Review of Some Euphorbiaceae Plants in Usada Taru Pramana and Its Pharmacological Activities
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Journal of Pharmaceutical Science and Application Volume 3, Issue 1, Page 1-12, June 2021 E-ISSN : 2301-7708 REVIEW OF SOME EUPHORBIACEAE PLANTS IN USADA TARU PRAMANA AND ITS PHARMACOLOGICAL ACTIVITIES I Gede Bangkit Adi Sentosa1, I Kadek Suardiana1, A.A Gede Rai Yadnya Putra1* 1Department of Pharmacy, Faculty of Mathematics and Science, Udayana University Corresponding author email: [email protected] ABSTRACT Background: World Health Organization (WHO) states that up to 65% of the world's population uses traditional medicines. Indonesia is one of the countries where most people still use traditional medicine, especially in Bali. The traditional Balinese plant-based medical system that has existed for a long time and is still inherited today is Usada Taru Pramana. One of the many plants found in Usada Taru Pramana is the Euphorbiaceae. Objective: This work aims to review some of the Euphorbiaceae plants written in Usada Taru Pramana, which have a variety of potential pharmacological activities. Method: This article review using a primary and secondary data sources. Results: Some parts of the Euphorbiaceae plants in Usada Taru Pramana contain important phytochemical constituents such as phenols, alkaloids, flavonoids, saponins, tannins and essential oils. Some of the potential pharmacological activities that have been tested are anti-inflammatory, analgesic, and antibacterial. Conclusion: The Euphorbiaceae plants in Usada Taru Pramana have a variety of phytochemical constituents and correlates with its pharmacological activities. Further research needs to be conducted to explore other Euphorbiaceae plants species in Usada Taru Pramana to find compounds and other pharmacological activities to deal with various diseases in the community. Keywords: Usada Taru Pramana, Euphorbiaceae, Phytochemical Constituents, Pharmacological Activities. INTRODUCTION World Health Organization (WHO) and compiled into a text of medical states that up to 65% of the world's knowledge, how to concoct medicine, how population uses traditional medicines and to treat or treat traditionally or traditional medicines from natural ingredients Balinese medicine[2]. The word Usada (Kemenkes RI 2007)[1]. Indonesia is one of comes from the word ausadhi (Sanskrit), the countries where most people still use which means plants that contain medicinal traditional medicine and have a variety of properties. There are various types of traditional medical systems based on Lontar Usada, one of which is Lontar natural ingredients, especially in Bali. The Usada Taru Pramana. Taru pramana is use of plant-based medicines is a popular derived from the word “taru”, meaning approach to health care in Indonesia, plant and “premana” means strength or especially Bali. The traditional Balinese efficacy. Usada Taru Pramana is a plant-based medical system that has papyrus that tells the plants to come to existed for a long time and is still inherited Mpu Kuturan to express their respective today is Usada Bali. Usada is a term for properties that can be used as medicines[3]. the Balinese system of treatment written on Usada Taru Pramana contains a papyrus with Balinese language and script description of the method of treatment 1 DOI : https://doi.org/10.24843/JPSA.2021.v03.i01.p01 Sentosa, et al. Volume 3, Issue 1, Page 1-12, June 2021 (usada) in the form of dialogue in the convince the public that the plants disclosure of how to treat it[4]. Parts of contained in Usada Taru Pramana do have plants that can be used in medicine are pharmacological activities and are from the leaves, flowers, fruits, seeds, beneficial to health. bark, sap, roots, rhizomes and all parts of the plant. METHODS Usada Taru Pramana consists of This primary data source was obtained approximately 182 plants with diverse from the derivation of Usada Taru properties and uses. These plants come Pramana papyrus by Putra (1999)[8]. This from various family, including Liliaceae, process of finding secondary data sources Fabaceae, Moraceae, Lauraceae, is obtained by searching on google, google Asteraceae, Piperaceae, Zingiberaceae, scholar, and NCBI with the keywords Euphorbiaceae, and others. One of the “phytochemical constituents of Acalypha many plants found in Usada Taru hispida, Antidesma bunius, Ricinus Pramana is the Euphorbiaceae. communis, Jatropha curcas, Pedilanthus Euphorbiaceae is a large family of tithymaloides, Aleurites moluccana, and flowering plants with about 300 genera and Sauropus androgynus“ and 8.000 species. This allows the “pharmacological activities of Acalypha Euphorbiaceae plants to be the largest hispida, Antidesma bunius, Ricinus plant with many species. The implication communis, Jatropha curcas, Pedilanthus is that there is a higher chance that some tithymaloides, Aleurites moluccana, and species of plants will have medicinal Sauropus androgynus“. Secondary data properties. Most Euphorbiaceae plants are sources used are journals that have been herbaceous, but several other species are published for the past ten years. The use of found as shrubs or trees in the tropics[5,6]. data over the last ten years is applied of no The distribution of Euphorbiaceae plants last ten years of data is supported. spread in the territory of Indonesia, Malaysia, and America. Some RESULTS Euphorbiaceae plants are written in Usada The result obtained from the primary Taru Pramana such as cat tail (Acalypha data source in the form of derivation hispida), buni (Antidesma bunius), jarak Usada Taru Pramana is several (Ricinus communis), candlenut (Aleuritus Euphorbiaceae plants and the plant's parts mollucana), and others[7,8]. Traditionally, used. The phytochemical constituents and the Euphorbiaceae plants are used to treat pharmacological activities were obtained eye pain, dizziness, plaque, thrush, sore from the various data source in this review. throat, and pain throughout the body. The result obtained from the primary data The Euphorbiaceae plants have been source is listed in Table 1. widely used as traditional medicine by various methods of treatment. However, DISCUSSION scientific evidence is needed to ensure that 1. Acalypha hispida the Euphorbiaceae plants are scientifically In Usada Taru Pramana, the Acalypha proven to have healing activity. In this hispida plant or ekor kucing is known as a review, we have summarized some of the crop of white langurs and has efficacy as Euphorbiaceae plants in Usada Taru an eye remedy. Ekor kucing plus onions Pramana along with some phytochemical and fennel are then ground, filtered, and compounds and pharmacological activities. precipitated as an eye medicine. The existence of scientific evidence from several studies is expected to further 2 DOI : https://doi.org/10.24843/JPSA.2021.v03.i01.p01 Sentosa, et al. Volume 3, Issue 1, Page 1-12, June 2021 Table 1. Some Euphorbiaceae Plants in Usada Taru Pramana and Its Phytochemical Constituents and Pharmacological Activities Phytochemical Pharmacological No Species Parts Constituents Activities Phenol compounds, flavonoids, glycosides, steroids, saponins, Antibacterial, 1 Acalypha hispida Leaves[7,8] hydroxyantraquinones, gallic Antioxidant[12,13,14,15] acid, corilagin, and triterpenoids[11] Polyphenols, terpenoids, Leaves, glucoside, saponins, tannins, Fruits, Antiinflammation, 2 Antidesma bunius biflavonoids, anthocyanins, Roots, Antibacterial[18,19] luteolin, rutin, resveratrol, Barks[7,8] and quercetin[16,17] Antiinflammation, Leaves, Steroids, saponins, alkaloids, 3 Ricinus communis Antinociceptive, Roots[7,8] flavonoids, and glycosides[20] Analgesic[21,22,23] Antiinflammation, Roots, Phenols, tannins, free amino 4 Jatropha curcas Wound Healing, Latex[7,8] acids and phytic acid[24] Antibacterial[25,26] Alkaloids, flavonoids, Pedilanthus terpenoids, phenols, tannins, Antiinflammation, 5 Leaves[7,8] tithymaloides saponins, glycosides, sterols, Antinociceptive[28,29] and amino acids[27] Alkaloids, polyphenols, Aleurites Seeds, flavonoids, coumarin, Antibacterial, 6 moluccana Bark[7,8] tannins, steroids, and Antinociceptive[31,32,33] triterpenoids[30] Sterols, resins, tannins, saponins, alkaloids, Antiinflammation, Sauropus flavonoids, terpenoids, 7 Leaves[7,8] Antibacterial, Anti- androgynus glycosides, phenols, cardiac obesity[35,36,37,38] glycosides, and acidic compounds[34] The eye disease in question is gallic acid, corilagin, triterpenoids, conjunctivitis caused by a bacterial flavonoids such as quercetin and infection. In general, the bacteria that kaempferol derivatives[11]. The leaves of cause conjunctivitis are Gram-positive and Acalypha hispida are reported to contain Gram-negative bacteria. Examples of several phytochemical compounds and Gram-positive bacteria are Staphylococcus have antibacterial activity. Acalypha aureus, Staphylococcus epidermidis, hispida leaf extract contains carbohydrates, Streptococcus pneumonia, and cardiac glycosides, anthraquinone Streptococcus viridians and examples of glycosides, tannins, alkaloids, steroids, Gram-negative bacteria are Escherichia saponins, and flavonoids. coli, Pesudomonas aeruginosa, Klebsiella The methanol extract of Acalypha pneumonia, Serratia marcescens, Proteus hispida leaves inhibits more bacteria than sp., andEnterobacterus sp.[9,10]. other extracts of Acalypha hispida solvents Phytochemical screening of water and such as ethanol, chloroform, and water. In methanol extracts of plant leaves showed testing the antibacterial activity by the the presence of phenol compounds, Kirby-Bauer agar diffusion method, the flavonoids, glycosides, steroids, saponins,