Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000023265Cyc: Acidimicrobium ferrooxidans DSM 10331 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

Macromolecule Modification Fatty Acid and Amine and C1 Compound Lipid Degradation Degradation/ Polyamine Utilization and Utilization/ UDP-N-acetyl- undecaprenyl- sn-glycero-3- apo-[propionyl- a peptidoglycan L-alanyl-γ-D- Biosynthesis tRNA processing Assimilation β Assimilation - Other cob(II)yrinate a,c- Cofactor, Carrier, and Vitamin Biosynthesis oleate -oxidation α-D-glucosamine diphospho-N- 2-methylbutanoate phospho-N- CoA:carbon- 2-oxobutanoate pyruvate dimer (meso- glutamyl-L-lysyl- a protein cob(II)yrinate a,c-diamide flavin biosynthesis I (bacteria and plants) adenosylcobinamide-GDP mycothiol biosynthesis superpathway of thiamine diphosphate biosynthesis II benzimidazolyl adenosylcobamide Fatty Acid and Lipid Biosynthesis ATP roseoflavin biotin RS01180 biotin diamide biosynthesis I putrescine formate acrylonitrile acetylmuramoyl- (arachidonoyl) dioxide ligase diaminopimelate D-alanyl-D-alanine biosynthesis II (late salvage from cobinamide I biosynthesis from adenosylcobinamide-GDP a polycistronic biotin 5'-phosphate ATP-dependent (early cobalt insertion) biosynthesis I oxidation to CO degradation I γ containing) 2 oleate L-alanyl- -D- ethanolamine (ADP-forming)] Clp protease: cobalt incorporation) D-glucopyranose palmitate biosynthesis (type II fatty acid synthase) tRNA precursor acetate- acetolactate uroporphyrinogen-III GTP cob(II)inamide 6-phosphate cys benzimidazole fatty acid elongation -- saturated glutamyl-L-lysyl- penicillin- AFER_RS03920 long-chain-fatty- -CoA synthase + + uroporphyrinogen-III a [ThiS sulfur- arg formate acrylonitrile D-alanyl-D-alanine bifunctional clpX H RS01510 H uroporphyrinogen-III cob(I)yrinic acid inositol-3- UDP-N- ligase: acs glycerophosphodiester biotin/lipoate A/ penicillin- binding uroporphyrinogen-III carrier protein] nicotinate-nucleotide-- formate acid--CoA ligase: large subunit: riboflavin kinase/ C-methyltransferase: bifunctional a,c-diamide phosphate SufS family an acetoacetyl-[acp] acetylglucosamine- phosphodiesterase: B protein ligase: binding protein ATP-dependent C-methyltransferase: dimethylbenzimidazole an acetoacetyl-[acp] dehydrogenase AFER_RS07040 acetate-- AFER_RS08300 FAD synthetase: cobA 3,4-dihydroxy- adenosyltransferase: synthase: cysteine -N-acetylmuramyl- AFER_RS11220 AFER_RS05135 protein 2: mrdA Clp protease cobA a tRNA precursor a tRNA precursor with subunit alpha: fdhF [+ 2 isozymes] CoA ligase: acetolactate AFER_RS03295 precorrin-1 AFER_RS03715 desulfurase: phosphoribosyltransferase: 3-oxoacyl-[acyl- agmatine acrylamide (pentapeptide) 2: mrdA NAD(P) precorrin-1 2-butanone- AFER_RS00185 CO AFER_RS08505 glycerophosphoryl biotin/lipoate A/ proteolytic + + cobT with a 5' extension a 5' extension and 2 synthase: ilvN γ H H 4-phosphate cob(I)yrinic acid D-glyceraldehyde sufS carrier-protein] oleoyl-CoA pyrophosphoryl- diester B protein ligase: L-alanyl- -D- subunit: transhydrogenase uroporphyrinogen-III an [L-cysteine a carboxy- benzimidazole agmatinase: and a long 3' trailer a short 3' extension amidase: AFER_RS08020 roseoflavin uroporphyrinogen-III synthase/GTP a,c-diamide Ins(3)P UDP-N-acetyl- 3-phosphate reductase: fabG undecaprenol N- phosphodiesterase: AFER_RS05380 a peptidoglycan glutamyl-L- D-ala AFER_RS09035 C-methyltransferase: α desulfurase]-S- adenylated-[ThiS adenosylcobinamide- ribotide speB ribonuclease D: ribonuclease acyl-CoA/acyl-ACP AFER_RS01195 (2S)-2- adenine C-methyltransferase: cyclohydrolase II: adenosyltransferase: -D-glucosamine 1-deoxy-D- gly a (3R)-3- acetylglucosamine AFER_RS08065 with D,D cross- D-ala lysyl-D-alanine cobA sulfanyl-L-cysteine sulfur-carrier protein] GDP phosphate AFER_RS08370ribonuclease P protein [+ 2 isozymes] methylbutanoyl- diphosphate a peptide cobA a 3-oxoacyl-[acp] dehydrogenase: transferase: AMP (S)-2-aceto-2- dinucleotide H + RS09415 H + AFER_RS08720 [corrinoid cobO xylulose-5- hydroxybutanoyl-[acp] ribonuclease D: PH: rph component: CoA [propionyl- links (meso- 2,5-diamino-6- D-inositol-3-phosphate putrescine AFER_RS09140 AFER_RS11060 hydroxybutanoate precorrin-2 adenosyltranferase]- phosphate glycine 5-methylbenzimidazolyl adenosylcobamide AFER_RS08370 AFER_RS10560 acrylate ditrans,octacis- UDP CoA:carbon- diaminopimelate precorrin-2 (5-phospho-D- glycosyltransferase: adenosylcobinamide- 3-hydroxyacyl- sn-glycerol cob(II)inamide synthase: oxidase biosynthesis from adenosylcobinamide-GDP (2E,9Z)- undecaprenyldiphospho- anandamide dioxide ligase containing) AFER_RS01840 GDP ACP dehydratase a tRNA precursor with 3-phosphate precorrin-2 C(20)- ribosylamino) AFER_RS02455 ThiO: thiO 3-oxoacyl- octadecenoyl-CoA N-acetyl-(N-acetyl-β-D- (ADP-forming)] a thiocarboxylated- ribazoletransferase: FabZ: fabZ a short 3' extension F0F1 ATP pyrimidin- H + H + methyltransferase: 1-O-(2-acetamido- AIR 1-deoxy-D-xylulose [ThiS sulfur- AFER_RS02740 5-methylbenzimidazole [acyl-carrier- a tRNA precursor glucosaminyl)muramoyl- synthase 4(3H)-one 2-iminoacetate γ cobI [corrinoid 2-deoxy-α-D- 5-phosphate carrier protein] a (2E)-but-2-enoyl-[acp] protein] with a 5' extension L-alanyl- -D-glutamyl-L- sirohydrochlorin bifunctional α α nicotinate-nucleotide-- ribonuclease ribonuclease D: adenosyltranferase]- glucopyranosyl)-1D-myo phosphomethylpyrimidine Co -[ - reductase: (S)-3-hydroxy-(9Z) lysyl-D-alanyl-D-alanine precorrin-3A diaminohydroxyphosphoribosylaminopyrimidine dimethylbenzimidazole beta-ketoacyl- PH: rph AFER_RS08370 synthase ThiC: thiC thiazole synthase: (benzimidazolyl)]-Co enoyl-ACP fabG + + deaminase/5-amino-6-(5-phosphoribosylamino) cob(I)inamide -inositol 3-phosphate phosphoribosyltransferase: ACP synthase II: -octadecenoyl-CoA H RS00750 H AFER_RS05910 β-adenosylcobamide reductase uracil reductase RibD: ribD cob(I)yrinic acid cobT AFER_RS05585 a (3R)-3- quinoxaline-2- a peptidoglycan a uridine 38- an [amino-group HMP-P 5'-phosphate FabI: fabI a 2,3,4-saturated adenosylcobinamide a purine H O carbamoyl a uracil in DNA 5-amino-6-(5- a,c-diamide hydroxyacyl-[acyl- aryl-carrier protein diphosphate 2 asp dimer (E. faeciums) carrier protein]- cobalt- 2-[(2R,5Z)-2-carboxy- thiamine diphosphate salvage II adenosylcobinamide- 5-methylbenzimidazole dipyrromethane carboxyl adenylate 40 in tRNA ATP phospho-D- adenosyltransferase: fatty acyl-[acp] ribonucleoside phosphate tRNA γ sirohydrochlorin 1-(2-acetamido- bifunctional 4-methylthiazol-5(2H)- ribotide phosphate a butanoyl-[acp] 3-hydroxyacyl-carrier protein] biotin C-terminal- - sulfite RS08665 sulfite ribosylamino)uracil GDP cofactor biosynthesis 3-oxo-(9Z)- 5'-triphosphate precorrin-3B D-ribulose AFER_RS03715 2-deoxy-α-D- hydroxymethylpyrimidine ylidene]ethyl phosphate ACP penicillin- pseudouridine (L-glutamate 5- bifunctional 4-amino-2-methyl-5- Coα-[α- an apo-[hydroxymethylbilane an uncharged tRNA octadecenoyl-CoA uracil-DNA N-acetyl- 5-phosphate cob(I)yrinic acid glucopyranosyl)- kinase/ beta-ketoacyl- dehydratase acyl carrier inorganic aspartate/ornithine binding synthase: semialdehyde-2- precorrin-3B C(17)- diaminohydroxyphosphoribosylaminopyrimidine pyrimidinemethanol (benzimidazolyl)]-Co adenosylcobinamide- synthase]-L-cysteine acetyl-CoA C- bifunctional glycosylase: gamma- bifunctional a,c-diamide 1D-myo-inositol phosphomethylpyrimidine ACP synthase II: FabZ: fabZ protein: acpP diphosphatase: carbamoyltransferase: protein AFER_RS10750 biotin--[acetyl- yl)-L-glutamate methyltransferase: deaminase/5-amino-6-(5-phosphoribosylamino) bifunctional β-adenosylcobamide GDP acyltransferase: adenosylcobinamide AFER_RS02255 glutamyl- sulfite RS05780 sulfite 3,4-dihydroxy- adenosyltransferase: N-acetyl-1-D-myo kinase: thiD AFER_RS05585 acyl carrier AFER_RS07715 AFER_RS08605 2: mrdA RluA family CoA-carboxylase] cobalt-factor III cobJ uracil reductase RibD: ribD 2-(2-carboxy-4- hydroxymethylpyrimidine ribazoletransferase: AFER_RS07055 kinase/ uracil-DNA phosphate 2-butanone- cobO -inositol-2-amino- a [hydroxymethylbilane protein: RdgB/HAM1 family pseudouridine ligase: 5-amino-6-(5- HMP-PP methylthiazol-5- kinase/ AFER_RS02740 adenosylcobinamide- aspartate glycosylase: an [amino-groupreductase: precorrin-4 4-phosphate 2-deoxy-α-D- adenosylcobalamin synthase] ES intermediate a 3-oxohexanoyl-[acp] acetyl-CoA C- non-canonical synthase: AFER_RS10855 phospho-D- yl)ethyl phosphate 2 lipoprotein posttranslational AFER_RS07810 carbamoyltransferase a peptidoglycan adenosylcobinamide salvage from cobalamin phosphomethylpyrimidine enoyl-ACP acyltransferase: phosphate AFER_RS04220 carrier protein]-argC serine serine synthase/GTP glucopyranoside Coα-[α-(5- modification Pentose Phosphate Pathways purine NTP AFER_RS06220 γ RS05440 cobalt-precorrin-4/ ribitylamino)uracil kinase: thiD hydroxymethylbilane reductase guanylyltransferase: catalytic subunit: tetramer with a D-ala 38- C-terminal- - cyclohydrolase II: deacetylase: 3-oxotehexanoyl- a trans-2- AFER_RS01350 pyrophosphatase: a pseudouridine thr thr bifunctional cob(I)alamin thiamine methylbenzimidazolyl)]- synthase: hemC a 2,3,4-saturated FabI: fabI AFER_RS02735 a quinoxaline-2- AFER_RS08815 D,D cross-link biotinyl-5'- (5-phospho- cobalt-precorrin-3 precorrin-4 C(11)- [acyl-carrier enoyl-[acyl- a [prolipoprotein]- rdgB an apyrimidinic uracil 40 in tRNA AFER_RS08720 superpathway of tetrahydrofolate biosynthesis adenosylcobinamide AFER_RS08340 phosphate HMP-P Coβ-adenosylcobamide fatty acyl-[acp] pentose phosphate pathway (7Z)-hexadecenoyl-CoA carboxyl-[aryl- (Enterococcus adenylate L-glutamyl)- methyltransferase: a [hydroxymethylbilane protein] acyl-CoA/acyl-ACP carrier protein] L-cysteine adenosyl- AMP 1-deoxy-L- synthase: thiE 5'-phosphate site in DNA faecium) AFER_RS04155 kinase/ GlcN-Ins synthase] ES intermediate reductase: fabG dehydrogenase: carrier protein] L-glutamate a metal a metal bifunctional 5-(2-hydroxyethyl) 3 prolipoprotein D-glucopyranose cobinamide glycero-tetrulose ARP adenosylcobinamide- acyl-CoA/acyl-ACP N-carbamoyl- RS02440 AFER_RS09140 phosphate a purine + cation cation 4-phosphate cob(II)alamin hydroxymethylpyrimidine -4-methylthiazole hydroxymethylbilane a (3R)-3- diacylglyceryl 6-phosphate dehydrogenase: phosphate H L-aspartate precorrin-5 GTP phosphate L-cysteine : 1 D- ribonucleoside thiamine phosphate kinase/ synthase: hemC transferase: AFER_RS09140 guanylyltransferase: myo-inositol 2- cob(I)yrinic acid Coα-[α-(5- hydroxyhexanoyl-[acp] glucose-6- cobalt-precorrin-4 6,7-dimethyl-8- phosphomethylpyrimidine AFER_RS08075 5'-diphosphate GTP AFER_RS02735 amino-2-deoxy-α- a,c-diamide thiamine- methylbenzimidazolyl)]- a [hydroxymethylbilane 3-hydroxyacyl- enoyl-ACP phosphate (2E,7Z)- a metal a metal ribityllumazine kinase: thiD a [prolipoprotein]- RS01590 cobalt-precorrin-4/ D-glucopyranoside adenosyltransferase: 4-methyl-5-(2- Coβ-adenosylcobamide synthase] ES intermediate ACP dehydratase reductase dehydrogenase: hexadecenoyl-CoA synthase: cyclohydrolase I: adenosyl-cobinamide phosphate 4 S-1,2-diacyl-sn- cation cation precorrin-4 C(11)- AFER_RS09885 ligase: AFER_RS03715 kinase: thiL HMP-PP phosphooxyethyl) FabZ: fabZ FabI: fabI zwf a ring-opened 7- 7,8-didemethyl- 3-(D-glyceryl) a DNA containing DNA with adenine:7,8- α ε β precorrin-6A AFER_RS08715 phosphate hydroxymethylbilane glyceryl-L-cysteine a [protein]- phosphoenol N ,N -diacetyl-lysyl- N- -aspartyl- methyltransferase: 7,8- AFER_RS06335 thiazole glucose-6- methylguanine 8-hydroxy-5- -diphospho- an apurinic/ FAD dihydro-8- 3-sulfino-L-alanine cob(I)yrinic acid synthase: hemC L-threonine dGDP pyruvate D-alanyl-D-alanine L-arginine AFER_RS04155 dihydroneopterin bifunctional thiamine diphosphate a (2E)-hex-2-enoyl-[acp] in DNA deazariboflavin 5'-guanosine apyrimidinic site oxoguanine mismatch a,c-diamide signal peptidase phosphate (S)-3-hydroxy-(7Z) a metal RS04430 a metal 6,7-dimethyl-8-(1- 3'-triphosphate adenosylcobinamide deacetylmycothiol thiamine a holo-[hydroxymethylbilane cobalt- adenosyltransferase: folate transformations III (E. coli) II: AFER_RS06225 dehydrogenase: -hexadecenoyl-CoA cation cation D-ribityl)lumazine kinase/ phosphate synthase] enoyl-ACP FAD:protein FMN penicillin- isoaspartyl precorrin-5A mycothiol cobO long-chain fatty AFER_RS07865 bifunctional DNA- 2-phospho- endonuclease A/G-specific SufS family riboflavin adenosylcobinamide- synthase: thiE reductase an (S-diacyl- transferase: binding peptidase/L- precorrin-6B synthase: cob(II)alamin- CDP-diacylglycerol acid activation a lipoprotein 6-phospho formamidopyrimidine L-lactate III: nth adenine pyruvate cysteine synthase: phosphate a tetrahydrofolate FabI: fabI sn-glyceryl) AFER_RS05125 protein asparaginase: 7,8- mshD [corrinoid biosynthesis I signal peptide D-glucono- glycosylase/ transferase: glycosylase: kinase: pyk desulfurase:chloride RS05325 chloride AFER_RS08725 a long-chain -L-cysteinyl- bifunctional DNA- FAD:protein FMN 2: mrdA AFER_RS05470 dihydroneopterin guanylyltransferase: adenosyltranferase] thiamine phosphate 1,5-lactone 3-oxo-(7Z)- DNA-(apurinic AFER_RS03805 AFER_RS06880 sufS cobalt- AFER_RS02735 a hexanoyl-[acp] fatty acid [apolipoprotein] formamidopyrimidine transferase: riboflavin 3'-phosphate mycothiol methionine DHAP long-chain-fatty- 6-phosphogluconolactonase: hexadecenoyl-CoA or apyrimidinic precorrin-5B glycosylase/ adenosylcobinamide- thiamine- synthase: metH acid--CoA ligase: AFER_RS10925 site) lyase: mutM AFER_RS06685 Nα,Nε-diacetyl- glycine cleavage system beta-ketoacyl- acetyl-CoA C- oxidized 3PG- DNA-(apurinic an apurinic site pyruvate cobalt-precorrin- precorrin-7 bifunctional phosphate AFER_RS04120 lysyl-D-alanine D-ala arg asp sulfite chloride RS01315 chloride GDP cob(I)alamin- ACP synthase II: D-gluconate acyltransferase: or apyrimidinic dGTP ala 5B (C(1))- riboflavin kinase/ kinase: thiL protein GcvH: gcvH sn-glycerol a peptide factor 420-0 GMP adenine within DNA AFER_RS05585 [+ 2 isozymes] an N-acyl-(S- AFER_RS07055 a [DNA]- 2,6-diamino-4- site) lyase: mutM a [protein]-FMN- methyltransferase: FAD synthetase: D-erythro-7,8- [corrinoid serine [+ 4 isozymes] bifunctional 3-phosphate a long-chain 6-phosphate a 5'-phospho- chorismate diacyl-sn-glyceryl) acetyl-CoA C- nucleotide- hydroxy-5-(N-methyl) 4-oxo-2-pentenal AMP L-threonine AFER_RS04160 AFER_RS03295 dihydroneopterin adenosyltranferase] thiamine diphosphate a 7,8-dihydrofolatehydroxymethyltransferase:a 5-methyltetrahydrofolate 5,10-methylene- fatty acyl-CoA decarboxylating 6- [DNA] cob(I)yrinic acid a 3-oxooctanoyl-[acp] -L-cysteinyl- acyltransferase: 3'-phosphate formamidopyrimidine heme b RS01715 heme b dihydroneopterin aminodeoxychorismate/ pyridoxal 5'-phosphate biosynthesis I AFER_RS09320 tetrahydrofolate phosphogluconate a 3'-terminal a 5'-phospho- cobalt- NAD de novo biosynthesis a,c-diamide [lipoprotein] AFER_RS01350 precorrin-8x FMN aldolase: anthranilate synthase dehydrogenase/ a (6S)-5-formyltetrahydrofolate dehydrogenase: gnd unsaturated sugar [DNA] precorrin-6A I (from aspartate) adenosyltransferase: 3-oxooctanoyl- a 1-acyl-sn AFER_RS09875 component II: D-erythrose 5,10-methylene- D-ribulose precorrin-8X bifunctional AFER_RS03715 [acyl-carrier -glycerol 3- (5Z)-tetradecenoyl-CoA 6-(hydroxymethyl) AFER_RS00425 4-phosphate tetrahydrofolate 5-phosphate a sugar RS08165 a sugar methylmutase: riboflavin kinase/ 5,10- protein] phosphate a 7,8-dihydro- 7,8-didemethyl- enolpyruvoyl- an sn-glycero-3- an N-terminal- -7,8-dihydropterin asp cob(I)yrinic acid coenzyme A biosynthesis cyclohydrolase: acyl-CoA/acyl-ACP a nucleoside phosphoenol AFER_RS04130 FAD synthetase: 4-amino-4- methylenetetrahydrofolate reductase: fabG 1-acyl-sn-glycerol- queuosine biosynthesis I (de novo) 8-oxoguanine 8-hydroxy-5- 2-diphospho- phospho-N-(acyl) 2-oxoglutarate isochorismate L-methionyl-L- a DNA segment L-selenocysteine cobalt- L-aspartate a,c-diamide AFER_RS01665 ribulose- ribose 5- dehydrogenase: triphosphate RNA dADP pyruvate AFER_RS03295 2-amino-4-hydroxy-6- deoxychorismate I (prokaryotic) reductase: AFER_RS01670 3-phosphate in DNA deazariboflavin 5'-guanosine valyl-[protein] DDE-type precorrin-6B oxidase: adenosyltransferase: a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate a (3R)-3- ethanolamine hydrogenobyrinate hydroxymethyldihydropteridine 4-phospho- phosphate 3- phosphate AFER_RS09140 a sugar RS05090 AFER_RS04935 cobO (R)-4'- hydroxyoctanoyl-[acp] acyltransferase: preQ integrase/ a sugar cobalt-precorrin- FAD 0 epimerase: isomerase diphosphokinase: folK D-erythronate phosphopantothenate AFER_RS11100 (2E,5Z)- 2-succinyl-5- transposase/ 15 hydrogenobyrinate 2-iminosuccinate adenosylcob(III) bifunctional NADPH-dependent 7- DNA-directed type I methionyl 6B (C )- (7,8-dihydropterin- bifunctional 3-hydroxyacyl- rpe B: rpiB tetradecenoyl-CoA bifunctional DNA- 2-phospho- glycerophosphoryl SufS family erythronate- cyano-7-deazaguanine enolpyruvyl- RNA polymerase: recombinase: methyltransferase a,c-diamide synthase: alamin-[corrinoid phosphopantothenoylcysteine 5,10-methylene- ACP dehydratase 1-acyl-sn-glycerol- formamidopyrimidine L-lactate diester pyruvate aminopeptidase: cysteine 6-yl)methyl 4-aminobenzoate quinolinate 4-phosphate reductase QueF: queF 6-hydroxy-3- AFER_RS12475 AFER_RS04150 adenosyltranferase] decarboxylase/ tetrahydrofolate FabZ: fabZ 3-phosphate D-xylulose D-ribose 5- glycosylase/ transferase: phosphodiesterase: rpoB kinase: pyk map desulfurase:a sugar RS06840 a sugar [decarboxylating]: diphosphate synthase dehydrogenase: preQ cyclohexene-1- hydrogenobyrinate cob(I)yrinic acid dehydrogenase/ acyltransferase: 1 5-phosphate phosphate DNA-(apurinic AFER_RS03805 AFER_RS02030 recombinase sufS AFER_RS10890 NadA: nadA AFER_RS07920 phosphopantothenate-- AFER_RS08065 carboxylic-acid a,c-diamide a,c-diamide cysteine ligase CoaBC: coaBC 5,10-methylene- a (2E)-oct-2-enoyl-[acp] AFER_RS07380 or apyrimidinic [+ 2 isozymes] RecA: recA dihydropteroate (R)-4'- 2-methyladeninyl adenosylcobamide tRNA guanosine(34) glycerophosphodiester synthase: menD an N-terminal a DNA segment cobalt-precorrin-7 quinolinate adenosyltransferase: (3R)-3-hydroxy-2-oxo- tetrahydrofolate a 1,2-diacyl- (3E,5Z)-tetradeca- (S)-3-hydroxy-(5Z) site) lyase: mutM cobaltochelatase synthase: folP phosphopantothenoyl- biosynthesis from adenosylcobinamide-GDP transketolase: tkt dehydro phosphodiesterase: pyruvate met L-valyl-[protein] in reverse Mg 2+ RS02435 Mg 2+ AFER_RS03715 D-glyceraldehyde 4 phosphooxybutanoate cyclohydrolase: enoyl-ACP sn-glycerol transglycosylase Tgt: tgt 3,5-dienoyl-CoA -tetradecenoyl-CoA dATP selenide subunit CobN: cobN dihydropteroate pyruvate L-cysteine factor 420-0 AFER_RS11220 orientation ala bifunctional cobalt- carboxylating 3-phosphate phosphoserine AFER_RS01665 reductase 3-phosphate a 7-aminomethyl-7- acyl-CoA GMP 2-succinyl-5-enolpyruvoyl- RNA synthase: folP cob(I)yrinic acid bifunctional 2-methyladenine D-sedoheptulose D-glyceraldehyde a [DNA]- phosphatidate 34 thioesterase a 5'-phospho- 7,8-dihydro- 6-hydroxy-3-cyclohexene- precorrin-7 (C(5))- cob(II)yrinate nicotinate- a,c-diamide transaminase: FabI: fabI deazaguanosine in tRNA 7-phosphate 3-phosphate nucleotide- 4-oxo-2-pentenal phosphopantothenoylcysteine an N 10 -formyltetrahydrofolate cytidylyltransferase: II: tesB [DNA] 8-oxoguanine 1-carboxylate a reduced methyltransferase a,c-diamide nucleotide 1-deoxy-D- AFER_RS07930 nicotinate-nucleotide-- tRNA preQ1(34) S- 3'-phosphate sn-glycerol an N- 7,8- adenosyltransferase: decarboxylase/ an octanoyl-[acp] AFER_RS11525 3-oxo-(5Z)- H O c-type CbiE/decarboxylating diphosphorylase: xylulose-5- 4-phosphooxy- dimethylbenzimidazole adenosylmethionine (3E,5Z)- 3-phosphate acylethanolamine 2 adeninyl adenosylcobamide biosynthesis dihydropteroate cobO phosphopantothenate-- transaldolase: tal tetradecenoyl-CoA cytochrome cytochrome cobalt-precorrin- nadC phosphate phosphoribosyltransferase: a CDP- tetradecadienoate an oxidized from adenosylcobinamide-GDP folylpolyglutamate L-threonine cysteine ligase CoaBC: coaBC beta-ketoacyl- ribosyltransferase- acetyl-CoA C- c oxidase 6B (C(15))- adenosylcobalamin synthase: cobT diacylglycerol isomerase QueA: queA O c-type synthase: NaMN ACP synthase II: D-erythrose acyltransferase: 7,8-didemethyl- L-lactyl-2- a mature (E)-4-hydroxy-3- 2 methyltransferase AFER_RS02455 4'-phosphopantetheine F6P a purine base an L-asparaginyl- acytochrome reduced AFER_RS10875 4-phosphate glycerophosphoserine H O glu (S)-4-amino-5- AFER_RS05585 34 AFER_RS01350 8-hydroxy-5- diphospho- peptidoglycan 2 a tRNA methylbut-2-en- ser sec CbiT: adenine molybdopterin biosynthesis an epoxyqueuosine in tRNA lesion in DNA (n) Asn a tRNA H O cbb3-type c-type nicotinate-nucleotide 2-methyladenine GTP oxopentanoate [tRNA ] 2 AFER_RS10890 7,8-dihydrofolate 1-deoxy-D- 3-amino-1- pantetheine- acetyl-CoA C- deazariboflavin 5'-guanosine (meso-DAP 1-yl diphosphate cytochrome adenylyltransferase: adenosylcobinamide- ribotide phosphate transketolase: tkt flavodoxin- cytochrome an oxidized monoglutamate xylulose 5- hydroxyacetone phosphate a 3-oxodecanoyl-[acp] epoxyqueuosine acyltransferase: containing) nicotinate-nucleotide-- AFER_RS04070 GDP dependent O c oxidase c-type NAD biosynthesis from 2-amino- reductase: bifunctional DNA- glycerophosphoryl 2 cobalt-precorrin-8 dimethylbenzimidazole phosphate 1-phosphate adenylyltransferase: ATP biotin-carboxyl carrier AFER_RS07055 2-phospho- glutamyl- aminoacyl-tRNA (E)-4-hydroxy- serine- nicotinate adenine 3-carboxymuconate semialdehyde cys 3-oxodecanoyl- AFER_RS10940 D-glyceraldehyde formamidopyrimidine diester GTPase cytochrome phosphoribosyltransferase: coaD protein assembly (3Z)-dodec- L-lactate endolytic tRNA hydrolase: 3-methylbut- -tRNA dinucleotide adenosylcobinamide- [acyl-carrier 3-phosphate glycosylase/ phosphodiesterase: HflX: hflX 2-amino-3- 34 3-enoyl-CoA transferase: transglycosylase reductase: AFER_RS08265 2-enyl- ligase: cobT 3'-dephospho- GDP SufS family molybdopterin- protein] a [biotin carboxyl- a queuosine in tRNA DNA-(apurinic AFER_RS08065 [+ 4 isozymes] a 7,8-dihydrofolate NAD+ synthase: NAD+ synthase: carboxymuconate- AFER_RS03805 MltG: mltG hemA CoA ribazoletransferase: cysteine synthase GTP reductase: fabG carrier protein]-L-lysine or apyrimidinic diphosphate serS AFER_RS01275 AFER_RS01275 6-semialdehyde glycerophosphodiester adenine ribotide pyridoxine dephospho- AFER_RS02740 desulfurase: adenylyltransferase 2-C-methyl-D-synthase: ispG cobyrinate biotin/lipoate A/ site) lyase: mutM phosphodiesterase: H + adenosylcobinamide- phosphate 5'-phosphate a (3R)-3- phosphate tRNA Asn + thiamine diphosphate CoA kinase: sufS MoeB: moeB GTP 3',8- B protein ligase: a mature GlcNAc-1,6- GDP asn erythritol-2,4- GDP NAD hydroxydecanoyl-[acp] (2E)-dodec- oxidized AFER_RS11220 an L-glutamyl- an L-seryl- cobyrinate A,C- quinolinate biosynthesis I (E. coli) coaE Coα-[α-(2- an [L-cysteine a carboxy-adenylated peptidoglycan anhMurNAc- cyclodiphosphate cyclase AFER_RS05135 N 6 -L-threonylcarbamoyladenosine 37 a [DNA]- factor 420-0 GMP (n) [tRNA Glu ] sec methyladenin-9-yl)]-Co desulfurase]-S- [small subunit of 3-hydroxyacyl- 2-enoyl-CoA a 5'-phospho- a modified γ [tRNA ] diamide synthase: MoaA: moaA [+ 2 isozymes] 4-oxo-2-pentenal (meso-DAP L-Ala- -D-Glu- adenosylcobinamide- a tetrahydrofolate carboxylating 2-[(2R,5Z)- coenzyme A β -modified tRNA biosynthesis Glycolysis nucleotide- [DNA] nucleobase AFER_RS04150 phosphopantothenate biosynthesis I -adenosylcobamide sulfanyl-L-cysteine molybdopterin synthase] (8S)-3',8-cyclo-7,8- ACP dehydratase a [biotin carboxyl- sn-glycerol containing) DAP-D-Ala GDP nicotinate- 2-carboxy-4- 3'-phosphate ser cob(II)yrinate 5'-phosphate dihydroguanosine FabZ: fabZ carrier protein]-N 3-phosphate ribazoletransferase: nucleotide methylthiazol-5(2H PLP glycolysis I (from glucose 6-phosphate) molybdopterin 5'-triphosphate 6 thr a,c-diamide 3-methyl-2-oxobutanoate )-ylidene]ethyl -biotinyl-L-lysine (S)-3- AFER_RS02740 diphosphorylase: HMP-PP synthase cyclic pyranopterin a (2E)-dec-2-enoyl-[acp] L-threonylcarbamoyladenylate nadC phosphate D-glucopyranose hydroxydodecanoyl-CoA adenosylcobalamin biosynthesis 3-methyl-2-oxobutanoate α α sulfurtransferase: monophosphate synthase: AFER_RS09325 a [ribosomal a peptidoglycan an N-terminal- a peptide with 34 α α Co -[ -(2- a [DNA]-3'- + a 5'-phospho- + an adenosine Co -[ -(adenin-9-yl)]- NAD salvage pathway I (PNC VI cycle) enoyl-ACP (L-threonylcarbamoyl) 6-phosphate a sulfurated NAD glycerophosphoglycerol menadione NADH H a RNA-DNA hybrid from adenosylcobinamide-GDP I hydroxymethyltransferase: moeB synthase protein S12] dimer (S. aureus) L-methionyl- an N-terminal Arg2 Coβ-adenosylcobamide NaMN thiamine methyladenin-7-yl)]-Co a [biotin carboxyl- adenylate hydroxyl [DNA] in [tRNA ] reductase [sulfur carrier] 89 glycyl-[protein] panB phosphate β-adenosylcobamide MoaC: moaC glucose-6- L-aspartate L-methionine Flp pilus heme a biosynthesis 5'-phosphate NAD + a thiocarboxylated FabI: fabI carrier-protein dimer]- tRNA (adenosine(37)-N6)- 5,6-dimethylbenzimidazole nicotinate-nucleotide cyclic pyranopterin 6 phosphate assembly 2-dehydropantoate synthase: [small subunit of N -biotinyl-L-lysine threonylcarbamoyltransferase 3-oxododecanoyl-CoA NAD- glycerophosphodiester NADH-quinone ribonuclease HI: penicillin- adenylyltransferase: phosphate isomerase: type I methionyl type I methionyl complex thiE molybdopterin synthase] a decanoyl-[acyl-carrier protein] acetyl-CoA acetyl-CoA complex: tsaE tsaD MiaB/RimO family dependent phosphodiesterase: oxidoreductase: AFER_RS03675 binding protoheme nicotinate-nucleotide-- AFER_RS04070 pgi acetyl-CoA C- ATPase NAD+ synthase: an N 6 -L- radical SAM protein aminopeptidase: aminopeptidase: protoheme IX Coα-[α-(adenin-7-yl)]- dimethylbenzimidazole menaquinol-11 biosynthesis menaquinol-10 biosynthesis carboxylase carboxylase DNA ligase AFER_RS11220 AFER_RS01880 ribonuclease HII: component nicotinate adenine AFER_RS01275 menaquinol-7 biosynthesis beta-ketoacyl- 37 acyltransferase: methylthiotransferase: 2: mrdA map map phosphoribosyltransferase: thiamine NAD+ synthase: carboxyltransferase biotin carboxylase threonylcarbamoyladenine LigA: ligA AFER_RS01890 AFER_RS03020 farnesyltransferase: Coβ-adenosylcobamide dinucleotide F6P AFER_RS07055 glycerophosphoryl TadA: tadA all-trans- ACP synthase II: in tRNA AFER_RS03360 34 cobT β all-trans- phosphate AFER_RS01275 all-trans- subunit: subunit: diester nuoG nuoH an inosine AFER_RS08855 -alanine 1,4-dihydroxy- AFER_RS05585 acetyl-CoA C- (R)-pantoate undecaprenyl 1,4-dihydroxy- NAD+ synthase: nicotinate adenine 1,4-dihydroxy- S-adenosyl-L- decaprenyl AFER_RS05285 AFER_RS03755 nuoI nuoK a peptidoglycan an N-terminal Arg2 ferroheme o α-ribazole thiamine- NMN heptaprenyl phosphodiesterase: in [tRNA ] adenosylcobinamide- diphosphate 2-naphthoate AFER_RS01275 dinucleotide 2-naphthoate methionine salvage II molybdopterin diphosphate 2-naphthoate a [carboxyl-carrier class II fructose- acyltransferase: a [ribosomal [DNA] NMN DNA a nucleoside 5'- with D,D cross- D-ala met glycyl-[protein] met a peptide 5'-phosphate phosphate diphosphate AFER_RS08065 GDP a 3-oxododecanoyl-[acp] 6 bisphosphatase: AFER_RS01350 5'-deoxyadenosine an unsulfurated AMP monophosphate link (S. aureus) heme A synthase: pantoate--beta-alanine kinase: thiL protein dimer]-N - met protein S12]-3- 5,6-dimethylbenzimidazole + nicotinate-nucleotide [sulfur carrier] 1,4-dihydroxy- NAD 1,4-dihydroxy- 1,4-dihydroxy- carboxybiotinyl-L-lysine N-end rule pathway I (prokaryotic) glpX methylsulfanyl- NAD + menadiol AFER_RS00980 biosynthesis I (aerobic) ligase: AFER_RS09865 thiamine adenylyltransferase: SAH 3-oxododecanoyl- decanoyl-CoA adenosylcobinamide- 2-naphthoate 2-naphthoate 2-naphthoate L-aspartate 89 glycerol sn-glycerol diphosphate AFER_RS04070 [acyl-carrier hypothetical fructose- β-D-fructose 1,6- ferroheme i GDP polyprenyltransferase: polyprenyltransferase: adenosylhomocysteinase: polyprenyltransferase: acyl-CoA/acyl-ACP 3-phosphate riboflavin molybdenum protein] protein: bisphosphatebisphosphate ribazoletransferase: (R)-pantothenate AFER_RS08425 AFER_RS08425 AFER_RS09115 AFER_RS08425 a [protein] dehydrogenase: bifunctional riboflavin NaMN nicotinamide cofactor biosynthesis reductase: fabG AFER_RS06725 aldolase class I: heme A synthase: AFER_RS02740 L-homocysteine an N-terminal N-terminal L- AFER_RS09140 kinase/FAD synthetase: AFER_RS00905 AFER_RS00980 type III pantothenate tetrahydrofolate salvage from a (3R)-3- arginyl-[protein] a mature peptidoglycan trans,octacis sn-glycero-3- an N-terminal- an N-terminal- D-sedoheptulose molybdopterin DMKH2-10 leucyl-L-arginine NAD + an L-cysteinyl- AFER_RS03295 kinase: AFER_RS09860 DMKH2-11 5,10-methenyltetrahydrofolate demethylmenaquinol-7 class I fructose- (2E)-dec-2-enoyl-CoA (meso-diaminopimelate -decaprenyl NADPH L-methionyl-L- L-methionyl-L- F6P adenosylcobalamin lipoate methionine molybdate hydroxydodecanoyl-[acp] fatty acid biosynthesis PRPP phosphoethanolamine 1-phosphate [tRNA Cys ] hydroxyferroheme i FMN bisphosphate containing) phosphate cysteinyl-[protein] alanyl-[protein] glutamine-- 5'-phosphate ubiquinone/ biosynthesis and nicotinate synthase: metH ubiquinone/ 3-hydroxyacyl- initiation (type II) (R)-4'-phosphopantothenate a 5,10-methenyltetrahydrofolate ubiquinone/ hypothetical DHAP aldolase: fructose-6- menaquinone incorporation I phosphoribosyltransferase: menaquinone menaquinone ACP dehydratase protein: AFER_RS04615 glycerophosphoryl NAD(P)(+) class I fructose- phosphate bifunctional 5,10- biosynthesis acetyl-CoA a [protein] endolytic decaprenyl-phosphate type I methionyl type I methionyl aminoacyl-tRNA biosynthesis pncB biosynthesis met molybdopterin FabZ: fabZ an N-terminal AFER_RS06725 diester transhydrogenase bisphosphate methylene-tetrahydrofolate an octanoyl-[acp] acetyl-CoA carboxylase N-terminal L- (S)-3- transglycosylase phosphoribosyltransferase: aminopeptidase: aminopeptidase: hydrolase: transaminase methyltransferase: nicotinate methyltransferase: adenine methyltransferase: triose-phosphate (Re/Si-specific): aldolase: folate polyglutamylation dehydrogenase/5,10- octanoyl thioredoxin molybdate L-lysyl-[protein] AFER_RS08985 phosphodiesterase: AFER_RS08265 (isomerizing) FMNH AFER_RS04345 methionine dinucleotide AFER_RS04345 a (2E)-dodec-2-enoyl-[acp] carboxyltransferase leucyl-L-lysine hydroxydecanoyl-CoA MltG: mltG map map AFER_RS04615 ferroheme a 2 adenosylcobalamin AFER_RS04345 isomerase: AFER_RS08065 AFER_RS10240 : glmS methylene-tetrahydrofolate transferase: pathway adenosyltransferase: subunit: AFER_RS05285 cyclohydrolase: a [lipoyl-carrierlipA AFER_RS04390 glycerophosphodiester AFER_RS10245 D-glucosamine 5,6-dimethylbenzimidazole a tetrahydrofolate menaquinol-11 factor 420 menaquinol-7 AFER_RS08765 molybdopterin menaquinol-10 enoyl-ACP malonyl-CoA a mature peptidoglycan a mature peptidoglycan trans,octacis- AFER_RS01665 protein] N 6 - an oxidized phosphodiesterase: AFER_RS10250 an N-terminal L- an N-terminal L- 6-phosphate synthase: bluB polyglutamylation molybdotransferase reductase with (L-alanyl-γ-D- strand (non- decaprenylphospho- met met DHAP D-erythrose cys a tRNA Cys 10 thioredoxin [acyl-carrier-protein] S cysteinyl-[protein] alanyl-[protein] an N -formyltetrahydrofolate octanoyl-L-lysine NAD SAM D-glyceraldehyde reducing terminus) β-D-ribofuranose AFER_RS11220 lipoyl MoeA: AFER_RS02495 FabI: fabI -malonyltransferase: 3-oxodecanoyl-CoA glutamyl-meso-2,6- 5,6-dimethylbenzimidazole serine folylpolyglutamate oxidized phosphorylation and Respiration 3-phosphate diaminopimeloyl-D- 5-phosphate + phosphoribosylglycinamide synthase: factor 420-0 AFER_RS05565 NADH NADP hydroxymethyltransferase: synthase: coenzyme transhydrogenation MoO - a dodecanoyl-[acp] acetyl-CoA C- formyltransferase: lipA 2 demethylmenaquinol- type I alanine) tetrapeptide sn-glycerol AFER_RS09320 AFER_RS10875 10 demethylmenaquinol- thioredoxin- demethylmenaquinol- molybdopterin 2-oxoisovalerate decarboxylation to isobutanoyl-CoA acyltransferase: ethanolamine an N - AFER_RS01655 a [lipoyl-carrier F420-0:L- NAD + 3-phosphate 6 biosynthesis I disulfide 9 biosynthesis 8 biosynthesis I a malonyl-[acp] glyceraldehyde- formyltetrahydrofolate 6 glutamate NAD(+)/ cofactor AFER_RS07055 a 5,10- protein]-N -[(R) reductase: all-trans- beta-ketoacyl- acyl-ACP an [apo BCAA 3-phosphate a tetrahydrofolate folylpolyglutamate all-trans- a tetrahydrofolate ligase: cofE NADH kinase: all-trans- menaquinol-8 biosynthesis acetyl-CoA C- pyridoxal 5'-phosphate biosynthesis II acyl carrier methylenetetrahydrofolate 1,4-dihydroxy- -dihydrolipoyl]- oxidized trxB 1,4-dihydroxy- octaprenyl ACP synthase II: thioesterase: ketoacyl-ACP synthase dehydrogenase dehydrogenase: synthase: hexaprenyl AFER_RS05820 nonaprenyl 1,4-dihydroxy- acyltransferase: a [prokaryotic an apo-[methylmalonyl- an N-terminal- an N-terminal- an unstable L-lysine factor 420-1 2-naphthoate E2 protein] N 6 gap protein folylpolyglutamate diphosphate 2-naphthoate + diphosphate 2-naphthoate diphosphate AFER_RS05585 AFER_RS04115 III: AFER_RS05570 alpha-ketoacid cob(II)inamide ubiquitin-like protein] oxaloacetate L-methionyl-L- L-methionyl-L- Ins(2)P RecA filament- AFER_RS10875 NADP AFER_RS01350 ATP a [protein]-L-lysine CoA:pyruvate biotin ITP dGDP activation synthase: F420-1:γ- demethylmenaquinol-8 -lipoyl-L-lysine dehydrogenase threonyl-[protein] seryl-[protein] DNA complex aldehydo-D-ribose D-glyceraldehyde gln an N 10 - C-terminal L-glutamate carboxytransferase] inositol DNA an apo acyl- 1,4-dihydroxy- glutamyl NAD(P) a reduced 1,4-dihydroxy- ubiquinone/ 1,4-dihydroxy- an acetoacetyl-[acp] dihydrolipoyl subunit beta: 13-DPG octanoyl-CoA ribonucleoside- 5-phosphate 3-phosphate AFER_RS10875 formyltetrahydrofolate laurate monophosphatase: repair carrier protein 2-naphthoate NADP ligase: transhydrogenase: thioredoxin 2-naphthoate menaquinone 2-naphthoate a 3-oxotetradecanoyl-[acp] dehydrogenase: AFER_RS04255 diphosphate holo-ACP a 5,10- cob(I)yrinic acid a,c-diamide biotin/lipoate A/ type I methionyl type I methionyl AFER_RS10830 protein polyprenyltransferase: biosynthesis cofE polyprenyltransferase: biosynthesis polyprenyltransferase: lpdA acyl-CoA/acyl-ACP Pup--protein reductase methylenetetrahydrofolate AFER_RS10245 long-chain-fatty- phosphoglycerate adenosyltransferase: cobO phosphoenolpyruvate aminopeptidase: aminopeptidase: RecO: pyridoxal 5'- synthase: AFER_RS08425 methyltransferase: AFER_RS08425 3-oxotetradecanoyl- dehydrogenase: ligase: pafA B protein ligase: inositol adenosylcobalamin- oxidized AFER_RS10250 AFER_RS08425 acid--CoA ligase: [+ 2 isozymes] carboxykinase (GTP) map map phosphate acpS + [acp] an [apo BCAA kinase: AFER_RS09140 cob(I)yrinic acid a,c-diamide AFER_RS05135 monophosphatase: a stabilizedrecO a holo acyl- NAD factor 420-2 AFER_RS04345 an [apo BCAA dehydrogenase dependent: synthase: AFER_RS07040 dehydrogenase AFER_RS04385 : AFER_RS03570 carrier protein NAD(+)/ NADPH menaquinol-8 reductase: fabG 6 adenosyltransferase: biotin/lipoate A/ AFER_RS03310 AFER_RS05255 RecA filament- demethylmenaquinol-6 demethylmenaquinol-8 [+ 2 isozymes] 6 E2 protein] N -S-[2- (2E)-oct-2-enoyl-CoA N6-([prokaryotic pdxT pdxS demethylmenaquinol-9 E2 protein] N AFER_RS03715 B protein ligase: an N-terminal L- myo-inositol DNA complex NADH kinase: a (3R)-3- acyl-[acyl-carrier protein] methylpropanoyl]dihydrolipoyl- 3-phospho- ubiquitin-like protein]- an N-terminal GDP -dihydrolipoyl- AFER_RS05380 met threonyl-[protein] met AFER_RS05820 hydroxytetradecanoyl-[acp] lauroyl-CoA thioesterase pathway L-lysine D-glycerate γ-L-glutamyl)- phosphoenolpyruvate L-seryl-[protein] NADP + L-lysine adenosylcobinamide IDP PLP [protein]-L-lysine 3-hydroxyacyl- triphosphate an acyl-[acyl- 2,3- a holo-[methylmalonyl- Polyprenyl Biosynthesis ACP dehydratase (S)-3- carrier protein] diphosphoglycerate- CoA:pyruvate FabZ: fabZ acyl-ACP 2-oxo acid hydroxyoctanoyl-CoA Amino Acid Biosynthesis dependent carboxytransferase] thioesterase: dehydrogenase di-trans,poly-cis phosphoglycerate a (2E)-tetradec-2-enoyl-[acp] stearate biosynthesis AFER_RS04115 subunit E2: -undecaprenyl mutase: a [3-methylcrotonoyl- N-acetyl-muramoyl-(L- Carbohydrate Biosynthesis L-histidine biosynthesis II (bacteria and plants) a fatty acid AFER_RS03695 an [HPr]- phosphoenol (3R,5S)-3- L-lysine biosynthesis I L-arginine biosynthesis II (acetyl cycle) L-leucine biosynthesis L-proline L-homoserine phosphate biosynthesis enoyl-ACP AFER_RS10145 cob(II)alamin CoA-carboxylase]- alanyl-γ-D-glutamyl-L- a type IV prepilin RNA ATP L-histidine pyruvate biotin dITP dADP hydroxy-1- biosynthesis I biosynthesis ammonia (2E,6E)-farnesyl reductase 2-oxo acid 3-oxooctanoyl-CoA L-lysine lysyl-D-alanyl-D-alanine) IPP a palmitoyl-[acp] pyrroline-5- Calvin-Benson-Bassham cycle α PRPP 3-methyl-2- (from L-glutamate) assimilation cycle III diphosphate FabI: fabI dehydrogenase 2-phospho- RdgB/HAM1 family non- ribonucleoside- UDP- -D-glucose biosynthesis asp N-acetylglutamyl- beta-ketoacyl- acetyl-CoA C- carboxylatepyrroline-5- GDP-mannose oxobutanoate subunit E2: D-glycerate phosphoenolpyruvate- canonical purine NTP diphosphate ATP phosphate 2-isopropylmalate asp penicillin- prepilin ribonuclease carboxylate aspartate kinase: glu a myristoyl-[acp] ACP synthase II: AFER_RS04260 acyltransferase: cob(I)yrinic acid a,c-diamide -protein biotin/lipoate A/ CO biosynthesis D-glucopyranose synthase: glu di-trans,poly-cis- peptidase: pyrophosphatase: rdgB PH: rph reductase reductase: D-ribulose-1,5- 2 phosphoribosyltransferase AFER_RS00570 aspartate kinase: ammonium AFER_RS05585 AFER_RS07055 adenosyltransferase: phosphotransferase: B protein ligase: binding 6-phosphate N-acetyl- AFER_RS07915 glutamate 5- decaprenylcistransferase: a 3-oxooctadecanoyl- phosphopyruvate MazG nucleotide adenosylcobalamin- ribulose D-glucopyranose phosphoglucomutase/ regulatory subunit: (2S)-2- AFER_RS00570 acyl-CoA acetyl-CoA C- AFER_RS03715 AFER_RS05135 protein AFER_RS12435 proC bisphosphate gamma- kinase: proB beta-ketoacyl- [acp] hydratase: eno AFER_RS04510 dependent: bisphosphate 6-phosphate AFER_RS00405 L-aspartyl-4-phosphate γ uppS 2: mrdA pyrophosphohydrolase: Hyp glucose-6- phosphomannomutase isopropylmalate -L-glutamyl L-aspartyl- ACP synthase II: hydrolysis acyltransferase: cob(I)yrinic acid a,c-diamide biotin/lipoate A/ AFER_RS05255 carboxylase glutamyl- glutamine 3-oxoacyl- AFER_RS08245 a nucleoside RNA phosphate alpha/beta/alpha domain ATP 3-isopropylmalate 5-phosphate 4-phosphate AFER_RS05585 AFER_RS01350 adenosyltransferase: cobO an [HPr protein]- B protein ligase: small subunit: aspartate- phosphate synthetase: di-trans,octa-cis [acyl-carrier- a 2,3,4-saturated a cleaved type dIMP diphosphate ADP I: AFER_RS02220 phosphoribosyltransferase: phosphoenol π N-acetyl-muramoyl-(L- a peptide isomerase: pgi α-D-glucopyranose reductase: dehydratase: glutamate-5- AFER_RS10185 -undecaprenyl fatty acyl CoA N -phospho- pyruvate AFER_RS05380 AFER_RS00615 semialdehyde aspartate- a 3-oxohexadecanoyl-[acp] protein] acyl-CoA pyruvate hexanoyl-CoA γ IV prepilin F6P 1-phosphate AFER_RS08710 acetylglutamate argC leuD leuC semialdehyde diphosphate adenosylcobalamin L-histidine alanyl- -D-glutamyl- D-ala dehydrogenase: semialdehyde [+ 3 isozymes] reductase: thioesterase 1-(5-phospho- kinase: argB dehydrogenase: acyl-CoA/acyl-ACP triphosphate a [methylcrotonoyl- L-lysyl-D-alanine) phosphoribulokinase: bifunctional UTP--glucose- AFER_RS00575 2-isopropylmaleate dehydrogenase: 3-oxohexadecanoyl- fabG II: tesB D-ribulose 3-phospho- β-D-ribosyl)-ATP glu gln N-acetyl-L-glutamate AFER_RS04025 a 2,3,4-saturated pyruvate dehydrogenase: CoA carboxylase]- AFER_RS00855 phosphoglucose/ 1-phosphate N-acetyl-L-glutamate AFER_RS00575 [acp] a (3R)-3- 5-phosphate L-aspartate 4- 5-semialdehyde gln kinase: pyk biotin-N 6 -L-lysine D-glycerate uridylyltransferase bifunctional 3-isopropylmalate di-trans,octa-cis hydroxyoctadecanoyl- fatty acid AFER_RS09140 phosphomannose semialdehyde glutamine- N-acetylornithine L-glutamate-5- L-aspartate 4- reductase: fabG glutamate N- dehydratase: [acp] isomerase: GalU: galU semialdehyde semialdehyde -undecaprenyl (2E)-hexenoyl-CoA 4-hydroxy- acetyltransferase/ hydrolyzing bifunctional aminotransferase: leuD leuC glutamate a (3R)-3- α ribose 5- phosphoglycerate AFER_RS09120 β phosphate 3-hydroxyacyl- pyruvate UDP-N-acetyl- -D-muramoyl- D-ribulose-1,5- β-D-fructofuranose hydrogen a reduced ribulose- UDP-α-D-glucose 1-(5-phospho- - amino-acid carbamoyl- AFER_RS08610 homoserine synthase large hydroxyhexadecanoyl-[acp] di-trans,octa-cis- isobutanoate an unsulfurated A(H2) phosphate D-ribose 5- kinase: tetrahydrodipicolinate glutamate N- (2R,3S)-3- ACP L-alanyl-γ-D-glutamyl-L- bisphosphate cys 1-phosphate peroxide a protein factor 420 D-mannopyranose D-ribosyl)-AMP phosphate dehydrogenase: subunit: gltB undecaprenyl phosphate [sulfur carrier] XTP phosphate 3- isomerase phosphate AFER_RS04385 synthase: dapA acetyltransferase acetyltransferase/ isopropylmalate 3-hydroxyacyl- dehydratase lysyl-D-alanyl-D-alanine zinc-dependent NADPH- 6-phosphate (2S,4S)-4- synthase: epimerase: B: rpiB phosphoribosyl- ArgJ: argJ amino-acid AFER_RS09360 ACP dehydratase FabZ: fabZ RdgB/HAM1 family non- dependent transketolase: tkt carB carA 3-isopropylmalate (S)-1-pyrroline- glu ribulose class I fructose- catalase/ metalloprotease: D-xylulose rpe hypothetical PRPP biosynthesis AMP hydroxy-2,3,4,5- acetyltransferase (S)-3- acetate--CoA ligase: acs canonical purine NTP F420 13-DPG dehydrogenase: 5-carboxylate FabZ: fabZ phospho-N- SufS family AFER_RS09900 5-phosphate protein: manB cyclohydrolase: tetrahydrodipicolinate L-homoserine a (2E)-octadec- hydroxyhexanoyl-CoA acetate--CoA ligase: bisphosphate bisphosphate pyrophosphatase: rdgB peroxidase D-sedoheptulose ArgJ: argJ AFER_RS07950 acetylmuramoyl- cysteine reductase: D-ribose 5- hisI 4-hydroxy- carbamoyl phosphate L-ornithine pyrroline-5- 2-enoyl-[acp] AFER_RS08505 carboxylase aldolase: HPI: katG zinc-dependent 7-phosphate α-D-mannose a (2E)-hexadec-2-enoyl-[acp] pentapeptide- desulfurase: MazG nucleotide npdG glyceraldehyde- phosphate 1-(5-phospho-β-D-ribosyl)- tetrahydrodipicolinate N-acetyl-L-ornithine (2S)-2-isopropyl- carboxylate enoyl-ACP small subunit: AFER_RS04615 metalloprotease: transketolase: tkt sedoheptulose 1-phosphate ribose-phosphate transferase: pyrophosphohydrolase: an oxidized 3-phosphate 5-[(5-phosphoribosylamino) 3-oxosuccinate reductase: AFER_RS00615 sufS AFER_RS09730 bisphosphatase: diphosphokinase: reductase: enoyl-ACP reductase AFER_RS08245 factor 420 proC AFER_RS06420 A H O dehydrogenase: methylideneamino]imidazole- AFER_RS03315 L-threonine reductase FabI: fabI isobutanoyl-CoA diphosphate 2 a peptide glpX AFER_RS08275 3-oxohexanoyl-CoA AMP XMP gap β 4-carboxamide DHAP D-glyceraldehyde dTDP- -L-rhamnose PRPP (S)-2,3,4,5- biosynthesis FabI: fabI 3-phospho- a sulfurated D-sedoheptulose pro a stearoyl-[acp] acetyl-CoA C- undecaprenyl-diphospho-N- UMP 2-phosphoglycolate ala D-glyceraldehyde GDP-α-D-mannose biosynthesis tetrahydrodipicolinate 4-methyl-2- D-glycerate [sulfur carrier] F6P 1,7-bisphosphate ornithine a palmitoyl-[acp] acetyltransferase: acetylmuramoyl-L-alanyl-γ-D- 3-phosphate α 2,3,4,5- oxopentanoate L-homoserine -D-glucopyranose carbamoyltransferase: acyl-ACP AFER_RS00545 glutamyl-L-lysyl- D-alanyl-D-alanine class I fructose- tetrahydropyridine- AFER_RS08605 hypothetical class II fructose- 1-phosphate phosphoribulosylformimino- branched-chain superpathway of L-serine acyl-ACP thioesterase: bisphosphate glucose-1-phosphate 2,6-dicarboxylate N- protein: [+ 2 isozymes] bisphosphatase: triose-phosphate AICAR-phosphate amino acid and glycine biosynthesis I thioesterase: AFER_RS04115 UDP-N-acetyl-α-D- a 1-acyl-2- a [lipoyl-carrier aldolase: thymidylyltransferase: succinyltransferase: L-tryptophan biosynthesis AFER_RS03340 di-trans,octa-cis- an acyl-[acyl- glpX isomerase: transaminase: O-phospho- AFER_RS04115 butanoyl-CoA γ arachidonoyl- D-threo-isocitrate 6 AFER_RS04615 AFER_RS03770 AFER_RS12270 3-phospho- muramoyl-L-alanyl- -D- ATP protein]-N -[(R) met AFER_RS04390 α AFER_RS07955 L-homoserine stearate undecaprenyl phosphate carrier protein] a tRNA precursor ITP GTP dTDP- -D-glucose imidazole D-glycerate glutamyl-L-lysyl-D-alanine sn-glycerol NADP-dependent -dihydrolipoyl]- N-succinyl-2-amino- phosphoglycerate palmitate acyl-CoA/acyl-ACP CTP RdgB/HAM1 family non- bifunctional β-D-fructose 1,6- glycerol gln threonine long-chain-fatty- 3-phosphate CTP isocitrate L-lysine dihydrolipoyl diguanylate dTDP-glucose 4,6- 6-ketopimelate chorismate leu dehydrogenase: dehydrogenase: canonical purine NTP glutamate N- DHAP phosphate synthase: long-chain-fatty- acid--CoA ligase: phospho-N- phosphate dehydrogenase: dehydrogenase: cyclase: bisphosphate dehydratase: rfbB L-citrulline AFER_RS07920 AFER_RS09140 pyrophosphatase: rdgB acetyltransferase/ synthase: AFER_RS09355 CCA tRNA AFER_RS10270 AFER_RS01520 AFER_RS01150 dTDP-4-dehydro-6- 3-phosphooxypyruvate acid--CoA ligase: AFER_RS07040 acetylmuramoyl- acyltransferase phosphatidate amino-acid hisF hisH anthranilate nucleotidyltransferase: MazG nucleotide a [lipoyl-carrier deoxy-α-D-glucopyranose argininosuccinate threonine AFER_RS07040 [+ 2 isozymes] crotonyl-CoA pentapeptide- PlsX: plsX cytidylyltransferase: NADP-dependent [+ 2 isozymes] acetyltransferase [+ 2 isozymes] synthase: AFER_RS00110 pyrophosphohydrolase: protein]-N 6 -[(R c-di-GMP N-succinyl-L,L-2,6- synthase: phosphoserine synthase: [+ 2 isozymes] transferase: AFER_RS11525 isocitrate ArgJ: argJ D-erythro-1- AFER_RS05650 stearoyl-CoA dehydrogenase: icd AFER_RS08245 )-lipoyl]-L-lysine N-acetyl-L- fructose- AICAR diaminopimelate AFER_RS08595 transaminase: AFER_RS09545 AFER_RS06420 (imidazol-4- palmitoyl-CoA a tRNA IMP methionine bisphosphate succinyl- AFER_RS07930 acyl-carrier protein an acyl phosphate a CDP-1-acyl- 2-oxoglutarate dTDP-4-dehydro- yl)-glycerol thr aldolase class I: L-arginino-succinate anthranilate PRPP (S)-3- undecaprenyl-diphospho-N containing a 2-arachidonoyl- β-L-rhamnose 3-phosphate diaminopimelate O-phospho- UMP AFER_RS00905 L-valine biosynthesis hydroxybutanoyl-CoA -acetylmuramoyl-L-alanyl-γ- 3' CCA end glycerol dTDP-4- imidazoleglycerol- desuccinylase: argininosuccinate L-serine class I fructose- D-glutamyl-L-lysyl- D-alanine dehydrorhamnose phosphate dapE lyase: argH anthranilate bisphosphate reductase: rfbD dehydratase phosphoribosyltransferase: trpD pyruvate aldolase: L,L-diaminopimelate a 2'- β HisB: hisB arg acetolactate ARP acetoacetate an alkylated DNA DNA with lesion N-ethylglycine an unfolded AFER_RS04615 dTDP- -L-rhamnose 3-(imidazol-4- acetoacetyl-CoA tyr SAM deoxyribonucleoside a tRNA precursor big endothelin synthase [DNA] protein yl)-2-oxopropyl diaminopimelate N-(5-phosphoribosyl)-anthranilate ser 5'-triphosphate excinuclease large subunit: Secondary Metabolite Biosynthesis acetyl-CoA C- chaperonin phosphate epimerase: dapF AFER_RS08300 L-cysteine ABC: uvrA uvrC GroEL: groL phosphoribosylanthranilate serine acyltransferase: acetoacetate- DNA-3- glycine histidinol- biosynthesis I 5-amino-6-(D-ribitylamino) excinuclease isomerase: AFER_RS05615 acetolactate AFER_RS07055 -CoA ligase: DNA-directed methyladenine ribonuclease D: peptidase M13: oxidase chaperonin phosphate hydroxymethyltransferase: streptorubin B biosynthesis ABC subunit meso-diaminopimelate synthase: ilvN methylerythritol phosphate pathway I uracil--L-tyrosine AFER_RS05885 DNA polymerase: ThiO: thiO GroEL: groL glycine biosynthesis II 1-(2-carboxyphenylamino)-1- AFER_RS09320 [+ 2 isozymes] glycosylase: AFER_RS08370 AFER_RS04185 UvrB: uvrB transaminase: AFER_RS08020 ser 4-hydroxyphenyl AFER_RS08355 deoxy-D-ribulose 5-phosphate AFER_RS08585 DNA without a protein hisC a [glycine-cleavage serine O- acetyl-CoA acetyl-CoA transferase CofH: cofH [+ 5 isozymes] diaminopimelate (S)-2-acetolactate gly D-glyceraldehyde pyruvate lesion L-histidinol complex H protein] N 6 - indole-3-glycerol- acetyltransferase: decarboxylase: lysA ketoacyl-ACP 3-phosphate acetoacetyl-CoA diphosphate a DNA containing a nucleoside 5'- ethylamine glyoxylate phosphate aminomethyldihydrolipoyl- phosphate synthase: ketol-acid cysE AMP an alkylated a tRNA endothelin 1 a peptide synthase III: 5-amino-5-(4-hydroxybenzyl)-6- an apurinic/ monophosphate L-lysine AFER_RS05620 reductoisomerase: O-acetyl-L-serine 5'-deoxyadenosine 2-iminoacetate [DNA] nucleobase histidinol- lys AFER_RS05570 1-deoxy-D- (D-ribitylimino)-5,6-dihydrouracil met apyrimidinic site glycine cleavage ilvC xylulose-5- peptidoglycan biosynthesis I Cell Structure Biosynthesis phosphatase: glycine cleavage gly (1S,2R)-1-C-(indol-3- (2R)-2,3- fatty acid β-oxidation I (generic) system protein cysteine phosphate (meso-diaminopimelate containing) AFER_RS01810 system protein yl)glycerol 3-phosphate dihydroxy-3- alanine an acetoacetyl-[acp] GcvH: gcvH synthase A: cysK synthase: GcvH: gcvH methylbutanoate racemization a 2'- a peptide with a [protein] N- 4-(2'- UDP-N-acetyl- histidinol [+ 6 isozymes] tryptophan AFER_RS02455 a (3Z)-alk-3-enoyl-CoA [+ 4 isozymes] 3-oxoacyl- pyruvate a cytidine 34 [DNA] α-D-glucosamine synthase: trpA trpB dihydroxy-acid DL-allothreonine deoxyribonucleoside [DNA] an N-terminal terminal-formyl- lys carboxyphenyl)- repressor LexA a [glycine-cleavage a [glycine-cleavage cys Ile2 UDP-N-acetylglucosamine histidinol dehydratase: ala [acyl-carrier- 5'-triphosphate Xaa-L-proline L-methionine in tRNA 4-oxobutyryl-CoA DNA complex H protein] N 6 complex H protein] N 6 1-deoxy-D-xylulose 1,4-dihydroxy- 1-carboxyvinyltransferase: dehydrogenase: L-alanine indole ser ilvD alanine protein] polymerase -dihydrolipoyl-L-lysine -[(R)-lipoyl]-L-lysine 5-phosphate 2-naphthoyl- repressor racemase: reductase: pyruvate, III subunit murA hisD biosynthesis III 3-methyl-2- L-glutamate serine DNA-directed leucyl peptide tRNA lysidine(34) CoA synthase: LexA: lexA AFER_RS06380 fabG 1-deoxy-D-xylulose- phosphate gamma/ UDP-N-acetyl-α- tryptophan oxobutanoate biosynthesis III a (2E)-2-enoyl-CoA hydroxymethyltransferase: DNA polymerase: aminopeptidase: deformylase: synthetase TilS: AFER_RS01320 histidinal a (3R)-3- 5-phosphate dikinase: 1,4-dihydroxy-2- tau: dnaX cleaved D-glucosamine- cys branched-chain alanine a 2,3,4-saturated long-chain-fatty- AFER_RS09320 AFER_RS08355 AFER_RS03725 def AFER_RS11330 synthase: trpA trpB hydroxybutanoyl- reductoisomerase: AFER_RS06500 a 2'- repressor LexA enolpyruvate histidinol amino acid racemase: alr 2-oxoglutarate fatty acid acyl-CoA/acyl-ACP [+ 5 isozymes] naphthoyl-CoA SufS family [acp] AFER_RS03245 acid--CoA ligase: a 2,3,4-saturated (3R deoxyribonucleoside glycine cleavage D-ala glutamate dehydrogenase: UDP-N- dehydrogenase: cysteine transaminase: AFER_RS04120 )-3-hydroxyacyl-CoA a peptide with 34 5'-monophosphate 3-hydroxyacyl- a proteinogenic an N-terminal L- a lysidine system protein trp synthase large AFER_RS09140 phosphoenol + acetaldehyde formate acetylmuramate hisD desulfurase: AFER_RS07955 ACP MEP [+ 2 isozymes] a 2,3,4-saturated a 2,3,4-saturated (3S diphosphate H gly an N-terminal methionyl-[protein] in tRNA Ile2 GcvH: gcvH subunit: gltB AMP pyruvate [DNA] amino acid dehydrogenase: sufS dehydratase fatty acyl CoA )-3-hydroxyacyl-CoA L-proline murB his [+ 7 isozymes] ala val glu FabZ: fabZ 2-C-methyl-D- acetyl-CoA C- ala UDP-N-acetyl- erythritol 4-phosphate acyltransferase: α a (2E)-but- -D-muramate cytidylyltransferase: AFER_RS01350 4 2-enoyl-[acp] a [2-oxoglutarate- an O - an all-trans- a supercoiled ispF coenzyme A a sulfurated a [protein]- a peptide with a a 2,3,4-saturatedacetyl-CoA C-a 2,3,4-saturated SAM dehydrogenase methylthymine 1,4-dihydroxy- polyisoprenyl asp O-ureido-L- sarcosine ile duplex DNA a protein UDP-N- glu enoyl-ACP 4-(cytidine 5'- [sulfur carrier] L-cysteine leader sequence fatty acyl CoAacyltransferase:3-oxoacyl-CoA E2 protein] N 6 - in DNA 2-naphthoate diphosphate homoserine replicative acetylmuramate- reductase diphospho)-2-C- branched-chain AFER_RS07055 octanoyl-L-lysine DNA -L-alanine glutamate FabI: fabI methyl-D-erythritol amino acid proteasome methylated-DNA-- 1,4-dihydroxy- signal argininosuccinate helicase: ATPase: arc ligase: murC racemase: glycine oxidase transaminase: lipoyl [protein]-cysteine S- 2-naphthoate peptidase synthase: dnaB AFER_RS09055 a butanoyl-[acp] ThiO: thiO AFER_RS07955 UDP-N-acetyl- synthase: methyltransferase: polyprenyltransferase: I: lepB AFER_RS08595 (3S)-3-methyl-2- [+ 3 isozymes] an unfolded Nucleoside and Nucleotide Biosynthesis 2-phospho-4-(cytidine lipA AFER_RS01480 oxopentanoate a single protein α-D-muramoyl- D-glt beta-ketoacyl- acetyl-CoA AFER_RS08425 5'-diphospho)-2-C- stranded DNA thiol RS02665 thiol L-alanine ACP synthase II: a [2-oxoglutarate glyoxylate methylamine superpathway of purine nucleotides de novo biosynthesis I AFER_RS05585 methyl-D-erythritol 5'-deoxyadenosine an unsulfurated a [protein]-S- canavaninosuccinate superpathway of met dehydrogenase a thymine in DNA a leader sequence a peptide UDP-N- ppGpp metabolism Metabolic Regulator Biosynthesis CMP superpathway of pyrimidine 2-C-methyl-D- [sulfur carrier] methyl-L-cysteine DMKH trehalose biosynthesis I a 3-oxohexanoyl- E2 protein] N 6 2 acetylmuramoyl- phosphorylation adenosine nucleotides nucleobases salvage erythritol 2,4- fluoride RS02340 fluoride PRPP de novo biosynthesis I [acp] cyclodiphosphate -lipoyl-L-lysine L-alanine-- pppGpp CMP uracil D-glucopyranose synthase: ispF D-glutamate UDP-α-D-glucose (d)CMP kinase: bifunctional pyr operon 3-oxotehexanoyl- 6-phosphate 6 ligase: murD bifunctional (p)ppGpp amidophosphoribosyltransferase: purF IMP [acyl-carrier adenine 2503 an O - all-trans- a [protein]-L- succinate AFER_RS06960 asp transcriptional regulator/uracil 2-C-methyl-D-erythritol- a [protein]- an N-modified a [protein] Ser/Thr synthetase/guanosine- protein] methylguanine dodecaprenyl 1,4-dihydroxy- Ins(1)P ω a protein an anion RS01230 an anion guanosine 3'- CDP phosphoribosyltransferase 2,4-cyclodiphosphate in 23S rRNA L-cysteine aminoacyl-[tRNA] proline ( = 180) semialdehyde trehalose-6- 5-phospho-β- Inorganic in DNA 2-naphthoate serine/threonine peptidylprolyl NAD-dependent UDP-N-acetyl- 3',5'-bis(diphosphate) 3'- diphosphate 5'- trehalose biosynthesis II gly PyrR: pyrR reductase: fabG diphosphate inositol meso- phosphate D-ribosylamine nucleoside- flavodoxin- Nutrient protein kinase: isomerase: α-D-muramoyl-L- pyrophosphohydrolase: triphosphate 3'- adenylosuccinate UMP a (3R)-3- monophosphatase: succinate- proteasome: diaminopimelate synthase: diphosphate dependent 23S rRNA AFER_RS04490 alanyl-D-glutamate AFER_RS04875 diphosphatase: D-glucopyranose synthase: hydroxyhexanoyl- Metabolism methylated-DNA-- aminoacyl-tRNA AFER_RS10830 AFER_RS00555 semialdehyde AFER_RS09550 ADP-α-D-glucose kinase: ndk UMP kinase: (E)-4-hydroxy- (adenine(2503)-C(2) 1,4-dihydroxy- prcB prcA potassium- AFER_RS04875 6-phosphate phosphoribosylamine- AFER_RS10140 [acp] urea cycle [protein]-cysteine S- hydrolase: serine/threonine- [+ 3 isozymes] dehydrogenase: AFER_RS03225 3-methylbut- )-methyltransferase 2-naphthoate inositol a [protein]-L- K + transporting K + Mur ligase -glycine ligase: purD CTP 3-hydroxyacyl- methyltransferase: AFER_RS08265 protein kinase: AFER_RS06185 α,α-trehalose 2-enyl- RlmN: rlmN polyprenyltransferase: monophosphatase: proline (ω = 0) a peptide ATPase middle domain- trehalose-6- UDP ACP AFER_RS01480 AFER_RS08050 succinate 6-phosphate adenylo-succinate diphosphate AFER_RS08425 AFER_RS03310 containing phosphate dehydratase arg a [protein] (L-serine/L- GTP ppGpp GAR nucleoside- synthase: ispG myo-inositol protein: trehalose-6- FabZ: fabZ a 2-methyladenine 2503 an N-modified an uncharged threonine) phosphate synthase: adenylosuccinate diphosphate kinase: ndk 5'-deoxyadenosine a [protein]-S- phosphate (E)-4-hydroxy-3- met a guanine in DNA tRNA AFER_RS03055 AFER_RS09550 trehalose phosphoribosylglycinamide lyase: a (2E)-hex- ammonium in 23S rRNA methyl-L-cysteine DMK-12 amino acid D-ala UTP methylbut-2-en- [+ 2 isozymes] nucleoside- phosphatase: formyltransferase: argininosuccinate biosynthesis IV AFER_RS10130 2-enoyl-[acp] 1-yl diphosphate peptidoglycan maturation (meso-diaminopimelate containing) diphosphate GDP AFER_RS09555 α,α-trehalose AFER_RS01655 CTP synthase: lyase: argH glutamine- UDP-N-acetyl- hypothetical bifunctional (p)ppGpp α guanine and guanosine salvage enoyl-ACP kinase: ndk pyrophosphokinase: α α 6-phosphate -maltose AFER_RS05810 hydrolyzing all-trans- 6 65 , -trehalose FGAR AMP reductase 5-methoxy-6- a [protein]- a DNA methyl a [histone]-N - 2+ a uridine α-D-muramoyl- protein: lipid II (meso AFER_RS04875 synthetase/guanosine- maltose alpha-D- 4-hydroxy- NaMN 1,4-dihydroxy- adenosylcobinamide Mg protoporphyrin IX DMKH histidinol trehalose-6- CTP carbamoyl- methylbenzimidazole L-cysteine phosphotriester tridecaprenyl acetyl-L-lysine in tRNA 2 L-alanyl-γ-D- AFER_RS03060 diaminopimelate containing) 3',5'-bis(diphosphate) 3'- glucosyltransferase: FabI: fabI L-arginino- 2-naphthoate phosphate phosphoribosylformylglycinamidine 3-methylbut- L-ornithine phosphate diphosphate bifunctional tRNA ubiquinone/ histidinol glutamyl-meso-2,6- pyrophosphohydrolase: treS guanosine succinate D-alanyl-D-alanine phosphatase: synthase: purL purQ purS adenylate kinase: a hexanoyl-[acp] 2-enyl synthase: adenosylcobinamide pseudouridine menaquinone dehydrogenase: diaminopimelate AFER_RS04875 α,α-trehalose 4-hydroxy- nicotinate-nucleotide-- methylated-DNA-- histone magnesium AFER_RS09555 AFER_RS02165 diphosphate carB carA 1,4-dihydroxy- kinase/ synthase: biosynthesis hisD GDP 3-methylbut- reductase: dimethylbenzimidazole [protein]-cysteine S- deacetylase: chelatase: a nascent peptidoglycan FGAM beta-ketoacyl- carbamoyl 2-naphthoate adenosylcobinamide- AFER_RS10750 methyltransferase: D-alanyl-D- α,α-trehalose pyrimidine deoxyribonucleotide 2-enyl ispH phosphoribosyltransferase: methyltransferase: AFER_RS00115 AFER_RS01605 a pseudouridine 65 with (L-alanyl-γ-D-glutamyl- ACP synthase II: phosphate polyprenyltransferase: phosphate AFER_RS04345 his alanine-adding guanine ADP phosphorylation diphosphate argininosuccinate ornithine cobT AFER_RS01480 in tRNA meso-2,6-diaminopimeloyl-D- phosphoribosylformylglycinamidine AFER_RS05585 AFER_RS08425 guanylyltransferase: MQH enzyme: cyclo-ligase: AFER_RS10065 reductase: synthase: carbamoyltransferase: AFER_RS02735 Mg- 2 alanyl-D-alanine) pentapeptide dTMP dCMP acetate a [histone]-L-lysine AFER_RS09380 ribonucleoside- a 3-oxooctanoyl- ispH IPP AFER_RS08595 AFER_RS08605 5-methoxy-6- hypoxanthine dTMP (d)CMP kinase: a [protein]-S- adenosyl-cobinamide protoporphyrin AIR diphosphate [acp] L-citrulline methylbenzimidazole nicotinate [DNA] penicillin-binding penicillin-binding phosphoribosyltransferase: hpt kinase: tmk AFER_RS06960 methyl-L-cysteine DMKH2-13 phosphate UDP-N-acetyl- reductase 3-oxooctanoyl- sulfur ribotide phosphate α protein 2: mrdA protein 2: dTDP dCDP -D-muramoyl- 5-(carboxyamino) adenosylcobalamin- [acyl-carrier reduction II (via γ AFER_RS00440 a mature peptidoglycan with L-alanyl- -D- a nascent peptidoglycan γ imidazole GMP dependent: nucleoside- nucleoside- protein] polysulfide) [+ 2 isozymes] (L-alanyl- -D-glutamyl-meso- 13 glutamyl-meso-2,6- di-trans,octa-cis with (L-alanyl-γ-D-glutamyl- ribonucleotide AFER_RS05255 diphosphate diphosphate a uridine a [protein]- 2,6-diaminopimeloyl-D-alanyl- reductase: 0 5-methoxybenzimidazole NaMN 2-oxoglutarate 1,4-dihydroxy- GGPP coenzyme A canavaninosuccinate (3S)-citryl-CoA diaminopimeloyl- mutase: purE kinase: ndk kinase: ndk DMAPP polyphosphate metabolism S VibB in tRNA L-histidine his -undecaprenyl meso-2,6-diaminopimeloyl- a nascent peptidoglycan D-alanine) pentapeptide fabG 2-naphthoate D-alanyl-D-alanine multifunctional oxoglutarate tRNA two-component phosphate D-alanine) tetrapeptide with D,D cross-links (meso- asp dADP dTTP dCTP a (3R)-3- histidine CAIR long chain decarboxylase/oxoglutarate pseudouridine sensor histidine diaminopimelate containing) hydroxyoctanoyl- nicotinate-nucleotide-- dehydrogenase thiamine 1,4-dihydroxy- holo-ACP argininosuccinate citryl-CoA lyase: synthase: kinase: ammonia- phospho-N- L,D-transpeptidase: L,D-transpeptidase: polyphosphate glyphosate a polysulfide nucleoside- [acp] dimethylbenzimidazole pyrophosphate-binding 2-naphthoate synthase: lyase: argH AFER_RS10480 AFER_RS10750 AFER_RS01025 lyase: hutH acetylmuramoyl- AFER_RS10910 AFER_RS10910 phosphoribosylaminoimidazolesuccinocarboxamide degradation II 13 a [protein]- diphosphate 3-hydroxyacyl- polysulfide phosphoribosyltransferase: subunit/dihydrolipoyllysine- polyprenyltransferase: acpS a pseudouridine urocanate pentapeptide- a nascent peptidoglycan with a mature peptidoglycan synthase: AFER_RS10125 kinase: ndk ACP cobT in tRNA N-phospho- a nascent peptidoglycan a nascent peptidoglycan a mature peptidoglycan myo-inositol reductase residue succinyltransferase AFER_RS08425 transferase: (L-alanyl-γ-D-glutamyl-meso- with (L-alanyl-γ-D-glutamyl- dehydratase polyphosphate exopolyphosphatase: glyphosate L-histidine with L,D cross links (meso- with (L-alanyl-γ-D-glutamyl- with D,D cross-links (meso- biosynthesis NrfD: nrfD subunit: AFER_RS08950 L-canavanine fumarate acetyl-CoA oxaloacetate AFER_RS06420 2,6-diaminopimelate) tripeptide meso-2,6-diaminopimeloyl- FabZ: fabZ kinase 1: ppk1 AFER_RS05155 3',5'-ADP a holo-[VibB aryl- diaminopimelate containing) SAICAR dATP diaminopimelate containing) meso-2,6-diaminopimeloyl- D-alanine) tetrapeptide D-glucopyranose 5-methoxybenzimidazole nicotinate succinate semialdehyde carrier protein] a (2E)-oct- glycine a polysulfide demethylmenaquinol-4 undecaprenyldiphospho- glycine) tetrapeptide 6-phosphate ribotide phosphate adenylosuccinate 2-enoyl-[acp] inositol-3- oxidase N-acetylmuramoyl-L- superpathway of guanosine long chain a mature peptidoglycan with lyase: phosphate ThiO: thiO alanyl-γ-D-glutamyl-meso nucleotides de novo biosynthesis I enoyl-ACP polyphosphate a mature peptidoglycan (L-alanyl-γ-D-glutamyl-meso- AFER_RS10130 -2,6-diaminopimeloyl- synthase: (1S,2R)-1- guanosine 2251 a uridine 32 β-D-glucose with L,D cross-links (meso- a mature peptidoglycan reductase 5-hydroxybenzimidazole NaMN a proteinogenic leukotriene-C4 a ribonucleoside protoheme 2,6-diaminopimelate) tripeptide AFER_RS00185 (aminomethyl) ser C-(indol-3- 6-phosphate gly D-alanyl-D-alanine diaminopimelate containing) with (L-alanyl-γ-D-glutamyl- AICAR IMP FabI: fabI glyoxylate amino acid diphosphate in 23S rRNA in tRNA pyrimidine deoxyribonucleotides de novo biosynthesis III Ins(3)P phosphonate yl)glycerol ribonucleoside- 23S rRNA tRNA inositol-3- UDP-N- meso-2,6-diaminopimeloyl- glycine bifunctional an octanoyl-[acp] 3-phosphate diphosphate (guanosine(2251) pseudouridine phosphate acetylglucosamine- glycine) tetrapeptide nicotinate-nucleotide-- oxidase phosphoribosylaminoimidazolecarboxamide inosine 5'- UDP CTP inositol gamma- reductase -2'-O)- ferrochelatase: synthase: synthase: -N-acetylmuramyl- dimethylbenzimidazole tryptophan ThiO: thiO formyltransferase/IMP cyclohydrolase: purH monophosphate ribonucleoside- beta-ketoacyl- monophosphatase: glutamyltransferase: adenosylcobalamin- methyltransferase AFER_RS07855 AFER_RS10750 AFER_RS00185 (pentapeptide) phosphoribosyltransferase: synthase: a pseudouridine 32 Aromatic Compound Biosynthesis dehydrogenase: diphosphate reductase ACP synthase II: AFER_RS10830 dependent: RlmB: rlmB glyoxylate pyrophosphoryl- CDP cobT AFER_RS03590 2-O- Ins(3)P FAICAR AFER_RS02360 adenosylcobalamin- AFER_RS05585 trpA trpB in tRNA inositol AFER_RS05255 methylguanosine 2251 undecaprenol N- dependent: a 2'- chorismate biosynthesis I ribonucleoside- monophosphatase: Fe 2+ protoporphyrin IX acetylglucosamine dipicolinate biosynthesis bifunctional a 3-oxodecanoyl- an α-(γ-L-glutamyl) D-glyceraldehyde deoxyribonucleoside in 23S rRNA XMP AFER_RS05255 diphosphate reductase leukotriene-D4 transferase: phosphoribosylaminoimidazolecarboxamide [acp] AFER_RS03310 5-hydroxybenzimidazole nicotinate trp 5'-diphosphate D-erythrose dUDP adenosylcobalamin- Amino Acid Degradation -L-amino acid 3-phosphate AFER_RS11060 formyltransferase/IMP cyclohydrolase: purH ribotide phosphate 4-phosphate glutamine- 3-oxodecanoyl- myo-inositol asp nucleoside- dependent: lipid II (meso 3-deoxy-7- [acyl-carrier hydrolyzing GMP diphosphate kinase: ndk AFER_RS05255 L-glutamate diaminopimelate phosphoheptulonate aspartate kinase: IMP protein] L-methionine degradation synthase: guaA degradation VI L-arginine a peptidoglycan a [release factor]- an [amino-group carrier GDP-α-D- containing) synthase class II: AFER_RS00570 dUTP dCDP reductase: I (to L-homocysteine) 3-methylbutanoate a proteinogenic glutathione succinate γ roseoflavin (to pyruvate) degradation dimer (generic) L-glutamine protein]-C-terminal- - mannose D-ala AFER_RS04080 L-aspartyl- amino acid 3-deoxy- GMP dUTP diphosphatase: dut nucleoside- fabG III (arginine peptide chain (L-glutamyl)-L-glutamate GDP-mannose bifunctional D-arabino- 4-phosphate diphosphate kinase: ndk a (3R)-3- met 4,6-dehydratase: riboflavin kinase/ glycine inosine 5'- MazG nucleotide glu decarboxylase/ endolytic release factor acetylglutamate heptulosonate hydroxydecanoyl- methionine acetate--CoA ligase: acs ADP-forming AFER_RS03795 FAD synthetase: oxidase aspartate- monophosphate pyrophosphohydrolase: dCTP agmatinase pathway) gamma- transglycosylase N(5)-glutamine kinase: argB 7-phosphate [acp] adenosyltransferase: arg acetate--CoA ligase: succinate--CoA [+ 2 isozymes] AFER_RS03295 ThiO: thiO semialdehyde dehydrogenase: AFER_RS08245 glutamyltransferase: MltG: mltG methyltransferase: an [amino-group carrier 3-dehydroquinate 3-hydroxyacyl- AFER_RS08765 AFER_RS08505 ligase: sucC sucD GDP-4-dehydro- roseoflavin dehydrogenase: AFER_RS02360 AFER_RS03590 prmC protein]-C-terminal- pyruvate synthase: dUMP ACP SAM a [release factor]-N 5 α-D-rhamnose 5'-phosphate AFER_RS00575 γ-(5-phospho-L- AFER_RS08885 dehydratase GlcNAc-1,6- GDP FAD-dependent (2S, 3S)-3- agmatine a lipid II -methyl-L-glutamine L-aspartate 4- FabZ: fabZ 3-methylbutanoyl-CoA an α-(γ-L-glutamyl) phosphate succinyl-CoA anhydro-MurNAc- glutamyl)-L-glutamate thymidylate synthase: methylaspartate AMP diphosphate L-cysteinylglycine ADP 3-dehydroquinate semialdehyde -L-amino acid pentapeptide XMP AFER_RS04735 a (2E)-dec- agmatinase: 4-hydroxy- type II 3- nucleoside- ribonucleoside- dTMP 2-enoyl-[acp] speB dehydroquinate tetrahydrodipicolinate glutamine- diphosphate diphosphate enoyl-ACP SAH dehydratase: aroQ synthase: dapA hydrolyzing dTMP kinase: tmk putrescine a nascent peptidoglycan an N-formyl-L- 4-fumaryl- a 3,5,7,9,11,13,15- kinase: ndk reductase reductase mesaconate a 3- a monocarboxylic acryloyl-CoA orotidine 5'- (2S,4S)-4- GMP asp (meso-DAP containing) hypoglycin A glutathione methionylaminoacyl- hepta-oxo- adenosylcobalamin- FabI: fabI adenosylhomocysteinase: acetoacetate demethyubiquinol acid amide phosphate 3-dehydroshikimate hydroxy-2,3,4,5- ubiquinone/ synthase: dTDP AFER_RS09115 tRNA hexadecanoyl-[PKS-acp]aldo/keto amidase: crotonyl-CoA tetrahydrodipicolinate adenylosuccinate dependent: orotidine-5'- guaA a decanoyl-[acyl- endolytic reductase: menaquinone AFER_RS01195 carboxylase/ shikimate synthase: GTP AFER_RS05255 nucleoside- fumarylacetoacetate phosphate carrier protein] transglycosylase gamma- peptide AFER_RS01375 biosynthesis [+ 2 isozymes] reductase: dehydrogenase: AFER_RS10140 diphosphate kinase: ndk L-homocysteine L-glutamine (FAA) hydrolase: decarboxylase: GMP beta-ketoacyl- (S)-citramalate MltG: mltG glutamyltransferase: deformylase: [+ 3 isozymes] methyltransferase: ccrA aroE dTTP degradation I AFER_RS06080 9-hydroxy-3,5,7,11,13,15- a monocarboxylate (R)-methylmalonyl- pyrF AFER_RS03590 def AFER_RS04345 UMP dipicolinate adenylo-succinate dGDP ACP synthase II: hexaoxohexadecanoyl- CoA shikimate AFER_RS05585 a mature peptidoglycan a nascent peptidoglycan [PKS-acp] UQH a 3- citramalate gln 2 adenylosuccinate pro with (L-alanyl-γ-D-glutamyl- (meso-DAP containing) acetoacetate fumarate hypothetical nucleoside- oxododecanoyl- synthase: imidazole hypoglycin B L-cysteinylglycine formate a L-methionylaminoacyl- lyase: L-glutamate meso-2,6-diaminopimeloyl- with GlcNAc terminus protein: diphosphate [acp] AFER_RS07960 glycerol tRNA AFER_RS10130 degradation IX (via D-alanine) tetrapeptide AFER_RS01155 kinase: ndk guanine and guanosine salvage II 3-oxododecanoyl- phosphate GDP 4-aminobutanoate) shikimate 3- [acyl-carrier pyruvate synthase: AMP acetate phosphate dGTP protein] an L-prolyl- hisF hisH RNase III mRNA a cytidine 1402 adenosyl-cob(III) glu a 5-L-glutamyl- hydrogen selenide acetyl-CoA DMK-12 crotonyl-CoA prephenate [+ 6 isozymes] an amino acid O-acetyl-L-serine processing in 16S rRNA yrinate a,c-diamide 3-phosphoshikimate 1- guanosine reductase: fabG [RedO prolyl- glutamate [peptide] a (3R)-3- substrate acetyl-CoA carboxylase 16S rRNA ubiquinone/ crotonyl-CoA carboxyvinyltransferase: adenylate kinase: carrier protein] glu cobyric acid prephenate decarboxylase: biotin carboxylase (cytidine(1402)-2'-O) menaquinone carboxylase/ ribonucleoside- AFER_RS02165 hydroxydodecanoyl- synthase: dehydratase: aroA AFER_RS08500 cysteine subunit: AFER_RS03755 5-enolpyruvoyl- diphosphate [acp] L-glutamine gamma- hypothetical -methyltransferase: biosynthesis AFER_RS04205 reductase: pheA 4-aminobutanoate synthase 3-hydroxyacyl- degradation II glutamyltransferase: acetyl-CoA carboxylase rsmI methyltransferase: ccrA shikimate 3- reductase adenine salvage guanine a 1H-pyrrole- protein: a 2'-O- 3-phenyl-2- nucleoside- ADP ACP A: cysK AFER_RS04345 adenosylcobyrate (2S)- phosphate adenosylcobalamin- AFER_RS03590 AFER_RS07805 carboxyltransferase methylcytidine 1402 oxopropanoate diphosphate dehydratase 2-carbonyl- ethylmalonyl-CoA chorismate dependent: gln L-glutamate subunit: AFER_RS05285 in 16S rRNA menaquinol-12 kinase: ndk hypoxanthine FabZ: fabZ [RedO prolyl- synthase: AFER_RS05255 ribonucleoside- glutamate degradation I an α-(5-L- acetate RNase III malonyl-CoA adenine phosphoribosyltransferase: hpt carrier protein] L-selenocysteine aroC diphosphate a (2E)-dodec- synthase large L-alanine glutamyl)- a peptide an mRNA fragment processing degradation IV reductase 2-enoyl-[acp] malonyl-CoA subunit: gltB glu amino acid product mRNA chorismate adenosylcobalamin- GMP glu enoyl-ACP NAD-glutamate dependent: adenine deaminase: ade a [RedX acyl- reductase ala dehydrogenase: dGDP AFER_RS05255 adenine and carrier protein]- an L-methionyl- an N 10 - (S)-5-amino-3- a cytidine 1402 FabI: fabI alanine AFER_RS10715 coenzyme A an apo [peptidyl- acetyl-CoA 7,8-dihydroneopterin DMKH2-13 5-aminolevulinate N5-CAIR NADH Met oxohexanoate adenosine (1H-pyrrole- [initiator tRNA ] formyltetrahydrofolate carrier protein] 2',3'-cyclic phosphate in 16S rRNA GTP dehydrogenase: ald 2-oxoglutarate 16S rRNA ubiquinone/ 5-(carboxyamino) dADP hypoxanthine AMP salvage VI 2-carbonyl) polyprenol NAD(+)/ a dodecanoyl-[acp] a malonyl-[RedN] pyruvate (cytosine(1402)-N(4) menaquinone porphobilinogen imidazole nucleoside- malonyl-CoA -L-cysteine 3-keto-5- phosphomannose- NADH kinase: methionyl-tRNA holo-ACP dependent alpha 1,6 )-methyltransferase biosynthesis synthase: hemB ribonucleotide diphosphate nucleoside- adenosine aminohexanoate AFER_RS05820 hypoxanthine Nucleoside and formyltransferase: synthase: mannosyltransferase 4 RsmH: rsmH methyltransferase: mutase: purE kinase: ndk diphosphate cleavage protein: an N - porphobilinogen NADPH phosphoribosyltransferase: hpt adenosine kinase: Nucleotide Degradation acpS 1402 AFER_RS04345 kinase: ndk AFER_RS08740 AFER_RS12470 MptB: mptB methylcytidine CAIR AFER_RS02535 a dodecanoyl- a malonyl-[RedL a 3-oxo-3-(1H 7,8-dihydroneopterin in 16S rRNA menaquinol-13 gln pyrimidine deoxyribonucleotides glutaminyl-tRNA Aminoacyl-tRNA Charging [RedQ acyl- polyketide -pyrrol-2-yl) an N-formyl- a holo [peptidyl- 2'-phosphate tRNA charging dGTP dATP IMP AMP dephosphorylation 3',5'-ADP biosynthesis via transamidation carrier protein] synthase] propanoyl-[RedN] L-methionyl- a tetrahydrofolate carrier protein] (S)-3- MazG nucleotide acetoacetate [initiator tRNA met ] aminobutanoyl-CoA pyrophosphohydrolase: glu cys Cys a tRNA AFER_RS08245 4-hydroxy- dCTP dCMP a 3-oxotetradecanoyl- Carbohydrate Degradation a [glycine-cleavage (indol-3-yl) ser asp Ala AsbD acyl- 7,8-dihydroneopterin N-formimino- an L-aspartyl- ser a tRNA tRNA asp a tRNA ala 2,2'-bipyrrole- a sulfurated [sulfur carrier] SAM complex H protein] coenzyme A glu a (6S)-5- (S)-NADPHX 15-cis-phytoene elongator [RedL polyketide carrier protein 2',3'-cyclic phosphate [tRNA Asn ] acetamide cysteine-- val Val met Met met pro Pro trp Trp ile Ile thr Thr gly Gly leu Leu glu glu tyr Tyr arg Arg lys Lys phe Phe 5-methanol N 6 -octanoyl-L-lysine formyltetrahydrofolate L-glutamate gln a tRNA Met initiator tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA synthase] (1,4)-β-D-xylan dUTP diphosphatase: dut polyprenol Asp-tRNA(Asn) amidase: NAD(P)H-hydrate phytoene tRNA ligase: tRNA D-mannose degradation formimidoylglutamate an L-glutamyl- Asn Gln His degradation MazG nucleotide phosphomannose- /Glu-tRNA(Gln) AFER_RS01195 dehydratase: desaturase: serine- AFER_RS01580 aspartate- alanine- asn tRNA gln a tRNA his a tRNA holo-ACP deiminase: imidazole [tRNA Gln ] pyrophosphohydrolase: folylpolyglutamate dependent alpha 1,6 amidotransferase: [+ 2 isozymes] AFER_RS02245 crtI -tRNA cysteine-- valine- methionine-- methionine-- -tRNA proline-- tryptophan- -tRNA isoleucine-- threonine-- glycine-- leucine-- glutamate-- tyrosine-- arginine-- lysine- phenylalanine- β D-mannopyranose lipoyl AFER_RS07305 glycerol 4-hydroxy-2,2'- a (1->4)- -D-xylan AFER_RS08245 synthase: synthase: mannosyltransferase gatB gatA gatC 9,15,9'-tri-cis Asp-tRNA(Asn) ligase: tRNA ligase: -tRNA tRNA ligase: tRNA ligase: ligase: tRNA ligase: -tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: -tRNA -tRNA ligase: 5-undecyl-1,2- 6-phosphate synthase: lipA N-formyl- an L-asparaginyl- (indol-3-yl)acetate NADPH phosphate bipyrrole-5- bifunctional dUTP dUMP acpS AFER_RS10875 MptB: mptB -ζ-carotene alaS dihydropyrrol- Asn synthase: /Glu-tRNA(Gln) serS AFER_RS06335 ligase: valS AFER_RS02700 AFER_RS02700 aspS AFER_RS03260 ligase: trpS AFER_RS06235 AFER_RS06330 AFER_RS06505 AFER_RS06795 AFER_RS07905 AFER_RS08410 AFER_RS09370 ligase: lysS pheT pheS carbaldehyde phosphoglucose/ 7,8-dihydroneopterin L-glutamate [tRNA ] amidotransferase: 3-one a (1->4)-β-D-xylan hisF hisH phosphomannose a [glycine-cleavage a holo-[AsbD acyl- 3'-phosphate an L-methionyl- oligosaccharide 5'-deoxyadenosine 6 an unsulfurated 3',5'-ADP a (6S)-5- gatB gatA gatC an L-seryl- an L-cysteinyl- an L-valyl- an L-methionyl- an L-aspartyl- an L-prolyl- an L-tryptophanyl- an L-alanyl- an L-isoleucyl- an L-threonyl- an L-leucyl- an L-glutamyl- an L-tyrosyl- an L-arginyl- an L-lysyl- an L-phenylalanyl- an L-asparaginyl- an L-glutaminyl- an L-histidyl- isomerase: 5-hydroxy-CTP 5-hydroxy-CMP met complex H protein] N [+ 6 isozymes] [elongator a glycyl-[tRNA Gly ] carrier protein] formyltetrahydrofolate a 5-phosphooxy- [tRNA ser ] [tRNA Cys ] [tRNA Val ] [initiator tRNA Met ] [tRNA asp ] [tRNA Pro ] [tRNA Trp ] [tRNA Ala ] [tRNA Ile ] [tRNA Thr ] [tRNA Leu ] [tRNA Glu ] [tRNA Tyr ] [tRNA Arg ] [tRNA Lys ] [tRNA Phe ] [tRNA Asn ] [tRNA Gln ] [tRNA His ] xylan 1,4-beta- -[(R)-lipoyl]-L-lysine [sulfur carrier] Met 4-methoxy- AFER_RS09120 L-glutamyl- tRNA ] xylosidase: ammonium 2,2'-bipyrrole- F6P [tRNA Gln ] 2-undecylpyrrole AFER_RS00870 5-carbaldehyde GDP-α-D- trans,octacis an apo-[LYS2 L- a 5-aminomethyl-2- a guanine 37 (R)-2,3-dihydroxy- γ-glutamyl- β-D-xylopyranose coenzyme A coenzyme A [EntB aryl- an L-glutamyl- chorismate Asp-tRNA(Asn) mannose -decaprenyl 2-aminoadipyl- 34 carrier protein] thiouridine in tRNA in tRNA [tRNA Gln ] 3-methylpentanoate isopropylamide /Glu-tRNA(Gln) phosphate carrier-protein] tRNA(5- tRNA Asp-tRNA(Asn) dihydroxy-acid ferredoxin: chorismate amidotransferase: methylaminomethyl- (guanosine(37)-N1) /Glu-tRNA(Gln) dehydratase: AFER_RS02880 polyprenol holo-ACP holo-ACP mutase: aroH gatB gatA gatC undecylprodigiosin 2-thiouridine)- -methyltransferase amidotransferase: ilvD [+ 3 isozymes] monophosphomannose synthase: synthase: methyltransferase: TrmD: trmD an N 1 - gatB gatA gatC (3S)-3-methyl-2- N-(γ-L-glutamyl) synthase: AFER_RS04460 acpS acpS an L-glutaminyl- prephenate an L-glutaminyl- AFER_RS08060 37 oxopentanoate -L-alaninol methylguanine Gln Gln a 5-methylaminomethyl- [tRNA ] [tRNA ] trans,octacis- in tRNA Alcohol Degradation a holo-[LYS2 L- 2-thiouridine 34 in tRNA decaprenylphospho- a holo-[EntB aryl- streptorubin B GDP 3',5'-ADP 2-aminoadipyl- 3',5'-ADP β-D-mannose carrier protein] glycerol and glycerophosphodiester degradation carrier-protein] glycerol degradation V

glycerol glycerol CoB-CoM a [2-oxoglutarate guanine 37 a [protein]-α- a glycerophosphodiester dihydromethanophenazine coenzyme A an apo-[aryl- coenzyme A [EntF L-seryl- citrate (S)-NADHX MeOH heterodisulfide dehydrogenase E2 protein] in tRNA Phe L-glutamate carrier protein] carrier protein] 6 N -dihydrolipoyl-L-lysinedihydrolipoyl tRNA protein-glutamate O- aconitate NAD(P)H-hydrate catalase/ glycerophosphoryl dihydroxyacetone dehydrogenase: (guanosine(37)-N1) methyltransferase hydratase: dehydratase: peroxidase heterodisulfide holo-ACP glycerol diester holo-ACP lpdA -methyltransferase CheR: AFER_RS07275 AFER_RS02245 HPI: katG dihydroxyacetone reductase synthase: synthase: TrmD: trmD AFER_RS01105 phosphodiesterase: [+ 2 isozymes] an N 1 - a [protein]-L- kinase subunit subunit B: acpS acpS a [2-oxoglutarate D-threo-isocitrate NADH formaldehyde glycerol kinase AFER_RS08065 methylguanine 37 glutamate-O 5 DhaK: dhaK AFER_RS04965 dehydrogenase E2 6 Phe GlpK: glpK glycerophosphodiester a holo-[EntF protein] N -lipoyl-L-lysine in tRNA -methyl-ester a holo-[aryl- glycerol kinase: phosphodiesterase: DHAP 3',5'-ADP 3',5'-ADP L-seryl-carrier carrier protein] AFER_RS07615 AFER_RS11220 coenzyme M coenzyme B methanophenazine protein]

sn-glycerol 3-phosphate a [pyruvate dehydrogenase E2 a 2,3,4-saturated 3,4-dihydroxyphenylacetyl- an N-terminal L- dCDP a uracil 1498 (2S)- oxaloacetate ethanol a sulfurated [sulfur carrier] 6 alanyl-[S18 protein Amine and Polyamine Degradation SAM protein] N -octanoyl-L-lysine 1,2-diacyl-sn- CoA ribonucleoside- in 16S rRNA ethylmalonyl-CoA CTP of 30S ribosome] 16S rRNA glycerol 3-phosphate ribosomal protein diphosphate reductase methylmalonyl- catalase/ (uracil(1498)-N(3))- citrate synthase: allantoin degradation hydroxyphenylacetyl- S18-alanine N- adenosylcobalamin- CoA peroxidase methyltransferase: AFER_RS09475 DHAP to ureidoglycolate II putrescine degradation IV phosphatidate CoA thioesterase acetyltransferase: dependent: epimerase: mce HPI: katG AFER_RS06650 lipoyl synthase: lipA cytidylyltransferase: rimI an N 3 - (2R)- (ammonia producing) PaaI: paaI an N-terminal N-acetyl- AFER_RS05255 citrate acetaldehyde AFER_RS11525 1498 ethylmalonyl-CoA (S)-(+)-allantoin putrescine L-alanyl-[S18 protein CDP methyluracil (3,4- of 30S ribosome] in 16S rRNA a [pyruvate dehydrogenase coenzyme A 5'-deoxyadenosine a CDP-2,3,4-saturated- dihydroxyphenyl) met 6 E2 protein] N -lipoyl-L-lysine an unsulfurated [sulfur carrier] diacylglycerol acetate allantoate 4-aminobutanal allantoate UDP-N-acetyl-α-D-muramoyl-L- a single- 1518 UDP phosphoenol amidohydrolase: a lipid II adenine / (S)-dihydroorotate a double propionamide γ 1519 AFER_RS07300 gamma- alanyl- -D-glutamyl-meso-2,6- stranded RNA adenine in 16S rRNA ribonucleoside- stranded DNA pyruvate ribosomal RNA aminobutyraldehyde diaminopimeloyl-D-alanyl-D-alanine diphosphate reductase DNA gyrase: amidase: (S)-ureidoglycine small subunit dihydroorotase: pyruvate dehydrogenase: polyribonucleotide adenosylcobalamin- AFER_RS00020 AFER_RS01195 1-pyrroline penicillin-binding methyltransferase AFER_RS08810 kinase: pyk AFER_RS02925 penicillin-binding protein 2: mrdA nucleotidyltransferase: dependent: gyrA [+ 2 isozymes] 6 A: rsmA 1518 a negatively protein 2: mrdA AFER_RS03305 N -dimethyladenine AFER_RS05255 N-carbamoyl- propanoate pyruvate 6 1519 supercoiled DNA /N -dimethyladenine dUDP L-aspartate 4-aminobutanoate a N-acetylglucosamine--N- (S)-ureidoglycolate in 16S rRNA UDP-N-acetylmuramoyl-L- D-ala acetylmuramyl-(tetrapeptide) a nucleoside a single- putrescine degradation I D-ala alanyl-γ-D-glutamyl-meso-2,6- pyrophosphoryl-undecaprenol diphosphate stranded RNA diaminopimeloyl-D-alanine putrescine

a [2-oxoglutarate dehydrogenase E2 a ribonucleoside a double-stranded an insertion sequence 4-imidazolone- 4-hydroxybutanoate acetyl-CoA a single a nucleoside homogentisate (S)-malate protein] N 6 -dihydrolipoyl-L-lysine triphosphate oligonucleotide element IS30 5-propanoate 4-aminobutanal stranded DNA triphosphate multifunctional oxoglutarate transposase: homogentisate malate urocanate MazG nucleotide oligoribonuclease: decarboxylase/oxoglutarate AFER_RS11400 1,2-dioxygenase: dehydrogenase: hydratase: gamma- 4-hydroxybutyrate DNA pyrophosphohydrolase: orn Carboxylate Degradation dehydrogenase thiamine [+ 49 isozymes] AFER_RS04190 AFER_RS09720 hutU aminobutyraldehyde CoA-transferase: primase: AFER_RS08245 pyrophosphate-binding a nucleoside 5'- an insertion 4-maleyl- dehydrogenase: AFER_RS04270 dnaG a nucleoside 5'- oxaloacetate urocanate subunit/dihydrolipoyllysine- monophosphate sequence IS30 with acetoacetate propanoyl CoA AFER_RS02925 monophosphate integrated transposon acetate residue succinyltransferase degradation I subunit: AFER_RS08950 4-hydroxybutanoyl- conversion 4-aminobutanoate acetate ssDNA/pppN(pN) a [2-oxoglutarate dehydrogenase E2 CoA propanoyl-CoA to acetyl-CoA hybrid protein] N 6 -S-succinyldihydrolipoyl-L-lysine n -1 acyl-CoA acetate carboxylase acetate--CoA (1R,6R)-6-hydroxy-2- subunit beta: ligase: acs an N-terminal a [DNA]-3'- (S)-2-aceto-2- (S)-4-amino-5- cytidine an L-phenylalanyl- glycyl-glycine glutathione succinylcyclohexa-2,4- ferroheme o pyrazinamide AFER_RS01185 acetate-- arginyl-[protein] Phe hydroxyl hydroxybutanoate oxopentanoate nucleoside [tRNA ] diene-1-carboxylate glutamate-1- ketol-acid amidase: deaminase: acyl-CoA CoA ligase: semialdehyde heme A synthase: AFER_RS08505 o-succinylbenzoate reductoisomerase: AFER_RS01195 AFER_RS10455 carboxylase hypothetical gamma- exodeoxyribonuclease 2,1-aminomutase: AFER_RS00980 acetyl-CoA synthase: menC ilvC [+ 2 isozymes] subunit beta: protein: glutamyltransferase: III: xth AFER_RS01310 uridine (R)-2,3-dihydroxy- pyrazine-2- (S)-methylmalonyl-AFER_RS06935 AFER_RS06725 AFER_RS03590 ferroheme a 2-succinylbenzoate 3-methylpentanoate 5-aminolevulinate carboxylate CoA a 2'- γ-L-glutamyl- a [DNA]-3'- methylmalonyl- L-phenylalanyl-L- L-cysteinylglycine deoxyribonucleoside a tRNA Phe hydroxyl CoA arginyl-[protein] glycylglycine 5'-monophosphate epimerase: mce (R)-methylmalonyl- DNA combined with CoA an N-terminal an L-phenylalanyl- D-threo-7,8- a negatively exogenous DNA to form uroporphyrinogen-III oxaloacetate a uridine in tRNA (S)-malate hypothetical L-lysyl-[protein] [tRNA Phe ] dihydroneopterin supercoiled DNA a recombinational junctionHolliday junction phosphoenolpyruvate tRNA- type I DNA class II fumarate protein: uroporphyrinogen resolvase RuvX: ruvX carboxykinase (GTP) dihydrouridine topoisomerase: hydratase: AFER_RS03735 dihydroneopterin decarboxylase: hemE pyruvate decarboxylation to acetyl CoA I hypothetical : AFER_RS03570 synthase: topA AFER_RS09225 hypothetical crossover junction aldolase: protein: phosphoenol AFER_RS08795 protein: endodeoxyribonuclease AFER_RS09875 coproporphyrinogen III a 5,6-dihydrouridine a relaxed DNA fumarate a [pyruvate dehydrogenase AFER_RS06725 pyruvate AFER_RS09250 pyruvate resolution of recombinationalRuvC: ruvC in tRNA 6 pyruvate E2 protein] N -lipoyl-L-lysine dehydrogenase junction formation succinyl-CoA (acetyl-transferring) L-phenylalanyl- 6-(hydroxymethyl) glycolaldehyde a tRNA Phe of two intact strands , homodimeric L-lysyl-[protein] -7,8-dihydropterin dihydrolipoyl type: aceE dehydrogenase: lpdA [+ 2 isozymes] pyruvate a single 2-amino-6-[1-hydroxyethyl]- an (S)-2- dehydrogenase uroporphyrinogen-I oxaloacetate 4-guanidinobutyramide D-glucopyranose acetamide stranded DNA 7-methyl-7,8-dihydropterin halocarboxylate (acetyl-transferring) 2-amino-4-hydroxy-6- amidase: glucose 1- amidase: E1 component uroporphyrinogen citrate synthase: a [pyruvate dehydrogenase hydroxymethyldihydropteridine AFER_RS01195 dehydrogenase: AFER_RS01195 subunit alpha: pdhA haloacid decarboxylase: hemE AFER_RS09475 a [pyruvate dehydrogenase E2 6 exodeoxyribonuclease AFER_RS08440 E2 protein] N -S- diphosphokinase: folK dehalogenase: [+ 2 isozymes] [+ 2 isozymes] protein] N 6 -dihydrolipoyl-L-lysine acetyldihydrolipoyl-L-lysine VII large subunit: xseA [1-(2-amino-7-methyl-4-oxo- 1,2-dihydroxypropane- D-glucono- AFER_RS09555 coproporphyrinogen I 4-guanidinobutanoate acetate lipoate 7,8-dihydro-3H-pteridin- 1,2,3-tricarboxylate 1,5-lactone acetyltransferase: 6-yl)]ethyl diphosphate aceE a ribonucleoside a single-stranded a (2R)-2- oligodeoxyribonucleotide a halide anion citrate degradation 5'-monophosphate hydroxy fatty acid

an acetyl-holo [citrate lyase acyl- 3-methyl-2- 5,10-methylene- (2R,3S)-3- dCTP citrate acetyl-CoA a uridine 55 in tRNA HMG-CoA porphobilinogen 2-hydroxyisobutyramide D-glucopyranose carrier protein] oxobutanoate tetrahydromethanopterin isopropylmalate tRNA pseudouridine amidase: 3-isopropylmalate glucose 1- dCTP deaminase: synthase: AFER_RS10750 hydroxymethylbilane 3-methyl-2-oxobutanoate AFER_RS01195 dehydrogenase: dehydrogenase: AFER_RS00265 hydroxymethylglutaryl- synthase: hemC hydroxymethyltransferase: tRNA pseudouridine(55) CoA lyase: [+ 2 isozymes] AFER_RS07950 AFER_RS08440 a citryl-holo dUTP panB synthase TruB: truB AFER_RS05865 2-hydroxy-2- 4-methyl-2- D-glucono- [citrate lyase acyl- 55 preuroporphyrinogen Detoxification a pseudouridine in tRNA methylpropanoate oxopentanoate 1,5-lactone carrier protein] citryl-CoA lyase: reactive oxygen species degradation 2-dehydropantoate THMPT acetoacetate acetyl-CoA AFER_RS10480 phenylmercury acetate degradation oxaloacetate superoxide 2,5-diamino-6-(5- 10 CTP mercuriphenyl 4a-hydroxy-N - a single dihydroxyacetone (2R,3S)-3- 2'-deoxycytidine phospho-D-ribitylamino) uroporphyrinogen-III superoxide acetate formyltetrahydrofolate stranded DNA isopropylmalate nucleoside pyrimidin-4(3H)-one bifunctional uroporphyrinogen-III 3-isopropylmalate dCTP deaminase: dismutase, 4a-hydroxytetrahydrobiopterin deoxyribonuclease dihydroxyacetone deaminase: diaminohydroxyphosphoribosylaminopyrimidine C-methyltransferase: dehydratase: AFER_RS00265 Ni: sodN dehydratase: AFER_RS03740 IV: AFER_RS06360 kinase: dhaK dhaL AFER_RS10455 deaminase/5-amino-6-(5-phosphoribosylamino) cobA leuD leuC hydrogen 2'-deoxyuridine UTP peroxide uracil reductase RibD: ribD an N 10 -formyl- DHAP (2S)-2- 2+ 5-amino-6-(5-phospho- a 5'-phosphooligonucleotide precorrin-2 acetate benzene Hg 7,8-dihydrofolate isopropylmalate D-ribitylamino)uracil catalase/ mercury(II) peroxidase reductase: HPI: katG merA H O hydroxyl radical 2 Hg 0 O 2 a branched- a branched- chain a reduced chain a reduced amino acid plastocyanin amino acid plastocyanin an oxidized an oxidized an amino an amino plastocyanin sn-glycerol a carbohydrate plastocyanin (RS)-malate 3-phosphate ammonium acid acid predicted predicted ABC ABC transporter transporter cytochrome RS02230 RS06825 RS10325 RS09935 RS10360 RS06835 of a of a RS09415 c oxidase branched- branched- chain chain a carbohydrate amino acid amino acid (RS)-malate sn-glycerol ammonium an amino an amino O 3-phosphate acid acid 2 O H O 2 a branched- a branched- 2 H O 2 chain chain amino acid amino acid This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.