, USA 2010: Seminar on evolution theory, The National Evolutionary Synthesis Center, Duke University, Durham, NC, USA 2009: International 3rd Eastern European and Central Asia AIDS Conference, Moscow, Russia 2007: Workshop on Theoretical Immunology, University of Leuven, Belgium 2006: Workshop on Mathematical Population Genetics, Edinburgh, UK 2006: Seminar on evolution theory, Department of Evolution and Ecology, University of California at Davis, CA, USA 2006: Two seminars on evolution theory and modeling HIV immunology, Department of Physics, University of California at San Diego, CA, USA 2005: Seminar on modeling HIV immunology, Centre for Non-Linear Dynamics, Department of Physiology, McGill University, Montreal, Canada 2004: Seminar on asexual evolution, Department of Biostatistics, University of California at Los Angeles, CA, USA 2004: Seminar on evolution and dynamics of HIV at A.F. Ioffe Physical Technical Institute, St. Petersburg, Russia 2003: Seminar in Genomics Center, Harvard University, Cambridge, MA, USA ROUZINE, IGOR 2002: Seminar on evolution theory of asexual populations, Department of Applied Mathematics, Massachusetts Technological Institute, Cambridge, MA, USA 2002: Seminar on evolution theory of asexual populations, Department of Physics, Harvard University, Cambridge, MA, USA 1998: Meeting on HIV Dynamics and Evolution, organized by University of California at San Diego 1995: Seminar on antigenic escape of HIV from the immune response, Department of Microbiology, University of California, CA, USA
Other conferences (~40 total)
2012-2013: 4 seminars and 6 talks at the University of California at San Francisco (outside of the lab) 1996-2012, Biology: 20+ conferences including annual series: Meeting on HIV evolution and dynamics (organized by UCSD, La Jolla, CA, USA) Retroviruses (Cold Spring Harbor, NY) Conference on Retroviruses and Opportunistic Infections Keystone meetings at Keystone, Colorado, and Banff, Alberta, Canada 1990-1995, Physics: 8-9 conferences including annual series: Meeting of American Physical Society Aspen Workshop on Condensed Matter Theory, Aspen, Colorado
Instruction of graduate and postdoctoral students 2020: Luis Pereira, postdoctoral associate, Sorbonne Université Campus Pierre et Marie Curie, Paris 2018: Ayuna Barlukova, postdoctoral associate, Sorbonne Université Campus Pierre et Marie Curie, Paris 2017-2019: Gabriele Pedruzzi, postdoctoral associate, Sorbonne Université Campus Pierre et Marie Curie, Paris 2014-2015: Ariel Weinberger, collaborator and postdoctoral fellow at Harvard University 2013-2015: Luke Rast, intern, Gladstone Institute of Virology and Immunology, University of California, San Francisco 2012: Lisa Bishop, postdoctoral associate, Gladstone Institute of Virology and Immunology, University of California at San Francisco 2008-2012: Rebecca Batorsky, graduate student, Department of Physics at Tufts University, Boston. (Later employment: Ragon Institute, Harvard-MIT-MGH, Boston) 2006-2009: Rinat Sergeev, postdoctoral associate, Department of Molecular Biology and Microbiology, Tufts University. (Current employment: Institute for Quantitative Social Science, Harvard University) 2007-2008: Elena Gubankova, postdoctoral associate, Department of Molecular Biology and Microbiology, Tufts University ROUZINE, IGOR 2003-2005: Speranta Gheorghiu, postdoctoral associate, Department of Molecular Biology and Microbiology, Tufts University
Collaboration with experimental teams
My modeling of evolution and immunology enlisted support from experimental groups, as follows: • Georges Luftalla, University of Montpellier • Olivier Lambotte, Hopitale Bicêtre, Paris • Marco Vignuzzi lab, Pasteur Institut, Paris • Raul Andino lab, Department of Microbiology and Immunology, University of California at San Francisco • Weinberger lab of Synthetic and quantitative virology, Gladstone Institute of Virology and Immunology, San Francisco • Coffin lab of Retrovirology, Department of Molecular Biology and Microbiology, Tufts University, Boston • John Coffin, Director (now Special Consultant), the HIV Drug Resistance Program at National Cancer Institute, NIH, Frederick, DC, USA • Novella lab of RNA virus evolution, College of Medicine, University of Toledo, Toledo, OH, USA • Letvin lab of Simian immunodeficiency virus pathogenesis, Beth Israel Deaconess Medical Center, Harvard University, Boston • Rafi Ahmed, Director, Emory Vaccine Center, Atlanta, GA, USA ROUZINE, IGOR
BIBLIOGRAPHY Results beyond the state-of-art
Rouzine* IM, Wakeley J, Coffin JM (2003) The solitary wave of asexual evolution. Proc Nat Acad Sci 100: 587-592 The first accurate mathematical analysis predicting the evolution rate of a population with a large number of linked loci in the absence of recombination.
Rouzine IM, Weinberger, AD, and Weinberger*, LS (2015) An evolutionary role for HIV latency in enhancing viral transmission. Cell 160, 1002–12 An evolutionary role for HIV latency is a Trojan horse effect during transmission.
Rouzine* IM, Coffin JM (2001) Transition between stochastic evolution and deterministic evolution in the presence of selection: general theory and application to virology [review]. Microbio Mol Bio Rev 65: 151-185 The classical stochastic theory of evolution 1930-1970 is reviewed and adapted for virology.
IM Rouzine (2020) An evolutionary model of progression to AIDS. Microorganisms 8, 1714 https://doi.org/10.3390/microorganisms8111714 The first closed model of progression to AIDS is proposed based on gradual adaptation of HIV to a host is proposed.
Good BH, Rouzine IM, Balick DJ, Hallatschek O, and Desai* MM (2012) Distribution of fixed beneficial mutations and the rate of adaptation in asexual populations. Proc Natl Acad Sci U S A 109: 4950-4955 The traveling wave theory is generalized for the arbitrary distribution of mutational fitness effects.
Rouzine* IM and Rozhnova G (2018) Antigenic evolution of viruses in host populations. PLoS Pathogens 14, e1007291 A model of genetic evolution of a virus in a host population accumulating the immune memory connects epidemiology to immunology and the modern evolution theory. The predicted parameters are tested against data for influenza A.
Batorsky R, Kearney MF, Palmer SE, Maldarelli F, Rouzine* IM, Coffin JM (2011) Estimate of effective recombination rate and average selection coefficient for HIV in chronic infection. Proc Natl Acad Sci U S A 108: 5661 Rouzine* IM, Coffin JM (1999) Linkage disequilibrium test implies a large effective population number for HIV in vivo. Proc Nat Acad Sci 96: 10758-10763 The effective population size and the effective recombination rate of HIV are estimated correctly for the first time.
Rouzine* IM, Coffin JM (2005) Evolution of HIV under selection and weak recombination. Genetics 170: 7-18 Rouzine*, IM, and Coffin, JM (2010) Many-site adaptation in the presence of infrequent recombination. Theor Pop Bio 77: 189-204 Recombination is incorporated in the modern multi-locus evolution theory
Rouzine* IM, Coffin JM (1999) Search for the mechanism of evolution in the pro gene of HIV in vivo. J Virol 73: 8167- 8178. The high diversity of HIV within and between infected individuals is explained as a result of compensatory mutations for the early escape mutations in CD8 T cell epitopes. The average value of the effective selection coefficient for HIV patient is estimated.
Rouzine* IM, McKenzie FE (2003) Link between immune response and parasite synchronization in malaria. Proc Nat Acad Sci 100: 3473-3478 Chaotic oscillations of parasitemia in malaria are predicted as a result of communication between different parasites in different phases of cell replication.
ROUZINE, IGOR Books (1 total) Rouzine IM. (2020) "Mathematical Models of Evolution. Volume 1: One-locus and multi-locus theory and recombination", in series Mathematics and life sciences, De Gruyter, Berlin/Boston.
Book chapters (3 total)
* Auteur correspondant Rouzine* IM, Coffin JM (1999) Interplay between experiment and theory in development of a working model for HIV-1 population dynamics, in: Origin and Evolution of Viruses, eds. E.Domingo, R.Webster and J.Holland, Academic, London, 1999, pp.225-262. Raikh* ME, Ruzin IM (1991) Transmittance fluctuations in randomly non-uniform barriers and incoherent mesoscopics, review, in: Mesoscopic Phenomena in Solids, eds. B.L.Altshuler, P.A.Lee and R.A.Webb. North Holland, Amsterdam, 1991, pp. 301-354. Raikh* ME, Ruzin IM (1990) Distribution function of conductance of finite-size inhomogeneous barrier structures, in: Hopping and Related Phenomena, eds. H.Fritzsche and M.Pollak. World Scientific, Singapore, 1990, pp. 217-241. https://www.worldscientific.com/doi/abs/10.1142/9789814434447_0017
Peer-reviewed publications (63 total) Computational and theoretical biology
Barlukova A, Rouzine* IM (2021) The evolutionary origin of the universal distribution of mutation fitness effect. PLOS Comp. Bio. 17, e1008822 IF 4.0 Rouzine IM (2020) An evolutionary model of progression to AIDS. Microorganisms 8, 1714 IF 4.2 Pedruzzi G, Rouzine IM * (2019) Epistasis detectably alters correlations between genomic sites in a narrow parameter window. PloS ONE 14, e0214036 IF 4.0 Pedruzzi G, Barlukova A, Rouzine* IM (2018) Evolutionary footprint of epistasis. PLoS Computational Biology 14, e1006426. IF 4.0 Rouzine* IM, Rozhnova G (2018) Antigenic evolution of viruses in host populations. PLoS Pathogens 14, e1007291. IF 6.2 Lidsky PV, Andino R *, Rouzine IM (2017) Variability in viral pathogenesis: modeling the dynamic of acute and persistent infections. Current Opinion in Virology 23, 120-124. IF 5.6 Xiao Y, Rouzine IM, Bianco S, Acevedo A, Goldstein EF, Farkov, M, Andino M *. RNA recombination enhances adaptability and is required for virus spread and virulence (2016). Cell host & microbe 19 (4), 493-503. IF 17.9 LI Rast, IM Rouzine, G Rozhnova, L Bishop, AD, Weinberger*, LS. Conflicting selection pressures will constrain viral escape from interfering particles: principles for designing resistance-proof antivirals (2016). PLoS Computational Biology 12 (5), e1004799. IF 4.0 ROUZINE, IGOR Rouzine, IM, Weinberger, AD, and Weinberger*, LS (2015) An evolutionary role for HIV latency in enhancing viral transmission. Cell 160, 1002–1012. IF 31.4 Razooky, BS, Pai, A, Aull, K, Rouzine, IM, and Weinberger*, LS (2015) A hardwired HIV latency program. Cell 160, 990–1001. IF 31.4 Batorsky, R, Sergeev, RA, Rouzine*, IM (2014) The route of HIV escape from immune response targeting multiple sites is determined by the cost-benefit tradeoff of escape mutations. PLoS Comp. Bio. 10, e1003878. IF 4.0 Rouzine IM, Razooky, BS, Weinberger*, LS (2014) Stochastic variability in HIV affects viral eradication. Proc Natl. Acad. Sci. U S A 111, 13251–13252. IF 9.5 Rouzine* IM, Coffin JM, Weinberger LS (2014) 15 years later: Hard and soft selection sweeps confirm a large population number for HIV in vivo. PLOS Genetics 10, e1004179. IF 5.5 Rouzine IM, Weinberger* LS (2013) Reply to ''Coadaptive stability of interfering particles with HIV-1 when there is an evolutionary conflict''. J Virol 87: 9960. IF 4.4 Rouzine IM, Weinberger* LS (2013) Design requirements for interfering particles to maintain co-adaptive stability with HIV-1. J Virol 87: 2081-2093. IF 4.4 Rouzine* IM, Weinberger LS (2013) The quantitative theory of within-host viral evolution [review]. J Stat Mech (2013) P01009 Good BH, Rouzine IM, Balick DJ, Hallatschek O, and Desai* MM (2012) Distribution of fixed beneficial mutations and the rate of adaptation in asexual populations. Proc Natl Acad Sci U S A 109: 4950-4955 IF 9.5
Batorsky R, Kearney MF, Palmer SE, Maldarelli F, Rouzine* IM, Coffin JM (2011) Estimate of effective recombination rate and average selection coefficient for HIV in chronic infection. Proc Natl Acad Sci U S A 108: 5661- IF 9.5 Rouzine*, IM, and Coffin, JM (2010) Many-site adaptation in the presence of infrequent recombination. Theor Pop Bio 77: 189-204 Sergeev, RA, Batorsky, RE, and Rouzine*, IM (2010) Model with two types of CTL regulation and experiments on CTL dynamics. J Theor Bio 263: 369-84. Sergeev, RA, Batorsky, RE, and Rouzine*, IM (2010) Interpreting the effect of vaccination on steady state infection in animals challenged with simian immunodeficiency virus. J Theor Bio 263: 385-92. Brunet*, E, Rouzine, IM, and Wilke, CO (2008) The stochastic edge in adaptive evolution. Genetics 179: 603-620 IF 3.8 Dutta, RN, Rouzine, IM, Smith, SD, Wilke, CO, and Novella*, IS (2008) Rapid adaptive amplification of preexisting variation in an RNA virus. J Virol 82: 4354-4362. IF 4.4 Rouzine*, IM, Brunet, E, and Wilke, CO (2008) The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation. Theor Popul Biol 73: 24-46. Rouzine* IM, Coffin JM (2007) Highly fit ancestors of partly sexual populations. Theor Pop Bio 71: 239-150. ROUZINE, IGOR Gheorghiu-Svirschevski S, Rouzine* IM, Coffin JM (2007) Increasing sequence correlations limits the efficiency of recombination in a multi-site evolution model. Mol Bio Evol 254: 574- 586. IF 10.2 Rouzine* IM, Sergeev RA, Glushtsov AI (2006) Two types of cytotoxic lymphocyte regulation explain kinetics of immune response to human immunodeficiency virus. Proc Nat Acad Sci 103: 666-671 IF 9.5 Rouzine* IM, Coffin JM (2005) Evolution of HIV under selection and weak recombination. Genetics 170: 7-18 IF 3.8 Rouzine* IM, Murali-Krishna K, Ahmed R (2005) Generals die in friendly fire, or modeling immune response to HIV. J Comp Appl Math 184: 258-274. IF 1.4 Rouzine* IM, Wakeley J, Coffin JM (2003) The solitary wave of asexual evolution. Proc Nat Acad Sci 96: 587-592 IF 9.5 Rouzine* IM, McKenzie FE (2003) Link between immune response and parasite synchronization in malaria. Proc Nat Acad Sci 100: 3473-3478 IF 9.5 Rouzine* IM, Coffin JM (2001) Transition between stochastic evolution and deterministic evolution in the presence of selection: general theory and application to virology [review]. Microbio Mol Bio Rev 65: 151-185 IF 13.4 Rouzine* IM, Coffin JM (1999) Linkage disequilibrium test implies a large effective population number for HIV in vivo. Proc Nat Acad Sci 96: 10758-10763 IF 9.5 Rouzine* IM, Coffin JM (1999) Search for the mechanism of evolution in the pro gene of HIV in vivo. J Virol 73: 8167-8178 IF 4.4 Rouzine* IM, Coffin JM (1999) T cell turnover in SIV infection [comment]. Science 284: 555b IF 37.2
Theoretical physics (Note spelling of name "Rouzine" as "Ruzin” from Cyrillic original name "Рузин") Cooper* NR, Halperin BI, Hu C, Ruzin IM Statistical properties of the low-temperature conductance peak heights for Corbino disks in the quantum Hall regime. Phys Rev B 1997; 55: 4551- Cooper* NR, Halperin BI, Ruzin IM Thermoelectric response of an interacting two-dimensional electron gas in quantizing magnetic field. Phys Rev B 1997; 55: 2344- Ruzin* IM, Cooper N, Halperin BI Non-universal behavior of finite quantum Hall systems as a result of weak macroscopic inhomogeneities. Phys Rev B 1996; 53: 1558- Ruzin* I, Feng S Universal relation between longitudinal and transverse conductivities in quantum Hall effect. Phys Rev Lett 1995; 74: 154- Dykhne AM, Ruzin* IM Theory of the fractional quantum Hall effect: The two-phase model. Phys Rev B 1994; 50: 2369-2379 ROUZINE, IGOR Aleiner IL, Ruzin* IM Density of states of localized phonons in a pinned Wigner crystal. Phys Rev Lett 1994; 72: 1056-1060 Ruzin IM Hall transport in non-uniform two-dimensional conductors. Phys Rev B 1993; 47: 15727-15734 Ruzin* IM, Marianer S, Shklovskii BI Pinning of a two-dimensional Wigner crystal by charged impurities. Phys Rev B 1992: 46: 3999-4008 Ruzin IM, Chandrasekhar V, Levin EI, Glazman* LI Stochastic Coulomb blockade in a double- dot system. Phys Rev B 1992; 45: 13469-13478 Glazman LI, Ruzin IM, Shklovskii* BI Quantum transport and pinning of one-dimensional Wigner crystal. Phys Rev B 1992; 45: 8454-8463 Glazman* LI, Ruzin IM Metal-to-insulator crossover in mesoscopic wires [review]. Physica Scripta 1992; T42: 122- Ruzin IM Fine structure of hopping conductance fluctuations in finite-size semiconductors. Phys Rev B 1991; 43: 11864-11872 SD Baranovskii, EI Levin, IM Ruzin, H Fritzsche, BI Shklovskii Computer simulation of energy relaxation and recombination of nonequilibriumelectrons in a disordered system with localized electronic states International Journal of Modern Physics C 1991; 2 : 220-222 Raikh ME, Ruzin* IM Size effect in the longitudinal hopping conduction of a narrow two- dimensional channel. Phys Rev B 1990; 42: 11203-11207 Ruzin IM, Shklovskii BI Theory of hopping conductivity due to long-wavelength excitation. Sov Phys Semicond 1989; 23: 1164-1167 Orlov AO, Raikh ME, Ruzin IM, Savchenko AK Statistical properties of mesoscopic conductivity fluctuations in a short-channel GaAs field-effect transistor. Sov Phys JETP 1989; 69: 1229-1236 Baranovskii SD, Fritzsche H, Levin EI, Ruzin IM, Shklovskii BI Theory of low-temperature photoconductivity and photoluminescence in amorphous semiconductors. Sov Phys JETP 1989; 69: 773-782 Raikh ME, Ruzin IM Fluctuations of the hopping conductance of one-dimensional systems. Sov Phys JETP 1989; 68: 642-647 Orlov AO, Raikh ME, Ruzin IM, Savchenko AK Distribution function of hopping conductance fluctuations of a short GaAs field- effect transistor channel. Solid State Communic 1989; 72: 169-172 Raikh ME, Ruzin IM, Shklovskii BI Influence of localized states in a barrier on a fluctuation tunnel current flowing across a metal-semiconductor contact. Sov Phys Semicond 1988; 22: 1254-1257 Raikh ME, Ruzin IM Mesoscopic behavior of the transverse hopping conductivity of an amorphous film. Sov Phys Semicond 1988; 22: 799-805 ROUZINE, IGOR Levin EI, Ruzin IM, Shklovskii BI Transverse hopping conductivity of amorphous films in strong electric fields. Sov Phys Semicond 1988; 22: 401-408 Raikh ME, Ruzin IM Transparency fluctuations in randomly inhomogeneous barriers of finite area. Sov Phys JETP 1987; 65: 1273-1282 Tartakovskii AV, Fistul MV, Raikh ME, Ruzin IM Hopping conductivity of metal- semiconductor-metal contacts. Sov Phys Semicond 1987; 21: 370-373 Raikh ME, Ruzin IM Temperature dependence of fluctuation excess currents flowing across a metal-semiconductor contact. Sov Phys Semicond 1987; 21: 283-285 Raikh ME, Ruzin IM Mesoscopic behavior of the temperature dependence of the transverse hopping conductivity of an amorphous film. JETP Lett 1986; 43: 563-565 Gerbstein* YuM, Ruzin IM, Chudnovskii FA Fractal dimensionality of silver dendrites in the two-dimensional ionically conducting system Ag-AgI-Ag. Sov Phys Solid State 1986; 28: 1073- 1074 Raikh* ME, Ruzin IM Fluctuation mechanism of excess tunnel currents in reverse-biased p-n- junctions. Sov Phys Semicond 1985; 19: 745-750