DOCSLIB.ORG

Randlabspring 2018 Newsletter Spring 2018 Newsletter

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Randlabspring 2018 Newsletter Spring 2018 Newsletter RANDLABSPRING 2018 NEWSLETTER SPRING 2018 NEWSLETTER ALTRENOGEST has been used in performance fillies and mares for over 20 years. So why is its use now being restricted? In no mood to work. Mares behaving badly. Randlab’s Global Technical Veterinarian, Dr Michael Robinson, presents the facts behind the current Altrenogest debate KEY POINTS Altrenogest is still able to be used in performance mares that are: · Racing in NSW (oral only and not within one clear day of racing). · Not competing in official Equestrian Australia/FEI events · Non-competition fillies and mares · Pleasure/recreational fillies and mares · Breeding mares Under the Australian Rules of Racing and FEI Clean Sport For Horses Regulations, it is illegal to use Altrenogest in male horses. Altrenogest injection delivers a peak concentration that is approximately seven times that achieved by daily oral administration of Altrenogest. All current formulations of Altrenogest contain a low level of background impurities including trenbolone and trendione. The higher peaks obtained with Altrenogest injection may also result in higher peaks of any impurities and may lead to a positive swab. Altrenogest injections maintain plasma levels above those of daily oral Altrenogest for a period of 5-7 days following injection. This may be compounded by repeated weekly injections which results in plasma levels that are sustained for longer. Nothing has changed with the oral formulations of Altrenogest as there was one clear day between administration and racing (ie Thursday for over 20 years. However, its use has recently been brought administration for a Saturday race). into question by racing authorities. So why the change? Racing NSW continues to allow the use of oral Altrenogest up until one clear As most veterinarians are now aware, Racing Victoria issued a notice on 19 day from racing. June warning Victorian racehorse trainers and veterinarians against the use of Altrenogest. This unanticipated warning applied to both the oral and injectable On 26 July Equestrian Australia also circulated a notice to participants in equestrian formulations of the drug. sports advising that “Injectable Altrenogest should not be used and that oral Altrenogest products should also not be administered close to or during an event”. The warning was issued in response to the detection of the prohibited substances Table 1 shows a summary of all current (01 October 2018) Altrenogest warnings. trenbolone and trendione (both anabolic androgenic steroids) from two racing mares in Victoria in September 2017 and January 2018. The source of these positive swabs had been traced to the injectable form of Altrenogest (specifically AUTHORITY WARNING Ceva’s Readyserve Injection). Racing Victoria Do not use oral or injectable Altrenogest Oral Altrenogest may be used up until one clear day Nothing has changed in the ORAL Altrenogest formulations over the Racing NSW past 20 years. Trenbolone and trendione have always been in there at of racing low background levels that would have no therapeutic effect. For the past Racing Qld Do not use oral or injectable Altrenogest 20 years, oral Altrenogest has been routinely used in the racing industry Oral Altrenogest may be used up until one clear day Racing WA and other competitive equestrian sports and has not presented a doping of racing problem to regulatory officials. Racing SA Do not use oral or injectable Altrenogest Anabolic steroids are prohibited substances under the Australian Rule of Racing Racing Tas Do not use oral or injectable Altrenogest (AR.178H) which states that; “A horse must not, in any manner, at any time, be administered an anabolic androgenic steroid”. This ban applies from birth until Harness Racing Authority Do not use oral or injectable Altrenogest the end of the horse’s racing career. Penalties for offenders are harsh with a Do not use injectable Altrenogest. mandatory disqualification of the horse from racing for a minimum period of 12 Equestrian Australia / FEI Oral Altrenogest should not be used close to or months and a minimum of a two-year disqualification for those incriminated in during an event. the administration of the anabolic. Oral Altrenogest may be used up until one clear day NZTR & HRNZ of racing at the listed label dose rate. Racing NSW subsequently (22 June 2018) issued a similar notice against the use of injectable Altrenogest. However, the Racing NSW warning differed from TABLE 1: Current Altrenogest Warnings as of 01 October 2018. that of Racing Victoria in that oral Altrenogest could continue to be used as long AUSTRALIAN OWNED AUSTRALIAN MADE www.randlab.com.au 7/85 Alfred Road, Chipping Norton NSW 2170 Australia • Phone: (61-2) 9728 3505 • Fax: (61-2) 9728 4352 • Email: [email protected] www.randlab.com.au QUALITYAUSTRALIAN • SERVICEOWNED • VALUEAUSTRALIAN • CARE MADE 1 ) $,.:/!D)(/1A()")(5;;"+:)14)"%%).5++0#3)L?[)C0230;&0+)>?FOM)6%3+0#170(3)A"+#-#7(8) 6%3+0#170(3)-()#13).1#<0+30$)31)0-3/0+)I+0#&1%1#0)1+)I+0#$-1#0)-#)<-<18) ) ) Q#K0.3"&%0)A00^%:)6%3+0#170(3)/"()&00#)"<"-%"&%0)"()"#)6SE,6R+07-(30+0$)2+1$5.3)-#)65(3+"%-")41+) $"E#&!DF!G15/0A!":A/07B/-A!H,5030B-!I,-!76!=D!*/4A/8./5!<=DJK! "22+1J-;"30%:)3A1):0"+(8)I/0)+0.1;;0#$0$)$1(0)+"30)41+)-#K0.3"&%0)6%3+0#170(3)-()?8_;7`^78))I/0) "L$M(%N$O!F!!!!!!!!!!H"%'N')! +0.1;;0#$0$)$"-%:)$1(0)+"30)41+)1+"%)6%3+0#170(3)-()?8?aa);7`^78))))) %,930B!P39A753,F)*1)#13)5(0)1+"%)1+)-#K0.3"&%0)6%3+0#170(3) ) %,930B!'*HF)9+"%)6%3+0#170(3);":)&0)5(0$)52)5#3-%)1#0).%0"+)$":)14)+".-#7) I/5()3/0)$1(0)14)-#K0.3"&%0)6%3+0#170(3)-()"22+1J-;"30%:)(0<0#)3-;0()3/"3)14)3/0)$"-%:)1+"%)$1(08))) I/-()-()"%(1)+04%0.30$)-#)3/0)2%"(;")6%3+0#170(3)%0<0%(=)A/-./)20"^)A-3/-#)3/0)4-+(3)F>)/15+()"#$) %,930B!Q:2F)*1)#13)5(0)1+"%)1+)-#K0.3"&%0)6%3+0#170(3) +0;"-#)/-7/)41+)"22+1J-;"30%:)aO)/15+()"430+)"$;-#-(3+"3-1#)L(00)\-75+0)>M8) %,930B!H"F)9+"%)6%3+0#170(3);":)&0)5(0$)52)5#3-%)1#0).%0"+)$":)14)+".-#7) ) %,930B!*"F)*1)#13)5(0)1+"%)1+)-#K0.3"&%0)RANDLAB6%3+0#170(3) ) TN)L%&!<F!V/,0!4:,-8,!9709/0A5,A370-!67::7@30B!@//W:>!30X/9A370-!,02!2,3:>!75,:!27-30B!@3A+! %,930B!$,-F)*1)#13)5(0)1+"%)1+)-#K0.3"&%0)6%3+0#170(3) ":A5/07B/-A!30!7;,53/9A783-/2!8,5/-?! M,50/--!%,930B!"1A+753A>F))*1)#13)5(0)1+"%)1+)-#K0.3"&%0)6%3+0#170(3) &R1/-A53,0!"1-A5,:3,!S!T&NF)*1)#13)5(0)-#K0.3"&%0)6%3+0#170(38))) So))))))))9+"%) what6%3+0#170(3)(/15%$)#13)&0)5(0$).%1(0)31)1+)$5+-#7)"#)0<0#38 has changed? ) Altrenogest'UF!!DDD))W1)25&%-(/0$)-#41+;"3-1# is chemically very ) closely related to both trenbolone (see) Figure 1) and trendione. In fact, an alternative chemical name for! Altrenogest is allyltrenbolone. Trendione is a prohormone with *(!HMO!$M&!GM"')&C) virtually6%3+0#170(3 no)-()./0;-."%%:) activity<0+:).%1(0%:)+0%"30$)31)&13/)3+0#&1%1#0)L(00) per se. However Trendione can\-75+0)FM)"#$)3 be converted+0#$-1#08))Q#) to Trenbolone4".3=)"#)"%30+#"3-<0)./0;-."%)#";0)41+) in the body. 6%3+0#170(3)-()"%%:%3+0#&1%1#08) ) TN)L%&!DFAltrenogest!!$+/!,0257B/039!,0,.7:39!-A/5732-!$5/0.7:70/!,02!$5/02370/!,5/!9+/839,::>!5/:,A/2!A7! is not converted to either trenbolone or trendione in ":A5/07B/-Avivo. ?!!":A5/07B/-A!3-!07A!8/A,.7:3-/2!A7!/3A+/5!$5/0.7:70/!75!$5/02370/!!"#$!$%?! ! ) $5/,A8/0A!"!Y!":A5/07B/-A!30X/9A370!I=?Z8BSWBK!,02!$5/,A8/0A!E!Y!(5,:!":A5/07B/-A!I=?=[[8BSWBK8))))))) FIGURE)*"3").15+30(:)14) 2: Mean*+)H":;0)b1: plasma)>?FO =)P/"+%0()C35+3)c#-<0+(-3:8concentrations following) weekly injections and) daily oral dosing with Altrenogest in ovariectomised mares. TreatmentI/0(0)/-7/0+)2%"(;")%0<0%() A = AltrenogestA-3/)3/0)-#K0.3"&%0)41+;5%"3-1#) injection (0.3mg/kg)"+0)"%(1)2+1&"&%:)+04%0.30$)-#)")/-7/0+) and Treatment B = .1#.0#3+"3-1#)14)3/0)-;25+-3-0()-#)3/0)&%11$8)))Q4)3/0)/1+(0)A0+0)30(30$)A-3/-#)aO)/15+()14) Oral"$;-#-(3+"3-1#)14) Altrenogest3/0)6%3+0#170 (0.044mg/kg).(3)-#K0.3-1#=)-3)-()%-^0%:)3/"3)")/-7/0+)%0<0%)14)-;25+-3-0( Presumably the pharmacokinetics)A15%$)&0) of any$030.30$= chemically)"#$)3/-();": similar)&0)0#157/)31 impurities)+0(5%3)-#)")21(-3-<0)(A"&8 will mimic )the Altrenogest data. Data courtesy) of Jaymie Loy 2018, Charles Sturt University. )) ) ) c#$0+)3/0)2+0<"-%-#7)65(3+"%-"#)!5%0()14)!".-#7=)"$;-#-(3+"3-1#)14)6%3+0#170(3)-#K0.3-1#)-#)4-%%-0()"#$) ) These;"+0()52)5#3-% higher)1#0 ).%0"+)$":plasma)14)+".-#7 levels)A"()20+;-330$8 with the ) injectable formulation are also I/-()./0;-."%)(-;-%"+-3:);0"#()3/"3)-#);1(3)L-4)#13)"%%M)(";2%0()14)6%3+0#170(3)3/0+0)A-%%)&0)")(;"%%) )) FIGURE";15#3)14)-;25+-3-0()-#.%5$-#7)3+0#&1%1#0)"#$)3+0#$-1#08))I:2-."%%: 1: The androgenic anabolic steroids trenbolone)3/0(0)"+0)2+0(0#3)-#)%0<0%() and trendione probably!".-#7)E-.31+-")-().5++0#3%:)(3-%%)-#<0(3-7"3-#7) reflected in a higher 3/0).-+.5;(3"#.0()"+15#$)3/0)E-.31+-"#)21(-3-<0)concentration of the impurities in the are&0%1A)?8?[ closely])"#$= chemically)"()(5./=)"3)%0<0% related()3/"3)"+0) &13/)(5&3/0+"2053-.to Altrenogest.=)-#.1#(0B50#3-"%) Altrenogest"#$)&0%1A)#1+;"%) is not blood.3+0#&1%1#0`3+0#$-1#0 If the horse)(A"&(8)) were6%3/157/)3/0)(15+.0)-() tested within 48%-^0%:)31)&0 hours)3/0) of!0"$:(0+<0) administration6%3+0#170(3 of) the metabolised$030.3-1#)%-;-3(8 ))to) either trenbolone or trendione in vivo.
Load more

Recommended publications
  • New Rules Pertaining to the Banning of Anabolic Steroids in the Western Australian Harness Racing Industry to Be Introduced 1St September 2014
    NEW RULES PERTAINING TO THE BANNING OF ANABOLIC STEROIDS IN THE WESTERN AUSTRALIAN HARNESS RACING INDUSTRY TO BE INTRODUCED 1ST SEPTEMBER 2014 Notice is hereby given that the Board of Racing and Wagering WA have resolved that the RWWA Rules of Harness Racing 2004 be amended. In accordance with section 45 (1) (b) of the Racing and Wagering Western Australia Act 2003 the Board of Racing and Wagering WA on the 10th April 2014 resolved that these amendments be adopted accordingly into the RWWA Rules of Harness Racing. The Harness Racing Board had advised of these amendments and the RWWA Board has determined that these amendments will come into effect on 1st September 2014. The details of the relevant rules pertaining to this ban of anabolic steroids for reference can be found following this advice. There are many implications arising from the introduction of these rules, and to assist trainers and veterinarians to comply with the new rules the following explanatory statement has been prepared. Which steroids are banned under these rules? The new rules ban the use of "anabolic androgenic steroids" in Standardbred horses at any time from birth until retirement. "Anabolic androgenic steroids" include those that are currently registered in Australia by the APVMA for use in horses, such as boldenone, ethylestrenol (in Nitrotain), methandriol, nandrolone, stanozolol and testosterone. Exogenous anabolic androgenic steroids that are banned also include but are not limited to those listed in the WADA prohibited list, such as 1-androstenediol; 1-androstenedione;
    [Show full text]
  • Expression of Recombinant Human Androgen Receptor and Its Use for Screening Methods
    Institut für Physiologie FML Weihenstephan Technische Universität München Expression of recombinant human androgen receptor and its use for screening methods Ellinor Rose Sigrid Bauer Vollständiger Abdruck der von der Fakultät Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt der Technischen Universität München zur Erlangung des akademischen Grades eines Doktors der Naturwissenschaften genehmigten Dissertation. Vorsitzender: Univ.-Prof. Dr. B. Hock Prüfer der Dissertation: Univ.-Prof. Dr. H. H. D. Meyer Univ.-Prof. Dr. H. Sauerwein (Rheinische Friedrich-Wilhelms-Universität Bonn) Die Dissertation wurde am 31.10.2002 bei der Technischen Universität München eingereicht und durch die Fakultät Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt am 03.12.2002 angenommen. Introduction Content 1. INTRODUCTION ..................................................................................................................................... 5 1.1. ENDOCRINE DISRUPTERS 5 1.2. ANDROGENS AND ANTIANDROGENS 7 1.2.1. DEFINITIONS 7 1.2.2. MODE OF ACTION 8 1.3. STRUCTURES OF ENDOCRINE DISRUPTERS 10 1.4. STRATEGIES FOR MONITORING ANDROGEN ACTIVE SUBSTANCES 13 1.4.1. IN VIVO METHODS 13 1.4.2. IN VITRO METHODS 15 1.5. OBJEKTIVE OF THE STUDIES 18 2. MATERIALS AND METHODS ................................................................................................................. 19 2.1. PREPARATION OF RECEPTORS 19 2.2. ASSAY SYSTEMS 19 2.2.1. IN SOLUTION AR ASSAY 19 2.2.2. IMMUNO-IMMOBILISED RECEPTOR ASSAY (IRA) 20 2.2.3. PR AND SHBG ASSAYS 21 2.2.4. DATA EVALUATION 21 2.3. ANALYTES 22 3. RESULTS AND DISCUSSION ................................................................................................................. 23 3.1. DEVELOPMENT OF NEW ASSAY SYSTEMS 23 3.1.1. BAR ASSAY 23 3.1.2. CLONING OF THE HUMAN AR AND PRODUCTION OF FUNCTIONAL PROTEIN 24 3.1.3. DEVELOPMENT OF A SCREENING ASSAY ON MICROTITRE PLATES (IRA) 25 3.2.
    [Show full text]
  • CS Moonee Valley Racing Club
    CASE STUDY upbeatmembership.compa.com.au Moonee Valley Racing Club At a glance Company Moonee Valley Racing Club Industry Horse Racing Clubs Location Moonee Ponds, Victoria, 3039 Solution Upbeat, Microsoft D365 CE, ClickDimensions, Microsoft Dynamics GP, Scribe Function Membership Engagement and Loyalty Management Race Day Event Management and Ticketing Private and Corporate Function Management Corporate Sponsorship Management Key Points ● Moonee Valley Racing Club (MVRC) has been a significant part of Victoria’s racing history for more than 135 years. In addition to racing, the Club’s core activities include functions, events and gaming venue operations. ● As a member-based organisation, MVRC recognised the need to upgrade their membership management system to better service their commercial and operational requirements and provide improved integration into their other core systems. ● Upbeat within Microsoft Dynamics CRM, and with full integration to Microsoft Dynamics GP, helped MVRC meet their objectives by automating tasks, streamlining processes, and providing data-based insights to drive action. ● Significant wins and improvements have been experienced including delivery of e-Ticketing functionality; facilitation of a streamlined membership-by-instalment process; an improved ability to liaise between teams regarding event bookings; provision of a single version of the truth for event, member and customer data; and a streamlined loyalty process. © Copyright Professional Advantage Page 2 of 8 The Company Moonee Valley Racecourse (“The Valley”) has been a significant part of Victoria’s racing history for more than 135 years. The Club’s signature race, the Ladbrokes W.S. Cox Plate, is celebrated as The Weight-for-Age Championship of Australia, with past winners including Phar Lap, Kingston Town, Might and Power, Sunline and Winx.
    [Show full text]
  • (Cyp19a1b-GFP) Zebrafish Embryos
    Screening Estrogenic Activities of Chemicals or Mixtures In Vivo Using Transgenic (cyp19a1b-GFP) Zebrafish Embryos Franc¸ois Brion1, Yann Le Page2, Benjamin Piccini1, Olivier Cardoso1, Sok-Keng Tong3, Bon-chu Chung3, Olivier Kah2* 1 Unite´ d’Ecotoxicologie in vitro et in vivo, Direction des Risques Chroniques, Institut National de l’Environnement Industriel et des Risques (INERIS), Verneuil-en- Halatte, France, 2 Universite´ de Rennes 1, Institut de Recherche Sante´ Environnement & Travail (IRSET), INSERM U1085, BIOSIT, Campus de Beaulieu, Rennes France, 3 Taiwan Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan Abstract The tg(cyp19a1b-GFP) transgenic zebrafish expresses GFP (green fluorescent protein) under the control of the cyp19a1b gene, encoding brain aromatase. This gene has two major characteristics: (i) it is only expressed in radial glial progenitors in the brain of fish and (ii) it is exquisitely sensitive to estrogens. Based on these properties, we demonstrate that natural or synthetic hormones (alone or in binary mixture), including androgens or progestagens, and industrial chemicals induce a concentration-dependent GFP expression in radial glial progenitors. As GFP expression can be quantified by in vivo imaging, this model presents a very powerful tool to screen and characterize compounds potentially acting as estrogen mimics either directly or after metabolization by the zebrafish embryo. This study also shows that radial glial cells that act as stem cells are direct targets for a large panel of endocrine disruptors, calling for more attention regarding the impact of environmental estrogens and/or certain pharmaceuticals on brain development. Altogether these data identify this in vivo bioassay as an interesting alternative to detect estrogen mimics in hazard and risk assessment perspective.
    [Show full text]
  • In the Winx of an Eye She Became
    4 FAREWELL WINX In the Winx of an eye she became A LEGEND AS WE BID FAREWELL TO WINX, ONE OF THE BEST GALLOPERS TO EVER HIT THE TRACK ANYWHERE IN THE WORLD, BRAD GRAY REFLECTS ON HER FIVE MOST MEMORABLE WINS IN HER HOME STATE – NO EASY TASK! Winx has left us with our hearts in our mouths, jaws on the floor and wonder in our eyes. What a remarkable career. We salute you Winx. DONCASTER MILE, 2016 Think about this for a moment … 1in Winx’s Doncaster win she gave Happy Clapper 6kg. That is 8kg before the mare’s allowance, and she was only four-years-old too. After settling down with just three runners behind her, Hugh Bowman was niggling the daughter of Street Cry approaching the 600m but once she squeezed through the pack halfway down the straight, she strode clear to win by two lengths going away. Bowman admitted he was as worried as onlookers in the run. This was the day Chris Waller conceded he had a champion on his hands. RIGHT: Hugh Bowman salutes the crowd after Winx’s epic Doncaster Mile victory in 2016 GEORGE RYDER STAKES, 2017 Breathtaking. Winx made a habit of 2winning this race but none were more dominant that the 2017 edition where she annihilated a field that included Le Romain and Chautauqua, with nine Group Ones between them. The wet track certainly played into her hands but after she idled up the leaders at the 400m it was just a matter of margins. It was 7.3 lengths in the end.
    [Show full text]
  • Drug Name Plate Number Well Location % Inhibition, Screen Axitinib 1 1 20 Gefitinib (ZD1839) 1 2 70 Sorafenib Tosylate 1 3 21 Cr
    Drug Name Plate Number Well Location % Inhibition, Screen Axitinib 1 1 20 Gefitinib (ZD1839) 1 2 70 Sorafenib Tosylate 1 3 21 Crizotinib (PF-02341066) 1 4 55 Docetaxel 1 5 98 Anastrozole 1 6 25 Cladribine 1 7 23 Methotrexate 1 8 -187 Letrozole 1 9 65 Entecavir Hydrate 1 10 48 Roxadustat (FG-4592) 1 11 19 Imatinib Mesylate (STI571) 1 12 0 Sunitinib Malate 1 13 34 Vismodegib (GDC-0449) 1 14 64 Paclitaxel 1 15 89 Aprepitant 1 16 94 Decitabine 1 17 -79 Bendamustine HCl 1 18 19 Temozolomide 1 19 -111 Nepafenac 1 20 24 Nintedanib (BIBF 1120) 1 21 -43 Lapatinib (GW-572016) Ditosylate 1 22 88 Temsirolimus (CCI-779, NSC 683864) 1 23 96 Belinostat (PXD101) 1 24 46 Capecitabine 1 25 19 Bicalutamide 1 26 83 Dutasteride 1 27 68 Epirubicin HCl 1 28 -59 Tamoxifen 1 29 30 Rufinamide 1 30 96 Afatinib (BIBW2992) 1 31 -54 Lenalidomide (CC-5013) 1 32 19 Vorinostat (SAHA, MK0683) 1 33 38 Rucaparib (AG-014699,PF-01367338) phosphate1 34 14 Lenvatinib (E7080) 1 35 80 Fulvestrant 1 36 76 Melatonin 1 37 15 Etoposide 1 38 -69 Vincristine sulfate 1 39 61 Posaconazole 1 40 97 Bortezomib (PS-341) 1 41 71 Panobinostat (LBH589) 1 42 41 Entinostat (MS-275) 1 43 26 Cabozantinib (XL184, BMS-907351) 1 44 79 Valproic acid sodium salt (Sodium valproate) 1 45 7 Raltitrexed 1 46 39 Bisoprolol fumarate 1 47 -23 Raloxifene HCl 1 48 97 Agomelatine 1 49 35 Prasugrel 1 50 -24 Bosutinib (SKI-606) 1 51 85 Nilotinib (AMN-107) 1 52 99 Enzastaurin (LY317615) 1 53 -12 Everolimus (RAD001) 1 54 94 Regorafenib (BAY 73-4506) 1 55 24 Thalidomide 1 56 40 Tivozanib (AV-951) 1 57 86 Fludarabine
    [Show full text]
  • =Winx (AUS) Bay Mare; Sep 14, 2011 Mr
    equineline.com Product 40P 10/22/16 06:52:51 EDT =Winx (AUS) Bay Mare; Sep 14, 2011 Mr. Prospector, 70 b Machiavellian, 87 dk b/ Coup de Folie, 82 b Street Cry (IRE), 98 dk b/ =Troy (GB), 76 b Helen Street (GB), 82 b =Winx (AUS) =Waterway (FR), 76 ch Success Express, 85 b Foaled in Australia =Al Akbar (AUS), 90 b =Vegas Showgirl (NZ), 02 =Gala Night, 84 b b Voodoo Rhythm, 77 b =Vegas Magic (AUS), 85 =Vegas Street (NZ), 76 gr b By STREET CRY (IRE) (1998). Horse of the year in United Arab Emirates, Stakes winner of $5,150,837 USA in N.A. and United Arab Emirates, Stephen Foster H. [G1] (CD, $516,615), etc. Leading sire in Australia, sire of 11 crops of racing age, 1877 foals, 1276 starters, 108 stakes winners, 7 champions, 874 winners of 2661 races and earning $113,607,566 USA, including Zenyatta (Horse of the year in U.S., $7,304,580, Breeders' Cup Classic [G1] (OSA, $2,700,000), etc.), Winx (Champion in Australia, to 5, 2016, $5,596,858 USA, The Star Doncaster Mile [G1], etc.), Shocking (Champion in Australia, $4,561,399 USA, Emirates Melbourne Cup [G1], etc.), Street Sense (Champion in U.S., $4,383,200, Kentucky Derby [G1] (CD, $1,450,000), etc.). 1st dam =VEGAS SHOWGIRL (NZ), by =Al Akbar (AUS). 7 wins, 2 to 4 in AUS and NZ , $148,523 (USA), Leila MacDonald Soliloquy S., New Zealand Bloodstock Two-Year-Old Fillies S., 2nd Hawkeye @ Stoney Bridge S. [G3], Sheraco S., Gould Photographics Rotorua S., Life Members Wellesley S.
    [Show full text]
  • Black Caviar to Visit Written Tycoon As Prince of Caviar Retires to Riverbank | 2 | Friday, August 7, 2020
    Friday, August 7, 2020 | Dedicated to the Australasian bloodstock industry - subscribe for free: Click here Black Caviar to visit Written What's on Tycoon as Prince Of Caviar Race meetings: Tamworth (NSW), Ballarat (VIC), Ipswich (QLD), Canberra (ACT), Wingatui (NZ) retires to Riverbank Barrier trials / Jump-outs: Warwick Farm The champion sprinter will be served by a sixth separate (NSW), Tamworth (NSW), Flemington (VIC), Canberra (ACT) stallion with Arrowfield Stud’s new arrival her next suitor International meetings: Taipa (MAC), Sandown (UK), Yarmouth (UK), Hamilton (UK), Fairview (SAF), Saratoga (USA), Del Mar (USA) International Group races: Saratoga (USA) - Saratoga Special (Gr 2, 6f). Del Mar (USA) - Sorrento Stakes (Gr 2, 6f) Black Caviar with Prince of Caviar as a foal It was also announced yesterday that Black BY ANDREW HAWKINS AND ALEX WILTSHIRE Caviar will visit Arrowfield Stud’s new addition iverbank Farm will have close Written Tycoon (Iglesia) this season, with her named I Am Caviar; she was last covered in late relations to two of Australia’s daughter and first foal Oscietra (Exceed And December last year. champion mares at stud this Excel) bound for Swettenham Stud’s Toronado That followed visits to Exceed And Excel season, with Black Caviar’s (Bel (High Chaparral). (Danehill), which produced Oscietra; Sebring Esprit)R son Prince Of Caviar (Sebring) joining Black Caviar has visited Yarraman Park’s I (More Than Ready), with the resultant Prince Winx’s (Street Cry) half-brother Boulder City Am Invincible (Invincible Spirit) the last three Of Caviar; Snitzel (Redoute’s Choice), with Out (Snitzel) on the roster at the Benalla stud.
    [Show full text]
  • 伊域化學藥業（香港）有限公司 Cyclopentyl Substituted Compounds
    ® 伊 域 化 學（香 藥 香 港） 業 港有 有 限 限 公 公 司 司 YICK-VIC CHEMICALS & PHARMACEUTICALS (HK) LTD Rm 1006, 10/F, Hewlett Centre, Tel: (852) 25412772 (4 lines) No. 52-54, Hoi Yuen Road, Fax: (852) 25423444 / 25420530 / 21912858 Kwun Tong, E-mail: [email protected] YICKYICK----VICVICVICVIC 伊域伊域伊域 Kowloon, Hong Kong. Site: http://www.yickvic.com Cyclopentyl Substituted Compounds Product Code CAS Product Name CC-0052BA 39746-00-4 (-)-COREY LACTONE BENZOATE CC-3702AD 1211-29-6 (-)-METHYL JASMONATE SPI-4467C 87269-86-1 (-)-OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID HYDROCHLORIDE SPI-4467A 93779-30-7 (+/-)-OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID HYDROCHLORIDE SPI-2956FG 142217-81-0 (1S,3R,4S)-2-AMINO-9-(4-BENZYLOXY)-3-(BENZYLOXYMETHYL)-2-METHYLIDENECYCLOPENTYL-3H-PURINE-9-ONE SPI-2956FJ 142217-78-5 (2R,3S,5S)-3-(BENZYLOXY)-5-[2-[[(4-METHOXYPHENYL)DIPHENYLMETHYL]AMINO]-6-(PHENYLMETHOXY)-9H-PURIN-9-Y L]-2-(BENZYLOXYMETHYL)CYCLOPENTANOL SPI-1560DH 4167-77-5 1,1-CYCLOPENTANEDICARBOXYLIC ACID DIETHYL ESTER SPI-2808C 5763-44-0 1,2-CYCLOPENTANE DICARBOXIMIDE CC-1957B 1222-05-5 1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYLCYCLOPENTA[G]-2-BENZOPYRAN SPI-1246B 3859-41-4 1,3-CYCLOPENTANEDIONE SPI-1955AA 646-06-0 1,3-DIOXOLANE SPI-3082AA 54078-29-4 1,8-DIAZAFLUOREN-9-ONE UNIE-13864 564-35-2 11-KETOTESTOSTERONE SPI-0098CA 640-87-9 17-ALPHA,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE 21-ACETATE UNIE-13126 302-76-1 17ALPHA-METHYL-17BETA-ESTRADIOL UNIE-14695 3563-27-7 17BETA-DIHYDROQUILIN UNIE-2836 10316-79-7 1-AMINO-1-CYCLOPENTANEMETHANOL SPI-3077CB 61379-64-4 1-AMINO-4-CYCLOPENTYLPIPERAZINE
    [Show full text]
  • Pharmaceuticals Appendix
    )&f1y3X PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 3 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABAMECTIN 65195-55-3 ADAPALENE 106685-40-9 ABANOQUIL 90402-40-7 ADAPROLOL 101479-70-3 ABECARNIL 111841-85-1 ADEMETIONINE 17176-17-9 ABLUKAST 96566-25-5 ADENOSINE PHOSPHATE 61-19-8 ABUNIDAZOLE 91017-58-2 ADIBENDAN 100510-33-6 ACADESINE 2627-69-2 ADICILLIN 525-94-0 ACAMPROSATE 77337-76-9 ADIMOLOL 78459-19-5 ACAPRAZINE 55485-20-6 ADINAZOLAM 37115-32-5 ACARBOSE 56180-94-0 ADIPHENINE 64-95-9 ACEBROCHOL 514-50-1 ADIPIODONE 606-17-7 ACEBURIC ACID 26976-72-7 ADITEREN 56066-19-4 ACEBUTOLOL 37517-30-9 ADITOPRIME 56066-63-8 ACECAINIDE 32795-44-1 ADOSOPINE 88124-26-9 ACECARBROMAL 77-66-7 ADOZELESIN 110314-48-2 ACECLIDINE 827-61-2 ADRAFINIL 63547-13-7 ACECLOFENAC 89796-99-6 ADRENALONE 99-45-6 ACEDAPSONE 77-46-3 AFALANINE 2901-75-9 ACEDIASULFONE SODIUM 127-60-6 AFLOQUALONE 56287-74-2 ACEDOBEN 556-08-1 AFUROLOL 65776-67-2 ACEFLURANOL 80595-73-9 AGANODINE 86696-87-9 ACEFURTIAMINE 10072-48-7 AKLOMIDE 3011-89-0 ACEFYLLINE CLOFIBROL 70788-27-1
    [Show full text]
  • NSW's at Forefront of Black Type Racing
    40 NSWNSW RACEHORSE RACEHORSE OWNERS OWNERS ASSOCIATION ASSOCIATION What many opponents see as Winx (Hugh Bowman) sails past – the mare started her spring campaign in brilliant fashion once again recording three Group 1 wins from as many runs to date NSW’s at forefront of black type racing The evergreen Ball of Muscle (Glyn Schofield) has recorded two Group 2 wins and a Group 3 success this season (at time of print) www.racingnsw.com.au 41 FOR OWNERS THE EXPERIENCE OF WINNING A RACE IS SOMETHING TO CHERISH - NOTHING BEATS THE EUPHORIA OF WINNING. IN SHORT, IT’S SIMPLY FANTASTIC! WORDS: SHARON HUNT (EXECUTIVE OFFICER – NSWROA) ut to be able to win a black type race, well, that is Of the 27 Group 3 race winners, 16 of those have been something else again. A black type win is something won by NSW – a 59.25% success rate. And finally, NSW has most of us can only dream of with a Group 1 win the recorded 10 Listed Race wins to date out of the 30 events held pinnacle! – a 33.33% success rate. BAt the time of writing the first two months of the 2018-2019 Five NSW-trained horses have recorded dual black type racing season have just been completed and the various spring wins to 30 September 2018. Leading the way is Winx who has carnivals are underway. three Group 1 wins (the Winx Stakes, George Main Stakes and It’s that very exciting time of year when the stars of the track Turnbull Stakes) to her credit.
    [Show full text]
  • (Anti-)Androgenic Activities in Aquatic Environments?
    Environmental Pollution 242 (2018) 417e425 Contents lists available at ScienceDirect Environmental Pollution journal homepage: www.elsevier.com/locate/envpol Do progestins contribute to (anti-)androgenic activities in aquatic environments?* * Pavel Sauer , Adam Borík, Oksana Golovko, Roman Grabic, Andrea Vojs Stanov a, Olga Valentova, Alzbeta Stara, Marie Sandova, Hana Kocour Kroupova University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Research Institute of Fish Culture and Hydrocenoses, Zati sí 728/II, 389 25 Vodnany, Czech Republic article info abstract Article history: Unknown compounds with (anti-)androgenic activities enter the aquatic environment via municipal Received 21 May 2018 wastewater treatment plants (WWTPs). Progestins are well-known environmental contaminants capable Received in revised form of interfering with androgen receptor (AR) signaling pathway. The aim of the present study was to 28 June 2018 determine if 15 selected progestins have potential to contribute to (anti-)androgenic activities in Accepted 30 June 2018 municipal wastewaters and the respective recipient surface waters. AR-specific Chemically Activated Available online 4 July 2018 LUciferase gene eXpression bioassay in agonistic (AR-CALUX) and antagonistic (anti-AR-CALUX) modes and liquid chromatography tandem atmospheric pressure chemical ionization/atmospheric photoioni- Keywords: Progestagens zation with hybrid quadrupole/orbital trap mass spectrometry operated in high resolution product scan Solid-phase extraction mode (LC-APCI/APPI-HRPS) methods were used to assess (anti-)androgenic activity and to detect the Target analysis target compounds, respectively. The contribution of progestins to (anti-)androgenic activities was Sample acidification evaluated by means of a biologically and chemically derived toxicity equivalent approach.
    [Show full text]