This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version. A link to any extended data will be provided when the final version is posted online. Research Articles: Cellular/Molecular Restoring Tip60 HAT/HDAC2 balance in the neurodegenerative brain relieves epigenetic transcriptional repression and reinstates cognition Priyalakshmi Panikker, Song-Jun Xu, Haolin Zhang, Jessica Sarthi, Mariah Beaver, Avni Sheth, Sunya Akhter and Felice Elefant Department of Biology, Drexel University, Philadelphia, PA 19104, USA DOI: 10.1523/JNEUROSCI.2840-17.2018 Received: 28 September 2017 Revised: 26 March 2018 Accepted: 6 April 2018 Published: 13 April 2018 AUTHOR CONTRIBUTION: P.P., and F.E. designed the research; P.P., S.X., H.Z., J.S., M.B., A.S., and S.A conducted the experiments; P.P., S.X., H.Z., J.S., and F.E. analyzed the data; P.P. and F.E. wrote the paper. Conflict of Interest: The authors declare no competing financial interests. The authors thank the Cell Imaging Center (CIC) at Drexel University for their imaging facilities and to Dr. Denise Garcia for generously contributing antibodies for human hippocampal immunohistochemistry. This work was supported by NIH grant R01HD057939 to F.E. Corresponding Author: Felice Elefant, Ph.D., 3245 Chestnut Street, PISB 312, Department of Biology, Drexel University, Philadelphia, PA 19104, USA.; Email:
[email protected], FAX: 215-895-1273 Cite as: J. Neurosci ; 10.1523/JNEUROSCI.2840-17.2018 Alerts: Sign up at www.jneurosci.org/cgi/alerts to receive customized email alerts when the fully formatted version of this article is published.