The Role of the Microbiota-Gut-Brain Axis in Neuropsychiatric Disorders Jaqueline S
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Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress
cancers Review Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress Alexandra M. Mowday 1,2, Christopher P. Guise 1,2, David F. Ackerley 2,3, Nigel P. Minton 4, Philippe Lambin 5, Ludwig J. Dubois 5, Jan Theys 5, Jeff B. Smaill 1,2 and Adam V. Patterson 1,2,* 1 Translational Therapeutics Team, Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Auckland 1023, New Zealand; [email protected] (A.M.M.); [email protected] (C.P.G.); [email protected] (J.B.S.) 2 Maurice Wilkins Centre for Molecular Biodiscovery, School of Biological Sciences, University of Auckland, Auckland 1023, New Zealand 3 School of Biological Sciences, Victoria University of Wellington, Wellington 6140, New Zealand; [email protected] 4 The Clostridia Research Group, BBSRC/EPSRC Synthetic Biology Research Centre (SBRC) School of Life Sciences, University of Nottingham, Nottingham NG72RD, UK; [email protected] 5 Maastro (Maastricht Radiation Oncology), GROW School for Oncology and Development Biology, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands; [email protected] (P.L.); [email protected] (L.J.D.); [email protected] (J.T.) * Correspondence: [email protected]; Tel.: +64-9-923-6941 Academic Editor: Gabi Dachs Received: 16 May 2016; Accepted: 22 June 2016; Published: 28 June 2016 Abstract: Most solid cancers contain regions of necrotic tissue. The extent of necrosis is associated with poor survival, most likely because it reflects aggressive tumour outgrowth and inflammation. Intravenously injected spores of anaerobic bacteria from the genus Clostridium infiltrate and selectively germinate in these necrotic regions, providing cancer-specific colonisation. -
Probiotic and Oxytocin Combination Therapy in Patients with Autism Spectrum Disorder: a Randomized, Double-Blinded, Placebo-Controlled Pilot Trial
nutrients Article Probiotic and Oxytocin Combination Therapy in Patients with Autism Spectrum Disorder: A Randomized, Double-Blinded, Placebo-Controlled Pilot Trial Xue-Jun Kong 1,2,* , Jun Liu 1,3, Kevin Liu 1 , Madelyn Koh 1, Hannah Sherman 1, Siyu Liu 1, Ruiyi Tian 1, Piyawat Sukijthamapan 3, Jiuju Wang 1, Michelle Fong 1 , Lei Xu 3,4, Cullen Clairmont 1, Min-Seo Jeong 1, Alice Li 1, Maria Lopes 1, Veronica Hagan 1, Tess Dutton 1, Suk-Tak (Phoebe) Chan 1, Hang Lee 3,5, Amy Kendall 1, Kenneth Kwong 1 and Yiqing Song 6 1 Athinoula A. Martinos Center, Massachusetts General Hospital, Charlestown, MA 02129, USA; [email protected] (J.L.); [email protected] (K.L.); [email protected] (M.K.); [email protected] (H.S.); [email protected] (S.L.); [email protected] (R.T.); [email protected] (J.W.); [email protected] (M.F.); [email protected] (C.C.); [email protected] (M.-S.J.); [email protected] (A.L.); [email protected] (M.L.); [email protected] (V.H.); [email protected] (T.D.); [email protected] (S.-T.C.); [email protected] (A.K.); [email protected] (K.K.) 2 Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA 3 Harvard Medical School, Boston, MA 02115, USA; [email protected] (P.S.); [email protected] (L.X.); [email protected] (H.L.) 4 Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA 5 MGH Biostatistics Center, Massachusetts General Hospital, Boston, MA 02114, USA 6 Department of Epidemiology, Indiana University, Richard M. -
Chronic Administration of Probiotic L. Rhamnosus Increases Anxiety-Like Behavior in Group-Housed Male Long Evans Rats
University of Dayton eCommons Honors Theses University Honors Program 4-2018 Chronic Administration of Probiotic L. rhamnosus Increases Anxiety-like Behavior in Group-housed Male Long Evans Rats Parker Maddison Griff University of Dayton Follow this and additional works at: https://ecommons.udayton.edu/uhp_theses Part of the Biology Commons, and the Psychology Commons eCommons Citation Griff, Parker Maddison, "Chronic Administration of Probiotic L. rhamnosus Increases Anxiety-like Behavior in Group-housed Male Long Evans Rats" (2018). Honors Theses. 157. https://ecommons.udayton.edu/uhp_theses/157 This Honors Thesis is brought to you for free and open access by the University Honors Program at eCommons. It has been accepted for inclusion in Honors Theses by an authorized administrator of eCommons. For more information, please contact [email protected], [email protected]. Chronic Administration of Probiotic L. rhamnosus Increases Anxiety-like Behavior in Group-housed Male Long Evans Rats Honors Thesis Parker Maddison Griff Department: Psychology and Biology Advisor: Tracy Butler, Ph.D. and Yvonne Sun, Ph.D. April 2018 Chronic Administration of Probiotic L. rhamnosus Increases Anxiety-like Behavior in Group-housed Male Long Evans Rats Honors Thesis Parker Maddison Griff Department: Psychology and Biology Advisor: Tracy Butler, Ph.D. and Yvonne Sun, Ph.D. April 2018 Abstract Early life stress is a risk factor for later development of alcohol use disorders and anxiety disorders in humans. Using rodent experimental models, we know that rats experiencing social isolation as early-life stress exhibit greater anxiety-like behavior and alcohol consumption than rats housed in groups. Examining potential preventive strategies, we investigated the effects of probiotics, which have previously been shown to decrease rodent anxiety-like behavior, on the relationship between early-life stress and anxiety-like behavior in rats. -
Gut Microbiome in Serious Mental Illnesses: a Systematic Review and Critical Evaluation
UC San Diego UC San Diego Previously Published Works Title Gut microbiome in serious mental illnesses: A systematic review and critical evaluation. Permalink https://escholarship.org/uc/item/2nx0z5sd Authors Nguyen, Tanya T Hathaway, Hugh Kosciolek, Tomasz et al. Publication Date 2021-08-01 DOI 10.1016/j.schres.2019.08.026 Peer reviewed eScholarship.org Powered by the California Digital Library University of California SCHRES-08457; No of Pages 17 Schizophrenia Research xxx (xxxx) xxx Contents lists available at ScienceDirect Schizophrenia Research journal homepage: www.elsevier.com/locate/schres Gut microbiome in serious mental illnesses: A systematic review and critical evaluation Tanya T. Nguyen a,i,⁎, Hugh Hathaway b,c, Tomasz Kosciolek c,d, Rob Knight c,e,f,g, Dilip V. Jeste a,g,h,i a Department of Psychiatry, University of California San Diego, CA, United States of America b Medical Sciences Division, University of Oxford, Oxford, United Kingdom c Department of Pediatrics, University of California San Diego, CA, United States of America d Małopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland e Department of Computer Science and Engineering, University of California San Diego, CA, United States of America f Department of Bioengineering, University of California San Diego, CA, United States of America g Center for Microbiome Innovation, University of California San Diego, CA, United States of America h Department of Neurosciences, University of California San Diego, CA, United States of America i Sam and Rose Stein Institute for Research on Aging, University of California San Diego, CA, United States of America article info abstract Article history: Schizophrenia and bipolar disorder (BD) are associated with debilitating psychiatric and cognitive dysfunction, Received 20 June 2019 worse health outcomes, and shorter life expectancies. -
Why Multi-Collagen Protein Powder?
SLEEP APNEA solutions /// A Naturopath’s Guide to Getting off ANTIDEPRESSANTS THE SHOPPING MAGAZINE FOR NATURAL LIVING JUNE 2018 | betternutrition.com INCREDIBLE FEED BENEFITS OF YOUR GINGER EYES 12Relieve Sore Muscles * * Feel Better When Traveling * Improve Heart Health ... and more OUR 2ND ANNUAL SUMMER MEN’S MAKEOVER HEALTH SERIES & SWEEPSTAKES TUNE-UP P. 38 EASY OVERNIGHT OATS WITH FRESH BERRIES P. 54 A BUYER’S GUIDE TO COLLAGEN Essential Oils 100% Organic & Pure Why Garden of Life Essential Oils? Being both Certified USDA Organic and Non-GMO Project Verified ensures our oils are clean and free of added carrier oils or synthetic ingredients. Our botanicals are responsibly sourced from native organic farmers. And finally, our 100% pure extraction methods— Calm Yourself Recipe no chemical solvents—provide the assurance that our oils are of the Diffuse Yourself to Relax 1 highest quality, purity and efficacy. In a 1 /16 oz. dropper bottle, add 21 drops Lavender, 21 drops Sweet Orange, 12 drops Experience the aromatic essence & therapeutic benefits Frankincense, 9 drops Rosemary and 9 drops Geranium. Shake gently and add 10 drops to of the entire line of Essential Oils from Garden of Life. diffuser to relax and quiet the mind. ANCIENT NUTRITION IS BONE BROTH THE MISSING LINK TO YOUR HEALTH? For as long as humans have been cooking food over fire, bone broth—the simmering stock of bones otherwise discarded—has been a daily part of life, celebrated by cultures around the world. Not only does bone broth add depth of flavor to recipes and meals, it also imparts significant and broad health benefits that are now capturing the attention of millions. -
Clostridium Sporogenes
(R)-Indolelactyl-CoA dehydratase, the key enzyme of tryptophan reduction to indolepropionate in Clostridium sporogenes Dissertation zur Erlangung des Doktorgrades der Naturwissenschaften (Dr. rer. Nat.) dem Fachbereich Biologie der Philipps-Universität Marburg vorgelegt von Diplom-Chemikerin Huan Li aus JiLin VR. China Marburg/Lahn, 2014 Die Untersuchungen zur vorliegenden Arbeit wurden von September 2010 bis Dezember 2013 im Max-Planck-Institut für terrestrische Mikrobiologie, Marburg und im Laboratorium für Mikrobiologie, Fachbereich Biologie, der Philipps-Universität Marburg (Hochschulkennziffer: 1180) unter der Leitung von Prof. Dr. Wolfgang Buckel durchgeführt. Vom Fachbereich Biologie der Philipps-Universität Marburg als Dissertation am angenommen. Erstgutachter: Prof. Dr. Wolfgang Buckel Zweitgutachter: Prof. Dr. Johann Heider Tag der mündlichen Prüfung am: Für den gläubigen Menschen steht Gott am Anfang, für den Wissenschaftler am Ende aller seiner Überlegungen. Max Planck 献给最亲爱的爸爸妈妈 Index Zusammenfassung 1 Summary 2 Introduction 3 1. The role of gastrointestinal microbiota metabolites ........................................................... 3 2. Fermentation of amino acids and Stickland-reaction ......................................................... 5 3. Clostridium sporogenes ........................................................................................................... 7 4. 2-Hydroxyacyl-CoA dehydratases and the unusual radical H2O-elimination ................. 9 5. Family Ш CoA-transferases ............................................................................................... -
The Putative Antidepressant Mechanisms of Probiotic Bacteria: Relevant Genes and Proteins
nutrients Review The Putative Antidepressant Mechanisms of Probiotic Bacteria: Relevant Genes and Proteins Elena Poluektova 1, Roman Yunes 1,* and Valery Danilenko 1,2 1 Vavilov Institute of General Genetics, Russian Academy of Sciences, 117971 Moscow, Russia; [email protected] (E.P.); [email protected] (V.D.) 2 Faculty of Ecology, RUDN University, 117198 Moscow, Russia * Correspondence: [email protected] Abstract: Probiotic bacteria are widely accepted as therapeutic agents against inflammatory bowel diseases for their immunostimulating effects. In the last decade, more evidence has emerged sup- porting the positive effects of probiotics on the course of neurodegenerative and psychiatric diseases. This brief review summarizes the data from clinical studies of probiotics possessing antidepressant properties and focuses on the potential genes and proteins underlying these mechanisms. Data from small-sample placebo-controlled pilot studies indicate that certain strains of bacteria can significantly reduce the symptoms of depression, especially in depressed patients. Despite the disparity between studies attempting to pinpoint the bacterial putative genes and proteins accounting for these mecha- nisms, they ultimately show that bacteria are a potential source of metabiotics—microbial metabolites or structural components. Since the constituents of cells—namely, secreted proteins, peptides and cell wall components—are most likely to be entangled in the gut–brain axis, they can serve as starting point in the search for probiotics with concrete properties. Citation: Poluektova, E.; Yunes, R.; Keywords: probiotics; psychobiotics; metabiotics (postbiotics); depression Danilenko, V. The Putative Antidepressant Mechanisms of Probiotic Bacteria: Relevant Genes and Proteins. Nutrients 2021, 13, 1591. 1. Introduction https://doi.org/10.3390/nu13051591 In the last two decades, the field of human gut microbiota (HGM) has been marked by intensive and fruitful research. -
Lactobacillus Plantarum PS128 and Other Probiotics in Children and Adolescents with Autism Spectrum Disorder: a Real-World Experience
nutrients Communication Lactobacillus plantarum PS128 and Other Probiotics in Children and Adolescents with Autism Spectrum Disorder: A Real-World Experience Martina Maria Mensi 1 , Chiara Rogantini 2, Michele Marchesi 2, Renato Borgatti 1,2 and Matteo Chiappedi 1,* 1 Child Neuropsychiatry Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy; [email protected] (M.M.M.); [email protected] (R.B.) 2 Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy; [email protected] (C.R.); [email protected] (M.M.) * Correspondence: [email protected] Abstract: Autism Spectrum Disorder is a neurodevelopmental disorder. Recent data suggest that probiotics can reduce some symptoms of this disorder and Lactobacillus plantarum PS128 has been reported to be especially useful. We recruited a sample of 131 autistic children and adolescents (M:F = 122:19; age: 86.1 ± 41.1 months) and evaluated their changes after use of probiotics by mean of CGI. We found some significant improvements with very few side effects; these positive effects were more evident in younger children. Patients taking Lactobacillus plantarum PS128 had greater improvements and fewer side effects than those taking other probiotics. Our real-life data are consistent with existing literature showing a specific effect of Lactobacillus plantarum PS128 in Autism Citation: Mensi, M.M.; Rogantini, C.; Spectrum Disorder. Marchesi, M.; Borgatti, R.; Chiappedi, M. Lactobacillus plantarum PS128 and Keywords: autism spectrum disorder; probiotics; children; adolescents; Lactobacillus plantarum PS128 Other Probiotics in Children and Adolescents with Autism Spectrum Disorder: A Real-World Experience. Nutrients 2021, 13, 2036. 1. Introduction https://doi.org/10.3390/ According to the DSM 5 [1], Autism Spectrum Disorder (ASD) is diagnosed in children nu13062036 having persistent deficits in social communication and interaction across multiple contexts, and a restricted and/or repetitive pattern of behaviors, interests or activities. -
Effect of Lactobacillus Rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: a Randomised Double-Blind Placebo-Controlled Trial
EBioMedicine 24 (2017) 159–165 Contents lists available at ScienceDirect EBioMedicine journal homepage: www.ebiomedicine.com Research Paper Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial R.F. Slykerman a,F.Hoodb,K.Wickensb, J.M.D. Thompson a,C.Barthowb,R.Murphyc,J.Kangb, J. Rowden a, P. Stone d,J.Craneb, T. Stanley e,P.Abelsb,G.Purdief,R.Maudeg,E.A.Mitchella,⁎, the Probiotic in Pregnancy Study Group a Department of Paediatrics: Child and Youth Health, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand b Department of Medicine, University of Otago, P O Box 7343, Wellington, New Zealand c Department of Medicine, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand d Department of Obstetrics and Gynaecology, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand e Department of Paediatrics, University of Otago, P O Box 7343, Wellington, New Zealand f Dean's Office, University of Otago, P O Box 7343, Wellington, New Zealand g Graduate School of Nursing, Midwifery, and Health, Victoria University of Wellington, PO Box 600, Wellington 6140, New Zealand article info abstract Article history: Background: Probiotics may help to prevent symptoms of anxiety and depression through several putative mech- Received 2 July 2017 anisms. Received in revised form 31 August 2017 Objective: The aim of this study was to evaluate the effect of Lactobacillus rhamnosus HN001 (HN001) given in Accepted 13 September 2017 pregnancy and postpartum on symptoms of maternal depression and anxiety in the postpartum period. -
The Effect of Multiprobiotics on Memory and Attention in Fibromyalgia: a Pilot Randomized Controlled Trial
International Journal of Environmental Research and Public Health Article The Effect of Multiprobiotics on Memory and Attention in Fibromyalgia: A Pilot Randomized Controlled Trial Diana Cardona 1 , Pablo Roman 1,* , Fernando Cañadas 2 and Nuria Sánchez-Labraca 1 1 Department of Nursing, Physiotherapy and Medicine, Health Research Center (CEINSA), University of Almeria, 04120 Almeria, Spain; [email protected] (D.C.); [email protected] (N.S.-L.) 2 Department of Psychology, University of Almeria, 04120 Almeria, Spain; [email protected] * Correspondence: [email protected]; Tel.: +34-950214563 Abstract: Fibromyalgia syndrome (FMS) is a chronic, generalized and diffuse pain disorder accom- panied by cognitive deficits such as forgetfulness, concentration difficulties, loss of vocabulary and mental slowness, among others. In recent years, FMS has been associated with altered intestinal microbiota, suggesting that modulating gut microbiota (for example, through probiotics) could be an effective therapeutic treatment. Thus, the aim of the present study was to continue exploring the role of probiotics in cognitive processes in patients with FMS. A pilot randomized controlled trial was conducted in 31 patients diagnosed with FMS to compare the effects of a multispecies probiotic versus a placebo on cognitive variables (memory and attention) after eight weeks. Results showed that treatment with a multispecies probiotic produced an improvement in attention by reducing errors on an attention task, but it had no effect on memory. More specifically, a tendency to reduce errors of omission (Go trials) during the Go/No-Go Task was observed after treatment. These findings, along with our previous results in impulsivity, underline the relevance of using probiotics as a therapeutic Citation: Cardona, D.; Roman, P.; option in FMS, although more research with a larger sample size is required. -
Phosphate, Microbiota and CKD
nutrients Review Phosphate, Microbiota and CKD Chiara Favero 1, Sol Carriazo 1,2, Leticia Cuarental 1,2, Raul Fernandez-Prado 1,2, Elena Gomá-Garcés 1, Maria Vanessa Perez-Gomez 1,2, Alberto Ortiz 1,2,*,† , Beatriz Fernandez-Fernandez 1,2,*,† and Maria Dolores Sanchez-Niño 1,2,3,*,† 1 Department of Nephrology and Hypertension, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Av Reyes Católicos 2, 28040 Madrid, Spain; [email protected] (C.F.); [email protected] (S.C.); [email protected] (L.C.); [email protected] (R.F.-P.); [email protected] (E.G.-G.); [email protected] (M.V.P.-G.) 2 Red de Investigacion Renal (REDINREN), Av Reyes Católicos 2, 28040 Madrid, Spain 3 School of Medicine, Department of Pharmacology and Therapeutics, Universidad Autonoma de Madrid, 28049 Madrid, Spain * Correspondence: [email protected] (A.O.); [email protected] (B.F.-F.); [email protected] (M.D.S.-N.) † These authors contributed equally to this work. Abstract: Phosphate is a key uremic toxin associated with adverse outcomes. As chronic kidney dis- ease (CKD) progresses, the kidney capacity to excrete excess dietary phosphate decreases, triggering compensatory endocrine responses that drive CKD-mineral and bone disorder (CKD-MBD). Eventu- ally, hyperphosphatemia develops, and low phosphate diet and phosphate binders are prescribed. Recent data have identified a potential role of the gut microbiota in mineral bone disorders. Thus, parathyroid hormone (PTH) only caused bone loss in mice whose microbiota was enriched in the Th17 cell-inducing taxa segmented filamentous bacteria. Furthermore, the microbiota was required Citation: Favero, C.; Carriazo, S.; for PTH to stimulate bone formation and increase bone mass, and this was dependent on bacterial Cuarental, L.; Fernandez-Prado, R.; Gomá-Garcés, E.; Perez-Gomez, M.V.; production of the short-chain fatty acid butyrate. -
Microbial Tryptophan Catabolites in Health and Disease
Downloaded from orbit.dtu.dk on: Sep 27, 2021 Microbial tryptophan catabolites in health and disease Roager, Henrik Munch; Licht, Tine Rask Published in: Nature Communications Link to article, DOI: 10.1038/s41467-018-05470-4 Publication date: 2018 Document Version Publisher's PDF, also known as Version of record Link back to DTU Orbit Citation (APA): Roager, H. M., & Licht, T. R. (2018). Microbial tryptophan catabolites in health and disease. Nature Communications, 9(1). https://doi.org/10.1038/s41467-018-05470-4 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Users may download and print one copy of any publication from the public portal for the purpose of private study or research. You may not further distribute the material or use it for any profit-making activity or commercial gain You may freely distribute the URL identifying the publication in the public portal If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. REVIEW ARTICLE DOI: 10.1038/s41467-018-05470-4 OPEN Microbial tryptophan catabolites in health and disease Henrik M. Roager1,2 & Tine R. Licht 2 Accumulating evidence implicates metabolites produced by gut microbes as crucial media- tors of diet-induced host-microbial cross-talk. Here, we review emerging data suggesting that microbial tryptophan catabolites resulting from proteolysis are influencing host health.