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Terms Moving From Supplemental Concepts to Descriptor Records (Promotions) Term Type EntryTerm Moved 2017 UI 2017 Heading Moved To 2018 MeSH UI 2018 Heading From Entry Tem ATPase, Cu++ transporting, beta polypeptide (Wilson SCR C093154 Wilson disease protein Descriptor D000073840 Copper-transporting ATPases disease) Entry Tem DNA-binding protein CTCF SCR C109778 CCCTC-binding factor Descriptor D000076246 CCCTC-Binding Factor Entry Tem valosine-containing protein SCR C070098 CDC48 protein Descriptor D000074405 Valosin Containing Protein Heading COP9 signalosome complex SCR C088436 COP9 signalosome complex Descriptor D000075686 COP9 Signalosome Complex Entry Tem Campath 1M SCR C096529 alemtuzumab Descriptor D000074323 Alemtuzumab Entry Tem guanyl cyclase-C receptor SCR C032215 enterotoxin receptor Descriptor D000074261 Receptors, Enterotoxin Entry Tem valosin-containing protein SCR C070098 CDC48 protein Descriptor D000074405 Valosin Containing Protein Entry Tem monoclonal antibody Campath-1H SCR C096529 alemtuzumab Descriptor D000074323 Alemtuzumab Heading netrin-1 SCR C088893 netrin-1 Descriptor D000075388 Netrin-1 Heading C.I. Acid Red 27 SCR C493143 C.I.

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Phosphorylation of the Microtubule-Severing AAA+ Enzyme Katanin Regulates C
Phosphorylation of the microtubule-severing AAA+ enzyme Katanin regulates C. elegans embryo development Nicolas Joly, Eva Beaumale, Lucie van Hove, Lisa Martino, Lionel Pintard To cite this version: Nicolas Joly, Eva Beaumale, Lucie van Hove, Lisa Martino, Lionel Pintard. Phosphorylation of the microtubule-severing AAA+ enzyme Katanin regulates C. elegans embryo development. Journal of Cell Biology, Rockefeller University Press, 2020, 219 (6), 10.1083/jcb.201912037. hal-03011242 HAL Id: hal-03011242 https://hal.archives-ouvertes.fr/hal-03011242 Submitted on 18 Nov 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. ARTICLE Phosphorylation of the microtubule-severing AAA+ enzyme Katanin regulates C. elegans embryo development Nicolas Joly, Eva Beaumale, Lucie Van Hove, Lisa Martino, and Lionel Pintard The evolutionarily conserved microtubule (MT)-severing AAA-ATPase enzyme Katanin is emerging as a critical regulator of MT dynamics. In Caenorhabditis elegans, Katanin MT-severing activity is essential for meiotic spindle assembly but is toxic for the Downloaded from https://rupress.org/jcb/article-pdf/219/6/e201912037/1044138/jcb_201912037.pdf by guest on 20 July 2020 mitotic spindle. Here we analyzed Katanin dynamics in C. elegans and deciphered the role of Katanin phosphorylation in the regulation of its activity and stability.
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Deciphering the Role of a Microtubule Severing Protein and a Protein Kinase in Cell Cycle and Ciliogenesis in Chlamydomonas Reinhardtii
DECIPHERING THE ROLE OF A MICROTUBULE SEVERING PROTEIN AND A PROTEIN KINASE IN CELL CYCLE AND CILIOGENESIS IN CHLAMYDOMONAS REINHARDTII by M. Qasim Rasi B.Sc., Simon Fraser University, 2004 THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY In the Department of Molecular Biology and Biochemistry ©M. Qasim Rasi 2009 SIMON FRASER UNIVERSITY Summer 2009 All rights reserved. This work may not be reproduced in whole or in part, by photocopy or other means, without permission of the author APPROVAL Name: M. Qasim Rasi Degree: Doctor of Philosophy Title of Thesis: Deciphering the role of a microtubule severing protein and a protein kinase in cell cycle and ciliogenesis in Chlamydomonas reinhardtii Examining Committee: Chair: Dr. C. Krieger Professor of Kinesiology _______________________________________________ Dr. Lynne Quarmby Senior Supervisor; Professor of Molecular Biology and Biochemistry _______________________________________________ Dr. Michel Leroux Supervisor; Associate Professor of Molecular Biology and Biochemistry _______________________________________________ Dr. Nick Harden Supervisor; Associate Professor of Molecular Biology and Biochemistry _______________________________________________ Dr. Christopher Beh Internal Examiner; Associate Professor of Molecular Biology and Biochemistry _______________________________________________ Dr. Stephen M. King External Examiner; Professor of Biochemistry, Associate Director, Graduate Program in Molecular Biology and Biochemistry, University of Connecticut Health Center Date Defended/Approved: June-5-2009 ii Declaration of Partial Copyright Licence The author, whose copyright is declared on the title page of this work, has granted to Simon Fraser University the right to lend this thesis, project or extended essay to users of the Simon Fraser University Library, and to make partial or single copies only for such users or in response to a request from the library of any other university, or other educational institution, on its own behalf or for one of its users.
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The Tumor Suppressor LZTS2 Functions Through the Cellular Samurai Katanin
Cent. Eur. J. Biol. • 4(1) • 2009 • 1–10 DOI: 10.2478/s11535-008-0063-0 Central European Journal of Biology The tumor suppressor LZTS2 functions through the cellular samurai Katanin Mini-Review Yoshiro Maru* Department of Pharmacology, Tokyo Womens Medical University, 162-8666 Tokyo, Japan Received 10 September 2008; Accepted 16 December 2008 Abstract: The leucine zipper putative tumor suppressor (LZTS) 2 is frequently and specifically found in LOH (loss of heterozygosity) analysis in cancer. Different from other LZTS family members, it regulates the microtubule-severing protein Katanin by binding the p80 regulatory subunit of Katanin and inhibiting its interaction with microtubules. At specific phases of the cell cycle, LZTS2 suppresses cell migration and establishes proper central spindle assembly for cytokinesis. Importantly, those biological effects are mediated by the inhibitory activity of LZTS2 on Katanin. LZTS2 binding to Katanin also plays a role in Katanin transport to the midbody to control proper abscis- sion. Therapeutic applications of the interaction between LZTS2 and Katanin in tumor cells are a potential area for future research. Keywords: LAPSER1 • LZTS2 • Katanin • β-catenin • Microtubule • Cancer © Versita Warsaw and Springer-Verlag Berlin Heidelberg. 1. Introduction β-tubulin cause resistance to taxanes [2]. Farnesyltransferase inhibitors, which were initially found to inhibit the Ras oncoprotein, can enhance the binding Pharmaceutical discovery has been aided by elucidation between β-tubulin and taxanes to reverse resistance to of mechanisms by which tumor suppressors inhibit taxanes [3]. The genomic region that involves Aurora-A cancer progression. For example, the discovery of is commonly amplified in human tumors with taxane taxanes as microtubule-stabilizing drugs has shown resistance.
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The Importance of Lattice Defects in Katanin-Mediated Microtubule Severing in Vitro
2916 Biophysical Journal Volume 82 June 2002 2916–2927 The Importance of Lattice Defects in Katanin-Mediated Microtubule Severing in Vitro Liza J. Davis,* David J. Odde,† Steven M. Block,‡ and Steven P. Gross§ Departments of *Chemical Engineering and Materials Science and †Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455; ‡Department of Biological Sciences, Stanford University, Stanford, California 94305; and §Department of Developmental and Cell Biology, University of California-Irvine, Irvine, California 92697 USA ABSTRACT The microtubule-severing enzyme katanin uses ATP hydrolysis to disrupt noncovalent bonds between tubulin dimers within the microtubule lattice. Although its microtubule severing activity is likely important for fundamental processes including mitosis and axonal outgrowth, its mechanism of action is poorly understood. To better understand this activity, an in vitro assay was developed to enable the real-time observation of katanin-mediated severing of individual, mechanically unconstrained microtubules. To interpret the experimental observations, a number of theoretical models were developed and compared quantitatively to the experimental data via Monte Carlo simulation. Models that assumed that katanin acts on a uniform microtubule lattice were incompatible with the in vitro data, whereas a model that assumed that katanin acts preferentially on spatially infrequent microtubule lattice defects was found to correctly predict the experimentally observed breaking rates, number and spatial frequency of severing events, final levels of severing, and sensitivity to katanin concen- tration over the range 6–300 nM. As a result of our analysis, we propose that defects in the microtubule lattice, which are known to exist but previously not known to have any biological function, serve as sites for katanin activity.
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Microtubule Motors
Microtubule Forces Kevin Slep Microtubules are a Dynamic Scaffold Microtubules in red, XMA215 family MT polymerase protein in green Some Microtubule Functions Cell Structure Polarized Motor Track (kinesins and dynein) Cilia structure (motile and sensory) Mitotic and meiotic spindle structure Cell polarity Coordinate cell motility with the F-actin network Architecture of Tubulin and the Microtubule α/β-Tubulin: The Microtubule Building Block Tubulin is a heterodimer composed of α and β tubulin α and β tubulin are each approximately • 55 kD and are structurally very similar to •each other. •Each tubulin binds GTP: The α GTP is non- exchangeable and the dimer is very stable, Kd = 10-10; the β GTP is exchangeable in the dimer The Microtubule Architecture Tubulin binds head-to-tail along + protofilaments, forming LONGITUDINAL interactions. Longitudinal interactions complete the active site for GTP hydrolysis 13 protofilaments form a hollow tube-the microtubule: 25 nm OD, 14 nm ID (protofilaments interact via LATERAL interactions) The MT is a left-handed helix with a seam, it rises 1.5 heterodimers per turn (α and β form lateral interactions) MTs are polar-they have a plus end and a minus end - The γTubulin Ring Complex (γTuRC) forms a lockwasher to nucleate MTs Axial view Side View γTuRC positions nucleated 13 γTubulins in a ring γTuRC attachment microtubule The Centrosome is a Microtubule Organizing Center (MTOC) rich in γTuRC MTOC’s control where microtubules are formed Centrosomes contain peri-centrosomal material (PCM) surrounding a pair of centrioles γTuRC nucleation complexes are localized to the PCM Centrioles within centrosomes become basal bodies, which are nucleation centers for cilia (motile and primary) and flagella Centrosomes duplicate once per cell cycle Mother centriole nucleates growth of a daughter centriole with an orthogonal orientation Microtubule Polarity and Dynamics Polarized Microtubule Organization in Vivo Centrosome + + + + + + + + + Interphase Mitosis Microtubules are Dynamic Fish melanophore injected with Cy3-tubulin Vorobjev, I.A.
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The Mitotic Tensegrity Guardian Tau Protects Mammary Epithelia from Katanin-Like1-Induced Aneuploidy
www.impactjournals.com/oncotarget/ Oncotarget, Vol. 7, No. 33 Research Paper The mitotic tensegrity guardian tau protects mammary epithelia from katanin-like1-induced aneuploidy Haruka Sudo1,2, Kazunori Nakajima2 1Department of Biochemistry, The Nippon Dental University School of Life Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan 2Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan Correspondence to: Haruka Sudo, email: [email protected] Keywords: breast cancer, chromosome instability, microtubule severing, mitotic spindle, tau Received: January 17, 2016 Accepted: June 16, 2016 Published: July 20, 2016 ABSTRACT The microtubule associated-protein tau has been identified as an effective positive prognostic indicator in breast cancer. To explore the physiological function of tau in early carcinogenesis, endogenous tau was knocked down in primary cultured human mammary epithelial cells. This resulted in chromosome-bridging during anaphase followed by micronucleation, both of which were suppressed by a further katanin- like1 knockdown. We also detected that the exogenously expressed katanin-like1 induction of cellular transformation is prevented by exogenous tau in rat fibroblasts. The mutant katanin-like1 (L123V) identified in breast cancer showed an increase in this transformation capacity as well as microtubule severing activity resistant to tau. The tau knockdown resulted in a loss of the kinetochore fibers on which tau is normally localized. This physical fragility was also observed in isolated tau- knockdown mitotic spindles, supporting the relevance of microtubule damage to the onset of transformation. The karyotyping of tau-knockdown cells showed increased frequency of loss of one X chromosome, further suggesting the involvement of tau in breast tumorigenesis.
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Augmin-Mediated Amplification of Long-Lived Spindle Microtubules Directs Plus-Ends to Kinetochores
bioRxiv preprint doi: https://doi.org/10.1101/501445; this version posted December 19, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Augmin-mediated amplification of long-lived spindle microtubules directs plus-ends to kinetochores Authors: Ana F. David1, Philippe Roudot2, Wesley R. Legant3, 4, Eric Betzig3, Gaudenz Danuser2, and Daniel W. Gerlich1* Affiliations: 1Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), 1030 Vienna, Austria. 2Department oF Cell Biology and Lyda Hill Department oF BioinFormatics, University oF Texas Southwestern Medical Center, Dallas, USA. 3Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, USA. 4Present address: Department oF Biomedical Engineering, Department oF Pharmacology, University oF North Carolina Chapel Hill, Chapel Hill, USA. *Correspondence to D.W.G., ORCID 0000-0003-1637-3365, Email: [email protected] Dividing cells reorganize their microtubule cytoskeleton into a bipolar spindle, which moves one set of sister chromatids to each nascent daughter cell. Early spindle assembly models postulated that spindle-pole-derived microtubules search the cytoplasmic space until they randomly encounter a kinetochore to form a stable attachment. More recent work uncovered several additional, centrosome-independent microtubule generation pathways, but the contributions of each pathway to spindle assembly have remained unclear. Here, we combined live microscopy and mathematical modeling to show that most microtubules nucleate at non-centrosomal regions in dividing human cells.
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Supplemental Table S-2. Genes That Were Differentially Regulated by 2-Fold Or Greater Between Male and Female Tendons
Supplemental Table S-2. Genes that were differentially regulated by 2-fold or greater between male and female tendons. Log Fold Affymetrix Change Male vs Probe ID Entrez ID Symbol Description Female 17543785 213742 Xist inactive X specific transcripts -5.47 17426022 100041687 Mup8 major urinary protein 8 -3.73 17426062 100048885 Gm2083 major urinary protein LOC100048885 -3.53 17426043 100048885 Gm2083 major urinary protein LOC100048885 -3.50 17297591 NA NA NA -3.50 17426011 100048885 Gm2083 major urinary protein LOC100048885 -3.46 17425990 100048885 Gm2083 major urinary protein LOC100048885 -3.46 17425915 100048885 Gm2083 major urinary protein LOC100048885 -3.46 17425941 100048885 Gm2083 major urinary protein LOC100048885 -3.40 17517360 66402 Sln sarcolipin -3.18 17426032 100048885 Gm2083 major urinary protein LOC100048885 -3.12 17346069 240120 Zfp119b zinc finger protein 119b -3.07 17426000 100048885 Gm2083 major urinary protein LOC100048885 -3.03 17425900 100048885 Gm2083 major urinary protein LOC100048885 -2.91 17425888 100048885 Gm2083 major urinary protein LOC100048885 -2.85 17315002 70152 Mettl7a1 methyltransferase like 7A1 -2.62 17248348 NA NA NA -2.41 17524209 NA NA NA -2.39 17443890 24135 Zfp68 zinc finger protein 68 -2.38 17238834 NA NA NA -2.33 17343251 108121 U2af1 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1 -2.32 17406421 99889 Arfip1 ADP-ribosylation factor interacting protein 1 -2.30 17497612 93747 Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial -2.22 17238892 NA NA NA -2.22 17238934 64009
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Katanin P80, Numa and Cytoplasmic Dynein Cooperate to Control
www.nature.com/scientificreports OPEN Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics Received: 24 June 2016 Mingyue Jin1,*, Oz Pomp2,*, Tomoyasu Shinoda3, Shiori Toba1, Takayuki Torisawa4,5, Accepted: 29 November 2016 Ken’ya Furuta4,5, Kazuhiro Oiwa4,5,6, Takuo Yasunaga7,8,9, Daiju Kitagawa10, Published: 12 January 2017 Shigeru Matsumura11, Takaki Miyata3, Thong Teck Tan2, Bruno Reversade2,12,13,# & Shinji Hirotsune1,# Human mutations in KATNB1 (p80) cause severe congenital cortical malformations, which encompass the clinical features of both microcephaly and lissencephaly. Although p80 plays critical roles during brain development, the underlying mechanisms remain predominately unknown. Here, we demonstrate that p80 regulates microtubule (MT) remodeling in combination with NuMA (nuclear mitotic apparatus protein) and cytoplasmic dynein. We show that p80 shuttles between the nucleus and spindle pole in synchrony with the cell cycle. Interestingly, this striking feature is shared with NuMA. Importantly, p80 is essential for aster formation and maintenance in vitro. siRNA-mediated depletion of p80 and/or NuMA induced abnormal mitotic phenotypes in cultured mouse embryonic fibroblasts and aberrant neurogenesis and neuronal migration in the mouse embryonic brain. Importantly, these results were confirmed in p80-mutant harboring patient-derived induced pluripotent stem cells and brain organoids. Taken together, our findings provide valuable insights into the pathogenesis of severe microlissencephaly, in which p80 and NuMA delineate a common pathway for neurogenesis and neuronal migration via MT organization at the centrosome/spindle pole. A prominent trait of the neocortex is its complex yet elaborately organized cellular architecture, the formation of which relies on strictly regulated neurogenesis and neuronal migration.
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Chapter 2. Loss of Katanin-60 (Kat60) Affects Pupal Brain Development
In Vivo Analysis of the Microtubule Severing Protein Katanin-60 in the Drosophila Nervous System by Lisa M. Pang Department of Biology Duke University Date:_______________________ Approved: ___________________________ Nina Tang Sherwood, Supervisor ___________________________ Vann Bennett ___________________________ Amy Bejsovec ___________________________ David McClay ___________________________ W. Daniel Tracey Dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biology in the Graduate School of Duke University 2012 i v ABSTRACT In Vivo Analysis of the Microtubule Severing Protein Katanin-60 in the Drosophila Nervous System by Lisa M. Pang Department of Biology Duke University Date:_______________________ Approved: ___________________________ Nina Tang Sherwood, Supervisor ___________________________ Vann Bennett ___________________________ Amy Bejsovec ___________________________ David McClay ___________________________ W. Daniel Tracey An abstract of a dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biology in the Graduate School of Duke University 2012 Copyright by Lisa Pang 2012 Abstract Microtubules, dynamic structures that make up the cellular cytoskeleton, are essential for cellular transport, motility, division, and structural stability. Accordingly, their dynamics must be tightly regulated. One such method of regulation utilizes microtubule severing proteins that use ATP to sever the microtubule by disrupting the tubulin-tubulin interactions within the microtubule lattice. Knowledge of the in vivo function of the microtubule severing protein Katanin-60 (Kat60) in nervous system development remains lacking, despite numerous cell culture studies concerning its role in dividing cells and mammalian neurons. Genetic deletion of Drosophila kat60 results in only 15% of the expected number of adult mutant flies.
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A Meta-Analysis of the Effects of High-LET Ionizing Radiations in Human Gene Expression
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ADP-Ribosylation Factor-Like 3, a Manchette-Associated Protein, Is Essential for Mouse Spermiogenesis
Molecular Human Reproduction, Vol.19, No.5 pp. 327–335, 2013 Advanced Access publication on January 12, 2013 doi:10.1093/molehr/gat001 ORIGINAL RESEARCH ADP-ribosylation factor-like 3, a manchette-associated protein, is essential for mouse spermiogenesis Yujuan Qi†, Min Jiang†, Yan Yuan, Ye Bi, Bo Zheng, Xuejiang Guo, Xiaoyan Huang*, Zuomin Zhou*, and Jiahao Sha State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, 140 Hanzhong Road, Downloaded from Nanjing, Jiangsu Province 210029, China *Correspondence address. Tel: +86-025-86862908; Fax: +86-025-86862908; E-mail: [email protected] (X.H.); [email protected] (Z.Z.) Submitted on October 29, 2012; resubmitted on December 24, 2012; accepted on January 4, 2013 http://molehr.oxfordjournals.org/ abstract: During spermiogenesis, the manchette is an important structure for sperm head and tail formation. However, the mechan- isms responsible for this process are poorly understood. In a previous study, we established a comparative proteome profile for mouse testis during the first wave of spermatogenesis, and provided lists of proteins of potential importance in the regulation of male fertility and infertility. Here we have selected Arl3, one of these interesting proteins, and investigated its expression and function during spermiogenesis. Western blotting was used to determine Arl3 expression levels in mice at different time points from birth to adulthood. The results show Arl3 was expressed from birth, and the expression level increased significantly from Week 4, when mouse spermiogenesis begins. Immunohistochem- istry and indirect immunofluorescence were used to investigate the Arl3 expression during sperm development, and the intracellular local- ization of Arl3 in more detail.
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