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Pawan Kumar Sagar et al., IJTCM, 2020, 5:22

Review Article IJTCM (2020), 5:22

International Journal of Traditional and Complementary Medicine ( (ISSN:2474-1361)

Useful Anti-Cancerous & Anti-tumorous Asian medicinal (Taxus baccata L. or Taxus baccata Thunb., roseus(L.) G. Don, Annona muricata L.) Pawan Kumar Sagar*1, R P Meena4, Mohd Washim Ahmad3, Kunal Sajwan4

*1.2,3. StandardizationResearch Institute, (CCRUM., Ministry of AYUSH.), PLIM., Campus, Kamlanehru nagar, Ghaziabad, U.P. ,; 4. Central Council for Research of Unani Medicine, Ministry of AYUSH., Janakpuri, D-Block, , India

ABSTRACT Cancer is one of the harmful leading causes of death worldwide. *Correspondence to Author: Several synthetic agents have been used to cure the disease Pawan Kumar Sagar but they have their adverse side effects, low-hilling potential and Drug StandardizationResearch .Present Article reviewed three important Institute, (CCRUM., Ministry i.e.- Taxus baccata L. Or Taxus baccata Thunb., Catharanthus of AYUSH.), PLIM., Campus, roseus(L.) G.Don and Annona muricata L. which traditionally Kamlanehru nagar, Ghaziabad, U.P. used since ancient time for the treatment and prevention of ,India Cancer and Tumor in Sothern, Northern-east and Himalayan region of India. Having active phytochemical constitutents How to cite this article: Taxanes- (Taxol and Taxotere), Larotaxel,nab-Paclitaxel Pawan Kumar Sagar, R P Meena, present in T. baccata L. Or T.baccata Thunb. and - Mohd Washim Ahmad, Kunal as , , , Vinflunine, catharanthine Sajwan. Useful Anti-Cancerous and vindoline alkaloids in Catharanthus roseus(L.) G.Don, & Anti-tumorous Asian medicinal as well as Muricin J, Muricin K, Muricin L, Cinnamic acid Plants (Taxus baccata L. or Taxus derivative, Coumaric acid hexose, Annomuricin A, Annomuricin baccata Thunb., Catharanthus B, Annomuricin C, Annomuricin E, Annomutacin, Annhexocin, roseus(L.) G. Don, Annona Muricatocin A, Muricatocin B, Muricatocin C, Giganletronenin, muricata L.).International Journal Annonacin A, Annopentocin A, Annopentocin B, Annopentocin of Traditional and Complementary C etc. present in A muricata L. This report also revealed the Medicine 2020, 5:22. ethno-botanicaly and biological activities of active principles of these plants that will help in noval drug discovery, noval new active phytochemical constituents of anti-cancer and anti-tumor formulations and development of pharmacopial standareds. Keywords: Anti-cancerous, Anti-tumorous, medicinal plants, eSciPub LLC, Houston, TX USA. bio-actives constituents, bio available, ethno-botany. Website: https://escipub.com/

IJTCM: https://escipub.com/international-journal-of-traditional-and-complementary-medicine/ 1 For Proof Only Pawan Kumar Sagar et al., IJTCM, 2020, 5:22 Introduction: agents, the research is going on to investigate the derived chemotherapeutic agents Cancer is one of the deadly diseases which are without toxicity. Bio-prospective for plants characterized by irregular cell proliferation. The important with anti-cancer activity has been a most common cause behind the cancer is major focus in the search for plant. (Bhist et al., lifestyle changes. According to World Health 2011 ;Raskin et al., 2002)Anti-neoplasm activity Organization, more than 14 million people is defined as effect of natural, synthetic or diagnosed with cancer and 9 million died in biological chemical agents used to reverse, 2013. (www.who.int) (Ray et al., 2017 and suppress or prevent carcinogenic progression WHO.2017)High mortality rate makes it an (Madhuri and Pandey, 2009). Chemically important public health and economic issue synthesized agents have their toxicity and DNA which requires an effective prevention.Medicinal damage induction potential which limits their plants have various advantages over chemical uses. (Bist et al., 2011 ;Sasaki et al.,2002) products, because plants derived compounds Himalayan plants grown in high altitude are the are more tolerable and les-toxic to the normal rich source of various secondary metabolites human cells. Already available conventional such as anthraquinones, flavonoids, tannins, therapies for the treatment of cancer are alkaloids and a wide range of secondary radiotherapy and which have metabolites which include flavonoids, flavones, various toxicity, serious side effects and thus anthocyanins, lignans, coumarins, isocatechins affecting the health of the persons. Therefore, an and catechins etc.(Roy et al., 2017; Singh et al., alternative method is required that include less 2013; Sumer J.2000). National Cancer Institute toxic and more potent anticancer drug as has approximately screened 35,000 plant compare to the available in the market. species for their potential anticancer activities Recently there has been an increased scientific and they have found that among them about interest in the study of material from plant source 3,000 plant species have shown reproducible as an anticancer compound. Several studies anticancer activity. (Sumner J. 2000)India has a have found the role of medicinal plants in rich history of using plants for health care in prevention and treatment of cancer. (Greenwell general (Misra et al.,2008)and treatment of et al., 2015) Since Epithelial cells cover the skin, cancer in particular with out causing toxicity lining of the respiratory and alimentary tracts, (Madhuri and Pandey, 2009).Cancer has and metabolize ingested carcinogens, it is not become an important Public Health Problem surprising that over 90% of cancer occur in with over 900,000 new cases occurring every epithelial tissues(Kainsa et al., 2012). Plants are year and is one of the ten leading causes of an important source of synthetic and herbal death in India(Misra et al., 2008; Devi, 2009). agents used in several pharmaceutical The beneficial medicinal effects of plant industries. Some of the prominent plant derived materials typically result from the combination of compound have a major role in the development these secondary products (Dai et al., 2010; of several clinically useful anticancer agents Tonthubthim thong et al., 2001).In 1985 such as Vinblastine, Vincristine, teniposide and Farnsworth et al. identified 119 secondary plant etoposide derivative, topotecan, paclitaxel metabolites which were used as drugs. Out of (Taxol) etc. (Singh et al., 2013). Taxol and 255 drugs which are considered as basic and Camptothecin were among the most important essential by the World Health anti-cancer compound derived from plants Organization(WHO), 11% are obtained from available today. (Bist et al., 2011 ;Suhas et al., plants and a number of synthetic drugs are also 2007)Because the genuine region of the serious obtained from natural precursors. Herbal plants side effects of synthetic chemo-preventive based extract medicines worldwide use in Asia,

IJTCM: https://escipub.com/international-journal-of-traditional-and-complementary-medicine/ 2 Pawan Kumar Sagar et al., IJTCM, 2020, 5:22 Europe, China, Japan, Korea, , Ghaziabad, U.P., India - SMPU. &DSRU. Units Canadia for cure of human being since ancient under Ministry of AYUSH., Govt. of India, time and has provides to them a miraculous INMAS, (DRDO.), under ministry of AYUSH., powerful sprite or fight again several harmful Govt. of India, Scientiest and researchers. disease with contain highly safe and efficacious 1. Talispatr, Telis Patta / Zarnab / Taxus higher yielding, standard quality formulated (Taxus baccata L. orTaxus products without any adverse and side effect. baccataThunb.): Methods:The sources of scientific literature Taxus baccata is a conifer native to western, were accessed from various electronic central and southern Europe, northwest Africa, databases such as PubMed, Google Scholar, northern Iran and southwest Asia. It is found in Science Direct, and library search, studies drugs India northern Himalaya region, it is commonly samples authonicated and confiremed of these known as Himalayan yew. It is used in the botanical, scientific indentification by our Experts treatment of many diseases including cystitis, botanist, pharmacognosistScientist and eruptions, headaches, heart and kidney Researchers of Council research Institutes problems, rheumatism etc. All parts of the plant, CRIUM, Hyderabad, T.S., India & RRIUM, except the flesh of the , are highly poisonous, Chennai, T.N., India as well as DSRI, having a paralyzing affect on the heart.

Fig.1:Taxus baccata: a.Branches b. and seed c. Leaves with seeds cones LanguageCommon name Persian : Zarnab Urdu : Zarnab Punjabi : Birmi Cashmerian : Taxus Sanskrit : Mandhuparni, Talispatra, Sukapuspa Arabic: Talisfar Habitat:Woods and scrub, usually on limestone. Bengali : Birmi, Talish Patra, Bhada Getela It sometimes forms pure stands in sheltered sites on chalk in the south-east and on limestone Chinese : Tzu shan in the north-west. Seed can be very slow to English: Yew, Common Yew, Chinwood germinate, often taking 2 or more years. It is best French: Ifcommun sown as soon as it is ripe in the autumn when it German: Eibe, Eife, Ibenbaum, Kantelbaum, should germinate 18 months later. Stored seed Taxbaum, Ybe may take 2 years or more to germinate. 4 Gujarati: Gethela Barmi months warm followed by 4 months cold stratification may help reduce the germination Hindi: Talispatr, Talis Patta time. Kannada: Sthauneyak Description: it is a small to medium-sized Marathi: Sthauney Barmi evergreen tree, growing 10-20 meters(33-66-

IJTCM: https://escipub.com/international-journal-of-traditional-and-complementary-medicine/ 3 Pawan Kumar Sagar et al., IJTCM, 2020, 5:22 ft)(exceptionally up to 28 meters(92 ft) tall, with phytochemical constituents marker compounds a trunk up to 2 meters(6 ft 7 in) (exceptionally 4 as well as these showen and confiremed Anti- meters (13 ft)diameter. The bark is thin, scaly Tumor, Anti-Cancer (Bladder and pancreatic, brown, coming off in small flakes aligned with the Ovarian and breast cancer) and Anti- stem. The leaves are flat, dark green, 1-4 Carcinogenic activities In-vitro, In-vivo various centimeters(0.39-1.57) in long and 2-3 milli cells lines, Animal clinical trail studies. (detail meters (0.079-0.118 in) broad, arranged spirally showen in Fig.:-1.a,b,c, and Table-1,2 &3, on the stem, but with the bases twisted to Sr.N0.-1) align the leaves in two flat rows either side of the 2. Sadabahar (Catharanthus roseus(L.) G. stem, except on erect leading shoots where the Don) : spiral arrangement is more obvious. The leaves It is commonly known as the are poisonous The seed cones are modified, periwinkle, rose periwinkle, or rosy periwinkle, is each cone containing a single seed, which is 4- a species of in the dogbane 7 millimetres (0.16-0.28 in) long, and partly family . It is native and endemic to surrounded by a fleshy scale which develops Madagascar, but grown elsewhere as an into a soft, bright red berry-like structure called ornamental and medicinal plant, a source of the an aril. In Taxus baccata reported and present drugs vincristine and vinblastine, used to treat Taxanes- Alkaloids(Taxol and Taxotere), cancer. Larotaxel,nab-Paclitaxeletc. active

Fig.2:- a. Catharanthus roseus branches b. Leaves with c. Leaves with flowers

Language Common name Habitat: In the wild, it is an endangered plant; the English: Cayenne jasmine, old maid, periwinkle main cause of decline is habitat destruction by slash and burn . It is also however Hindi: Sada bahar, sadabahar widely cultivated and is naturalized in subtropical Kannada: Batla hoo, bili kaasi kanigalu, and tropical areas of the world.It is so well ganeshana hoo, kempu adapted to growth in , that it is listed as kaasi kanigalu, kempu kaayi a noxious weed in and the kanagilu, sadaa mallige, Australian Capital Territory, and also in parts of thuruku mallige eastern Queensland and also found in Asia Malayalam: Banappuvu, nityakalyani, savanari, region, in India southern region, northern usamalari domestic and forest region Marathi: Sadaphool, sadaphuli Description: It is an evergreen or Sanskrit: Nityakalyani, sadapushpi growing 1 m tall.The leaves Tamil : Nithyakalyani, sudukattu mallikai are oval to oblong, 2.5-9 cm long and 1-3.5 cm broad, glossy green, hairless, with a pale midrib Telugu: Billaganneru and a short petiole 1-1.8 cm long; they are

IJTCM: https://escipub.com/international-journal-of-traditional-and-complementary-medicine/ 4 Pawan Kumar Sagar et al., IJTCM, 2020, 5:22 arranged in opposite pairs. The flowers are white activities In-vitro, In-vivo various cells lines, to dark pink with a darker red centre, with a basal Animal clinical trail studies. (detail showen in tube 2.5-3 cm long and a corolla 2-5 cm diameter Fig.:-2.a,b,c andTable-1,2 &3, Sr.N0.-2) with five -like lobes.The fruit is a pair of 3. Laxmanphal /Graviola (Annona follicles2-4 cm long and 3 mm broad. muricataL.) : In Catharanthus roseusreported and present Annona muricata, a broad leaf, flowering, Vinca-Alkaloid as Vinblastine, Vincristine, evergreen tree. The exact origin is unknown; it is Vinorelbine, Vinflunine, catharanthine and native to the tropicalregions of the Americas and vindoline alkaloids, Steroids, Saponin, is widely propagated. It is in the same genus, Cynogenic glycosides ,Cardiac glycoside, Annona, as cherimoya and is in the Annonaceae Flavonoids and Phenols etc. active family. The soursop is adapted to areas of high phytochemical constituents marker compounds humidity and relatively warm winters; as well as these showen and confiremed Anti- temperatures below 5 °C(41 °F) will cause Tumors,(Breast, Colon, Cervical, neck and damage to leaves and small branches, and Head,Anti-Cancers (Leukemias, testicular, temperatures below 3 °C (37 °F) can be fatal. Breast, ovary, cervix, lung, rectum and testis The fruit becomes dry and is no longer good for cancer and Colon Cancers)Anti-Carcinogenic concentrate.

Fig.:-3, a. Annona muricata plant branches b. part c. Leaves part

Language Common name Indonesia, the Caribbean islands and South English : Graviola, guanabana, Pacific countries, it is know as soursop and an soursop evergreen plant mostly distributed in tropical and subtropical region of the world including India, Hindi : Laxmanphal Malaysia and Nigeria, Australia, Africa, the Kannada : Mullu raama phala, mullu leaves are used in bath to treat skin ailments, raamana phala, mullu ramaphala while in Mauritius, New Guinea and Ecuador the Malayalam : Mullancakka, application of leaves is local on the pain site.It is mullanchukka, vilattinuna adapted to warm, humid tropical climate, and Marathi : Mamaphal, mamphal can tolerate both drought conditions and partial Tamil : Mulcita, mullu citta, shade.3.This fruit crop grows in any kind of soil mulluccita, mulluccitta, but prefers loose, fairly rich, deep loam and well- mutcita, mutcitamaram, drained soil with pH ranging from 6.1 to 6.5, It pulippala thrives well from sea level up to 300 meters above sea level although it is known to grow up Telugu : Lakshmana phalamu to 1000 m. Habitat:Annona muricata is native to South America, cultivated and naturalized widely.In

IJTCM: https://escipub.com/international-journal-of-traditional-and-complementary-medicine/ 5 Pawan Kumar Sagar et al., IJTCM, 2020, 5:22 Description: Annona muricata is a shrub or small In Annona muricata reported and present tree 3-10 meters in height. It is adapted to warm, Muricin J, Muricin K, Muricin L, Cinnamic acid humid tropical climate, and can tolerate both derivative, Coumaric acid hexose, 5- drought conditions and partial shade.It grows up Caffeoylquinic acid, Annomuricin A, to 25-30 ft. Young branchlets are rusty-hairy. Annomuricin B, Annomuricin C, Annomuricin E, The leaves, normally evergreen, are alternate, Annomutacin, Annhexocin, Muricapentocin, (2- smooth, glossy, dark green on the upper 4-cis)-isoannonacin,(2,4-trans)-isoannonacin, surface, lighter beneath, oblong, elliptic or Muricatocin A, Muricatocin B, Muricatocin C, narrowobovate, pointed at ends, 6-20 cm long Giganletronenin, Annonacin A, Annopentocin A, and 2.5-6 cm wide. The flowers, borne singly, Annopentocin B, Annopentocin C etc. active may emerge anywhere on the trunk, branches or phytochemical constituents marker compounds twigs. The fruit is more or less oval or heart- as well as these showen and confiremed Anti- shaped, sometimes irregular, lopsided or Tumor, Anti-Cancers curved, due to improper carper development or (Prostate,Breast,Liver,Lung,Colon Cancers), insect injury. The size ranges from 10-30 cm Anti-Carcinogenic activities in-vitro, in-vivo long and up to 15 cm in width and the weight may various cells lines, Animal clinical trail studies. be up to 4.5-6.8 kg.(Minarni et al., 2017; Petal et (detail showen in Fig.:-3.a,b,c and Table-1,2 &3, al., 2016; Adewole et al., 2006) Sr. N0.-3)

Table-1 :Botanical / Scientific and Local / ASU Name of study plants

Sr. Botanical and Scientific Name Local or Reported References N0. ASU. Name

01 Taxus baccataL. or Talispatr, Talis Patta / Zarnab / Shakya, 2016; Taxus baccataThunb. Taxus Singh et al.,2013; Kainsaet al.,2012; Bishtet al.,2011; Sakarkaret al.,2011; Reddy et al., 2009; Shoeb , 2006; Hojjat et al., 2003; Rates,2001

02 Catharanthusroseus(L.) G. Don Sadabahar Roy et al., 2017; Shakya, 2016; Singh et al.,2013; Priyadarshini,2012; Bishtet al.,2011; Huang et al.,2004; Noble,1990

03 Annona muricataL. Graviola or Laxmanphal Gavamukulyaet al., 2017; Abdullah et al.,2017; Minarni et al.,2017; Faruq et al., 2016; Patel et al.,2016; Rosdiet al.,2015;

IJTCM: https://escipub.com/international-journal-of-traditional-and-complementary-medicine/ 6 Pawan Kumar Sagar et al., IJTCM, 2020, 5:22 Table-2: Medicinal and Therapeutic potential, uses of studied medicinal plants: Sr. Name of Medicinal Part Active phytochemical Medicinal, N0. plant used constituents therapeutic potential and uses In-vitrocell lines and 01 Taxus baccataLinn or Arial or Taxanes-Alkaloids(Taxol In-vivo and pharmacological Taxus baccataVar. Leaves and Taxotere),Larotaxol, reported confirmation, and nab-Paclitaxol Anti-Tumor, Anti- Bark Cancer (Bladder, pancreatic,Ovarian and breast cancer)and Anti- Carcinogenic

Arial or Vinca-Alkaloid as In-vitro cell lines and 02 Catharanthus Vinblastine, Vincristine, In-vivo and roseus(L.) G. Don Vinorelbine, Vinflunine, pharmacological catharanthine and reported confirmation, vindoline alkaloids, Anti-Tumor (Breast, Steroids, Saponin, Colon, Cervical, neck Cynogenic glycosides and Head,Anti- ,Cardiac glycoside, Cancer(Leukemias, Flavonoids and Phenols testicular, Breast, ovary, cervix, lung, rectum, testis cancer and Colon Cancers) Anti-Carcinogenic

Fruits Muricin J, Muricin K, In-vitro cell lines and 03 Annona muricataL. and Muricin L, Cinnamic acid In-vivo and Leaves derivative, Coumaric acid pharmacological hexose, 5-Caffeoylquinic reported acid, Annomuricin A, confirmation,Anti- Annomuricin B, Tumor, Anti-Cancers Annomuricin C, (Prostate, Breast, Annomuricin E, Liver, Lung, Colon Annomutacin, Annhexocin, Cancers) Muricapentocin, (2-4-cis)- isoannonacin,(2,4-trans)- isoannonacin, Muricatocin A, Muricatocin B, Muricatocin C, Giganletronenin, Annonacin A, Annopentocin A, Annopentocin B, Annopentocin C etc.

IJTCM: https://escipub.com/international-journal-of-traditional-and-complementary-medicine/ 7 Pawan Kumar Sagar et al., IJTCM, 2020, 5:22 Table - 3: In-vivo and In-vitro Anticancer and Anti tumor studies selective medicinal plants Plant Part Subject of Study Effect Reference

01. Taxus baccataL. orTaxus baccataThunb. : Ethyl alcoholleaves Carcinogenic toxicity of Wister Inhibit of changes behavioral Patel et al., 2011 extracts rats, guineapigs and albino and autonomic profiles and rats any sign of toxicity or mortality up to max. concentration dose Young steam and Different callus cancer cells Prevention of induced Callus Golenianski female gametophyte culture of Taxus baccataand ME,2000 extracts Taxus x media Aqueous extract of arial Liver and Kidney tissues of Prevention of Carcinogenicity Joshi et al., 2014 and leaves parts mice induced by DEN in TB alone and TB + CUD Aqueous and hydro- Different cancer cells Treatment and prevention of Bisht et al., 2011 alcoholic extracts of leukaemia and breast, ovary, and arial and leaves parts colon and lung cancer tissues Skarkar and contain Taxanes- growth Deshmukh, 2011 (Taxoland Taxotere) Hydro-alcoholic Cytotoxic effects of human Prevention and Inhibitory Kainsa at el., 2012 extracts of fruits or bark tumor cells activities of MDAMB-468 cells, and Hojjat at el., parts KB cells and Hela cell 2003 Extract and isolated Breast cancer cell (MCF-7 and Prevention of Breast cancer, Kainsa at el., 2012 (natural occurring 2- MDA-MB-231)and normal structurally observed and DAT-J)bark part Human Kidney epithelial (HEK cinnamoyl C-5 and acetyl C-10 Shoeb M, 2006 -231)cells groups prevent and control cancer growth activity Extract and isolated Brain tumors of DMBA-induced Prevention, regression and Kainsa at el., 2012 (natural occurring 2- rats control of Brain mammary and DAT-J)bark part tumors Reddy et al., 2009

02. Catharanthus roseus(L.)G.Don : Methanol leaves ATStrain-AtSI0105, Inhibited and reduction of max. Sayeed et al., 2014 extract AtAc0114,AtTA0112, Tumor concentration in Tumor cells and cells Rasheed ,2014 Methanol extract of HCT-116 Cancer cells, Bioassay guided isolation of Siddiqui et al ., Arial part Applied MTT assay active compounds 2010 catharanthine and vinodaline and its apoptosis inducing effect, IC50 value was foundas in most promising cytotoxicity activity in its applied concentration Aqueous and methanol MCF-7 Breast cancer Inhibited of Cancer cells and Sudevan et al., leaves, steam extracts cells,Applied MTT assay stabilization of disease 2017 Arial part extract Human Tumor cells, by NF- Vinca alkaloids inhibited of Bisht et al., 2011 Kb/IkB pathway various Tumor cells and and stabilization of disease Huang et al., 2004

03. Annona muricataL. Ethyl acetate extract of MCF-7 Breast cancer cells, Bioassay showed isolate Sir- Minarni et al., 2017 endophytic fungi Applied MTT assay G5, Its apoptosis inducing isolated from plant effect, IC50 value was found as leaves in most promising cytotoxicity activity in its applied concentration MCF-7, MDA-MB-231 and 4T1 Prevented and revealed a Syed Nejmuddin et Breast Cancer cells,Applied varied potency IC50 from the al., 2016 MTT assay anti-proferative assay and investigated, promoted anti- Leaf aqueous extract cancer effects.

IJTCM: https://escipub.com/international-journal-of-traditional-and-complementary-medicine/ 8 Pawan Kumar Sagar et al., IJTCM, 2020, 5:22 Mice tumor Cells Prevented, Inhibited and Syed Nejmuddin et performed control of T-cells, al., 2016 tumor growth from applied Clenogenic assay Ethyl acetate extract of Lung A549 Cancer Cells Mitochondrial-mediated Patel et al., 2016 the leaves apoptosis, cell cycle arrest at and Hansra et al., G1 phase 2014 Ethyl acetate extract of Colon HT-29 and HCT-116 Mitochondrial-mediated Patel et al., 2016 the leaves cancer cells apoptosis, cell cycle arrest at and G1 phase , suppression of Moghadamtousi et migration and invasion al., 2015 Water extract of the Rat’s prostate cancer cells reduction of prostate size Patel et al., 2016 leaves and Gouemoet al., 2009 Ethanolic extract of the Breast tissues of mice Prevention of DMBA-induced Patel et al., 2016 leaves DNA damage and Adeyemi et al., 2009 Ethanolic extract of the DMBA/ croton oil induced mice Suppression of tumor initiation Patel et al., 2016 leaves skin papilloma genesis and promotion and Adeyemi et al., 2009 Ethanolic extract of the DMH induced colon cancer Reduction of ACF formation Patel et al., 2016 leaves and Florence et al., 2014 Ethanolic extract of the K562 chronic myeloid Induction of apoptosis Patel et al.,2016 leaves leukemia cells andElisya etal., 2014 Leaves boiled in water Metastatic breast cancer Stabilization of disease Patel et al., 2016 and Adeyemiet al., 2008 Ethyl acetate extract of Azoxymethane induced colon Reduction of ACT Formulation Patel et al., 2016 the leaves cancer and Ahalya et al., 2014

Conclusion: drugs from medicinal plants which possess In Asian countery enclouding India, several remarkable medicinal potential based herbs, medicinal plants were traditionaly used anticancerous and antitumors activities for for preventing since ancient time, cure the health surving a novel anticancers and antitumors and treatment of several ailments inclouding herbal drugs,assure complete prevention and cancers and tumors without any adverse effect curing of very dangerous and painful diseases of and toxicity. These plants possess various cancers and tumors to world public health. This bioactive marker compounds having rich source review had given some of the plants possessing of medicinal potential anti-cancers, anti-tumors authentical database anticancer and antitumor activities. The selective medicinal plants invesitigated and reported In-vitro and In-vivo presented in this article have versatile activities.This article can help and provide maracules remedial, medicinal herbs properties referancial supporting avidance research data’s against cancers and tumors which still require a others to explore herbs to future extent and its detailed research inconcern of In-vivo cancer use in develop noble anticancers and antitumors cells line, animal, human clinical trial models, herbal drugs, variousother disease, toxicity research and development, drug designing of along with advance pharmacologyical clinical novel bioactive marker compounds and can be trial research studies. devlop synthetically in large scale of these References: medicinaly potent and effective compounds , 1. Suderan S, Paramasivam R, Sunder S, Amathy AR, Thus there is a great need in searching and Rincy R and Ramasamy V.,2017 .Evolution of manufacturing newer noble herbal extract based metabolic compounds of Catharanthus roseus and its IJTCM: https://escipub.com/international-journal-of-traditional-and-complementary-medicine/ 9 Pawan Kumar Sagar et al., IJTCM, 2020, 5:22 anticancer activity, European Journal of 14. Greenwell M, Rahman PKSM.,2015. Medicinal pharmaceutical and medical research,4(9):282-290. Plants: Their use in Anti-Cancer treatment. 2. Minarni, Artika IM, Julistione H, Bermamie N, Riyanti International Journal of Pharmaceutical Science and EI, Hasim AEZ.,2017.Anticancer activity test of ethyl Research,6:4103-4112. acetate extract of endophytic fungi isolated from 15. Moghadamtousi SZ, Rouhollahi E, Karimian, soursop leaf (Annona muricata L.), Asian pacific Fedaeinasab M, Firoozinia M, Abdulla MA et al.,2015. Journal of Tropical Medicine, 10(6):566-571. 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