Spinal Meningiomas: Report of 14 Cases and Literature Review
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Vetp-42-06-Brief Communications
Veterinary Pathology Online http://vet.sagepub.com/ Primitive Neuroectodermal Tumor in the Spinal Cord of a Brahman Crossbred Calf A. Berrocal, D. L. Montgomery, J. T. Mackie and R. W. Storts Vet Pathol 2005 42: 834 DOI: 10.1354/vp.42-6-834 The online version of this article can be found at: http://vet.sagepub.com/content/42/6/834 Published by: http://www.sagepublications.com On behalf of: American College of Veterinary Pathologists, European College of Veterinary Pathologists, & the Japanese College of Veterinary Pathologists. Additional services and information for Veterinary Pathology Online can be found at: Email Alerts: http://vet.sagepub.com/cgi/alerts Subscriptions: http://vet.sagepub.com/subscriptions Reprints: http://www.sagepub.com/journalsReprints.nav Permissions: http://www.sagepub.com/journalsPermissions.nav Downloaded from vet.sagepub.com by guest on December 25, 2010 834 Brief Communications and Case Reports Vet Pathol 42:6, 2005 Vet Pathol 42:834–836 (2005) Primitive Neuroectodermal Tumor in the Spinal Cord of a Brahman Crossbred Calf A. BERROCAL,D.L.MONTGOMERY,J.T.MACKIE, AND R. W. STORTS Abstract. A variety of embryonal tumors of the central nervous system, typically malignant and occurring in young individuals, are recognized in humans and animals. This report describes an invasive subdural but predominantly extramedullary primitive neuroectodermal tumor developing at the lumbosacral junction in a 6-month-old Brahman crossbred calf. The tumor was composed of spindloid embryonal cells organized in interlacing fascicles. The cells had oval to elongate or round hyperchromic nuclei, single to double nucleoli, and scant discernible cytoplasm. Immunohistochemical staining for neuron-specific enolase, synaptophysin, and S-100 protein and formation of pseudorosettes suggested neuronal and possibly ependymal differentiation. -
Neurofibromatosis Type 2 (NF2)
International Journal of Molecular Sciences Review Neurofibromatosis Type 2 (NF2) and the Implications for Vestibular Schwannoma and Meningioma Pathogenesis Suha Bachir 1,† , Sanjit Shah 2,† , Scott Shapiro 3,†, Abigail Koehler 4, Abdelkader Mahammedi 5 , Ravi N. Samy 3, Mario Zuccarello 2, Elizabeth Schorry 1 and Soma Sengupta 4,* 1 Department of Genetics, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA; [email protected] (S.B.); [email protected] (E.S.) 2 Department of Neurosurgery, University of Cincinnati, Cincinnati, OH 45267, USA; [email protected] (S.S.); [email protected] (M.Z.) 3 Department of Otolaryngology, University of Cincinnati, Cincinnati, OH 45267, USA; [email protected] (S.S.); [email protected] (R.N.S.) 4 Department of Neurology, University of Cincinnati, Cincinnati, OH 45267, USA; [email protected] 5 Department of Radiology, University of Cincinnati, Cincinnati, OH 45267, USA; [email protected] * Correspondence: [email protected] † These authors contributed equally. Abstract: Patients diagnosed with neurofibromatosis type 2 (NF2) are extremely likely to develop meningiomas, in addition to vestibular schwannomas. Meningiomas are a common primary brain tumor; many NF2 patients suffer from multiple meningiomas. In NF2, patients have mutations in the NF2 gene, specifically with loss of function in a tumor-suppressor protein that has a number of synonymous names, including: Merlin, Neurofibromin 2, and schwannomin. Merlin is a 70 kDa protein that has 10 different isoforms. The Hippo Tumor Suppressor pathway is regulated upstream by Merlin. This pathway is critical in regulating cell proliferation and apoptosis, characteristics that are important for tumor progression. -
Risk Factors for Gliomas and Meningiomas in Males in Los Angeles County1
[CANCER RESEARCH 49, 6137-6143. November 1, 1989] Risk Factors for Gliomas and Meningiomas in Males in Los Angeles County1 Susan Preston-Martin,2 Wendy Mack, and Brian E. Henderson Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles, California 90033 ABSTRACT views with proxy respondents, we were unable to include a large proportion of otherwise eligible cases because they were deceased or Detailed job histories and information about other suspected risk were too ill or impaired to participate in an interview. The Los Angeles factors were obtained during interviews with 272 men aged 25-69 with a County Cancer Surveillance Program identified the cases (26). All primary brain tumor first diagnosed during 1980-1984 and with 272 diagnoses had been microscopically confirmed. individually matched neighbor controls. Separate analyses were con A total of 478 patients were identified. The hospital and attending ducted for the 202 glioma pairs and the 70 meningioma pairs. Meningi- physician granted us permission to contact 396 (83%) patients. We oma, but not glioma, was related to having a serious head injury 20 or were unable to locate 22 patients, 38 chose not to participate, and 60 more years before diagnosis (odds ratio (OR) = 2.3; 95% confidence were aphasie or too ill to complete the interview. We interviewed 277 interval (CI) = 1.1-5.4), and a clear dose-response effect was observed patients (74% of the 374 patients contacted about the study or 58% of relating meningioma risk to number of serious head injuries (/' for trend the initial 478 patients). -
Radiation Oncology Guidelines
National Imaging Associates, Inc.* 2021 Magellan Clinical Guidelines For Medical Necessity Review RADIATION ONCOLOGY GUIDELINES Effective January 1, 2021 – December 31, 2021 *National Imaging Associates, Inc. (NIA) is a subsidiary of Magellan Healthcare, Inc. Copyright © 2019-2020 National Imaging Associates, Inc., All Rights Reserved Guidelines for Clinical Review Determination Preamble Magellan is committed to the philosophy of supporting safe and effective treatment for patients. The medical necessity criteria that follow are guidelines for the provision of diagnostic imaging. These criteria are designed to guide both providers and reviewers to the most appropriate diagnostic tests based on a patient’s unique circumstances. In all cases, clinical judgment consistent with the standards of good medical practice will be used when applying the guidelines. Determinations are made based on both the guideline and clinical information provided at the time of the request. It is expected that medical necessity decisions may change as new evidence-based information is provided or based on unique aspects of the patient’s condition. The treating clinician has final authority and responsibility for treatment decisions regarding the care of the patient. 2021 Magellan Clinical Guidelines-Radiation Oncology 2 Guideline Development Process These medical necessity criteria were developed by Magellan Healthcare for the purpose of making clinical review determinations for requests for therapies and diagnostic procedures. The developers of the criteria sets included representatives from the disciplines of radiology, internal medicine, nursing, cardiology, and other specialty groups. Magellan’s guidelines are reviewed yearly and modified when necessary following a literature search of pertinent and established clinical guidelines and accepted diagnostic imaging practices. -
Spinal Meningiomas: a Review
nal of S ur pi o n J e Galgano et al., J Spine 2014, 3:1 Journal of Spine DOI: 10.4172/2165-7939.1000157 ISSN: 2165-7939 Review Rrticle Open Access Spinal Meningiomas: A Review Michael A Galgano, Timothy Beutler, Aaron Brooking and Eric M Deshaies* Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, NY, USA Abstract Meningiomas of the spinal axis have been identified from C1 to as distal as the sacrum. Their clinical presentation varies greatly based on their location. Meningiomas situated in the atlanto-axial region may present similarly to some meningiomas of the craniocervical junction, while some of the more distal spinal axis meningiomas are discovered as a result of chronic back pain. Surgical resection remains the mainstay of treatment, although advancements in radiosurgery have led to increased utilization as a primary or adjuvant therapy. Angiography also plays a critical role in surgical planning and may be utilized for preoperative embolization of hypervascular meningiomas. Keywords: Meningioma; Neurosurgery; Radiosurgery; Angiography favorable and biological outcome [11]. They also found that either a lack of estrogen and progesterone receptors, or the presence of estrogen Introduction receptors in meningiomas, correlated with a more aggressive clinical Spinal meningiomas are tumors originating from arachnoid cap behavior, progression, and recurrence. Hsu and Hedley Whyte also cells most commonly situated in the intradural extramedullary region found that the presence of progesterone receptors, even in a small [1,2]. They represent a high proportion of all spinal cord tumors. Spinal subgroup of tumor cells, indicated a more favorable prognostic value meningiomas tend to predominate in the thoracic region, although for meningiomas [12]. -
Primary Spinal Astrocytomas: a Literature Review
Open Access Review Article DOI: 10.7759/cureus.5247 Primary Spinal Astrocytomas: A Literature Review John Ogunlade 1 , James G. Wiginton IV 1 , Christopher Elia 1 , Tiffany Odell 2 , Sanjay C. Rao 3 1. Neurosurgery, Riverside University Health System Medical Center, Moreno Valley, USA 2. Neurosurgery, Desert Regional Medical Center, Palm Springs, USA 3. Neurosurgery, Kaiser Permanente - Fontana Medical Center, Fontana, USA Corresponding author: John Ogunlade, [email protected] Abstract Primary spinal astrocytoma is a subtype of glioma, the most common spinal cord tumor found in the intradural intramedullary compartment. Spinal astrocytomas account for 6-8% of all spinal cord tumors and are primarily low grade (World Health Organization grade I (WHO I) or WHO II). They are seen in both the adult and pediatric population with the most common presenting symptoms being back pain, sensory dysfunction, or motor dysfunction. Magnetic Resonance Imaging (MRI) with and without gadolinium is the imaging of choice, which usually reveals a hypointense T1 weighted and hyperintense T2 weighted lesion with a heterogeneous pattern of contrast enhancement. Further imaging which may aid in surgical planning includes computerized tomography, diffusion tensor imaging, and tractography. Median survival in spinal cord astrocytomas ranges widely. The factors most significantly associated with poor prognosis and shorter median survival are older age at initial diagnosis, higher grade lesion based on histology, and extent of resection. The mainstay of treatment for primary spinal cord astrocytomas is surgical resection, with the goal of preservation of neurologic function, guided by intraoperative neuromonitoring. Adjunctive radiation has been shown beneficial and may increase overall survival. -
Surgical Results of the Resection of Spinal Meningioma with the Inner Layer of Dura More Than 10 Years After Surgery
www.nature.com/scientificreports OPEN Surgical results of the resection of spinal meningioma with the inner layer of dura more than 10 years after surgery Hiroyuki Tominaga1*, Ichiro Kawamura1, Kosei Ijiri2, Kazunori Yone1 & Noboru Taniguchi1 Most spinal meningiomas arise from the thoracic dura in middle-aged and elderly women. Simpson grade 1 resection is recommended to avoid recurrence. For ventral and ventrolateral tumors, reconstruction after total dural resection is difcult, and spinal fuid leakage is likely. To overcome this concern, Saito et al. developed the technique of resecting the tumor with the inner dural layer, preserving the outer dural layer. Although meningioma rarely recurs, the recurrence period is approximately 8 years postoperatively. No studies have evaluated long-term (> 10-year) outcomes of the Saito method. Here, we report 10 cases of the Saito method with > 10-year follow-up and compare outcomes with those of other standard approaches. Twenty-nine pathology-confrmed meningioma patients underwent surgery in our department, ten with the Saito method. We investigated resection method (dura mater treatment), pathological type, and recurrence and compared pre- and postoperative clinical fndings. The median follow-up was 132 months. Recurrence occurred after Simpson grades 3 and 4 resection. Simpson grades 1, 2, and the Saito method resulted in no recurrence. Neurological symptoms improved in all patients at fnal follow-up. This is the frst report of long-term outcomes of the Saito method. The method achieved good neurological improvement with no recurrence in > 10-year follow-up. Spinal cord meningioma is an intradural, extramedullary tumor that occurs most frequently at the thoracic level in middle-aged and elderly women. -
The WHO Grade I Collagen-Forming Meningioma Produces Angiogenic Substances
ANTICANCER RESEARCH 36: 941-950 (2016) The WHO Grade I Collagen-forming Meningioma Produces Angiogenic Substances. A New Meningioma Entity JOHANNES HAYBAECK1*, ELISABETH SMOLLE1,2*, BERNADETTE SCHÖKLER3 and REINHOLD KLEINERT1 1Department of Neuropathology, Institute of Pathology, Medical University Graz, Graz, Austria; 2Department of Internal Medicine, Division of Pulmonology, Medical University Graz, Graz, Austria; 3Department of Neurosurgery, Medical University Graz, Graz, Austria Abstract. Background: Meningiomas arise from arachnoid seems to be most appropriate. Conclusion: The "WHO Grade cap cells, the so-called meningiothelial cells. They account I collagen-forming meningioma" reported herein produces for 20-36% of all primary intracranial tumours, and arise collagen and angiogenic substances. To the best of our with an annual incidence of 1.8-13 per 100,000 knowledge, no such entity has been reported on in previous individuals/year. According to their histopathological features literature. We propose this collagen-producing meningioma meningiomas are classified either as grade I (meningiothelial, as a novel WHO grade I meningioma sub-type. fibrous/fibroblastic, transitional/mixed, psammomatous, angiomatous, microcystic, secretory and the Meningiomas arise from arachnoid cap cells, the so-called lympholasmacyterich sub-type), grade II (atypical and clear- meningiothelial cells (1-5). They account for 20-36% of all cell sub-type) or grade III (malignant or anaplastic primary intracranial tumours, and arise with an annual phenotype). Case Report: A 62-year-old female patient incidence of 1.8-13 per 100,000 individuals/year (1-5). presented to the hospital because of progressive obliviousness Meningiomas are the second most common central nervous and concentration difficulties. In the magnetic resonance system neoplasms in adults (6-9). -
A Case of Mushroom‑Shaped Anaplastic Oligodendroglioma Resembling Meningioma and Arteriovenous Malformation: Inadequacies of Diagnostic Imaging
EXPERIMENTAL AND THERAPEUTIC MEDICINE 10: 1499-1502, 2015 A case of mushroom‑shaped anaplastic oligodendroglioma resembling meningioma and arteriovenous malformation: Inadequacies of diagnostic imaging YAOLING LIU1,2, KANG YANG1, XU SUN1, XINYU LI1, MINGHAI WEI1, XIANG'EN SHI2, NINGWEI CHE1 and JIAN YIN1 1Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044; 2Department of Neurosurgery, Affiliated Fuxing Hospital, The Capital University of Medical Sciences, Beijing 100038, P.R. China Received December 29, 2014; Accepted June 29, 2015 DOI: 10.3892/etm.2015.2676 Abstract. Magnetic resonance imaging (MRI) is the most tomas (WHO IV) (2). The median survival times of patients widely discussed and clinically employed method for the with WHO II and WHO III oligodendrogliomas are 9.8 and differential diagnosis of oligodendrogliomas; however, 3.9 years, respectively (1,2), and 6.3 and 2.8 years, respec- MRI occasionally produces unclear results that can hinder tively, if mixed with astrocytes (3,4). Surgical excision and a definitive oligodendroglioma diagnosis. The present study postoperative adjuvant radiotherapy is the traditional therapy describes the case of a 34-year-old man that suffered from for oligodendroglioma; however, studies have observed that, headache and right upper‑extremity weakness for 2 months. among intracranial tumors, anaplastic oligodendrogliomas Based on the presurgical evaluation, it was suggested that the are particularly sensitive to chemotherapy, and the prognosis patient had a World Health Organization (WHO) grade II-II of patients treated with chemotherapy is more favorable glioma, meningioma or arteriovenous malformation (AVM), than that of patients treated with radiotherapy (5‑7). -
Brain Invasion in Meningioma—A Prognostic Potential Worth Exploring
cancers Review Brain Invasion in Meningioma—A Prognostic Potential Worth Exploring Felix Behling 1,2,* , Johann-Martin Hempel 2,3 and Jens Schittenhelm 2,4 1 Department of Neurosurgery, University Hospital Tübingen, Eberhard-Karls-University Tübingen, 72076 Tübingen, Germany 2 Center for CNS Tumors, Comprehensive Cancer Center Tübingen-Stuttgart, University Hospital Tübingen, Eberhard-Karls-University Tübingen, 72076 Tübingen, Germany; [email protected] (J.-M.H.); [email protected] (J.S.) 3 Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Eberhard-Karls-University Tübingen, 72076 Tübingen, Germany 4 Department of Neuropathology, University Hospital Tübingen, Eberhard-Karls-University Tübingen, 72076 Tübingen, Germany * Correspondence: [email protected] Simple Summary: Meningiomas are benign tumors of the meninges and represent the most common primary brain tumor. Most tumors can be cured by surgical excision or stabilized by radiation therapy. However, recurrent cases are difficult to treat and alternatives to surgery and radiation are lacking. Therefore, a reliable prognostic marker is important for early identification of patients at risk. The presence of infiltrative growth of meningioma cells into central nervous system tissue has been identified as a negative prognostic factor and was therefore included in the latest WHO classification for CNS tumors. Since then, the clinical impact of CNS invasion has been questioned by different retrospective studies and its removal from the WHO classification has been suggested. Citation: Behling, F.; Hempel, J.-M.; There may be several reasons for the emergence of conflicting results on this matter, which are Schittenhelm, J. Brain Invasion in discussed in this review together with the potential and future perspectives of the role of CNS Meningioma—A Prognostic Potential invasion in meningiomas. -
Meningioma ACKNOWLEDGEMENTS
AMERICAN BRAIN TUMOR ASSOCIATION Meningioma ACKNOWLEDGEMENTS ABOUT THE AMERICAN BRAIN TUMOR ASSOCIATION Meningioma Founded in 1973, the American Brain Tumor Association (ABTA) was the first national nonprofit advocacy organization dedicated solely to brain tumor research. For nearly 45 years, the ABTA has been providing comprehensive resources that support the complex needs of brain tumor patients and caregivers, as well as the critical funding of research in the pursuit of breakthroughs in brain tumor diagnosis, treatment and care. To learn more about the ABTA, visit www.abta.org. We gratefully acknowledge Santosh Kesari, MD, PhD, FANA, FAAN chair of department of translational neuro- oncology and neurotherapeutics, and Marlon Saria, MSN, RN, AOCNS®, FAAN clinical nurse specialist, John Wayne Cancer Institute at Providence Saint John’s Health Center, Santa Monica, CA; and Albert Lai, MD, PhD, assistant clinical professor, Adult Brain Tumors, UCLA Neuro-Oncology Program, for their review of this edition of this publication. This publication is not intended as a substitute for professional medical advice and does not provide advice on treatments or conditions for individual patients. All health and treatment decisions must be made in consultation with your physician(s), utilizing your specific medical information. Inclusion in this publication is not a recommendation of any product, treatment, physician or hospital. COPYRIGHT © 2017 ABTA REPRODUCTION WITHOUT PRIOR WRITTEN PERMISSION IS PROHIBITED AMERICAN BRAIN TUMOR ASSOCIATION Meningioma INTRODUCTION Although meningiomas are considered a type of primary brain tumor, they do not grow from brain tissue itself, but instead arise from the meninges, three thin layers of tissue covering the brain and spinal cord. -
Relationship Between Tumor Location, Size, and WHO Grade in Meningioma
NEUROSURGICAL FOCUS Neurosurg Focus 44 (4):E4, 2018 Relationship between tumor location, size, and WHO grade in meningioma *Stephen T. Magill, MD, PhD, Jacob S. Young, MD, Ricky Chae, Manish K. Aghi, MD, PhD, Philip V. Theodosopoulos, MD, and Michael W. McDermott, MD Department of Neurological Surgery, University of California, San Francisco, California OBJECTIVE Prior studies have investigated preoperative risk factors for meningioma; however, no association has been shown between meningioma tumor size and tumor grade. The objective of this study was to investigate the rela- tionship between tumor size and grade in a large single-center study of patients undergoing meningioma resection. METHODS A retrospective chart review of patients undergoing meningioma resection at the University of California, San Francisco, between 1985 and 2015 was performed. Patients with incomplete information, spinal meningiomas, mul- tiple meningiomas, or WHO grade III meningiomas were excluded. The largest tumor dimension was used as a surrogate for tumor size. Univariate and multivariate logistic regression models were used to investigate the relationship between tumor grade and tumor size. A recursive partitioning analysis was performed to identify groups at higher risk for atypical (WHO grade II) meningioma. RESULTS Of the 1113 patients identified, 905 (81%) had a WHO grade I tumor and in 208 (19%) the tumors were WHO grade II. The median largest tumor dimension was 3.6 cm (range 0.2–13 cm). Tumors were distributed as follows: skull base (n = 573, 51%), convexity/falx/parasagittal (n = 431, 39%), and other (n = 109, 10%). On univariate regression, larger tumor size (p < 0.001), convexity/falx/parasagittal location (p < 0.001), and male sex (p < 0.001) were significant predictors of WHO grade II pathology.