cells Review The Glyoxalase System in Age-Related Diseases: Nutritional Intervention as Anti-Ageing Strategy Gemma Aragonès 1 , Sheldon Rowan 1,2,3 , Sarah G. Francisco 1, Elizabeth A. Whitcomb 1, Wenxin Yang 1, Giuliana Perini-Villanueva 1, Casper G. Schalkwijk 4, Allen Taylor 1,2,3,* and Eloy Bejarano 1,5,* 1 Laboratory for Nutrition and Vision Research, USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02155, USA;
[email protected] (G.A.);
[email protected] (S.R.);
[email protected] (S.G.F.);
[email protected] (E.A.W.);
[email protected] (W.Y.);
[email protected] (G.P.-V.) 2 Department of Ophthalmology, Tufts University School of Medicine, Boston, MA 02155, USA 3 Friedman School of Nutrition and Science Policy, Tufts University, Boston, MA 02155, USA 4 Department of Internal Medicine, CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands;
[email protected] 5 School of Health Sciences and Veterinary School, Universidad Cardenal Herrera-CEU, CEU Universities, Moncada, 46113 Valencia, Spain * Correspondence:
[email protected] (A.T.);
[email protected] (E.B.); Tel.: +1-617-556-3156 or +1-617-784-3199 (A.T.) Abstract: The glyoxalase system is critical for the detoxification of advanced glycation end-products (AGEs). AGEs are toxic compounds resulting from the non-enzymatic modification of biomolecules by sugars or their metabolites through a process called glycation. AGEs have adverse effects on many Citation: Aragonès, G.; Rowan, S.; tissues, playing a pathogenic role in the progression of molecular and cellular aging.