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VITAE

Name: Richard Banfield Marchase

Address: The of at Birmingham (UAB) 701 20th Street South, UAB Administration Building 720 Birmingham, AL 35294 Phone: (205) 934-1294

Education

The Doctor of Philosophy 1976 Biophysics with distinction

Cornell University Bachelor of 1970 Engineering Physics with distinction

Professional Background

2012-2013 Interim President, UAB 2005-present Vice President for Research and Economic Development, Professor of Cell Biology, UAB 2004-2005 Interim Vice President for Research, UAB 2000-2006 Associate Dean and then Senior Associate Dean for Biomedical Research, School of Medicine, UAB 1994-2000 Chairman, Department of Cell Biology, UAB 1991-1994 Interim Chairman, Department of Cell Biology, UAB 1990-1992 Director of Graduate Studies, Cell Biology, UAB 1990-present Professor of Cell Biology, UAB 1986-present Member of Graduate Faculty, UAB 1986-1990 Associate Professor of Cell Biology and Anatomy, UAB 1978-1986 Assistant Professor, Department of Anatomy, Medical Center 1976-1978 Postdoctoral Fellow, Duke University Medical Center

Honors and Fellowships

2012 Charter Fellow, National Academy of Inventors 2010 Fellow, American Association of Anatomists 2010 A.J. Ladman Exemplary Service Award of the American Association of Anatomists 1999 Mary Jane Kugle Award, Juvenile Diabetes Foundation International 1984-1989 National Science Foundation Presidential Young Investigator Award 1984-1986 Exxon Education Foundation Presidential Young Investigator Matching Funds 1982-1985 Nanaline H. Duke Scholarship (Junior Faculty Research Award, Duke) 1978-present Sigma Xi 1977-1978 National Institutes of Health, Postdoctoral Fellowship 1976-1977 Muscular Dystrophy Association, Postdoctoral Fellowship

1 1975 Danforth Foundation Supplemental Grant for the Improvement of 1972-1975 Danforth Foundation Graduate Fellowship 1970-1972 National Science Foundation Graduate Fellowship 1970 Hamilton Watch Award (Outstanding Graduate in Science and Engineering) 1970 First in class, Cornell University of Engineering 1969 Tau Beta Pi

Past Extramural Support

Institutional:

HHMI Biomedical Research Support Program for Medical Schools 2000-2003

HRSA, 4C76HF00120 2000-2005 Construction of Shelby Building

NIAID, 1UC6AI058599 2003-2008 Construction of SEBLAB – A Regional Biocontainment Laboratory

NCRR, 1C06RR020136 2004-2006 Phase 2, Construction of Levels 6 and 11 of the Shelby Building

NCRR, 1C06RR018847 2003-2008 Phase 1, Construction of the Research Support Building

NIAID, 3UC6 AI058599-01S1 2003-2008 Construction/SEBLAB/Regional Biocontainment Laboratory Supplemental Agreement

NIAID, 3UC6 AI058599-01S2 2006-2008 Construction/SEBLAB/Regional Biocontainment Laboratory Supplemental Agreement

National Institute of Standards & Technology, DOC 60NANB6D6166 Construction of Interdisciplinary Biomedical Research Complex

Research:

NIH RO1 EY-02845, Ligatin: A Baseplate Protein in Retinotectal Adhesion, 1978-1981.

NSF PCM 78-06060, Cell Recognition During Early Embryogenesis of Sea Urchins (D. McClay, P.I.; R. Marchase, co-P.I.), 1978-1980.

NIH P50 NS-06233, Duke-VA Center for Cerebrovascular Research (J.N. Davis, Center Director); Project: Intercellular Adhesive Specificities in the CNS (R.B. Marchase, P.I.), 1980-1986.

NIH RO1 HD-14483, Cell Recognition during Early Embryogenesis of Sea Urchins (D. McClay, P.I.; R.B. Marchase, co-P.I.), 1980-1983.

NIH RO1 EY-04480, Cell Surface Molecules in Embryonic Cell Adhesion (D. McClay, P.I.; R.B. Marchase, co-P.I.), 1982-1985.

2 Nanaline H. Duke Scholarship for Junior Faculty Research Support, Duke University, 1982-1985.

NIH RO1 GM-31381, Phosphoglucosyltransferase and Subcellular Localization, 1983-1986.

NSF DCB-8641003, Presidential Young Investigator Award, 1984-1989.

Exxon Education Foundation, NSF Presidential Young Investigator Matching Award, 1984-1986.

NIH RO1 EY-05861, Glycoproteins Containing Phosphoglucose from Neural Retina, (changed to EY-06714 with institution change), 1985-1986.

Ciba Geigy Corporation, Phosphodiester-Linked Glucose as a Potential Signal for Receptor- Mediated Endocytosis by the Intestinal Epithelial, 1985-1987.

NSF Undergraduate Research Supplement, 1987.

NIH RO1 EY-06714, Glycoproteins Containing Phosphoglucose from Neural Retina, 1986-1990.

NEN Dupont, Phosphorothioate Analogues of Nucleotide Sugars, 1987-1990.

NSF DIR-89 15955, Acquisition of Laser Scanning Confocal Microscope (M. Friedlander, P.I.), 1989- 1991.

NIH 1P50 DK42017, Cell and Molecular Biology of Secretory Cl Channels, (D. Benos, P.I.), Project:Immunocytochemistry and Intracellular Trafficking, (R.B. Marchase, P.I.). Core: Cell Culture and Molecular Probes, (R.B. Marchase, Core Director), 1989-1994.

NIH 5 P60 AR20614 Multiple Purpose Arthritis & Musculoskeletal Diseases Center (W. Koopman, Director); Project: Reversible Phosphoglycosylation May Mediate Phagocytosis (R.B. Marchase, P.I.) 1992-1994.

American Diabetes Association, Inc., Glucose Metabolites and Calcium Regulation in Diabetes, 1995-1997.

NIH RO1 EY-06714-09, Glycoproteins Containing Phosphoglucose in Neural Retina, 1990-1996.

Cystic Fibrosis Foundation, R464, Immunomodulation in the Lung by Glc and its Analogues, R.B. Marchase, P.I. Project, Co-Director, Core A, 1995-1996.

Juvenile Diabetes Foundation International Interdisciplinary Research Program, 995002, Cytoplasmic O-Glycosylation and Diabetic Glucotoxicity, Program Director, P.I. Project 1, Director Core A, 1995-2000.

American Diabetes Association, Hyperglycemia and NF-AT-Mediated Cytokine Transcription, 1998- 2001.

Juvenile Diabetes Research Foundation, 1-2000-137, Impaired Capacitative Calcium Entry in Type I Diabetes: Understanding the Mechanism(s) Responsible for Increased Susceptibility to Infection, 1999-2003.

NIH R01 DK55647, Ca Influx Factor: Structure/Function & Role in Diabetes, 2000-2004

3 2+ NIH 1RO1 HL68806-01 (Blalock, P.I., Marchase, Co-Investigator) Epithelial [Ca ]i Channels as Therapeutic Targets in Asthma, 2001-2004.

DOD, DARPA (Chaudry, P.I., Marchase Co-Inv.) Enhanced Survival Following Trauma-Hemorrhage and Extended Period of Hypertension Using Hormonal and Metabolic Support (ESTHEPH-HMS), 2004-2006.

NIH RHL076175, Cytoplasmic Glycosylation and Hypovolemic Stress 2004-2009

NIH SCCOR in Cardiac Dysfunction and Disease (Dell’Italia, P.I.) The Impact on Diabetes on Left Ventricular Remodeling (Chatham, P.I., Marchase, Consultant, Project 3) 2005-2009

NHLBI R01HL67464, (Chatham, P.I., Marchase, Consultant) Type 2 Diabetes and Cardiac Dysfunction 2005-2010

NHLBI R01HL079364 (Chatham, P.I., Marchase, Consultant) Mechanisms of Glucosamine Cardioprotection 2006-2011

National Responsibilities

1992-1998 American Society for Cell Biology Congressional Liaison Committee 1994-1996 President-elect and then President of the Association of Anatomy, Cell Biology, and Neurobiology Chairpersons 1994-2000 National Caucus of Basic Biomedical Science Chairs 1995-1997 American Association of Anatomists Nominations Committee 1997-2000 Council of Academic Societies Representative of the Association of Anatomy, Cell Biology, Neurobiology Chairpersons 1998-1999 Association of American Medical Council of Academic Societies Program Committee 1999 Association of American Medical Colleges Mission-Based Management Research Panel 1998-2001 American Association of Anatomists Representative to the FASEB Federal Funding Consensus Conference 2000-2006 Association of American Medical Colleges Group on Research Advancement and Development, Steering Committee 2001-2006 Federation of American Societies for Experimental Biology, (FASEB), Board of Directors 2001-2007 American Association of Anatomists Public Affairs Executive Committee 2001-2003 FASEB Board Finance Committee and Audit Subcommittee 2002-2003 FASEB Board Capital Campaign Committee 2002-2003 FASEB Chair for National Science Foundation, Federal Funding Consensus Conference 2003-2010 FASEB Public Affairs Committee 2004-2006 Association of American Medical Colleges David E. Rogers Award Review Committee 2004 FASEB Communications Task Force 2004-2005 FASEB Chair of Strategic Planning Governance Subcommittee 2004-2006 FASEB Strategic Planning Task Force 2005-2006 FASEB Vice President for Science Policy 2005-present FASEB NIH Issues Subcommittee 2005-2007 FASEB Strategic Plan Oversight Committee

4 2007-2009 FASEB President-elect, then President, then Past-President 2007-2008 Chair, American Association of Anatomists Nominating Committee 2009-2012 Executive Committee, APLU Council on Research Policy and Graduate Education 2009-2011 FASEB Membership Subcommittee 2010-2013 American Association of Anatomists Publications Committee 2010-present Member, American Association of Task Force on Strengthening the University-Government Research Partnership 2014-present Chair-Elect, APLU Council on Research Policy and Graduate Education

University Responsibilities

Duke University:

1978-1979 Faculty Undergraduate Residential Advisor 1978 Assistant Dean of Students Search Committee 1979-1982 Undergraduate Pre-Major Advisor 1980 Third-year Medical School Advisor 1983-1984 Medical Scientists Training Program (M.D./Ph.D.) Selection Committee 1980-1986 Cell and Molecular Biology Training Program, Executive Committee 1981-1986 Committee on Health Affairs 1982-1986 Neurosciences Steering Committee 1984-1986 Stroke Investigators Training Program, Executive Committee

The at Birmingham:

1986-1991 Animal Resources Finance Subcommittee 1986-1987 Cell Biology and Anatomy Committee on Graduate Examinations 1986-1991 Athletic Advisory Committee 1987-1988 Cell Biology and Anatomy Neuroanatomy Search Committee 1987-1992 Cell and Molecular Biology Training Program Co-Course Master 1987-1995 Cell and Molecular Biology Training Program Curriculum Committee 1987-1992 Executive Committee for Graduate Study in Neuroscience Training Program 1987-1989 Cell and Molecular Biology Training Program Admissions Committee 1988-1989 UAB Distinguished Faculty Lecturer Selection Committee 1988-1989 Psychiatry Chairman Search Committee 1988-1989 Departmental Seminar Committee 1988-1997 Departmental Committee on Graduate Studies 1988-1991 Neurobiology Research Center Faculty Search Committee 1989-1990 Research Scholars in Science and Engineering Planning Committee 1989-1990 NCEA Faculty Mentoring Program Coordinating Committee 1990-1992 Joint Health Faculty Status Committee 1990-1992 Director of Graduate Studies, Department of Cell Biology 1990-2000 Cell and Molecular Biology Training Program Steering Committee 1991-1993 Dean of the Graduate School Search Committee 1991-1992 Biochemistry Chairman Search Committee 1991-1992 Psychiatry Chairman Search Committee 1991-1992 Planning Committee for Neuroscience Training for Medical Students 1991-1994 UAB Advisory Council

5 1991-1994 Interim Chairman, Department of Cell Biology 1992-1993 UAB SACS Self-Study Committee on Faculty 1992-2000 Vision Science Research Center Advisory Committee 1992-1994 UAB Strategic Planning Committee for Research 1993-1994 Chairman, SPCR Subcommittee on Graduate Training 1993-1994 Dean of the School of Optometry Search Committee 1994-1996 Chairman, Graduate Education Committee for Graduate Fellowship Allocation 1994-1997 Department of Physiology and Biophysics Chairman's Search Committee 1994-1996 Research and Development Committee, Multipurpose Arthritis and Musculoskeletal Diseases Center 1994-1997 Joint Health Sciences Faculty Status Committee 1994-present Alzheimer’s Disease Center Internal Advisory Committee 1994-1998 Faculty Athletic Subcommittee on Academic Standards 1995-2000 Basic Science Advisory Committee 1995-2000 Academic Health Center Research Advisory Group (AHC-RAG) 1995-1997 Medical Education Committee Project Curriculum 2000 1995-1998 S. Richardson Hill Visiting Professorship Committee 1995-1998 UAB Strategic Planning Partnership Group 1995-present Executive Committee, Cystic Fibrosis Research Center 1995-2000 Ad hoc Advisory Committee for Research 1996-1998 School of Dentistry Dean’s Search Committee 1998-2000 Chair, Department of Microbiology Search Committee 1997-1999 NCAA Subcommittee on Academic Integrity 1997-2002 Committee on Philanthropy 1998-2000 Chair, Research Advisory Group 2000-2004 SOM Representative, Research Advisory Group 2000-2006 Chair, School of Medicine Research Advisory Committee 2000-2004 Chair, HHMI Institutional Advisory Committee 2000-2002 Co-Chair, Building Committee for the Interdisciplinary Biomedical Sciences Research Building 2002-2006 User Liaison, Building Committee for the Interdisciplinary Biomedical Sciences Research Building 2000-2001 Economic Rules Committee 2001-present Clinical Research Advisory Group 2001-present Research Compliance Steering Committee 2001-2003 Council on Postdoctoral Education 2001-2002 J.W. Goodwin – Warren D. Blackburn, Jr. Research Chair in Rheumatology Selection Committee 2001-2003 Frederick Gardner Cottrell Postdoctoral Enhancement Awards Committee 2001-present UAB-SRI Collaboration Advisory Board 2001-2002 UAB Presidential Search Committee 2002-2006 HSF-GEF Scholar Award Program Committee 2002-2003 Co-Organizer, University Retreat on Biodefense and Emerging Pathogens 2002-2003 Chair, Research Foundation Funding Flow Task Force 2002-2005 School of Dentistry Institutional Planning Committee 2003-2005 Initiative for Life Sciences Entrepreneurship Science Advisory Board 2003-2004 Advisory Committee on Genomics and Clinical Research for the Pittman GCRC 2003-2004 Chair, UAB Research Foundation CEO Search Committee 2004-present UAB Office of Research Compliance Oversight Committee 2004-present Chair, Institutional Advisory Board for the Neurofibromatosis Center

6 2004-present Member, Health Insurance Portability and Accountability Act (HIPAA) Advisory Committee 2004-present UAB’s Board Member to the Space Science & Technology Alliance (SSTA) 2004-present Alabama EPSCoR Steering Committee Representative 2004-present Southern Growth Policies Board Representative 2004-present Mississippi-Alabama Sea Grant Consortium Representative 2004-present Internal Advisory Committee of the Comprehensive Cancer Center 2004-2009 Internal Advisory Committee for the Center for Emergency Care and Disaster Preparedness 2004-present Vice Chair, UAB Research Foundation Board of Directors 2004-present Ex Officio Member, Center for Emergency Care and Disaster Preparedness Executive Committee 2005-present UAB Breast SPORE Internal Advisory Committee 2005-present VA/UAB Affiliation Partnership Council 2006-present UAB Liaison for Federal Governmental Relations 2006-present Internal Advisory Committee of the Diabetes Research Training Center 2006-2009 Chair, Trans-Institutional Advisory Committee 2007-2013 Member, Centre for Infectious Disease Research in Zambia (CIDRZ) Board of Directors 2007-2010 Member, Laboratory for Global Health Advisory Board 2007-2008 Interim CEO, UAB Research Foundation 2006-present Advisor, Council of Center Directors 2012-present Southern Research Institute Board of Directors 2012-2013 Interim Chair, Southern Research Institute Board of Directors 2012-2013 Interim Chair, UAB Research Foundation Board 2012-2013 Interim Chair, UAB Health System Board

Teaching Experience

Developmental Biology Neurobiology I Advanced Cell Biology Medical Neuroanatomy Microscopic Anatomy Cell and Molecular Biology II, III, and IV Developmental Neurobiology Medical Cell & Tissue Biology for Medical Students Introduction to Neurobiology BioTeach Various Seminars and Journal Clubs Cellular and Molecular Neurobiology Clinical and Molecular Physiology and Medicine: Fundamental Insights into Common Diseases Calcium Signaling Journal Club

Doctoral mentor for 20 successful Ph.D. and M.D./Ph.D. students.

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External Scientific Presentations

Selected Seminars:

Illinois, Emory, Chicago, Connecticut, Harvard, Case-Western Reserve, North Carolina State, North Carolina, Maryland, Dorothea Dix, Johns Hopkins, Yale, Harvard Medical School, , Duke University Marine Laboratory, Johns Hopkins, University of Alabama at Birmingham, Washington University, Columbia, Princeton, Emory, M.D. Anderson, City of Hope, Harvard, Iowa, Michigan, LaJolla Cancer, McLean, Virginia, Alberta Medical, NEN Dupont, Albert Einstein College of Medicine, NIDDK, Emory University, Southwest Medical, Johns Hopkins, NIEHS, Medical University of South Carolina, Albert Einstein College of Medicine, Alabama Imaging and Microscopy Society, Medical University of South Carolina, Juvenile Diabetes Foundation, Birmingham Chapter, Juvenile Diabetes Foundation, Charleston Chapter, University of South Alabama, Emory University, State University, Albert Einstein College of Medicine, University of Maryland School of Medicine.

Symposia-Invited Speaker:

1974 Max Planck Conference on Neural Development, Tubingen 1975 Winter Brain Research Conference, Colorado 1976 International Conference on Neural Functioning, London 1979 International Conference on Biological Membranes, Crans-sur-Sierre, Switzerland 1980 Symposium on Ocular and Visual Development, Philadelphia 1981 American Society for Cell Biology Mini-Symposium on Cell Adhesion, Anaheim 1983 Cetus-UCLA Symposium Workshop on Intracellular Sorting of Proteins, Colorado 1983 Meetings in Neural Development, New York 1983 Gordon Conference on Molecular Membrane Biology, New Hampshire 1983 International Society for Developmental Neuroscience, Salt Lake City 1983 Developmental Neurobiology Colloquium, University of North Carolina, Chapel Hill 1984 American Society of Zoologists, Denver 1985 American Society of Zoologists, Baltimore 1985 International Symposium on Molecular Aspects of Neurobiology, Florence 1987 Society for Developmental Biology Southeastern Regional Symposium, St. Augustine 1988 American Chemical Society Regional Symposium, 1989 American Society for Cell Biology - American Society for Biochemistry and Molecular Biology Afternoon Symposium, San Francisco 1990 Cystic Fibrosis Foundation - The Gene: Nine Months Later, Williamsburg 1991 Gordon Conference on Glycoproteins and Glycolipids, Ventura 1992 NIH Cystic Fibrosis Center Directors Roundtable, Washington, D.C. 1993 Cystic Fibrosis Foundation - Beyond the Gene Conference, Williamsburg 1996 Experimental Biology ‘96 - American Association of Anatomists Topology of Calcium Signaling Symposium, Washington, D.C. 1996 NIDDK-JDFI Joint Conference on Diabetes Interdisciplinary Research Programs, Gaithersburg, MD

8 1997 Juvenile Diabetes Foundation International Fourth World Conference on Diabetes Research, Athens, Greece 1997 UAB Department of Neurobiology Retreat, Lay Lake-Columbiana 1997 8th Annual Vascular Biology and Hypertension Research Symposia, Destin, FL 1998 FASEB Summer Research Conference, Snowmass Village, CO 1998 Diabetic Complications Conference, Joslin Diabetes Center, Boston, MA 1997 NIDDK-JDFI Joint Conference on Diabetes Interdisciplinary Research Programs, Washington, DC 1998 NIDDK-JDFI Joint Conference on Diabetes Interdisciplinary Research Programs, Washington, DC 1999 American Diabetes Association Symposium on Diabetic Complications, San Diego, CA 2002 Experimental Biology 2002 Session Organizer, New Orleans, LA 2002 Hungarian Membrane-Transport Conference, Pécs University, Hungary – Declined 2003 Association of American Medical Colleges, The Regulation of Select Agents Research, Montreal, CA 2003 Experimental Biology 2003 Session Speaker, Recruiting, Educating and Mentoring the Experimental Biologists of the Future, San Diego, CA 2004 Experimental Biology 2004 Mini-Symposium Co-Organizer and Speaker, Washington, DC 2004 SHOCK Society Annual Meeting Speaker, Halifax, Nova Scotia 2004 Resuscitation Science Symposium (ReSS), New Orleans, LA 2006 Experimental Biology 2006 Invited Speaker

Administrative Presentations

1991 American Society for Cell Biology Representative to Hearings Before the House Appropriations Subcommittee Overseeing National Science Foundation Funding 2002 Association of American Medical Colleges, The Evolving Role of the Basic Science Department Chair, Philadelphia, PA 2003 University of Cincinnati Medical Center, Research Centers of Excellence 2003-2004 Alabama House of Representatives Subcommittee Dealing with Human Cloning 2003 Association of American Medical Colleges, The Regulation of Select Agents Research, Montreal, CA 2004 Association of American Medical Colleges, Group for Research Advancement and Development, Session Head, Life After NIH 2004 University of at Chicago College of Medicine, Allocation of Research Space 2005 Association of American Medical Colleges Group on Research Advancement and Development, Bridge Funding, Finding Money, Salt Lake City, UT 2006 Association of American Medical Colleges Group on Research Advancement and Development Annual Meeting, Surviving the Hard Landing: Seed, Bridges, and Transition, Arlington, VA 2006 Association of American Medical Colleges, Challenges Facing the Biomedical Research Enterprise 2006 American Association of Medical Colleges, Redefining Research Training, The NIH Hard Landing, Tucson, Arizona 2006 Association of American Medical Colleges, Executive Development Series, Issues in Research, Ft. Lauderdale, FL

9 2007 Association of American Medical Colleges, Executive Development Series, Current Issues in Research, Ft. Lauderdale, FL 2008 Association of Medical School Neuroscience Department Chairpersons, St. Croix, VI 2008 Association of American Medical Colleges, Executive Development Series, Current Issues in Research, Ft. Lauderdale, FL 2008 Harvard Medical School Symposium, Science and the Presidential Election, Boston, MA 2009 Association of American Medical Colleges, Executive Development Series, Current Issues in Research, Ft. Lauderdale, FL 2011 Association of Public and Land-grant Universities Annual Meeting, Denver

Reviewing Responsibilities

Standing Peer Review Panels:

National Science Foundation Developmental Biology Advisory Panel 1983-1987 Wakeman Award Selection Committee 1982-1986

Ad Hoc Grant Reviews:

National Cancer Institute Site Visitor National Science Foundation Division of Physiology, Cellular and Molecular Biology Developmental Neurosciences Developmental Biology International Programs Office of Naval Research Louisiana Education Quality Trust Fund National Research Council Howard Hughes Predoctoral Evaluation Panel National Institutes of Health/Cystic Fibrosis Foundation Medical Scientific Review Committee - Juvenile Diabetes Foundation International National Institutes of Health Diabetes Research Training Center Review National Institutes of Health Diabetes Interdisciplinary Research Programs American Association for the Advancement of Science – Foundation Reviews

Editorial Boards:

American Journal of Physiology: Cell Physiology, 1994-1999 The Anatomical Record (Associate Editor), 1998-2003 SHOCK, 2001-2007 Technology and Innovation, 2012-present

Ad Hoc Book or Article Reviews:

Developmental Biology, Differentiation, Science, Quarterly Review of Biology, Journal of Neurochemistry, Journal of Cell Biology, Endocrinology, Cell Motility and the Cytoskeleton, Journal of Biological Chemistry, Journal of Clinical Endocrinology and Metabolism, Pediatrics Research, Physiologia Plantarum, Holt-Rinehart-Winston, Addison-Wesley, Academic Press, Diabetologia, Diabetes, Journal of Immunology, Journal of Clinical Investigation, American Journal of Physiology: Endocrinology and Metabolism, Journal of Cellular Physiology, Glycobiology.

10 Patents

Glucose-6-Phosphate Uptake Inhibitors and Novel Uses Thereof, #5,643,883, Marchase, R.B. and Darbha, S. (1997).

U.S. Patent Application, Activators of Hexosamine Biosynthesis as Inhibitors of Injury Induced by Ischemia or Hemorrhagic Shock. Marchase, R. B., Bounelis, P., Chatham, J., Chaudry, I., and Pang, Y.

Public Service

1994-2004 BioTeach 1996-2002 Juvenile Diabetes Foundation Birmingham Chapter Board of Directors 1996 Juvenile Diabetes Foundation Atlanta Chapter, Presentation to St. Joseph’s Medical Center 1996-2000 Juvenile Diabetes Foundation Birmingham Chapter Government Relations Committee 1997-1999 Juvenile Diabetes Foundation Birmingham Chapter Patient Education/Family Support Committee 1999 Juvenile Diabetes Foundation Lecture, Buffalo, NY Chapter 2000 Juvenile Diabetes Foundation Lecture, Charleston, SC, Chapter 2000-2003 Juvenile Diabetes Foundation Birmingham Chapter Outreach Committee 2001 Juvenile Diabetes Research Foundation Lecture, Birmingham, AL Chapter 2001 Juvenile Diabetes Research Foundation Lecture, Dallas, Texas Chapter 2001 Juvenile Diabetes Research Foundation Lecture, Fund Raising Breakfast, Birmingham, AL 2002 Juvenile Diabetes Research Foundation Lecture, Amarillo, Texas Chapter 2002 Birmingham Innovation Group, St. Louis, Missouri 2006 Birmingham Innovation Group, Pittsburgh, PA 2006-present Board of Directors, The Innovation Depot 2006-present Board of Directors, Biotechnology Association of Alabama 2007-present Member, Rotary Club of Birmingham, Birmingham, AL 2007 Birmingham Innovation Group, Denver, CO 2008-2009 Board of Directors, Birmingham Metropolitan Development Board 2009-2011 Chair, Alabama EPSCoR Steering Committee 2009-2013 Board of Directors, Birmingham Business Alliance 2009-2011 Steering Committee, Science and Technology Roadmap for Alabama 2011-present Chair, Innovation Depot Board of Directors 2012-present Board of Directors, Economic Development Partnership Foundation of Alabama 2012-present Board of Directors, Triumph Services, Inc.

Research Publications and Book Chapters

1. Barbera, A.J., Marchase, R.B., and Roth, S. (1973) Adhesive Recognition and Retinotectal Specificity. Proc. Natl. Acad. Sci. USA 70:2482-2486.

2. Marchase, R.B., Barbera, A.J., and Roth, S. (1975) A Molecular Approach to Retinotectal Specificity. In: Cell Patterning, CIBA Foundation Symp. 29, Associated Scientific Publisher, Amsterdam. pp. 315-341.

11 3. Roth, S., Barbera, A.J., Shur, B.D., and Marchase, R.B. (1975) The Localization and Nature of Molecules Potentially Involved in Morphogenesis of the Developing Nervous System. In: Extracellular Matrix Influences on Gene Expression (H. Slavkin, ed.) Academic Press, Inc., New York. pp. 473-477.

4. Roth, S. and Marchase, R.B. (1976) An In Vitro Assay for Retinotectal Specificity. In: Neuronal Recognition. (S.H. Barondes, ed.) Plenum Press, New York. pp. 227-248.

5. Marchase, R.B. (1976) Ph.D. Thesis. The Johns Hopkins University. Investigations of Retinotectal Adhesive Specificity.

6. Marchase, R.B., Vosbeck, K., and Roth, S. (1976) Intercellular Adhesive Specificity. Biochem. Biophys. Acta 457:385-416.

7. Marchase, R.B. (1977) Biochemical Investigations of Retinotectal Adhesive Specificity. J. Cell Biol. 75:237-257.

8. Pierce, M., Shur, B.D., Marchase, R.B., and Roth, S. (1978) Glycosyltransferase Activities in Developing Chick Embryos: Potential Roles in Cell Recognition and Migration. In: The Molecular Basis of Cell-Cell Interaction. (R.A. Lerner and D. Bergsma, eds.) A.R. Liss, New York. pp. 317-326.

9. Marchase, R.B. and Roth, S. (1978) Properties of a Double Gradient Model for Retinotectal Specificity. In: Cell Surface Carbohydrates and Biological Recognition (V.T. Marchesi, V. Ginsburg, P.W. Robbins, and C.F. Fox, eds.), A.R. Liss, New York. pp. 637-645.

10. Jakoi, E.R. and Marchase, R.B. (1979) Ligatin from Embryonic Chick Neural Retina. J. Cell Biol. 80:642-650.

11. McClay, D.R. and Marchase, R.B. (1979) Isolation of Ectoderm and Endoderm from Sea Urchin Plutei and Demonstration of Germ Layer Specific Antigens. Develop. Biol. 71:289-296.

12. Marchase, R.B. and Jakoi, E.R. (1981) Ligatin from Neural Retina: Potential Baseplate for Retinal Cell Adhesion. In: Membranes, Molecules, Toxins, and Cells. (K. Bloch, L. Bolis, and D. Tosteson, eds.) PSG, Boston. pp. 214230.

13. Marchase, R.B. and Jakoi, E.R. (1981) Intercellular Adhesion Among Developing Retinal Cells: A Role for Ligatin as a Baseplate. In: Ocular Size and Shape During Development. (R. Hilfer and J. Sheffield, eds.), Springer Verlag, New York. pp. 123-129.

14. McClay, D.R., Wessel, G.M., and Marchase, R.B. (1981) Intercellular Recognition: Quantitation of Initial Binding Events. Proc. Natl. Acad. Sci. USA, 78:4975-4979.

15. Marchase, R.B., Harges, P., and Jakoi, E.R. (1981) Ligatin from Embryonic Chick Neural Retina Inhibits Retinal Cell Adhesion. Develop. Biol. 86:250-255.

16. Jakoi, E.R., Marchase, R.B., and Reedy, M.C. (1981) Distribution of Anionic Sites on Surfaces of Retinal Cells: A Study Using Cationized Ferritin. J. Ultrastruct. Res. 76:154-168.

17. Marchase, R.B., Koro, L.A., Kelley, C.M., and McClay, D.R. (1982) Retinal Ligatin Recognizes Glycoproteins Bearing Oligosaccharides Terminating in Phosphodiester Linked Glucose. Cell 28:813-820.

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18. Marchase, R.B. (1982) Cellular Adhesion. In: McGraw Hill Encyclopedia of Science and Technology, 5th edition. McGraw Hill, New York. pp. 741-744.

19. McClay, D.R. and Marchase, R.B. (1982) Calcium-dependent and Calcium-independent Adhesive Mechanisms are Present During Initial Binding Events of Neural Retina Cells. J. Cellular Biochem. 18:469-478.

20. Marchase, R.B., Koro, L.A., Kelly, C.M., and McClay, D.R. (1982) A Possible Role for Ligatin and the Phosphoglycoproteins: It Binds in Calcium Dependent Retinal Cell Adhesion. J. Cellular Biochem. 18:461-468.

21. Gaston, S.M., Marchase, R.B., and Jakoi, E.R. (1982) Brain Ligatin: A Membrane Lectin that Binds Acetylcholinesterase. J. Cellular Biochem. 18:447-460.

22. Koro, L.A. and Marchase, R.B. (1982) A UDP-Glucose: Glycoprotein Glucose-1- Phosphotransferase in Embryonic Chick Neural Retina. Cell 31:739-748.

23. McClay, D.R., Cannon, G.W., Wessel, G.M., Fink, R.D., and Marchase, R.B. (1983) Patterns of Antigenic Expression in Early Sea Urchin Development. In: Time, Space, and Pattern in Embryonic Development (W.R. Jeffrey and R.A. Raff, eds.). A.R. Liss, New York. pp. 157-169.

24. Wessel, G.M., Marchase, R.B., and McClay, D.R. (1984) Ontogeny of the Basement Membrane of the Sea Urchin Embryo. Develop. Biol. 103:235-245.

25. Marchase, R.B., Koro, L.A., and Hiller, A.M. (1984) Receptor for Glycoproteins with Phosphorylated Oligosaccharides. In: The Receptors 1:261-313. (P.M. Conn, ed.). Academic Press, New York.

26. Marchase, R.B. (1985) Phosphoglucose-Containing Glycoproteins in Intracellular Trafficking and Neural Recognition. In: Gene Expression and Cell-Cell Interaction in the Developing Nervous System (J. Lauder and P. Nelson, eds.) Plenum, New York. pp. 161-174.

27. Marchase, R.B. and Hiller, A.M. (1986) Glucose Phosphotransferase and Intracellular Trafficking. Molec. Cell. Biochem. 72:101-107.

28. Marchase, R.B. (1987) Receptors for Glycoproteins with Oligosaccharides Containing α- Glucose-1-Phosphate. In: Vertebrate Lectins (K. Olden and J.B. Parent, eds.). Van Nostrand Reinhold, New York. pp. 108-123.

29. Marchase, R.B. (1987) A Role for Glucose-1-Phosphate-Containing Glycoproteins in Intercellular Adhesion. Amer. Zool. 27:179-187.

30. Hiller, A.M., Koro, L.A., and Marchase, R.B. (1987) Glucose-1-Phosphotransferase and GlcNAc-1-Phosphotransferase Have Distinct Acceptor Specificities. J. Biol. Chem. 262:4377- 4381.

31. Humphreys-Beher, M.G., Schneyer, C.A., Kidd, V.J., and Marchase, R.B. (1987) Isoproterenol- Mediated Parotid Gland Hypertrophy Is Inhibited by Effectors of 4β-Galactosyltransferase. J. Biol. Chem. 262:11706-11713.

13 32. Marchase, R.B., Hiller, A.M., Rivera, A.A., and Cook, J.M. (1987) The (β35S) Phosphorothioate Analogue of UDP-Glc is Efficiently Utilized by the Glucose Phosphotransferase and is Resistant to Hydrolytic Degradation. Biochim. Biophys. Acta. 916:157-162.

33. Marchase, R.B., Kidd, V.J., Rivera, A.A., and Humphreys-Beher, M.G. (1988) Cell Surface Expression of 4β-Galactosyltransferase Accompanies Parotid Cell Transition to Growth. J. Cell Biochem. 36:453-465.

34. Srisomsap, C., Richardson, K.L., Jay, J.C., and Marchase, R.B. (1988) Localization of the Glucose Phosphotransferase to a Cytoplasmically Accessible Site on Intracellular Membranes. J. Biol. Chem. 263:17792-17797.

35. Srisomsap, C., Richardson, K.L., Jay, J.A., and Marchase, R.B. (1989) An αGlucose-1- Phosphate Phosphodiesterase is Present in Rat Liver Cytosol. J. Biol. Chem. 264:20540-20546.

36. Marchase, R.B., Richardson, K.L., Srisomsap, C., Drake, R.A., and Haley, B.E. (1990) Resolution of Phosphoglucomutase and the 62 kDa Acceptor for the Glucosylphosphotransferase. Archives Biochem. Biophys., 280:122-129.

37. Satir, B.H., Srisomsap, C., Reichman, M., and Marchase, R.B. (1990) Parafusin, An Exocytic- Sensitive Phosphoprotein, is the Primary Acceptor for the Glucosylphosphotransferase in Paramecium Tetraurelia and Rat Liver. J. Cell. Biol. 111:901-907.

38. Mullis, K.G., Haltiwanger, R.S., Hart, G.W., Marchase, R.B., and Engler, J.A. (1990) Relative Accessibility of N-Acetylglucosamine in Trimers of the AD2 and AD5 Fiber Protein. J. Virol. 64:5317-5323.

39. Marchase, R.B., Burkart, M.F., Rivera, A.A., Clarke, B.L., Shur, B.D., Overmeyer, G.D., and Shaw, R.D. (1991) β-phosphorothioate Analogues of Nucleotide Sugars Are Resistant to Hydrolytic Degradation and Utilized Efficiently by Glycosyltransferases. Analytical Biochemistry. 197:40-46.

40. Brumley, L.M. and Marchase, R.B. (1991) Receptor Synthesis and Routing to the Plasma Membrane. Am. J. Med. Sci. 302:238-243.

41. Sorscher, E.J., Fuller, C.M., Bridges, R.J., Tousson, A., Marchase, R.B., Brinkley, B.R., Frizzell, R.A., and Benos, D.J. (1992) Identification of a 60 kDa Membrane Protein from T-84 Cells Using Antibodies Made Against a Synthetic DIDS-Binding Peptide. Am. J. Physiol.: Cell Physiol. 262:C136-C147.

42. Zeller, C.B. and Marchase, R.B. (1992) Gangliosides as Modulators of Cell Function. Am. J. Physiol.: Cell Physiol. 262:C1341-C1355.

43. Prince, L.S., Tousson, A., and Marchase, R.B. (1993) Cell Surface Labeling of CFTR in T84 Cells. Am. J. Physiol.:Cell Physiol. 264:C491-C498.

44. Auger, D., Bounelis, P., and Marchase, R.B. (1993) Phosphoglucomutase Is a Cytoplasmic Glycoprotein Implicated in the Regulated Secretory Pathway. NATO ASI Series, Vol. H 74. In: Molecular Mechanisms of Membrane Traffic. (Morré, D.J., Bergeron, J.J.M., and Howell, K.M., eds.), Springer-Verlag, New York/Heidelberg, pp 289-292.

14 45. Marchase, R.B., Bounelis, P., Brumley, L.M., Dey, N., Browne, B., Auger, D., Fritz, T.A., Kulesza, P., and Bedwell, D.M. (1993) Phosphoglucomutase in Saccharomyces cerevisiae is a Cytoplasmic Glycoprotein and the Acceptor for a Glc-phosphotransferase. J. Biol. Chem. 268:8341-8349.

46. Lomako, J., Lomako, W.M., Kirkman, B.R., Whelan, W.J., and Marchase, R.B. (1993) Glycogen Contains Phosphodiester Groups Introduced by UDP-Glucose: Glycogen Glucose-1- Phosphotransferase. FEBS Letters. Vol. 329:3, 263-267.

47. Rivera, A.A., Elton, T.S., Dey, N.B., Bounelis, P., and Marchase, R.B. (1993) Isolation and Expression of a Rat Liver cDNA Encoding Phosphoglucomutase. Gene. 133:261-266.

48. Veyna, N.A., Jay, J.C., Srisomsap, C., Bounelis, P., and Marchase, R.B. (1994) The Addition of Glucose-1-Phosphate to the Cytoplasmic Glycoprotein Phosphoglucomutase is Modulated by Cytoplasmic Calcium in PC12 Cells and Rat Cortical Synaptosomes. J. Neurochem. 62:456- 464.

49. Montague, P. R., Gancayco, C.D., Winn, M.J., Marchase, R.B., and Friedlander, M.J. (1994) Mediation of NMDA receptor-Induced Neurotransmitter Release in the Cerebral Cortex by Nitric Oxide. Science. 263:973-977.

50. Prince, L.S., Workman, Jr., R.W., and Marchase, R.B. (1994) Rapid Endocytosis of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel. Proc. Natl. Acad. Sci. 91:5192-5196.

51. Dey, N.B., Bounelis, P., Fritz, T.A., Bedwell, D.M., and Marchase, R.B. (1994) The Glycosylation of Phosphoglucomutase is Modulated by Carbon Source and Heat Shock in Saccharomyces cerevisiae. J. Biol. Chem. 269:43, 27143-27148.

52. Fu, L., Bounelis, P., Dey, N., Browne, B.L., Marchase, R.B., and Bedwell, D.M. (1995) The Post-Translational Modification of Phosphoglucomutase is Regulated by Galactose Induction and Glucose Repression in Saccharomyces cerevisiae. J. Bacteriol. 177:3087-3094.

53. Rivera, A.A., White, C.R., Guest, L.L., Elton, T.S., and Marchase, R.B. (1995) Hyperglycemia Alters Cytoplasmic Ca2+ Responses to Capacitative Ca2+ Influx in Rat Aortic Smooth Muscle Cells. Am. J. Physiol.:Cell Physiol. 38:6, C1482-C1488.

54. Tsukamoto, H., Tousson, A., Marchase, R.B., and Volanakis, J.E. (1996) Down-Regulation of Secretion of Human Complement Component C2 by the Product of an Alternatively Spliced C2 Messenger RNA. J. Immunol. 156:4901-4908.

55. Darbha, S. and Marchase, R.B. (1996) Regulation of Intracellular Calcium is Closely Linked to Glucose Metabolism in J774 Macrophages. Cell Calcium 20:4, 361-371.

56. Newfield, R.S., Polak, M., Marchase, R.B., and Czernichow, P. (1997) Epidemiology and Genetics of Diabetic Complications. Diabetologia 40, 3:B62-64.

57. Polak, M., Newfield, R.S., Fioretto, P., Czernichow, P., and Marchase, R.B. (1997) Pathophysiology of Diabetic Complications. Diabetologia 40, 3:B65-67.

58. Chen, P.Y., Csutora, P., Veyna-Burke, N.A., and Marchase, R.B. (1998) Glc-6-Phosphate and Ca2+ are Mutually Enhanced in Microsomes from Liver, Brain, and Heart. Diabetes. 47: 874-881.

15 59. Csutora, P., Su, Z., Kim, H.Y., Bugrim, A., Cunningham, K.W., Nuccitelli, R., Keizer, J.E., Hanley, M.R., Blalock, J.E., and Marchase, R.B. (1999) Calcium Influx Factor Is Synthesized by Yeast and Mammalian Cells Depleted of Organellar Calcium Stores. PNAS 96:121-126.

60. Prince, L.S., Peter, K., Hatton, S.R., Zaliauskiene, L., Cotlin, L.F., Clancy, J.P., Marchase, R.B., and Collawn, J.F. (1999). Efficient Endocytosis of the Cystic Fibrosis Transmembrane Conductance Regulator Requires a Tyrosine-Based Signal. J. Biol. Chem. 274:3602-3609.

61. Vemuri, S., and Marchase, R.B. The Inhibition of Capacitative Calcium Entry Due to ATP Depletion but not Due to Glucosamine Is Reversed by Staurosporine. (1999) J. Biol. Chem. 274:20165-20170.

62. Fu, L., Miseta, A., Hunton, D., Marchase, R.B., and Bedwell, D.M. Loss of the Major Isoform of Phosphoglucomutase Results in Altered Calcium Homeostasis in Saccharomyces cerevisiae. (2000) J. Biol. Chem. 275:5431-5440.

63. Peng, J., Chen, P.Y., Marchase, R.B., and Prestwich, G.D. Preparation and Use of Photoactivatable Glucose-6-phosphate Analog. (2000) Bioorgan. Medic. Chem. Ltr. 10:535- 539.

64. Holmes, E.W., et al. Measuring Contributions to the Research Mission of Medical Schools. (2000) Acad. Med. 75:304-313.

65. Trepakova, E.S., Csutora, P., Hunton, D.L., Marchase, R.B., Cohen, R.A., and Bolotina, V.M. Calcium influx factor (CIF) Directly Activates Store-Operated Cation Channels in Vascular Smooth Muscle Cells. (2000) J. Biol. Chem. 275:26158-26163.

66. Su., Z., Csutora, P., Hunton, D., Shoemaker, R.L., Marchase, R.B., and Blalock, J.E. A Store- operated Non-selective Cation Channel in Lymphocytes is Activated Directly by Ca2+ Influx Factor (CIF) and Diacylglycerol. (2001) AJP: Cell 280(5): C1284-C1292.

67. Hunton, D.L., Lucchesi, P.A., Pang, Y., Dell’Italia, L.J., and Marchase, R.B. Capacitative Calcium Entry Contributes to NFAT Nuclear Translocation and Hypertrophy in Cardiomyocytes. 2002. J. Biol. Chem. 277:14266-14273.

68. Tsukamoto, H., Tousson, A., Circolo, A., Marchase, R.B., and Volanakis, J.E. Calnexin is Associated with and Induced by Overexpressed Human Complement Protein. (2002) The Anat. Rec. 267:7-16.

69. Pang, Y. and Marchase, R.B. Hyperglycemia Inhibits Capacitative Calcium Entry and Hypertrophy in Neonatal Cardiomyocytes. (2002) Diabetes. 51:3461-3467.

70. Su, Z., Barker, D.S., Csutora, P., Chang, T., Shoemaker, R.L., Marchase, R.B., and Blalock, J.E. Regulation of Ca2+ Release Activated Ca2+ Channels by INAD and Calcium Influx Factor. (2002) AJP:Cell. 284(2): C497-C505.

71. Hunton, D.L., Zou, L.Y., Pang, Y., and Marchase, R.B. Adult Rat Cardiomyocytes Exhibit Capacitative Calcium Entry. (2004) Am. J. Physiol. 286:H1124-H1132.

72. Pang, Y., Bounelis, P., Chatham, J.C., and Marchase, R.B. The Hexosamine Pathway Is Responsible for the Inhibition by Diabetes of Phenylephrine-Induced Inotropy. (2004) Diabetes. 53:1074-1081. 16

73. Su, Z., Shoemaker, R.L., Marchase, R.B., and Blalock, J.E. Ca2+ Modulation of Ca2+ Release Activated-Ca2+ is Responsible for the Inactivation of its Monovalent Cation Current. (2004) Biophys. J. 86:805-814.

74. Kneass, Z., and Marchase, R.B. Neutrophils Exhibit Rapid Agonist-Induced Increases in Protein-Associated O-GlcNAc. (2004) J. Biol. Chem. 279:45759–45765.

75. Su, Zhengchang, Guo, Xiaochuan, Barker, D.S., Shoemaker, R.L., Marchase, R.B., and Blalock, J.E. A Store-Operated Nonselective Cation Channel in Human Lymphocytes. (2004) Cell. And Mol. Neurobiol. 25:625-647.

76. Kneass, Z. and Marchase, R.B. Protein O-GlcNAc Modulates Motility-associated Signaling Intermediates in Neutrophils. (2005) J. Biol. Chem. 280:14579-14585.

77. Nagy T., Champattanachai V., Marchase R.B. and Chatham J.C. Glucosamine Inhibits Angiotensin II Induced Cytoplasmic Ca2+ Elevation in Neonatal Cardiomyocytes via Protein- associated O-GlcNAc (2006) Am. J. Physiol:Cell Physi. 290:C57-C65.

78. Liu J., Pang Y., Chang T., Bounelis P., Chatham J.C. and Marchase R.B. Increased Hexosamine Biosynthesis and Protein O-GlcNAc Levels Associated with Myocardial Protection Against Calcium Paradox and Ischemia. (2006) J. Mol. Cell. Cardiol. 40:303-312.

79. Yang S., Zou, L.-Y., Bounelis P., Chaudry I., Chatham J.C. & Marchase R.B. Glucosamine Administration During Resuscitation Improves Organ Function Following Trauma-hemorrhage. (2006) Shock 25: 600-607.

80. Fülöp N., Marchase R.B., and Chatham J.C.. Role of Protein O-linked N-acetyl-glucosamine in Mediating Cell Function and Survival in the Cardiovascular System. (2007) Cardiovasc. Res. 73:288-297.

81. Nagy T, Champattanachai V, Marchase RB and Chatham JC. Glucosamine inhibits angiotensin II induced cytoplasmic Ca2+ elevation in neonatal cardiomyocytes via protein-associated O- GlcNAc. Am. J. Physiol. - Cell Physiol. 290: C57-C65, 2006.

82. Liu J, Pang Y, Chang T, Bounelis P, Chatham JC and Marchase RB. Increased hexosamine biosynthesis and protein O-GlcNAc levels associated with myocardial protection against calcium paradox and ischemia J. Mol. Cell. Cardiol. 40:303-312, 2006.

83. Yang S, Zou, L-Y, Bounelis P, Chaudry I, Chatham JC and Marchase RB. Glucosamine administration during resuscitation improves organ function following trauma-hemorrhage. Shock 25: 600-607, 2006.

84. Champattanachai V, Marchase RB and Chatham JC. Increased Flux through the hexosamine biosynthesis pathway protects cardiomyocytes from ischemia-reperfusion injury. Am. J. Physiol. Cell Physiol. 292: C178-C187 2007.

85. Fülöp N, Marchase RB and Chatham JC. Role of protein O-linked N-acetyl-glucosamine in mediating cell function and survival in the cardiovascular system. Cardiovasc. Res. 73: 288- 297, 2007.

17 86. Liu J, Marchase RB and Chatham JC. Glutamine-induced protection of isolated rat heart from ischemia/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levels. J. Mol. Cell. Cardiol. 42: 177-185, 2007.

87. Zou, L-Y, Yang S, Chaudry I, Marchase RB and Chatham JC. PUGNAc administration during resuscitation improves organ function following trauma-hemorrhage Shock 27: 402-408, 2007.

88. Fülöp N, Mason MM, Dutta K, Wang P, Davidoff AJ, Marchase RB and Chatham JC. The impact of diabetes and age on cardiomyocyte function and O-Linked N-acetylglucosamine levels in the heart. Am. J. Physiol. - Cell Physiol. 292: C1370-C1378, 2007.

89. Fülöp N, Zhang Z, Marchase RB and Chatham JC. Glucosamine cardioprotection in perfused rat heart associated with increased O-Linked N-acetylglucosamine protein modification and altered p38 activation. Am. J. Physiol. - Heart Circ Physiol 292: H2227-H2236, 2007.

90. Nöt LG, Marchase RB, Fülöp N, Brocks CA and Chatham JC. Glucosamine administration improves survival rate after severe hemorrhagic shock combined with trauma in rats. Shock. 28: 345-352, 2007.

91. Liu J, Marchase RB and Chatham JC. Increased O-GlcNAc levels during reperfusion lead to improved functional recovery and reduced calpain proteolysis. Am. J. Physiol. Heart Circ. Physiol. 293: H1391-399, 2007.

92. Champattanachai V, Marchase RB, Chatham JC. Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein O-GlcNAc and increased mitochondrial Bcl-2. Am. J. Physiol. Cell Physiol. 294: C1509-1520, 2008.

93. Fülöp N, Feng W, Xing D, He K, Not LG, Brocks CA, Marchase RB, Miller AP, Chatham JC. Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway rats. Biogerontology, 139-151, 2008.

94. Shan D, Marchase RB, Chatham JC. Overexpression of TRPC3 increases apoptosis but not necrosis in response to ischemia-reperfusion in adult mouse cardiomyocytes. Am. J. Physiol:Cell Physiol. C833-841, 2008.

95. Chatham JC, Nöt LG, Fülöp N, Marchase RB. Hexosamine biosynthesis and protein O- glycosylation: the first line of defense against stress, ischemia, and trauma. Shock 29: 431-440, 2008.

96. Zou L, Yang S, Champattanachai V, Hu S, Chaudry IH, Marchase RB, Chatham JC Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O- GlcNAcylation and attenuation of NF-{kappa}B signaling. Am J Physiol Heart Circ Physiol. 296: H515-523, 2009.

97. Teitelbaum SL and Marchase RB. The outlook for biomedical research under the Barack Obama administration. IBMS BoneKEy. 6:5-7. 2009.

98. Chatham, J.C. and Marchase, R.B. The role of protein O-linked beta-N-acetylglucosamine in mediating cardiac stress responses. Biochim Biophys Acta. 1800:57-66, 2010.

99. Chatham JC and Marchase RB. Protein O-GlcNAcylation: A critical regulator of the cellular response to stress. Curr Signal Transduct Ther. 5: 49–59, 2010.

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100. Not, L., Brooks, C., Vamhidy, L., Marchase, R.B., Chatham, J. Increased O-linked β-N- acetylglucosamine levels on proteins improves survival, reduces inflammation and organ damage 24 hours after trauma-hemorrhage in rats. Critical Care Med. 38:2 562-571, 2010.

101. Zhu-Mauldin X., Marsh S.A., Zou L., Marchase R.B., and Chatham JC. Modification of STIM1 by O-linked N-acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytes. J Biol Chem. 287: 39094-39196, 2012.

102. Zou, L., Zhu-Mauldin X., Marchase, R.B., Paterson, A.J., Liu, J., Yang, Q., and Chatham, J.C. Glucose Deprivation-induced Increase in Protein O-GlcNAcylation in Cardiomyotyes Is Calcium- dependent. J Biol Chem. 287:34419-31, 2012.

103. Collins HE, Zhu-Mauldin X, Marchase RB, and Chatham JC. STIM1/Orai1-mediated SOCE: current perspectives and potential roles in cardiac function and pathology. Am J Physiol Heart Circ Physiol. 305:H446-58, 2013.

104. Taylor E.W., Wang K., Nelson A.R., Bredemann T.M., Fraser K.B., Clinton S.M., Puckett R, Marchase R.B., Chatham J.C., McMahon L.L. O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses. J Neurosci. 34:10-21, 2014.

105. Sanberg, P.R., Gharib, M., Harker, P.T., Kaler, E.W., Marchase, R.B., Sands, T.D., Arshadi, N., Sarkar, S. Changing the academic culture: Valuing patents and commercialization to toward tenure and career advancement. Proc Natl Acad Sci USA. 10.1073/pnas.1404094111, 2014.

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