SERIES PERSONALISED MEDICINE From systems biology to P4 medicine: applications in respiratory medicine Guillaume Noell1,2, Rosa Faner1,2 and Alvar Agustí1,2,3 Number 4 in the Series “Personalised medicine in respiratory diseases” Edited by Renaud Louis and Nicolas Roche Affiliations: 1Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. 2CIBER Enfermedades Respiratorias (CIBERES), Barcelona, Spain. 3Respiratory Institute, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain. Correspondence: Alvar Agustí, Respiratory Institute, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. E-mail:
[email protected] @ERSpublications Systems biology and network medicine have the potential to transform medical research and practice http://ow.ly/r3jR30hf35x Cite this article as: Noell G, Faner R, Agustí A. From systems biology to P4 medicine: applications in respiratory medicine. Eur Respir Rev 2018; 27: 170110 [https://doi.org/10.1183/16000617.0110-2017]. ABSTRACT Human health and disease are emergent properties of a complex, nonlinear, dynamic multilevel biological system: the human body. Systems biology is a comprehensive research strategy that has the potential to understand these emergent properties holistically. It stems from advancements in medical diagnostics, “omics” data and bioinformatic computing power. It paves the way forward towards “P4 medicine” (predictive, preventive, personalised and participatory), which seeks to better intervene preventively to preserve health or therapeutically to cure