Total Avone of Abelmoschus Manihot Improves Colitis by Promoting
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Gastrointestinal Status and Microbiota Shaping in Amyotrophic Lateral Sclerosis: a New Frontier for Targeting?
8 Gastrointestinal Status and Microbiota Shaping in Amyotrophic Lateral Sclerosis: A New Frontier for Targeting? Letizia Mazzini1 • Fabiola De Marchi1 • Elena Niccolai2 • Jessica Mandrioli3, Amedeo Amedei2 1ALS Centre, Department of Neurology, Maggiore della Carità Hospital, University of Piemonte Orientale, Novara, Italy; 2Department of Experimental and clinical Medicine, University of Florence, Firenze, Italy; 3Department of Biomedical, Metabolic and Neural Science, University of Modena and Reggio Emilia, Modena, Italy Author for correspondence: Letizia Mazzini, ALS Centre, Department of Neurology, Maggiore della Carità Hospital, University of Piemonte Orientale, Novara, Italy. Email: [email protected] Doi: https://doi.org/10.36255/exonpublications.amyotrophiclateralsclerosis. microbiota.2021 Abstract: Amyotrophic lateral sclerosis (ALS) is a rare and severe neurodegenera- tive disease affecting the upper and lower motor neurons, causing diffuse muscle paralysis. Etiology and pathogenesis remain largely unclear, but several environ- mental, genetic, and molecular factors are thought to be involved in the disease process. Emerging data identify a relationship between gut microbiota dysbiosis and neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, and ALS. In these disorders, neuroinflammation is being increasingly recognized as a driver for disease onset and progression. Gut bacteria play a crucial role in In: Amyotrophic Lateral Sclerosis. Araki T (Editor), Exon Publications, Brisbane, Australia. ISBN: -
The Metabolites of the Dietary Flavonoid Quercetin Possess Potent Antithrombotic Activity, and Interact with Aspirin to Enhance Antiplatelet Effects
The metabolites of the dietary flavonoid quercetin possess potent antithrombotic activity, and interact with aspirin to enhance antiplatelet effects Article Published Version Creative Commons: Attribution 4.0 (CC-BY) Open Access Stainer, A. R., Sasikumar, P., Bye, A. P., Unsworth, A. P., Holbrook, L. M., Tindall, M., Lovegrove, J. A. and Gibbins, J. M. (2019) The metabolites of the dietary flavonoid quercetin possess potent antithrombotic activity, and interact with aspirin to enhance antiplatelet effects. TH Open, 3 (3). e244- e258. ISSN 2512-9465 doi: https://doi.org/10.1055/s-0039- 1694028 Available at http://centaur.reading.ac.uk/85495/ It is advisable to refer to the publisher’s version if you intend to cite from the work. See Guidance on citing . To link to this article DOI: http://dx.doi.org/10.1055/s-0039-1694028 Publisher: Thieme All outputs in CentAUR are protected by Intellectual Property Rights law, including copyright law. Copyright and IPR is retained by the creators or other copyright holders. Terms and conditions for use of this material are defined in the End User Agreement . www.reading.ac.uk/centaur CentAUR Central Archive at the University of Reading Reading’s research outputs online Published online: 30.07.2019 THIEME e244 Original Article The Metabolites of the Dietary Flavonoid Quercetin Possess Potent Antithrombotic Activity, and Interact with Aspirin to Enhance Antiplatelet Effects Alexander R. Stainer1 Parvathy Sasikumar1,2 Alexander P. Bye1 Amanda J. Unsworth1,3 Lisa M. Holbrook1,4 Marcus Tindall5 Julie A. Lovegrove6 Jonathan M. Gibbins1 1 Institute for Cardiovascular and Metabolic Research, School of Address for correspondence Jonathan M. -
Diversity in the Extracellular Vesicle-Derived Microbiome of Tissues According to Tumor Progression in Pancreatic Cancer
cancers Article Diversity in the Extracellular Vesicle-Derived Microbiome of Tissues According to Tumor Progression in Pancreatic Cancer Jin-Yong Jeong 1, Tae-Bum Kim 2 , Jinju Kim 1, Hwi Wan Choi 1, Eo Jin Kim 1, Hyun Ju Yoo 1 , Song Lee 3, Hye Ryeong Jun 3, Wonbeak Yoo 4 , Seokho Kim 5, Song Cheol Kim 3,6,* and Eunsung Jun 1,3,* 1 Department of Convergence Medicine, Asan Institute for Life Sciences, University of Ulsan College of Medicine and Asan Medical Center, Seoul 05505, Korea; [email protected] (J.-Y.J.); [email protected] (J.K.); [email protected] (H.W.C.); [email protected] (E.J.K.); [email protected] (H.J.Y.) 2 Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea; [email protected] 3 Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea; [email protected] (S.L.); [email protected] (H.R.J.) 4 Environmental Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea; [email protected] 5 Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, Korea; [email protected] 6 Biomedical Engineering Research Center, Asan Institute of Life Science, AMIST, Asan Medical Center, Seoul 05505, Korea * Correspondence: [email protected] (S.C.K.); [email protected] (E.J.); Tel.: +82-2-3010-3936 (S.C.K.); +82-2-3010-1696 (E.J.); Fax: +82-2-474-9027 (S.C.K.); +82-2-474-9027 (E.J.) Received: 13 July 2020; Accepted: 17 August 2020; Published: 19 August 2020 Abstract: This study was conducted to identify the composition and diversity of the microbiome in tissues of pancreatic cancer and to determine its role. -
Flavonoid Glucodiversification with Engineered Sucrose-Active Enzymes Yannick Malbert
Flavonoid glucodiversification with engineered sucrose-active enzymes Yannick Malbert To cite this version: Yannick Malbert. Flavonoid glucodiversification with engineered sucrose-active enzymes. Biotechnol- ogy. INSA de Toulouse, 2014. English. NNT : 2014ISAT0038. tel-01219406 HAL Id: tel-01219406 https://tel.archives-ouvertes.fr/tel-01219406 Submitted on 22 Oct 2015 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Last name: MALBERT First name: Yannick Title: Flavonoid glucodiversification with engineered sucrose-active enzymes Speciality: Ecological, Veterinary, Agronomic Sciences and Bioengineering, Field: Enzymatic and microbial engineering. Year: 2014 Number of pages: 257 Flavonoid glycosides are natural plant secondary metabolites exhibiting many physicochemical and biological properties. Glycosylation usually improves flavonoid solubility but access to flavonoid glycosides is limited by their low production levels in plants. In this thesis work, the focus was placed on the development of new glucodiversification routes of natural flavonoids by taking advantage of protein engineering. Two biochemically and structurally characterized recombinant transglucosylases, the amylosucrase from Neisseria polysaccharea and the α-(1→2) branching sucrase, a truncated form of the dextransucrase from L. Mesenteroides NRRL B-1299, were selected to attempt glucosylation of different flavonoids, synthesize new α-glucoside derivatives with original patterns of glucosylation and hopefully improved their water-solubility. -
Function-Structural Study of Anti-LDL-Oxidation Effects of Flavonoid Phytochemicals
Journal of Medicinal Plants Research Vol. 6(49), pp. 5895-5904, 25 December, 2012 Available online at http://www.academicjournals.org/JMPR DOI: 10.5897/JMPR12.313 ISSN 1996-0875 ©2012 Academic Journals Full Length Research Paper Function-structural study of anti-LDL-oxidation effects of flavonoid phytochemicals Yiwen Yao 1#, Shuqing Liu 2#, Chunmei Guo 3, Chunyan Zhang 3, Dachang Wu 3, Yixin Ren 2, Hong-Shan Yu 4, Ming-Zhong Sun 3 and Hailong Chen 5* 1Department of Otolaryngology, the First affiliated Hospital of Dalian Medical University, Dalian 116011, China. 2Department of Biochemistry, Dalian Medical University, Dalian 116044, China. 3Department of Biotechnology, Dalian Medical University, Dalian 116044, China. 4School of Bioengineering, Dalian Polytechnic University, Dalian 116034, China. 5Department of Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China Accepted 9 March, 2012 As a large group of polyphenolic phytochemicals with excellent anti-oxidation properties, the dietary flavonoid intakes have been shown to be negatively correlated with the incidence of coronary artery disease. Flavonoid compounds potentially inhibit the oxidation of low-density lipoprotein (Ox-LDL) that triggers the generation of a series of oxidation byproducts playing important roles in atherosclerosis development. The diverse inhibitory effects of different flavonoid phytochemicals on Ox-LDL might be closely associated with their intrinsic structures. In current work, we investigated the effects of eight flavonoid phytochemicals in high purity (>95%) with similar core structure on the susceptibility of LDL to Cu 2+ -induced oxidative modification. The results indicated that quercetin, rutin, isoquercitrin, hesperetin, naringenin, hesperidin, naringin and icariin could reduce the Cu 2+ -induced-LDL oxidation by 59.56 ±±±7.03, 46.53 ±±±2.09, 40.52 ±±±4.65, 22.67 ±±±1.68, 20.87 ±±±2.43, 12.34 ±±±2.09, 10.87 ±±±1.68 and 3.53 ±±±3.20%, respectively. -
(12) Patent Application Publication (10) Pub. No.: US 2013/0243709 A1 Hanson Et Al
US 201302437.09A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0243709 A1 Hanson et al. (43) Pub. Date: Sep. 19, 2013 (54) NATURAL SUNSCREEN COMPOSITION Publication Classification (71) Applicants: James E. Hanson, Chester, NJ (US); (51) Int. Cl. Cosimo Antonacci, East Hanover, NJ A6R8/97 (2006.01) (US) A61O 1704 (2006.01) (52) U.S. Cl. (72) Inventors: James E. Hanson, Chester, NJ (US); CPC. A61K 8/97 (2013.01); A61O 1704 (2013.01) Cosimo Antonacci, East Hanover, NJ USPC ............................................... 424/60; 424/59 (US) (57) ABSTRACT A composition for Sunscreen or Sunscreen enhancer is dis (21) Appl. No.: 13/795,305 closed. The composition includes UV-blocking component comprising natural extracts, natural oils or nutrients or a (22) Filed: Mar 12, 2013 combination of these. The composition is capable of protect ing skin from the harmful effects of UV-light and it is capable Related U.S. Application Data of acting as an enhancer of Sunscreen actives, such as Zinc (60) Provisional application No. 61/685, 166, filed on Mar. oxide, titanium dioxide or other Sunscreen actives, such as 13, 2012, provisional application No. 61/685,460, Avobenzone, Dioxybenzone, Ecamsule, Meradimate, Oxy filed on Mar. 19, 2012, provisional application No. benZone, Sulisobenzone, Cinoxate, Ensulizole, Homosalate, 61/690,257, filed on Jun. 23, 2012, provisional appli Octinoxate, Octisalate, Octocrylene PABA, Padimate O or cation No. 61/690,280, filed on Jun. 23, 2012. Trolamine Salicylate. US 2013/0243709 A1 Sep. 19, 2013 NATURAL SUNSCREEN COMPOSITION 0006 To overcome these undesirable side effects of organic and inorganic sunscreen agents, there is a need for PRIORITY new formulations that can protect the skin from the harmful effects of ultraviolet radiation without any undesirable side 0001) This application claims priority of U.S. -
Akkermansia Muciniphila Ameliorates the Age-Related Decline in Colonic
van der Lugt et al. Immunity & Ageing (2019) 16:6 https://doi.org/10.1186/s12979-019-0145-z RESEARCH Open Access Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1−/Δ7 mice Benthe van der Lugt1*†, Adriaan A. van Beek2,3†, Steven Aalvink4, Ben Meijer3, Bruno Sovran5, Wilbert P. Vermeij6,7, Renata M. C. Brandt6, Willem M. de Vos4,8, Huub F. J. Savelkoul3, Wilma T. Steegenga1 and Clara Belzer4* Abstract Background: The use of Akkermansia muciniphila as potential therapeutic intervention is receiving increasing attention. Health benefits attributed to this bacterium include an improvement of metabolic disorders and exerting anti-inflammatory effects. The abundance of A. muciniphila is associated with a healthy gut in early mid- and later life. However, the effects of A. muciniphila on a decline in intestinal health during the aging process are not investigated yet. We supplemented accelerated aging Ercc1−/Δ7 mice with A. muciniphila for 10 weeks and investigated histological, transcriptional and immunological aspects of intestinal health. Results: The thickness of the colonic mucus layer increased about 3-fold after long-term A. muciniphila supplementation and was even significantly thicker compared to mice supplemented with Lactobacillus plantarum WCFS1. Colonic gene expression profiles pointed towards a decreased expression of genes and pathways related to inflammation and immune function, and suggested a decreased presence of B cells in colon. Total B cell frequencies in spleen and mesenteric lymph nodes were not altered after A. muciniphila supplementation. Mature and immature B cell frequencies in bone marrow were increased, whereas B cell precursors were unaffected. -
Evaluation of Phytochemical and Anti-Oxidant Activity in Different Mulberry Varieties
Asian Journal of Chemistry; Vol. 25, No. 14 (2013), 8010-8014 http://dx.doi.org/10.14233/ajchem.2013.14938 Evaluation of Phytochemical and Anti-oxidant Activity in Different Mulberry Varieties 1 2 1,* SEEMA CHAUHAN , SUBASH CHANDRA VERMA and R. VENKATESH KUMAR 1Department of Applied Animal Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University (A Central University), Vidya Vihar, Raebareli Road, Lucknow-226 025, India 2The Central Council for Research in Ayurvedic Sciences, (Department of Ayush, MOH & FW), 61-65, Institutional Area, Opposite D-Block, Janakpuri, New Delhi-110 058, India *Corresponding author: E-mail: [email protected] (Received: 8 December 2012; Accepted: 29 July 2013) AJC-13861 The aims of present study were to screen phytochemical constituents and evaluate in vitro anti-oxidant activity of leaves of different varieties of mulberry plant [Family Moraceae]. The methanolic extract of leaves of different mulberry varieties namely S-13, S-54, BR-2, S-36 and S-1 which belongs to Morus alba and Morus indica were subjected for the phytochemical screening. The results obtained from the HPLC analysis, revealed that the methanolic extracts of mulberry leaves samples of S-36 and S-1 varieties contain more amount of phenolics and flavonoids. The in vitro FRAP assay clearly indicate that S-1 mulberry leaf extract have maximum significant FRAP concentration at 800 µL/mL and 1000 µL/mL (0.408 ± 0.001 mmol FeSO4/100 g dried sample and 0.410 ± 0.001 mmol FeSO4/100 g dried sample, respectively) a significant source of natural anti-oxidant, which might be helpful in preventing the progress of various oxidative stresses. -
Thopen Quercetin Paper Preprint.Pdf
Stainer, Alexander and Sasikumar, Parvathy and Bye, Alexander and Unsworth, Amanda and Holbrook, Lisa and Tindall, Mike and Lovegrove, Julie and Gibbins, Jonathan (2019) The Metabolites of the Dietary Flavonoid Quercetin Possess Potent Antithrombotic Activity, and Interact with Aspirin to Enhance Antiplatelet Effects. Thrombosis and Haemostasis Open, 03 (03). e244-e258. Downloaded from: https://e-space.mmu.ac.uk/623580/ Publisher: Thieme DOI: https://doi.org/10.1055/s-0039-1694028 Usage rights: Creative Commons: Attribution 4.0 Please cite the published version https://e-space.mmu.ac.uk The metabolites of the dietary flavonoid quercetin possess potent anti- thrombotic activity, and interact with aspirin to enhance anti-platelet effects Alexander R. Stainer1, Parvathy Sasikumar2, Alexander P. Bye1, Amanda J. Unsworth1,3, Lisa M. Holbrook1,4, Marcus Tindall5, Julie A. Lovegrove6, Jonathan M. Gibbins1* 1Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, UK 2 Centre for Haematology, Imperial College London, London, UK 3 School of Healthcare Science, Manchester Metropolitan University, Manchester, UK 4 School of Cardiovascular Medicine and Sciences, King’s College London, London, UK 5 Department of Mathematics and Statistics, University of Reading, Reading, UK 6 Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, UK * Corresponding author Professor Jonathan M. Gibbins, PhD, Professor of Cell Biology, Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, Harborne Building, University of Reading, Whiteknights, Reading, RG6 6AS, UK, [email protected], Tel +44 (0)118 3787082, Fax +44 (0)118 9310180 ABSTRACT Quercetin, a dietary flavonoid, has been reported to possess anti-platelet activity. -
Toxicological Safety Evaluation of Pasteurized Akkermansia Muciniphila
Received: 6 July 2020 Revised: 10 July 2020 Accepted: 10 July 2020 DOI: 10.1002/jat.4044 RESEARCH ARTICLE Toxicological safety evaluation of pasteurized Akkermansia muciniphila Céline Druart1 | Hubert Plovier1 | Matthias Van Hul2 | Alizée Brient3 | Kirt R. Phipps4 | Willem M. de Vos5,6 | Patrice D. Cani2 1A-Mansia Biotech SA, Mont-Saint-Guibert, Belgium Abstract 2Walloon Excellence in Life Sciences and Gut microorganisms are vital for many aspects of human health, and the commensal BIOtechnology (WELBIO), Metabolism and bacterium Akkermansia muciniphila has repeatedly been identified as a key compo- Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, Université nent of intestinal microbiota. Reductions in A. muciniphila abundance are associated catholique de Louvain, Brussels, Belgium with increased prevalence of metabolic disorders such as obesity and type 2 diabetes. 3Citoxlab France, Evreux, France It was recently discovered that administration of A. muciniphila has beneficial effects 4Intertek Health Sciences Inc., Farnborough, Hampshire, UK and that these are not diminished, but rather enhanced after pasteurization. Pasteur- 5Laboratory of Microbiology, Wageningen ized A. muciniphila is proposed for use as a food ingredient, and was therefore sub- University, Wageningen, the Netherlands jected to a nonclinical safety assessment, comprising genotoxicity assays (bacterial 6Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, reverse mutation and in vitro mammalian cell micronucleus tests) and a 90-day toxic- Helsinki, Finland ity study. For the latter, Han Wistar rats were administered with the vehicle or pas- Correspondence teurized A. muciniphila at doses of 75, 375 or 1500 mg/kg body weight/day Patrice D. Cani, UCLouvain, Université (equivalent to 4.8 × 109, 2.4 × 1010, or 9.6 × 1010 A. -
Engen Colostate 0053N 12223.Pdf (1.554Mb)
THESIS COMPARISON OF DOSE-DEPENDENT OUTCOMES IN INDUCTION OF CYTOGENOTOXIC RESPONSES BY NOVEL GLUCOSYL FLAVONOIDS Submitted by Anya Engen Department of Environmental and Radiological Health Sciences In partial fulfillment of the requirements For the degree of Master of Science Colorado State University Fort Collins, Colorado Spring 2014 Master’s Committee: Advisor: Takamitsu Kato Co-advisor: William Hanneman Marie Legare Gerrit Bouma Copyright by Anya Engen 2014 All Rights Reserved ABSTRACT COMPARISON OF DOSE-DEPENDENT OUTCOMES IN INDUCTION OF CYTOGENOTOXIC RESPONSES BY NOVEL GLUCOSYL FLAVONOIDS The flavonoids quercetin, and its glucosides isoquercetin and rutin, are phytochemicals commonly consumed in plant-derived foods. They are associated with potential health- promoting effects such as anti-inflammation, anti-viral, anti-carcinogenesis, neuro- and cardio- protection, etc. Semi-synthetic water soluble quercetin glucosides, maltooligosyl isoquercetin (MI), monoglucosyl rutin (MO) and maltooligosyl rutin (MA) were developed to overcome solubility challenges for improved incorporation in food and medicinal applications. Quercetin and its glucosides are known to induce genetic instability and decrease cell proliferation, which are possible mechanisms of anti-carcinogenesis in in vitro and animal studies. Using an in vitro system of Chinese hamster ovary (CHO) cells, this thesis project examined the differences in cytogenotoxic responses induced by natural and novel flavonoids. Treatments with flavonoids at a concentration range of 0.1 and 1,000 ppm induced sister chromatid exchanges (SCE) and micronuclei (MN) in CHO cells. Compared to spontaneous occurrences, significant increases in SCE and MN were observed in both natural and synthetic flavonoid-treated cells in a dose- dependent manner. The natural flavonoids exhibited greater potency than the synthetic compounds, where quercetin was most potent. -
Experimental Evaluation of Ecological Principles to Understand and Modulate the Outcome of Bacterial Strain Competition in Gut Microbiomes
Experimental evaluation of ecological principles to understand and modulate the outcome of bacterial strain competition in gut microbiomes Rafael R. Segura Munoz University of Nebraska-Lincoln Sara Mantz University of Nebraska-Lincoln Ines Martinez University of Alberta Robert J. Schmaltz University of Nebraska-Lincoln Jens Walter ( [email protected] ) APC Microbiome Ireland; University College Cork Amanda E. Ramer-Tait ( [email protected] ) University of Nebraska-Lincoln Research Article Keywords: Microbiome, niche, competitive exclusion, coexistence theory, gut ecosystems, engraftment, live biotherapeutics, intraspecic interactions, priority effects Posted Date: December 8th, 2020 DOI: https://doi.org/10.21203/rs.3.rs-123088/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/33 Abstract It is unclear if coexistence theory can be applied to gut microbiomes to understand their characteristics and modulate their composition. Through strictly controlled colonization experiments in mice, we demonstrated that strains of Akkermansia muciniphila and Bacteroides vulgatus could only be established if microbiomes were devoid of exactly these species. Strains of A. muciniphila showed strict competitive exclusion, while B. vulgates strains coexistedbut populations were still inuenced by competitive interactions. Priority effects were detected for both species as strains’ competitive tness increased when colonizing rst. Based on these observations, we devised a subtractive strategy for A. muciniphila using antibiotics and demonstrated that a strain from an assembled community can be stably replaced by another strain. Altogether, these results suggest that aspects of coexistence theory, e.g., niche partitioning and the impact of priority effects on tness differences, can be applied to explain ecological characteristics of gut microbiomes and modulate their composition.