Chagas Disease American Trypanosomiasis

Total Page:16

File Type:pdf, Size:1020Kb

Chagas Disease American Trypanosomiasis Chagas Disease American Trypanosomiasis What is Chagas disease and feces after feeding. This fecal material In long term or severe cases, what causes it? contains the protozoa, which then infection of the heart [myocarditis Chagas (SHA-gus) disease (also enters the bite wound created by the (my-O-car-DIE-tis)] and possible heart called American typanosomiasis [tri- “kissing bug”. failure can occur. PAN-o-so-MY-ah-sis]) is caused by a How does Chagas disease Who should I contact if I protozoan (single celled, microscopic) affect my animal? suspect Chagas disease? parasite called Trypanosoma cruzi In Animals – (tri-PAN-o-so-MA cruise-EYE). The In dogs, the most common signs of Contact your veterinarian protozoan infects humans and infection are fever, sluggishness and In Humans – animals through an insect called a an unkept hair-coat. Signs of heart Contact your physician. “kissing bug” (or “assassin bug”). failure may show up after an extended period of time. Other animals do not How can I protect my animal The disease can be seen in dogs typically show any signs of illness. and humans and initially causes flu- from Chagas disease? like signs (fever, headache), which Can I get Chagas disease? Keep animals indoors and away can progress to heart failure over a Yes. People usually get Chagas from insects at night. Wooded areas long period of time. Cases primarily disease from the “kissing bug” (vector) are most likely to harbor the beetle, occur in Central and South America. that bloodfeeds on humans and especially in the southern United A few cases occur occasionally in the transfers the protozoan through its States. Dogs should not be allowed to southern U.S. fecal matter. Occasionally people have contact with wild animals such get Chagas disease from blood as opossums, raccoons and armadillos What animals get Chagas transfusions or by transfer from to reduce the chance of infection. disease? mothers to their babies during In the U.S. dogs, opossums and pregnancy or when nursing. How can I protect myself armadillos are most likely to carry from Chagas disease? People with Chagas disease will the protozoan that causes Chagas have fever, loss of appetite, fatigue, Avoid contact with the “kissing disease. Many other animals can serve swelling at the “kissing bug” bite site bug”. If traveling to Latin America, as carriers (or reservoirs), including and swollen glands or lymph nodes. particularly Central America, take cats, rabbits, raccoons, and rodents. The bug usually bites around the eye. precautions when camping or Generally, dogs are the only animals sleeping in huts to prevent insect bites. that show signs of disease. Kissing beetles are very susceptible Chagas disease to insecticides which can be used to How can my animal get remove the bugs from dwellings. Chagas disease? is caused by Animals can get Chagas disease by a protozoan parasite For More Information living or sleeping outside in an area and spread by the “kissing bug” CFSPH Technical Fact Sheets. Chagas where the “kissing bug” (vector) lives. (Trypanosomiasis-American) at http:// This bug lives in cracks and holes of www.cfsph.iastate.edu/DiseaseInfo/ old, unkept buildings or homes and CDC website. Chagas’ disease at http://www. wooded areas and can be found in cdc.gov/parasites/chagas/ Latin America and as far north as Virginia in the U.S. The protozoa develops in the intestine of the “kissing bug”. This Left photo: The protozoan, Trypanosoma cruzi (From CDC DPDx Parasite Image Library). bug is a blood feeder and will bite its Right photo: A “kissing bug”. host (animal or human), then excrete © 2013.
Recommended publications
  • Chagas Disease in Europe September 2011
    Listed for Impact Factor Europe’s journal on infectious disease epidemiology, prevention and control Special edition: Chagas disease in Europe September 2011 This special edition of Eurosurveillance reviews diverse aspects of Chagas disease that bear relevance to Europe. It covers the current epidemiological situation in a number of European countries, and takes up topics such as blood donations, the absence of comprehensive surveillance, detection and treatment of congenital cases, and difficulties of including undocumented migrants in the national health systems. Several papers from Spain describe examples of local intervention activities. www.eurosurveillance.org Editorial team Editorial board Based at the European Centre for Austria: Reinhild Strauss, Vienna Disease Prevention and Control (ECDC), Belgium: Koen De Schrijver, Antwerp 171 83 Stockholm, Sweden Belgium: Sophie Quoilin, Brussels Telephone number Bulgaria: Mira Kojouharova, Sofia +46 (0)8 58 60 11 38 or +46 (0)8 58 60 11 36 Croatia: Borislav Aleraj, Zagreb Fax number Cyprus: Chrystalla Hadjianastassiou, Nicosia +46 (0)8 58 60 12 94 Czech Republic: Bohumir Križ, Prague Denmark: Peter Henrik Andersen, Copenhagen E-mail England and Wales: Neil Hough, London [email protected] Estonia: Kuulo Kutsar, Tallinn Editor-in-Chief Finland: Hanna Nohynek, Helsinki Ines Steffens France: Judith Benrekassa, Paris Germany: Jamela Seedat, Berlin Scientific Editors Greece: Rengina Vorou, Athens Kathrin Hagmaier Hungary: Ágnes Csohán, Budapest Williamina Wilson Iceland: Haraldur
    [Show full text]
  • Related Protozoan Pathogens, Different Diseases
    Kinetoplastids: related protozoan pathogens, different diseases Ken Stuart, … , Steve Reed, Rick Tarleton J Clin Invest. 2008;118(4):1301-1310. https://doi.org/10.1172/JCI33945. Review Series Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their genetic relatedness and underlined differences in the diseases that they cause. As we discuss in this Review, steady progress using a combination of molecular, genetic, immunologic, and clinical approaches has substantially increased understanding of these pathogens and important aspects of the diseases that they cause. Consequently, the paths for developing additional measures to control these “neglected diseases” are becoming increasingly clear, and we believe that the opportunities for developing the drugs, diagnostics, vaccines, and other tools necessary to expand the armamentarium to combat these diseases have never been better. Find the latest version: https://jci.me/33945/pdf Review series Kinetoplastids: related protozoan pathogens, different diseases Ken Stuart,1 Reto Brun,2 Simon Croft,3 Alan Fairlamb,4 Ricardo E. Gürtler,5 Jim McKerrow,6 Steve Reed,7 and Rick Tarleton8 1Seattle Biomedical Research Institute and University of Washington, Seattle, Washington, USA. 2Swiss Tropical Institute, Basel, Switzerland. 3Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom. 4School of Life Sciences, University of Dundee, Dundee, United Kingdom. 5Departamento de Ecología, Genética y Evolución, Universidad de Buenos Aires, Buenos Aires, Argentina. 6Sandler Center for Basic Research in Parasitic Diseases, UCSF, San Francisco, California, USA.
    [Show full text]
  • 2018 Guideline Document on Chagas Disease
    GUIDELINES AND STANDARDS Recommendations for Multimodality Cardiac Imaging in Patients with Chagas Disease: A Report from the American Society of Echocardiography in Collaboration With the InterAmerican Association of Echocardiography (ECOSIAC) and the Cardiovascular Imaging Department of the Brazilian Society of Cardiology (DIC-SBC) Harry Acquatella, MD, FASE (Chair), Federico M. Asch, MD, FASE (Co-Chair), Marcia M. Barbosa, MD, PhD, FASE, Marcio Barros, MD, PhD, Caryn Bern, MD, MPH, Joao L. Cavalcante, MD, FASE, Luis Eduardo Echeverria Correa, MD, Joao Lima, MD, Rachel Marcus, MD, Jose Antonio Marin-Neto, MD, PhD, Ricardo Migliore, MD, PhD, Jose Milei, MD, PhD, Carlos A. Morillo, MD, Maria Carmo Pereira Nunes, MD, PhD, Marcelo Luiz Campos Vieira, MD, PhD, and Rodolfo Viotti, MD*, Caracas, Venezuela; Washington, District of Columbia; Belo Horizonte and Sao~ Paulo, Brazil; San Francisco, California; Pittsburgh, Pennsylvania; Floridablanca, Colombia; Baltimore, Maryland; San Martin and Buenos Aires, Argentina; and Hamilton, Ontario, Canada In addition to the collaborating societies listed in the title, this document is endorsed by the following American Society of Echocardiography International Alliance Partners: the Argentinian Federation of Cardiology, the Argentinian Society of Cardiology, the British Society of Echocardiography, the Chinese Society of Echocardiography, the Echocardiography Section of the Cuban Society of Cardiology, the Echocardiography Section of the Venezuelan Society of Cardiology, the Indian Academy of Echocardiography,
    [Show full text]
  • Chagas Disease Fact Sheet
    Chagas Disease Fact Sheet What is Chagas disease? What are the symptoms? ■ A disease that can cause serious heart and stomach ■ A few weeks or months after people first get bitten, illnesses they may have mild symptoms like: ■ A disease spread by contact with an infected • Fever and body aches triatomine bug also called “kissing bug,” “benchuca,” • Swelling of the eyelid “vinchuca,” “chinche,” or “barbeiro” • Swelling at the bite mark ■ After this first part of the illness, most people have no Who can get Chagas disease? symptoms and many don’t ever get sick Anyone. However, people have a greater chance if they: ■ But some people (less than half) do get sick later, and they may have: ■ Have lived in rural areas of Mexico, Central America or South America, in countries such as: Argentina, • Irregular heart beats that can cause sudden death Belize, Bolivia, Brazil, Chile, Colombia, Costa Rica, • An enlarged heart that doesn’t pump blood well El Salvador, Ecuador, French Guiana, Guatemala, • Problems with digestion and bowel movements Guyana, Honduras, Mexico, Nicaragua, Panama, • An increased chance of having a stroke Paraguay, Peru, Suriname, Uruguay or Venezuela What should I do if I think I might have ■ Have seen the bug, especially in these areas Chagas disease? ■ Have stayed in a house with a thatched roof or with ■ See a healthcare provider, who will examine you walls that have cracks or crevices ■ Your provider may take a sample of your blood for testing How does someone get Chagas disease? ■ Usually from contact with a kissing bug Why should I get tested for Chagas disease? ■ After the kissing bug bites, it poops.
    [Show full text]
  • Download the Abstract Book
    1 Exploring the male-induced female reproduction of Schistosoma mansoni in a novel medium Jipeng Wang1, Rui Chen1, James Collins1 1) UT Southwestern Medical Center. Schistosomiasis is a neglected tropical disease caused by schistosome parasites that infect over 200 million people. The prodigious egg output of these parasites is the sole driver of pathology due to infection. Female schistosomes rely on continuous pairing with male worms to fuel the maturation of their reproductive organs, yet our understanding of their sexual reproduction is limited because egg production is not sustained for more than a few days in vitro. Here, we explore the process of male-stimulated female maturation in our newly developed ABC169 medium and demonstrate that physical contact with a male worm, and not insemination, is sufficient to induce female development and the production of viable parthenogenetic haploid embryos. By performing an RNAi screen for genes whose expression was enriched in the female reproductive organs, we identify a single nuclear hormone receptor that is required for differentiation and maturation of germ line stem cells in female gonad. Furthermore, we screen genes in non-reproductive tissues that maybe involved in mediating cell signaling during the male-female interplay and identify a transcription factor gli1 whose knockdown prevents male worms from inducing the female sexual maturation while having no effect on male:female pairing. Using RNA-seq, we characterize the gene expression changes of male worms after gli1 knockdown as well as the female transcriptomic changes after pairing with gli1-knockdown males. We are currently exploring the downstream genes of this transcription factor that may mediate the male stimulus associated with pairing.
    [Show full text]
  • Trypanosoma Cruzi Genome 15 Years Later: What Has Been Accomplished?
    Tropical Medicine and Infectious Disease Review Trypanosoma cruzi Genome 15 Years Later: What Has Been Accomplished? Jose Luis Ramirez Instituto de Estudios Avanzados, Caracas, Venezuela and Universidad Central de Venezuela, Caracas 1080, Venezuela; [email protected] Received: 27 June 2020; Accepted: 4 August 2020; Published: 6 August 2020 Abstract: On 15 July 2020 was the 15th anniversary of the Science Magazine issue that reported three trypanosomatid genomes, namely Leishmania major, Trypanosoma brucei, and Trypanosoma cruzi. That publication was a milestone for the research community working with trypanosomatids, even more so, when considering that the first draft of the human genome was published only four years earlier after 15 years of research. Although nowadays, genome sequencing has become commonplace, the work done by researchers before that publication represented a huge challenge and a good example of international cooperation. Research in neglected diseases often faces obstacles, not only because of the unique characteristics of each biological model but also due to the lower funds the research projects receive. In the case of Trypanosoma cruzi the etiologic agent of Chagas disease, the first genome draft published in 2005 was not complete, and even after the implementation of more advanced sequencing strategies, to this date no final chromosomal map is available. However, the first genome draft enabled researchers to pick genes a la carte, produce proteins in vitro for immunological studies, and predict drug targets for the treatment of the disease or to be used in PCR diagnostic protocols. Besides, the analysis of the T. cruzi genome is revealing unique features about its organization and dynamics.
    [Show full text]
  • Zoonotic Disease Scenarios
    Zoonotic Disease Scenarios: Malaria, Arboviruses, Chagas Disease, Lyme Disease, and Rickettsial Diseases ELC Meeting – September 2019 Zoonosis Control Branch Malaria Case Scenario A new ELR appears in the DRR queue for a blood smear, with a positive result for malaria. Resiu l~edl Test: MICROSCOPIC OBSERVATION:PRIO:PT:BLO:NOMl :MAL.ARIA SMIEAR(Mala 11ia S nnear) Result(st: Posimive(S I OMED) Refelrence Range: 1 eg1ative Datem ime: 2019-IJ2-0'9 12:09:IJO .O , ·erpreta~iio 111 : Nlormal Perilforming Faciility: University Med C r Result Method: IFaciility ID: 5D06607 4'1 (Fl) Status: f inal "[;est Code(s): 32700-7 (LIN LOINC) 1278 (L l OCAL) !Result Code(s): '1O B281J04 (SNM SNOMED) I R.es u It Comm e111ts: 09/26/2019 DSHS ELC Conference 2 Malaria Case Scenario (continued) The species has not been determined yet. Upon reviewing the medical record, you learn that the patient is a 62-year-old female who is a resident of Nigeria and returning home next month. Q: Is this a reportable Texas malaria case? YES! 09/26/2019 DSHS ELC Conference 3 Malaria Reporting Guidelines Texas Residents For malaria cases who reside in Texas, but are diagnosed in another Texas jurisdiction, please report by the case patient’s residence. Out of Country Residents For malaria cases who reside in another country, but are diagnosed in Texas, please report by the location where the patient was diagnosed. Out of State Residents For malaria cases who reside in another state, but are diagnosed in Texas, please communicate with the Regional Zoonosis Control (ZC) office so we can work with the other state to determine which state will count it as a case to prevent dual reporting.
    [Show full text]
  • Parasitic Infections Seen in Impoverished Areas
    44 INFECTIOUS DISEASES NOVEMBER 15, 2010 • FAMILY PRACTICE NEWS Parasitic Infections Seen in Impoverished Areas The prevalence of Trichomonas vaginalis in the grate and encyst in humans but do not treatment. Visceral disease is treated develop into adults or reproduce in with 5 days of albendazole; cortico- United States is estimated at 20 million people. humans. steroids may be used for allergic symp- According to data from the National toms. Ocular toxocariasis is treated with BY KERRI WACHTER acute infection, a blood smear, hemo- Health and Nutrition Examination Sur- 2-4 weeks of albendazole, along with ag- culture, and polymerase chain reaction vey (NHANES), approximately 14% of gressive anti-inflammatory treatment FROM A TELECONFERENCE SPONSORED BY THE CENTERS FOR DISEASE CONTROL (PCR) tests are useful. For chronic in- the U.S. population is infected. The high- with corticosteroids, and surgery. Al- AND PREVENTION fection, serologic tests are useful. How- est prevalence is in the southern United bendazole is not approved by the FDA ever, there is no preferred test. States (less than 17%). Toxocariasis af- for this indication. ertain infectious diseases can con- Tests for acute infection are sensitive, fects non-Hispanic blacks more than oth- centrate in impoverished areas but the acute phase often is not recog- er groups and is associated with pover- Trichomoniasis Cand disproportionately affect mi- nized. Tests for chronic infection have is- ty, low education level, and dog Trichomonas vaginalis is a parasite that is norities, women, and other disadvan- sues with sensitivity and specificity, and ownership. spread through sexual contact. It’s esti- taged groups, according to Dr.
    [Show full text]
  • Parasitology – First Quadrimester, 2021
    AAB PARASITOLOGY – FIRST QUADRIMESTER, 2021 American Association of Bioanalysts Proficiency Testing 11931 Wickchester Ln., Ste. 200 Houston, TX 77043 800-234-5315 ♦ 281-436-5357 Q1 2021 Parasitology Sample 1 Referees Extent 1 Extent 2 Total Code - Organism Frequency % No. % No. % No. % No. 525 – No parasites found None 50% 5 11.1% 1 44.4% 8 33.3% 9 544 – Endolimax nana 44.4% 4 11.1% 2 22.2% 6 533 – Dientamoeba fragilis Few 40.0% 4 0.0% 0 27.8% 5 18.5% 5 546 – Entamoeba hartmanii Few 10.0% 1 11.1% 1 11.1% 2 11.1% 3 524 – parasite(s) found referred for ID 33.3% 3 0.0% 0 11.1% 3 553 – Cryptosporidium sp. 0.0% 0 5.6% 1 3.7% 1 Due to a lack of consensus, Sample 1 was not evaluated this event. The intended organism was 533-Dientamoeba fragilis. SPECIMEN 1: FORMALIN: Specimen 1A was a fecal suspension in 10% formalin for direct wet mount examination; concentration was not necessary. The specimen was to be examined for all parasites unstained, with iodine or other acceptable wet mount stain. The specimen contains Dientamoeba fragilis trophozoites. Typically, it is very difficult if not impossible to identify these organisms from a wet mount examination. SPECIMEN 1: PERMANENT SMEAR FOR STAINING: Specimen 1B was the smear to be stained and examined. This specimen contains Dientamoeba fragilis. Due to a lack of participant consensus, Specimen 1 was not evaluated for this event. However, 40% of the Referees correctly reported Dientamoeba fragilis. Many Referees (50%) and Participants (33.3%) reported the specimen as negative.
    [Show full text]
  • Non-Leishmania Parasite in Fatal Visceral Leishmaniasis–Like Disease, Brazil
    DISPATCHES Non-Leishmania Parasite in Fatal Visceral Leishmaniasis–Like Disease, Brazil Sandra R. Maruyama,1 Alynne K.M. de Santana,1,2 performed whole-genome sequencing of 2 clinical isolates Nayore T. Takamiya, Talita Y. Takahashi, from a patient with a fatal illness with clinical characteris- Luana A. Rogerio, Caio A.B. Oliveira, tics similar to those of VL. Cristiane M. Milanezi, Viviane A. Trombela, Angela K. Cruz, Amélia R. Jesus, The Study Aline S. Barreto, Angela M. da Silva, During 2011–2012, we characterized 2 parasite strains, LVH60 Roque P. Almeida,3 José M. Ribeiro,3 João S. Silva3 and LVH60a, isolated from an HIV-negative man when he was 64 years old and 65 years old (Table; Appendix, https:// Through whole-genome sequencing analysis, we identified wwwnc.cdc.gov/EID/article/25/11/18-1548-App1.pdf). non-Leishmania parasites isolated from a man with a fatal Treatment-refractory VL-like disease developed in the man; visceral leishmaniasis–like illness in Brazil. The parasites signs and symptoms consisted of weight loss, fever, anemia, infected mice and reproduced the patient’s clinical mani- festations. Molecular epidemiologic studies are needed to low leukocyte and platelet counts, and severe liver and spleen ascertain whether a new infectious disease is emerging that enlargements. VL was confirmed by light microscopic exami- can be confused with leishmaniasis. nation of amastigotes in bone marrow aspirates and promas- tigotes in culture upon parasite isolation and by positive rK39 serologic test results. Three courses of liposomal amphotericin eishmaniases are caused by ≈20 Leishmania species B resulted in no response.
    [Show full text]
  • Maintenance of Trypanosoma Cruzi, T. Evansi and Leishmania Spp
    IJP: Parasites and Wildlife 7 (2018) 398–404 Contents lists available at ScienceDirect IJP: Parasites and Wildlife journal homepage: www.elsevier.com/locate/ijppaw Maintenance of Trypanosoma cruzi, T. evansi and Leishmania spp. by domestic dogs and wild mammals in a rural settlement in Brazil-Bolivian border T ∗ Grasiela Edith de Oliveira Porfirioa, Filipe Martins Santosa, , Gabriel Carvalho de Macedoa, Wanessa Teixeira Gomes Barretob, João Bosco Vilela Camposa, Alyssa C. Meyersc, Marcos Rogério Andréd, Lívia Perlesd, Carina Elisei de Oliveiraa, Samanta Cristina das Chagas Xaviere, Gisele Braziliano de Andradea, Ana Maria Jansene, Heitor Miraglia Herreraa,b a Programa de Pós-Graduação em Ciências Ambientais e Sustentabilidade Agropecuária, Universidade Católica Dom Bosco, Tamandaré Avenue, 6000. Jardim Seminário, Cep 79117-900, Campo Grande, Mato Grosso do Sul, Brazil b Programa de Pós-Graduação em Ecologia e Conservação, Universidade Federal de Mato Grosso do Sul, Costa e Silva Avenue, Cep 79070-900, Campo Grande, Mato Grosso do Sul, Brazil c Department of Veterinary Integrative Biosciences, Texas A&M University, 402 Raymond Stotzer Parkway, 4458, College Station, Texas, USA d Universidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Prof. Paulo Donato Castelane Street, Cep 14884-900, Jaboticabal, São Paulo, Brazil e Laboratório de Biologia de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Brazil Avenue, 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro, Brazil ARTICLE INFO ABSTRACT Keywords: Domestic dogs are considered reservoirs hosts for several vector-borne parasites. This study aimed to evaluate Canine the role of domestic dogs as hosts for Trypanosoma cruzi, Trypanosoma evansi and Leishmania spp. in single and Neglected diseases co-infections in the Urucum settlement, near the Brazil-Bolivian border.
    [Show full text]
  • Plants As Sources of Anti-Protozoal Compounds
    PLANTS AS SOURCES OF ANTI- PROTOZOAL COMPOUNDS Thesis presented by Angela Paine for the degree of Doctor of Philosophy in the Faculty of Medicine of the University of London Department of Pharmacognosy The School of Pharmacy University of London 1995 ProQuest Number: 10104878 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. uest. ProQuest 10104878 Published by ProQuest LLC(2016). Copyright of the Dissertation is held by the Author. All rights reserved. This work is protected against unauthorized copying under Title 17, United States Code. Microform Edition © ProQuest LLC. ProQuest LLC 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106-1346 dedicated to my late father Abstract The majority of the world's population relies on traditional medicine, mainly plant-based, for the treatment of disease. This study focuses on plant remedies used to treat tropical diseases caused by protozoan parasites. The following protozoal diseases: African trypanosomiasis, leishmaniasis. South American trypanosomiasis and malaria, and the traditional use of plant remedies in their treatment, are reviewed in a world wide context. In the present work, vector and mammalian forms of Trypanosoma b. brucei, the vector forms of Leishmania donovani and Trypanosoma cruzi and the mammalian forms of Plasmodium falciparum were maintained in culture in vitro in order to evaluate the activity of a series of plant extracts, pure natural products and synthetic analogues against these protozoan parasites in vitro.
    [Show full text]