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61590 Federal Register / Vol. 82, No. 248 / Thursday, December 28, 2017 / Notices Liquid nitrated polyol and Potassium chlorate and lead sulfocyanate Water-bearing explosives having salts of trimethylolethane. explosive. oxidizing acids and nitrogen bases, sulfates, Liquid oxygen explosives. Potassium nitrate explosive mixtures. or sulfamates (cap sensitive). M Potassium nitroaminotetrazole. Water-in-oil emulsion explosive Magnesium ophorite explosives. Pyrotechnic compositions. compositions. Mannitol hexanitrate. Pyrotechnic fuses. X MDNP [methyl 4,4-dinitropentanoate]. PYX [2,6-bis(picrylamino)] 3,5- Xanthomonas hydrophilic colloid MEAN [monoethanolamine nitrate]. dinitropyridine. explosive mixture. Mercuric fulminate. R Mercury oxalate. RDX [cyclonite, hexogen, T4, cyclo-1,3,5,- Thomas E. Brandon, Mercury tartrate. trimethylene-2,4,6,-trinitramine; hexahydro- Deputy Director. Metriol trinitrate. 1,3,5-trinitro-S-triazine]. Minol-2 [40% TNT, 40% ammonium S [FR Doc. 2017–28010 Filed 12–27–17; 8:45 am] nitrate, 20% aluminum]. Safety fuse. BILLING CODE 4410–FY–P MMAN [monomethylamine nitrate]; Salts of organic amino sulfonic acid methylamine nitrate. explosive mixture. Mononitrotoluene-nitroglycerin mixture. Salutes (bulk). DEPARTMENT OF JUSTICE Monopropellants. Silver acetylide. N Silver azide. Notice of Lodging of Proposed NIBTN [nitroisobutametriol trinitrate]. Silver fulminate. Consent Decree Under the Clean Air Nitrate explosive mixtures. Silver oxalate explosive mixtures. Act Nitrate sensitized with gelled nitroparaffin. Silver styphnate. Nitrated carbohydrate explosive. Silver tartrate explosive mixtures. On December 20, 2017, the Nitrated glucoside explosive. Silver tetrazene. Department of Justice lodged a proposed Nitrated polyhydric alcohol explosives. Slurried explosive mixtures of water, consent decree with the United States Nitric acid and a nitro aromatic compound inorganic oxidizing salt, gelling agent, fuel, District Court for the District of Arizona explosive. and sensitizer (cap sensitive). in the lawsuit entitled United States v. Nitric acid and carboxylic fuel explosive. Smokeless powder. Apache Nitrogen Products, Inc., Civil Nitric acid explosive mixtures. Sodatol. Nitro aromatic explosive mixtures. Sodium amatol. Action No. 4:17–cv–00612–RCC. Nitro compounds of furane explosive Sodium azide explosive mixture. The proposed consent decree resolves mixtures. Sodium dinitro-ortho-cresolate. claims set forth in a filed complaint for Nitrocellulose explosive. Sodium nitrate explosive mixtures. civil penalties and injunctive relief Nitroderivative of urea explosive mixture. Sodium nitrate-potassium nitrate explosive against Apache Nitrogen Products, Inc. Nitrogelatin explosive. mixture. (‘‘Apache’’ or ‘‘ANPI’’) for allegedly Nitrogen trichloride. Sodium picramate. violating the Arizona State Nitrogen tri-iodide. Squibs. Implementation Plan (the ‘‘Arizona Nitroglycerine [NG, RNG, nitro, glyceryl Styphnic acid explosives. SIP’’), including the requirements for trinitrate, trinitroglycerine]. T the Prevention of Significant Nitroglycide. Tacot [tetranitro-2,3,5,6-dibenzo-1,3a,4,6a Nitroglycol [ethylene glycol dinitrate, tetrazapentalene]. Deterioration (‘‘PSD’’), as set forth in EGDN]. TATB [triaminotrinitrobenzene]. Arizona Administrative Code (‘‘AAC’’), Nitroguanidine explosives. TATP [triacetonetriperoxide]. which has been approved by the Nitronium perchlorate propellant mixtures. TEGDN [triethylene glycol dinitrate]. Environmental Protection Agency Nitroparaffins Explosive Grade and Tetranitrocarbazole. (‘‘EPA’’) under Section 110 of the Clean ammonium nitrate mixtures. Tetrazene [tetracene, tetrazine, 1(5- Air Act, 42 U.S.C. 7410, and for Nitrostarch. tetrazolyl)-4-guanyl tetrazene hydrate]. allegedly violating a federal standard of Nitro-substituted carboxylic acids. Tetrazole explosives. performance for new sources (‘‘NSPS’’) Nitrourea. Tetryl [2,4,6 tetranitro-N-methylaniline]. for nitric acid plants (40 CFR part 60, O Tetrytol. Octogen [HMX]. Thickened inorganic oxidizer salt slurried subpart G) promulgated under Section Octol [75 percent HMX, 25 percent TNT]. explosive mixture. 111 of the Clean Air Act, 42 U.S.C. Organic amine nitrates. TMETN [trimethylolethane trinitrate]. 7411. Organic nitramines. TNEF [trinitroethyl formal]. Under the decree, Apache will P TNEOC [trinitroethylorthocarbonate]. perform a computer-simulated air flow PBX [plastic bonded explosives]. TNEOF [trinitroethylorthoformate]. study for a nitric acid production unit Pellet powder. TNT [trinitrotoluene, trotyl, trilite, triton]. called ‘‘AOP–4’’ to determine, at a Penthrinite composition. Torpex. minimum, the feasibility of Selective Pentolite. Tridite. Catalytic Reduction as a control Perchlorate explosive mixtures. Trimethylol ethyl methane trinitrate Peroxide based explosive mixtures. composition. technology. The results of the study will PETN [nitropentaerythrite, pentaerythrite Trimethylolthane trinitrate-nitrocellulose. be submitted to Arizona Department of tetranitrate, pentaerythritol tetranitrate]. Trimonite. Environmental Quality (‘‘ADEQ’’), the Picramic acid and its salts. Trinitroanisole. permitting authority under the Arizona Picramide. Trinitrobenzene. SIP, and ADEQ will make a Best Picrate explosives. Trinitrobenzoic acid. Available Control Technology Picrate of potassium explosive mixtures. Trinitrocresol. determination and issue an appropriate Picratol. Trinitro-meta-cresol. permit based on its finding. Under the Picric acid (manufactured as an explosive). Trinitronaphthalene. proposed consent decree, Apache also Picryl chloride. Trinitrophenetol. Picryl fluoride. Trinitrophloroglucinol. will pay a civil penalty of $600,000. PLX [95% nitromethane, 5% Trinitroresorcinol. The publication of this notice opens ethylenediamine]. Tritonal. a period for public comment on the Polynitro aliphatic compounds. U consent decree. Comments should be Polyolpolynitrate-nitrocellulose explosive Urea nitrate. addressed to the Assistant Attorney gels. W General, Environment and Natural VerDate Sep<11>2014 18:14 Dec 27, 2017 Jkt 244001 PO 00000 Frm 00058 Fmt 4703 Sfmt 4703 E:\FR\FM\28DEN1.SGM 28DEN1 sradovich on DSK3GMQ082PROD with NOTICES Federal Register / Vol. 82, No. 248 / Thursday, December 28, 2017 / Notices 61591 Resources Division, and should refer to emissions. At the Ponca City facility in reproduction cost) payable to the United United States v. Apache Nitrogen Oklahoma and the Phenix City facility States Treasury. Products, Inc., D.J. Ref. No. 90–5–2–1– in Alabama, these pollution control Thomas Carroll, 10736. All comments must be submitted requirements included, among other no later than thirty (30) days after the Assistant Section Chief, Environmental requirements, installation of Dry Gas Enforcement Section, Environment and publication date of this notice. Scrubber or Wet Gas Scrubber (‘‘DGS’’ Natural Resources Division. Comments may be submitted either by or ‘‘WGS’’) systems designed to reduce [FR Doc. 2017–28102 Filed 12–27–17; 8:45 am] email or by mail: sulfur dioxide emissions, and Selective BILLING CODE 4410–15–P Catalytic Reduction (‘‘SCR’’) systems to To submit comments: Send them to: reduce nitrogen oxide emissions. The sulfur dioxide reduction systems are DEPARTMENT OF JUSTICE By email ....... pubcomment-ees.enrd@ also expected to result in an ancillary usdoj.gov. reduction in particulate matter Notice of Lodging of Proposed By mail ......... Assistant Attorney General, Consent Decree Under the Clean Air emissions. U.S. DOJ—ENRD, P.O. Act Box 7611, Washington, DC The parties have now agreed to 20044–7611. modify certain Consent Decree On December 22, 2017, the deadlines. The modification resolve Department of Justice lodged a proposed During the public comment period, issues regarding the feasibility of the Consent Decree with the United States the consent decree may be examined affected deadlines and resolves a District Court for the Western District of Louisiana in the lawsuit entitled United and downloaded at this Justice potential dispute between the parties States and the State of Louisiana v. Department website: https:// concerning them. The modification does www.justice.gov/enrd/consent-decrees. Orion Engineered Carbons, LLC (W.D. not change Defendant’s ultimate We will provide a paper copy of the La.), Civil Action No. 6:17–cv–01660. obligation to install and operate consent decree upon written request In this civil enforcement action under pollution controls at its facilities. and payment of reproduction costs. the federal Clean Air Act (‘‘Act’’), the Please mail your request and payment The publication of this notice opens United States and the State of Louisiana to: Consent Decree Library, U.S. DOJ— a period for public comment on the allege that Orion Engineered Carbons, ENRD, P.O. Box 7611, Washington, DC proposed modification to the Consent LLC (‘‘Defendant’’), failed to comply 20044–7611. Decree. Comments should be addressed with certain requirements of the Act Please enclose a check or money order to the Assistant Attorney General, intended to protect air quality at four for $ 15.50 (25 cents per page Environment and Natural Resources carbon black manufacturing facilities in reproduction cost) payable to the United Division, and should refer to United Franklin, Louisiana, Borger, Texas, Orange, Texas, and Belpre, Ohio. The States Treasury. States et al. v. Continental Carbon complaint seeks injunctive relief and Company, Civil Case No. 5:15–cv– Henry S. Friedman, civil penalties for violations
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    20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0
  • Endothelial Dysfunction in Heart Failure and Ischemic Heart Disease: Rationale for the Clinical Use of Mononitrates

    Endothelial Dysfunction in Heart Failure and Ischemic Heart Disease: Rationale for the Clinical Use of Mononitrates

    Heart International / Vol. 3 no. 3-4, 2007 / pp. 86-97 © Wichtig Editore, 2007 Endothelial dysfunction in heart failure and ischemic heart disease: rationale for the clinical use of mononitrates OBERDAN PARODI, RENATA DE MARIA, ELÈNA ROUBINA CNR Clinical Physiology Institute of Milan, Cardiology Department, Niguarda Cà Granda Hospital, Milan - Italy ABSTRACT: The clinical observation that heart failure can progress independently of the pa- tient’s hemodynamic status has focused interest on new, potential mechanisms underlying the progression of cardiac insufficiency. It has been shown that in both ischemic and non-ischemic heart failure, endothelial dysfunction and reduced bioavailability of NO can contribute to the process of left ventricular remodelling. The endothelial dysfunction contributes to increasing pe- ripheral vascular resistance, limiting blood flow to skeletal muscles, particularly during exercise, and compromising the regulation of pulmonary blood flow, leading to a flow-perfusion mis- match. The nitroderivates are a heterogeneous class of compounds that have in common their pharmacodynamic action, which is mediated through the production of NO. Isosorbide-2-mononitrate (IS-2-MN) and isosorbide-5-mononitrate (IS-5-MN) are the two main metabolites of isosorbide dinitrate (ISDN) and both act on the smooth muscle cells of vessel walls, causing generalized peripheral vasodilation, which is more marked in the venous system, reduced venous return to the heart and a reduction in peripheral resistance. The shorter half-life of IS-2-MN compared to that of IS-5-MN allows greater fluctuation of the blood levels of the drug; it can, therefore, be hypothesized that tolerance would develop more slowly.