Supplementary Information for the Crebbp Acetyltransferase Is A
Supplementary Information for The Crebbp acetyltransferase is a haploinsufficient tumor suppressor in B cell lymphoma Jiyuan Zhang1, Sofija Vlasevska1, Victoria A. Wells1, Sarah Nataraj1, Antony B. Holmes1, Romain Duval1, Stefanie N. Meyer1, Tongwei Mo1, Katia Basso1,2, Paul K Brindle3, Shafinaz Hussein4, Riccardo Dalla-Favera1,2,5,6,7 and Laura Pasqualucci1,2,7* 1 Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA 2 Department of Pathology and Cell Biology, Columbia University, New York, NY, 10032, USA 3 Department of Biochemistry, St. Jude Children’s Research Hospital, Memphis, TN 4 Department of Pathology and Laboratory Medicine, NorthWell Health, Staten Island University Hospital, Staten Island, New York, USA 5 Department of Genetics & Development, Columbia University, New York, NY, 10032, USA 6 Department of Microbiology & Immunology, Columbia University, New York, NY, 10032, USA 7 Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 10032, USA *Correspondence: lp171@columbia.edu SI Guide Supplementary Figure S1. CREBBP binds to GC-specific super-enhancers Supplementary Figure S2. Crebbp and EP300 expression in the B cell lineage Supplementary Figure S3. GSEA of Crebbp-conditional knock-out GC B cells and human DZ vs LZ B cells Supplementary Figure S4. Analysis of GC B cell responses in Crebbpfl/fl Cγ1-Cre and CD19-Cre cohorts Supplementary Figure S5. Analysis of plasma cell differentiation in Crebbpfl/fl Cγ1-Cre and CD19-Cre cohorts Supplementary Figure S6. Distribution pattern of CREBBP mutations in FL and de novo DLBCL Supplementary Figure S7. Analysis of Crebbp conditional knock-out tumor cohorts Supplementary Table S1. Overlap between CREBBP bound regions and predicted super- enhancers in GC B cells Supplementary Table S2.
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