23 Dec 2004 19:46 AR AR231-PS56-10.tex AR231-PS56-10.sgm LaTeX2e(2002/01/18) P1: IKH 10.1146/annurev.psych.56.091103.070208 Annu. Rev. Psychol. 2005. 56:263–86 doi: 10.1146/annurev.psych.56.091103.070208 Copyright c 2005 by Annual Reviews. All rights reserved First published online as a Review in Advance on July 21, 2004 HUMAN DEVELOPMENT: Biological and Genetic Processes Irving I. Gottesman Department of Psychiatry and Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55454; email:
[email protected] Daniel R. Hanson Departments of Psychiatry and Psychology, University of Minnesota, Minneapolis, and Veterans Administration Hospital, Minneapolis, Minnesota 55417; email:
[email protected] KeyWords adaptive systems, endophenotypes, CNS plasticity, schizophrenia, autism ■ Abstract Adaptation is a central organizing principle throughout biology, whether we are studying species, populations, or individuals. Adaptation in biological systems occurs in response to molar and molecular environments. Thus, we would predict that genetic systems and nervous systems would be dynamic (cybernetic) in contrast to pre- vious conceptualizations with genes and brains fixed in form and function. Questions of nature versus nurture are meaningless, and we must turn to epigenetics—the way in which biology and experience work together to enhance adaptation throughout thick and thin. Defining endophenotypes—road markers that bring us closer to the biolog- ical origins of the developmental journey—facilitates our understanding of adaptive or maladaptive processes. For human behavioral disorders such as schizophrenia and autism, the inherent plasticity of the nervous system requires a systems approach to incorporate all of the myriad epigenetic factors that can influence such outcomes.