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ISSX President's Message Volume 40 Issue 4, 2017 ISSX President’s Message By Geoff Tucker, ISSX President The North American Meeting in or European regions were successful Finally, the time Providence, Rhode Island at the in the last round of elections. This for me to step end of September attracted 630 may reflect the current make-up of down as attendees, and Meeting Chairs ISSX membership, being 61% from President is Jash Unadkat and Alan Rettie are to North America and 19% from both approaching be congratulated on their excellent Asia Pacific and Europe, and is rapidly. In organization of a well-balanced clearly not sustainable for an Providence I program. For me, a highlight of international society. Accordingly, already passed the meeting was the outstanding Council agreed that the by-laws the chain of Geoff Tucker, Ph.D. presentations by the recipients should be modified to rectify the office (a rather ISSX President. of the North American Scientific situation. How exactly to assure attractive Achievement Awards, Kathy global representation is under accessory engraved with the names Giacomini and Namandje Bumpus. discussion and, in due course, of all previous Presidents that Steve members will be asked to ratify a Kemp keeps under lock and key) A face-to-face meeting of Council proposed change to the statutes. to my successor, Tom Baillie. in Providence allowed time for a Serving ISSX in the role of President reflective and productive discussion Meanwhile, programming plans for over the last two years has been on strategic issues, with focus the upcoming 2018 meetings in an interesting and enjoyable particularly on membership benefits, Montreal and China are proceeding experience. For that I have to thank conference programing, and Council apace, and further webinars are my fellow Council members for their structure and function. Expect to planned. The most recent webinar continued support and, of course, see outcomes in terms of action was presented on October 26 by Phil Steve and the management team over the next year. A specific Smith and was titled ‘Quantitative for their awesome efficiency, without issue that was discussed was targeted absolute proteomics which the job would have been the disappointing fact that no (QTAP): Methods and applications infinitely harder. My best wishes nominations for new Council for studies of proteins that modulate to Tom as the incoming captain in members from the Asia Pacific xenobiotic disposition.’ steering ISSX to new horizons. IN THIS ISSUE 2 Book Review 6 22nd North American ISSX Meeting 12 Save the Date for Future Meetings 3 6th Asia Pacific ISSX Meeting 11 ISSX Welcomes New Members Book Review NATURAL PRODUCTS TARGETING Toxicological Implications,’ ‘Targeting Enzymatic CLINICALLY RELEVANT ENZYMES Pathways with Marine-Derived Clinical Agents,’ ‘Anti- Editors: P.B. Andrade, P. Valentao, D.M. Pereira. Malarial Drug Discovery: New Enzyme Inhibitors,’ John Wiley and Sons Inc. ‘Natural Plant-Derived Acetylcholinesterase 352pp., ISBN-13: 978-3-527-34205-1 Inhibitors: Relevance for Alzheimer’s Disease.’ Natural products have been exploited by mankind for As well as containing a wealth of information, each aeons as potential medicinal aids, albeit typically as chapter has its own reference section citing more crude mixtures. Recently such bioactive molecules detailed texts and original observations and a lengthy have been isolated, purified and examined for index allows easy searching and cross referencing. their usage within the field of therapeutics. Usually As usual, these books are well-made and pleasing results are confusing with many molecules having a to read. Recommended for those whose interests ‘significant effect’ but the underlying reasoning has lie within field or are slanting towards the area been evasive. This book collects together and presents of natural product medicines. The wide coverage information on enzyme systems that are known to be also provides a useful ‘entry’ into the topic. targeted by natural products and seeks to integrate and understand probable mechanisms of action. As Reviewed by explained in the promotion, ‘this volume serves as Steve Mitchell a companion for the medicinal chemist looking for Faculty of Medicine innovative small molecule compounds as well as for Imperial College London pharmacologist interested in the clinical effects and London SW7 2AZ, UK mode of action of herbal and traditional medicines.’ Book Ordering Information: Some 50 or so authors have collectively presented the John Wiley and Sons text as twelve chapters that are copiously subdivided Corporate Headquarters into many sections. The major chapter headings are; 111 River Street ‘Natural products as enzyme inhibitors,’ ‘Molecular Hoboken, NJ 07030-5774 Targets of Clinically Relevant Natural Products United States of America from Filamentous Marine Cyanobacteria,’ ‘Natural Telephone: 201.748.6000 Angiotensin Converting Enzyme (ACE) Inhibitors with Facsimile: 201.748.6088 Antihypertensive Properties,’ ‘Phospholipase A2 Email: [email protected] Inhibitors of Marine Origin,’ ‘β-Secretase (BACE1) Inhibitors from Natural Products,’ ‘Hypoglycaemic The Atrium Effects of Plants Food Constituents via Inhibition Southern Gate, Chichester of Carbohydrate-Hydrolysing Enzymes: From West Sussex PO19 8SQ Chemistry to Future Applications,’ ‘Natural Products England Targeting Clinically Relevant Enzymes of Eicosanoid Telephone: 44.1243.779777 Biosynthesis Implicated in Inflammation and Cancer,’ Facsimile: 44.1243.775878 ‘Anti-HIV Natural Products,’ ‘Natural Inhibitors of Mitochondrial Respiratory Chain: Therapeutic and Issue 4, 2017 / ISSX Newsletter / 2 6th Asia Pacific ISSX Meeting Zhejiang University • Hangzhou, China • May 11–14, 2018 Make plans to attend the 6th Asia Pacific ISSX Meeting Industry-Sponsored Sessions in exciting Hangzhou—the capital of China’s Zhejiang province. Zhejiang University is the home of the 6th Asia Parallel Sessions: Pacific ISSX Meeting. Sometimes referred to as Zheda, Zhejiang University was founded in 1897. It is one of In Vivo Function and Regulation of Drug Transporters China's oldest, most selective, and most prestigious Chairs: Yuichi Sugiyama and Wooin Lee, and Hua Li institutions of higher education. Called a splendid city by visitor Marco Polo, you will agree that Hangzhou Use of “Extended Clearance Concept” to Predict is a beautiful part of China not to be missed. Clinical Outcomes from In Vitro Metabolism and Transport Data; Focusing on the Transporters Submit an abstract today at www.issx.org/apabstract. in the Liver Abstract submission deadline is February 28, 2018. Yuichi Sugiyama, RIKEN Institute Scientific Program The Use and Abuse of Extended Clearance Concept (Preliminary and subject to change) Ayman El-Kattan, Pfizer, USA Friday, May 11, 2018 Time-dependent and Long-lasting Inhibition of OATP Transporters Short Courses/Workshops: Yoshihisa Shitara, Sanofi Integrated DMPK IND Enabling Studies Complexity and Diversity in SLCO Transporters, via Epigenetic and Splicing Regulation Mechanistic PK/PD Modeling and Simulation: Wooin Lee, Seoul National University Steps to Become a PBPK/QSP Modeler Chair: Yanyan Zhang Role of P-glycoprotein in BBB Penetration and Respiratory Toxicity of Opioid Drugs Application of PBPK Modeling in Drug Discovery Hua Li, Academy of Military Medical Sciences and Development: Case Studies Chair: Houfu Liu ADMET of Drugs and Chemicals Chairs: Bill Smith, Sylvia Zhao, and Genfu Chen Career Development Implications of Human P450 Structures Career Development Session for Drug Design James Halpert, University of Connecticut Saturday, May 12, 2018 Utility of Transgenic Mice for Identification Issue 4, 2017 of Biomarkers and Metabolism-Mediated Opening Ceremony Toxicological Mechanisms Xinxin Ding, University of Albany Keynote Lectures: From Enzymology to Human ADME: Case study • Targeted Covalent Drugs and the Promise / of a Disproportionate Metabolite of Personalized Medicine ISSX Newsletter Bill Smith, Gilead Sciences, Inc. Tom Baillie, University of Washington Unraveling the Contribution of Aldehyde Oxidase • Cellular Pharmacokinetics to Drug Clearance: Getting Closer to an Elusive Guangji Wang, China Pharmaceutical University Parameter Mike Zientek, Takeda Poster Sessions / Continued on next page 3 6th Asia Pacific ISSX Meeting Continued from previous page MicroRNAs in the Regulation of DMPK Poster Sessions Yu Am, University of California, Davis Drug Interactions and Regulatory Guidance Panel Discussion and Q&A Chairs: Dafang Zhong and Chuang Lu Poster Session Comparative Evaluation of Coproporphyrins I and III with other Endogenous Compounds as Markers of Welcome Reception OATP Inhibition in Healthy Subjects Hong Shen, Bristol-Myers Squibb Sunday, May 13, 2018 Clinical Trials Using Radiolabeled Drugs Keynote Lecture: Dafang Zhong, Chinese Academy of Sciences • Role of Transporters in Pharmacokinetics (PK)/ How PBPK Modeling Can be Leveraged for Drug-drug Pharmacodynamics (PD )/Toxicodynamics (TD) Interactions Professor Yuichi Sugiyama, RIKEN Institute Lu Chuang, Sanofi Parallel Symposia: ADMET of Herbal Medicine Chairs: Ge Lin and Chuan Li Personalized Medicine—Roles of Omics and Disease States CYP-mediated Metabolic Activation and Pyrrole- Chairs: John Miners & Min Huang Protein Adduct Formation—The Cause and Biomarker of Pyrrolizidine Alkaloid N-Oxide Induced Predictive Pharmacogenomic Biomarkers Herbal Hepatotoxicity for Personalized Medicine Tomorrow Ge Lin, Shanghai Institute of Materia Medica Magnus Ingelman-Sundberg, Karolinska Instuitute
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