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Update on Oesophageal Atresia-Tracheoesophageal Fistula UPDATE on OESOPHAGEAL ATRESIA- TRACHEOESOPHAGEAL FISTULA UPDATE ON OESOPHAGEAL ATRESIA- TRACHEOESOPHAGEAL FISTULA EDITED BY : Usha Krishnan and Christophe Faure PUBLISHED IN : Frontiers in Pediatrics Frontiers Copyright Statement About Frontiers © Copyright 2007-2017 Frontiers Media SA. All rights reserved. Frontiers is more than just an open-access publisher of scholarly articles: it is a pioneering All content included on this site, approach to the world of academia, radically improving the way scholarly research such as text, graphics, logos, button icons, images, video/audio clips, is managed. The grand vision of Frontiers is a world where all people have an equal downloads, data compilations and software, is the property of or is opportunity to seek, share and generate knowledge. 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Find out more on how to host your own Frontiers ISSN 1664-8714 Research Topic or contribute to one as an author by contacting the Frontiers Editorial ISBN 978-2-88945-304-7 DOI 10.3389/978-2-88945-304-7 Office:[email protected] Frontiers in Pediatrics 1 October 2017 | Update on Oesophageal Atresia-Tracheoesophageal Fistula UPDATE ON OESOPHAGEAL ATRESIA- TRACHEOESOPHAGEAL FISTULA Topic Editors: Usha Krishnan, Sydney Children’s Hospital, University of New South Wales, Australia Christophe Faure, Université de Montréal, Centre Hospitalier Universitaire Sainte-Justine, Canada Oesophageal atresia-tracheoesophageal fistula (OA-TOF) is a congenital digestive malformation. With improvements in surgical techniques and perioperative care, survival rates now exceed 90% and OA-TOF is no more just a neonatal surgical problem, and the focus has now shifted from mortality to morbidity with focus on long-term survival and quality of life issues. The primary complications experienced by these patients include gastroesophageal reflux, peptic and eosinophilic esophagitis, anastomotic stricture, esophageal dysmotility, abnormal gastric function, feeding difficulties and respiratory disorders including tracheomalacia and “cyanotic spells”. Concerns in adults include oesophageal adenocarcinoma and epidermoid carcinoma which have been recently reported. This highlights the need for careful multidisciplinary follow up not only High resolution oesophageal manometry pattern in in childhood but also after transition Oesophageal Atresia-Tracheoesophageal Fistula. Image: to adulthood. Data regarding long- Christophe Faure. term outcomes and follow-ups are limited for patients following OA- TOF repair. The determination of the risk factors for the complicated evolution following OA-TOF repair may positively impact long-term prognoses. This e-book contains review articles and position paper on all aspects of management of this condition. The material Frontiers in Pediatrics 2 October 2017 | Update on Oesophageal Atresia-Tracheoesophageal Fistula presented in the following articles is primarily based on the presentations by world experts during the recent Fourth International Conference on Oesophageal Atresia held in Sydney in 2016. Citation: Krishnan, U., Faure, C., eds. (2017). Update on Oesophageal Atresia-Tracheoesophageal Fistula. Lausanne: Frontiers Media. doi: 10.3389/978-2-88945-304-7 Frontiers in Pediatrics 3 October 2017 | Update on Oesophageal Atresia-Tracheoesophageal Fistula Table of Contents CHAPTER 1: EDITORIAL 06 Editorial: Oesophageal Atresia-Tracheoesophageal Fistula Usha Krishnan and Christophe Faure CHAPTER 2: INTERNATIONAL REGISTRY 09 Importance of an International Registry for and Collaborative Research on Esophageal Atresia Frédéric Gottrand, Delphine Ley, Laurent Michaud and Rony Sfeir CHAPTER 3: LONG GAP ESOPHAGEAL ATRESIA 13 Position Paper of INoEA Working Group on Long-Gap Esophageal Atresia: For Better Care David C. van der Zee, Pietro Bagolan, Christophe Faure, Frederic Gottrand, Russell Jennings, Jean-Martin Laberge, Marcela Hernan Martinez Ferro, Benoît Parmentier, Rony Sfeir and Warwick Teague CHAPTER 4: GASTROESOPHAGEAL REFLUX Impedance Testing 16 Impedance Testing in Esophageal Atresia Patients Maheen Hassan and Hayat Mousa Fundoplication 22 Fundoplication in Patients with Esophageal Atresia: Patient Selection, Indications, and Outcomes Risto J. Rintala CHAPTER 5: ESOPHAGEAL FUNCTION Dysmotility Characterisation of Dysmotility 27 Dysmotility in Esophageal Atresia: Pathophysiology, Characterization, and Treatment Christophe Faure and Franziska Righini Grunder Investigation of Dysmotility 33 The Potential Benefits of Applying Recent Advances in Esophageal Motility Testing in Patients with Esophageal Atresia Nathalie Rommel, Maissa Rayyan, Charlotte Scheerens and Taher Omari Frontiers in Pediatrics 4 October 2017 | Update on Oesophageal Atresia-Tracheoesophageal Fistula CHAPTER 6: GASTRIC FUNCTION 40 Gastric Function in Children with Oesophageal Atresia and Tracheoesophageal Fistula Gilles Duvoisin and Usha Krishnan CHAPTER 7: ANASTOMOTIC STRICTURES 48 Anastomotic Strictures after Esophageal Atresia Repair: Incidence, Investigations, and Management, Including Treatment of Refractory and Recurrent Strictures Renato Tambucci, Giulia Angelino, Paola De Angelis, Filippo Torroni, Tamara Caldaro, Valerio Balassone, Anna Chiara Contini, Erminia Romeo, Francesca Rea, Simona Faraci, Giovanni Federici di Abriola and Luigi Dall’Oglio CHAPTER 8: FEEDING PROBLEMS 62 Feeding Problems and Their Underlying Mechanisms in the Esophageal Atresia–Tracheoesophageal Fistula Patient Lisa Mahoney and Rachel Rosen CHAPTER 9: EXTRA-ESOPHAGEAL COMPLICATIONS Aspiration Risk 71 Aspiration Risk and Respiratory Complications in Patients with Esophageal Atresia Thomas Kovesi Cyanotic Spells 78 The Management of Cyanotic Spells in Children with Oesophageal Atresia Mathieu Bergeron, Aliza P. Cohen and Robin T. Cotton CHAPTER 10: FUTURE DIRECTIONS 85 Update on Foregut Molecular Embryology and Role of Regenerative Medicine Therapies Silvia Perin, Conor J. McCann, Osvaldo Borrelli, Paolo De Coppi and Nikhil Thapar Frontiers in Pediatrics 5 October 2017 | Update on Oesophageal Atresia-Tracheoesophageal Fistula EDITORIAL published: 31 August 2017 doi: 10.3389/fped.2017.00190 Editorial: Oesophageal Atresia-Tracheoesophageal Fistula Usha Krishnan1,2* and Christophe
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