Curriculum Vitae

PERSONAL INFORMATION Carmelo Rizzari

WORK EXPERIENCE

June 1999- Present Head of the Pediatric Hematology-Oncology Unit University of Milano Bicocca, Hospital S. Gerardo of Monza (Italy) Pediatric Hematology Oncology

June 2002-June 2009 Staff Associate Member - High Specialization University of Milano Bicocca, Hospital S. Gerardo of Monza (Italy) Pediatric Hematology Oncology

October 1990-June 2002 Staff Assistant Member University of Milano Bicocca, Hospital S. Gerardo of Monza (Italy) Pediatric Hematology-Oncology

March 1989-October 1990 Pediatrician Cinisello Balsamo, Milano (Italy)

July 1988-September 1988 Medical Service in the public area of care continuity Italian Health Service (Italy) Pediatrics

January 1988-May 1988 Medical activity of substitution for General Practitioners or Pediatricians Italian Health Service (Italy) Internal and Emergency Medicine

May 1986-September 1988 Permanent Member of the 23rd Commission (ASL Catania) for the evaluation of Civil Invalidity ASL Catania (Italy) Legal medicine and Forensic Sciensces

April 1984-October 1985 Medical Officer Italian Military Navy (Italy) Military and Emergency Medicine

EDUCATION AND TRAINING

November 1977-July 1983 Degree in Medicine and Surgery (Mentor: Prof. G. Russo, Catania) 110/110 cum laude Univerisyt of Catania, School of Medicine and Surgery (Italy) Medicine and Surgery

July 1983-November 1983 National abilitation to professional medical activities University of Catania, School of Medicine (Italy) Medicine and Surgery

July 1984-August 1984 Stage in pediatric hematology-oncology, Department of Pediatrics, Pediatric

15/12/2020 European Medicine Agency Page 1/17 hematology- Oncology Unit (Mentors: Prof. Martii Siimes, Prof. Mikko Perkkio) University of Helsinki University of Helsinki (Finland) Pediatric Hematology-Oncology

February 1985-December 1985 Employment as staff assistant member while resident in Pediatrics at the Department of Pediatrics University of Catania (Italy) Pediatric Hematology-Oncology

January 1987-September 1988 Stage in pediatric hematology-oncology, Department of Pediatrics, University of Milano, Hospital S. Gerardo of Monza (Mentor: Prof. Giuseppe Masera) . University of Milano Bicocca, Hospital S. Gerardo of Monza (Italy) Pediatric Hematology-Oncology

November 1984-July 1988 Specialization in Pediatrics (Mentor: Prof. G. Schilirò) 50/50 cum laude (Italy) Pediatric Hematology-Oncology

April 1997-October 1997 Visiting Scientist, Department of Clinical Pharmacology, St. Jude Childrens Research Hospital (Mentors: Dr. Mary V. Relling, Dr. William E. Evans), Memphis, TN, USA University of Tennessee, Memphis (United States) Pediatric Hematology-Oncology, Clinical Pharmacology

ADDITIONAL INFORMATION

Expertise Involved since the late 80ies in the field of pediatric with special expertise developed in the field of cancer chemotherapy. Currently he is the full Responsible of the Pediatric Hematology-Oncology Unit in Monza, which is the largest and first recruiting center for hematological malignancies in Italy. His main professional and scientific achievements are listed below: Participation in the development and drafting of the chemotherapy protocols adopted in Italy since the late 80ies by the AIEOP for the first-line (AIEOP LLA 91, 95, 2000) and second line (REC 98, REC 98, INTREALL) treatment of Acute Lymphoblastic . Participation in the development and drafting of the chemotherapy protocols adopted in Italy since the late 90ies by the AIEOP for the first-line (AML AIEOP 2002/01-02) and second line (IBFMSG Relapsed AML 2002 study) treatment of Acute Myeloid Leukemia. Member of the Trial Steering Committee of the currently ongoing international AIEOP-BFM ALL 2009 Study and coordinator for the pharmacological studies conducted in this trial for E.Coli PEG-ASP and Erwinia C. ASP. Major efforts have been aimed at a better management and understanding on this drug. Member of the AIEOP Trial Steering Committee for the AIEOP ALL and AML front-line and relapsed trials. He is also a member of the AIEOP committee for Myelodisplastic Syndromes. Co-cordinator since 2007 of the national protocol AIEOP ALL REC 2003 for relapsed acute lymphoblastic leukemia. Co-Principal Investigator for Italy in the European protocol IntReALL 2010 funded under the FP7 project for the European Community. In the frame of this trial he has been appointed coordinator of the european working group on studies for ASP. Principal investigator of the Italian international randomized studies AML 2001/01 (FLAG ± DaunoXome) of the International BFM Study Group. Member of the Trial Steering Committe for the upcoming european study for Relapsed AML I-BFM-SG AML Relapsed 2014. Member of the European Working Group for the design and implementation of a common european

15/12/2020 European Medicine Agency Page 2/17 protocol to be started in 2017-2018. Coordinator of the Working Group for surveillance studies of complications and toxic events in AIEOP protocols for acute lymphoblastic leukemia. Italian Principal Investigator and member of the 'European Advisory Board of the international randomized EPO-INT-51 on the role of erythropoietin Alfa in the treatment of pediatric patients with acute lymphoblastic leukemia or solid tumors. Local Principal Investigator of several Phase I-II studies on Clofarabine (Amgen), Dasatinib (Bristol Myers Squibb) Forodesine (Mundipharma), Midostaurine (Novartis), Nilotinib (Novartis), Blinatumomab (Amgen), Bortezomib (Academic Trial), NI-0501-04 (Novimmune), Volasertib (Boehringer Ingelheim), Azacytidine (Celgene). Currently he is the local PI of several additional studies with innovative drugs or strategies. "Expert Consultant" independent outside of the "Therapeutic Expert Group "for the part relating to leukemias and " within the project called "TEDDY" (acronym for Task-force in Europe for Drug Development for the Young) Since June 2010 member on behalf of the Italian centers, of the International Quality and Accreditation Committee of the european ITCC (Innovative Therapies in Children with Cancer) consortium. Since May 2012 coordinator of the AIEOP working group for Clinical Pharmacology and Pharmacovigilance. In 2013 enabled to hold the position of associate professor in the national academic selection for the General and Specialistic areas of Pediatrics (MED38). Author and coauthor of 80 publications (see attached list) in relevant, high IF scored, peer reviewed journals (Lancet, JCO, Blood, BJH, BJC, Cancer, Haematologica, Leukemia) and author of the follwinfg chapters in scientific books: Asparaginase Treatment on Treatment of acute leukemias new directions for clinical research, edited by CH Pui, Humana Press, New Jersey, 2002. Le leucemie acute in età pediatrica in Fondamenti di Oncologia Clinica, Editors. F. Cavalli, F. Cognetti A. Costa, R. Orecchia, Elsevier Italia, 2005 Chairman and speaker at several international scientific conferences and meetings (AIEOP, ASH, SIOP, IBFMSG). Data Monitoring Committee Member or Chairman for phase I-II pediatric clinical trials regarding anticancer agents and supportive therapy drugs in the field of pediatric hematology and oncology. Lecturer for students of the Medical School and for post-graduates and residents of the School of Specialization in Paediatrics Tutor, supervisor and co-rapporteur of several theses of the Medical School and of the Residency School in Pediatrics of the University of Milano Bicocca. Peer-reviewer for several scientific journals in the field of Hematology-Oncology (Haematologica, Cancer, Pediatric Blood and Cancer, Journal of Pediatric Hematology Oncology, International Journal of Pediatric Hematology and Oncology, Blood, Leukemia, Lancet Oncology, Lancet Haematology).From June 2020 holds the position of full Professor in Pediatrics at the University of Milano Biccoca, MIlano, Italy Frmo 31.12.2019 is the President Elect of the European Society of Pediatric Oncology.

Publications Khalil A, Würthwein G, Golitsch J, Hempel G, Fobker M, Gerss J, Möricke A, Zimmermann M, Smisek P, Zucchetti M, Nath C, Attarbaschi A, Von Stackelberg A, Gökbuget N, Rizzari C, Conter V, Schrappe M, Boos J, Lanvers-Kaminsky C. Pre- existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia. Haematologica. 2020 Dec 10;Online ahead of print:0. doi: 10.3324/haematol.2020.258525. PMID: 33299233 D'Angiò M, Fazio G, Grioni A, Palamini S, Sala S, Galbiati M, Biondi A, Balduzzi A, Rizzari C, Cazzaniga G. High Expression due to NRIP1/EVI1 Fusion in Therapy-related Acute Myeloid Leukemia: Description

15/12/2020 European Medicine Agency Page 3/17 of the First Pediatric Case. Hemasphere. 2020 Sep 17;4(5):e471. doi: 10.1097/HS9.0000000000000471. PMID: 33163906; PMCID: PMC7643912. Rubio-San-Simón A, André N, Cefalo MG, Aerts I, Castañeda A, Benezech S, Makin G, van Eijkelenburg N, Nysom K, Marshall L, Gambart M, Hladun R, Rossig C, Bergamaschi L, Fagioli F, Carpenter B, Ducassou S, Owens C, Øra I, Ribelles AJ, De Wilde B, Guerra-García P, Strullu M, Rizzari C, Ek T, Hettmer S, Gerber NU, Rawlings C, Diezi M, Palmu S, Ruggiero A, Verdú J, de Rojas T, Vassal G, Geoerger B, Moreno L, Bautista F. Impact of COVID-19 in paediatric early-phase cancer clinical trials in Europe: A report from the Innovative Therapies for Children with Cancer (ITCC) consortium. Eur J Cancer. 2020 Dec;141:82-91. doi: 10.1016/j.ejca.2020.09.024. Epub 2020 Oct 9. PMID: 33129040; PMCID: PMC7546235. Baruchel A, Brown P, Rizzari C, Silverman L, van der Sluis I, Wolthers BO, Schmiegelow K. Increasing completion of asparaginase treatment in childhood acute lymphoblastic leukaemia (ALL): summary of an expert panel discussion. ESMO Open. 2020 Sep;5(5):e000977. doi: 10.1136/esmoopen-2020-000977. PMID: 32967920; PMCID: PMC7513670. Saettini F, Castelli I, Provenzi M, Fazio G, Quadri M, Cazzaniga G, Sala S, Dell'Acqua F, Sieni E, Coniglio ML, Pezzoli L, Iascone M, Vendemini F, Balduzzi AC, Biondi A, Rizzari C, Bonanomi S. A novel homozygous disruptive PRF1 variant (K285Sfs*4) causes very early-onset of familial hemophagocytic lymphohystiocytosis type 2. Pediatr Hematol Oncol. 2020 Jul 22:1-5. doi: 10.1080/08880018.2020.1793849. Epub ahead of print. PMID: 32696691. Minard-Colin V, Aupérin A, Pillon M, Burke GAA, Barkauskas DA, Wheatley K, Delgado RF, Alexander S, Uyttebroeck A, Bollard CM, Zsiros J, Csoka M, Kazanowska B, Chiang AK, Miles RR, Wotherspoon A, Adamson PC, Vassal G, Patte C, Gross TG; European Intergroup for Childhood Non-Hodgkin ; Childrens Oncology Group. Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children. N Engl J Med. 2020 Jun 4;382(23):2207-2219. doi: 10.1056/NEJMoa1915315. PMID: 32492302; PMCID: PMC7720281. Ferrari A, Zecca M, Rizzari C, Porta F, Provenzi M, Marinoni M, Schumacher RF, Luksch R, Terenziani M, Casanova M, Spreafico F, Chiaravalli S, Compagno F, Bruni F, Piccolo C, Bettini L, D'Angiò M, Ferrari GM, Biondi A, Massimino M, Balduzzi A. Children with cancer in the time of COVID-19: An 8-week report from the six pediatric onco-hematology centers in Lombardia, Italy. Pediatr Blood Cancer. 2020 Aug;67(8):e28410. doi: 10.1002/pbc.28410. Epub 2020 May 26. PMID: 32452123; PMCID: PMC7267084. Locatelli F, Jordan MB, Allen C, Cesaro S, Rizzari C, Rao A, Degar B, Garrington TP, Sevilla J, Putti MC, Fagioli F, Ahlmann M, Dapena Diaz JL, Henry M, De Benedetti F, Grom A, Lapeyre G, Jacqmin P, Ballabio M, de Min C. Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis. N Engl J Med. 2020 May 7;382(19):1811-1822. doi: 10.1056/NEJMoa1911326. PMID: 32374962. Balduzzi A, Brivio E, Rovelli A, Rizzari C, Gasperini S, Melzi ML, Conter V, Biondi A. Lessons after the early management of the COVID-19 outbreak in a pediatric transplant and hemato-oncology center embedded within a COVID-19 dedicated hospital in Lombardia, Italy. Estote parati. Bone Marrow Transplant. 2020 Oct;55(10):1900-1905. doi: 10.1038/s41409-020-0895-4. Epub 2020 Apr 20. PMID: 32313181; PMCID: PMC7167532. Hrusak O, Kalina T, Wolf J, Balduzzi A, Provenzi M, Rizzari C, Rives S, Del Pozo Carlavilla M, Alonso MEV, Domínguez-Pinilla N, Bourquin JP, Schmiegelow K, Attarbaschi A, Grillner P, Mellgren K, van der Werff Ten Bosch J, Pieters R, Brozou T, Borkhardt A, Escherich G, Lauten M, Stanulla M, Smith O, Yeoh AEJ, Elitzur S, Vora A, Li CK, Ariffin H, Kolenova A, Dallapozza L, Farah R, Lazic J, Manabe A, Styczynski J, Kovacs G, Ottoffy G, Felice MS, Buldini B, Conter V,

15/12/2020 European Medicine Agency Page 4/17 Stary J, Schrappe M. Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment. Eur J Cancer. 2020 Jun;132:11-16. doi: 10.1016/j.ejca.2020.03.021. Epub 2020 Apr 7. PMID: 32305831; PMCID: PMC7141482. Würthwein G, Lanvers-Kaminsky C, Gerss J, Möricke A, Zimmermann M, Stary J, Smisek P, Attarbaschi A, Nath C, Zucchetti M, Rizzari C, Schrappe M, Boos J. Therapeutic Drug Monitoring of Asparaginase: Intra-individual Variability and Predictivity in Children With Acute Lymphoblastic Leukemia Treated With PEG- Asparaginase in the AIEOP-BFM Acute Lymphoblastic Leukemia 2009 Study. Ther Drug Monit. 2020 Jun;42(3):435-444. doi: 10.1097/FTD.0000000000000727. PMID: 32022785. Attarbaschi A, Mann G, Zimmermann M, Bader P, Barisone E, Basso G, Biondi A, Cario G, Cazzaniga G, Colombini A, Flotho C, Kuhlen M, Lang P, Lauten M, Linderkamp C, Locatelli F, Lo Nigro L, Möricke A, Niggli F, Panzer-Grümayer R, Parasole R, Peters C, Caterina Putti M, Rizzari C, Suttorp M, Valsecchi MG, Conter V, Schrappe M; on behalf of the AIEOP-BFM (Associazione Italiana di Ematologia e Oncologia Pediatrica & Berlin-Frankfurt-Münster) Study Group. Randomized post-induction and delayed intensification therapy in high-risk pediatric acute lymphoblastic leukemia: long-term results of the international AIEOP-BFM ALL 2000 trial. Leukemia. 2020 Jun;34(6):1694-1700. doi: 10.1038/s41375-019-0670-y. Epub 2019 Dec 5. PMID: 31806872. Hijiya N, Zwaan CM, Rizzari C, Foà R, Abbink F, Lancaster D, Landman-Parker J, Millot F, Moppett J, Nelken B, Caterina Putti M, Tian X, Sinclair K, Santanastasio H, Buchbinder A, Kearns P. Pharmacokinetics of Nilotinib in Pediatric Patients with -Positive Chronic Myeloid Leukemia or Acute Lymphoblastic Leukemia. Clin Cancer Res. 2020 Feb 15;26(4):812-820. doi: 10.1158/1078-0432.CCR-19-0090. Epub 2019 Nov 1. PMID: 31676669. Attarbaschi A, Mann G, Zimmermann M, Bader P, Barisone E, Basso G, Biondi A, Cario G, Cazzaniga G, Colombini A, Flotho C, Kuhlen M, Lang P, Lauten M, Linderkamp C, Locatelli F, Lo Nigro L, Möricke A, Niggli F, Panzer-Grümayer R, Parasole R, Peters C, Caterina Putti M, Rizzari C, Suttorp M, Valsecchi MG, Conter V, Schrappe M; on behalf of the AIEOP-BFM (Associazione Italiana di Ematologia e Oncologia Pediatrica & Berlin-Frankfurt-Münster) Study Group. Randomized post-induction and delayed intensification therapy in high-risk pediatric acute lymphoblastic leukemia: long-term results of the international AIEOP-BFM ALL 2000 trial. Leukemia. 2020 Jun;34(6):1694-1700. doi: 10.1038/s41375-019-0670-y. Epub 2019 Dec 5. PMID: 31806872. Hijiya N, Zwaan CM, Rizzari C, Foà R, Abbink F, Lancaster D, Landman-Parker J, Millot F, Moppett J, Nelken B, Caterina Putti M, Tian X, Sinclair K, Santanastasio H, Buchbinder A, Kearns P. Pharmacokinetics of Nilotinib in Pediatric Patients with Philadelphia Chromosome-Positive Chronic Myeloid Leukemia or Acute Lymphoblastic Leukemia. Clin Cancer Res. 2020 Feb 15;26(4):812-820. doi: 10.1158/1078-0432.CCR-19-0090. Epub 2019 Nov 1. PMID: 31676669. Bautista F, Engelhard D, Rizzari C, Baka M, Saavedra-Lozano J, Lopez-Medina E, Nasmyth-Miller C, Hernández-Sánchez J, Sturm S. Pharmacokinetics and Pharmacodynamics of Conventional-Dose vs Triple-Dose Oseltamivir in Severely Immunocompromised Children With Influenza. Open Forum Infect Dis. 2019 Oct 23;6(10):ofz430. doi: 10.1093/ofid/ofz430. PMID: 31660381; PMCID: PMC6809794. Testi AM, Attarbaschi A, Valsecchi MG, Möricke A, Cario G, Niggli F, Silvestri D, Bader P, Kuhlen M, Parasole R, Putti MC, Lang P, Flotho C, Mann G, Rizzari C, Barisone E, Locatelli F, Linderkamp C, Lauten M, Suttorp M,

15/12/2020 European Medicine Agency Page 5/17 Zimmermann M, Basso G, Biondi A, Conter V, Schrappe M; AIEOP-BFM (Associazione Italiana di Ematologia e Oncologia Pediatrica & Berlin-Frankfurt-Münster) Study Group. Outcome of adolescent patients with acute lymphoblastic leukaemia aged 10-14 years as compared with those aged 15-17 years: Long-term results of 1094 patients of the AIEOP-BFM ALL 2000 study. Eur J Cancer. 2019 Nov;122:61-71. doi: 10.1016/j.ejca.2019.09.004. Epub 2019 Oct 17. PMID: 31629941. Peri AM, Verna M, Biffi S, Alagna L, Longhi B, Migliorino GM, Foresti S, Bandera A, Rovelli A, Rizzari C, Gori A, Colombini A. Combination Antifungal Therapy for Invasive Mold Infections Among Pediatric Patients with Hematological Malignancies: Data from A Real-Life Case-Series. Pathog Immun. 2019 Sep 5;4(2):180-194. doi: 10.20411/pai.v4i2.299. PMID: 31538132; PMCID: PMC6742350. Hijiya N, Maschan A, Rizzari C, Shimada H, Dufour C, Goto H, Kang HJ, Guinipero T, Karakas Z, Bautista F, Ducassou S, Yoo KH, Zwaan CM, Millot F, Aimone P, Allepuz A, Quenet S, Hourcade-Potelleret F, Hertle S, Sosothikul D. Phase 2 study of nilotinib in pediatric patients with Philadelphia chromosome- positive chronic myeloid leukemia. Blood. 2019 Dec 5;134(23):2036-2045. doi: 10.1182/blood.2019000069. PMID: 31511239; PMCID: PMC6923664. Michelozzi IM, Granata V, De Ponti G, Alberti G, Tomasoni C, Antolini L, Gambacorti-Passerini C, Gentner B, Dazzi F, Biondi A, Coliva T, Rizzari C, Pievani A, Serafini M. Acute myeloid leukaemia niche regulates response to L-asparaginase. Br J Haematol. 2019 Aug;186(3):420-430. doi: 10.1111/bjh.15920. Epub 2019 May 1. PMID: 31044436 Spreafico F, Quarello P, Alaggio R, Collini P, Haupt R, Mastronuzzi A, Prete A, Rabusin M, Rizzari C, Schumacher F, Zecca M, Pession A, Fagioli F. Nationwide central diagnosis review for childhood solid tumors: From concept to realization of an Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) integrated project. Pediatr Blood Cancer. 2019 Aug;66(8):e27749. doi: 10.1002/pbc.27749. Epub 2019 Apr 17. PMID: 30997709. Dell'Acqua F, Saettini F, Castelli I, Badolato R, Notarangelo LD, Rizzari C. Hermansky-Pudlak syndrome type II and lethal hemophagocytic lymphohistiocytosis: Case description and review of the literature. J Allergy Clin Immunol Pract. 2019 Sep-Oct;7(7):2476-2478.e5. doi: 10.1016/j.jaip.2019.04.001. Epub 2019 Apr 8. PMID: 30974211. Fazio G, Massa V, Grioni A, Bystry V, Rigamonti S, Saitta C, Galbiati M, Rizzari C, Consarino C, Biondi A, Selicorni A, Cazzaniga G. First evidence of a paediatric patient with Cornelia de Lange syndrome with acute lymphoblastic leukaemia. J Clin Pathol. 2019 Aug;72(8):558-561. doi: 10.1136/jclinpath-2019-205707. Epub 2019 Apr 4. PMID: 30948435. Parasole R, Valsecchi MG, Silvestri D, Locatelli F, Barisone E, Petruzziello F, Putti MC, Micalizzi C, Colombini A, Mura R, Mina T, Testi AM, Notarangelo LD, Santoro N, Casini T, Consarino C, Nigro LL, Ziino O, Giagnuolo G, Rizzari C, Conter V. Correspondence: Osteonecrosis in childhood acute lymphoblastic leukemia: a retrospective cohort study of the Italian Association of Pediatric Haemato-Oncology (AIEOP). Blood Cancer J. 2018 Nov 15;8(12):115. doi: 10.1038/s41408-018-0150-z. PMID: 30442887; PMCID: PMC6237817. Portale F, Cricrì G, Bresolin S, Lupi M, Gaspari S, Silvestri D, Russo B, Marino N, Ubezio P, Pagni F, Vergani P, Kronnie GT, Valsecchi MG, Locatelli F, Rizzari C, Biondi A, Dander E, D'Amico G. ActivinA: a new leukemia-promoting factor conferring migratory advantage to B-cell precursor-acute lymphoblastic leukemic cells. Haematologica. 2019 Mar;104(3):533-545. doi: 10.3324/haematol.2018.188664. Epub 2018 Sep 27. PMID: 30262563; PMCID: PMC6395324. Zwaan CM, Söderhäll S, Brethon B, Luciani M, Rizzari C, Stam RW, Besse E,

15/12/2020 European Medicine Agency Page 6/17 Dutreix C, Fagioli F, Ho PA, Dufour C, Pieters R. A phase 1/2, open-label, dose- escalation study of midostaurin in children with relapsed or refractory acute leukaemia. Br J Haematol. 2019 May;185(3):623-627. doi: 10.1111/bjh.15593. Epub 2018 Sep 11. PMID: 30203832. Saettini F, Moratto D, Grioni A, Maitz S, Iascone M, Rizzari C, Pavan F, Spinelli M, Bettini LR, Biondi A, Badolato R. A novel EP300 associated with Rubinstein-Taybi syndrome type 2 presenting as combined immunodeficiency. Pediatr Allergy Immunol. 2018 Nov;29(7):776-781. doi: 10.1111/pai.12968. Epub 2018 Sep 28. PMID: 30076641. Rizzari C. Inotuzumab ozogamicin in older patients with acute lymphoblastic leukaemia: premises and promises. Lancet Oncol. 2018 Feb;19(2):159-160. doi: 10.1016/S1470-2045(18)30013-5. Epub 2018 Jan 16. PMID: 29352702. Lanvers-Kaminsky C, Rüffer A, Würthwein G, Gerss J, Zucchetti M, Ballerini A, Attarbaschi A, Smisek P, Nath C, Lee S, Elitzur S, Zimmermann M, Möricke A, Schrappe M, Rizzari C, Boos J. Therapeutic Drug Monitoring of Asparaginase Activity-Method Comparison of MAAT and AHA Test Used in the International AIEOP- BFM ALL 2009 Trial. Ther Drug Monit. 2018 Feb;40(1):93-102. doi: 10.1097/FTD.0000000000000472. PMID: 29210976. Schrappe M, Bleckmann K, Zimmermann M, Biondi A, Möricke A, Locatelli F, Cario G, Rizzari C, Attarbaschi A, Valsecchi MG, Bartram CR, Barisone E, Niggli F, Niemeyer C, Testi AM, Mann G, Ziino O, Schäfer B, Panzer-Grümayer R, Beier R, Parasole R, Göhring G, Ludwig WD, Casale F, Schlegel PG, Basso G, Conter V. Reduced-Intensity Delayed Intensification in Standard-Risk Pediatric Acute Lymphoblastic Leukemia Defined by Undetectable Minimal Residual Disease: Results of an International Randomized Trial (AIEOP-BFM ALL 2000). J Clin Oncol. 2018 Jan 20;36(3):244-253. doi: 10.1200/JCO.2017.74.4946. Epub 2017 Nov 17. PMID: 29148893. Zampini M, Bisio V, Leszl A, Putti MC, Menna G, Rizzari C, Pession A, Locatelli F, Basso G, Tregnago C, Pigazzi M. A three-miRNA-based expression signature at diagnosis can predict occurrence of relapse in children with t(8;21) RUNX1-RUNX1T1 acute myeloid leukaemia. Br J Haematol. 2018 Schrappe M, Bleckmann K, Zimmermann M, Biondi A, Möricke A, Locatelli F, Cario G, Rizzari C, Attarbaschi A, Valsecchi MG, Bartram CR, Barisone E, Niggli F, Niemeyer C, Testi AM, Mann G, Ziino O, Schäfer B, Panzer-Grümayer R, Beier R, Parasole R, Göhring G, Ludwig WD, Casale F, Schlegel PG, Basso G, Conter V. Reduced-Intensity Delayed Intensification in Standard-Risk Pediatric Acute Lymphoblastic Leukemia Defined by Undetectable Minimal Residual Disease: Results of an International Randomized Trial (AIEOP-BFM ALL 2000). J Clin Oncol. 2018 Jan 20;36(3):244-253. doi: 10.1200/JCO.2017.74.4946. Epub 2017 Nov 17. PMID: 29148893. Zampini M, Bisio V, Leszl A, Putti MC, Menna G, Rizzari C, Pession A, Locatelli F, Basso G, Tregnago C, Pigazzi M. A three-miRNA-based expression signature at diagnosis can predict occurrence of relapse in children with t(8;21) RUNX1-RUNX1T1 acute myeloid leukaemia. Br J Haematol. 2018 Oct;183(2):298-301. doi: 10.1111/bjh.14950. Epub 2017 Sep 29. PMID: 28961307. Locatelli F, Valsecchi MG, Möricke A, Zimmermann M, Gruhn B, Biondi A, Kulozik AE, Silvestri D, Bodmer N, Putti MC, Burdach S, Micalizzi C, Teigler- Schlegel A, Ritter J, Pession A, Cario G, Bielack S, Basso G, Klingebiel T, Vinti L, Rizzari C, Attarbaschi A, Santoro N, Parasole R, Mann G, Karawajew L, Haas OA, Conter V, Schrappe M. Protocol II vs protocol III given twice during reinduction therapy in children with medium-risk ALL. Blood. 2017 Nov 9;130(19):2146-2149. doi: 10.1182/blood-2017-05-782086. Epub 2017 Sep 22. PMID: 28939722.

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15/12/2020 European Medicine Agency Page 14/17 Rizzari C, Biondi A. Genotypes of the glutathione S-transferase superfamily do not correlate with outcome of childhood acute lymphoblastic leukemia. Leukemia. 2003 May;17(5):981-3. PubMed PMID: 12750715. Arrigoni P, Beretta C, Silvestri D, Rossi V, Rizzari C, Valsecchi MG, Cazzaniga G, Biondi A. FLT3 internal tandem duplication in childhood acute myeloid leukaemia: association with hyperleucocytosis in acute promyelocytic leukaemia. Br J Haematol. 2003 Jan;120(1):89-92. PubMed PMID: 12492581. Aricò M, Valsecchi MG, Conter V, Rizzari C, Pession A, Messina C, Barisone E, Poggi V, De Rossi G, Locatelli F, Micalizzi MC, Basso G, Masera G. Improved outcome in high-risk childhood acute lymphoblastic leukemia defined by prednisone-poor response treated with double Berlin-Frankfurt-Muenster protocol II. Blood. 2002 Jul 15;100(2):420-6. PubMed PMID: 12091331. Rizzari C, Valsecchi MG, Aricò M, Conter V, Testi A, Barisone E, Casale F, Lo Nigro L, Rondelli R, Basso G, Santoro N, Masera G; Associazione Italiano Ematologia Oncologia Pediatrica. Effect of protracted high-dose L-asparaginase given as a second exposure in a Berlin-Frankfurt-Münster-based treatment: results of the randomized 9102 intermediate-risk childhood acute lymphoblastic leukemia study--a report from the Associazione Italiana Ematologia Oncologia Pediatrica. J Clin Oncol. 2001 Mar 1;19(5):1297-303. PubMed PMID: 11230471. Conter V, Aricò M, Valsecchi MG, Basso G, Biondi A, Madon E, Mandelli F, Paolucci G, Pession A, Rizzari C, Rondelli R, Zanesco L, Masera G. Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) acute lymphoblastic leukemia studies, 1982-1995. Leukemia. 2000 Dec;14(12):2196-204. PubMed PMID: 11187911. Rizzari C, Zucchetti M, Conter V, Diomede L, Bruno A, Gavazzi L, Paganini M, Sparano P, Lo Nigro L, Aricò M, Milani M, D'Incalci M. L-asparagine depletion and L-asparaginase activity in children with acute lymphoblastic leukemia receiving i.m. or i.v. Erwinia C. or E. coli L-asparaginase as first exposure. Ann Oncol. 2000 Feb;11(2):189-93. PubMed PMID: 10761754. Riva L, Conter V, Rizzari C, Jankovic M, Sala A, Milani M. Successful treatment of intrathecal methotrexate overdose with folinic acid rescue: a case report. Acta Paediatr. 1999 Jul;88(7):780-2. Review. PubMed PMID: 10447141. Rizzari C, Malberti R, Dell'Orto M, Milani M, Jankovic M, Ferrari E, Conter V. Transient myeloproliferative disorder associated with 21: is a short course of chemotherapy indicated in patients with liver impairment and severe clinical problems? Med Pediatr Oncol. 1999 Jun;32(6):453-4. PubMed PMID: 10358708.

Conter V, Aricò M, Valsecchi MG, Rizzari C, Testi A, Miniero R, Di Tullio MT, Lo Nigro L, Pession A, Rondelli R, Messina C, Santoro N, Mori PG, De Rossi G, Tamaro P, Silvestri D, Biondi A, Basso G, Masera G. Intensive BFM chemotherapy for childhood ALL: interim analysis of the AIEOP-ALL 91 study. Associazione Italiana Ematologia Oncologia Pediatrica. Haematologica. 1998 Sep;83(9):791-9. PubMed PMID: 9825576. Rizzari C, Conter V. Bone marrow biopsy as prognostic indicator in childhood acute lymphoblastic leukemia--another opinion. Med Pediatr Oncol. 1998 May;30(5):315-7. PubMed PMID: 9544233. Rizzari C, Valsecchi MG, Conter V. MTHFR 677C-->T mutation and neural-tube defects. Lancet. 1997 Nov 15;350(9089):1479-80. PubMed PMID: 9371193. Conter V, Schrappe M, Aricó M, Reiter A, Rizzari C, Dördelmann M, Valsecchi MG, Zimmermann M, Ludwig WD, Basso G, Masera G, Riehm H. Role of cranial radiotherapy for childhood T-cell acute lymphoblastic leukemia with high WBC count and good response to prednisone. Associazione Italiana Ematologia Oncologia

15/12/2020 European Medicine Agency Page 15/17 Pediatrica and the Berlin-Frankfurt-Münster groups. J Clin Oncol. 1997 Aug;15(8):2786-91. PubMed PMID: 9256120. Gentili D, Conter V, Rizzari C, Tschuemperlin B, Zucchetti M, Orlandoni D, D'Incalci M, Masera G. L-Asparagine depletion in plasma and cerebro-spinal fluid of children with acute lymphoblastic leukemia during subsequent exposures to Erwinia L-asparaginase. Ann Oncol. 1996 Sep;7(7):725-30. PubMed PMID: 8905031. Rizzari C, Conter V. Rothmund-Thomson syndrome, malignant diseases, and treatment opportunities. Pediatr Hematol Oncol. 1996 Mar-Apr;13(2):195-6. PubMed PMID: 8721038. Conter V, D'Angelo P, Rizzari C, Jankovic M, Dampier C, Masera G, Johnson FL. High-dose cytosine arabinoside and fractionated total body irradiation as a preparative regimen for the treatment of children with acute lymphoblastic leukemia and by allogeneic bone marrow transplantation. Bone Marrow Transplant. 1996 Feb;17(2):287-9. PubMed PMID: 8640182. Rizzari C, Bacchiocchi D, Rovelli A, Biondi A, Cantu'-Rajnoldi A, Uderzo C, Masera G. Myelodysplastic syndrome in a child with Rothmund-Thomson syndrome: a case report. J Pediatr Hematol Oncol. 1996 Feb;18(1):96-7. PubMed PMID: 8556381. Conter V, Aricò M, Valsecchi MG, Rizzari C, Testi AM, Messina C, Mori PG, Miniero R, Colella R, Basso G, et al. Extended intrathecal methotrexate may replace cranial irradiation for prevention of CNS relapse in children with intermediate-risk acute lymphoblastic leukemia treated with Berlin-Frankfurt-Münster-based intensive chemotherapy. The Associazione Italiana di Ematologia ed Oncologia Pediatrica. J Clin Oncol. 1995 Oct;13(10):2497-502. PubMed PMID: 7595699. Rizzari C, Conter V. "Childhood ALL and cystic fibrosis--treatment and outcome". Med Pediatr Oncol. 1995 Sep;25(3):223. PubMed PMID: 7623733. Barzaghi A, Dell'Orto M, Rovelli A, Rizzari C, Colombini A, Uderzo C. Central venous catheter clots: incidence, clinical significance and catheter care in patients with hematologic malignancies. Pediatr Hematol Oncol. 1995 May-Jun;12(3):243-50. PubMed PMID: 7640177. Aricò M, Basso G, Mandelli F, Rizzari C, Colella R, Barisone E, Zanesco L, Rondelli R, Pession A, Masera G. Good steroid response in vivo predicts a favorable outcome in children with T-cell acute lymphoblastic leukemia. The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP). Cancer. 1995 Apr 1;75(7):1684-93. PubMed PMID: 8826928. Rizzari C, Conter V, D'Angelo P, Cantù-Rajnoldi A, Masera G. Efficacy of prolonged low-dose steroid treatment in a child with idiopathic hypereosinophilic syndrome: a case report. Pediatr Hematol Oncol. 1995 Mar-Apr;12(2):209-12. PubMed PMID: 7626393. D'Angelo P, Mura R, Rizzari C, Conter V, Bellini F, Valsecchi MG, Manganini C, Silvestri D, Masera G. Prognostic value of nephromegaly at diagnosis of childhood acute lymphoblastic leukemia. Acta Haematol. 1995;94(2):84-9. PubMed PMID: 7484018. D'Angelo P, Conter V, Di Chiara G, Rizzari C, Memeo A, Barigozzi P. Severe osteoporosis and multiple vertebral collapses in a child during treatment for B-ALL. Acta Haematol. 1993;89(1):38-42. PubMed PMID: 8480485. Rovelli A, Biondi A, Cantù Rajnoldi A, Conter V, Giudici G, Jankovic M, Locasciulli A, Rizzari C, Romitti L, Rossi MR, et al. Microgranular variant of acute promyelocytic leukemia in children. J Clin Oncol. 1992 Sep;10(9):1413-8. PubMed PMID: 1517784.

Rizzari C, Conter V, Jankovic M, D'Angelo P, Masera G, Costantini D, Bettinelli ME, Giunta AM. Acute lymphoblastic leukaemia in a child with cystic fibrosis. Haematologica. 1992 Sep-Oct;77(5):427-9. Review. PubMed PMID: 1483594.

15/12/2020 European Medicine Agency Page 16/17 Mura R, D'Angelo P, Rizzari C, Biondi A, Giudici G, Crosti L, Castagni M, Cantu'-Rajnoldi A. Lineage switch in a childhood T-cell acute lymphoblastic leukemia. Pediatr Hematol Oncol. 1992 Jul-Sep;9(3):281-8. PubMed PMID: 1525008. Rizzari C, Palamone G, Corbetta A, Uderzo C, Viganò EF, Codecasa G. Central venous catheter-related infections in pediatric hematology-oncology patients: role of home and hospital management. Pediatr Hematol Oncol. 1992 Apr-Jun;9(2):115-23. PubMed PMID: 1524988. Uderzo C, D'Angelo P, Rizzari C, Viganò EF, Rovelli A, Gornati G, Codecasa G, Locasciulli A, Masera G. Central venous catheter-related complications after bone marrow transplantation in children with hematological malignancies. Bone Marrow Transplant. 1992 Feb;9(2):113-7. PubMed PMID: 1571709. Rizzari C, Conter V, Jankovic M, Uderzo C, Masera G, Cappellini A, Rajnoldi AC. Isolated muscular relapse in a child with B-acute lymphoblastic leukemia, o therapy. Pediatr Hematol Oncol. 1991 Jul-Sep;8(3):263-7. PubMed PMID: 1742186 Schiliro G, Rizzari C, Testa R, Lo Faro F, Comisi FF, Russo A. Association of Hb S [beta 6(A3)Glu----Val] and Hb I-interlaken [alpha 15(A13)Gly----Asp] in a Sicilian man; review of the occurrence of Hb I-interlaken in Sicily. Hemoglobin. 1989;13(4):403-10. Review. PubMed PMID: 2666359. Rizzari C, Santamaria M, Galli MA, Jankovic M, Uderzo C. [Early daunorubicin cardiotoxicity and fatal outcome in a child with acute myeloblastic leukemia (M2)]. Pediatr Med Chir. 1987 Nov-Dec;9(6):749-50. Italian. PubMed PMID: 3481847. Russo A, Di Bella D, Lo Bianco M, Rizzari C, Schilirò G. Convulsions and intracranial calcifications in a leukemic infant receiving only intrathecal methotrexate as central nervous system prophylaxis. Pediatr Hematol Oncol. 1987;4(3):269-72. PubMed PMID: 3152931. Russo A, Tomarchio S, Pero G, Consoli G, Marina R, Rizzari C, Schilirò G. Abnormal visual-evoked potentials in leukemic children after cranial radiation. Med Pediatr Oncol. 1985;13(6):313-7. PubMed PMID: 3862934.

Projects See the expertise section for a thorough description

Memberships Active member of the following scientific societies/networks/consortia: AIEOP, IBFMSG, ITCC, SIOP.

Other Relevant Information All information is included in the Expertise section

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