An Overview of American Ginseng Through the Lens of Healing, Conservation and Trade Margaret Wulfsberg Lawrence University
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Clinical Effects of Korean Ginseng, Korean Red Ginseng, Chinese
2006. Vol. 27. No. 4. 198-208 Korean Journal of Oriental Medicine Original Article Clinical Effects of Korean Ginseng, Korean Red Ginseng, Chinese Ginseng, and American Ginseng on Blood Pressure in Mild Hypertensive Subjects Dong-Jun Choi, Ki-Ho Cho 1) , Woo-Sang Jung 1) , Seong-Uk Park 2) Chang-Ho Han, Won-Chul Lee Department of Oriental Internal Medicine, International Hospital Dong-Guk University Goyang-city, Gyeonggi-do, Korea Department of Cardiovascular and Neurologic Diseases (Stroke Center) College of Oriental Medicine, Kyung-Hee University, Seoul, Korea 1) Stroke & Neurological Disorders Center, East-West Neo Medical Center Kyung-Hee University, Seoul, Korea 2) Background : Ginseng has traditionally been used in oriental countries to recover vital energy from Qi deficiency, and has shown various biomedical effects in the scientific literature. Recent reports suggest that ginseng could regulate blood pressure (BP), but much controversy still remains. Therefore, we intended to assess the anti-hypertensive effect of several ginseng types frequently used in clinics. We also investigated the anti-hypertensive effect on Koreans and Chinese, and by the body type according to Sasang Constitution Medicine (SCM). Methods : The study subjects were recruited from mildly hypertensive patients who exhibited pre-hypertension (120/80 to 139/89 mmHg) and stage I hypertension (140/90 to 159/99 mmHg) in Korea and China. After assigning the subjects into a Korean, a Chinese, a red, and an American ginseng group by randomization, we prescribed ginseng at a dose of 4.5 g per day for 4 weeks. To assess the anti-hypertensive effect, we compared the mean of systolic and diastolic BP between before and after ginseng medication using a 24-hour ambulatory blood pressure monitor (24 hr ABPM). -
Allozyme Variation in American Ginseng, Panax Quinquefolius L (Araliaceae): Implications for Management of Wild and Cultivated Populations
W&M ScholarWorks Dissertations, Theses, and Masters Projects Theses, Dissertations, & Master Projects 2001 Allozyme Variation in American Ginseng, Panax quinquefolius L (Araliaceae): Implications for Management of Wild and Cultivated Populations Holly Jean Grubbs College of William & Mary - Arts & Sciences Follow this and additional works at: https://scholarworks.wm.edu/etd Part of the Plant Sciences Commons Recommended Citation Grubbs, Holly Jean, "Allozyme Variation in American Ginseng, Panax quinquefolius L (Araliaceae): Implications for Management of Wild and Cultivated Populations" (2001). Dissertations, Theses, and Masters Projects. Paper 1539626306. https://dx.doi.org/doi:10.21220/s2-zyrf-5943 This Thesis is brought to you for free and open access by the Theses, Dissertations, & Master Projects at W&M ScholarWorks. It has been accepted for inclusion in Dissertations, Theses, and Masters Projects by an authorized administrator of W&M ScholarWorks. For more information, please contact [email protected]. ALLOZYME VARIATION IN AMERICAN GINSENG, Panax quinquefolius L. (Araliaceae): IMPLICATIONS FOR MANAGEMENT OF WILD AND CULTIVATED POPULATIONS A Thesis Presented to The Faculty of the Department of Biology The College of William and Mary In Partial Fulfillment Of the Requirements for the Degree of Master of Arts By Holly Jean Grubbs 2001 APPROVAL SHEET This thesis is presented in partial fulfillment of The requirement for the degree of Master of Arts lly J. Grubbs Approved April, 2001 C Martha A. Case, Ph.D. c&OOna H . 'frf&TZ, Donna M. E. Ware, Ph.D. ’juuml <'IUQIU l Stewart A. Ware, Ph.D. DEDICATION This work is dedicated to my grandparents, J. Owen Pence, Verda Pence, and Norma Whitbeck, who each, in a unique way, taught me a love and curiosity for the natural world and persistence in seeking beauty and truth. -
Chemical Authentication of Botanical Ingredients: a Review of Commercial Herbal Products
MINI REVIEW published: 15 April 2021 doi: 10.3389/fphar.2021.666850 Chemical Authentication of Botanical Ingredients: A Review of Commercial Herbal Products Mihael Cristin Ichim 1* and Anthony Booker 2,3* 1“Stejarul” Research Centre for Biological Sciences, National Institute of Research and Development for Biological Sciences, Piatra Neamt, Romania, 2Research Centre for Optimal Health, School of Life Sciences, College of Liberal Arts and Sciences, University of Westminster, London, United Kingdom, 3Pharmacognosy and Phytotherapy, UCL School of Pharmacy, London, United Kingdom Chemical methods are the most important and widely used traditional plant identification techniques recommended by national and international pharmacopoeias. We have reviewed the successful use of different chemical methods for the botanical authentication of 2,386 commercial herbal products, sold in 37 countries spread over six continents. The majority of the analyzed products were reported to be authentic (73%) but more than a quarter proved to be adulterated (27%). At a national level, the number of products and the adulteration proportions varied very widely. Yet, the adulteration reported for the four countries, from which more than 100 commercial products were purchased Edited by: and their botanical ingredients chemically authenticated, was 37% (United Kingdom), 31% Marcello Locatelli, University of Studies G. d’Annunzio (Italy), 27% (United States), and 21% (China). Simple or hyphenated chemical analytical Chieti and Pescara, Italy techniques have identified the total absence of labeled botanical ingredients, substitution Reviewed by: with closely related or unrelated species, the use of biological filler material, and the hidden Santhosh Kumar J. Urumarudappa, Chulalongkorn University, Thailand presence of regulated, forbidden or allergenic species. -
Two Common Medicinal Plants of Pakistan and Their Pharmacological Activities: a Mini Review
Crimson Publishers Mini Review Wings to the Research Two Common Medicinal Plants of Pakistan And Their Pharmacological Activities: A Mini Review Hina Salahuddin1, Ejaz Aziz2, Riffat Batool3* 1Department of Zoology, University of Okara, Okara, Pakistan 2 ISSN: 2637-7802 Department of Botany, GDC Khanpur, Haripur, Pakistan 3University Institute of Biochemistry and Biotechnology, PMAS-UAAR Rawalpindi, Pakistan Abstract Lots of today’s synthetic medicines are created from the number of plants. A great deal of work has been done in the field of allopathic and herbal medicine, as reported by number of publications describing therapeuticphytoconstituents purposes. in previousWorldwide years nearly as oneanti-tumor fourth of drugs,the prescribed contraceptives drugs aredrugs, originated anti-inflammatory, from plants, antioxidant drugs etc. A plant contains numerous chemical compounds, which work for different species worldwide are reported. Pakistan is a rich country in terms of vegetation of medicinal and aromatic121 active plants. chemical Medicial constituents plants inof Pakistanplants are are currently used to intreat use. different About 85,000 ailments, valuable like hepatic medicinal diseases, plant cardiac problems, common disorders like fever, cough, diarrhea, cold etc. with less or no side effects. Purpose of present study is to deliver information on the therapeutic potentials of two common medicinal *Corresponding author: Riffat Batool, plants (Cannabis sativa, Chenopodium album) commonly used in traditional medicines in Pakistan. Both University Institute of Biochemistry and of these plants possess different biological activities and various therapeutic uses. Biotechnology, PMAS-UAAR Rawalpindi, Keywords: Pakistan; Medicinal plants; Phytochemistry; Cannabis sativa; Chenopodium album Pakistan Submission: Introduction Published: September 19, 2019 Lots of today’s synthetic medicines are created from the number of plants [1]. -
Panax Ginseng
Last updated on December 22, 2020 Cognitive Vitality Reports® are reports written by neuroscientists at the Alzheimer’s Drug Discovery Foundation (ADDF). These scientific reports include analysis of drugs, drugs-in- development, drug targets, supplements, nutraceuticals, food/drink, non-pharmacologic interventions, and risk factors. Neuroscientists evaluate the potential benefit (or harm) for brain health, as well as for age-related health concerns that can affect brain health (e.g., cardiovascular diseases, cancers, diabetes/metabolic syndrome). In addition, these reports include evaluation of safety data, from clinical trials if available, and from preclinical models. Panax Ginseng Evidence Summary Some studies have shown that ginseng improves cognitive functions and decreases mortality and cancer risk in humans; safe when taken alone, but some drug interactions are known. Neuroprotective Benefit: Numerous studies have reported cognitive benefit with ginseng in healthy people as well as in dementia patients, but the evidence remains inconclusive due to the lack of large, long-term well-designed trials. Aging and related health concerns: Ginseng intake is associated with lower risks for mortality and cancers; also, some benefits seen in Asian people with ischemic heart disease, diabetes, hypertension, hypercholesteremia, and fatigue. Safety: Numerous meta-analyses have reported that ginseng is generally safe when taken alone; however, ginseng interacts with several medications, and high doses may be associated with insomnia, tachyarrhythmias, hypertension, nervousness, and others. 1 Last updated on December 22, 2020 Availability: OTC. In clinical Dose: 200-400 mg/day Chemical formula: e.g., C42H72O14 trials, a standardized ginseng have been tested for (Ginsenoside Rg1); C54H92O23 extract called G115 is often cognitive benefit; higher (Ginsenoside Rb1) used. -
Panax Ginseng) from Different Regions
molecules Article Analysis of Ginsenoside Content (Panax ginseng) from Different Regions Wei Chen 1,2,3 , Prabhu Balan 2,3 and David G Popovich 1,* 1 School of Food and Advanced Technology, Massey University, Palmerston North 4442, New Zealand; [email protected] 2 Riddet Institute, Massey University, Palmerston North 4442, New Zealand; [email protected] 3 Alpha-Massey Natural Nutraceutical Research Centre, Massey University, Palmerston North 4442, New Zealand * Correspondence: [email protected]; Tel.: +64-63569099 Academic Editor: Vincenzo De Feo Received: 3 September 2019; Accepted: 25 September 2019; Published: 26 September 2019 Abstract: Recently Panax ginseng has been grown as a secondary crop under a pine tree canopy in New Zealand (NZ). The aim of the study is to compare the average content of ginsenosides from NZ-grown ginseng and its original native locations (China and Korea) grown ginseng. Ten batches of NZ-grown ginseng were extracted using 70% methanol and analyzed using LC-MS/MS. The average content of ginsenosides from China and Korea grown ginseng were obtained by collecting data from 30 and 17 publications featuring China and Korea grown ginseng, respectively. The average content of total ginsenosides in NZ-grown ginseng was 40.06 3.21 mg/g (n = 14), which showed significantly ± (p < 0.05) higher concentration than that of China grown ginseng (16.48 1.24 mg/g, n = 113) and ± Korea grown ginseng (21.05 1.57 mg/g, n = 106). For the individual ginsenosides, except for the ± ginsenosides Rb2, Rc, and Rd, ginsenosides Rb1, Re, Rf, and Rg1 from NZ-grown ginseng were 2.22, 2.91, 1.65, and 1.27 times higher than that of ginseng grown in China, respectively. -
Araliaceae – Ginseng Family
ARALIACEAE – GINSENG FAMILY Plant: some herbs (perennial), woody vines, shrubs and trees Stem: usually pithy Root: sometimes with rhizomes Leaves: simple or palmately compound but rarely 2’s or 3’s, often thickened and large, mostly alternate (rarely opposite or whorled); usually with stipules that forms a stem sheath; often with star-shaped hairs Flowers: mostly perfect or unisexual (monoecious or dioecious), regular (actinomorphic); flowers very small, mostly in umbels; sepals 5, often forming small teeth or none, mostly 5(-10) petals; mostly 5(-10) stamens; ovary inferior, 2-5 (10) fused carpels Fruit: berry or drupe, oily Other: mostly tropical and subtropical, a few oranamentals; similar to Apiaceae; Dicotyledons Group Genera: 70+ genera; locally Aralia (spikenard), Hedera (English Ivy), Oplopanax, Panax (ginseng) WARNING – family descriptions are only a layman’s guide and should not be used as definitive Araliaceae (Ginseng Family) – 5 (mostly) sepals and petals (often 5-lobed), often in umbels or compound umbels; leaves simple or more often compound; fruit a berry or drupe Examples of common genera Devil's Walkingstick [Hercules’ Club] Wild Sarsaparilla Aralia spinosa L. Aralia nudicaulis L. Devil's Club [Devil’s Walking Stick; Alaskan Ginseng] Oplopanax horridus (Sm.) Miq. English Ivy Hedera helix L. (Introduced) Dwarf Ginseng Panax trifolius L. ARALIACEAE – GINSENG FAMILY Wild Sarsaparilla; Aralia nudicaulis L. Devil's Walkingstick [Hercules’ Club]; Aralia spinosa L. English Ivy; Hedera helix L. (Introduced) Devil's Club [Devil’s -
From Medicinal Plant Raw Material to Herbal Remedies 271
Provisional chapter Chapter 16 From Medicinal Plant Raw Material to FromHerbal Medicinal Remedies Plant Raw Material to Herbal Remedies SofijaSofija M. M. Djordjevic Djordjevic Additional information is available at the end of the chapter Additional information is available at the end of the chapter http://dx.doi.org/10.5772/66618 Abstract The use of medicinal plants is old as the existence of mankind. According to World Health Organization (WHO) data, about 80% of world population are using products based on medicinal herbs. Phytotherapy is based on the use of herbal drugs and medicinal prod- ucts for the purpose of prevention and treatment. Rational phytotherapy is a modern concept of herbal medicines using, which are made of standardized herbal extracts. The quality of each final product is guaranteed by the use of raw materials of a standard qual- ity, defined process of production, and validated equipment. Quality control of herbal drugs and herbal isolates (tinctures, extracts, and essential oils) is done according to the requirements of Pharmacopoeia and other relevant regulations. The scope of phy- topreparation quality control depends on its pharmaceutical form. The formulation of a new phytopreparation is a process that has strictly defined phases: from analysis of liter- ature and market, through defining recipes, validation of the production process, quality control of a final product to the preparation of technological and registration documents. The aim of this chapter is to present the process of herbal preparations production from selecting plant raw materials to herbal remedies (on the examples of making tea, tea mix- ture, drops, gels, and capsules). -
American Ginseng (Panax Quinquefolius)
American ginseng (Panax quinquefolius) • American ginseng is a wild perennial Situation plant that has become very rare in Canada—the harvest of wild American When American ginseng was first discovered growing in ginseng is considered unsustainable. North America in 1715, it set off a lucrative trade business and rapidly became the second most important Canadian • American ginseng is an endangered export after fur. The roots of ginseng had been used species and is protected by law. for centuries in traditional Asian medicine, and it was − It is protected on federal lands under in high demand. Ginseng is still used by many people the Species at Risk Act. today in the practice of traditional medicine. − The harvest, trade and cultivation Unfortunately, this wild perennial plant has become of wild, wild-simulated and very rare in Canada, and the harvest of wild American woods-grown American ginseng ginseng is now considered unsustainable. Very few viable is prohibited under Ontario’s populations remain in Canada; even low levels of harvest Endangered Species Act, 2007. and poaching pose a real threat to its survival because of − In Quebec, under the Loi sur les its slow growth and low rate of reproduction in the wild. espèces menacées ou vulnérables, American ginseng plants are long‑lived but can take three harvest or trade of wild American to eight years to reach maturity and begin flowering. ginseng is prohibited. In Canada, wild American ginseng is found only in • The export of wild American ginseng southern Ontario and Quebec. Over‑harvesting, poaching is prohibited from Canada—only and habitat destruction have led to its being listed as cultivated American ginseng can be nationally endangered (Species at Risk Act), provincially legally traded in Canada. -
Panax Ginseng
Cognitive Vitality Reports® are reports written by neuroscientists at the Alzheimer’s Drug Discovery Foundation (ADDF). These scientific reports include analysis of drugs, drugs-in- development, drug targets, supplements, nutraceuticals, food/drink, non-pharmacologic interventions, and risk factors. Neuroscientists evaluate the potential benefit (or harm) for brain health, as well as for age-related health concerns that can affect brain health (e.g., cardiovascular diseases, cancers, diabetes/metabolic syndrome). In addition, these reports include evaluation of safety data, from clinical trials if available, and from preclinical models. Panax ginseng Evidence Summary Some studies have shown that ginseng improves cognitive functions and decreases mortality and cancer risk in humans; safe when taken alone, but some drug interactions are known. Neuroprotective Benefit: Numerous studies have reported cognitive benefit with ginseng in healthy people as well as in dementia patients, but the evidence remains inconclusive due to the lack of large, long-term well-designed trials. Aging and related health concerns: Ginseng intake is associated with lower risks for mortality and cancers; also, some benefits seen in Asian people with ischemic heart disease, diabetes, hypertension, hypercholesteremia, and fatigue. Safety: Numerous meta-analyses have reported that ginseng is generally safe when taken alone; however, ginseng interacts with several medications. 1 Availability: OTC. No Dose: 200-400 mg/day Chemical formula: e.g., C42H72O14 pharmaceutical -
Global Ginseng Research
인삼문화 Journal of Ginseng Culture 2 (2020) 1-8 Research Article Global ginseng research Phuoc Long Nguyen*, Hoang Anh Nguyen**, Jeong Hill Park*** 초 록 지금까지 Web of Science의 core collection에 나타난 인삼 관련 연구논문의 수를 분석하 였다. 인삼논문이 처음 나타난 1905년부터 2019년까지 전세계에서 총 8,090편의 SCI(E) 논 문이 출판된 것으로 나타났다. 그중 최근 24년, 즉, 1996년부터 2019년까지의 논문이 7,385 편이었다. 1980년 18편에 불과했던 인삼 논문이 1990년에는 53편, 2000년에는 97편, 2010 년에는 369편, 2019년에는 678편으로 비약적으로 증가하였다. Web of Science의 core col- lection에 수재된 전체 학술논문에서 인삼 논문이 차지하는 비중도 1970년 0.0008%, 1980 년 0.0044%, 1990년 0.101%, 2000년 0.0141%에서 2019년에는 0.0422%로 비약적으로 증가 하였다. 지난 24년간 출판된 인삼 연구논문 중 원보(노트 포함)는 7,099편, 리뷰는 286편이었다. 총 78개국 3,286개 기관에서 연구가 이루어졌으며, 1,274개 학술잡지에 논문이 수재되었다. 전체 논문 중 중국에서 연구된 논문이 40.3%로 가장 높았고, 대한민국에서 연구된 논문 이 34.7%로 한국과 중국의 연구가 전체의 75%를 차지하였다. 그 다음은 미국(6.0%), 일본 (4.1%), 캐나다(2.9%) 순이었다. 2013년까지는 한국에서 연구된 논문이 가장 많았으나 2014 년부터 중국에서 연구된 논문의 수가 더 많아졌다. 지난 24년간 인삼은 전세계에서 가장 많이 연구된 약용식물로 인삼 다음으로는 차(6,499편), 마늘(3,641편), 은행(2,590편), 생강 (1,945편) 순이었다. 주제어: 인삼, 연구논문의 수, web of science Abstract We conducted a comprehensive analysis of research papers on ginseng to provide an overview of global ginseng research. The qualitative and quantitative interpretation was carried out using collected data of Panax species and six other herbal plants from the Web of ScienceTM Core Collection. -
American Ginseng & Endangered Species Panax Quinquefolius L
Natural Heritage American Ginseng & Endangered Species Panax quinquefolius L. Program www.mass.gov/nhesp State Status: Special Concern Federal Status: None Massachusetts Division of Fisheries & Wildlife DESCRIPTION: American Ginseng is a perennial herb long known for the reputed medicinal and aphrodisiac properties of its aromatic root. The genus name Panax reflects the reputed value of various species of ginseng as a cure-all or panacea. The unbranched stem is 20 - 40 cm (8 - 15 in.) high and is topped by a single whorl of 1 to 5 palmately compound leaves. Usually, three compound leaves are produced, each with five serrate (pointed and toothed) leaflets. The tiny flowers are produced in a single, ball-like cluster in the fork where the leaf stalks meet the stem. The five-petalled flowers are white or greenish-yellow and are scented like Lily-of- the-valley. They appear from late June to mid-July. The fruits, bright red drupes one cm. (0.4 in.) in diameter, are easily seen in the fall. American Ginseng plants less than three years old usually bear no fruit, and it takes 18 to 22 months between the time when the ripe fruit drops to the ground and the time the seed will germinate. SIMILAR SPECIES: Virginia Creeper (Parthenocissus quinquefolia), like American Ginseng, has five palmate leaflets, but it is usually a climbing or sprawling vine with tendrils. Also, the leaves of Virginia Creeper are alternately arranged, unlike the whorled leaves of American Ginseng. Wild Sarsaparilla (Aralia nudicaulis) is also similar in appearance to American Ginseng. In contrast to American Ginseng, its five leaflets are Oklahoma.