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Glioblastoma Masquerading As a Parafalcine Meningioma: a Pathological Surprise!

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Glioblastoma Masquerading As a Parafalcine Meningioma: a Pathological Surprise! Published online: 2020-09-25 THIEME 668 GlioblastomaImages in Neurosciences as a Parafalcine Meningioma Varma et al. Glioblastoma Masquerading as a Parafalcine Meningioma: A Pathological Surprise! Anoop Varma1 Chittur Viswanathan Gopalakrishnan1 Nanda Kachare2 Dilip Panikar1 1Department of Neurosciences, Aster Medcity, Kochi, India Address for correspondence Chittur Viswanathan Gopalakrishnan, 2Department of Pathology, Aster Medcity, Kochi, India MS, MCh, Department of Neurosurgery, Aster Medcity, Kuttisahib Road, Cheranalloor, Kochi, India (e-mail: [email protected]). J Neurosci Rural Pract 2020;11:668–669 A 30-year-old female presented with an acute history of propensity for unilateral extension but can often be bilat- left-sided focal seizures with secondary generalization. eral and dumb-bell shaped.2 Falx meningiomas are divided Magnetic resonance imaging (MRI) of the brain (►Fig. 1) into two types: internal and external. The former origi- revealed a large tumor attached to mid one-third of the nates from the inferior sagittal sinus and the later from the falx cerebri with extension to either sides, a hetero- body of the falx.3 geneous contrast enhancement (►Fig. 1D and E) and There have been case reports in literature where glio- presence of extensive peritumoral edema. A provisional blastoma multiforme (GBMs) at different locations have diagnosis of mid one-third falx meningioma was made, mimicked a meningioma on imaging.4 Many of the times, it and the patient underwent bifrontal craniotomy and is often an intraoperative and pathological surprise. In MRI, excision of the lesion. meningiomas and GBMs can often be differentiated due to Intraoperatively, the tumor was greyish, soft to firm, vas- their characteristic appearances (►Table 1). But rarely one cular, and adherent to the falx. The pial plane between the may mimic the other causing a pathological surprise. tumor and the parenchyma was breached along with multi- In our case, on retrospective review of the images, ple pial feeders. The falx was excised along with the tumor. there were some points against a diagnosis of an extra-ax- The histopathology showed a cellular neoplasm ial lesion. The symmetrical extent of the tumor on either attached to the dural collagen (►Fig. 2A) with highly side of the falx, the extensive pial breach especially in the pleomorphic cells, hyperchromatic nuclei, intranuclear anterior cingulate, the heterogeneity on contrast pos- pseudoinclusions, and fibrillary cytoplasm with atypical sibly suggesting areas of necrosis, and nonvisualization mitosis (►Fig. 2b) and necrosis. The immunohistochemis- of a definite cerebrospinal fluid cleft surrounding the try showed strong glial fibrillary acidic protein and S-100 tumor should have raised the suspicion of a high grade in tumor cells with coexpression of epithelial membrane intrinsic tumor preoperatively. The prognosis of these antigen and retained nuclear ATRX (alpha thalassemia/ two totally diverse pathological entities is different, and mental retardation syndrome X linked gene mutation) therefore, the recognition is of utmost importance. It gene mutation. In immunohistochemistry, IDH1 (R132H) helps in surgical planning and patient counseling prior to was negative and p53 was not expressed. The Ki-67 prolif- surgery. eration index was 30%. The diagnosis of glioblastoma mul- This report highlights the importance of keeping in mind a tiforme, isocitrate dehydrogenase-wild type, World Health differential diagnosis of an alternate pathology when the MRI Organization grade IV was confirmed. features are ambiguous. Additional MRI sequences like mag- As originally proposed by Cushing, falx meningiomas netic resonance spectroscopy and MR perfusion can often are tumors arising from the falx cerebri covered by the help in clinching the diagnosis preoperatively rather than a overlying cortex.1 Falx meningiomas predominately have a histological surprise later on. DOI https://doi.org/ ©2020 Association for Helping 10.1055/s-0040-1716775 Neurosurgical Sick People ISSN 0976-3147. Glioblastoma as a Parafalcine Meningioma Varma et al. 669 Table 1 Differences between meningioma and glioblastoma based on magnetic resonance imaging Radiologic Meningioma Glioblastoma features on MRI General Well-defined Intra-axial irregular extra-axial tumor mass Extra-axial mass CSF cleft sign Thickened vs. intra-axial Broad dural base nonenhancing cortex mass Displaced with increased T2 subarachnoid vessels signal Bony hyperostosis Expansion of nearby Expand subarachnoid gyri (this is the space opposite of the white White matter matter buckling sign) buckling sign Thickening of the corpus callosum Fig. 1 T1 (A) and T2 (B) weighted axial MRI show a large heterogeneous tumor On contrast Uniform contrast Ring enhanc- encasing the falx and extending into both the cerebral hemispheres. There is administration enhancement ing contrast perilesional edema with buckling of the cortex on coronal T2W (C) image. enhancement with The attachment to the falx with its enhancement is seen in postcontrast central necrosis T1W axial (D) and coronal (E) MRI. Diffusion weighted imaging F( ) shows areas of restricted diffusion within the tumor. MRI, magnetic resonance imaging. Vasogenic Can be present Profound vasogenic edema edema Bony changes Bone hyperostosis No obvious bony and meninges show changes dural tail sign Midline crossing Can involve the Can involve the meninges causing corpus callosum contralateral and spread to the extension opposite side Local tumor Pressure effect on the Less pressure effect spread surrounding brain is in comparison to more their size Abbreviations: CSF, cerebrospinal fluid; MRI, magnetic resonance imaging. References 1 Cushing H, Eisenhardt L, Their classification, regional behavior, life history, and surgical end results. Bull Med Libr Fig. 2 Cellular neoplasm attached to dural collagen (A, H&E, ×20); Assoc1938;27(2):185 markedly pleomorphic cells with atypical mitosis (B, H&E ×400); 2 Chung SB, Kim CY, Park CK, Kim DG, Jung HW. Falx menin- immunohistochemical expression of glial fibrillary acidic protein in giomas: surgical results and lessons learned from 68 cases. J tumor cells (C); S-100, (D) epithelial membrane antigen (E) and high Korean Neurosurg Soc 2007;42(4):276–280 MIB-1 proliferation index (F). H&E, hematoxylin and eosin. 3 Yasargil MG, Microneurosurgery of CNS Tumors, IV-B. Stuttgart: Georg Thiem Verlag; 1996 134–165 4 Patel M, Nguyen HS, Doan N, Gelsomino M, Shabani S, Note Mueller W. Glioblastoma mimicking meningioma: report of The work was primarily performed at Aster Medcity, 2 cases. World Neurosurg 2016;95:624.e9–624.e13 Kochi, Kerala. 5 Smithuis R, Montanera W. The radiology assistant: systematic approach. radiologyassistant. Available at: https://radiologyas- Conflict of Interest sistant.nl/neuroradiology/brain-tumor/systematic-approach. None declared. Published 2008 Journal of Neurosciences in Rural Practice Vol. 11 No. 4/2020.
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