Pyrolysis of Hydrazine Derivatives and Related Compounds with N-N Single Bonds
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Transport of Dangerous Goods
ST/SG/AC.10/1/Rev.16 (Vol.I) Recommendations on the TRANSPORT OF DANGEROUS GOODS Model Regulations Volume I Sixteenth revised edition UNITED NATIONS New York and Geneva, 2009 NOTE The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. ST/SG/AC.10/1/Rev.16 (Vol.I) Copyright © United Nations, 2009 All rights reserved. No part of this publication may, for sales purposes, be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, electrostatic, magnetic tape, mechanical, photocopying or otherwise, without prior permission in writing from the United Nations. UNITED NATIONS Sales No. E.09.VIII.2 ISBN 978-92-1-139136-7 (complete set of two volumes) ISSN 1014-5753 Volumes I and II not to be sold separately FOREWORD The Recommendations on the Transport of Dangerous Goods are addressed to governments and to the international organizations concerned with safety in the transport of dangerous goods. The first version, prepared by the United Nations Economic and Social Council's Committee of Experts on the Transport of Dangerous Goods, was published in 1956 (ST/ECA/43-E/CN.2/170). In response to developments in technology and the changing needs of users, they have been regularly amended and updated at succeeding sessions of the Committee of Experts pursuant to Resolution 645 G (XXIII) of 26 April 1957 of the Economic and Social Council and subsequent resolutions. -
Triazene (H2NNNH) Or Triimide (HNHNNH) Markofçrstel,[A, D] Yetsedaw A
DOI:10.1002/cphc.201600414 Articles On the Formation of N3H3 Isomers in Irradiated Ammonia Bearing Ices:Triazene (H2NNNH) or Triimide (HNHNNH) MarkoFçrstel,[a, d] Yetsedaw A. Tsegaw,[b] Pavlo Maksyutenko,[a, d] Alexander M. Mebel,[c] Wolfram Sander,[b] and Ralf I. Kaiser*[a, d] The remarkable versatility of triazenesinsynthesis, polymer theoretical studies with our novel detection scheme of photo- chemistry and pharmacology has led to numerousexperimen- ionization-driven reflectron time-of-flight mass spectroscopy tal and theoretical studies.Surprisingly,only very little is we can obtain information on the isomersoftriazene formed known aboutthe most fundamental triazene:the parentmole- in the films. Using isotopically labeled starting material, we can cule with the chemical formula N3H3.Here we observe molecu- additionally gain insightinthe formation pathways of the iso- lar,isolated N3H3 in the gas phase after it sublimes from ener- mers of N3H3 under investigation and identify the isomers getically processed ammonia and nitrogen films. Combining formedastriazene (H2NNNH) andpossibly triimide(HNHNNH). 1. Introduction During the last decades, triazenes—a class of organic mole- life time of at least 1mswas also inferred as an intermediate cules carrying the =N N=N moiety—have received substan- in the radiolysis of an aqueous solution of hydrazine based on À À tial attention both from the theoretical and organic chemistry asingle absorption feature at 230 nm.[6] The cyclic isomer of [1] communities. Derived from cis-and trans-triazene (HN=NNH2 ; triazene, cyclotriazane, was first reported crystallographically in Scheme1), the substituted counterparts have significant appli- zeolite A, where it was stabilized by asilver cation as [1a,c] [1d] + [7] + cations in synthetic chemistry, polymer science, and phar- Ag(N3H3) . -
1,3,5-Triazine As Core for the Preparation of Dendrons
The Free Internet Journal Paper for Organic Chemistry Archive for Arkivoc 2020, part iii, 0-0 Organic Chemistry to be inserted by editorial office 1,3,5-Triazine as core for the preparation of dendrons Rotimi Sheyi,a Anamika Sharma,a,b Ashish Kumar,a,b Ayman El-Faham,c,d Beatriz G. de la Torre,b,* and Fernando Albericioa,c,e,f* aPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4001, South Africa bKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa cDepartment of Chemistry, College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia dDepartment of Chemistry, Faculty of Science, Alexandria University, PO Box 426, Alexandria 21321, Egypt eInstitute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain fCIBER-BBN (Networking Centre on Bioengineering, Biomaterials and Nanomedicine) and Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain *Corresponding authors. email: [email protected]; [email protected] Received mm-dd-yyyy Accepted mm-dd-yyyy Published on line mm-dd-yyyy Dates to be inserted by editorial office Abstract A unique property of 2,4,6-trichloro-1,3,5-triazine (TCT) is its ability to undergoes a nucleophilic aromatic substitution reaction (SNAr) under temperature-controlled conditions. Using a convenient and biologically friendly protocol, mono-substituted s-triazines were treated with excess nucleophiles to obtain tri-substituted triazines in 1 + 2 mode (one nucleophile as the first substitution followed by another nucleophile for the other two positions). -
S-Triazine: a Privileged Structure for Drug Discovery and Bioconjugation
molecules Review s-Triazine: A Privileged Structure for Drug Discovery and Bioconjugation Anamika Sharma 1,2 , Rotimi Sheyi 1, Beatriz G. de la Torre 1,2 , Ayman El-Faham 3,4,* and Fernando Albericio 1,3,5,6,* 1 Peptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4001, South Africa; [email protected] (A.S.); [email protected] (R.S.); [email protected] (B.G.d.l.T.) 2 KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa 3 Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 4 Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 12321, Egypt 5 Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain 6 CIBER-BBN (Networking Centre on Bioengineering, Biomaterials and Nanomedicine) and Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain * Correspondence: [email protected] (A.E.-F.); [email protected] (F.A.) Abstract: This review provides an overview of the broad applicability of s-triazine. Our many years working with this intriguing moiety allow us to discuss its wide activity spectrum (inhibition against MAO-A and -B, anticancer/antiproliferative and antimicrobial activity, antibacterial activity against MDR clinical isolates, antileishmanial agent, and use as drug nano delivery system). Most Citation: Sharma, A.; Sheyi, R.; of the compounds addressed in our studies and those performed by other groups contain only de la Torre, B.G.; El-Faham, A.; N-substitution. -
Durham E-Theses
Durham E-Theses Halogenated diazines and triazines Wood, D. E. How to cite: Wood, D. E. (1978) Halogenated diazines and triazines, Durham theses, Durham University. Available at Durham E-Theses Online: http://etheses.dur.ac.uk/8324/ Use policy The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that: • a full bibliographic reference is made to the original source • a link is made to the metadata record in Durham E-Theses • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders. Please consult the full Durham E-Theses policy for further details. Academic Support Oce, Durham University, University Oce, Old Elvet, Durham DH1 3HP e-mail: [email protected] Tel: +44 0191 334 6107 http://etheses.dur.ac.uk UNIVERSITY OF Du'RKAM A THESIS entitled HALOGENATED DIAZINES AND TRIAZINES Submitted by D E. WOOD (Grey), B Sc (London) The copyright of this thesis rests with the author No quotation from it should be published without his prior written consent and information derived from it should be acknowledged A candidate for the degree of Doctor of Philosophy 19 78 sr i i > j J To my MoLhcr and FaLhcr WLLII Lh.inks for .ill LhaL Lhey have done ACKNOWLEDGEMLNTS I would like LO express my thanks Lo Professor R D Chambers i under whose guidance this research was undertaken, for considerable encouragement, advice and discussion Thanks are due to Dr R S Matthews for his expert advice with n in r. -
Risto Laitinen/August 4, 2016 International Union of Pure and Applied Chemistry Division VIII Chemical Nomenclature and Structur
Approved Minutes, Busan 2015 Risto Laitinen/August 4, 2016 International Union of Pure and Applied Chemistry Division VIII Chemical Nomenclature and Structure Representation Approved Minutes of Division Committee Meeting in Busan, Korea, 8–9 August, 2015 1. Welcome, introductory remarks and housekeeping announcements Karl-Heinz Hellwich (KHH) welcomed everybody to the meeting, extending a special welcome to those who were attending the Division Committee meeting for the first time. He described house rules and arrangements during the meeting. KHH also regretfully reported that it has come to his attention that since the Bangor meeting in August 2014, Prof. Derek Horton (Member, Division VIII task groups on Carbohydrate and Flavonoids nomenclature; Associate Member, IUBMB-IUPAC Joint Commission on Biochemical Nomenclature) and Dr. Libuse Goebels, Member of the former Commission on Nomenclature of Organic Chemistry) have passed away. The meeting attendees paid a tribute to their memory by a moment of silence. 2. Attendance and apologies Present: Karl-Heinz Hellwich (president, KHH) , Risto Laitinen (acting secretary, RSL), Richard Hartshorn (past-president, RMH), Michael Beckett (MAB), Alan Hutton (ATH), Gerry P. Moss (GPM), Michelle Rogers (MMR), Jiří Vohlídal (JV), Andrey Yerin (AY) Observers: Leah McEwen (part time, chair of proposed project, LME), Elisabeth Mansfield (task group chair, EM), Johan Scheers (young observer, day 1; JS), Prof. Kazuyuki Tatsumi (past- president of the union, part of day 2) Apologies: Ture Damhus (secretary, TD), Vefa Ahsen, Kirill Degtyarenko, Gernot Eller, Mohammed Abul Hashem, Phil Hodge (PH), Todd Lowary, József Nagy, Ebbe Nordlander (EN), Amélia Pilar Rauter (APR), Hinnerk Rey (HR), John Todd, Lidija Varga-Defterdarović. -
I. MATRIX ISOLATION of 1,1-DIAZENES II. DISTANCE, TEMPERATURE, and DYNAMIC SOLVENT EFFECTS on ELECTRON TRANSFER REACTIONS Thesis
I. MATRIX ISOLATION OF 1,1-DIAZENES II. DISTANCE, TEMPERATURE, AND DYNAMIC SOLVENT EFFECTS ON ELECTRON TRANSFER REACTIONS Thesis by James Edward Hanson In Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy California Institute of Technology Pasadena, California 1990 (Submitted September 8, 1989) 11 © 1990 James Edward Hanson All rights Reserved ill Acknowledgements I would like to thank my advisor, Peter Dervan , for his enthusiasm and support during my studies at Caltech. I would also like to thank Professor John Hopfield for his availability when I needed assistance with the theoretical complexities of the electron transfer work. I am deeply indebted to Lutfur "Zeta" Khundkar and Joe Perry for their expert assistance and collaboration in making measurements and understanding the implications of the results. Al Sylwester was extremely helpful in my first year as I began to work on 1,1-diazenes, and Alvin Joran and Burt Leland made my transition to the electron transfer project relatively simple. I should also thank those in the Dervan group who helped me with synthetic problems, especially John Griffin and Warren Wade. I appreciated discussions with some of the electron transfer experts at Caltech: Professor Rudy Marcus, Dave Beratan, Jose Onuchic, Dave Malerba, and Tad Fox. There were many times when the men in the chemistry shops provided invaluable assistance--you guys are the best! There are many who made my stay at Caltech enjoyable--I'll remember skiing with John and Linda Griffin and Heinz Moser, basketball (and marathons!) with Dave Kaisaki, tennis with Erich Uffelmann, and late night conversations with Kevin Luebke. -
Studies on New Vasodilators, Ws-1228 a and B Ii. Structure and Synthesis
VOL. XXXV NO. 2 THE JOURNAL OF ANTIBIOTICS 157 STUDIES ON NEW VASODILATORS, WS-1228 A AND B II. STRUCTURE AND SYNTHESIS HIROKAZU TANAKA, KEIZO YOSHIDA, YOSHIKUNI ITOH and HIROSHI IMANAKA Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan (Received for publication October 26, 1981) The structure of new hypotensive vasodilators, WS-1228 A and B, produced by Strepto- myces aureofaciens, were determined as I and 2, respectively, on the basis of their spectral and chemical evidences. WS-1228 A (1), having N-hydroxytriazene moiety, was synthesized from (E,E,E)-2,4,7- undecatrienal (4) by condensation with hydrazine hydrate followed by nitrosation. In the course of screening for new biologically active compounds, we found that Streptomyces aureofaciens produces hypotensive vasodilators designated as WS-1228 A (1) and B (2). Taxonomy, isolation and characterization of these compounds have been reported in the preceding papery. This report describes the structure elucidations of WS-1228 A (1) and B (2) and the synthesis of 1. WS-1228 A (1) WS-1228 B (2) WS-1228 A (1) was isolated as yellow needles [mp 100 - 102°C (dec.)] which showed a positive color reaction to ferric chloride reagent. Elemental analysis and mass spectrum established the molecular formula of 1 as C11H17N3O. Absorption bands at 1612 and 1580 cm-1 in its IR spectrum (Fig. 1) and at 300 nm in its UV spectrum suggested the presence of the triene oxime moiety. The PMR spectrum (Fig. Fig. 1. IR spectrum of WS-1228 A (1) (Nujol). 158 THE JOURNAL OF ANTIBIOTICS FEB. -
Synthetic Routes Towards Thiazolo[1,3,5]Triazines (Review)1
HETEROCYCLES, Vol. , No. , , pp. -. © The Japan Institute of Heterocyclic Chemistry Received, , Accepted, , Published online, . COM-06- (Please do not delete.) SYNTHETIC ROUTES TOWARDS THIAZOLO[1,3,5]TRIAZINES (REVIEW)1 Anton V. Dolzhenko School of Pharmacy, Curtin University of Technology, GPO Box U1987, Perth, Western Australia 6845, Australia, E-mails: [email protected]; [email protected] Abstract – The present review summarizes information on the synthetic approaches to thiazolo[3,2-a][1,3,5]triazines and polyfused systems bearing this heterocyclic core since the first report on this structure in 1887. The methods allowing access to the heterocyclic systems comprising isomeric thiazolo[3,4-a][1,3,5]triazine scaffold are also included in the review. Data concerning potential applications of the thiazolo[1,3,5]triazines, particularly as biologically active agents are discussed. Dedicated to Professor Viktor E. Kolla with my best wishes on the occasion of his 85th birthday CONTENTS 1. INTRODUCTION 2. SYNTHESIS OF THIAZOLO[3,2-a][1,3,5]TRIAZINES AND THEIR POLYFUSED ANALOGUES 2.1. Synthesis of thiazolo[3,2-a][1,3,5]triazines by annelation of the 1,3,5-triazine ring onto a thiazole scaffold. 2.1.1. Synthesis of thiazolo[3,2-a][1,3,5]triazines using Mannich condensation. 2.1.2. Synthesis of thiazolo[3,2-a][1,3,5]triazines using multicomponent reactions of thiazole derivatives with heterocumulenes. 2.1.3. Synthesis of thiazolo[3,2-a][1,3,5]triazines using other multicomponent reactions of 2-aminothiazoles and their derivatives. 2.1.4. Synthesis of thiazolo[3,2-a][1,3,5]triazines via reactions of 2-aminothiazoles with C-N-C triatomic synthons. -
Heterocyclic Compounds
Gábor Krajsovszky Heterocyclic compounds ISBN: 978-615-5722-01-1 © Gábor Krajsovszky Responsible editor: Gábor Krajsovszky Publisher’s reader: István Mándity Translated by Péter Tétényi Department of Organic Chemistry Pharmaceutical Faculty Semmelweis University Budapest, 2018 Acknowledgements The editor wants to express many thanks to Dr. István Mándity, who is Associate Professor and Director of Department of Organic Chemistry, for the careful proofreading service of the current manuscript, as well as to Dr. Péter Tétényi, who is Assistant Professor, for the translation to English language. Moreover, the editor renders many thanks to Mrs. Ferenc Juhász and Ms. Nikoletta Zlatzky laboratory assistants for drawing material of the figures. Dr. Gábor Krajsovszky Associate Professor Department of Organic Chemistry Literature used Alan R. Katritzky, Charles W. Rees: Comprehensive Heterocyclic Chemistry Parts 2-3, 4-6, 7 Pergamon Press 1984 Oxford • New York • Toronto • Sydney • Paris • Frankfurt T. Eicher, S. Hauptmann, A. Speicher: The Chemistry of Heterocycles Structure, Reactions, Syntheses, and Applications Wiley-VCH GmbH 2003 Weinheim E. Breitmaier, G. Jung: Organische Chemie Grundlagen, Stoffklassen, Reaktionen, Konzepte, Molekülstruktur Georg Thieme Verlag 1978, 2005 Stuttgart • New York Clauder Ottó: Szerves kémia II/2. Egyetemi jegyzet Semmelweis OTE Budapest, 1980 Bruckner Győző: Szerves kémia III−1. Tankönyvkiadó, Budapest, 1964 Természettudományi Lexikon − Harmadik kötet Clauder Ottó: 'Heterociklusos vegyületek' címszó, 155-161. -
Ger'g .Tyson Jr
July 14, 1964 ' G. N. TYSON, JR 3,140,582 ROCKET PROPULSION METHOD USING BORON AND NITROGEN COMPOUNDS Filed April 14, 1959 Ger'g .Tyson Jr. INVENTOR. I", u .12) ATTORNEYS 3,l4,582 Patented July 14,, 1964 2 The nitrogen containing compound and the boron con 3,140,582 taining compound are reacted in such proportions that all ROCKET PROPULSION METHOD USING BORON of the nitrogen and all of the boron react to produce AND NOGEN COMPOUNDS boron nitride, the carbon is released as elemental carbon George N. Tyson, Jr., Claremont, Calif., assignor to Olin Mathieson Chemical Corporation, a corporation of and large volumes of hydrogen gas are produced. Virginia Nitrogen containing compounds which can be employed Filed Apr. 14, 1959, Ser. No. 806,396 as reactants include the saturated hydronitrogens such 20 Claims. (Cl. 60-354) as ammonia, hydrazine, triazane, tetrazane; the unsaturated hydronitrogens such as diimide, triazene, tetrazene, iso This invention relates to a method for producing large 10 tetrazene, ammonium azide, hydrazine azide, and hydra volumes of hot gases in a short period of time, which zoic acid; alkyl hydrazines such as methyl hydrazine, un large volumes of hot gases are useful for many purposes symmetrical dimethyl hydrazine, ethyl hydrazine, unsym including imparting thrust to jet propelled devices such metrical diethyl hydrazine; alkylamines including mixed al as rockets. kylamines such as methylamine, dimethylamine, trimeth Jet propelled devices are essentially of two types: those 15 ylamine, ethylamine, diethylamine, triethylarnine, methyl which depend upon an external source for a portion of ethyl amine, n-propylamine, isopropylamine, di-n-propyl the propellant, and those in which the propellant is en amine, tri-n-propylamine, methyl propyl amine, ethyl prop tirely contained within the device. -
Tetrazine Ligand
Synthesis and photochemical studies of Cu(I) complex with 1,4-bis(3,5- dimethylpyrazol-1yl)tetrazine ligand Y. K Gun’ko,* H. Hayden Department of Chemistry, Trinity College Dublin, Dublin 2, Ireland 1. INTRODUCTION Nitrogen-rich compounds are unique very reactive substances which have high heats of formation. Pyridine is one of the most well known aromatic cycles where a CH is replaced by a nitrogen atom, but the pyridine ring is only one member of the azine heterocycles, in which one or more CH group of benzene is replaced by π-accepting and σ-donating nitrogen atoms, proceeding from diazines (pyridazines, pyrazine), triazines and up to tetrazines. Tetrazines are typical representatives of nitrogen rich heterocyclic compounds. They have a range of applications such as explosives,1 propellants and pyrotechnic ingredients,2 biological agents for recognition of anion3 and precursors for drug development. 4,5 Self-assembly of metal cations with nitrogen heterocyclic bridging ligands is a central theme in supramolecular chemistry aimed at developing assemblies of electronically coupled metal centres.6 These ligands can be used to bridge metal centres in various ways, allowing electron and charge transfer processes in the structures. 1,2,4,5-Tetrazines also have very interesting redox-behaviour, which are similar to quinones.7 The very low-lying π* orbital localised at the four nitrogen atoms in tetrazines might allow intense low-energy charge valence transfer absorptions, electrical conductivity of coordination polymers, unusual stability