Influence of Chronic Recurrent Multifocal Osteomyelitis (CRMO) on Densitometry Measurements Obtained by Dual X-Ray Absorptiometry
r Biomar ula ke c rs Costantini et al., J Mol Biomark Diagn 2017, 8:4 le o & M D f i DOI: 10.4172/2155-9929.1000341 a o g l Journal of Molecular Biomarkers n a o n r s i u s o J ISSN: 2155-9929 & Diagnosis Research Artilce Open Access Influence of Chronic Recurrent Multifocal Osteomyelitis (CRMO) On Densitometry Measurements Obtained by Dual X-Ray Absorptiometry Danny L Costantini1,3*, Reza Vali1,3, Eman Marie1,3, Mandy Kohli1, Holly Convery2, Martin Charron5, Amer Shammas1,3 and Ronald M Laxer2,4 1Department of Medical Imaging, The Hospital for Sick Children, Toronto, Canada 2Division of Rheumatology, Hospital for Sick Children, Toronto, Canada 3Department of Medical Imaging, University of Toronto, Toronto, Canada 4Department of Pediatrics, University of Toronto, Toronto, Canada 5Brampton Nuclear Services, Brampton, Canada Abstract The incidence of detecting focal chronic recurrent multifocal osteomyelitis (CRMO) lesions on dual-energy x-ray absorptiometry (DXA), and the effect of these lesions on DXA bone mineral density (BMD), bone mineral content (BMC), and their associated Z-scores were retrospectively reviewed. Materials and Methods. The study included 22 patients (14 females, 8 males; median age of 13 years) with CRMO and in whom a total body less head (TBLH) and lumbar spine DXA scan had been obtained. Whole-body bone scintigraphy and MRI were used as the reference standards. Sites involved with CRMO were subsequently detected and DXA measurements were re-measured after removing the sclerotic lesions from the analysis. Results. In total, sclerotic CRMO lesions were detected in 15 of the 22 patients (68%) by DXA, although the number of lesions detected (on a per-lesion analysis) was much less (i.e.
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