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7Th Annual Kinase Inhibitor Chemistry Cover ELEVENTH ANNUAL Conference-at-a-Glance Welcome Letter Short Courses Drug Discovery Distinguished Faculty Inflammation Inhibitors Protein-Protein Interactions ChemistryAPRIL 19 - 22, 2016 HILTON SAN DIEGO RESORT & SPA | SAN DIEGO, CA Epigenetic Inhibitor Discovery Kinase Inhibitor Chemistry OPTIMIZING SMALL MOLECULES April 19 - 20 Macrocylics & Constrained FOR TOMORROW’S THERAPEUTICS Peptides Inflammation Inhibitors Fragment-Based Drug Discovery PLENARY KEYNOTES Protein-Protein Interactions Brain Penetrant Inhibitors A Chemist’s Foray into Translational Research Biophysical Approaches for Epigenetic Inhibitor Discovery Drug Discovery Peter G. Schultz, Ph.D., The Scripps Research Institute Antivirals: Small Molecule April 20 - 21 Inhibitors of Viral Targets Cell-Penetrating Miniproteins Applying Pharmacology to Gregory L. Verdine, Ph.D., New Drug Discovery Harvard University Kinase Inhibitor Chemistry Sponsor & Exhibit Opportunities Macrocyclics & Constrained Peptides Hotel & Travel Information EVENT FEATURES • More than 125 presentations Fragment-Based Drug Discovery Registration Information • 600+ high-level participants • 70+ posters Click Here to • Interactive roundtable, breakout SYMPOSIA Friday, April 22 Register Online! & panel discussions DrugDiscoveryChemistry.com • “Track-hop” between concurrent meetings Brain Penetrant Inhibitors • Exclusive exhibit & poster viewing hours • Dedicated networking opportunities Biophysical Approaches for Drug Discovery FINAL DAYS • 10 interactive short courses TO REGISTER! Antivirals: Small Molecule Inhibitors of Viral Targets There is Still time to join the largest PREMIER SPONSOR Drug Discovery Chemistry event ever Applying Pharmacology to New Drug Discovery Cambridge Healthtech Institute, 250 First Avenue, Suite 300, Cambridge Healthtech Needham, MA 02494 www.healthtech.com Cover -AT-A- PLENARY KEYNOTES Conference-at-a-Glance CONFERENCE GLANCE Tuesday, April 19 - 4:30 pm MONDAY, APRIL 18 PRE-CONFERENCE SHORT COURSES* Welcome Letter A Chemist’s Foray into INFLAMMATION INHIBITORS PROTEIN-PROTEIN EPIGENETIC INHIBITOR Translational Research Short Courses INTERACTIONS DISCOVERY Peter G. Schultz, Ph.D., Professor, Department of Chemistry, The Distinguished Faculty TUESDAY, Scripps Research Institute and APRIL 19 Director, California Institute for Biomedical Research Inflammation Inhibitors Combined Plenary Keynote Session Our research program Protein-Protein Interactions Welcome Reception in the Exhibit Hall with Poster Viewing combines the tools and principles of chemistry Epigenetic Inhibitor Discovery Continental Breakfast & Breakout Discussions with the molecules and INFLAMMATION INHIBITORS PROTEIN-PROTEIN EPIGENETIC INHIBITOR processes of living cells Kinase Inhibitor Chemistry INTERACTIONS DISCOVERY to synthesize new WEDNESDAY, molecules and molecular assemblies Macrocylics & Constrained APRIL 20 KINASE INHIBITOR MACROCYCLICS AND FRAGMENT-BASED DRUG with novel physical, chemical and Peptides CHEMISTRY CONSTRAINED PEPTIDES DISCOVERY biological functions. By studying the Breakout Discussions structure and function of the Fragment-Based Drug Dinner Short Courses* resulting molecules, new insights Discovery Combined Plenary Keynote Session can be gained into the mechanisms of complex biological and KINASE INHIBITOR MACROCYCLICS AND FRAGMENT-BASED DRUG Brain Penetrant Inhibitors CHEMISTRY CONSTRAINED PEPTIDES DISCOVERY chemical systems. THURSDAY, Thursday, April 21 - 8:30 am Biophysical Approaches for APRIL 21 Drug Discovery Cell-Penetrating Miniproteins Gregory L. Verdine, Ph.D., Professor, Antivirals: Small Molecule Departments of Stem Cell and Inhibitors of Viral Targets Regenerative Biology, Chemistry Symposium 1: Brain Penetrant Inhibitors and Chemical Biology, and Applying Pharmacology to Molecular and Cellular Biology, New Drug Discovery Harvard University Symposium 2: Biophysical Approaches for Drug Discovery Sponsor & Exhibit FRIDAY, It has been estimated APRIL 22 Opportunities Symposium 3: Antivirals: Small Molecule Inhibitors of Viral Targets that as few as 10-15% of all potential targets are Hotel & Travel Information Training Seminar: Applying Pharmacology to New Drug Discovery targetable in vivo by either biological or small Registration Information *Separate registration is required molecules. To address this deficiency, we and FOG Pharmaceuticals are developing Click Here to TRACK-HOPPING Attendees at Drug Discovery Chemistry are encouraged to cell-penetrating mini-proteins, “track-hop” between concurrent conference tracks. molecules that combine the ability Register Online! of proteins to target large flat DrugDiscoveryChemistry.com Though you register for a particular conference(s) or symposium, in reality you gain access surfaces, with the ability of small to all concurrent meeting or symposia tracks. For the best value, register for a conference molecules to penetrate cells. in each half of the event and a symposium, and gain access to all nine conference/symposia Progress on the development of FINAL DAYS tracks to customize four days of presentation programming that best fits your research cell-penetrating mini-proteins will TO REGISTER! needs. Add some pre-conference short courses and spend the week in San Diego! be reviewed in this talk. There is Still time to join the largest Drug Discovery Chemistry PREMIER SPONSOR CORPORATE SPONSORS CORPORATE SUPPORT SPONSORS event ever Cambridge Healthtech Institute, 250 First Avenue, Suite 300, Needham, MA 02494 www.healthtech.com Cover Conference-at-a-Glance WELCOME TO DRUG DISCOVERY CHEMISTRY Welcome Letter Cambridge Healthtech Institute’s Drug Discovery groups as part of each meeting track and two Plenary Short Courses Chemistry, now in its 11th year, has established itself as Keynote sessions where participants across the concurrent a leading conference for medicinal chemists working in meetings come together to hear a renowned scientist Distinguished Faculty pharma and biotech. The event focuses on discovery and discuss pioneering work of interest to all discovery chemists Inflammation Inhibitors optimization challenges of small molecule drug candidates, and biologists. More information on our Plenary Keynotes Protein-Protein Interactions and offers many exciting opportunities for scientists to move can be found on page 2. In addition, we have dedicated between concurrent conference tracks to create a unique and robust poster sessions in an exhibit hall that features Epigenetic Inhibitor Discovery program according to personal interests. cutting-edge chemistry, technologies, and services. Kinase Inhibitor Chemistry New this year are Symposia on the last day of the We also offer more than ten pre-conference and dinner Macrocylics & Constrained event. The three symposia are: Brain Penetrant Inhibitors, short courses which are designed to be instructional and Peptides Biophysical Approaches for Drug Discovery, and Antivirals. interactive. The short courses aim to introduce researchers Fragment-Based Drug Discovery The symposia represent areas of drug discovery with to a particular discipline and to serve as a refresher for recent upticks in their pace of progress which nicely those familiar with the topic, but who want to brush-up Brain Penetrant Inhibitors complement the event’s established conference tracks. on the most current advances. They also serve as an opportunity for the attendees to meet and ask questions of Biophysical Approaches for The 2016 conference tracks remain, due to last year’s Drug Discovery instructors and peers in a small group setting. record attendance and overwhelming positive delegate Antivirals: Small Molecule Inhibitors of Viral Targets feedback: Inflammation Inhibitors, Protein-Protein We invite you to review this brochure to see how our Interactions, and Epigenetic Inhibitor Discovery as the first great roster of speakers and synergistic topics blend to Applying Pharmacology to New Drug Discovery set of concurrent meetings. The second set of conference create the leading event in drug discovery chemistry where tracks include: Kinase Inhibitor Chemistry, Macrocyclics & scientists from all levels and settings can enjoy networking Sponsor & Exhibit Opportunities Constrained Peptides, and Fragment-Based Drug Discovery. and spontaneous face-to-face interactions with one another. We look forward to meeting you in San Diego! Hotel & Travel Information Event highlights include roundtable breakout discussion Registration Information Anjani Shah, Ph.D. Kip Harry Carolyn Benton Click Here to Conference Director and Conference Director Business Development Manager Register Online! Lead Director for Drug Discovery [email protected] [email protected] Chemistry DrugDiscoveryChemistry.com [email protected] FINAL DAYS TO REGISTER! There is Still time to join the largest Drug Discovery Chemistry event ever Cambridge Healthtech Institute, 250 First Avenue, Suite 300, Needham, MA 02494 www.healthtech.com Cover SHORT COURSES Separate registration is required Conference-at-a-Glance Welcome Letter MONDAY APRIL 18, 2016 SC5: Phenotypic Screening and Chemical WEDNESDAY APRIL 20, 2016 Probe Development Short Courses MORNING COURSES | 10:00 AM – 1:00 PM Instructor: Samarjit Patnaik, Ph.D., Research Scientist, DINNER COURSES | 6:30 – 9:00 PM Probe Development Center, NCATS, NIH SC1: Trends in Physical Properties of Drugs SC10: Enabling Macrocyclic Compounds for • Overview of modern phenotypic drug discovery Distinguished Faculty Instructors: Terry Stouch, Ph.D., President, R&D, Drug Discovery: Opportunities,
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