ACVR1 Polyclonal Antibody

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ACVR1 polyclonal antibody heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II Catalog Number: PAB2638 and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding Regulatory Status: For research use only (RUO) extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with Product Description: Rabbit polyclonal antibody raised predicted serine/threonine specificity. Type I receptors against synthetic peptide of ACVR1. are essential for signaling; and type II receptors are required for binding ligands and for expression of type I Immunogen: A synthetic peptide (conjugated with KLH) receptors. Type I and II receptors form a stable complex corresponding to internal region of human ACVR1. after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin Host: Rabbit A type I receptor which signals a particular Reactivity: Human transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with Applications: IHC-P, WB-Tr fibrodysplasia ossificans progressive. [provided by (See our web site product page for detailed applications RefSeq] information) References: Protocols: See our web site at 1. Inhibin, activin, follistatin, activin receptors and http://www.abnova.com/support/protocols.asp or product beta-glycan gene expression in the placental tissue of page for detailed protocols patients with pre-eclampsia. Casagrandi D, Bearfield C, Geary J, Redman CW, Muttukrishna S. Mol Hum Form: Liquid Reprod. 2003 Apr;9(4):199-203. 2. The physiology and pathophysiology of inhibin, activin Purification: Ammonium sulfate precipitation and follistatin in female reproduction. Welt CK. Curr Opin Obstet Gynecol. 2002 Jun;14(3):317-23. Recommend Usage: Western Blot (1:1000) 3. The distribution of activin and activin receptors in Immunohistochemistry (1:50-100) gestational tissues across human pregnancy and during The optimal working dilution should be determined by labour. Schneider-Kolsky ME, Manuelpillai U, Waldron the end user. K, Dole A, Wallace EM. Placenta. 2002 Apr;23(4):294-302. Storage Buffer: In PBS (0.09% sodium azide) Storage Instruction: Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. Entrez GeneID: 90 Gene Symbol: ACVR1 Gene Alias: ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI Gene Summary: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a Page 1/1 Powered by TCPDF (www.tcpdf.org).

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Access AMH Instructions for Use Anti-Müllerian Hormone (AMH) © 2017 Beckman Coulter, Inc
ACCESS Immunoassay Systems Access AMH Instructions For Use Anti-Müllerian hormone (AMH) © 2017 Beckman Coulter, Inc. All rights reserved. B13127 FOR PROFESSIONAL USE ONLY Rx Only ANNUAL REVIEW Reviewed by Date Reviewed by Date PRINCIPLE INTENDED USE The Access AMH assay is a paramagnetic particle chemiluminescent immunoassay for the quantitative determination of anti-Müllerian hormone (AMH) levels in human serum and lithium heparin plasma using the Access Immunoassay Systems as an aid in the assessment of ovarian reserve in women presenting to fertility clinics. This system is intended to distinguish between women presenting with AFC (antral follicle count) values > 15 (high ovarian reserve) and women with AFC values ≤ 15 (normal or diminished ovarian reserve). The Access AMH is intended to be used in conjunction with other clinical and laboratory findings such as antral follicle count, before starting fertility therapy. The Access AMH is not intended to be used for monitoring of women undergoing controlled ovarian stimulation in an Assisted Reproduction Technology program. SUMMARY AND EXPLANATION Anti-Müllerian hormone (AMH) is a glycoprotein, which circulates as a dimer composed of two identical 72 kDa monomers that are linked by disulfide bridges. AMH belongs to the transforming growth factor-β family.1,2 AMH is named for its first described function in fetal sexual differentiation: a regression of the Müllerian ducts in males during early fetal life. In males, AMH is secreted by Sertoli cells of the testes. AMH concentrations are high
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Follistatin and Noggin Are Excluded from the Zebrafish Organizer
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Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-Β
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Lack of Tgfbr1 and Acvr1b Synergistically Stimulates Myofibre Hypertrophy And
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Long-Term Enhancement of Skeletal Muscle Mass and Strength by Single Gene Administration of Myostatin Inhibitors
Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors Amanda M. Haidet*†, Liza Rizo*, Chalonda Handy*†, Priya Umapathi*, Amy Eagle*, Chris Shilling*, Daniel Boue*, Paul T. Martin*†‡, Zarife Sahenk*†‡, Jerry R. Mendell*‡, and Brian K. Kaspar*†‡§ *The Research Institute, Nationwide Children’s Hospital, Columbus, OH 43205; and †Integrated Biomedical Science and ‡Neuroscience Graduate Programs, Ohio State University, Columbus, OH 43210 Edited by Joshua R. Sanes, Harvard University, Cambridge, MA, and approved February 5, 2008 (received for review September 25, 2007) Increasing the size and strength of muscles represents a promising capable of controlling muscle mass through pathways indepen- therapeutic strategy for musculoskeletal disorders, and interest dent of the myostatin signaling cascade. In these studies, myo- has focused on myostatin, a negative regulator of muscle growth. statin knockout mice were crossed to mice carrying a follistatin Various myostatin inhibitor approaches have been identiﬁed and transgene. The resulting mice had a quadrupling of muscle mass tested in models of muscle disease with varying efﬁcacies, depend- compared with the doubling of muscle mass that is observed ing on the age at which myostatin inhibition occurs. Here, we from lack of myostatin alone, confirming a role for follistatin in describe a one-time gene administration of myostatin-inhibitor- the regulation of muscle mass beyond solely myostatin inhibition proteins to enhance muscle mass and strength in normal and (15). In addition to follistatin, two other proteins have been dystrophic mouse models for >2 years, even when delivered in identified that are involved in the regulation of the myostatin.
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BMP Signaling in the Development of the Mouse Esophagus and Forestomach Pavel Rodriguez1, Susana Da Silva1, Leif Oxburgh2, Fan Wang1, Brigid L
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Functional Redundancy of Type I and Type II Receptors in the Regulation Of
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Targeting Follistatin Like 1 Ameliorates Liver Fibrosis Induced by Carbon
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