The Bitterest Pills Also by Joanna Moncrieff the MYTH of the CHEMICAL CURE
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The Bitterest Pills Also by Joanna Moncrieff THE MYTH OF THE CHEMICAL CURE DE-MEDICALISING MISERY (co-editor) A STRAIGHT TALKING INTRODUCTION TO PSYCHIATRIC DRUGS Praise for The Myth of the Chemical Cure: ‘A revolutionary book written with the calm assurance of someone who knows her subject matter – and the people involved – extremely well. Essential reading for anyone interested in mental health’. Dorothy Rowe, www.dorothyrowe.com.au ‘This is a book that should change psychiatry forever’. Mental Health ‘This book is critically important and should be essential reading for all psy- chiatrists, politicians, service providers, and user groups. Why? Because Joanna Moncrieff’s central tenet is right, and the implications for service delivery are profound. The book is closely argued and well referenced. Even if you disagree with some of it’s overall premises, it is not legitimate to dismiss it. I urge you to read it if only as a prompt to a critical evaluation of the status quo, never a bad thing, and almost always an illuminating exercise’. Sarah Yates, Cambridge, UK ‘This is a sober and thoughtful book. I found it very engaging and worth the effort to be better informed about a subject that affects many of our clients and impinges on our professional lives as therapists’. Existential Analysis (Society for Existential Analysis) ‘...Joanna Moncrieff, a practising psychiatrist and academic, has produced a devastating critique of the use of psychiatric drugs... This courageous book has the potential to revolutionise psychiatric practice and the care of people with many forms of mental distress. Many in the therapy professions will, I am sure, celebrate its message’. Rachel Freeth, Therapy Today This page intentionally left blank The Bitterest Pills The Troubling Story of Antipsychotic Drugs Joanna Moncrieff University College London, UK © Joanna Moncrieff 2013 Softcover reprint of the hardcover 1st edition 2013 978-1-137-27742-8 All rights reserved. No reproduction, copy or transmission of this publication may be made without written permission. No portion of this publication may be reproduced, copied or transmitted save with written permission or in accordance with the provisions of the Copyright, Designs and Patents Act 1988, or under the terms of any licence permitting limited copying issued by the Copyright Licensing Agency, Saffron House, 6–10 Kirby Street, London EC1N 8TS. Any person who does any unauthorized act in relation to this publication may be liable to criminal prosecution and civil claims for damages. The author has asserted her right to be identified as the author of this work in accordance with the Copyright, Designs and Patents Act 1988. First published 2013 by PALGRAVE MACMILLAN Palgrave Macmillan in the UK is an imprint of Macmillan Publishers Limited, registered in England, company number 785998, of Houndmills, Basingstoke, Hampshire RG21 6XS. Palgrave Macmillan in the US is a division of St Martin’s Press LLC, 175 Fifth Avenue, New York, NY 10010. Palgrave Macmillan is the global academic imprint of the above companies and has companies and representatives throughout the world. Palgrave® and Macmillan® are registered trademarks in the United States, the United Kingdom, Europe and other countries. ISBN 978-1-137-27743-5 ISBN 978-1-137-27744-2 (eBook) DOI 10.1057/9781137277442 This book is printed on paper suitable for recycling and made from fully managed and sustained forest sources. Logging, pulping and manufacturing processes are expected to conform to the environmental regulations of the country of origin. A catalogue record for this book is available from the British Library. A catalogue record for this book is available from the Library of Congress. Typeset by MPS Limited, Chennai, India. To my life-long companions Sarah, Richard and Madeline This page intentionally left blank Contents List of Tables and Figures x List of Abbreviations xi Preface and Acknowledgements xii 1 Cure or Curse: What Are Antipsychotics? 1 2 Chlorpromazine: The First Wonder Drug 20 3 Magic Bullets: The Development of Ideas on Drug Action 39 4 Building a House of Cards: The Dopamine Theory of Schizophrenia and Drug Action 60 5 The Phoenix Rises: From Tardive Dyskinesia to the Introduction of the ‘Atypicals’ 76 6 Looking Where the Light is: Randomised Controlled Trials of Antipsychotics 91 7 The Patient’s Dilemma: Other Evidence on the Effects of Antipsychotics 113 8 Chemical Cosh: Antipsychotics and Chemical Restraint 132 9 Old and New Drug-Induced Problems 152 10 The First Tentacles: The ‘Early Intervention in Psychosis’ Movement 170 11 The Antipsychotic Epidemic: Prescribing in the Twenty-First Century 189 12 All is not as it Seems 208 Notes 221 Appendix 1: Common Antipsychotic Drugs 223 Appendix 2: Accounts of Schizophrenia and Psychosis 226 References 229 Index 269 ix List of Tables and Figures Tables 1.1 Models of drug action 8 1.2 Positive and negative symptoms of schizophrenia 13 6.1 Randomised trials of antipsychotic treatment of an acute psychotic episode 97 6.2 Recent randomised trials of antipsychotic discontinuation 106 7.1 Verbatim descriptions of subjective effects of antipsychotics from www.askapatient.com 119 7.2 Changes in dimensions of psychosis after antipsychotic treatment 125 10.1 Melbourne criteria for the ‘at risk mental state’ 181 10.2 PIER (Portland Identification and Early Referral) programme 185 Figures 1.1 Kissit demonstration, UK, 2005 3 1.2 Trends in prescriptions of antipsychotics issued in the community in England 6 3.1 Reserpine advertisement 47 3.2 Melleril advertisement 48 3.3 Stelazine advertisement 52 3.4 Melleril advertisement 54 6.1 Northwick Park first episode study: patients remaining relapse-free on drug and placebo 104 7.1 Global adjustment of psychotic patients over 15 years of follow-up 128 8.1 Stelazine advertisement 138 8.2 Stelazine advertisement 140 8.3 Clopixol acuphase advertisement 144 9.1 Incidence rate of sudden death in people taking antipsychotic drugs compared with people not taking them 167 x List of Abbreviations ADHD attention deficit hyperactivity disorder APA American Psychiatric Association BPRS Brief Psychiatric Rating Scale CATIE Clinical Antipsychotic Trial of Intervention Effectiveness study CT computerised tomography D1, D2 dopamine 1 and 2 receptors DSM Diagnostic and Statistical Manual of Mental Disorders ECG electrocardiogram ECT electro-convulsive therapy FDA Food and Drug Administration LSD lysergic acid diethylamide MRI magnetic resonance imaging NAMI National Alliance for the Mentally Ill NICE National Institute of Health and Clinical Excellence NIMH National Institute of Mental Health PACE Personal Assessment and Crisis Evaluation clinic PANSS Positive and Negative Syndrome Scale PET positron emission tomography PIER Portland Identification and Early Referral programme PTSD post-traumatic stress disorder SSRI selective serotonin reuptake inhibitor TIPS Early Identification and Treatment of Psychosis programme VA Veterans Affairs 5-HT2a 5-hydroxytryptamine receptor 2a xi Preface and Acknowledgements I have been interested in the drugs used to treat psychiatric problems ever since, as a junior psychiatrist in the 1990s, I realised how com- pletely drug treatment dominated psychiatric practice, and how inad- equate were the current theories for explaining the effects these drugs had on people in real life. Since their introduction in the 1950s, what we now call ‘antipsychotics’ have become psychiatry’s most iconic treat- ment, symbolising everything that modern psychiatry wishes to portray of itself. They are a simple, easy to administer, seemingly specific medi- cal treatment that, it is claimed, target the underlying biological basis of the most serious and debilitating family of psychiatric conditions, the ‘psychoses,’ including the most frightening and disabling of all forms of madness, schizophrenia. Discovered by chance, so the story goes, and introduced against resistance from an unwilling and psychoanalytically inclined profession, antipsychotics helped to place psychiatry on a sound medical footing, revealing the true nature of psychiatric disorders as diseases of the brain, and enabling patients to be discharged in droves from the old asylums back into normal life. This book will challenge this common perception of the revolution- ary nature of antipsychotics by setting them in the context of the physi- cal interventions that preceded them, procedures like insulin coma therapy, now mostly discredited, and also by reinstating an understand- ing of these substances as drugs, in other words as potentially toxic chemicals that change the way the body functions. It will explore the characteristic alterations that antipsychotics induce, particularly their ‘psychoactive’ effects, that is the way they modify normal processes of thinking and feeling. Exploring the history of antipsychotics reveals that the clinicians and researchers who first prescribed these drugs were interested in these effects and how they impacted on people with mental disturbances of various sorts. As the drugs became transformed in official circles into disease-specific, targeted treatments, however, this knowledge was lost from view. The ideas represented here form an attempt to reclaim this way of understanding the effects of anti- psychotic drugs and their potential role within mental health services. The book also charts the effects of this metamorphosis of anti- psychotics into restorative treatments. The belittling of the drugs’ seri- ous neurological side effects, the denial