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Document Details Scopus Document details ◅ Back to results 1 of 1 Metrics View all metrics ▻ Export Download Print E-mail Save to PDF ⋆ Add to List More... ▻ View at Publisher 7 Citations in Scopus 30th percentile Journal of Ethnopharmacology 0.40 Field-Weighted Volume 173, 30 July 2015, Pages 166-171 Citation Impact Evaluation of anti-inflammatory activity of the methanolic extract from Jungia rugosa leaves in rodents (Article) Wilches, I.a, Tobar, V.b, Peñaherrera, E.a, Cuzco, N.a, Jerves, L.a, Vander Heyden, Y.c, León-Tamariz, F.a, Vila, E.a,d a Faculty of Chemistry, School of Biochemistry and Pharmacy, University of Cuenca, Cuenca, Ecuador PlumX Metrics bFaculty of Engineering, University of Cuenca, Cuenca, Ecuador Usage, Captures, Mentions, cDepartment Analytical Chemistry and Pharmaceutical Technology, Vrije Universiteit Brussels-VUB, Belgium Social Media and Citations View additional affiliations beyond Scopus. Abstract View references (37) Ethnopharmacological relevance: Jungia rugosa Less (Asteraceae), popularly known in Ecuador as "Carne Cited by 7 documents humana" or "Fompo", is a vine present into the Andean region. It is traditionally used as medicine for the treatment of A novel mPGES-1 inhibitor bruises, cuts and other external inflammatory processes. This study was designed to investigate the anti-inflammatory alleviates inflammatory responses activity of J. rugosa leaves extract (JRLE) in rodents . Material and methods: The acute anti-inflammatory by downregulating PGE2 in activity was evaluated by animal models, including croton oil-induced ear oedema in mice, carrageenan-induced experimental models paw oedema in rats and myeloperoxidase (MPO); the chronic anti-inflammatory activity was evaluated by cotton Lee, H.-H. , Moon, Y. , Shin, J.-S. pellet-induced granuloma. Results: Intraperitoneal administration of JRLE (125, 250, 500 mg/kg) significantly (p<0.01- (2019) Prostaglandins and Other 0.001) inhibited the croton oil-induced ear oedema and MPO activity in mice; the carrageenan-induced paw Lipid Mediators oedema in rats was significantly (p<0.05) reduced by 500 mg/kg. Repeated (6 days) administration of the extract to Anti-edematogenic and anti- mice previously implanted with cotton pellets reduced the formed granuloma (125 mg/kg: 11.7%; 250 mg/kg: 17.9%; granuloma activity of a synthetic 500 mg/kg: 32.4%) but only the inhibition by 500 mg/kg reached statistical significance (p<0.01). Conclusions: The curcuminoid analog, 5-(3,4- results show that JRLE is effective as an anti-inflammatory agent in acute and chronic inflammation in mice, dihydroxyphen... in mouse supporting its traditional use. © 2015 Elsevier Ireland Ltd. All rights reserved. models of inflammation Hisamuddin, N. , Shaik Mossadeq, W.M. , Sulaiman, SciVal Topic Prominence M.R. (2019) Molecules Topic: Hungary | Nutrition Surveys | Dietary habits Hypoglycemic activity of jungia Prominence percentile: 42.201 rugosa less on induced diabetic mice (mus musculus) Acosta León, K.L. , Tacuamán Chemistry database information Jácome, S.E. , Vinueza Tapia, D.R. (2019) Pharmacologyonline Substances View all 7 citing documents ⤢ ⤢ Inform me when this document O Cl is cited in Scopus: Tween 20 N CH 3 H 3 C O O Set citation alert ▻ OH Set citation feed ▻ Author keywords Inflammation Jungia rugosa Mice Pharmacodynamics Traditional medicine Meso-Southern America Related documents In vivo anti-inflammatory effects Indexed keywords of taraxasterol against animal models Wang, Y. , Li, G.-H. , Liu, X.-Y. (2017) African Journal of Traditional, Complementary and Alternative Medicines Anti-inflammatory activity of EMTREE drug terms: antiinflammatory agent carrageenan croton oil indometacin rhein isolated from the flowers of Jungia rugosa leaves extract methanol myeloperoxidase plant extract Cassia fistula L. and possible underlying mechanisms unclassified drug antiinflammatory agent croton oil methanol peroxidase Antonisamy, P. , Agastian, P. , plant extract solvent Kang, C.-W. (2019) Saudi Journal of Biological Sciences EMTREE medical animal experiment antiinflammatory activity area under the curve Article Asteraceae terms: carrageenan-induced paw edema controlled study cotton cotton pellet-induced granuloma Hypoglycemic activity of jungia rugosa less on induced diabetic drug efficacy drug inhibition ear edema enzyme activity Jungia rugosa mice (mus musculus) low drug dose male medicinal plant mouse nonhuman plant leaf Acosta León, K.L. , Tacuamán plant structures rat rodent single drug dose animal chemically induced Jácome, S.E. , Vinueza Tapia, D.R. (2019) Pharmacologyonline chemistry disease model drug effects edema Granuloma, Foreign-Body metabolism neutrophil plant leaf Wistar rat View all related documents based on references Species Index: Animalia Asteraceae Gossypium hirsutum Jungia Mus Rattus Rodentia Find more related documents in Scopus based on: Authors ▻ Keywords ▻ MeSH: Animals Anti-Inflammatory Agents Asteraceae Carrageenan Cotton Fiber Croton Oil Disease Models, Animal Edema Granuloma, Foreign-Body Male Methanol Mice Neutrophils Peroxidase Plant Extracts Plant Leaves Rats, Wistar Solvents Chemicals and CAS Registry Numbers: carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; croton oil, 8001-28-3; indometacin, 53-86-1, 74252-25-8, 7681-54-1; methanol, 67-56-1; myeloperoxidase; peroxidase, 9003-99-0; Anti-Inflammatory Agents; Carrageenan; Croton Oil; Methanol; Peroxidase; Plant Extracts; Solvents Funding details Funding sponsor Funding number Acronym ZIUS2014AP2015,21203006301410 Dirección de Investigación, Universidad Austral de Chile Funding text This work was funded by the Dirección de Investigación de la Universidad de Cuenca (DIUC, 21203006301410) VLIR- UOS (ZIUS2014AP2015) project “Pharmacological Characterisation of Medicinal Plants from the South of Ecuador”. Elisabet Vila was supported by Proyecto Prometeo, Secretaria de Educación Superior, Ciencia, Tecnología e Innovación de la República del Ecuador . We thank Priscila Jiménez for technical assistance. ISSN: 03788741 DOI: 10.1016/j.jep.2015.07.004 CODEN: JOETD PubMed ID: 26192806 Source Type: Journal Document Type: Article Original language: English Publisher: Elsevier Ireland Ltd References (37) View in search results format ▻ All Export Print E-mail Save to PDF Create bibliography 1 Adeneye, A.A., Adeyemi, O.O., Agbaje, E.O., Banjo, A.A.F. Evaluation of the toxicity and reversibility profile of the aqueous seed extract of hunteria umbellata (k. schum.) hallier f. in rodents (2010) African Journal of Traditional, Complementary and Alternative Medicines, 7 (4), pp. 350-369. Cited 9 times. http://www.bioline.org.br/pdf?tc10049 View at Publisher 2 Antonisamy, P., Duraipandiyan, V., Ignacimuthu, S. 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Cited 24 times. doi: 10.1016/j.jep.2010.05.001 View at Publisher 5 Otuki, M.F., Cabrini, D.A., Moresco, H.H., Imazu, P., Silva, C.D.D., Pietrovski, E.F., Mendes, D.A.G.B., (...), Brighente, I.M.C. Analysis of the potential topical anti-inflammatory activity of Averrhoa carambola L. in mice (Open Access) (2011) Evidence-based Complementary and Alternative Medicine, 2011, art. no. 908059. Cited 32 times. doi: 10.1093/ecam/neq026 View at Publisher 6 Cai, C., Chen, Y., Zhong, S., Ji, B., Wang, J., Bai, X., Shi, G. Anti-inflammatory activity of N-butanol extract from Ipomoea stolonifera in vivo and in vitro (Open Access) (2014) PLoS ONE, 9 (4), art. no. e95931. Cited 25 times. http://www.plosone.org/article/fetchObject.action? uri=info%3Adoi%2F10.1371%2Fjournal.pone.0095931&representation=PDF doi: 10.1371/journal.pone.0095931 View at Publisher 7 Carol, S.A. Acute, subchronic and chronic toxicology (1995) CRC Handbook of Toxicology, pp. 51-104. Cited 54 times. J.D. Michael, A.H. Mannfred (Eds.), CRC Press Boca Raton, FL, USA 8 Casado, R., Landa, A., Calvo, J.J., Del Carmen Terencio, M., Calvo, M.I. Anti-inflammatory and antioxidant activities of Jungia paniculata (2010) Pharmaceutical Biology, 48 (8), pp. 897-905. Cited 4 times. doi: 10.3109/13880200903311128 View at Publisher 9 Cuman, R.K.N., Bersani-Amado, C.A., Fortes, Z.B. Influence of type 2 diabetes on the inflammatory response in rats (2001) Inflammation Research, 50 (9), pp. 460-465. Cited 53 times. http://www.springerlink.com/content/1023-3830 doi: 10.1007/PL00000271 View at Publisher 10 CRUNKHORN, P., MEACOCK, S.C.R. Mediators of the inflammation induced in the rat paw by carrageenin (1971) British Journal of Pharmacology, 42 (3), pp. 392-402. Cited 280 times. doi: 10.1111/j.1476-5381.1971.tb07124.x View at Publisher 11 De Cássia Da Silveira E Sá, R., Andrade, L.N., De Sousa, D.P. A review on anti-inflammatory activity of monoterpenes (Open Access) (2013) Molecules, 18 (1), pp. 1227-1254. Cited 138 times. www.mdpi.com/1420-3049/18/1/1227/pdf doi: 10.3390/molecules18011227 View at Publisher 12 Gonzales De La Cruz, M., Baldeón Malpartida, S., Beltrán Santiago, H., Jullian, V., Bourdy, G. Hot and cold: Medicinal plant uses in Quechua speaking communities in the high Andes (Callejón de Huaylas, Ancash, Perú) (2014) Journal of Ethnopharmacology, 155 (2), pp. 1093-1117. Cited 32 times. www.elsevier.com/locate/jethpharm doi: 10.1016/j.jep.2014.06.042 View at Publisher 13 de las Heras, B., Rodríguez, B., Boscá, L., Villar, A.M. Terpenoids: sources, structure elucidation and therapeutic potential in inflammation. (2003) Current topics in medicinal chemistry, 3 (2), pp. 171-185. Cited 42 times.
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