Curriculum Vitae Octavian C. Ioachimescu, MD, PhD Revised: Dec 15th, 2014

Summary: Staff at Atlanta Veterans Affairs Medical Center (VAMC) and Associate Professor of Medicine at Emory University, with special interests and extensive activity in the fields of (1) Pulmonary, Critical Care and Sleep Medicine – obstructive airway diseases such as asthma, COPD and obstructive sleep apnea (OSA), (2) Predictive Health, (3) Medical Education in Pulmonary, Critical Care and Sleep Medicine, and (4) Organizational Leadership (as Atlanta VAMC Sleep Medicine Center Medical Director and Sleep Section Chief).

1. Name: Octavian C. Ioachimescu

2. Office Address: Atlanta VA Medical Center (VAMC) Sleep (111) 1670 Clairmont Rd. Decatur, GA 30033 Telephone: 404-321-6111 ext. 7258 (O) 216-346-8175 (C) Fax: 404-417-2903

3. E-mail Address: [email protected] or [email protected]

4. Citizenship: Romanian Citizen; US Permanent Resident

5. Current Titles and Affiliations: a. Academic appointments: 1. Primary appointments: Associate Professor of Medicine, Emory University, School of Medicine, 2013 – present 2. Joint and secondary appointments: Adjunct Clinical Assistant Professor of

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Medicine, Morehouse School of Medicine, 2009 – present b. Clinical appointments: 1. Medical Director, Sleep Disorders Center, Atlanta VAMC, 2007 – present (renamed in 2013 Sleep Medicine Center) 2. Medical Director, Respiratory Therapy Department, Atlanta VAMC, 2009 - 2012 3. Section Chief, VA Sleep Medicine Section, August 2012 – present c. Education appointments: Emory Sleep Medicine Fellowship VA Site Director and Core Faculty – June 2012 - present

6. Previous Academic and Professional Appointments: Clinical Instructor, , Carol Davila University, , , 1998 – 2000 Assistant Professor of Medicine, Emory University, School of Medicine, 2007–2013

7. Previous Administrative and/or Clinical Appointments: Acting Chief, Pulmonary Section, Atlanta VAMC, June 2009 – August 2010

8. Licensures/Boards: Ohio, 2006 – 2012 (let intentionally lapse) Georgia, issued 2008 - present

9. Specialty Boards: Romanian Board of Pulmonology - 2000 American Board of Internal Medicine - 2003 American Board of Internal Medicine - Pulmonary Medicine - 2005 American Board of Internal Medicine - Critical Care - 2006 American Board of Sleep Medicine - 2007

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10. Education: 1989 - 1995: Medical School: Carol Davila University of Medicine and Pharmacy, Bucharest, Romania 1999 - 2008: PhD: Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

11. Postgraduate Training: Residency and Fellowship in Pulmonary Medicine, Marius Nasta National Institute of Pneumology, Bucharest, Romania, Supervisor: Paul Stoicescu, MD, PhD, 1996 – 2000

Residency in Internal Medicine, Danbury Hospital, Danbury, CT (Yale University), Supervisor: Paul B. Iannini, MD, 2000 – 2003

Fellowship in Pulmonary Medicine and Critical Care, Cleveland Clinic Foundation, Cleveland, OH, Supervisor: Peter Mazzone, MD and Alex Arroliga, MD, 2003 – 2006

Fellowship in Sleep Medicine, Cleveland Clinic Foundation, Cleveland, OH, Supervisor: Nancy Foldvary-Schaefer, DO, 2006 – 2007

Leadership training: "VA Southeast Network 7 Physician Leadership Academy", 2009

"Leadership in Healthcare" - Advisory Board Company (including Harvard School of Business online modules), 2009 – 2011

"Junior Faculty Development Course", Emory University School of Medicine, Director: Sharon W. Weiss, MD, 2009

"Cleveland Clinic’s Executive Education" webinar (Dr. James K. Stoller, Developing Healthcare Leaders for the Future, Director: James K. Stoller), 2011

"Cleveland Clinic’s Executive Education" webinar (Dr. Carol Farver: Emotional Intelligence: An Essential Competency for Healthcare Providers, Director: James K.

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Stoller), 2011

"Cleveland Clinic’s Executive Education" webinar (Dr. Kenneth Goodman, Harnessing Clinical Resources at the Point of Care, Director: James K. Stoller), 2012

" Executive Program" (PEP 2013), Emory University, Departments of Pediatrics, Internal Medicine, & Surgery, January – June 2013

“Academy of Medical Educators”, Emory University, 2013-2014

“American College of Chest Physicians (ACCP) Leadership Academy”, Austin, TX, October 2014

12. Military or Government Service: Romanian Army Mandatory Military Service, Infantry/Sanitary Forces, 1988 – 1989

13. Committee Memberships:

National and International:

American College of Chest Physicians (ACCP, approximately 12,000 members from >100 countries) - ACCP Clinical Pulmonary Medicine Network Steering Committee Member (12-member committee; Clinical Pulmonary Medicine Network has >4700 members), 2010 – present

American Academy of Sleep Medicine (AASM, approximately 10,000 members from >70 countries) – AASM Education Committee Member (8- member committee), 2011 – 2014

American College of Chest Physicians (ACCP, approximately 12,000 members from >100 countries) –ACCP Clinical Pulmonary Medicine Network E-Community Co-Chair/Moderator, 2011 – 2012

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American College of Chest Physicians (ACCP, approximately 12,000 members from >100 countries) - ACCP Clinical Pulmonary Medicine Network Steering Committee Vice Chair (12-member committee; Clinical Pulmonary Medicine Network has >4700 members), 2012 – 2014

American College of Chest Physicians (ACCP, approximately 12,000 members from >100 countries) - ACCP Clinical Pulmonary Medicine Network Steering Committee Chair (12-member committee; Clinical Pulmonary Medicine Network has >4700 members), 2014 – 2016

American College of Chest Physicians (ACCP, approximately 12,000 members from >100 countries) - ACCP Clinical Pulmonary Medicine Network Steering Committee Past Chair (12-member committee; Clinical Pulmonary Medicine Network has >4700 members), 2016 – 2018

American Sleep Medicine Foundation (ASMF) Educational Projects Award Task Force Member (5-member committee) – Grant Reviewer, 2012, 2013, 2014

Veterans Affairs Critical Care Network (CCN) Organizing Committee Member (5 members) - 2012 – present

VA Research Project CSP-574 Clinical Evaluation Committee (CEC) Member (5 members), 2013 – present

American Federation of Medical Research (AFMR) Membership Committee Member (8 members), 2014 - present

b. Regional and State:

Veterans Inter Service Network 7 (VISN-7) Lung Cancer OncWatch

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Committee Member, 2007 – 2011

Ad-hoc Organizing Committee Member for Georgia Association of Sleep Professionals (GASP), 2008

Member of the Board of Directors (BOD, VA/Emory Facility) for Georgia Association of Sleep Professionals (GASP), 2012 – 2014

President, Georgia Association of Sleep Professionals (GASP) 2015 – 2016

c. Institutional:

Emory University Pulmonary and Critical Care Individualized Training Pathway Committee Member (6-member committee), Division of Pulmonary, Allergy and Critical Care Medicine, 2009 – 2010

Emory University Pulmonary and Critical Care Clinical Competency Committee Member (8-member committee), Division of Pulmonary, Allergy and Critical Care Medicine, 2009 – 2012

Emory University Objective Structured Clinical Examination (OSCE) Committee Member (8-member committee), Division of Pulmonary, Allergy and Critical Care Medicine, 2010 and 2013

Emory University Institutional Review Board (IRB) Member, 2010 – 2013

Emory University Sleep Center Education Strategic Planning Committee Member (5-member committee), 2010 – 2012

Emory University Sleep Medicine Clinical Competency Committee Member (5-member committee), Sleep Medicine Fellowship, 2012 – present

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Emory University Sleep Medicine Fellowship Committee Member (5-member committee), 2010 – present

Data Safety and Monitoring Board (DSMB) Member (5-member committee), Study: "Vitamin D for enhancing the immune system in cystic fibrosis (DISC)", PI: Vin Tangpricha, 2012 – present

Data Safety and Monitoring Board (DSMB) Chair (4-member committee) - Study “Lung Immune Dysfunction in HIV: the Role of Zinc and Oxidative Stress”, PI: Sushma Cribbs, 2014 – present

Emory University Department of Medicine Research Advisory Team (RAT) Committee Member, 2014 - present

14. Consultantships: - Takeda, Inc. – consultant for new sleep trial design - 2013 - 2014

15. Editorships and Editorial Boards: Editor and Member of International Advisory Board - The Journal of College Medical Sciences (JCMS), 2010 – present Editor and Member of Scientific Advisory Board - North American Journal of Medical Sciences (NAJMS), 2011 - present Editor of “Contemporary Sleep Medicine”, Bentham Publishing, 2011 (electronic textbook in patient and physician versions)

16. Ad-hoc Manuscript Reviewer for the Following Publications: i. “Chest”, 2001 - present ii. “Thorax”, 2004 - present

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iii. “Respirology”, 2004 - present iv. “Respiratory Care”, 2004 - present v. "Respiration", 2004 - present vi. “Respiratory Medicine”, 2006 - present vii. "Mayo Clinic Proceedings”, 2006 - present viii. “Heart & Lung: The Journal of Acute and Critical Care”, 2006 - present ix. “American Journal of Medical Sciences”, 2006 – present x. “Archivum Immunologiae et Therapiae Experimentalis”, 2007 xi. “Basic & Clinical Pharmacology & Toxicology”, 2006 - 2007 xii. "Current Respiratory Medicine Reviews", 2009 xiii. "Hospital Physician Board Review Manual" 2009 xiv. “Pneumologia”, 2000 - present xv. “Saudi Medical Journal”, 2007 - present xvi. “The International Journal of and Lung Disease”, 2010 – present xvii. “Therapeutic Advances in Respiratory Disease”, 2010 - present xviii. "Pediatric Pulmonology", 2010 - present xix. "Allergy and Asthma Proceedings", 2010 - present xx. "Medicine", 2010 - present xxi. "Orphanet Journal of Rare Diseases", 2010 - present xxii. "PLOS One", 2010 - present xxiii. "Journal of Public Health and Epidemiology", 2011 - present xxiv. "US Respiratory Disease", 2011 – 2012 xxv. “North American Journal of Medical Sciences”, 2011 – present xxvi. "International Journal of Medicine and Medical Sciences", 2012 – present xxvii. "Journal of Zhejiang University-Science", 2012 – present xxviii. "American Journal of Respiratory and Critical Care Medicine", 2012 – present xxix. "Sleep Medicine Reviews", 2013 – present xxx. "Chronobiology International", 2013 – present xxxi. “Cleveland Clinic Journal of Medicine”, 2013 – present xxxii. “Lung”, 2013 – present xxxiii. “European Journal of Pediatrics”, 2014 - present

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xxxiv. “Acta Endocrinologica”, 2014 – present xxxv. “Pediatrics International”, 2014 – present xxxvi. “Case Reports in Pediatrics”, 2014 – present xxxvii. “Canadian Respiratory Journal”, 2014 - present

17. Honors and Awards: Ioachimescu O.C. “Considerations about right ventricular function assessment in patients with COPD”, 1999, Pneumologia 2: 115-119 Article awarded ‘The best article of the year 1999’, Romania Ioachimescu O.C. “Bronchial-associated lymphoid tissue lymphoma”, American College of Physicians (ACP) Connecticut Meeting, May 2001 Joseph Belsky Award - 3rd Prize, Danbury Hospital Ioachimescu O.C. “Langerhans cell histiocytosis”, Danbury Hospital Research Day, May 2001 Joseph Belsky Award - 2nd Prize, Danbury Hospital Ioachimescu O.C. “The diagnosis and severity of OSA: a comprehensive analysis of different predictive models”, Neuroscience Day, Cleveland Clinic, May 2007, 3rd Prize Research Award, Cleveland Clinic Ioachimescu O.C. Three chapters in Encyclopedia of Respiratory Medicine, Editors: Geoffrey J. Laurent and Steven D. Shapiro, © 2006 Elsevier Ltd, ISBN (Set): 0-12-438360-2, Winner of the Best Multi-Volume Reference Work (Science), 2006 Professional/Scholarly Publishing Division of the Association of American Publishers (AAP) Ioachimescu O.C. "Teacher of the Year" Pulmonary Division Award, 2009 Ioachimescu O.C. - Marquis Who's Who in America 2010 and 2012 (64th and 65th Editions) Ioachimescu O.C. - among "The Most Influential Teachers in the Emory University Department of Medicine" (2010 Award Celebration) Ioachimescu O.C. - Marquis Who's Who in Science and Engineering 2011-2012 (11th Edition)

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Ioachimescu O.C. "Teacher of the Year" Pulmonary Division Award, 2012

18. Society Memberships: i. Romanian Society of Cardiology (RSC), 1996 – present ii. Romanian PsychoNeuroEndocrinology Society (RPNES), 1996 – 2000 iii. International Society of Endocrinology (ISE) 1997 – 1999 iv. Romanian Society of Pneumology (RSP), 1998 – present v. American College of Physicians (ACP), Affiliate, 2000 – 2007 vi. Society of Critical Care Medicine (SCCM), 2003 – 2007 vii. American College of Chest Physicians (ACCP), Affiliate, 2003 – 2009 viii. American Medical Association (AMA), 2000 - 2009 ix. European Respiratory Society (ERS, approximately 10,000 members from >100 countries), ERS Thoracic Oncology Assembly - Lung Cancer Group (11.01), 2003 – present x. American Thoracic Society (ATS approximately 15,000 members worldwide), ATS Assembly on Clinical Problems (CP), 2003 – present xi. Alpha-1 Antitrypsin Foundation (A1ATF), 2003 – 2012 xii. American Academy of Sleep Medicine (AASM approximately 10,000 members worldwide), Diplomate (DAASM), AASM Sleep Disordered Breathing Section, 2006 – present xiii. American College of Physicians (ACP), Fellow (FACP), 2007 – 2012 xiv. American Academy of Neurology, 2006 – 2008 xv. Georgia Association of Sleep Professionals (GASP), 2008 – present xvi. American College of Chest Physicians (ACCP, approximately 12,000 members from >100 countries), Fellow (FCCP), member of the ACCP Sleep Institute/Network, Pulmonary Physiology, Function, and Rehabilitation Network, Thoracic Oncology Network, and Clinical Pulmonary Medicine Network, 2009 – present xvii. Southern Society of Clinical Investigation (SSCI), 2009 – present

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xviii. American Federation of Medical Research (AFMR), 2012 - present

19. Organization of National or International Conferences: a. Administrative positions: 1. Vice-Chair of Clinical Pulmonary Medicine Network Steering Committee, ACCP, 2012- 2014 (organization of ACCP international meeting [“CHEST”]) 2. Chair of Clinical Pulmonary Medicine Network Steering Committee, ACCP, 2014- 2016 (organization of ACCP international meeting [“CHEST”]) 3. Past Chair of Clinical Pulmonary Medicine Network Steering Committee, ACCP, 2016- 2018 (organization of ACCP international meeting [“CHEST”]) b. Sessions as Chair: - Chair, American College of Chest Physicians (ACCP) "Lung Course", part of ACCP Board Review Courses, Phoenix, AZ, 2012

- Chair, American College of Chest Physicians (ACCP): “Predictive Health in Pulmonology: The Case of the Pulmonary Nodules” (Clinical Pulmonary Medicine Network Highlights Session), ACCP meeting, Atlanta, GA, 2012

- Co-Chair, American College of Chest Physicians (ACCP): “Pulmonary. Physiology” Plenary Session, ACCP meeting, Atlanta, GA, 2012

- Chair, Georgia Association of Sleep Professionals (GASP) Annual Meeting, April 2013

- Chair, American College of Chest Physicians (ACCP): “Obstructive Lung and Airway Disorders: to Split or to Lump?” Clinical Pulmonary Medicine Plenary Session, ACCP international meeting, Chicago, IL, 2013

20. Research Focus: Sleep Medicine Octavian C. Ioachimescu, MD, PhD - Curriculum Vitae 12/15/2014 Page 11/37

1. Predictive Health in Sleep Medicine - Obstructive Sleep Apnea (OSA) 2. Algorithms of diagnosis/therapy for OSA 3. Oxidative stress in OSA Pulmonology a. Predictive Health in Pulmonology (pulmonary nodules, pneumonia) b. Pulmonary nodules - computed tomographic volumetric analysis c. Orphan lung disorders d. Obstructive lung disease, pulmonary function

21. Grant Support: a. Active support: 1. Federally funded: - ESCAPe (CSP-574): ~ $300,000 (2011-2016) Study "Phase III randomized, placebo-controlled, double-blind clinical trial to evaluate the safety and efficacy of low-dose methylprednisolone infusion in subjects with severe community acquired pneumonia (ESCAPe)" (VA Central IRB Study #10-04, VA Cooperative Study CSP-574, NCT01283009), sponsor: Department of Veterans Affairs, Site Principal Investigator, 25% effort (current); - Sleep Telemedicine Assessment of Response to Therapy (START): $552,000 (2013- 2014) VA (Office of Rural Health)-sponsored, Investigator-Initiated Clinical Project to implement diagnosis and therapy of insomnia (CBTI) and sleep apnea using telemedicine capabilities and technologies, Emory IRB#00074996, Principal Investigator, 10% effort (current)

2. Contracts (industry-sponsored studies): - SUMMIT: ~ $80,000 (2011 - 2015) Phase III study HZC113782 (SUMMIT): "A Clinical Outcomes Study to compare the effect of Fluticasone Furoate/Vilanterol Inhalation Powder 100/25 mcg with placebo on Survival in Subjects with moderate Chronic Obstructive Pulmonary Disease (COPD) and a history of or at increased risk for cardiovascular disease"; industry-sponsored study, sponsor: GlaxoSmithKline (GSK, NCT01313676), Local Site Principal Investigator, Emory IRB

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00046472, 5% effort (current); - AUSTRI: ~$100,000 (2012 - 2015) Phase IV study SAS115359 (AUSTRI), "Safety and Efficacy Study of Inhaled Fluticasone Propionate/Salmeterol Combination versus Inhaled Fluticasone Propionate in the Treatment of Adolescent and Adult Subjects with Persistent Asthma"; industry-sponsored study, sponsor: GlaxoSmithKline (GSK, NCT01475721), Local Site Principal Investigator, Emory IRB 00055980, 5% effort (current); - CALIMA: ~$200,000 (2014-2016) Phase III study D3250C00018 (CALIMA), “A Multicentre, Randomized, Double-blind, Parallel Group, Placebo-controlled, Phase III Efficacy and Safety Study of Benralizumab (MEDI-563) Added to High-dose Inhaled Corticosteroid Plus Long-acting β2 Agonist in Patients with Uncontrolled Asthma (AstraZeneca, NCT01914757), Local Site Investigator, Emory IRB# 00073860, 5% effort (current) - SOLITAIRE-IV: ~50,000 (2014-2015) Phase III study CE01-301 (SOLITAIRE-IV): A Randomized, Double-Blind, Multi-Center Study to Evaluate the Efficacy and Safety of Intravenous to Oral Solithromycin (CEM-101) Compared to Intravenous to Oral Moxifloxacin in the Treatment of Adult Patients with Community-Acquired Bacterial Pneumonia, sponsor: Cempra Pharmaceuticals (NCT 01968733), Local Site Investigator, Emory IRB# 00074229, 5% effort (current)

b. Previous support: - Sleep Telemedicine Project: $150,000 (2012-2013) VA-sponsored, Investigator-Initiated Clinical Project to implement diagnosis and therapy of sleep disorders using telemedicine capabilities and technologies, Principal Investigator, 2.5% effort (past) - BREATH (CSP-560): $65,000 (2008 - 2009) Study "Bronchitis and Emphysema Advice and Training To Reduce Hospitalization (BREATH)" (Emory IRB# 00010180, NCT00395083), VA Cooperative Study CSP-560 (completed), sponsor: Department of Veterans Affairs, Local Site Principal Investigator; 10% effort (past);

c. Current Studies without Specific Support:

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- Study "Sleep Functional Outcomes" (Emory IRB# 00049576), investigator-initiated study, Principal Investigator, 2011 - 2016; 5% effort (current) - Study "Lung Transplant Functional Database" (Emory IRB#00052353), Co- Investigator (co-PIs: David Neujahr, Seth Force), 2011 - 2015; 1% effort (current) - Study "Respiratory Events and Risk of Hypertension" (Emory IRB# 00049576), Senior Investigator (Sub-Investigator and prior mentee: Ahmed Khan), 2011 - 2015; 1% effort (overlapping with "Sleep Functional Outcomes") - Study "Determinants of Functional Impairments in Pulmonary Function" (Emory IRB# 00049576), Senior Investigator (Sub-Investigator and prior mentee: Misbah Baqir), 2009 - 2015; 2.5% effort (overlapping with "Sleep Functional Outcomes") - Study "Functional Assessment in Sleep Apnea" (Emory IRB# 00049576), Senior Investigator (Sub-Investigator and prior mentee: Swathy Puthalapatthu), 2011 - 2015; 2.5% effort (current, overlapping with "Sleep Functional Outcomes") - Study "CPAP Therapy in Obstructive Sleep Apnea" (Emory IRB# 00049576), Senior Investigator (Co-Investigator and current mentee: Rina Eisenstein), 2011 - 2014; 2.5% effort (current, overlapping with "Sleep Functional Outcomes") -Study “CROSSEXAMINATION” (IRB waiver, #00059851), Co-Investigator (Co- investigator and current mentee: Faye Routledge), 2012-2015; 1% effort (current, data from Emory Predictive Health Initiative)

d..Past Studies without Specific Support: - Study: "Blood Collection for Structure Study" (Emory IRB# 00045762), Co - Investigator (Principal Investigator: Peter Wilson), 2011 - 2013; 2.5% effort (past) - Organizer of "National Registry of Orphan Lung Disorders", Principal Investigator, 1998, Romania, 10% effort (past) - Study "Gatifloxacin versus Trovafloxacin in acute bronchitis"; industry-sponsored study, Sub-Investigator (PI: Paul Stoicescu, MD, PhD), sponsor: Glaxo-Smith-Kline (GSK), Romania, 1999, 5% effort (past)

22. Clinical Service Contributions:  July 2007 – present: built and consolidated Atlanta VAMC Sleep Program, now

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Atlanta VAMC Sleep Medicine Center – grew from a 3-person Department (in 2007) to a 42-FTEE Sleep Medicine Center (in 2014) and a 3-million+ sleep contract over 3 years (as Medical Director of Sleep Medicine Center); since August 2012 – Sleep Medicine Section Chief  June 2009 – July 2010: led the Atlanta VAMC Pulmonary Section, in charge of >60 people (Pulmonary, Critical Care, Respiratory Therapy, Sleep Medicine and CPAP Clinics) (as Acting Pulmonary Section Chief)  July 2007 – present: attending for Pulmonary Consults, Medical ICU at the Atlanta VAMC: 2-4 months/year service, which includes: - Teaching - Patient care for MICU patients - Pulmonary Consults for wards or ICU inpatients - Pulmonary Special Clinic – outpatient consultations and procedures (including endobronchial ultrasound, EBUS)  July 2007 – present: Pulmonary Clinic for outpatients at the Atlanta VAMC: Monday half-day clinic; this involves teaching Pulmonary and Critical Care fellows  July 2007 – present: Sleep Center at the Atlanta VAMC: - Patient Care: Sleep Medicine consultations; full-day Sleep Clinic (Wednesday) - Review and interpret sleep studies performed in the Atlanta VA Sleep Lab (currently ~ 700 studies per year) - Oversee the development, implementation and quality control of outsourced sleep studies (600-1,200 polysomnographic studies per year) - Teaching for medical students, medical residents and Pulmonary and Critical Care fellows in Pulmonary Special Clinic or Sleep Medicine rotation  July 2012 – present: teaching Sleep Medicine fellows in Sleep Clinics and Laboratory

23. Formal Teaching: a. Medical Student Teaching:

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M5 Carol Davila University, Pulmonary Module, Marius Nasta Institute of Pneumology, Bucharest, Romania, 1999 - 2000 M3 Yale University and Columbia University, Danbury Hospital Internal Medicine rotations, 2000 - 2003 M3 Case Western-Cleveland Clinic University and Pennsylvania State University, Cleveland Clinic, Pulmonary and Critical Care rotations, 2003 - 2007 M1 Emory University, Pulmonary Module, 2009-2013 (except 2011) M2 Emory University, Evidence-Based Medicine Module, 2011 M3 Emory University, Critical Care VA Module, 2010-present b. Graduate Programs: Residency Programs - Internal Medicine Residents: Emory University, 2007 – present, and Morehouse School of Medicine, 2009 – present Fellowship Program - Pulmonary and Critical Care Medicine Fellows, 2007 – present Fellowship Program (Core Faculty and Site Director) - Sleep Medicine Fellows, 2012 – present

c. Other categories: Physician Assistant students, 2007 – present, occasionally Nurse Practitioner students, 2007 – present, occasionally Patients: Smoking cessation classes for patients, 2009-2010 Other Postgraduate - faculty for: Emory University ABIM Board Review Course (2009 – 2013, yearly) Atlanta School of Sleep Medicine Board Review Course (March and October 2009) Education Consultants Family Practice Board Review Course (May 2010, June 2010 and February 2012) Sleep Medicine Physician Assistants, 2011 – present, daily

24. Supervisory Teaching:

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Settings: Attending Physician for Pulmonary Consults at the Atlanta VAMC (M3, IM Residents and PCCM Fellows) Attending Physician for MICU Service at the Atlanta VAMC (M3, IM Residents and PCCM Fellows) Attending Physician for Pulmonary Clinics at the Atlanta VAMC (M3, IM Residents and PCCM Fellows) Attending Physician for Sleep Clinics and Sleep Laboratory at the Atlanta VAMC (IM Residents and PCCM Fellows) Mentees trained: i. Sleep Medicine Fellows mentored academically during Sleep Fellowship, as Chief Fellow: Dewey McWhirter 2006 - 2007 Private Practice in Tennessee Farid Talih 2006 - 2007 Faculty, American University of Beirut, Lebanon Esteban Linarez 2006 - 2007 Private Practice in Chicago, IL ii. Pulmonary and Critical Care Medicine (PCCM) Fellows mentored in research: Nimesh Shah 2009 - 2010 Staff, George Washington Hospital, DC Kavitha Kotha 2009 - 2010 Staff, University of North Carolina, NC Misbah Baqir 2010 - 2012, currently staff and faculty at Mayo Clinic Swathy Puthalapattu 2011 - 2013, currently faculty at Topeka VAMC Ahmed Khan 2011 - present, currently private practice, NYC, NY Sai Sunkara 2014 – present, currently PCCM Fellow iii. Endocrinology fellows mentored in research: Jeremy Anthony 2014 – present Tina Constantin 2014 – present iv. Internal Medicine (IM) Residents: Alexander Babeyuski (Atlanta Medical Center IM Resident), currently Hospitalist in Atlanta, GA - mentored in research, 2009-2010 v. Physician Assistant (PA) Students:

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Tom Murphy (PA Student), currently in practice in Atlanta - mentored clinically, 2009 vi. Medical Students: Kiley Kolb (currently IM Resident, Temple University, ) – mentored clinically, 2008 Monica Zhang (currently Ophthalmology Resident in Emory University) - mentored clinically, 2011 vii. Undergraduate Students: Cinan Lesley (Emory Undergraduate student, SIRE Program) – mentored in research, 2014 – present Robert Havranek (Emory Undergraduate student, SIRE Program) – mentored in research, 2014 - present viii. International Medical Students: Arman Qamar (India, New Delhi, currently IM Resident at University of Pennsylvania) - mentored in research, 2010-2011 ix. Postgraduate Trainees: Rina Eisenstein, MD (currently staff physician at the Atlanta VAMC) - mentored her clinically (2009-2011) to learn sleep medicine and to obtain sleep medicine board-certification on non-accredited, "grandfathered" track; since 2010 I have been mentoring Dr. Eisenstein academically (Geriatrics Hartford Research Award, mentor) Kandace McCarver (Sleep PA-C), Atlanta VAMC, mentored clinically and in research, 2011 - present Mary-Margaret Ciavatta (Sleep PA-C), Atlanta VAMC, mentored clinically and in research, 2011 – present Faye Routledge (Assistant Professor, Emory School of Nursing), mentored in research (project 'Cognitive Behavioral Therapy or Sleep Hygiene for Insomnia in Prehypertension and Hypertension'), 2013 – present Barry Fields (Assistant Professor, Emory School of Medicine, Atlanta VAMC Sleep Section), mentored in research (project 'START'), 2014 – present (current)

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25. Lectureships, Seminar Invitations, and Visiting Professorships: 1. Women Vet Fest, Atlanta VAMC, ”Sleep in Women Veterans”, November 2009 2. Emory University Internal Medicine Board Review – “Sleep Medicine”, 2009, 2010, 2011 3. Family Practice Board Review Course, “Pulmonary Medicine”, May and June 2010, February 2012 4. Atlanta VAMC (monthly conferences), “Smoking Cessation for Veterans”, 2009 – 2010 5. Georgia Association of Sleep Professionals (GASP) – Invited Conference, “Predictive Health in Sleep Medicine”, 2011 6. Pennsylvania State University – Hershey, PA, Visiting Professor, “Predictive Health in Sleep Medicine”, 2011 7. Atlanta Medical Center Grand Rounds, "Jet Lag", Atlanta, GA, 2012 8. Danbury Hospital Grand Rounds, "Sleep and Metabolic Syndrome", Danbury , CT, 2012 9. Georgia Association of Sleep Professionals (GASP) – Invited Conferences, “Obstructive Sleep Apnea and Metabolic Syndrome” and “Chronodisruption and Metabolic Syndrome”, 2012

26. Invitations to National and International Conferences: 1. “Jet Lag Syndrome” – Invited Conference at ACCP meeting ("CHEST"), Honolulu, HI, October 2011 2. “Physiology and Pulmonary Function Test” posters session, moderator, American College of Chest Physicians meeting (“CHEST”), Honolulu, HI, October, 2011 3. “Asthma Posters I” posters session, moderator, American College of Chest Physicians meeting (“CHEST”), Honolulu, HI, October, 2011 4. "Sleep and Aging" abstract reviewer, for American Academy of Sleep Medicine (AASM)/American Professional Sleep Societies (APSS) international meeting, Boston, MA, June 2012

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5. "Vasculitides", American College of Chest Physicians Board Review Course on Respiratory Pathology – invited conference, Phoenix, AZ, August 2012 6. "Pathology of Small Lung Samples", American College of Chest Physicians Board Review Course on Respiratory Pathology – invited conference, Phoenix, AZ, August 2012 7. American College of Chest Physicians (ACCP) Clinical Pulmonary Medicine Network Forum Featured Speaker – Octavian C. Ioachimescu, MD, PhD, "Volumetric analysis of pulmonary nodules: impact on clinical decisions in diagnosis and management", Atlanta, GA, October 2012 8. American College of Chest Physicians (ACCP) Clinical Pulmonary Medicine Network Plenary Session, "Obstructive Lung Disease (OLD) and OSA: A New Clinical Entity?”, CHEST meeting, Chicago, IL, October 2013 9. American College of Chest Physicians (ACCP) Session, “Sleep deprivation and shift work in post-training physicians”, CHEST meeting, Chicago, IL, October 2013 10. American College of Chest Physicians (ACCP) "Pulmonary Function and Rehabilitation" abstract reviewer, CHEST meeting, Chicago, IL, October 2013 11. American College of Chest Physicians (ACCP) "Critical Care Case Affiliate Reports I" abstract reviewer and moderator, CHEST meeting, Austin, TX, October 2014

27. Bibliography: Total: 27 PubMed indexed articles; >30 peer-reviewed publications Google Scholar (GS) citations: 535 ISI Thompson Reuters H Index: 6+

a. Published and Accepted Research Articles (clinical, basic science, other) in Referenced Journals: 1. Ioachimescu O.C., Ioachimescu A.G., Iannini P.B., 2004, “Severity Scoring in Pneumococcal CAP- a 5-year Experience” (Article, Clinical Investigation), International Journal of Antimicrobial Agents, 24: 485-490, PMID: 15519482 Citations: 31 (GS); 22 (PubMed)

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2. Ioachimescu O.C., Venkateshiah S. (first two authors contributed equally), McCarthy K., Kavuru M., Stoller J.K., 2005, “Estimating FVC from FEV2 and FEV3: Assessment of a Surrogate Spirometric Parameter” (Article, Clinical Investigation), Chest 128(3): 1274-1281, PMID: 16162718 Citations: 6 (GS); 3 (PubMed) 3. Venkateshiah S.B., Ioachimescu O.C. (first two authors contributed equally), McCarthy K., Stoller J.K., 2008, “The Utility of Spirometry in Diagnosing Pulmonary Restriction” (Article, Clinical Investigation), Lung, 186(1):19-25, PMID: 17990034 (first two authors contributed equally) Citations: 20 (GS); 10 (PubMed) 4. Koo BB, Dostal J, Ioachimescu O, Budur K., 2008, "The Effects of Gender and Age on REM-Related Sleep-Disordered Breathing" (Article, Clinical Investigation), Sleep Breath 12(3): 259-264, PMID: 18074161 Citations: 32 (GS); 19 (PubMed) 5. Puthalapattu S, Bhadriraju S, Roman-Rodriguez J, Perez R, Ioachimescu OC., 2013, Sleep Apnea and Other Sleep Disorders: Survey in Individuals with Idiopathic Pulmonary Fibrosis (IPF) (Article, Clinical Investigation), J Sleep Disorders Ther 2(3): 120-4 Link: http://www.omicsgroup.org/journals/2167-0277/2167-0277-2-120.pdf Citations: 1 (GS); 0 (PubMed) 6.

b. Manuscripts Submitted: 1. Ioachimescu O.C., McCarthy K., Stoller J.K. “Alternative Measurements in Spirometry: The Role of Area-Under-the-Expiratory Flow-Volume Curve” (Article, Clinical Investigation, submitted) 2. Ioachimescu O.C., Ciavatta M.M., McCarver K., "OLDOSA Syndrome" (Investigative Article, in submission) 3. Khatri S, Ioachimescu O.C., “The intersection between Obstructive Lung Diseases and Obstructive Sleep Apnea” (Review article, in review, CCJM) 4. Sunkara S., Ioachimescu O.C., “Sleep Disorders in COPD”, (Invited Review article,

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submitted, Sleeping and Breathing section of “Current Pulmonology Reports”). 5. Venkateshiah S, Ioachimescu O.C., “Restless Legs Syndrome” (Invited Review article, submitted, “Sleep and Circadian Rhythms in the ICU”) 6. Ioachimescu A.G., Ioachimescu O.C., “Hormones, endocrinopathies, sleep and sleep disorders” (submitted, Chapter in “Principles and Practice of Sleep Medicine, 2015, 6th edition – Kryger, Roth and Dement)

c. Review Articles: 1. Ioachimescu O., 1999, “Electrical Impedance Tomography, a New Imagistic Method?” Pneumologia 4: 301-303, PMID: 10856991 2. Ioachimescu O., 1999, “Considerations About Right Ventricular Function Assessment in Patients with COPD”, Pneumologia 2: 115-119, article awarded ‘The best article of the year 1999’. 3. Ioachimescu O.C., 2003, “Idiopathic Pulmonary Hemosiderosis in Adult”. (Review Article) Pneumologia, 52(1): 38-43, PMID: 14702700 Citations: 13 (GS); (PubMed) 4. Ioachimescu O.C., Sieber S., Kotch A.K., 2004, “Idiopathic Pulmonary Hemosiderosis Revisited” (Review Article), European Respiratory Journal, 24(1): 162-170, PMID: 15293620 Citations: 128 (GS); 45 (PubMed) 5. Ioachimescu O.C., Mehta A., 2005, “Bronchioloalveolar carcinoma and Adenocarcinoma of the Lung – a Morphogenetic Journey” Journal of Bronchology (Review Article), 12(3): 174-180 Citations: 4 (GS) 6. Ioachimescu O.C., Mehta A., 2005, “From Cystic Pulmonary Airway Malformation, to Bronchioloalveolar Carcinoma and Adenocarcinoma of the Lung” (Review Article), European Respiratory Journal 26(6): 1181-1187, PMID: 16319347 Citations: 53 (GS); 25 (PubMed) 7. Ioachimescu O.C., Kotch A., Stoller J. K., 2005, “Idiopathic pulmonary hemosiderosis in adults”. (Review Article). Clinical Pulmonary Medicine 12(1): 16-25 Citations: 5 (GS); (PubMed)

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8. Ioachimescu O.C., Stoller J.K., 2005, “A Review of Alpha-1 Antitrypsin Deficiency” (Review Article) Journal of Chronic Obstructive Pulmonary Disease, 2: 263-275, PMID: 17136953 Citations: 31 (GS); (PubMed) 9. Ioachimescu O.C., Kavuru M., 2006, “An Update on Pulmonary Alveolar Proteinosis” (Online Review Article), American College of Chest Physicians (ACCP) Pulmonary and Critical Care Update; Link: http://www.chestnet.org/education/online/pccu/vol20/lessons18_19/index.php 10. Ioachimescu O.C., Kavuru M., 2006, “Pulmonary Alveolar Proteinosis” (Review Article), Chron Respir Dis; 3(3): 149-159, PMID: 16916009 Citations: 95 (GS); (PubMed)) 11. Ioachimescu O.C., Corlan E., 2007, "New Data in Staging and Prognosis of Bronchopulmonary Carcinoma. Part I: Epidemiology and Diagnostic Procedures" (Review Article), Pneumologia 56(3): 129-136, PMID: 18019973 12. Ioachimescu O.C., Corlan E., 2008, "New Data in Staging and Prognosis of Bronchopulmonary Carcinoma. Part II – Lung Nodule Volumetric Analysis" (Review Article), Pneumologia 57(4): 209-220, PMID: 19186683 13. Ioachimescu O.C., Stoller J.K., 2008, “Diffuse Alveolar Hemorrhage – diagnosing it and finding the cause” (Review Article), Cleve Clin J Med, 78: 258-270, PMID: 18491433 Citations: 84 (GS); 26 (PubMed) 14. Ioachimescu O.C., El Solh, A.l., Jun 2012, "Pharmacotherapy of insomnia " (Invited Review), Expert Opin Pharmacother. 13(9):1243-60. Epub 2012 May 11, PMID: 22578014 Citations: 7 (GS); 4 (PubMed) 15. Ioachimescu O.C., Collop N., Nov 2012, "Sleep Disordered Breathing" (invited chapter/review in "Sleep Disorders" issue) Neurologic Clinics 30: 1095-1136, PMID: 23099131; Link: http://dx.doi.org/10.1016/j.ncl.2012.08.003 Citations: 4 (GS); 1 (PubMed) 16. Ioachimescu O.C., Teodorescu M., “Integrating the Overlap between Obstructive Lung Disorders and Obstructive Sleep Apnea: OLDOSA Syndrome” (Invited Review

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Article), Respirology. 2013 Apr;18(3):421-31, PMID: 23368952 Citations: 6 (GS); 1 (PubMed) 17. Ioachimescu O.C., “On Obstructive Lung Disease and Obstructive Sleep Apnea: Time to Revisit Nosologies?” (Invited Perspective Article), Chest Physician, 2013 Jun; 8(6):22. Citations: 0 18. Puthalapattu S, Ioachimescu O.C., "Asthma and Obstructive Sleep Apnea: Clinical and Pathogenic Interactions" (Review), J Investig Med. 2014 Apr; 62(4):665-75, PMID: 24583902 Citations: 0 19. Ioachimescu O.C. et al. “A dozen years of American Academy of Sleep Medicine (AASM) International Mini-Fellowship: program evaluation and future directions” (Perspective article), J Clin Sleep Med. 2014 Mar 15; 10(3):331-4, PMID: 24634633 Citations: 0

d. Symposium Contributions (abstracts, posters): 1. Corlan D., Vinereanu D., Ioachimescu O., Gherasim L., 1997, “Computer Simulation of In Vivo AV Node Pacing Experiments with Coverage of Whole Parameter Space”, (Abstract, Clinical Investigation), August 1997, Stockholm, Sweden, European Heart Journal, vol 18, Abstract Supplement; Link: http://clarrhmos.corlan.net/publ.html 2. Ioachimescu O., Ioachimescu A., Galbenu P., Cilt C., Stoicescu P.I., Bogdan M.A., 1998, “Does Endocrine Semiology Means Endocrinopathy? - Case Presentations”, (Abstract, case report), , The 8th National Symposium of PsychoNeuroEndocrinology, June 1998, Sibiu, Romania, published in “Revue Roumaine d’Endocrinologie” vol 3- 4/1998 3. Ioachimescu O., Stoicescu P.I., 1999, “A Proposal for a National Registry of Histiocytosis X”, (Abstract, Clinical Investigation), National Congress of Pulmonology, Poiana Brasov, October 1999, Pneumologia 3:221 4. Ioachimescu O., Serbescu A., 1999, “Histiocytosis X with Multiple Determinations, Case Presentation”, (Abstract, case report), National Congress of Pulmonology, Poiana Brasov, October 1999, Pneumologia 3:221

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5. Ioachimescu O.C., Sieber S., Walker M., Rella V., Kotch A., 2001, “Bronchial- Associated Lymphoid Tissue Lymphoma”, (Abstract, case report), ACP CT Meeting, Joseph Belsky Research Day, 3rd prize, May 2001, published in Connecticut Medicine, vol 65(9) 6. Ioachimescu O.C., Salamon C., Iannini P.B., 2001, “Risk Stratification in Pneumococcal Community Acquired Pneumonia: a Retrospective Analysis”, (Abstract, Clinical Investigation), Joseph Belsky Research Day, September 2001, published in Connecticut Medicine, vol 65(9) 7. Ioachimescu O., Stoicescu P.I., 2001, “Langerhans Cell Histiocytosis”. Joseph Belsky Research Day, 2nd Prize, May 2001, (Abstract, case report), published in “Connecticut Medicine”, vol 65(9) 8. Ioachimescu O.C., Ioachimescu A.G., Iannini P.B., 2002, “Clinical Outcome in Pneumococcal Pneumonia at Danbury Hopital”, (Abstract, Clinical Investigation), Joseph Belsky Research Day, May 2002, published in Connecticut Medicine, vol. 66(12) 9. Ioachimescu O.C., Ioachimescu A.G., Iannini P.B., 2003, “Pneumococcal CAP – Severity Scoring Aftermath”, (Abstract, Clinical Investigation), First International Congress on CAP, Windsor, Canada, Sept 2003 10. Ioachimescu O., Sieber S., Kotch A., 2003, “SZ Phenotype, ANCA, and More”, (Abstract, case report), American Thoracic Society, Alpha-1 Foundation Meeting, Seattle, May 2003. 11. Ioachimescu O.C., Nee P., Prince M., Karlin R., Gupta S., 2003, “Gastroparesis in Dengue Fever: First Report”, (Abstract, case report), Joseph Belsky Research Day, May 2003 12. Ioachimescu O., Charti A., DeCamp M., Mehta A., 2004, “Delayed Treatment of Bronchial Stenosis”, (Abstract, case report), International Congress of Bronchology, Barcelona, Spain, June 2004 13. Ioachimescu O.C., Lamont J., Bae C., Foldvary-Schaefer N., Golish J., 2005, “Determinants of the Ideal Level of Continuous Positive Airway Pressure in Obstructive Sleep Apnea”, (Abstract, Clinical Investigation), American College of Chest Physicians

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(ACCP), Montreal, Canada, Nov 2005; Link: http://meeting.chestjournal.org/cgi/content/abstract/128/4/233S 14. Ioachimescu O.C., McCarthy K., Kavuru M., Stoller, J.K., 2005, “A Logarithmic Model

of Predicting FVC Bbased on FEV1, FEV2, and FEV3 “ (Clinical Investigation), American College of Chest Physicians (ACCP), Montreal, Canada, Nov 2005; Link: http://meeting.chestjournal.org/cgi/content/abstract/128/4/173S Citations: 1 15. Budur K., Bae C., Foldvary-Schaefer N., Ioachimescu O., 2005, “The Correlation Between Epworth Sleepiness Scale Score and Driving Accidents: a Retrospective Analysis of 150 Cases” (Abstract, Clinical Investigation), Associated Professional Sleep Societies (APSS), Denver, June 2005, SLEEP, Volume 28, Abstract Supplement: A350; Link: www.journalsleep.org/PDF/AbstractBook2005.pdf 16. Ioachimescu O.C., Bedford T., Bae C., Foldvary-Schaefer N., Aboussouan L., Golish J., 2006, “Continuous Positive Airway Pressure (CPAP) Level in Obstructive Sleep Apnea (OSA): the Aftermath of Various Mathematical Models” (Abstract, Clinical Investigation), Associated Professional Sleep Societies (APSS), Salt Lake City, June 2006, SLEEP, Volume 29, Abstract Supplement, 2006: A203; Link: http://www.journalsleep.org/PDF/AbstractBook2006.pdf 17. Koo B., Budur K., Ioachimescu O., 2006, “Demographic and Polysomnographic Characteristics in Patients with REM-Related Obstructive Sleep Apnea: A Retrospective Analysis of 226 Patients” (Abstract, Clinical Investigation), Associated Professional Sleep Societies (APSS), Salt Lake City, October 2006, SLEEP, Volume 29, Abstract Supplement: A191; Link: http://www.journalsleep.org/PDF/AbstractBook2006.pdf 18. Bae C., Schauer P., Chand B., Ioachimescu O., Foldvary-Schaefer N., 2006, “Clinical and Polysomnographic Features of Bariatric Surgery Candidates with Suspected Sleep Apnea” (Abstract, Clinical Investigation), Associated Professional Sleep Societies (APSS), Salt Lake City, June 2006, SLEEP, Volume 29, Abstract Supplement: A215; Link: http://www.journalsleep.org/PDF/AbstractBook2006.pdf 19. Linarez E., Budur K., Stephenson L., Ioachimescu O., Foldvary-Schaefer, N., 2007, “Sleep Related Breathing Disorder In Heart Failure Patients: A Retrospective Study Of

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Sixty Patients” (Abstract, Clinical Investigation), (Abstract, Clinical Investigation), Associated Professional Sleep Societies (APSS), Minneapolis, June 2007, SLEEP, Volume 30, Abstract Supplement: A170; Link: http://www.journalsleep.org/PDF/AbstractBook2007.pdf 20. McWhirter D., Bae C., Ioachimescu O., 2007, “Can Split Night Polysomnograms be Improved by Using an Algorithm to Predict the Starting CPAP?” (Abstract, Clinical Investigation), Minneapolis, June 2007, (Abstract, Clinical Investigation), Associated Professional Sleep Societies (APSS), Minneapolis, June 2007, SLEEP, Volume 30, Abstract Supplement, 2007: A174; Link: http://www.journalsleep.org/PDF/AbstractBook2007.pdf 21. Talih F., Budur K., Ioachimescu O., Foldvary-Schaefer N., 2007, “Measuring Insomnia with the Insomnia Severity Index in Epilepsy Patients”. (Abstract, Clinical Investigation), (Abstract, Clinical Investigation), Associated Professional Sleep Societies (APSS), Minneapolis, June 2007, SLEEP, Volume 30, Abstract Supplement: A249; Link: http://www.journalsleep.org/PDF/AbstractBook2007.pdf 22. Bae C., Ioachimescu O., Schauer P., Chand B., 2007, “Physical Examination Predictors of Obstructive Sleep Apnea in Bariatric Surgery Candidates”(Abstract, Clinical Investigation), (Abstract, Clinical Investigation), Associated Professional Sleep Societies (APSS), Minneapolis, June 2007, SLEEP, Volume 30, Abstract Supplement: A207; Link: http://www.journalsleep.org/PDF/AbstractBook2007.pdf Citations: 1 (GS); 1 (PubMed) 23. Ioachimescu O, Bedford T, Stephenson L, Foldvary-Schaefer N, Golish J., 2007, "The Diagnosis and Severity of Obstructive Sleep Apnea (OSA): a Comprehensive Analysis of Different Predictive Models” (Abstract, Clinical Investigation), Associated Professional Sleep Societies (APSS), Minneapolis, June 2007, SLEEP, Volume 30, Abstract Supplement: A165; Link: http://www.journalsleep.org/PDF/AbstractBook2007.pdf Citations: 0 (GS); 1 (PubMed) 24. Ioachimescu O.C., Bedford T, Stephenson L., Foldvary-Schaefer N., Golish J., 2007, “A Large Cohort Validation of CPAP Setting Predictions Based on Demographic,

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Anthropometric and Polysomnographic Data”(Abstract, Clinical Investigation), ATS, San Francisco, May 2007, AJRCCM 175: A708 25. Budur K, Sliwinski J, Mermigkis H, Novak W, Ioachimescu O., 2008, "Biofeedback for Psychophysiological Insomnia: Analysis of Patient and Treatment Characteristics in 30 Patients" (Abstract, Clinical Investigation), Associated Professional Sleep Societies (APSS), Baltimore, June 2008, SLEEP 31:A234, Abstract Supplement; Link: http://www.journalsleep.org/PDF/AbstractBook2008.pdf 26. Ioachimescu O., McCarthy K, Stoller JK., 2008, "Alternative Spirometric Measurements of Obstruction: Area-Under-Expiratory-Flow-Volume Curve", Emory University School of Medicine 1st Faculty Research Day, June, 2008, (Abstract, Clinical Investigation) 27. Ioachimescu O.C., Bedford T., 2010, “Aftermath of Optimal CPAP Prediction Models using Various Linear, Logistic Regression and Artificial Neural Networks (ANN) in OSA” (Abstract, Clinical Investigation) European Respiratory Society Annual Congress, Barcelona, Spain, September 2010; Link: http://www.ersnet.org/learning_resources_player/abstract_print_10/main_frameset.htm 28. Puthalapattu S., Baqir M., Ioachimescu O.C., 2012, "Evaluation of Several Spirometric Predictive Equations in a Cohort of 951 Veterans", Southern Society of Clinical Investigation, New Orleans, February 2012; published in: Journal of Investigative Medicine Volume: 60 (1): 453-454, 2012 29. Ioachimescu O.C, Ciavatta MM, McCarver K, Anderson A, Tanukonda V, 2014, “Asthma, COPD and overlap syndrome in a cohort of veterans”, American Thoracic Society (ATS) meeting, San Diego, May 2014 (Abstract, Clinical Investigation); published in American Journal of Respiratory and Critical Care Medicine (AJRCCM) 189:A5846; Link: http://www.atsjournals.org/doi/abs/10.1164/ajrccm- conference.2014.189.1_MeetingAbstracts.A5846 30.

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e. Book Chapters: 1. Coculescu M., Ioachimescu O., Ciobanu R., 2003, “Endocrine Diseases and the Cardiovascular System”. Chapter in: ‘Textbook of Cardiology’, Costin Carp, Ed. Medicala Nationala, pp. 1071-97 2. Ioachimescu O.C., Tomford W. “Tuberculosis”, 2004, Chapter in ‘Disease Management Project’, Cleveland Clinic Foundation; Link: http://www.clevelandclinicmeded.com/diseasemanagement/pulmonary/tb/tb.htm 3. Ioachimescu O.C., 2006, “Idiopathic Pulmonary Hemosiderosis” – Chapter in Encyclopedia of Respiratory Medicine, Editors: Geoffrey J. Laurent and Steven D. Shapiro, © 2006 Elsevier Ltd, ISBN (Set): 0-12-438360-2, Winner of the Best Multi- Volume Reference Work (Science), 2006 Professional/Scholarly Publishing Division of the Association of American Publishers (AAP) 4. Ioachimescu O.C., 2006, “Diffuse Alveolar Hemorrhage Syndrome” – Chapter in Encyclopedia of Respiratory Medicine, Editors: Geoffrey J. Laurent and Steven D. Shapiro, © 2006 Elsevier Ltd, ISBN (Set): 0-12-438360-2, Winner of the Best Multi- Volume Reference Work (Science), 2006 Professional/Scholarly Publishing Division of the Association of American Publishers (AAP) Citations: 5 (GS); (PubMed) 5. Ioachimescu O.C., 2006, “Autoantibodies in Lung Disease” – Chapter in Encyclopedia of Respiratory Medicine, Editors: Geoffrey J. Laurent and Steven D. Shapiro, © 2006 Elsevier Ltd, ISBN (Set): 0-12-438360-2, Winner of the Best Multi-Volume Reference Work (Science), 2006 Professional/Scholarly Publishing Division of the Association of American Publishers (AAP) Citations: 3 (GS); (PubMed) 6. Ioachimescu O.C. (Prof Corlan E., Coordinator) "Staging and Outcome in Lung Cancer – Volumetric Analysis of Pulmonary Nodules", PhD thesis, Carol Davila University, Bucharest, Romania, March 2008; Link: http://www.univermed- cdgm.ro/dwl/teze_doct/2008_med_Octavian_Ioachimescu.pdf 7. Ioachimescu O.C., Tomford W. “Non-tuberculous Mycobacteria”, 2009, Chapter in: Current Clinical Medicine, by William D. Carey; Link: http://www.us.elsevierhealth.com/product.jsp?isbn=9781416040965

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8. Ioachimescu O.C., 2008, revised 2009, 2010, 2011, 2012, 2013, “Narcolepsy”, BMJ Point of Care/Epocrates (Online Chapter); Link: https://online.epocrates.com/dx/full.do?Type=1&MonographId=428

f. Books Edited and Written: Editor of "Contemporary Sleep Medicine", first electronic sleep textbook, October 2011 (Bentham Publishing) Physician version: http://www.benthamscience.com/ebooks/9781608051533/index.htm Patient version: http://www.benthamscience.com/ebooks/9781608052677/index.htm

g. Book Reviews: 1. Ioachimescu O.C., 2004, “Lung Alert: Cytokine Receptors and Fibroblast Proliferation in Interstitial Pneumonia” (Article Review), Thorax, 59:760; Link: http://thorax.bmjjournals.com/cgi/content/full/59/9/760 2. Ioachimescu O.C., 2006, “Manual of Intensive Care Medicine, 4th Edition, Richard S. Irwin and James M. Rippe, editors (Spiral edition), softcover, illustrated, 920 pages. Philadelphia: Lippincott Williams & Wilkins/Wolters Kluwer" (Book Review), Respiratory Care, Sept. 2006 3. Ioachimescu O.C., 2006, “Interpreting Chest X-Rays: Illustrated with 100 cases. Philip Eng and Foong-Koon Cheah” (Book Review), Respiratory Care 51(2):188 4. Golish J, Ioachimescu O.C., 2007, "Ambulatory Titration of Continuous Positive Airway Pressure was as Effective as Polysomnography for Obstructive Sleep Apnoea", Evid Based Med;12(5): 148, PMID: 17909239 5. Golish J., Ioachimescu O.C., 2007, "Mulgrew et al. On the Value of a Diagnostic Algorithm in Diagnosing and Treating OSA" (Article review), American College of Physicians (ACP) Journal Club, vol 147 (2), PMID: 17764136 6. Ioachimescu, O.C., 2011, "Fruit Soup or Fruity Chowder? [A Blog as an Octalogue]", Pulmonary Central (Online Publication); Link: http://www.pulmonarycentral.org/feburary- 2011-literature-roundup 7. Ioachimescu, O.C., 2013, "On Obstructive Lung Disease and Obstructive Sleep Apnea: Time to Revisit Nosologies?", Chest Physician, June 2013

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h. Other Publications (Case Reports): 1. Ioachimescu O., Stoian S., Stoicescu I.P., 2000, “Histiocytosis X, an Old and Re-opened X File?” (Case report and review of the literature), Rev Roum Med Int 3 2. Ioachimescu O.C., Sieber S., Rella V., Walker M., Kotch A., 2002 “A 35-Year-Old Woman with Asthma and Polycystic Lung Disease”, Clinical Pearl/Case Presentation, Chest,121: 256-260, PMID: 11796459 Citations: 4 (GS); 4 (PubMed) 3. Ioachimescu O.C., Farver C., Stoller J. K., 2005, “Hemoptysis in a 77 Year-Old Male with a Systolic Murmur” (Clinical Pearl/Case Presentation), Chest 128(2):1022-1027, PMID: 16100202 Citations: 2 (GS); 1 (PubMed) 4. Ioachimescu O.C., Stoller J.K., 2006, “EctoPICC” (Medical Image), Cleve Clin J Med 73(7): 617-618, PMID: 16845973 Citations: 4 (GS); (PubMed) 5. Ioachimescu O.C., Stoller J.K., 2006, “A Middle-Aged Woman with Chronic Liver Disease and Shortness of Breath” (Case report and review of the literature on Hepato-pulmonary Syndrome), Cleve Clin J Med 73(4): 375-389, PMID: 16610398 6. Ioachimescu O.C., Jennings C., 2006, “Lung Cyst Herniation” (Medical Image), Mayo Clin Proc 81(5): 692, PMID: 16706267 7. Ioachimescu O.C., Mehta A., Stoller J.K., 2007, “Hepatopulmonary Syndrome Following Portopulmonary Hypertension” (Case Report and Review of the Literature), Eur Respir J 29: 1277–1280, PMID: 17540789; Link: www.erj.ersjournals.com/cgi/reprint/29/6/1277.pdf Citations: 15 (GS); (PubMed) 8. Baqir M, Ioachimescu O., 2011, "A Case of Recent Hemoptysis Postcardiac Surgery (ACCP Online Case Puzzler); Link: http://www.chestnet.org/accp/case-puzzlers/clinical-pulmonary-medicine-network-puzzler- march-2011-0 9. Puthalapattu S., Udoji, T., Ioachimescu O.C., 2012, “Dyspnea in a Patient With Mounier- Kuhn Syndrome" (Case Report), J Bronchol Intervent Pulmonol, 19(2): 145-148, PMID: 23207360

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10. Baqir M, Ioachimescu O.C., 2012, “A Transsexual with Acute Dyspnea and Diffuse Infiltrates” (Case Report, ATS Online Puzzler), link: http://www.thoracic.org/clinical/ats- clinical-cases/pages/11-12.php

i. Oral Communications: 1. Ioachimescu O.C., Radoi M., Campeanu A., Vann Jones J., 1995, “Angiotensin Converting Enzyme Inhibitors and Beta-Blockers in the Treatment of Acute Myocardial Infarction”, Bucharest, Romania (Diploma Thesis, Clinical Investigation) 2. Ioachimescu O.C., 1996. “Beta blockers and ACE inhibitors in the treatment of 40 patients with acute myocardial infarction in Bristol Royal Infirmary”, Session of Scientific Society of Medical Students, Bucharest, Romania (Clinical Investigation) 3. Ioachimescu O., 1997, “Endothelial Dysfunction in Hypertension”, Symposium “Arterial Hypertension, State of the Art”, Sinaia, Romania 4. Ioachimescu O.C., 2001, “Veno-Thromboembolic Disease: Prophylaxis in 2001”, Danbury Hospital, Danbury, CT 5. Ioachimescu O., 2001, “Harvard Pulmonary Grand Rounds: An Interesting Case”, Massachusetts General Hospital, Boston, MA (Case Report) 6. Ioachimescu O.C., 2000-2003, “Morbidity and Mortality Conference”, Danbury Hospital, Danbury, CT (Case Reports) 7. Ioachimescu O.C., 2003, “SZ phenotype, ANCA and More”, Joseph Belsky Research Day, Danbury, CT (Case Report) 8. Ioachimescu O.C., 2005, “CPAP Titration”, Sleep Technologists’ Day, Cleveland Clinic, Cleveland, OH 9. Ioachimescu O.C., 2005, “Research in Progress: Volumetric Analysis of Pulmonary Nodules”, Cleveland Clinic, Cleveland, OH (Clinical Investigation) 10. Ioachimescu O.C., 2005, “Determinants of the ideal level of continuous positive airway pressure in obstructive sleep apnea”, (Clinical Investigation), 30th Annual NeuroScience Day, Cleveland Clinic, Cleveland, OH 11. Ioachimescu O.C., 2005, McCarthy K., Kavuru M., Stoller J.K. “A logarithmic model of

predicting FVC based on FEV1, FEV2, and FEV3“, ACCP, Montreal, Canada (Clinical Investigation)

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12. Ioachimescu O.C., 2006, “Algorithmic Diagnosis of OSA and CPAP prescription”, Lung Summit 2006, Cleveland Clinic, Cleveland, OH (Clinical Investigation) 13. Ioachimescu O.C., 2006, “Spirometry” – IM Residents Grand Rounds, Cleveland Clinic, Cleveland, OH 14. Ioachimescu O.C., 2006, “Alternative Measurements to Aid Interpretation of Spirometry: The Role of Area-Under-the-Expiratory Flow-Volume Curve”, American College of Chest Physicians, Salt Lake City, UT (Clinical Investigation) 15. Ioachimescu O., 2007, “Vagal Nerve Stimulators and Obstructive Sleep Apnea”, Cleveland Clinic Multidisciplinary Rounds, Cleveland, OH 16. Ioachimescu O.C., 2007, “The Diagnosis and Severity of OSA: a Comprehensive Analysis of Different Predictive Models” – Neuroscience Day, Cleveland Clinic, 3rd Prize Research Award, (Clinical Investigation) 17. Ioachimescu O., 2007, “Vagal Nerve Stimulators and Obstructive Sleep Apnea”, Cleveland Clinic Sleep Technologists’ Lecture, Cleveland, OH 18. Ioachimescu O.C., Bedford T, Stephenson L., Foldvary-Schaefer N., Golish J., 2007, “The Diagnosis and Severity of Obstructive Sleep Apnea (OSA): a Comprehensive Analysis of Different Predictive Models”, APSS, Minneapolis, Sleep 30(Suppl): A165 (Clinical Investigation) Citations: 1 (GS); (PubMed) 19. Ioachimescu O.C., 2008, "Hypersomnia Syndromes", Pulmonary and Critical Care Fellows’ Conference, Emory University 20. Ioachimescu O.C., 2008, "The Sleepy Patient", Pulmonary and Critical Care Fellows’ Conference, Emory University 21. Ioachimescu O.C., 2008, "VA Sleep Soup", Pulmonary and Critical Care Fellows’ Conference, Atlanta VAMC 22. Ioachimescu O.C., 2008, "Staging and Outcome in Lung Cancer – Volumetric Analysis of Pulmonary Nodules", Carol Davila University, Bucharest, Romania (PhD Thesis Dissertation) 23. Ioachimescu O.C., 2008, "Sleep Medicine Topics for Internal Medicine Providers", Noon Conference for IM Residents, Emory University – VAMC

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24. Ioachimescu O.C., 2007-2009, "Atlanta Citywide Sleep Journal Club", monthly meeting (organizer and speaker) 25. Ioachimescu O.C., 2009, "Great New Medicine: Idealol", Emory University School of Medicine Junior Faculty Development Course 26. Ioachimescu O.C., 2009, “Women Veterans and Sleep: An Overview”, Atlanta VAMC, Women Vet Fest– invited conference 27. Ioachimescu O.C., 2008, "Sleep Medicine for Primary Care Providers", Grand Rounds for Primary Care Department, Atlanta VAMC 28. Ioachimescu, O.C., March 2009, "Pathogenesis and Diagnostic Evaluation of Sleep Disordered Breathing", Atlanta School of Sleep Board Review course 29. Ioachimescu, O.C., March and October 2009, "Treatment of Sleep Disordered Breathing", Atlanta School of Sleep Board Review course 30. Ioachimescu, O.C., October 2009, "Preparing for the Exam", Atlanta School of Sleep Board Review course 31. Ioachimescu, O.C., October 2009, "Physiological Aspects of Sleep and Breathing", Atlanta School of Sleep Board Review course 32. Ioachimescu O.C., 2009, 2010, 2011, “Sleep Medicine”, Emory University Internal Medicine Board Review 33. Ioachimescu O.C., May and June 2009, “Pulmonary Medicine”, Family Practice Board Review Course 34. Ioachimescu O.C., monthly 2009 – 2010, “Smoking Cessation for Veterans”, Atlanta VAMC 35. Ioachimescu O.C., 2009, “General Sleep Medicine”, Pulmonary /Critical Care Medicine Fellows Conference, Emory University 36. Ioachimescu O.C., 2009, “Hypersomnias for Pulmonologists”, Pulmonary /Critical Care Medicine Fellows Conference, Emory University 37. Ioachimescu O.C., 2009, “Pulmonary Diagnostics”, IM Residents Conference, Emory University 38. Ioachimescu O.C., 2008-2011, “Ventilator Waveforms”, IM Residents - MICU Conference, Atlanta VAMC

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39. Ioachimescu O.C., 2008-2011, “ABG Interpretation”, IM Residents - MICU Conference, Atlanta VAMC 40. Ioachimescu O.C., 2008-2011, “Mechanical Ventilation”, IM Residents - MICU Conference, Atlanta VAMC 41. Ioachimescu O.C., 2008-2011, “About BNP: What Every Resident In MICU Needs to Know About This”, IM Residents - MICU Conference, Atlanta VAMC 42. Ioachimescu O.C., 2008-2011, “Acute Respiratory Failure - Pathophysiology”, IM Residents - MICU Conference, Atlanta VAMC 43. Ioachimescu O.C., 2010, “Chronic Obstructive Pulmonary Disease – Palliative and End- of-Life Issues”, Palliative Care and Hospice Medicine Fellows Conference, Emory University 44. Ioachimescu O.C., 2010, 2012 “Alveolar Hemorrhage Syndromes”, Pulmonary /Critical Care Medicine Fellows Conference, Emory University 45. Ioachimescu O.C., 2011, “Pulmonary Function Testing: Spirometry”, IM Residents Conference, Emory University 46. Ioachimescu O.C., May 2011, “Predictive Health in Sleep Medicine” – GA Association of Sleep Professionals (GASP) – invited conference 47. Ioachimescu O.C., September 2011, “Predictive Health in Sleep Medicine”, Pennsylvania State University, Hershey, PA – invited conference 48. Ioachimescu O.C., October 2011, “Jet Lag Syndrome” – ACCP annual meeting (“CHEST”), Honolulu, HI – invited faculty 49. Ioachimescu, O.C., February 2012, "Sleep Disordered Breathing" (30-minute presentation for Perianesthesia VAMC Sleep Journal Club), 2012 50. Ioachimescu O.C., February 2012, "Sleep Cycles and Debt", Emory University College Freshman lecture – invited conference 51. Ioachimescu O.C., February 2012, "Citywide Sleep Journal Club – Three Recent Articles on Jet Lag", Atlanta VAMC 52. Ioachimescu O.C., February 2012, "Pulmonary Board Review", Education Consultants Inc (CME), 4-hour conference, Atlanta, GA 53. Ioachimescu O.C., March 2012, "Jet Lag Syndrome", Atlanta Medical Center Grand Rounds for IM Residents – invited conference

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54. Ioachimescu O.C., April 2012, “Chronodisruption and Metabolic Syndrome” – GA Association of Sleep Professionals (GASP) – invited conference 55. Ioachimescu O.C., April 2012, “Obstructive Sleep Apnea and Metabolic Syndrome” – GA Association of Sleep Professionals (GASP) – invited conference 56. Ioachimescu O.C., May 2012, "Sleep and Metabolic Syndrome", Danbury Hospital, Danbury , CT 57. Ioachimescu O.C., May 2012, "Hypersomnia and Parasomnia Syndromes", Emory University Pulmonary Fellowship core conference 58. Ioachimescu O.C., June 2012, "Palliative Care in COPD", Emory University, Palliative Care Fellowship core conference 59. Ioachimescu O.C., August 2012, "Physiology of Sleep (Respiratory/Cardiovascular)", Emory University, Sleep Medicine Fellowship core conference 60. Ioachimescu O.C., August 2012, "Vasculitides", American College of Chest Physicians Board Review Course on Respiratory Pathology – invited conference 61. Ioachimescu O.C., August 2012, "Pathology of Small Lung Samples", American College of Chest Physicians Board Review Course on Respiratory Pathology – invited conference 62. Ioachimescu O.C., September 2012, "Obstructive Sleep Apnea -- Pathophysiology and Evaluation", Emory University, Sleep Medicine Fellowship core conference 63. Ioachimescu O.C., October 2012, "Clinical and Radiological Characteristics of Pulmonary Nodules as Clinical Predictors of Lung Cancer", American College of Chest Physicians (ACCP) international meeting, Atlanta, GA – invited conference 64. Ioachimescu O.C., October 2012, American College of Chest Physicians (ACCP) Clinical Pulmonary Medicine Network Forum Featured Speaker, "Volumetric analysis of pulmonary nodules: impact on clinical decisions in diagnosis and management" – invited conference 65. Ioachimescu O.C., February 2013 , Emory University School of Medicine, M1 Pulmonary Module, "Respiratory Gas Exchange" 66. Ioachimescu O.C., May 2013, Atlanta VA Advanced Practice Conference, "Sleep Medicine for Non-Sleep Specialists" 67. Ioachimescu O.C., August 2013, "Physiology of Sleep (Respiratory/Cardiovascular)", Emory University, Sleep Medicine Fellowship core conference

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68. Ioachimescu O.C., October 2013, "Obstructive Sleep Apnea -- Pathophysiology and Evaluation", Emory University, Sleep Medicine Fellowship core conference 69. Ioachimescu O.C., October 2013, American College of Chest Physicians (ACCP) Clinical Pulmonary Medicine Network Plenary Session, CHEST meeting, Chicago, IL, "Obstructive Lung Disease (OLD) and OSA: A New Clinical Entity?" 70. Ioachimescu, O.C., October 2013, American College of Chest Physicians (ACCP), CHEST meeting, Chicago, IL, "Sleep Deprivation and Shift Work Disorder in Post-Training Physicians" 71. Ioachimescu O.C., February 2014, Emory University School of Medicine, M1 Pulmonary Module, "Respiratory Gas Exchange" 72. Ioachimescu O.C., April 2014, Emory University Department of Medicine Grand Rounds, “A New View on Obstructive Lung and Airway Disorders” 73. Ioachimescu O.C., June 2014, Emory University Department of Medicine Noon Conference for Residents, “Sleep Medicine for Non-Sleep Providers” 74. Ioachimescu O.C., July 2014, Pulmonary Citywide Conference, “An Old Case of Idiopathic Pulmonary Hemosiderosis” 75. Ioachimescu O.C., August 2014, "Physiology of Sleep (Respiratory/Cardiovascular)", Emory University, Sleep Medicine Fellowship core conference 76. Ioachimescu O.C., November 2014, “Sleepy patients”, Pulmonary /Critical Care Medicine Fellows Conference, Emory University 77. Ioachimescu O.C., November 2014, Emory University Department of Medicine Core Conference for IM Residents, “Sleep Medicine for Internal Medicine Providers” 78.

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