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Final Program JULY 6 - 9, 2021 | BOSTON, MA MARRIOTT COPLEY PLACE VIRTUAL OPTION AVAILABLE NAVIGATING THE FUTURE FOR REPRODUCTIVE SCIENCE Society for Reproductive Investigation 68th Annual Scientific Meeting Photo Credit: Kyle Klein Table of Contents Message from the SRI President .............................................................................................................1 2021 Program Committee ......................................................................................................................2 General Meeting Information .................................................................................................................3 Meeting Attendance Code of Conduct Policy ..........................................................................................5 Schedule-at-a-Glance ............................................................................................................................7 Boston Information and Social Events ....................................................................................................8 Exhibitors ...............................................................................................................................................9 Hotel Map ............................................................................................................................................10 Continuing Medical Education Information ..........................................................................................11 Scientific Program Tuesday, July 6 .................................................................................................................................12 Wednesday, July 7 ...........................................................................................................................19 Thursday, July 8 ...............................................................................................................................32 Poster Guide .........................................................................................................................................46 2021 Awards ........................................................................................................................................76 About SRI .............................................................................................................................................78 Oral and Poster Abstract Author Index .................................................................................................82 SRI Council & Staff ................................................................................................................................99 Notes ..................................................................................................................................................100 Thank You to Our 2021 Supporters .....................................................................................................101 Save the Date: SRI 2022 Annual Meeting ...........................................................................................102 SRI 68th Annual Scientific Hotel and Meeting Venue Marriott Copley Place 110 Huntington Ave, Boston, MA, 02116 USA Future SRI Annual Scientific Meetings SRI 69th Annual Scientific Meeting • Denver, CO • March 15 – 19, 2022 SRI 70th Annual Scientific Meeting • Brisbane, QLD, Australia • March 21 - 25, 2023 SRI 71st Annual Scientific Meeting • Vancouver, BC, Canada • March 12 - 16, 2024 Society for Reproductive Investigation 555 East Wells Street, Suite 1100 • Milwaukee, WI 53202-3823 Phone: +1-414-918-9888 • Fax: +1-414-276-3349 Email: [email protected] • Website: www.sri-online.org © Society for Reproductive Investigation. All Rights Reserved. Final Program JULY 6 - 9, 2021 | BOSTON, MA Message from the SRI President Welcome to the 68th Annual Meeting of the Society for Reproductive Investigation (SRI), July 6 - 9, 2021 in Boston, MA, USA. The theme of the 2021 is meeting, “Navigating the Future for Reproductive Science”. For the first time, the 2021 SRI Annual meeting will be held in a hybrid format—providing options for both in-person and virtual attendance! Watch your email for a link to the virtual platform, so that you can enjoy ALL sessions. The theme of the 2021 meeting is, “Navigating the Future for Reproductive Science.” With Irina Burd, MD, PhD, as Program Director, the Program Committee has developed an outstanding program that includes President’s Distinguished Researchers, career development activities, Oral Sessions, invited Mini-Symposia, invited Lunch and Learn Symposia and a Hot Topics Plenary Session. The meeting will feature inspiring talks from two outstanding President’s Distinguished Researcher Awardees: Joan Steitz, PhD, 2018 Lasker-Koshland Awardee from the Yale School of Medicine and Gregg Semenza, MD, PhD, 2019 Nobel Laureate from Johns Hopkins. In addition, Susan Fisher, PhD, the 2020 March of Dimes Developmental Biology Prize Awardee from University of California, San Francisco will deliver an exciting lecture on her research. Several career development activities and networking opportunities will be offered, including Career Development Workshops, “Your Grant in One Page Clinic,” and “Connection Corners.” Also NEW this year, the Diversity, Equity, and Inclusion Forum, led by our new Vice President for Diversity and Structural Change, will be held on Thursday, July 8, over the lunch hour, giving all participants an option to attend. To allow all abstract submitters to participate and share their science, all posters will be virtual this year. However, poster presenters were invited to hang their poster in the poster hall, and so we invite you to visit the hall during the scheduled hours to view the science in person! Watch for the newly added abstract categories this year including Women’s Health Disparities and Inequities and COVID-19. While restrictions have been listed here in Boston, the SRI leadership strongly has encouraged all in-person attendees to come vaccinated. While masks are not required, we encourage you to do what is comfortable. As always, the 68th Annual SRI Meeting will be highly collegial and provide a forum for outstanding science and the opportunity for fruitful global networking. On behalf of the SRI Council, Program Committee, and Staff, we are pleased to offer this NEW option for participation! Come in person or connect online to share your science with your friends and colleagues at SRI! Sincerely Yours, James Segars, MD Irina Burd, MD, PhD SRI President, 2019-2021 SRI Program Director, 2021 NAVIGATING THE FUTURE FOR REPRODUCTIVE SCIENCE 1 2021 Program Committee 2021 Program Director Thomas Jansson, MD, PhD Irina Burd, MD, PhD University of Colorado Johns Hopkins University Dineo Khabele, MD Washington University, St. Louis Program Committee Chair: Emre Seli, MD Shannon Laughlin-Tommaso, MD Yale School of Medicine Mayo Clinic Carole Mendelson, PhD Incoming Program Chair: UT Southwestern Bo Rueda, PhD Leslie Myatt, PhD, FRCOG MGH / Harvard Medical School Oregon Health and Science University Charles Ducsay, PhD Mana Parast, MD, PhD Loma Linda University University of California San Diego Asgi Fazleabas, PhD Nanette Santoro, MD Michigan State University University of Colorado Dino A. Giussani, PhD, ScD, FRCOG James Segars, MD University of Cambridge Johns Hopkins University School of Medicine Nardhy Gomez-Lopez, PhD Shannon Whirledge, MD Wayne State University SOM Yale School of Medicine Jessica Hebert, PhD Portland State University/Oregon Health & Science University 2 Final Program JULY 6 - 9, 2021 | BOSTON, MA General Meeting Information Meeting Description The SRI Annual Meeting gathers leading scientists and clinical investigators annually to share cutting-edge information in reproductive sciences and women’s health. The 68th Annual Meeting will feature an exciting lineup of distinguished speakers, 12 mini-symposia sessions, career development sessions, and excellent scientific oral and poster presentations. Meeting Location Marriott Copley Place 110 Huntington Ave Boston, MA, 02116 USA +1 617-236-5800 Meeting Objectives • Provide attendees with state-of-the-art knowledge in the reproductive sciences and women’s health research fields. • Gain insight into future directions from critical analysis of investigative findings. • Distinguished lectures and symposia will provide a focused format that fosters more meaningful dialogue among clinicians and researchers • Connect and network with international leaders who are advancing the scientific study of repro- ductive and women’s health. Target Audience Scientists and clinical investigators who conduct basic, translational and clinical investigation in repro- ductive sciences and women’s health. Authorship Policy All authors connected to a presentation and/or abstract must agree on all information contained in the presentation. Failure of an author to agree to the presentation format will lead to the presentation being withdrawn from the conference. An author who submits a presentation to the Annual Meeting must have intentions of attending, registering, and presenting at the meeting once the submission is accepted into the program. Repeated or consecutive last-minute cancellations by presenters may result in future submissions being denied. Photography Disclaimer By registering for the SRI Annual Meeting, you give consent to be photographed by SRI staff for purpos- es of advertising and public display. Session