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Useful Anti-Cancerous & Anti-Tumorous Asian Medicinal Plants

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Useful Anti-Cancerous & Anti-Tumorous Asian Medicinal Plants Pawan Kumar Sagar et al., IJTCM, 2020, 5:22 Review Article IJTCM (2020), 5:22 International Journal of Traditional and Complementary Medicine ( (ISSN:2474-1361) Useful Anti-Cancerous & Anti-tumorous Asian medicinal Plants (Taxus baccata L. or Taxus baccata Thunb., Catharanthus roseus(L.) G. Don, Annona muricata L.) Pawan Kumar Sagar*1, R P Meena4, Mohd Washim Ahmad3, Kunal Sajwan4 *1.2,3. Drug StandardizationResearch Institute, (CCRUM., Ministry of AYUSH.), PLIM., Campus, Kamlanehru nagar, Ghaziabad, U.P. ,India; 4. Central Council for Research of Unani Medicine, Ministry of AYUSH., Janakpuri, D-Block, New Delhi, India ABSTRACT Cancer is one of the harmful leading causes of death worldwide. *Correspondence to Author: Several synthetic agents have been used to cure the disease Pawan Kumar Sagar but they have their adverse side effects, low-hilling potential and Drug StandardizationResearch toxicity.Present Article reviewed three important medicinal plants Institute, (CCRUM., Ministry i.e.- Taxus baccata L. Or Taxus baccata Thunb., Catharanthus of AYUSH.), PLIM., Campus, roseus(L.) G.Don and Annona muricata L. which traditionally Kamlanehru nagar, Ghaziabad, U.P. used since ancient time for the treatment and prevention of ,India Cancer and Tumor in Sothern, Northern-east and Himalayan region of India. Having active phytochemical constitutents How to cite this article: Taxanes- Alkaloids(Taxol and Taxotere), Larotaxel,nab-Paclitaxel Pawan Kumar Sagar, R P Meena, present in T. baccata L. Or T.baccata Thunb. and Vinca-Alkaloid Mohd Washim Ahmad, Kunal as Vinblastine, Vincristine, Vinorelbine, Vinflunine, catharanthine Sajwan. Useful Anti-Cancerous and vindoline alkaloids in Catharanthus roseus(L.) G.Don, & Anti-tumorous Asian medicinal as well as Muricin J, Muricin K, Muricin L, Cinnamic acid Plants (Taxus baccata L. or Taxus derivative, Coumaric acid hexose, Annomuricin A, Annomuricin baccata Thunb., Catharanthus B, Annomuricin C, Annomuricin E, Annomutacin, Annhexocin, roseus(L.) G. Don, Annona Muricatocin A, Muricatocin B, Muricatocin C, Giganletronenin, muricata L.).International Journal Annonacin A, Annopentocin A, Annopentocin B, Annopentocin of Traditional and Complementary C etc. present in A muricata L. This report also revealed the Medicine 2020, 5:22. ethno-botanicaly and biological activities of active principles of these plants that will help in noval drug discovery, noval new active phytochemical constituents of anti-cancer and anti-tumor formulations and development of pharmacopial standareds. Keywords: Anti-cancerous, Anti-tumorous, medicinal plants, eSciPub LLC, Houston, TX USA. bio-actives constituents, bio available, ethno-botany. Website: https://escipub.com/ IJTCM: https://escipub.com/international-journal-of-traditional-and-complementary-medicine/ 1 For Proof Only Pawan Kumar Sagar et al., IJTCM, 2020, 5:22 Introduction: agents, the research is going on to investigate the plant derived chemotherapeutic agents Cancer is one of the deadly diseases which are without toxicity. Bio-prospective for plants characterized by irregular cell proliferation. The important with anti-cancer activity has been a most common cause behind the cancer is major focus in the search for plant. (Bhist et al., lifestyle changes. According to World Health 2011 ;Raskin et al., 2002)Anti-neoplasm activity Organization, more than 14 million people is defined as effect of natural, synthetic or diagnosed with cancer and 9 million died in biological chemical agents used to reverse, 2013. (www.who.int) (Ray et al., 2017 and suppress or prevent carcinogenic progression WHO.2017)High mortality rate makes it an (Madhuri and Pandey, 2009). Chemically important public health and economic issue synthesized agents have their toxicity and DNA which requires an effective prevention.Medicinal damage induction potential which limits their plants have various advantages over chemical uses. (Bist et al., 2011 ;Sasaki et al.,2002) products, because plants derived compounds Himalayan plants grown in high altitude are the are more tolerable and les-toxic to the normal rich source of various secondary metabolites human cells. Already available conventional such as anthraquinones, flavonoids, tannins, therapies for the treatment of cancer are alkaloids and a wide range of secondary radiotherapy and chemotherapy which have metabolites which include flavonoids, flavones, various toxicity, serious side effects and thus anthocyanins, lignans, coumarins, isocatechins affecting the health of the persons. Therefore, an and catechins etc.(Roy et al., 2017; Singh et al., alternative method is required that include less 2013; Sumer J.2000). National Cancer Institute toxic and more potent anticancer drug as has approximately screened 35,000 plant compare to the drugs available in the market. species for their potential anticancer activities Recently there has been an increased scientific and they have found that among them about interest in the study of material from plant source 3,000 plant species have shown reproducible as an anticancer compound. Several studies anticancer activity. (Sumner J. 2000)India has a have found the role of medicinal plants in rich history of using plants for health care in prevention and treatment of cancer. (Greenwell general (Misra et al.,2008)and treatment of et al., 2015) Since Epithelial cells cover the skin, cancer in particular with out causing toxicity lining of the respiratory and alimentary tracts, (Madhuri and Pandey, 2009).Cancer has and metabolize ingested carcinogens, it is not become an important Public Health Problem surprising that over 90% of cancer occur in with over 900,000 new cases occurring every epithelial tissues(Kainsa et al., 2012). Plants are year and is one of the ten leading causes of an important source of synthetic and herbal death in India(Misra et al., 2008; Devi, 2009). agents used in several pharmaceutical The beneficial medicinal effects of plant industries. Some of the prominent plant derived materials typically result from the combination of compound have a major role in the development these secondary products (Dai et al., 2010; of several clinically useful anticancer agents Tonthubthim thong et al., 2001).In 1985 such as Vinblastine, Vincristine, teniposide and Farnsworth et al. identified 119 secondary plant etoposide derivative, topotecan, paclitaxel metabolites which were used as drugs. Out of (Taxol) etc. (Singh et al., 2013). Taxol and 255 drugs which are considered as basic and Camptothecin were among the most important essential by the World Health anti-cancer compound derived from plants Organization(WHO), 11% are obtained from available today. (Bist et al., 2011 ;Suhas et al., plants and a number of synthetic drugs are also 2007)Because the genuine region of the serious obtained from natural precursors. Herbal plants side effects of synthetic chemo-preventive based extract medicines worldwide use in Asia, IJTCM: https://escipub.com/international-journal-of-traditional-and-complementary-medicine/ 2 Pawan Kumar Sagar et al., IJTCM, 2020, 5:22 Europe, China, Japan, Korea, Malaysia, Ghaziabad, U.P., India - SMPU. &DSRU. Units Canadia for cure of human being since ancient under Ministry of AYUSH., Govt. of India, time and has provides to them a miraculous INMAS, (DRDO.), under ministry of AYUSH., powerful sprite or fight again several harmful Govt. of India, Scientiest and researchers. disease with contain highly safe and efficacious 1. Talispatr, Telis Patta / Zarnab / Taxus higher yielding, standard quality formulated (Taxus baccata L. orTaxus products without any adverse and side effect. baccataThunb.): Methods:The sources of scientific literature Taxus baccata is a conifer native to western, were accessed from various electronic central and southern Europe, northwest Africa, databases such as PubMed, Google Scholar, northern Iran and southwest Asia. It is found in Science Direct, and library search, studies drugs India northern Himalaya region, it is commonly samples authonicated and confiremed of these known as Himalayan yew. It is used in the botanical, scientific indentification by our Experts treatment of many diseases including cystitis, botanist, pharmacognosistScientist and eruptions, headaches, heart and kidney Researchers of Council research Institutes problems, rheumatism etc. All parts of the plant, CRIUM, Hyderabad, T.S., India & RRIUM, except the flesh of the fruit, are highly poisonous, Chennai, T.N., India as well as DSRI, having a paralyzing affect on the heart. Fig.1:Taxus baccata: a.Branches b. Leaves and seed c. Leaves with seeds cones LanguageCommon name Persian : Zarnab Urdu : Zarnab Punjabi : Birmi Cashmerian : Taxus Sanskrit : Mandhuparni, Talispatra, Sukapuspa Arabic: Talisfar Habitat:Woods and scrub, usually on limestone. Bengali : Birmi, Talish Patra, Bhada Getela It sometimes forms pure stands in sheltered sites on chalk in the south-east and on limestone Chinese : Tzu shan in the north-west. Seed can be very slow to English: Yew, Common Yew, Chinwood germinate, often taking 2 or more years. It is best French: Ifcommun sown as soon as it is ripe in the autumn when it German: Eibe, Eife, Ibenbaum, Kantelbaum, should germinate 18 months later. Stored seed Taxbaum, Ybe may take 2 years or more to germinate. 4 Gujarati: Gethela Barmi months warm followed by 4 months cold stratification may help reduce the germination Hindi: Talispatr, Talis Patta time. Kannada: Sthauneyak Description: it is a small to medium-sized Marathi: Sthauney Barmi evergreen tree, growing
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