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Evidence Vs Experience in the Surgical Management of Necrotizing Enterocolitis and Focal Intestinal Perforation

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Evidence Vs Experience in the Surgical Management of Necrotizing Enterocolitis and Focal Intestinal Perforation Journal of Perinatology (2008) 28, S14–S17 r 2008 Nature Publishing Group All rights reserved. 0743-8346/08 $30 www.nature.com/jp ORIGINAL ARTICLE Evidence vs experience in the surgical management of necrotizing enterocolitis and focal intestinal perforation CJ Hunter1,2, N Chokshi1,2 and HR Ford1,2 1Department of Surgery, University of Southern California Keck School of Medicine, Los Angeles, CA, USA and 2Department of Surgery, Childrens Hospital Los Angeles, Los Angeles, CA, USA bacterial colonization and prematurity.4 There is a subset of low Introduction: Necrotizing enterocolitis (NEC) and focal intestinal birth weight infants, however, that sustain focal intestinal perforation (FIP) are neonatal intestinal emergencies that affect premature perforation (FIP) without classic clinical, radiographic, or infants. Although most cases of early NEC can be successfully managed with histological evidence of NEC.5 FIP appears to be a distinct clinical medical therapy, prompt surgical intervention is often required for advanced entity that occurs in 3% of very low birth weight (VLBW) infants or perforated NEC and FIP. and accounts for 44% of gastrointestinal perforations in this 6 Method: The surgical management and treatment of FIP and NEC are population. Optimal surgical management of severe NEC and discussed on the basis of literature review and our personal experience. FIP has been the subject of ongoing controversy for many years. Result: Surgical options are diverse, and include peritoneal drainage, laparotomy with diverting ostomy alone, laparotomy with intestinal Presentation of NEC and FIP resection and primary anastomosis or stoma creation, with or without Infants with NEC typically present with feeding intolerance and second-look procedures. bloody stools in the second or third week of life. In the more Conclusion: The optimal surgical therapy for FIP and NEC begins with advanced cases, they often demonstrate signs of sepsis and prompt diagnosis and adequate fluid resuscitation. It appears that there is cardiovascular collapse.7 The severity of NEC is classified according no significant difference in patient outcome based on surgical to the staging criteria established by Bell et al.8 The mortality of management alone. However, the infant’s weight, comorbidities, surgeon patients with stage III NEC approaches 40 to 100%. Radiographic preference and timing of intervention should be taken into account before evidence of NEC is characterized by the pathognomonic finding of operative intervention. pneumatosis intestinalis. Other findings include fixed intestinal Journal of Perinatology (2008) 28, S14–S17; doi:10.1038/jp.2008.44 loops, gas within the portal system or pneumoperitoneum.9 Patients with FIP usually present around the first week of life and Keywords: necrotizing enterocolitis; surgery; intestinal perforation do not exhibit the prodromal clinical symptoms or radiographic findings associated with NEC.5 However, patients with FIP may have radiographic evidence of pneumoperitoneum. Etiologic factors Introduction implicated in the pathogenesis of FIP include the use of umbilical Necrotizing enterocolitis (NEC) is the most common catheters, administration of indomethacin or steroid and 1 gastrointestinal emergency that affects newborn infants. A total of congenital defects of the intestinal wall.10,11 In general, the 90% of NEC cases occur in premature infants, with only 10% outcome for patients with FIP is more favorable than for those with occurring in full-term infants; most of whom also have NEC. However, despite appropriate and timely medical comorbidities predisposing them to decreased mesenteric management, over one-third of patients with NEC, and virtually all 2 perfusion. Despite major advances in neonatal medicine that have patients with FIP will require surgical intervention.12,13 resulted in improved outcomes over the past 20 years, the morbidity and mortality associated with NEC remain largely unchanged, and the incidence of NEC continues to increase.3 Although the precise Surgical options in patients >1500 g pathophysiology of NEC is poorly defined, three key contributing In infants with a birth weight >1500 g, laparotomy and resection factors have been identified; these include: early enteral feeding, of the necrotic intestine is generally the preferred approach. In some cases necrosis is limited to an isolated segment of intestine; Correspondence: Dr HR Ford, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, Mail Stop no. 35, Los Angeles, CA 90027, USA. while in others, the disease pattern is more diffuse, involving E-mail: [email protected] multiple segments of small and/or large bowel, with intervening Optimal surgical management of NEC and FIP CJ Hunter et al S15 strategy often resulted in the killing of potentially viable intestine. Hence, some surgeons advocated the ‘patch, drain and wait’ approach.18 In this technique each perforation is debrided and closed, penrose drains are placed and parenteral nutritional support is instituted. In cases of pan-necrosis, outcome is often extremely poor despite aggressive surgical intervention. Our recommendation for diffuse disease is initial laparotomy with proximal diversion alone. If the patient is highly unstable, peritoneal drainage (PD) may be utilized while resuscitation is ongoing. PD should be followed by delayed laparotomy. Laparotomy has the added benefit of allowing confirmation of the severity and extent of intestinal involvement. Focal intestinal perforation is unusual in patients weighing >1500 g as they more commonly develop NEC. Due to the of the limited anatomical area involved, some surgeons advocate primary anastomosis in this setting, or in the setting of focal segmental necrosis, as mentioned earlier.14,19 These small retrospective studies Figure 1 Segments of intestine affected by necrotizing enterocolitis (NEC). The argue that primary anastomosis is safe and effective. However, a classic findings of diffuse NEC are seen in this image. Patchy areas of necrosis are larger retrospective study by Cooper et al.20 reported a 24% lower seen with questionable intestinal viability. survival rate for patients who underwent primary anastomosis compared to ostomy creation. On the basis of the current available areas of questionable viability (Figure 1). The goal is to limit the data, an expedient laparotomy with resection of the diseased extent of bowel resection to avoid resultant short gut syndrome. intestinal segment and creation of a diverting ostomy may yield The standard of care is to remove all necrotic areas, taking great the best outcome in this subset. care to preserve any bowel that appears viable.8 After resection of the necrotic segments, an area of viable intestine is used to create an ostomy with or without a mucus fistula. There are occasional Surgical options in patients <1500 g: to drain or not to reports of primary anastomosis following resection of an isolated drain? necrotic intestinal segment; however, this is not a widely accepted In patients weighing <1500 g, the optimal choice of surgical approach.14 In patients with multiple areas of questionable intervention has been more controversial. Some surgeons argue intestinal viability, a ‘second-look’ procedure may be planned after that laparotomy with intestinal resection in VLBW infants is 24 to 48 h to reevaluate the bowel. Weber and Lewis15 reported on associated with high rates of morbidity and mortality. Therefore, 32 patients with pan-intestinal involvement and investigated the they advocate PD as the preferred initial, and sometimes definitive, impact of a second-look operation on outcome. The survival rate procedure for patients with complicated NEC or FIP.21–23 However, was 71% (10/14) for patients who underwent a second-look it is still unclear whether PD is appropriate for both NEC and FIP, procedure, and 67% (12/18) for those who did not. While this since many infants with NEC eventually require exploratory difference was not statistically significant, the principal benefit of laparotomy. In 1977, Ein et al.24 reported on a series of the second-look procedure was probably to spare marginally viable hemodynamically unstable extremely low birth weight patients who intestine. Second-look procedures have been recommended in underwent PD for NEC. Three infants survived; two of them did not concert with the ‘clip and drop back technique’.16 Proponents of require a subsequent operation. They postulated that PD allowed this approach advocate resection of the entire diseased bowel at the relief of intra-abdominal pressure, drainage of intestinal initial exploration without anastomosis, followed by reexploration perforation and time for medical optimization and stabilization. at 48 to 72 h. However, the patient sample size (five patients) is too Over the ensuing two decades, this approach has steadily gained small to comment on efficacy. Proximal diversion alone has been popularity, and many surgeons now employ it both as a shown to limit bowel resection without increasing morbidity or temporizing measure and as definitive therapy for extremely low mortality.17 In addition, second-look procedures may be of benefit birth weight patients with Bell stage III disease. In fact, Rovin in infants who are not improving 24 to 48 h after initial diversion. et al.25 advocate primary PD for all infants with stage III NEC; However, there are no randomized prospective studies comparing however, several reports note that the majority of NEC survivors this approach to others. who undergo PD eventually
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