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Milk & Dairy Beef Drug Residue Prevention

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Milk & Dairy Beef Drug Residue Prevention TM Milk & Dairy Beef Drug Residue Prevention REFERENCE MANUAL 2018 TM National Milk Producers Federation (NMPF) does not endorse any of the veterinary drugs or tests identified on the lists in this manual. The lists of veterinary drugs and tests are provided only to inform producers and veterinarians what products may be available, and the producer and veterinarian are responsible for determining whether to use any of the veterinary drugs or tests. All information regarding the veterinary drugs or tests was obtained from the products’ manufacturers or sponsors, and NMPF has made no further attempt to validate or corroborate any of that information. NMPF urges producers to consult with their veterinarians before using any veterinary drug or test, including any of the products identified on the lists in this manual. In the event that there might be any injury, damage, loss or penalty that results from the use of these products, the manufacturer of the product or the producer using the product shall be responsible. NMPF is not responsible for, and shall have no liability for, any injury, damage, loss or penalty. © 2018 National Milk Producers Federation This manual is not a legal document and is intended for educational purposes only. Dairy farmers are individually responsible for determining and complying with all requirements of local, state and federal laws and regulations regarding animal care. 2 PRODUCT INFORMATION NADA 141-299, Approved by FDA. (Florfenicol and Flunixin Meglumine) Antimicrobial/Non-Steroidal Anti-Inflammatory Drug For subcutaneous use in beef and non-lactating dairy cattle only. Not for use in female dairy cattle 20 months of age or older or in calves to be processed for veal. BRIEF SUMMARY: For full prescribing information, see package insert. INDICATION: RESFLOR GOLD® is indicated for treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis, and control of BRD-associated pyrexia in beef and non-lactating dairy cattle. CONTRAINDICATIONS: Do not use in animals that have shown hypersensitivity to florfenicol or flunixin. WARNINGS: NOT FOR HUMAN USE. KEEP OUT OF REACH OF CHILDREN. This product contains material that can be irritating to skin and eyes. Avoid direct contact with skin, eyes, and clothing. In case of accidental eye exposure, flush with water for 15 minutes. In case of accidental skin exposure, wash with soap and water. Remove contaminated clothing. Consult a physician if irritation persists. Accidental injection of this product may cause local irritation. Consult a physician immediately. The Material Safety Data Sheet (MSDS) contains more detailed occupational safety information. For customer service or to obtain a copy of the MSDS, call 1-800-211-3573. For technical assistance or to report suspected adverse reactions, call 1-800-219-9286. Not for use in animals intended for breeding purposes. The effects of florfenicol on bovine reproductive performance, pregnancy, and lactation have not been determined. Toxicity studies in dogs, rats, and mice have associated the use of florfenicol with testicular degeneration and atrophy. NSAIDs are known to have potential effects on both parturition and the estrous cycle. There may be a delay in the onset of estrus if flunixin is administered during the prostaglandin phase of the estrous cycle. The effects of flunixin on imminent parturition have not been evaluated in a controlled study. NSAIDs are known to have the potential to delay Knock out BRD and take down the fever that usually comes with it when you use parturition through a tocolytic effect. Resflor Gold® (florfenicol and flunixin meglumine). The only major antibiotic to combine RESFLOR GOLD®, when administered as directed, the BRD-treating action of florfenicol with the symptom-fighting action of flunixin. With may induce a transient reaction at the site of injection one shot, Resflor Gold makes your animals feel better within six hours.1,2 So they aren’t and underlying tissues that may result in trim loss of just back on their feet eating and drinking, they’re back on track. Talk to your Merck edible tissue at slaughter. Animal Health rep or visit resflorgold.com to learn more. RESIDUE WARNINGS: Animals intended for human consumption must not be slaughtered within 38 days of treatment. Do not use in female dairy cattle 20 months of age or older. Use of florfenicol in this class of cattle may cause milk residues. A withdrawal period has not been established in pre-ruminating calves. Do not use in calves to be processed for veal. IMPORTANT SAFETY INFORMATION NOT FOR HUMAN USE. KEEP OUT OF REACH OF CHILDREN. This product contains material that can be irritating to skin and eyes. Animals intended for human consumption must not be slaughtered within ADVERSE REACTIONS: Transient inappetence, 38 days of treatment. This product is not approved for use in female dairy cattle 20 months of age or older, including diarrhea, decreased water consumption, and injection dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. A withdrawal site swelling have been associated with the use of period has not been established in preruminating calves. Do not use in calves to be processed for veal. Do not use florfenicol in cattle. In addition, anaphylaxis and collapse have been reported post-approval with the in animals that have shown hypersensitivity to florfenicol or flunixin. Not for use in animals intended for breeding use of another formulation of florfenicol in cattle. purposes. The effects of florfenicol and flunixin on bovine reproductive performance, pregnancy, and lactation have not been determined. When administered according to the label directions, RESFLOR GOLD may induce a transient In cattle, rare instances of anaphylactic-like reactions, local reaction in the subcutaneous and underlying muscle tissue. some of which have been fatal, have been reported, primarily following intravenous use of flunixin 1 Exhibits bactericidal activity against some strains of Mannheimia haemolytica and Histophilus somni. meglumine. 2 The correlation between in vitro susceptibility data and clinical effectiveness is unknown. merck-animal-health-usa.com • 800-521-5767 Copyright ©2017 Intervet Inc., doing business as Merck Animal Health, a subsidiary of Merck & Co., Inc. All rights reserved. Made in Germany 9/17 BV-RG-56197-D Intervet Inc. Roseland, NJ 07068 ©2009, Intervet Inc. All Rights Reserved. 3 May 2009 US 3448_IV Foreword The goal of our nation’s dairy farmers is to protocols that ensure that antimicrobials are produce the best tasting and most wholesome used correctly. Once a decision is made to use milk possible. Our consumers demand the best antimicrobials, then protocols must be in place from us and we meet their needs and exceed to guide employees on the safe way to handle the their expectations every day. Day in and day animal to prevent an inadvertent milk or meat out, our dairy farmers provide the best in animal residue from occurring. Identification of treated husbandry. Continually, we evaluate our best animals and recording drug use are essential management practices and disease prevention to prevent residues. For nearly 30 years, each protocols to keep our animals healthy and revision of the Milk & Dairy Beef Drug Residue comfortable. There are occasions when animals Prevention Reference Manual has served as the may get sick and need antimicrobial therapy to U.S. dairy industry’s commitment to antimicrobial overcome a specific disease challenge. As dairy stewardship – the judicious and responsible use of producers, we strategically and judiciously use our antibiotics and other drugs in dairy animals. This antimicrobial therapy to help an individual animal year’s revised manual is a quick resource to review that has been threatened with a disease. those drugs approved for dairy animals and can also be used as an educational tool and resource We take this responsibility of judicious for farm managers as they develop on-farm best antimicrobial use seriously and take many management practices. I encourage all dairy precautions with our antibiotic-treated animals farmers to sit down with their veterinarians and so that their milk or meat does not enter the employees to review this manual as you will food supply. The avoidance of milk and meat find the information useful, practical and easily residues in the dairy industry takes an on-farm applied to your individual farms. team effort that begins with the VCPR – the Veterinarian-Client-Patient Relationship. Dairy farm owners/managers/herdsman must work with their veterinarians to develop treatment Sincerely, Karen Jordan, DVM Dairy Producer Chair – NMPF Animal Health and Well-being Committee 4 Foreword Table of Contents Chapter 1: Introduction 6 Lactating Cows • Antimicrobial Stewardship 8 • Injectable Use 40 • Animal Drugs 8 • Intramammary Use 41 • Milk Drug Residue Testing 11 • Oral Use 41 • Multi-Drug Screening Test • Feed Additive Use 42 for Bulk Tank Milk 11 • Intravaginal Administration 42 • Meat Drug Residue Testing 12 • Topical Use 42 • Conditions that Warrant Screening Tests Additional Testing at USDA • Serum and Urine Screening Tests 44 Slaughter Facilities 16 • Milk Screening Tests 49 • Records Management 17 • Test Contact Information 69 Chapter 2: Residue Appendix 70 Overview 20 • Drugs Prohibited from Extra-Label • Considerations for Culling 71 Use in Animals 22 • Pharmaceutical Administration 72 • Drugs Not Approved
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