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An Overview of Feline Coat Colour Genetic Pet Care

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An Overview of Feline Coat Colour Genetic Pet Care An Overview of Feline Coat Colour Genetic Pet Care June 2014 Please Note: Feline coat colour cannot be determined by a DNA test alone. There are a number of genes that cannot be determined via genetics and infl uence coat colour. These include the O (orange/red) gene, ORIVET GENETIC PET CARE the W (dominant white) gene, the Silver gene and the S (spotting) gene. To determine the coat colour of a Suite 102A/163-169 Inkerman Street cat the genetic information, pedigree and a photo of the cat tested is required. St Kilda 3182 Australia The nomenclature used to report traits may vary from laboratory to laboratory. In general all results are PO Box 110 reported as NORMAL (does not carry the mutation), CARRIER (carries one copy) or AFFECTED (has two St Kilda 3182 VIC Australia copies). All aff ected animals will show that trait. The nomenclature used below is that as established and published by Dr Lesley Lyons. t +61 3 9534 1544 f +61 3 9525 3550 DILUTE (BLACK to GREY/BLUE; ORANGE to CREAM) © Copyright 2014 Orivet MLPH gene c.83delT mutation Reference: Ishida Y, David VA, Eizirik E, et al. A homozygous single-base deletion in MLPH causes the dilute coat color phenotype in the > DNA Disease Screening domestic cat. Genomics. Jul 20 2006. > DNA Traits testing RESULT INTERPRETATION – BREEDNG OUTCOMES > Canine Breed Identifi cation Has two copies of the dilute allele (d/d). Coat colour is diluted as follows: > DNA Profi ling and Parentage d/d – DILUTE Black is diluted to Blue / Chocolate is diluted to Lilac / Cinnamon is Confi rmation diluted to Fawn / Red is diluted to Cream. > Personalised Genetic Health Has one copy of the Dilute allele (D/d) cat is a Carrier of dilute. Wellness Plans D/d – CARRIER of DILUTE No dilution of coat colour. May produce a dilute off spring if mated > Genetic Pet Care Program for with another carrier. Veterinarians Has no copies of the Dilute allele (D/D) the cat is full colour. > All Natural Pet Care Products D/D – DOES NOT CARRY DILUTE No dilution of coat colour. Will not produce any dilute off spring. > Optimal Breed Selection AGOUTI (BANDED HAIR to SOLID) ASIP gene c.122_123delCA Mutation Reference: Eizirik E, Yuhki N, Johnson WE, Menotti-Raymond M, Hannah SS, O’Brien SJ. Molecular genetics and evolution of melanism in the cat family. Curr Biol. Mar 4 2003;13(5):448-453. RESULT INTERPRETATION – BREEDNG OUTCOMES Has two copies of the Agouti gene (A/A). Cat will have agouti banded A/A – AGOUTI hair. All off spring will have agouti or banded hair. Has one copy of the Agouti gene and one copy of the non-Agouti A/a – CARRIER OF NON-AGOUTI gene (A/a). Cat will have agouti banded hair and off spring can be agouti or non-agouti depending on the genetics of the breeding pair. Has two copies of the non-Agouti gene (a/a). Cat will have solid a/a – NON –AGOUTI colouration. If this cat is bred to a non-agouti then only non-agouti off spring will be produced. Personal Animal Genetics www.orivet.com.au 3677GRIT An Overview of Feline Coat Colour AMBERAMBER/EXTENSION (BROWN/RED COLOR VARIANT) MC1R gene c.250G>A Reference: Peterschmitt M, Grain F, Arnaud B, Deleage G, Lambert V. Mutation in the melanocortin 1 receptor is associated with amber colour in the Norwegian Forest Cat. Animal Genet. Aug 2009;40(4):547-552. RESULT INTERPRETATION – BREEDNG OUTCOMES Has two copies of the Amber mutation (e/e). Cat will have Amber colouration (in the e/e – AMBER absence of Orange). E/e – CARRIER OF AMBER Has one copy of the Amber mutation (E/e). Cat will not have Amber colouration. E/E – DOES NOT CARRY AMBER Has no copies of the Amber mutation (E/E). Cat will not have Amber colouration. BROWN (CHOCOLATE AND CINNAMON) TYRP1 gene b=c.8>G/bl = c.298C>T Reference: Lyons LA, Foe IT, Rah HC, Grahn RA. Chocolate coated cats: TYRP1 mutations for brown color in domestic cats. Mamm Genome. May 2005;16(5):356-366. Schmidt-Kuntzel A, Eizirik E, O’Brien SJ, Menotti-Raymond M. Tyrosinase and tyrosinase related protein 1 alleles specify domestic cat coat color phenotypes of the albino and brown loci. J Hered. Jul-Aug 2005;96(4):289-301. RESULT INTERPRETATION – BREEDNG OUTCOMES b/b – CHOCOLATE Has two copies of the Chocolate allele (b/b). Cat is Chocolate (Brown). Has one copy of the Chocolate allele (B/b). Full colour or possibly Chocolate if the cat B/b – CARRIER OF CHOCOLATE also carries Cinnamon. Full colour cat does not carry brown or cinnamon alleles. Has no copies of the B/B – DOES NOT CARRY ANY CHOCOLATE Chocolate allele (B/B). b l/ b l – CINNAMON Has two copies of the Cinnamon allele (b l/ b l). Cat is Cinnamon. Has one copy of the Cinnamon allele (B/ b l or b/ b l). Full colour or possibly Chocolate if B/ b l or b/ b l – CARRIER OF CINNAMON the cat also carries Chocolate. Full colour – Has no copies of the Cinnamon allele (B/B, B/b or b/b). Full colour or B/B, B/b or b/b – DOES NOT CARRY CINNAMON possibly Chocolate. COLOURPOINT RESTRICTION (BURMESE AND SIAMESE COLOUR PATTERN) TYR gene cb = c.715G>T, cs = c.940G>A, c = c.975delC References: Schmidt-Kuntzel A, Eizirik E, O’Brien SJ, Menotti-Raymond M. Tyrosinase and tyrosinase related protein 1 alleles specify domestic cat coat color phenotypes of the albino and brown loci. J Hered. Jul-Aug 2005;96(4):289-301. Imes DL, Geary LA, Grahn RA, Lyons LA. Albinism in the domestic cat (Felis catus) is associated with a tyrosinase (TYR) mutation. Animal Genet. Apr 2006;37(2):175-178. Lyons LA, Imes DL, Rah HC, Grahn RA. Tyrosinase mutations associated with Siamese and Burmese patterns in the domestic cat (Felis catus). Animal Genet. Apr 2005;36(2):119-126. RESULT INTERPRETATION – BREEDNG OUTCOMES CC – NO COLOURPOINT Full colour. The cat does not carry any Burmese (sepia) or Siamese alleles. Full Colour. Has one copy of the Burmese (sepia) colour. Carries the C/c b gene. C/c b – CARRIER of BURMESE COLOUR If mated with another carrier of Burmese colour MAY produce a Burmese kitten.. C/c s – CARRIER of SIAMESE COLOURPOINT Full colour. Has one copy of the Siamese colourpoint restriction. Carries the C/c s gene. RESTRICTION If mated with another carrier of Siamese colourpoint MAY produce a Siamese kitten. c b/ c b Cat is Burmese (sepia). All off spring will be at least carriers of Burmese c b. c s/ c s Cat is Siamese. All off spring will be at least carriers of Burmese c s. c b/ c s Mink, cat has an intermediate colour between Burmese and Siamese.. Personal Animal Genetics www.orivet.com.au An Overview of Feline Coat Colour WHITE GLOVES – WHITE FEET/BIRMAN PATTERN KIT gene RESULT INTERPRETATION – BREEDNG OUTCOMES The cat is normal for the mutation and does not have any of the Birman gloving mutation. N/N – NO GLOVE PATTERN Will NOT produce any gloving off spring. Has one copy of the gloving mutation. Carrier for the mutation if mated with another N/G – CARRIER OF GLOVING PATTERN carrier MAY produce a gloving pattern kitten. G/G – GLOVES ARE PRESENT Has two copies of the gloving pattern. Cat will have gloving pattern. ALBINISM RESULT INTERPRETATION – BREEDNG OUTCOMES The cat is normal for the mutation and does not have any of the Albino mutation. N/N – NO ALBINO GENE Will NOT produce any albino off spring. Has one copy of the albino mutation. Carrier for the mutation if mated with another A/N – CARRIER OF ALBINO GENE carrier MAY produce an albino off spring. A/A – CAT IS ALBINO Has two copies of the albino mutation. Cat is albino. Personal Animal Genetics www.orivet.com.au.
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