Additional Table 2 All biological function categories and involved cytokines at 1, 7, 14 and 28 days after sciatic nerve injury List Pop Pop Category Term Count % P -value Genes total hits total Fold enrichment Bonferroni Benjamini False discovery rate Day 1 GOTERM_B GO:0021828~gonadotrophin- 3 0.0666370501999111 0.0000218920775503996 NRP2, NRP1, SEMA3A 31 3 10910 351.935483870967 0.004063691764008 0.004063691764008 0.0271097576750367 P_DIRECT releasing hormone neuronal migration to the hypothalamus GOTERM_B GO:1903375~facioacoustic 3 0.0666370501999111 0.0000218920775503996 NRP2, NRP1, SEMA3A 31 3 10910 351.935483870967 0.004063691764008 0.004063691764008 0.0271097576750367 P_DIRECT ganglion development GOTERM_B GO:0097490~sympathetic neuron 3 0.0666370501999111 0.0000437092389619988 NRP2, NRP1, SEMA3A 31 4 10910 263.951612903225 0.00809713627958896 0.00405679694050276 0.054120022480375 P_DIRECT projection extension GOTERM_B GO:0097491~sympathetic neuron 3 0.0666370501999111 0.0000437092389619988 NRP2, NRP1, SEMA3A 31 4 10910 263.951612903225 0.00809713627958896 0.00405679694050276 0.054120022480375 P_DIRECT projection guidance GOTERM_B GO:0048846~axon extension 3 0.0666370501999111 0.0000437092389619988 NRP2, NRP1, SEMA3A 31 4 10910 263.951612903225 0.00809713627958896 0.00405679694050276 0.054120022480375 P_DIRECT involved in axon guidance GOTERM_B GO:0036486~ventral trunk neural 3 0.0666370501999111 0.0000437092389619988 NRP2, NRP1, SEMA3A 31 4 10910 263.951612903225 0.00809713627958896 0.00405679694050276 0.054120022480375 P_DIRECT crest cell migration GOTERM_B GO:0061551~trigeminal ganglion 3 0.0666370501999111 0.0000727241031738213 NRP2, NRP1, SEMA3A 31 5 10910 211.16129032258 0.01343609399186 0.00449890781593431 0.0900308545265016 P_DIRECT development GOTERM_B GO:0060385~axonogenesis 3 0.0666370501999111 0.0000727241031738213 NRP1, NTRK1, SEMA3A 31 5 10910 211.16129032258 0.01343609399186 0.00449890781593431 0.0900308545265016 P_DIRECT involved in innervation GOTERM_B GO:0021612~facial nerve 3 0.0666370501999111 0.000202584492041162 NRP2, NRP1, SEMA3A 31 8 10910 131.975806451612 0.0369833068430469 0.00937689336329583 0.25060989132758 P_DIRECT structural organization GOTERM_B GO:0061549~sympathetic 3 0.0666370501999111 0.000260020435237439 NRP2, NRP1, SEMA3A 31 9 10910 117.311827956989 0.0472188927805887 0.00962737518360001 0.321556682575296 P_DIRECT ganglion development GOTERM_B GO:0048485~sympathetic nervous 3 0.0666370501999111 0.000395896466905332 NTRK1, GDNF, GFRA3 31 11 10910 95.9824046920821 0.071004443198981 0.0122001873036784 0.489210654974903 P_DIRECT system development GOTERM_B GO:0043524~negative regulation 4 0.0888494002665482 0.00128874933466054 HRAS, NRP1, NTRK1, GDNF 31 79 10910 17.8195181706819 0.213263553545273 0.0336855651103454 1.58444699743414 P_DIRECT of neuron apoptotic process GOTERM_B GO:0008284~positive regulation 5 0.111061750333185 0.00234317373235068 NTF3, PGF, FGFBP1, GDNF, TIMP1 31 207 10910 8.50085709833255 0.353603202616509 0.0530819403602919 2.86360326948454 P_DIRECT of cell proliferation GOTERM_B GO:0007169~transmembrane 3 0.0666370501999111 0.00283393786764009 NRTN, NTF3, GFRA2 31 29 10910 36.4071190211345 0.410134514916265 0.0569643531217523 3.45373729790252 P_DIRECT receptor protein tyrosine kinase signaling pathway GOTERM_B GO:0097374~sensory neuron axon 2 0.0444247001332741 0.00549223183632148 NRP2, NRP1 31 2 10910 351.935483870967 0.640977688872607 0.0973650532279958 6.59340796938245 P_DIRECT guidance GOTERM_B GO:0021649~vestibulocochlear 2 0.0444247001332741 0.00549223183632148 NRP2, NRP1 31 2 10910 351.935483870967 0.640977688872607 0.0973650532279958 6.59340796938245 P_DIRECT nerve structural organization GOTERM_B GO:1904835~dorsal root ganglion 2 0.0444247001332741 0.00549223183632148 NRP2, NRP1 31 2 10910 351.935483870967 0.640977688872607 0.0973650532279958 6.59340796938245 P_DIRECT morphogenesis GOTERM_B GO:0060326~cell chemotaxis 3 0.0666370501999111 0.00857237213512687 CCL2, CXCL3 31 51 10910 20.7020872865275 0.798372770321373 0.13547571283664 10.1137956790279 P_DIRECT GOTERM_B GO:0045743~positive regulation 2 0.0444247001332741 0.0109552992081338 FGFBP3, FGFBP1 31 4 10910 175.967741935483 0.871127221767186 0.156962747339677 12.7531783307393 P_DIRECT of fibroblast growth factor receptor signaling pathway GOTERM_B GO:0021785~branchiomotor 2 0.0444247001332741 0.0109552992081338 NRP1, SEMA3A 31 4 10910 175.967741935483 0.871127221767186 0.156962747339677 12.7531783307393 P_DIRECT neuron axon guidance GOTERM_B GO:1901166~neural crest cell 2 0.0444247001332741 0.0109552992081338 NRP2, NRP1 31 4 10910 175.967741935483 0.871127221767186 0.156962747339677 12.7531783307393 P_DIRECT migration involved in autonomic nervous system development GOTERM_B GO:0060666~dichotomous 2 0.0444247001332741 0.0136759429841461 NRP1, SEMA3A 31 5 10910 140.774193548387 0.922794111342528 0.178827025059579 15.6794135076415 P_DIRECT subdivision of terminal units involved in salivary gland branching GOTERM_B GO:0021637~trigeminal nerve 2 0.0444247001332741 0.0136759429841461 NRP1, SEMA3A 31 5 10910 140.774193548387 0.922794111342528 0.178827025059579 15.6794135076415 P_DIRECT structural organization GOTERM_B GO:1902287~semaphorin-plexin 2 0.0444247001332741 0.0136759429841461 NRP1, SEMA3A 31 5 10910 140.774193548387 0.922794111342528 0.178827025059579 15.6794135076415 P_DIRECT signaling pathway involved in axon guidance GOTERM_B GO:0048843~negative regulation 2 0.0444247001332741 0.0217945380347228 NRP1, SEMA3A 31 8 10910 87.983870967742 0.983404302097575 0.253797288356587 23.8837356756340 P_DIRECT of axon extension involved in axon guidance GOTERM_B GO:2000251~positive regulation 2 0.0444247001332741 0.0217945380347228 HRAS, NTF3 31 8 10910 87.983870967742 0.983404302097575 0.253797288356587 23.8837356756340 P_DIRECT of actin cytoskeleton GOTERM_B GO:0048011~neurotrophinreorganization TRK 2 0.0444247001332741 0.0244863527348708 NTRK1, SORT1 31 9 10910 78.207885304660 0.990059619638411 0.264650953687308 26.4375769787988 P_DIRECT receptor signaling pathway GOTERM_B GO:0007413~axonal fasciculation 2 0.0444247001332741 0.0298485173738343 NRP1, SEMA3A 31 11 10910 63.988269794721 0.996434202958489 0.296911833056561 31.2917224731595 P_DIRECT GOTERM_B GO:0070374~positive regulation 3 0.0666370501999111 0.0329195674493794 HRAS, NRP1, NTRK1 31 104 10910 10.151985111663 0.998022835205490 0.306664083717347 33.9374106028222 P_DIRECT of ERK1 and ERK2 cascade GOTERM_B GO:0002092~positive regulation 2 0.0444247001332741 0.0431295731387954 NTF3, CD63 31 16 10910 43.991935483871 0.999725411317371 0.365912728743961 42.0747642265996 P_DIRECT of receptor internalization GOTERM_B GO:0001755~neural crest cell 2 0.0444247001332741 0.0536277095192114 NRTN, GDNF 31 20 10910 35.193548387097 0.999964719483398 0.417011841653786 49.4722136417142 P_DIRECT migration GOTERM_B GO:0008625~extrinsic apoptotic 2 0.0444247001332741 0.0562347957200807 SORT1, NGF 31 21 10910 33.517665130568 0.999978879859737 0.416239318968733 51.1693531365012 P_DIRECT signaling pathway via death domain receptors GOTERM_B GO:0006955~immune response 3 0.0666370501999111 0.0613584612869078 CCL2, CXCL3 31 147 10910 7.182356813693 0.999992327142262 0.429275480987427 54.3530061767464 P_DIRECT GOTERM_B GO:0030593~neutrophil 2 0.0444247001332741 0.0717321271991667 LGALS3, PPBP 31 27 10910 26.069295101553 0.999999028959167 0.467042456880297 60.2225401364455 P_DIRECT chemotaxis GOTERM_B GO:0043547~positive regulation 2 0.0444247001332741 0.0844583930882933 HRAS, NTRK1 31 32 10910 21.995967741935 0.999999925505547 0.510117026933951 66.4736230748140 P_DIRECT of GTPase activity GOTERM_B GO:2001237~negative regulation 2 0.0444247001332741 0.0844583930882933 NRP1, LGALS3 31 32 10910 21.995967741935 0.999999925505547 0.510117026933951 66.4736230748140 P_DIRECT of extrinsic apoptotic signaling GOTERM_B GO:0001658~branchingpathway involved 2 0.0444247001332741 0.0869833285742652 PGF, GDNF 31 33 10910 21.329423264907 0.999999955430308 0.506019296058541 67.6009379285665 P_DIRECT in ureteric bud morphogenesis Day 7 GOTERM_B GO:0070098~chemokine- 17 0.398126463700234 5.9032086528679E-32 CXCL1, CCL1, CCL3, CCL2, CXCL2, 38 55 18082 147.078468899521 3.58324765229081E-29 3.58324765229081E-29 8.73243203864896E-29 P_DIRECT mediated signaling pathway CXCL9, CCL19, CCL5, CXCL11, CCL4, CCL7, CCL6, CXCL10, CCL17, CCL12, CCL22, PPBP GOTERM_B GO:0030593~neutrophil 15 0.351288056206089 1.93074409806996E-25 CXCL1, CCL1, CCL3, CCL2, LGALS3, 38 69 18082 103.443935926773 1.17196166752847E-22 5.85980833764235E-23 2.85608939338907E-22 P_DIRECT chemotaxis CXCL2, CCL19, CCL5, CCL4, CCL7, CCL6, CCL17, CCL12, CCL22, PPBP GOTERM_B GO:0060326~cell chemotaxis 14 0.327868852459016 2.0394561664195E-22 CXCL1, CCL1, CCL3, CCL2, CXCL2, 38 78 18082 85.407557354926 1.23794989301665E-19 4.12649964338884E-20 3.01690375799437E-19 P_DIRECT CXCL9, CCL19, CXCL11, CCL4, CCL28, CCL6, CXCL10, CCL12, CCL22

GOTERM_B GO:0006935~chemotaxis 15 0.351288056206089 6.1198755994179E-22 CCL1, CCL3, CCL2, CXCL2, CXCL9, 38 118 18082 60.488403211418 3.71476448884668E-19 9.28691122211670E-20 9.05294068014014E-19 P_DIRECT CCL5, CXCL11, CCL4, CCL28, CCL7, CCL6, CCL17, CXCL10, CCL12, CCL22

GOTERM_B GO:0006955~immune response 18 0.421545667447306 7.4829026804895E-22 CXCL1, CCL1, CCL3, CCL2, CXCL2, 38 272 18082 31.489551083591 4.54212192705713E-19 9.08424385411427E-20 1.10692240358899E-18 P_DIRECT CXCL9, CCL19, CCL5, CXCL11, CCL28, CCL4, CCL7, CCL6, CXCL10, CCL17, CCL12, CCL22, PPBP GOTERM_B GO:0048247~lymphocyte 11 0.257611241217798 3.03287793145117E-20 CCL1, CCL12, CCL22, CCL3, CCL2, 38 33 18082 158.614035087719 1.84095690439086E-17 3.06826150731810E-18 4.48644152278929E-17 P_DIRECT chemotaxis CCL19, CCL5, CCL4, CCL7, CCL6, CCL17 GOTERM_B GO:0071347~cellular response to 13 0.304449648711943 3.99659238624636E-20 CCL1, CCL12, ICAM1, CCL22, CCL3, 38 80 18082 77.324342105263 2.42593157845154E-17 3.46561654064506E-18 5.91203419213772E-17 P_DIRECT interleukin-1 CCL2, CXCL2, CCL19, CCL5, CCL4, CCL7, CCL6, CCL17 GOTERM_B GO:0002548~monocyte 11 0.257611241217798 2.74850664589721E-19 CCL1, CCL12, CCL22, CCL3, CCL2, 38 40 18082 130.856578947368 1.66834353405960E-16 2.08542941757450E-17 4.06577996890083E-16 P_DIRECT chemotaxis LGALS3, CCL19, CCL4, CCL7, CCL6, CCL17 GOTERM_B GO:0070374~positive regulation 14 0.327868852459016 3.07361727859836E-17 CCL1, FGFBP3, ICAM1, CCL3, CCL2, 38 188 18082 35.435050391937 1.86568568810920E-14 2.07298409789911E-15 4.54670596560023E-14 P_DIRECT of ERK1 and ERK2 cascade NRP1, CCL19, CCL5, CCL4, CCL7, CCL6, CCL17, CCL12, CCL22 GOTERM_B GO:0006954~inflammatory 16 0.374707259953161 7.13699825227176E-17 CXCL1, CCL1, CCL3, CCL2, CXCL2, 38 344 18082 22.1321909424724 6.7390537594747E-14 6.77236045021345E-15 1.66533453693773E-13 P_DIRECT response CXCL9, CCL19, CCL5, CXCL11, CCL4, CCL7, CCL6, CCL17, CXCL10, CCL12, CCL22 GOTERM_B GO:0043547~positive regulation 13 0.304449648711943 7.44828594315935E-17 CCL1, CCL12, F11R, ICAM1, CCL22, 38 146 18082 42.369502523432 6.73905375947470E-14 6.10622663543836E-15 1.66533453693773E-13 P_DIRECT of GTPase activity CCL3, CCL2, CCL19, CCL5, CCL4, CCL7, CCL6, CCL17 GOTERM_B GO:0071346~cellular response to 11 0.257611241217798 9.04009361981091E-17 CCL1, CCL12, CCL22, CCL3, CCL2, 38 68 18082 76.974458204334 6.73905375947470E-14 5.66213742558829E-15 1.66533453693773E-13 P_DIRECT interferon-gamma CCL19, CCL5, CCL4, CCL7, CCL6, CCL17 GOTERM_B GO:0071356~cellular response to 12 0.281030444964871 1.87246199590216E-16 CCL1, CCL12, ICAM1, CCL22, CCL3, 38 110 18082 51.910047846890 1.34781075189494E-13 1.03250741290139E-14 3.33066907387546E-13 P_DIRECT tumor necrosis factor CCL2, CCL19, CCL5, CCL4, CCL7, CCL6, CCL17 GOTERM_B GO:0050729~positive regulation 8 0.18735362997658 4.1920173345421E-11 CCL1, CCL12, CCL3, CCL2, CCL5, CCL4, 38 63 18082 60.4243943191311 2.54455210235704E-08 1.81753723182964E-09 6.20111406668399E-08 P_DIRECT of inflammatory response CCL7, CCL6 GOTERM_B GO:0048245~eosinophil 5 0.117096018735363 3.08759834406527E-09 CCL3, CCL2, LGALS3, CCL5, CCL7 38 10 18082 237.921052631578 1.87417047492477E-06 1.24944807611271E-07 4.56738770138187E-06 P_DIRECT chemotaxis GOTERM_B GO:0007186~G-protein coupled 17 0.398126463700234 6.91644034690985E-08 CXCL1, CCL1, CCL3, CCL2, CXCL2, 38 1706 18082 4.74168569136792 4.1981913066702E-05 0.0000026239212032042 0.000102312691263595 P_DIRECT receptor signaling pathway CXCL9, CCL19, CCL5, CXCL11, CCL4, CCL7, CCL6, CXCL10, CCL17, CCL12, CCL22, PPBP GOTERM_B GO:0032496~response to 8 0.187353629976580 1.27838528810044E-07 CXCL1, NOTCH1, PPBP, CXCL2, CXCL9, 38 197 18082 19.323537269570 7.75949812727994E-05 4.56457734221427E-06 1.89107372927654E-04 P_DIRECT lipopolysaccharide TIMP4, CXCL11, CXCL10 GOTERM_B GO:2000503~positive regulation 4 0.093676814988290 1.57071009931879E-07 CCL3, CCL5, CCL4, CCL7 38 6 18082 317.228070175438 9.53375656287391E-05 5.29676989113880E-06 2.32349983675383E-04 P_DIRECT of natural killer cell chemotaxis GOTERM_B GO:0048246~macrophage 4 0.093676814988290 2.82660462941095E-06 CCL12, CCL3, CCL2, LGALS3 38 14 18082 135.954887218045 1.71428037484844E-03 9.02986299331498E-05 4.18122636841600E-03 P_DIRECT chemotaxis GOTERM_B GO:0002690~positive regulation 4 0.093676814988290 3.52827496335520E-06 PPBP, CXCL9, CXCL11, CXCL10 38 15 18082 126.891228070175 2.13937494917038E-03 1.07077600830618E-04 5.21913987264754E-03 P_DIRECT of leukocyte chemotaxis GOTERM_B GO:0031663~lipopolysaccharide- 4 0.093676814988290 3.40786556831244E-05 CCL12, CCL3, CCL2, CCL5 38 31 18082 61.398981324278 2.04736069006745E-02 9.84567208612508E-04 5.03996442347554E-02 P_DIRECT mediated signaling pathway GOTERM_B GO:0010332~response to gamma 4 0.093676814988290 4.51760296295588E-05 CCL2, CXCL2, CCL7, CXCL10 38 34 18082 55.981424148607 2.70498869733761E-02 1.24569935383889E-03 6.68066724705318E-02 P_DIRECT radiation GOTERM_B GO:0010818~T cell chemotaxis 3 0.070257611241218 6.07972024858300E-05 CCL3, CXCL11, CXCL10 38 6 18082 237.921052631578 3.62323339890956E-02 1.60327962318929E-03 8.98977030508119E-02 P_DIRECT GOTERM_B GO:0043491~protein kinase B 4 0.093676814988290 6.33293613376262E-05 CCL12, CCL3, CCL2, CCL5 38 38 18082 50.088642659280 3.77126185408529E-02 1.60047369057869E-03 9.36402413338588E-02 P_DIRECT signaling GOTERM_B GO:0042127~regulation of cell 6 0.140515222482435 9.37282205465236E-05 NOTCH1, PPBP, CXCL2, CXCL9, 38 227 18082 12.577324368189 5.53074008193397E-02 2.27324011842977E-03 1.38559642354474E-01 P_DIRECT proliferation CXCL11, CXCL10 GOTERM_B GO:0008284~positive regulation 8 0.187353629976580 9.85409427211579E-05 NOTCH2, NOTCH1, LGALS3, GAS1, 38 542 18082 7.023499708681 5.80633898520958E-02 2.29802086350527E-03 1.45669517757152E-01 P_DIRECT of cell proliferation FGFBP1, TIMP1, CXCL10, NGF GOTERM_B GO:0043615~astrocyte cell 3 0.070257611241218 1.13195532019916E-04 CCL12, CCL3, CCL2 38 8 18082 178.440789473684 6.64059554477463E-02 2.54171166498773E-03 1.67315960607761E-01 P_DIRECT migration GOTERM_B GO:0030816~positive regulation 3 0.070257611241218 1.45349423664983E-04 CXCL9, CXCL11, CXCL10 38 9 18082 158.614035087719 8.44529400741403E-02 3.14623707115158E-03 2.14795470147710E-01 P_DIRECT of cAMP metabolic process GOTERM_B GO:0008360~regulation of cell 5 0.117096018735363 1.81368801332838E-04 CCL12, ICAM1, CCL3, CCL2, CCL7 38 139 18082 17.116622491481 1.04256202458862E-01 3.78938303448661E-03 2.67957881816116E-01 P_DIRECT shape GOTERM_B GO:0032760~positive regulation 4 0.093676814988290 2.36934778820263E-04 CCL3, CCL2, CCL19, CCL4 38 59 18082 32.260481712756 1.33970625583790E-01 4.78307287838819E-03 3.49918095171375E-01 P_DIRECT of tumor necrosis factor GOTERM_B GO:0043950~positiveproduction regulation 3 0.070257611241218 2.65444562590037E-04 CXCL9, CXCL11, CXCL10 38 12 18082 118.960526315789 1.48832411155275E-01 5.18477814373496E-03 3.91945847980390E-01 P_DIRECT of cAMP-mediated signaling GOTERM_B GO:0043922~negative regulation 3 0.070257611241218 2.65444562590037E-04 CCL3, CCL5, CCL4 38 12 18082 118.960526315789 1.48832411155275E-01 5.18477814373496E-03 3.91945847980390E-01 P_DIRECT by host of viral transcription GOTERM_B GO:0043524~negative regulation 5 0.117096018735363 3.10590143560994E-04 CCL12, CCL2, NRP1, GFRAL, NGF 38 160 18082 14.870065789474 1.71847117307644E-01 5.87509562715671E-03 4.58463488449312E-01 P_DIRECT of neuron apoptotic process GOTERM_B GO:0090026~positive regulation 3 0.070257611241218 3.65048878762491E-04 CCL2, CCL5, CXCL10 38 14 18082 101.966165413533 1.98784335330474E-01 6.69341150246627E-03 5.38648044698097E-01 P_DIRECT of monocyte chemotaxis GOTERM_B GO:0000165~MAPK cascade 4 0.093676814988290 3.76526772441838E-04 CCL12, CCL3, CCL2, CCL5 38 69 18082 27.585049580473 2.04349125800258E-01 6.70082483990541E-03 5.55540306933766E-01 P_DIRECT GOTERM_B GO:0071407~cellular response to 4 0.093676814988290 4.81187035823124E-04 CCL12, CCL3, LGALS1, CCL5 38 75 18082 25.378245614035 2.53344087627958E-01 8.31242559238187E-03 7.09447705365140E-01 P_DIRECT organic cyclic compound GOTERM_B GO:0090280~positive regulation 3 0.070257611241218 8.34853186681802E-04 CCL12, CCL2, LGALS3 38 21 18082 67.977443609023 3.97680675841596E-01 1.39837379279258E-02 1.22788720205395E+00 P_DIRECT of calcium ion import GOTERM_B GO:0030595~leukocyte 3 0.070257611241218 9.17156051995144E-04 CCL3, CXCL2, CCL4 38 22 18082 64.887559808612 4.27057076081981E-01 1.49404876296205E-02 1.34817246246123E+00 P_DIRECT chemotaxis GOTERM_B GO:0035924~cellular response to 3 0.0702576112412178 0.000917156051995144 NOTCH1, NRP1, GAS1 38 22 18082 64.8875598086124 0.427057076081981 0.0149404876296205 1.34817246246123 P_DIRECT vascular endothelial growth factor stimulus GOTERM_B GO:0007169~transmembrane 4 0.0936768149882903 0.00111250334001252 GFRA1, GFRA4, GFRA2, GFRA3 38 100 18082 19.0336842105263 0.491182278281599 0.0176235260460573 1.63312503560142 P_DIRECT receptor protein tyrosine kinase signaling pathway GOTERM_B GO:0045672~positive regulation 3 0.0702576112412178 0.00118651776556075 NOTCH2, CCL3, CCL5 38 25 18082 57.1010526315789 0.513561061320582 0.0183083761715264 1.74088906972269 P_DIRECT of osteoclast differentiation GOTERM_B GO:0007010~cytoskeleton 4 0.0936768149882903 0.00124586627789839 CCL12, CCL3, CCL2, CCL7 38 104 18082 18.3016194331983 0.530793500407298 0.0187399890985349 1.82722019425165 P_DIRECT organization GOTERM_B GO:0045662~negative regulation 3 0.0702576112412178 0.00128373997771558 NOTCH1, CCL17, CXCL10 38 26 18082 54.9048582995951 0.541470550567919 0.0188381255535509 1.88227607826352 P_DIRECT of myoblast differentiation GOTERM_B GO:0001525~angiogenesis 5 0.117096018735363 0.00139567271277801 NRP2, CCL12, NOTCH1, CCL2, NRP1 38 239 18082 9.95485575864347 0.571628759775248 0.0199825317718248 2.04482118390011 P_DIRECT GOTERM_B GO:0090023~positive regulation 3 0.0702576112412178 0.00148924838869736 CXCL1, CXCL2, CCL19 38 28 18082 50.9830827067669 0.595315513724949 0.0208185538672501 2.18051603782418 P_DIRECT of neutrophil chemotaxis GOTERM_B GO:0051928~positive regulation 3 0.0702576112412178 0.00170941103594976 CCL3, CCL5, CCL4 38 30 18082 47.5842105263157 0.646014867002205 0.0233259256390591 2.49908472033634 P_DIRECT of calcium ion transport GOTERM_B GO:0043086~negative regulation 3 0.0702576112412178 0.00182495120008652 NOTCH1, TIMP4, TIMP1 38 31 18082 46.0492359932088 0.670031274600523 0.0243379895808834 2.66588054256335 P_DIRECT of catalytic activity GOTERM_B GO:0051281~positive regulation 3 0.0702576112412178 0.00206687657707831 CXCL9, CXCL11, CXCL10 38 33 18082 43.2583732057416 0.715178444868289 0.0269326780121939 3.01426690265417 P_DIRECT of release of sequestered calcium ion into cytosol GOTERM_B GO:0007204~positive regulation 4 0.0936768149882903 0.00340514389390754 CXCL1, CCL3, CXCL2, CCL28 38 148 18082 12.8605974395448 0.873870918075927 0.0430959135286768 4.92053639966733 P_DIRECT of cytosolic calcium ion concentration GOTERM_B GO:0007411~axon guidance 4 0.0936768149882903 0.00347024893539565 NRP2, NRP1, GAS1, GFRA3 38 149 18082 12.7742847050512 0.878774704581280 0.0430082524475136 5.01237687733768 P_DIRECT GOTERM_B GO:1904835~dorsal root ganglion 2 0.0468384074941451 0.00408839351330704 NRP2, NRP1 38 2 18082 475.8421052631570 0.916819449195989 0.0494835695388126 5.88025156091254 P_DIRECT morphogenesis GOTERM_B GO:0021649~vestibulocochlear 2 0.0468384074941451 0.00408839351330704 NRP2, NRP1 38 2 18082 475.8421052631570 0.916819449195989 0.0494835695388126 5.88025156091254 P_DIRECT nerve structural organization GOTERM_B GO:0097374~sensory neuron axon 2 0.0468384074941451 0.00612648695585610 NRP2, NRP1 38 3 18082 317.2280701754380 0.976012342335364 0.0718893486149572 8.68964238077655 P_DIRECT guidance GOTERM_B GO:2000502~negative regulation 2 0.0468384074941451 0.00612648695585610 CCL12, CCL2 38 3 18082 317.2280701754380 0.976012342335364 0.0718893486149572 8.68964238077655 P_DIRECT of natural killer cell chemotaxis GOTERM_B GO:0050793~regulation of 2 0.0468384074941451 0.00612648695585610 NOTCH2, NOTCH1 38 3 18082 317.2280701754380 0.976012342335364 0.0718893486149572 8.68964238077655 P_DIRECT developmental process GOTERM_B GO:1903375~facioacoustic 2 0.0468384074941451 0.00612648695585610 NRP2, NRP1 38 3 18082 317.2280701754380 0.976012342335364 0.0718893486149572 8.68964238077655 P_DIRECT ganglion development GOTERM_B GO:0021828~gonadotrophin- 2 0.0468384074941451 0.0061264869558561 NRP2, NRP1 38 3 18082 317.228070175438 0.976012342335364 0.0718893486149572 8.68964238077655 P_DIRECT releasing hormone neuronal migration to the hypothalamus GOTERM_B GO:0038084~vascular endothelial 2 0.0468384074941451 0.00816052202305082 NRP2, NRP1 38 4 18082 237.921052631578 0.993082901002799 0.0929200478958667 11.4153240180904 P_DIRECT growth factor signaling pathway GOTERM_B GO:1902285~semaphorin-plexin 2 0.0468384074941451 0.00816052202305082 NRP2, NRP1 38 4 18082 237.9210526315780 0.993082901002799 0.0929200478958667 11.41532401809040 P_DIRECT signaling pathway involved in neuron projection guidance GOTERM_B GO:0097490~sympathetic neuron 2 0.0468384074941451 0.00816052202305082 NRP2, NRP1 38 4 18082 237.921052631578 0.993082901002799 0.0929200478958667 11.4153240180904 P_DIRECT projection extension GOTERM_B GO:0036486~ventral trunk neural 2 0.0468384074941451 0.00816052202305082 NRP2, NRP1 38 4 18082 237.921052631578 0.993082901002799 0.0929200478958667 11.4153240180904 P_DIRECT crest cell migration GOTERM_B GO:0045185~maintenance of 2 0.0468384074941451 0.00816052202305082 LGALS3, LGALS1 38 4 18082 237.921052631578 0.993082901002799 0.0929200478958667 11.4153240180904 P_DIRECT protein location GOTERM_B GO:0097491~sympathetic neuron 2 0.0468384074941451 0.00816052202305082 NRP2, NRP1 38 4 18082 237.921052631578 0.993082901002799 0.0929200478958667 11.4153240180904 P_DIRECT projection guidance GOTERM_B GO:0030335~positive regulation 4 0.0936768149882903 0.00818174044739683 NOTCH1, CCL3, CCL5, CXCL10 38 203 18082 9.376199118486 0.993172143622905 0.0914441634306604 11.4433533889448 P_DIRECT of cell migration GOTERM_B GO:0071222~cellular response to 4 0.0936768149882903 0.00885819019876906 ICAM1, CCL2, CXCL2, CXCL10 38 209 18082 9.107025938051 0.995487382541330 0.0968831727148156 12.3326161647605 P_DIRECT lipopolysaccharide GOTERM_B GO:0061551~trigeminal ganglion 2 0.0468384074941451 0.01019050657233560 NRP2, NRP1 38 5 18082 190.336842105263 0.998005517474240 0.1087555134563820 14.0597862597454 P_DIRECT development GOTERM_B GO:0050679~positive regulation 3 0.0702576112412178 0.01055752648488030 NOTCH1, GAS1, CCL5 38 76 18082 18.783240997230 0.998407558807720 0.1105358970039320 14.5299739995738 P_DIRECT of epithelial cell proliferation GOTERM_B GO:0034097~response to cytokine 3 0.0702576112412178 0.01192571070757470 TIMP4, CCL5, TIMP1 38 81 18082 17.623781676413 0.999312478343792 0.1219424710779180 16.2616958249002 P_DIRECT GOTERM_B GO:0021637~trigeminal nerve 2 0.0468384074941451 0.01221644844671060 NRP2, NRP1 38 6 18082 158.614035087719 0.999424948723450 0.1226906722999610 16.6254449703259 P_DIRECT structural organization GOTERM_B GO:0002693~positive regulation 2 0.0468384074941451 0.01221644844671060 ICAM1, CCL2 38 6 18082 158.614035087719 0.999424948723450 0.1226906722999610 16.6254449703259 P_DIRECT of cellular extravasation GOTERM_B GO:0072602~interleukin-4 2 0.0468384074941451 0.01221644844671060 NOTCH2, NOTCH1 38 6 18082 158.614035087719 0.999424948723450 0.1226906722999610 16.6254449703259 P_DIRECT secretion GOTERM_B GO:0009636~response to toxic 3 0.0702576112412178 0.01336750461390410 CCL3, CCL5, CCL4 38 86 18082 16.599143206854 0.999716641016093 0.1313728566449340 18.0511463128895 P_DIRECT substance GOTERM_B GO:1901166~neural crest cell 2 0.0468384074941451 0.0142383554731058 NRP2, NRP1 38 7 18082 135.954887218045 0.999834212036508 0.137171211406424 19.1146442809274 P_DIRECT migration involved in autonomic nervous system development GOTERM_B GO:0051045~negative regulation 2 0.0468384074941451 0.0142383554731058 TIMP4, TIMP1 38 7 18082 135.954887218045 0.999834212036508 0.137171211406424 19.1146442809274 P_DIRECT of membrane protein ectodomain proteolysis GOTERM_B GO:0045743~positive regulation 2 0.0468384074941451 0.0142383554731058 FGFBP3, FGFBP1 38 7 18082 135.954887218045 0.999834212036508 0.137171211406424 19.1146442809274 P_DIRECT of fibroblast growth factor receptor signaling pathway GOTERM_B GO:0042060~wound healing 3 0.0702576112412178 0.0158236025418498 NOTCH2, CXCL2, TIMP1 38 94 18082 15.1864501679731 0.999937586583515 0.149016186907326 21.0176140665403 P_DIRECT GOTERM_B GO:0034351~negative regulation 2 0.0468384074941451 0.0162562354645382 CCL12, CCL2 38 8 18082 118.960526315789 0.999952206426125 0.150487072951341 21.5296587179624 P_DIRECT of glial cell apoptotic process GOTERM_B GO:0006874~cellular calcium ion 3 0.0702576112412178 0.0177829552546596 CCL3, CCL2, CCL5 38 100 18082 14.2752631578947 0.999981382041562 0.161103115420086 23.311987037802 P_DIRECT homeostasis GOTERM_B GO:0061549~sympathetic 2 0.0468384074941451 0.0182700962199511 NRP2, NRP1 38 9 18082 105.742690058479 0.999986222954289 0.162771993665606 23.8726952659661 P_DIRECT ganglion development GOTERM_B GO:0060982~coronary artery 2 0.0468384074941451 0.0182700962199511 NOTCH1, NRP1 38 9 18082 105.742690058479 0.999986222954289 0.162771993665606 23.8726952659661 P_DIRECT morphogenesis GOTERM_B GO:0007267~cell-cell signaling 3 0.0702576112412178 0.0187994085851358 CCL3, CCL5, FGFBP1 38 103 18082 13.8594787940725 0.99999006917357 0.164728050935826 24.4776090048414 P_DIRECT GOTERM_B GO:0021612~facial nerve 2 0.0468384074941451 0.0202799455210211 NRP2, NRP1 38 10 18082 95.1684210526315 0.999996028882195 0.17414015503633 26.1458953660241 P_DIRECT structural organization GOTERM_B GO:0048846~axon extension 2 0.0468384074941451 0.0202799455210211 NRP2, NRP1 38 10 18082 95.1684210526315 0.999996028882195 0.17414015503633 26.1458953660241 P_DIRECT involved in axon guidance GOTERM_B GO:0090557~establishment of 2 0.0468384074941451 0.0202799455210211 F11R, ICAM1 38 10 18082 95.1684210526315 0.999996028882195 0.17414015503633 26.1458953660241 P_DIRECT endothelial intestinal barrier GOTERM_B GO:0003184~pulmonary valve 2 0.0468384074941451 0.0222857911403825 NOTCH2, NOTCH1 38 11 18082 86.5167464114832 0.999998855437489 0.187208063158953 28.3513368679443 P_DIRECT morphogenesis GOTERM_B GO:0021785~branchiomotor 2 0.0468384074941451 0.0222857911403825 NRP2, NRP1 38 11 18082 86.5167464114832 0.999998855437489 0.187208063158953 28.3513368679443 P_DIRECT neuron axon guidance GOTERM_B GO:0010466~negative regulation 3 0.0702576112412178 0.0238563157474487 TIMP4, TIMP1, NGF 38 117 18082 12.2010796221322 0.999999568634449 0.196478145416384 30.0351089398744 P_DIRECT of peptidase activity GOTERM_B GO:0002237~response to 2 0.0468384074941451 0.0262855023292919 CXCL1, CXCL2 38 13 18082 73.2064777327935 0.999999904938815 0.211620466263868 32.5669487202231 P_DIRECT molecule of bacterial origin GOTERM_B GO:1902287~semaphorin-plexin 2 0.0468384074941451 0.0262855023292919 NRP2, NRP1 38 13 18082 73.2064777327935 0.999999904938815 0.211620466263868 32.5669487202231 P_DIRECT signaling pathway involved in axon guidance GOTERM_B GO:0043117~positive regulation 2 0.0468384074941451 0.0262855023292919 FGFBP3, CCL4 38 13 18082 73.2064777327935 0.999999904938815 0.211620466263868 32.5669487202231 P_DIRECT of vascular permeability GOTERM_B GO:0021675~nerve development 2 0.0468384074941451 0.0262855023292919 NRP2, NRP1 38 13 18082 73.2064777327935 0.999999904938815 0.211620466263868 32.5669487202231 P_DIRECT GOTERM_B GO:0002523~leukocyte migration 2 0.0468384074941451 0.0262855023292919 CCL2, PPBP 38 13 18082 73.2064777327935 0.999999904938815 0.211620466263868 32.5669487202231 P_DIRECT involved in inflammatory response GOTERM_B GO:0001764~neuron migration 3 0.0702576112412178 0.0265716155852028 NRP2, NRP1, GFRA3 38 124 18082 11.5123089983022 0.999999920469903 0.210941591292847 32.8594625418821 P_DIRECT GOTERM_B GO:0007219~Notch signaling 3 0.0702576112412178 0.0269693530072667 NOTCH2, NOTCH1, TIMP4 38 125 18082 11.4202105263157 0.999999937942087 0.211067296022740 33.2641325261979 P_DIRECT pathway GOTERM_B GO:0070986~left/right axis 2 0.0468384074941451 0.0282793833634344 NOTCH2, NOTCH1 38 14 18082 67.9774436090225 0.999999972606963 0.217493615256618 34.5809734648470 P_DIRECT specification GOTERM_B GO:0007220~Notch receptor 2 0.0468384074941451 0.0282793833634344 NOTCH2, NOTCH1 38 14 18082 67.9774436090225 0.999999972606963 0.217493615256618 34.5809734648470 P_DIRECT processing GOTERM_B GO:0001775~cell activation 2 0.0468384074941451 0.0282793833634344 CCL3, TIMP1 38 14 18082 67.9774436090225 0.999999972606963 0.217493615256618 34.5809734648470 P_DIRECT GOTERM_B GO:0010812~negative regulation 2 0.0468384074941451 0.0302692916422470 NOTCH1, LGALS1 38 15 18082 63.4456140350877 0.999999992106907 0.228276426707181 36.5349518950304 P_DIRECT of cell-substrate adhesion GOTERM_B GO:0050918~positive chemotaxis 2 0.0468384074941451 0.0302692916422470 NRP1, LGALS3 38 15 18082 63.4456140350877 0.999999992106907 0.228276426707181 36.5349518950304 P_DIRECT GOTERM_B GO:0042493~response to drug 4 0.0936768149882903 0.0317278325378978 ICAM1, CCL3, LGALS1, TIMP4 38 339 18082 5.61465610929979 0.999999996834435 0.235164874982201 37.9324458742592 P_DIRECT GOTERM_B GO:2000406~positive regulation 2 0.0468384074941451 0.0322552348684785 CCL5, CXCL10 38 16 18082 59.4802631578947 0.999999997725823 0.235811799085565 38.4306710641602 P_DIRECT of T cell migration GOTERM_B GO:0010759~positive regulation 2 0.0468384074941451 0.0322552348684785 CCL2, CCL5 38 16 18082 59.4802631578947 0.999999997725823 0.235811799085565 38.4306710641602 P_DIRECT of macrophage chemotaxis GOTERM_B GO:0048485~sympathetic nervous 2 0.0468384074941451 0.0342372207134216 NRP1, GFRA3 38 17 18082 55.9814241486068 0.999999999344803 0.245686954722634 40.2698649194515 P_DIRECT system development GOTERM_B GO:0002437~inflammatory 2 0.0468384074941451 0.0342372207134216 NOTCH2, NOTCH1 38 17 18082 55.9814241486068 0.999999999344803 0.245686954722634 40.2698649194515 P_DIRECT response to antigenic stimulus GOTERM_B GO:0007399~nervous system 4 0.0936768149882903 0.041442274709485 NRP2, NRP1, GFRA1, GFRA2 38 377 18082 5.04872260226162 0.999999999993045 0.286838256590767 46.5331204829618 P_DIRECT development GOTERM_B GO:0030279~negative regulation 2 0.0468384074941451 0.0421257434689557 NOTCH1, GFRA4 38 21 18082 45.3182957393483 0.999999999995489 0.287716748651633 47.0942951260991 P_DIRECT of ossification GOTERM_B GO:0050718~positive regulation 2 0.0468384074941451 0.0440880571548733 CCL3, CCL19 38 22 18082 43.2583732057416 0.9999999999987 0.295937851039112 48.6751212829871 P_DIRECT of interleukin-1 beta secretion GOTERM_B GO:0002687~positive regulation 2 0.0468384074941451 0.0440880571548733 CCL12, CCL2 38 22 18082 43.2583732057416 0.9999999999987 0.295937851039112 48.6751212829871 P_DIRECT of leukocyte migration GOTERM_B GO:0046579~positive regulation 2 0.0468384074941451 0.0440880571548733 NOTCH2, NGF 38 22 18082 43.2583732057416 0.9999999999987 0.295937851039112 48.6751212829871 P_DIRECT of Ras protein signal transduction GOTERM_B GO:0007159~leukocyte cell-cell 2 0.0468384074941451 0.0480009573410387 ICAM1, CCL5 38 24 18082 39.6535087719298 0.9999999999999 0.314744246212967 51.6967230654034 P_DIRECT adhesion GOTERM_B GO:0050850~positive regulation 2 0.0468384074941451 0.0480009573410387 CCL3, CCL4 38 24 18082 39.6535087719298 0.9999999999999 0.314744246212967 51.6967230654034 P_DIRECT of calcium-mediated signaling GOTERM_B GO:0048010~vascular endothelial 2 0.0468384074941451 0.0499515589916433 CCL2, NRP1 38 25 18082 38.0673684210526 0.999999999999969 0.32213084090037 53.1402647570597 P_DIRECT growth factor receptor signaling pathway GOTERM_B GO:0031295~T cell costimulation 2 0.0468384074941451 0.0499515589916433 LGALS1, CCL19 38 25 18082 38.0673684210526 1.0000000000000 0.322130840900370 53.1402647570597 P_DIRECT GOTERM_B GO:0002040~sprouting 2 0.0468384074941451 0.0577151520136465 NOTCH1, NRP1 38 29 18082 32.8166969147005 1.0000000000000 0.359489982086567 58.4964287121455 P_DIRECT angiogenesis GOTERM_B GO:0044344~cellular response to 2 0.0468384074941451 0.0596463844621999 CCL2, CCL5 38 30 18082 31.7228070175438 1.0000000000000 0.365707279832394 59.7371001313157 P_DIRECT fibroblast growth factor stimulus GOTERM_B GO:2001240~negative regulation 2 0.0468384074941451 0.0654170036272407 GFRAL, GAS1 38 33 18082 28.8389154704944 1.000000000000000 0.39029313084739 63.2413618270014 P_DIRECT of extrinsic apoptotic signaling pathway in absence of ligand GOTERM_B GO:0001975~response to 2 0.0468384074941451 0.0673328754682339 ICAM1, CXCL2 38 34 18082 27.9907120743034 1.0000000000000 0.395718718921421 64.3404324599988 P_DIRECT amphetamine GOTERM_B GO:0030513~positive regulation 2 0.0468384074941451 0.0711531619069038 NOTCH2, NOTCH1 38 36 18082 26.4356725146198 1.0000000000000 0.409685825561361 66.4411402975018 P_DIRECT of BMP signaling pathway GOTERM_B GO:0043200~response to amino 2 0.0468384074941451 0.0711531619069038 ICAM1, CCL2 38 36 18082 26.4356725146198 1.0000000000000 0.409685825561361 66.4411402975018 P_DIRECT acid GOTERM_B GO:0030154~cell differentiation 5 0.1170960187353630 0.0737784092044261 NRP2, NOTCH2, NOTCH1, NRP1, 38 780 18082 3.0502699055331 1.0000000000000 0.417804126480232 67.8171925750473 P_DIRECT LGALS3 GOTERM_B GO:2001237~negative regulation 2 0.0468384074941451 0.0862826267689396 NRP1, LGALS3 38 44 18082 21.6291866028708 1.000000000000000 0.46717566169021 73.6789973874092 P_DIRECT of extrinsic apoptotic signaling pathway GOTERM_B GO:0007507~heart development 3 0.0702576112412178 0.0994772349487885 NRP2, NOTCH1, NRP1 38 261 18082 5.4694494857834 1.0000000000000 0.514580940153922 78.7746791190570 P_DIRECT Day 14 GOTERM_B GO:0070374~positive regulation 16 0.340353116358221 1.68424047139835E-20 FGFBP3, CCL1, ICAM1, CCL3, HRAS, 39 186 17535 38.6765922249793 1.15033624196507E-17 1.15033624196507E-17 2.53157889237664E-17 P_DIRECT of ERK1 and ERK2 cascade NRP1, CCL2, CX3CL1, CCL5, CCL4, CCL7, CCL17, VEGFB, CCL12, NTRK1, VEGFA GOTERM_B GO:0070098~chemokine- 12 0.2552648372686660 0.0000000000000000 CXCL1, CCL1, CCL12, CCL3, CCL2, 39 57 17535 94.6558704453441 0.000000000000000 0.00000000000000 0.0000000000000 P_DIRECT mediated signaling pathway CXCL2, CX3CL1, CCL5, CCL4, CCL7, CCL17, CXCL10 GOTERM_B GO:0030593~neutrophil 12 0.2552648372686660 0.0000000000000000 CXCL1, CCL1, CCL12, CCL3, CCL2, 39 58 17535 93.0238726790451 0.000000000000000 0.00000000000000 0.0000000000000 P_DIRECT chemotaxis LGALS3, CXCL2, CX3CL1, CCL5, CCL4, CCL7, CCL17 GOTERM_B GO:0002548~monocyte 10 0.2127206977238880 0.0000000000000000 CCL1, CCL12, CCL3, CCL2, LGALS3, 39 32 17535 140.5048076923070 0.0000000000000 0.000000000000002 0.0000000000000 P_DIRECT chemotaxis CX3CL1, CCL5, CCL4, CCL7, CCL17 GOTERM_B GO:0006954~inflammatory 16 0.340353116358221 2.02581205199712E-17 CCL1, CXCL1, CCL3, CCL2, CXCL2, 39 297 17535 24.2217042217042 1.38362963151403E-14 2.76725926302807E-15 3.04499453483632E-14 P_DIRECT response IL13, CX3CL1, CCL5, AGER, CCL4, CCL7, CXCL10, CCL17, CCL12, NGFR, NGF GOTERM_B GO:0048247~lymphocyte 9 0.191448627951499 6.89804045885260E-17 CCL1, CCL12, CCL3, CCL2, CX3CL1, 39 22 17535 183.933566433566 7.58282325818981E-14 1.26565424807267E-14 1.66533453693773E-13 P_DIRECT chemotaxis CCL5, CCL4, CCL7, CCL17 GOTERM_B GO:0071346~cellular response to 10 0.212720697723888 6.01673617210552E-15 CCL1, ICAM1, CCL12, CCL3, CCL2, 39 61 17535 73.7074401008827 4.0947245594225E-12 5.84976511674995E-13 9.01501095995627E-12 P_DIRECT interferon-gamma CX3CL1, CCL5, CCL4, CCL7, CCL17 GOTERM_B GO:0071347~cellular response to 11 0.2339927674962770 0.0000000000000077 CCL1, ICAM1, CCL12, CCL3, CCL2, 39 98 17535 50.4670329670329 0.000000000005308 0.00000000000066 0.0000000000117 P_DIRECT interleukin-1 CXCL2, CX3CL1, CCL5, CCL4, CCL7, CCL17 GOTERM_B GO:0071356~cellular response to 10 0.212720697723888 8.55153317703553E-12 CCL1, ICAM1, CCL12, CCL3, CCL2, 39 133 17535 33.8056680161943 5.8406696146207E-09 6.48963327520846E-10 1.28537291921304E-08 P_DIRECT tumor necrosis factor CX3CL1, CCL5, CCL4, CCL7, CCL17 GOTERM_B GO:0050729~positive regulation 8 0.170176558179110 6.33757968238136E-11 CCL1, CCL12, CCL3, CCL2, CX3CL1, 39 63 17535 57.0940170940170 4.3285635742407E-08 4.32856361864963E-09 9.52599776837814E-08 P_DIRECT of inflammatory response CCL4, AGER, CCL7 GOTERM_B GO:0043547~positive regulation 12 0.2552648372686660 0.0000000004982340 CCL1, ICAM1, CCL12, HRAS, CCL3, 39 398 17535 13.5562427522226 0.000000340293771 0.00000003093580 0.0000007488947 P_DIRECT of GTPase activity CCL2, NTRK1, CX3CL1, CCL5, CCL4, CCL7, CCL17 GOTERM_B GO:0043524~negative regulation 9 0.191448627951499 1.41385892161108E-09 VEGFB, HRAS, CCL2, NRP1, GFRAL, 39 158 17535 25.6110029211295 9.65665175933772E-07 8.04721336233882E-08 2.12516882980295E-06 P_DIRECT of neuron apoptotic process NTRK1, NGFR, GDNF, NGF GOTERM_B GO:0048245~eosinophil 5 0.106360348861944 3.89991180327406E-09 CCL12, CCL3, LGALS3, CCL5, CCL7 39 10 17535 224.807692307692 2.66363624301657E-06 2.04895347466482E-07 5.86195046947679E-06 P_DIRECT chemotaxis GOTERM_B GO:0008284~positive regulation 12 0.2552648372686660 0.0000000057947035 HRAS, LGALS3, S100B, PGF, VEGFA, 39 503 17535 10.7264107661721 0.000003957774666 0.00000028269871 0.0000087100083 P_DIRECT of cell proliferation KITLG, GAS1, GDNF, FGFBP1, TIMP1, NGF, CXCL10 GOTERM_B GO:0048010~vascular endothelial 5 0.1063603488619440 0.0000001092655472 VEGFB, CCL2, NRP1, PGF, VEGFA 39 21 17535 107.0512820512820 0.000074625588164 0.00000497521248 0.0001642367260 P_DIRECT growth factor receptor signaling pathway GOTERM_B GO:0045766~positive regulation 7 0.148904488406721 1.79860497524925E-07 VEGFB, LGALS3, PGF, NTRK1, VEGFA, 39 117 17535 26.9000657462195 1.22837185732027E-04 7.67776620314020E-06 2.70347656539105E-04 P_DIRECT of angiogenesis CX3CL1, CCL5 GOTERM_B GO:2000503~positive regulation 4 0.085088279089555 1.86948807037206E-07 CCL3, CCL5, CCL4, CCL7 39 6 17535 299.7435897435890 1.27677895593536E-04 7.51091574058282E-06 2.81002054669521E-04 P_DIRECT of natural killer cell chemotaxis GOTERM_B GO:0030335~positive regulation 8 0.170176558179110 2.50062114754542E-07 HRAS, CCL3, VEGFA, CX3CL1, CCL5, 39 205 17535 17.5459662288930 1.70777861558280E-04 9.48842419334905E-06 3.75867265856033E-04 P_DIRECT of cell migration AGER, CCL7, CXCL10 GOTERM_B GO:0008360~regulation of cell 7 0.148904488406721 2.79262649879214E-07 ICAM1, CCL12, CCL3, CCL2, S100B, 39 126 17535 24.9786324786324 1.90718227476405E-04 1.00387083755704E-05 4.19758375858059E-04 P_DIRECT shape VEGFA, CCL7 GOTERM_B GO:0060754~positive regulation 4 0.085088279089555 3.26670647426107E-07 VEGFB, PGF, VEGFA, CCL5 39 7 17535 256.9230769230760 2.23091200088121E-04 1.11557422057817E-05 4.91016950698863E-04 P_DIRECT of mast cell chemotaxis GOTERM_B GO:0050918~positive chemotaxis 5 0.106360348861944 3.69763659725979E-07 CCL3, NRP1, LGALS3, VEGFA, CCL5 39 28 17535 80.2884615384615 2.52516738540875E-04 1.20260527465276E-05 5.55789665235284E-04 P_DIRECT GOTERM_B GO:0051384~response to 7 0.148904488406721 3.84529704557848E-07 CXCL1, CCL1, CCL2, S100B, CXCL2, 39 133 17535 23.6639676113360 2.62599353436532E-04 1.19378305019068E-05 5.77984363814287E-04 P_DIRECT glucocorticoid CCL5, NGF GOTERM_B GO:0006955~immune response 8 0.170176558179110 1.47889281572751E-06 CXCL1, CXCL2, IL13, CX3CL1, NGFR, 39 267 17535 13.4716220109478 1.00957457639860E-03 4.39157548085544E-05 2.22289812908949E-03 P_DIRECT CCL4, CCL17, CXCL10 GOTERM_B GO:0032496~response to 8 0.170176558179110 2.02896088747185E-06 CXCL1, ICAM1, CCL2, IL13, NGFR, 39 280 17535 12.8461538461538 1.38482193996525E-03 5.77392368605877E-05 3.04968413405992E-03 P_DIRECT lipopolysaccharide CCL5, NGF, CXCL10 GOTERM_B GO:0048246~macrophage 4 0.085088279089555 2.03803723558551E-06 CCL3, CCL2, LGALS3, CX3CL1 39 12 17535 149.8717948717940 1.39101249441686E-03 5.56776839560901E-05 3.06332638772000E-03 P_DIRECT chemotaxis GOTERM_B GO:0010332~response to gamma 5 0.106360348861944 2.86582265534057E-06 CXCL1, CCL2, CXCL2, CCL7, CXCL10 39 46 17535 48.8712374581939 1.95544529908275E-03 7.52802308509048E-05 4.30752639213327E-03 P_DIRECT radiation GOTERM_B GO:0043117~positive regulation 4 0.085088279089555 3.36194041985019E-06 FGFBP3, VEGFB, VEGFA, CCL4 39 14 17535 128.4615384615380 2.29357489500392E-03 8.50411677433271E-05 5.05320755185279E-03 P_DIRECT of vascular permeability GOTERM_B GO:0007568~aging 8 0.170176558179110 4.41879061868187E-06 CCL2, NTRK1, VEGFA, GFRA1, CX3CL1, 39 315 17535 11.4188034188034 3.01349095407843E-03 1.07781357621239E-04 6.64167051837027E-03 P_DIRECT CCL5, TIMP1, NGF GOTERM_B GO:0048485~sympathetic nervous 4 0.085088279089555 5.15674901474949E-06 NRP1, NTRK1, GDNF, GFRA3 39 16 17535 112.4038461538460 3.51587344996240E-03 1.21443268559784E-04 7.75081997449467E-03 P_DIRECT system development GOTERM_B GO:0050930~induction of positive 4 0.085088279089555 6.25239781737144E-06 VEGFB, PGF, VEGFA, AGER 39 17 17535 105.7918552036190 4.26129586235857E-03 1.42336571169021E-04 9.39755595230629E-03 P_DIRECT chemotaxis GOTERM_B GO:0021675~nerve development 4 0.085088279089555 1.04349873064410E-05 NRP2, NRTN, NRP1, NGFR 39 20 17535 89.9230769230769 7.10179573106761E-03 2.29881106067586E-04 1.56836629010004E-02 P_DIRECT GOTERM_B GO:0046579~positive regulation 4 0.085088279089555 1.40542464011387E-05 HRAS, NTRK1, KITLG, NGF 39 22 17535 81.7482517482517 9.55319327780690E-03 2.99927442340974E-04 2.11228303288346E-02 P_DIRECT of Ras protein signal transduction GOTERM_B GO:0007411~axon guidance 6 0.127632418634333 1.40576352529916E-05 NRP2, NRP1, NTRK1, GAS1, NGFR, 39 144 17535 18.7339743589743 9.55548578151566E-03 2.90910173325942E-04 2.11279231016270E-02 P_DIRECT GFRA3 GOTERM_B GO:0042493~response to drug 9 0.191448627951499 1.41272103010331E-05 VEGFB, ICAM1, CCL3, CCL2, PGF, 39 528 17535 7.6638986013986 9.60255100995799E-03 2.83752463833608E-04 2.12324805576868E-02 P_DIRECT NTRK1, LGALS1, CCL5, NGF GOTERM_B GO:0001666~response to hypoxia 7 0.148904488406721 2.30100661149659E-05 VEGFB, ICAM1, CCL2, PGF, VEGFA, 39 270 17535 11.6566951566951 1.55932031923493E-02 4.48929371638984E-04 3.45808073191067E-02 P_DIRECT CX3CL1, AGER GOTERM_B GO:0048661~positive regulation 5 0.106360348861944 3.04720206923024E-05 VEGFA, IL13, CX3CL1, CCL5, AGER 39 83 17535 27.0852641334569 2.05976176292694E-02 5.77963671199888E-04 4.57926505701089E-02 P_DIRECT of smooth muscle cell proliferation GOTERM_B GO:0007267~cell-cell signaling 5 0.106360348861944 3.34716987558325E-05 CCL12, CCL3, CCL5, FGFBP1, NGF 39 85 17535 26.4479638009049 2.26022076643324E-02 6.17688958603923E-04 5.02994391795574E-02 P_DIRECT GOTERM_B GO:2001240~negative regulation 4 0.0850882790895554 0.0000638098147261273 GFRAL, CX3CL1, GAS1, GDNF 39 36 17535 49.9572649572649 0.0426473824455921 0.00114627657515742 0.0958694963772877 P_DIRECT of extrinsic apoptotic signaling pathway in absence of ligand GOTERM_B GO:0007399~nervous system 6 0.127632418634333 6.62733687310954E-05 NRP1, NTRK1, VEGFA, GFRA1, GDNF, 39 199 17535 13.5562427522226 4.42569811800735E-02 1.15999875331285E-03 9.95690821890660E-02 P_DIRECT development GFRA2 GOTERM_B GO:0050731~positive regulation 5 0.1063603488619440 0.0000684225920198120 VEGFB, ICAM1, NRP1, VEGFA, KITLG 39 102 17535 22.0399698340874 0.0456590001461594 0.00116767346833523 0.1027965245941620 P_DIRECT of peptidyl-tyrosine phosphorylation GOTERM_B GO:2001200~positive regulation 3 0.063816209317167 9.53771099307015E-05 LGALS3, LGALS1, AGER 39 7 17535 192.6923076923070 6.30690319545413E-02 1.58765718639519E-03 1.43265280600191E-01 P_DIRECT of dendritic cell differentiation GOTERM_B GO:0043066~negative regulation 8 0.170176558179110 1.06118469344833E-04 VEGFB, LGALS3, VEGFA, KITLG, GAS1, 39 517 17535 6.9572980211278 6.99182193426916E-02 1.72429171010957E-03 1.59387791178133E-01 P_DIRECT of apoptotic process NGFR, TIMP1, NGF GOTERM_B GO:0071407~cellular response to 5 0.106360348861944 1.37106115025465E-04 CCL3, CCL2, LGALS1, CCL5, AGER 39 122 17535 18.4268600252206 8.93984889622370E-02 2.17553466094921E-03 2.05885853214859E-01 P_DIRECT organic cyclic compound GOTERM_B GO:0001755~neural crest cell 4 0.085088279089555 1.61484875638204E-04 NRP2, NRTN, KITLG, GDNF 39 49 17535 36.7032967032967 1.04437329784503E-01 2.50374848103762E-03 2.42452840442586E-01 P_DIRECT migration GOTERM_B GO:1901215~negative regulation 4 0.085088279089555 2.40435391844970E-04 NTRK1, VEGFA, IL13, CCL5 39 56 17535 32.1153846153846 1.51459205957588E-01 3.64306161518324E-03 3.60789054892896E-01 P_DIRECT of neuron death GOTERM_B GO:0045785~positive regulation 4 0.085088279089555 2.53414041084594E-04 CCL2, VEGFA, CX3CL1, CCL5 39 57 17535 31.5519568151147 1.58949627162526E-01 3.75605276496970E-03 3.80229760423178E-01 P_DIRECT of cell adhesion GOTERM_B GO:0031175~neuron projection 5 0.106360348861944 2.73186432468527E-04 NRTN, GFRA1, GDNF, AGER, NGF 39 146 17535 15.3977871443624 1.70234231334263E-01 3.96259247811381E-03 4.09839999565952E-01 P_DIRECT development GOTERM_B GO:0071549~cellular response to 4 0.085088279089555 2.80712945069213E-04 ICAM1, CCL2, VEGFA, GDNF 39 59 17535 30.4823989569752 1.74489962696547E-01 3.98690312715255E-03 4.21109205411929E-01 P_DIRECT dexamethasone stimulus GOTERM_B GO:0060326~cell chemotaxis 4 0.085088279089555 2.95046270848546E-04 CXCL1, VEGFA, CCL4, CCL17 39 60 17535 29.9743589743589 1.82534302388592E-01 4.10474297296015E-03 4.42566742416927E-01 P_DIRECT GOTERM_B GO:0043922~negative regulation 3 0.063816209317167 2.97712475046405E-04 CCL3, CCL5, CCL4 39 12 17535 112.4038461538460 1.84022007648016E-01 4.05909739392718E-03 4.46557675962833E-01 P_DIRECT by host of viral transcription GOTERM_B GO:0006935~chemotaxis 4 0.085088279089555 3.57089137148552E-04 CCL1, CCL3, CX3CL1, CXCL10 39 64 17535 28.1009615384615 2.16461779488271E-01 4.77162721930757E-03 5.35397520390690E-01 P_DIRECT GOTERM_B GO:0010759~positive regulation 3 0.063816209317167 4.09360865399082E-04 CCL2, CX3CL1, CCL5 39 14 17535 96.3461538461538 2.43952227758010E-01 5.36346333915571E-03 6.13545647867253E-01 P_DIRECT of macrophage chemotaxis GOTERM_B GO:0071222~cellular response to 5 0.106360348861944 4.55064943513648E-04 ICAM1, CCL2, CXCL2, CCL5, CXCL10 39 167 17535 13.4615384615384 2.67198264346935E-01 5.84849279929899E-03 6.81827931108280E-01 P_DIRECT lipopolysaccharide GOTERM_B GO:0001938~positive regulation 4 0.085088279089555 4.64975340289031E-04 VEGFB, CCL2, PGF, VEGFA 39 70 17535 25.6923076923076 2.72143971445922E-01 5.86517698866706E-03 6.96628370062957E-01 P_DIRECT of endothelial cell proliferation GOTERM_B GO:0030595~leukocyte 3 0.063816209317167 4.71693900514774E-04 CCL3, CXCL2, CCL4 39 15 17535 89.9230769230769 2.75477846495175E-01 5.84183229665935E-03 7.06660868010744E-01 P_DIRECT chemotaxis GOTERM_B GO:0050679~positive regulation 4 0.085088279089555 6.14896751391621E-04 HRAS, VEGFA, GAS1, CCL5 39 77 17535 23.3566433566433 3.43021282598651E-01 7.47378232426432E-03 9.20273822425632E-01 P_DIRECT of epithelial cell proliferation GOTERM_B GO:0001525~angiogenesis 5 0.106360348861944 6.55413558728975E-04 NRP2, VEGFB, CCL12, NRP1, VEGFA 39 184 17535 12.2178093645484 3.60963829815655E-01 7.82526095610669E-03 9.80634067081387E-01 P_DIRECT GOTERM_B GO:0001934~positive regulation 5 0.106360348861944 6.68862252912821E-04 HRAS, NTRK1, VEGFA, AGER, NGF 39 185 17535 12.1517671517671 3.66810647213741E-01 7.84810646103229E-03 1.00066178012112E+00 P_DIRECT of protein phosphorylation GOTERM_B GO:0090026~positive regulation 3 0.063816209317167 6.84511816713310E-04 CCL2, CCL5, CXCL10 39 18 17535 74.9358974358974 3.73547080486953E-01 7.89547343492269E-03 1.02396225453270E+00 P_DIRECT of monocyte chemotaxis GOTERM_B GO:0009611~response to 4 0.085088279089555 6.87550063444643E-04 CCL2, NRP1, NGFR, GDNF 39 80 17535 22.4807692307692 3.74846589762829E-01 7.79873421781029E-03 1.02848527537029E+00 P_DIRECT wounding GOTERM_B GO:0071333~cellular response to 4 0.085088279089555 9.37680135347203E-04 ICAM1, CCL2, LGALS1, AGER 39 89 17535 20.2074330164217 4.73095510974889E-01 1.04488955765528E-02 1.40019141583469E+00 P_DIRECT glucose stimulus GOTERM_B GO:0002687~positive regulation 3 0.063816209317167 1.02784428138903E-03 CCL12, CCL2, KITLG 39 22 17535 61.3111888111888 5.04594507014882E-01 1.12647603356256E-02 1.53386013442031E+00 P_DIRECT of leukocyte migration GOTERM_B GO:0014823~response to activity 4 0.085088279089555 1.03226669253921E-03 CCL2, NTRK1, CCL5, AGER 39 92 17535 19.5484949832775 5.06090163333559E-01 1.11344102775432E-02 1.54041202332430E+00 P_DIRECT GOTERM_B GO:0035924~cellular response to 3 0.0638162093171665 0.00112419724058253 NRP1, VEGFA, GAS1 39 23 17535 58.6454849498327 0.536179953774703 0.011932280072807 1.67651681295377 P_DIRECT vascular endothelial growth factor stimulus GOTERM_B GO:0010628~positive regulation 6 0.127632418634333 1.16648126182960E-03 HRAS, CCL3, VEGFA, CCL5, AGER, NGF 39 371 17535 7.2714078374456 5.49398415793682E-01 1.21892819821491E-02 1.73906006236621E+00 P_DIRECT of gene expression GOTERM_B GO:0035690~cellular response to 4 0.085088279089555 1.20295633024413E-03 CCL2, VEGFA, CCL4, AGER 39 97 17535 18.5408406026962 5.60498327423960E-01 1.23790108303646E-02 1.79298132213713E+00 P_DIRECT drug GOTERM_B GO:0006874~cellular calcium ion 4 0.085088279089555 1.20295633024413E-03 CCL12, CCL3, CCL2, CCL5 39 97 17535 18.5408406026962 5.60498327423960E-01 1.23790108303646E-02 1.79298132213713E+00 P_DIRECT homeostasis GOTERM_B GO:0031663~lipopolysaccharide- 3 0.063816209317167 2.04376490769690E-03 CCL3, CCL2, CCL5 39 31 17535 43.5111662531017 7.52741224189613E-01 2.06395472946672E-02 3.02832197700969E+00 P_DIRECT mediated signaling pathway GOTERM_B GO:0051928~positive regulation 3 0.063816209317167 2.04376490769690E-03 CCL3, CCL5, CCL4 39 31 17535 43.5111662531017 7.52741224189613E-01 2.06395472946672E-02 3.02832197700969E+00 P_DIRECT of calcium ion transport GOTERM_B GO:0042060~wound healing 4 0.085088279089555 2.54349386139697E-03 VEGFA, CXCL2, CX3CL1, TIMP1 39 126 17535 14.2735042735042 8.24377653426982E-01 2.52553076622552E-02 3.75564987606165E+00 P_DIRECT GOTERM_B GO:0007010~cytoskeleton 4 0.085088279089555 2.65962536859677E-03 CCL12, CCL3, CCL2, CCL7 39 128 17535 14.0504807692307 8.37803068464686E-01 2.60170767076085E-02 3.92394208484226E+00 P_DIRECT organization GOTERM_B GO:0051781~positive regulation 3 0.063816209317167 2.90333718203512E-03 VEGFB, PGF, VEGFA 39 37 17535 36.4553014553014 8.62737963938973E-01 2.79708436101925E-02 4.27622481736968E+00 P_DIRECT of cell division GOTERM_B GO:0043491~protein kinase B 3 0.063816209317167 2.90333718203512E-03 CCL3, CCL2, CCL5 39 37 17535 36.4553014553014 8.62737963938973E-01 2.79708436101925E-02 4.27622481736968E+00 P_DIRECT signaling GOTERM_B GO:0007186~G-protein coupled 12 0.2552648372686660 0.00304413048903890 CXCL1, CCL1, CCL12, CCL3, CCL2, 39 2034 17535 2.6525981393238 0.875358311437612 0.028902438187299 4.47919010403966 P_DIRECT receptor signaling pathway CXCL2, CX3CL1, CCL5, CCL4, CCL7, CCL17, CXCL10 GOTERM_B GO:0010976~positive regulation 4 0.085088279089555 3.42537543094839E-03 NTRK1, CX3CL1, NGFR, NGF 39 140 17535 12.8461538461538 9.04013476703012E-01 3.20252439934843E-02 5.02677161000719E+00 P_DIRECT of neuron projection development GOTERM_B GO:0044344~cellular response to 3 0.063816209317167 3.72791725886276E-03 CCL2, VEGFA, CCL5 39 42 17535 32.1153846153846 9.21990546954829E-01 3.43406838203808E-02 5.45922514871770E+00 P_DIRECT fibroblast growth factor stimulus GOTERM_B GO:0021649~vestibulocochlear 2 0.042544139544778 4.32961579325350E-03 NRP2, NRP1 39 2 17535 449.6153846153840 9.48364597037738E-01 3.92566222981980E-02 6.31383587343655E+00 P_DIRECT nerve structural organization GOTERM_B GO:0090259~regulation of retinal 2 0.042544139544778 4.32961579325350E-03 NRP1, VEGFA 39 2 17535 449.6153846153840 9.48364597037738E-01 3.92566222981980E-02 6.31383587343655E+00 P_DIRECT ganglion cell axon guidance GOTERM_B GO:1904835~dorsal root ganglion 2 0.042544139544778 4.32961579325350E-03 NRP2, NRP1 39 2 17535 449.6153846153840 9.48364597037738E-01 3.92566222981980E-02 6.31383587343655E+00 P_DIRECT morphogenesis GOTERM_B GO:0071403~cellular response to 2 0.0425441395447777 0.00432961579325350 CCL2, CCL5 39 2 17535 449.6153846153840 0.948364597037738 0.039256622298198 6.31383587343655 P_DIRECT high density lipoprotein particle stimulus GOTERM_B GO:0001975~response to 3 0.063816209317167 4.45693978119642E-03 CXCL1, ICAM1, CXCL2 39 46 17535 29.3227424749163 9.52683384071666E-01 3.98623154782363E-02 6.49375108895818E+00 P_DIRECT amphetamine GOTERM_B GO:0043406~positive regulation 3 0.063816209317167 6.31687673300189E-03 HRAS, VEGFA, KITLG 39 55 17535 24.5244755244755 9.86807559715283E-01 5.53575974908153E-02 9.08544005404456E+00 P_DIRECT of MAP kinase activity GOTERM_B GO:0097374~sensory neuron axon 2 0.042544139544778 6.48757362174176E-03 NRP2, NRP1 39 3 17535 299.7435897435890 9.88268157040231E-01 5.60981564933786E-02 9.31990352563767E+00 P_DIRECT guidance GOTERM_B GO:0021828~gonadotrophin- 2 0.0425441395447777 0.00648757362174176 NRP2, NRP1 39 3 17535 299.7435897435890 0.988268157040231 0.056098156493379 9.31990352563767 P_DIRECT releasing hormone neuronal migration to the hypothalamus GOTERM_B GO:1903375~facioacoustic 2 0.042544139544778 6.48757362174176E-03 NRP2, NRP1 39 3 17535 299.7435897435890 9.88268157040231E-01 5.60981564933786E-02 9.31990352563767E+00 P_DIRECT ganglion development GOTERM_B GO:0032760~positive regulation 3 0.063816209317167 6.54193011569472E-03 CCL3, CCL2, CCL4 39 56 17535 24.0865384615384 9.88698473210825E-01 5.58516913615015E-02 9.39444719846804E+00 P_DIRECT of tumor necrosis factor GOTERM_B GO:0007265~Rasproduction protein signal 3 0.063816209317167 7.00288077500998E-03 HRAS, NTRK1, NGF 39 58 17535 23.2559681697612 9.91768552873655E-01 5.89479985683124E-02 1.00242925972271E+01 P_DIRECT transduction GOTERM_B GO:0001541~ovarian follicle 3 0.063816209317167 7.72117882483729E-03 ICAM1, VEGFA, KITLG 39 61 17535 22.1122320302648 9.94978515214898E-01 6.40332907602160E-02 1.09976374414781E+01 P_DIRECT development GOTERM_B GO:0045471~response to ethanol 4 0.085088279089555 8.34485869692967E-03 ICAM1, CCL2, NTRK1, IL13 39 193 17535 9.3184535671582 9.96731592919821E-01 6.82212712171772E-02 1.18347867216728E+01 P_DIRECT GOTERM_B GO:0035094~response to nicotine 3 0.063816209317167 8.47134569299188E-03 NTRK1, IL13, NGF 39 64 17535 21.0757211538461 9.97004295060693E-01 6.84083269143613E-02 1.20036679034844E+01 P_DIRECT GOTERM_B GO:0060688~regulation of 2 0.0425441395447777 0.00864097723793658 PGF, GDNF 39 4 17535 224.8076923076920 0.997334687336718 0.068924459910328 12.22968022303120 P_DIRECT morphogenesis of a branching structure GOTERM_B GO:0036486~ventral trunk neural 2 0.042544139544778 8.64097723793658E-03 NRP2, NRP1 39 4 17535 224.8076923076920 9.97334687336718E-01 6.89244599103280E-02 1.22296802230312E+01 P_DIRECT crest cell migration GOTERM_B GO:1902285~semaphorin-plexin 2 0.0425441395447777 0.00864097723793658 NRP2, NRP1 39 4 17535 224.8076923076920 0.997334687336718 0.068924459910328 12.22968022303120 P_DIRECT signaling pathway involved in neuron projection guidance GOTERM_B GO:0035860~glial cell-derived 2 0.0425441395447777 0.00864097723793658 GFRA4, GFRA2 39 4 17535 224.8076923076920 0.997334687336718 0.068924459910328 12.22968022303120 P_DIRECT neurotrophic factor receptor signaling pathway GOTERM_B GO:0097491~sympathetic neuron 2 0.042544139544778 8.64097723793658E-03 NRP2, NRP1 39 4 17535 224.8076923076920 9.97334687336718E-01 6.89244599103280E-02 1.22296802230312E+01 P_DIRECT projection guidance GOTERM_B GO:0097490~sympathetic neuron 2 0.042544139544778 8.64097723793658E-03 NRP2, NRP1 39 4 17535 224.8076923076920 9.97334687336718E-01 6.89244599103280E-02 1.22296802230312E+01 P_DIRECT projection extension GOTERM_B GO:0045185~maintenance of 2 0.042544139544778 8.64097723793658E-03 LGALS3, LGALS1 39 4 17535 224.8076923076920 9.97334687336718E-01 6.89244599103280E-02 1.22296802230312E+01 P_DIRECT protein location GOTERM_B GO:0016525~negative regulation 3 0.063816209317167 8.98895363679988E-03 CCL2, NGFR, CXCL10 39 66 17535 20.4370629370629 9.97902932744058E-01 7.07888063458616E-02 1.26916193353650E+01 P_DIRECT of angiogenesis GOTERM_B GO:0010629~negative regulation 4 0.085088279089555 1.07683058386495E-02 VEGFB, HRAS, CCL3, VEGFA 39 212 17535 8.4833091436865 9.99385461264281E-01 8.33190068070276E-02 1.50184483372479E+01 P_DIRECT of gene expression GOTERM_B GO:0061551~trigeminal ganglion 2 0.042544139544778 1.07898359946973E-02 NRP2, NRP1 39 5 17535 179.8461538461530 9.99394529021437E-01 8.25498403106168E-02 1.50462451414527E+01 P_DIRECT development GOTERM_B GO:1901166~neural crest cell 2 0.0425441395447777 0.0107898359946973 NRP2, NRP1 39 5 17535 179.846153846153 0.999394529021437 0.0825498403106168 15.0462451414527 P_DIRECT migration involved in autonomic nervous system development GOTERM_B GO:0060978~angiogenesis 2 0.0425441395447777 0.0107898359946973 NRP1, VEGFA 39 5 17535 179.846153846153 0.999394529021437 0.0825498403106168 15.0462451414527 P_DIRECT involved in coronary vascular morphogenesis GOTERM_B GO:0009408~response to heat 3 0.063816209317167 1.23812264790673E-02 CXCL1, CCL2, CXCL2 39 78 17535 17.2928994082840 9.99798387699183E-01 9.31756271537249E-02 1.70774943969210E+01 P_DIRECT GOTERM_B GO:1902035~positive regulation 2 0.0425441395447777 0.0129341592250759 CXCL1, KITLG 39 6 17535 149.871794871794 0.999862468638318 0.0961045471629414 17.7725791573550 P_DIRECT of hematopoietic stem cell proliferation GOTERM_B GO:0002693~positive regulation 2 0.042544139544778 1.29341592250759E-02 ICAM1, CCL2 39 6 17535 149.8717948717940 9.99862468638318E-01 9.61045471629414E-02 1.77725791573550E+01 P_DIRECT of cellular extravasation GOTERM_B GO:0060385~axonogenesis 2 0.042544139544778 1.29341592250759E-02 NRP1, NTRK1 39 6 17535 149.8717948717940 9.99862468638318E-01 9.61045471629414E-02 1.77725791573550E+01 P_DIRECT involved in innervation GOTERM_B GO:0010818~T cell chemotaxis 2 0.042544139544778 1.29341592250759E-02 CCL3, CXCL10 39 6 17535 149.8717948717940 9.99862468638318E-01 9.61045471629414E-02 1.77725791573550E+01 P_DIRECT GOTERM_B GO:0019233~sensory perception 3 0.063816209317167 1.29932447287954E-02 NTRK1, NGFR, NGF 39 80 17535 16.8605769230769 9.99867978267322E-01 9.54933870479485E-02 1.78465322744696E+01 P_DIRECT of pain GOTERM_B GO:0007169~transmembrane 3 0.0638162093171665 0.0139356229177960 NRTN, NTRK1, GFRA2 39 83 17535 16.251158480074 0.999931245814668 0.1010246816040970 19.0176799664330 P_DIRECT receptor protein tyrosine kinase signaling pathway GOTERM_B GO:0051897~positive regulation 3 0.063816209317167 1.45799372701345E-02 VEGFB, CCL3, NGFR 39 85 17535 15.8687782805429 9.99956003689996E-01 1.04376555775522E-01 1.98094159292687E+01 P_DIRECT of protein kinase B signaling GOTERM_B GO:0043615~astrocyte cell 2 0.042544139544778 1.50739562444176E-02 CCL3, CCL2 39 7 17535 128.4615384615380 9.99968762706875E-01 1.06634743248264E-01 2.04115679831979E+01 P_DIRECT migration GOTERM_B GO:0038084~vascular endothelial 2 0.042544139544778 1.50739562444176E-02 NRP2, VEGFA 39 7 17535 128.4615384615380 9.99968762706875E-01 1.06634743248264E-01 2.04115679831979E+01 P_DIRECT growth factor signaling pathway GOTERM_B GO:0045743~positive regulation 2 0.0425441395447777 0.0150739562444176 FGFBP3, FGFBP1 39 7 17535 128.461538461538 0.999968762706875 0.1066347432482640 20.4115679831979 P_DIRECT of fibroblast growth factor receptor signaling pathway GOTERM_B GO:0048842~positive regulation 2 0.0425441395447777 0.0150739562444176 NRP1, VEGFA 39 7 17535 128.461538461538 0.999968762706875 0.1066347432482640 20.4115679831979 P_DIRECT of axon extension involved in axon guidance GOTERM_B GO:0006887~exocytosis 3 0.063816209317167 1.55702101537041E-02 CCL12, CCL3, CCL5 39 88 17535 15.3277972027972 9.99977859751586E-01 1.08855360950541E-01 2.10121926455399E+01 P_DIRECT GOTERM_B GO:0006816~calcium ion 3 0.063816209317167 1.69343957277816E-02 CCL12, CCL3, CCL5 39 92 17535 14.6613712374581 9.99991412864809E-01 1.16707039788903E-01 2.26415596009576E+01 P_DIRECT transport GOTERM_B GO:0071679~commissural neuron 2 0.042544139544778 1.72092363483400E-02 NRP1, VEGFA 39 8 17535 112.4038461538460 9.99992905720783E-01 1.17328641589493E-01 2.29660051978444E+01 P_DIRECT axon guidance GOTERM_B GO:0000165~MAPK cascade 3 0.063816209317167 1.87087678571400E-02 CCL3, CCL2, CCL5 39 97 17535 13.9056304520222 9.99997499779630E-01 1.25729937468334E-01 2.47139249839843E+01 P_DIRECT GOTERM_B GO:0038180~nerve growth factor 2 0.042544139544778 1.93400088157531E-02 NTRK1, NGF 39 9 17535 99.9145299145299 9.99998388959746E-01 1.28475807070145E-01 2.54385951866706E+01 P_DIRECT signaling pathway GOTERM_B GO:0061549~sympathetic 2 0.042544139544778 1.93400088157531E-02 NRP2, NRP1 39 9 17535 99.9145299145299 9.99998388959746E-01 1.28475807070145E-01 2.54385951866706E+01 P_DIRECT ganglion development GOTERM_B GO:0035767~endothelial cell 2 0.042544139544778 1.93400088157531E-02 NRP1, VEGFA 39 9 17535 99.9145299145299 9.99998388959746E-01 1.28475807070145E-01 2.54385951866706E+01 P_DIRECT chemotaxis GOTERM_B GO:0045666~positive regulation 3 0.063816209317167 2.09370922655658E-02 NGFR, CCL5, NGF 39 103 17535 13.0955937266616 9.99999470777814E-01 1.37109892263238E-01 2.72430891289426E+01 P_DIRECT of neuron differentiation GOTERM_B GO:0009612~response to 3 0.063816209317167 2.13187928774921E-02 CCL2, IL13, NGF 39 104 17535 12.9696745562130 9.99999594516631E-01 1.38145266579208E-01 2.76682824494559E+01 P_DIRECT mechanical stimulus GOTERM_B GO:0042088~T-helper 1 type 2 0.042544139544778 2.14662829020733E-02 HRAS, VEGFA 39 10 17535 89.9230769230769 9.99999634179757E-01 1.37751043745368E-01 2.78319559767397E+01 P_DIRECT immune response GOTERM_B GO:0035900~response to isolation 2 0.042544139544778 2.14662829020733E-02 HRAS, LGALS1 39 10 17535 89.9230769230769 9.99999634179757E-01 1.37751043745368E-01 2.78319559767397E+01 P_DIRECT stress GOTERM_B GO:0021612~facial nerve 2 0.042544139544778 2.14662829020733E-02 NRP2, NRP1 39 10 17535 89.9230769230769 9.99999634179757E-01 1.37751043745368E-01 2.78319559767397E+01 P_DIRECT structural organization GOTERM_B GO:0030949~positive regulation 2 0.0425441395447777 0.0235880678528333 VEGFB, VEGFA 39 11 17535 81.7482517482517 0.999999916939929 0.149067770259054 30.1486220048321 P_DIRECT of vascular endothelial growth factor receptor signaling pathway GOTERM_B GO:0051092~positive regulation 3 0.0638162093171665 0.0261222832488664 ICAM1, NTRK1, AGER 39 116 17535 11.6279840848806 0.999999985922519 0.162422978583315 32.8245982462625 P_DIRECT of NF-kappaB transcription factor activity GOTERM_B GO:0009636~response to toxic 3 0.063816209317167 2.73858941342225E-02 CCL3, CCL5, CCL4 39 119 17535 11.3348416289592 9.99999994200305E-01 1.68172910803509E-01 3.41228461806938E+01 P_DIRECT substance GOTERM_B GO:0048846~axon extension 2 0.042544139544778 2.78182072093974E-02 NRP2, NRP1 39 13 17535 69.1715976331361 9.99999995719139E-01 1.69128327356690E-01 3.45616053955280E+01 P_DIRECT involved in axon guidance GOTERM_B GO:0002544~chronic 2 0.042544139544778 2.78182072093974E-02 CCL2, CCL5 39 13 17535 69.1715976331361 9.99999995719139E-01 1.69128327356690E-01 3.45616053955280E+01 P_DIRECT inflammatory response GOTERM_B GO:0070723~response to 2 0.042544139544778 2.78182072093974E-02 CCL3, CCL5 39 13 17535 69.1715976331361 9.99999995719139E-01 1.69128327356690E-01 3.45616053955280E+01 P_DIRECT cholesterol GOTERM_B GO:0007623~circadian rhythm 3 0.063816209317167 2.82418678490909E-02 NTRK1, NGFR, NGF 39 121 17535 11.1474888747616 9.99999996821373E-01 1.70017477268492E-01 3.49889353942986E+01 P_DIRECT GOTERM_B GO:0001764~neuron migration 3 0.063816209317167 2.95459172948697E-02 NRP2, NRP1, GFRA3 39 124 17535 10.8777915632754 9.99999998729662E-01 1.75720101274523E-01 3.62879872261012E+01 P_DIRECT GOTERM_B GO:2000406~positive regulation 2 0.042544139544778 2.99265800056633E-02 CCL5, CXCL10 39 14 17535 64.2307692307692 9.99999999028270E-01 1.76295476217961E-01 3.66625971855087E+01 P_DIRECT of T cell migration GOTERM_B GO:0001775~cell activation 2 0.042544139544778 2.99265800056633E-02 CCL3, TIMP1 39 14 17535 64.2307692307692 9.99999999028270E-01 1.76295476217961E-01 3.66625971855087E+01 P_DIRECT GOTERM_B GO:0002523~leukocyte migration 2 0.042544139544778 2.99265800056633E-02 CCL2, CX3CL1 39 14 17535 64.2307692307692 9.99999999028270E-01 1.76295476217961E-01 3.66625971855087E+01 P_DIRECT involved in inflammatory response GOTERM_B GO:0090303~positive regulation 2 0.042544139544778 3.20305004412560E-02 HRAS, CCL2 39 15 17535 59.9487179487179 9.99999999779442E-01 1.86067906836659E-01 3.86962479783976E+01 P_DIRECT of wound healing GOTERM_B GO:0071456~cellular response to 3 0.063816209317167 3.54673603206016E-02 ICAM1, S100B, VEGFA 39 137 17535 9.8455923638405 9.99999999980570E-01 2.02503084524855E-01 4.18877044813831E+01 P_DIRECT hypoxia GOTERM_B GO:0031954~positive regulation 2 0.042544139544778 3.62250208111012E-02 VEGFA, NGF 39 17 17535 52.8959276018099 9.99999999988640E-01 2.04750623637175E-01 4.25700767465847E+01 P_DIRECT of protein autophosphorylation GOTERM_B GO:0001774~microglial cell 2 0.042544139544778 3.62250208111012E-02 IL13, CX3CL1 39 17 17535 52.8959276018099 9.99999999988640E-01 2.04750623637175E-01 4.25700767465847E+01 P_DIRECT activation GOTERM_B GO:0002042~cell migration 2 0.042544139544778 3.62250208111012E-02 NRP1, VEGFA 39 17 17535 52.8959276018099 9.99999999988640E-01 2.04750623637175E-01 4.25700767465847E+01 P_DIRECT involved in sprouting angiogenesis GOTERM_B GO:0043065~positive regulation 4 0.085088279089555 3.64398838587453E-02 S100B, NGFR, AGER, NGF 39 338 17535 5.3208921256259 9.99999999990244E-01 2.04200097621459E-01 4.27622232852959E+01 P_DIRECT of apoptotic process GOTERM_B GO:0090280~positive regulation 2 0.042544139544778 3.83156389880207E-02 CCL2, LGALS3 39 18 17535 49.9572649572649 9.99999999997422E-01 2.11995176647971E-01 4.44143599276875E+01 P_DIRECT of calcium ion import GOTERM_B GO:0008584~male gonad 3 0.063816209317167 4.03089927792951E-02 KITLG, GFRA1, GDNF 39 147 17535 9.1758241758242 9.99999999999375E-01 2.20173648226350E-01 4.61212182606215E+01 P_DIRECT development GOTERM_B GO:0048255~mRNA stabilization 2 0.042544139544778 4.04018412890819E-02 VEGFA, GDNF 39 19 17535 47.3279352226720 9.99999999999415E-01 2.18923545407214E-01 4.61995168429430E+01 P_DIRECT GOTERM_B GO:0048011~neurotrophin TRK 2 0.042544139544778 4.45610345552208E-02 NTRK1, NGF 39 21 17535 42.8205128205128 9.99999999999969E-01 2.37178838902204E-01 4.95999607156613E+01 P_DIRECT receptor signaling pathway GOTERM_B GO:0007204~positive regulation 3 0.0638162093171665 0.0448684733129058 CXCL1, CCL3, CXCL2 39 156 17535 8.64644970414201 0.999999999999975 0.236843898291179 49.84317763601 P_DIRECT of cytosolic calcium ion concentration GOTERM_B GO:0050850~positive regulation 2 0.042544139544778 4.87026729928073E-02 CCL3, CCL4 39 23 17535 39.0969899665551 9.99999999999998E-01 2.52830823826183E-01 5.27858329336680E+01 P_DIRECT of calcium-mediated signaling GOTERM_B GO:0045672~positive regulation 2 0.042544139544778 4.87026729928073E-02 CCL3, CCL5 39 23 17535 39.0969899665551 9.99999999999998E-01 2.52830823826183E-01 5.27858329336680E+01 P_DIRECT of osteoclast differentiation GOTERM_B GO:0090190~positive regulation 2 0.0425441395447777 0.0487026729928073 VEGFA, GDNF 39 23 17535 39.09698996655510 0.999999999999998 0.252830823826183 52.78583293367 P_DIRECT of branching involved in ureteric bud morphogenesis GOTERM_B GO:0007422~peripheral nervous 2 0.042544139544778 4.87026729928073E-02 GDNF, NGF 39 23 17535 39.0969899665551 9.99999999999998E-01 2.52830823826183E-01 5.27858329336680E+01 P_DIRECT system development GOTERM_B GO:0007159~leukocyte cell-cell 2 0.042544139544778 5.28268287121402E-02 ICAM1, CCL5 39 25 17535 35.9692307692307 9.99999999999999E-01 2.69584295015238E-01 5.57706509633710E+01 P_DIRECT adhesion GOTERM_B GO:0048844~artery 2 0.042544139544778 5.28268287121402E-02 NRP1, VEGFA 39 25 17535 35.9692307692307 9.99999999999999E-01 2.69584295015238E-01 5.57706509633710E+01 P_DIRECT morphogenesis GOTERM_B GO:0090023~positive regulation 2 0.042544139544778 5.28268287121402E-02 CXCL1, CXCL2 39 25 17535 35.9692307692307 9.99999999999999E-01 2.69584295015238E-01 5.57706509633710E+01 P_DIRECT of neutrophil chemotaxis GOTERM_B GO:0071361~cellular response to 2 0.042544139544778 5.48823730009810E-02 CCL5, CCL7 39 26 17535 34.5857988165680 1.00000000000000E+00 2.76728730108511E-01 5.71916549108671E+01 P_DIRECT ethanol GOTERM_B GO:0045662~negative regulation 2 0.042544139544778 5.48823730009810E-02 CCL17, CXCL10 39 26 17535 34.5857988165680 1.00000000000000E+00 2.76728730108511E-01 5.71916549108671E+01 P_DIRECT of myoblast differentiation GOTERM_B GO:0002052~positive regulation 2 0.042544139544778 5.48823730009810E-02 VEGFA, CX3CL1 39 26 17535 34.5857988165680 1.00000000000000E+00 2.76728730108511E-01 5.71916549108671E+01 P_DIRECT of neuroblast proliferation GOTERM_B GO:0002040~sprouting 2 0.042544139544778 5.48823730009810E-02 NRP1, PGF 39 26 17535 34.5857988165680 1.00000000000000E+00 2.76728730108511E-01 5.71916549108671E+01 P_DIRECT angiogenesis GOTERM_B GO:0051968~positive regulation 2 0.0425441395447777 0.054882373000981 NTRK1, NGFR 39 26 17535 34.585798816568 1 0.276728730108511 57.1916549108671 P_DIRECT of synaptic transmission, glutamatergic GOTERM_B GO:0050806~positive regulation 2 0.042544139544778 5.69335735181940E-02 CCL2, S100B 39 27 17535 33.3048433048433 1.00000000000000E+00 2.83686449302402E-01 5.85670820945372E+01 P_DIRECT of synaptic transmission GOTERM_B GO:0007202~activation of 2 0.042544139544778 5.89804391915061E-02 NTRK1, NGF 39 28 17535 32.1153846153846 1.00000000000000E+00 2.90464377462316E-01 5.98983918428796E+01 P_DIRECT phospholipase C activity GOTERM_B GO:0071354~cellular response to 2 0.042544139544778 5.89804391915061E-02 ICAM1, CCL2 39 28 17535 32.1153846153846 1.00000000000000E+00 2.90464377462316E-01 5.98983918428796E+01 P_DIRECT interleukin-6 GOTERM_B GO:1901216~positive regulation 2 0.042544139544778 6.30612016483711E-02 NGFR, AGER 39 30 17535 29.9743589743589 1.00000000000000E+00 3.05568798876304E-01 6.24342646141608E+01 P_DIRECT of neuron death GOTERM_B GO:2000352~negative regulation 2 0.0425441395447777 0.063061201648371 ICAM1, IL13 39 30 17535 29.974358974359 1 0.305568798876304 62.4342646141608 P_DIRECT of endothelial cell apoptotic process GOTERM_B GO:0007569~cell aging 2 0.042544139544778 6.71247314677396E-02 ICAM1, HRAS 39 32 17535 28.1009615384615 1.00000000000000E+00 3.20115720883290E-01 6.48100413940623E+01 P_DIRECT GOTERM_B GO:0071398~cellular response to 2 0.042544139544778 6.71247314677396E-02 CCL2, AGER 39 32 17535 28.1009615384615 1.00000000000000E+00 3.20115720883290E-01 6.48100413940623E+01 P_DIRECT fatty acid GOTERM_B GO:0016477~cell migration 3 0.063816209317167 6.78252786843205E-02 NRP1, VEGFA, GFRA1 39 197 17535 6.8469347910972 1.00000000000000E+00 3.20813133528500E-01 6.52051653776109E+01 P_DIRECT GOTERM_B GO:0032355~response to estradiol 3 0.063816209317167 7.02391910565054E-02 CXCL1, VEGFA, CXCL2 39 201 17535 6.7106773823192 1.00000000000000E+00 3.28292135318379E-01 6.65351715106464E+01 P_DIRECT GOTERM_B GO:0051281~positive regulation 2 0.0425441395447777 0.071171099471658 IL13, CXCL10 39 34 17535 26.447963800905 1 0.329820337819946 67.0358128445946 P_DIRECT of release of sequestered calcium ion into cytosol GOTERM_B GO:0097192~extrinsic apoptotic 2 0.0425441395447777 0.073187869836469 KITLG, NGF 39 35 17535 25.692307692308 1 0.335518381414751 68.0954251685209 P_DIRECT signaling pathway in absence of ligand GOTERM_B GO:0034612~response to tumor 2 0.042544139544778 7.31878698364685E-02 CCL2, CCL5 39 35 17535 25.6923076923076 1.00000000000000E+00 3.35518381414751E-01 6.80954251685209E+01 P_DIRECT necrosis factor GOTERM_B GO:0002053~positive regulation 2 0.042544139544778 7.52003761823632E-02 VEGFA, GAS1 39 36 17535 24.9786324786324 1.00000000000000E+00 3.41080511487218E-01 6.91210346629222E+01 P_DIRECT of mesenchymal cell proliferation GOTERM_B GO:0001569~patterning of blood 2 0.042544139544778 7.52003761823632E-02 NRP1, VEGFA 39 36 17535 24.9786324786324 1.00000000000000E+00 3.41080511487218E-01 6.91210346629222E+01 P_DIRECT vessels GOTERM_B GO:0045786~negative regulation 2 0.042544139544778 8.51992538617061E-02 NGFR, NGF 39 41 17535 21.9324577861163 1.00000000000000E+00 3.75919863353941E-01 7.37759687410818E+01 P_DIRECT of cell cycle GOTERM_B GO:0033189~response to vitamin 2 0.042544139544778 8.51992538617061E-02 VEGFA, AGER 39 41 17535 21.9324577861163 1.00000000000000E+00 3.75919863353941E-01 7.37759687410818E+01 P_DIRECT A GOTERM_B GO:0014911~positive regulation 2 0.042544139544778 8.71863596314512E-02 CCL5, AGER 39 42 17535 21.4102564102564 1.00000000000000E+00 3.80767474351593E-01 7.46192553213678E+01 P_DIRECT of smooth muscle cell migration GOTERM_B GO:2001237~negative regulation 2 0.0425441395447777 0.087186359631451 NRP1, LGALS3 39 42 17535 21.410256410256 1 0.380767474351593 74.6192553213678 P_DIRECT of extrinsic apoptotic signaling pathway GOTERM_B GO:0008283~cell proliferation 3 0.063816209317167 8.98570858097877E-02 HRAS, VEGFA, GDNF 39 232 17535 5.8139920424403 1.00000000000000E+00 3.87920228292757E-01 7.57128250970446E+01 P_DIRECT GOTERM_B GO:0071345~cellular response to 2 0.042544139544778 9.11479708513162E-02 IL13, CCL5 39 44 17535 20.4370629370629 1.00000000000000E+00 3.90135074215229E-01 7.62254811816299E+01 P_DIRECT cytokine stimulus GOTERM_B GO:0045740~positive regulation 2 0.042544139544778 9.11479708513162E-02 HRAS, KITLG 39 44 17535 20.4370629370629 1.00000000000000E+00 3.90135074215229E-01 7.62254811816299E+01 P_DIRECT of DNA replication GOTERM_B GO:0042127~regulation of cell 3 0.063816209317167 9.11742276481225E-02 CXCL1, CXCL2, CXCL10 39 234 17535 5.7642998027613 1.00000000000000E+00 3.87954077853538E-01 7.62358030815793E+01 P_DIRECT proliferation GOTERM_B GO:0007264~small GTPase 3 0.063816209317167 9.11742276481225E-02 HRAS, NTRK1, NGF 39 234 17535 5.7642998027613 1.00000000000000E+00 3.87954077853538E-01 7.62358030815793E+01 P_DIRECT mediated signal transduction GOTERM_B GO:0048678~response to axon 2 0.042544139544778 9.90210336043138E-02 NTRK1, LGALS1 39 48 17535 18.7339743589743 1.00000000000000E+00 4.12267228575801E-01 7.91398832033864E+01 P_DIRECT injury Day 28 GOTERM_B GO:0043524~negative regulation 8 0.208550573514077 4.26242114315679E-09 VEGFB, BDNF, CCL2, NTF4, NRP1, 29 158 17535 30.6154517677869 2.25055586255962E-06 2.25055586255962E-06 6.18507567384796E-06 P_DIRECT of neuron apoptotic process NTF3, GFRAL, NGF GOTERM_B GO:0070374~positive regulation 8 0.208550573514077 1.32354294603319E-08 VEGFB, CCL2, NRP1, LOC103690065, 29 186 17535 26.0066740823136 6.98828236134208E-06 3.49414728517682E-06 1.92055462977513E-05 P_DIRECT of ERK1 and ERK2 cascade CCL5, THPO, EPO GOTERM_B GO:0048011~neurotrophin TRK 5 0.130344108446298 3.05445974678434E-08 BDNF, NTF4, NTF3, SORT1, NGF 29 21 17535 143.9655172413790 1.61274176875281E-05 5.37583479542913E-06 4.43223710178131E-05 P_DIRECT receptor signaling pathway GOTERM_B GO:0008284~positive regulation 10 0.260688216892596 5.20317358765024E-08 NOTCH2, LGALS3, NTF3, PGF, GAS1, 29 503 17535 12.0209775827791 2.74723799076337E-05 6.86816573414184E-06 7.55017173781347E-05 P_DIRECT of cell proliferation TIMP1, NGF, THPO, EPO GOTERM_B GO:0042493~response to drug 9 0.234619395203336 1.17057265075096E-06 VEGFB, BDNF, CCL2, PGF, LGALS1, 29 528 17535 10.3066222570532 6.17871759893362E-04 1.23604904546881E-04 1.69857061405043E-03 P_DIRECT TIMP4, CCL5, TIMP2, NGF GOTERM_B GO:0032496~response to 7 0.182481751824817 4.40508019645850E-06 CCL2, TIMP4, CCL5, NGF, THPO, EPO 29 280 17535 15.1163793103448 2.32318468622361E-03 3.87572785359058E-04 6.39189398570216E-03 P_DIRECT lipopolysaccharide GOTERM_B GO:0048010~vascular endothelial 4 0.104275286757038 0.00000475708330819 VEGFB, CCL2, NRP1, PGF 29 21 17535 115.172413793103 0.00250859416650728 0.000358756483069599 0.00690264388540917 P_DIRECT growth factor receptor signaling pathway GOTERM_B GO:0007568~aging 7 0.182481751824817 8.64965450415136E-06 CCL2, GFRA1, CCL5, TIMP2, TIMP1, 29 315 17535 13.4367816091954 4.55662427321157E-03 5.70716745444288E-04 1.25505295885064E-02 P_DIRECT NGF, EPO GOTERM_B GO:0007202~activation of 4 0.104275286757038 1.16300554773711E-05 BDNF, NTF4, NTF3, NGF 29 28 17535 86.3793103448275 6.12188940489211E-03 6.82067841513589E-04 1.68747106156219E-02 P_DIRECT phospholipase C activity GOTERM_B GO:0050918~positive chemotaxis 4 0.104275286757038 1.16300554773711E-05 NRP1, LGALS3, NTF3, CCL5 29 28 17535 86.3793103448275 6.12188940489211E-03 6.82067841513589E-04 1.68747106156219E-02 P_DIRECT GOTERM_B GO:0045666~positive regulation 5 0.130344108446298 2.06248618314800E-05 BDNF, CCL5, TIMP2, NGF, EPO 29 103 17535 29.3521928356210 1.08309575339391E-02 1.08841118542379E-03 2.99239697393538E-02 P_DIRECT of neuron differentiation GOTERM_B GO:0038163~thrombopoietin- 3 0.078206465067779 2.45158211382288E-05 LOC103690065, THPO 29 5 17535 362.7931034482750 1.28610923669397E-02 1.17608171266869E-03 3.55683065415890E-02 P_DIRECT mediated signaling pathway GOTERM_B GO:0045664~regulation of neuron 4 0.104275286757038 2.51316591110733E-05 NTF4, NTF3, TIMP2, NGF 29 36 17535 67.1839080459770 1.31820286580957E-02 1.10519571718481E-03 3.64616315116639E-02 P_DIRECT differentiation GOTERM_B GO:0060754~positive regulation 3 0.078206465067779 5.13815096763789E-05 VEGFB, PGF, CCL5 29 7 17535 259.1379310344820 2.67654177317949E-02 2.08475726156420E-03 7.45323458199442E-02 P_DIRECT of mast cell chemotaxis GOTERM_B GO:0042490~mechanoreceptor 3 0.078206465067779 5.13815096763789E-05 BDNF, NTF4, NTF3 29 7 17535 259.1379310344820 2.67654177317949E-02 2.08475726156420E-03 7.45323458199442E-02 P_DIRECT differentiation GOTERM_B GO:0051045~negative regulation 3 0.0782064650677789 0.0000513815096763789 TIMP4, TIMP2, TIMP1 29 7 17535 259.137931034482 0.0267654177317949 0.0020847572615642 0.0745323458199442 P_DIRECT of membrane protein ectodomain proteolysis GOTERM_B GO:0007411~axon guidance 5 0.130344108446298 7.66168817887790E-05 BDNF, NRP1, NTF3, GAS1, GFRA3 29 144 17535 20.9949712643678 3.96478735436459E-02 2.88549061649256E-03 1.11119012783411E-01 P_DIRECT GOTERM_B GO:0000186~activation of 4 0.104275286757038 9.04865892967610E-05 BDNF, NTF4, NTF3, NGF 29 55 17535 43.9749216300940 4.66556241693946E-02 3.18020446056810E-03 1.31222236227157E-01 P_DIRECT MAPKK activity GOTERM_B GO:0007265~Ras protein signal 4 0.104275286757038 1.06084172223918E-04 BDNF, NTF4, NTF3, NGF 29 58 17535 41.7003567181926 5.44754386899187E-02 3.49484215824258E-03 1.53825400498164E-01 P_DIRECT transduction GOTERM_B GO:0045654~positive regulation 3 0.078206465067779 1.34039536298651E-04 LOC103690065, THPO 29 11 17535 164.9059561128520 6.83309451986229E-02 4.15473444948166E-03 1.94324866983586E-01 P_DIRECT of megakaryocyte differentiation GOTERM_B GO:0043066~negative regulation 7 0.182481751824817 1.38291433609564E-04 VEGFB, BDNF, LGALS3, GAS1, TIMP1, 29 517 17535 8.1868205162409 7.04204820232909E-02 4.04861142282519E-03 2.00483331055645E-01 P_DIRECT of apoptotic process NGF, EPO GOTERM_B GO:0002544~chronic 3 0.078206465067779 1.89717053201166E-04 BDNF, CCL2, CCL5 29 13 17535 139.5358090185670 9.53255351387846E-02 5.25876127446056E-03 2.74940379088783E-01 P_DIRECT inflammatory response GOTERM_B GO:0007399~nervous system 5 0.130344108446298 2.66184597993192E-04 BDNF, NRP1, NTF3, GFRA1, GFRA2 29 199 17535 15.1923410154219 1.31132097826889E-01 7.00356872837393E-03 3.85558976810074E-01 P_DIRECT development GOTERM_B GO:0007169~transmembrane 4 0.104275286757038 0.000307566923539203 BDNF, NTF4, NTF3, GFRA2 29 83 17535 29.1400083090984 0.149916173091019 0.00770446794669976 0.445375345467968 P_DIRECT receptor protein tyrosine kinase signaling pathway GOTERM_B GO:0050930~induction of positive 3 0.078206465067779 3.29483883885430E-04 VEGFB, NTF3, PGF 29 17 17535 106.7038539553750 1.59699872848005E-01 7.87772302612188E-03 4.77041819230339E-01 P_DIRECT chemotaxis GOTERM_B GO:0051897~positive regulation 4 0.104275286757038 3.29922211425792E-04 VEGFB, LOC103690065, THPO 29 85 17535 28.4543610547667 1.59894390962230E-01 7.54649720458078E-03 4.77675036181823E-01 P_DIRECT of protein kinase B signaling GOTERM_B GO:0021675~nerve development 3 0.078206465067779 4.58946289411315E-04 BDNF, NRP1, NTF3 29 20 17535 90.6982758620689 2.15241510007929E-01 1.00483109908422E-02 6.63902887829315E-01 P_DIRECT GOTERM_B GO:0034097~response to cytokine 4 0.104275286757038 5.16152249983763E-04 TIMP4, CCL5, TIMP2, TIMP1 29 99 17535 24.4305120167189 2.38601759014033E-01 1.08447172353353E-02 7.46367667927982E-01 P_DIRECT GOTERM_B GO:0046579~positive regulation 3 0.078206465067779 5.56881016114261E-04 NOTCH2, NGF, EPO 29 22 17535 82.4529780564263 2.54809268298980E-01 1.12483769372428E-02 8.05041033673636E-01 P_DIRECT of Ras protein signal transduction GOTERM_B GO:0045766~positive regulation 4 0.104275286757038 8.39741276909425E-04 VEGFB, LGALS3, PGF, CCL5 29 117 17535 20.6719717064544 3.58258472925249E-01 1.62942940734908E-02 1.21163599231045E+00 P_DIRECT of angiogenesis GOTERM_B GO:0001666~response to hypoxia 5 0.130344108446298 8.41234767518076E-04 VEGFB, BDNF, CCL2, PGF, EPO 29 270 17535 11.1973180076628 3.58764752454563E-01 1.57446960068190E-02 1.21377867282322E+00 P_DIRECT GOTERM_B GO:0002548~monocyte 3 0.078206465067779 1.18398194379978E-03 CCL2, LGALS3, CCL5 29 32 17535 56.6864224137931 4.65013003181217E-01 2.13384520109803E-02 1.70436822481079E+00 P_DIRECT chemotaxis GOTERM_B GO:0034612~response to tumor 3 0.078206465067779 1.41610334280574E-03 BDNF, CCL2, CCL5 29 35 17535 51.8275862068965 5.26797790390877E-01 2.46326235346563E-02 2.03532470135092E+00 P_DIRECT necrosis factor GOTERM_B GO:0010951~negative regulation 4 0.104275286757038 1.65341152407704E-03 TIMP4, TIMP2, TIMP1, NGF 29 148 17535 16.3420316868592 5.82605639904897E-01 2.77911570458146E-02 2.37260366105767E+00 P_DIRECT of endopeptidase activity GOTERM_B GO:0043065~positive regulation 5 0.130344108446298 1.92634000895234E-03 NOTCH2, BDNF, NTF4, NTF3, NGF 29 338 17535 8.9446031422159 6.38715098869356E-01 3.13144828800940E-02 2.75917177392943E+00 P_DIRECT of apoptotic process GOTERM_B GO:0071222~cellular response to 4 0.104275286757038 2.33327584942380E-03 CCL2, CCL5, THPO 29 167 17535 14.4827586206896 7.08702195111810E-01 3.66861723540477E-02 3.33289822447293E+00 P_DIRECT lipopolysaccharide GOTERM_B GO:0051602~response to 3 0.078206465067779 2.98701901634178E-03 BDNF, NGF, EPO 29 51 17535 35.5679513184584 7.93923171193163E-01 4.53935001176607E-02 4.24799619895761E+00 P_DIRECT electrical stimulus GOTERM_B GO:0001934~positive regulation 4 0.104275286757038 3.11726840082769E-03 LOC103690065, NGF, THPO 29 185 17535 13.0736253494874 8.07659577506199E-01 4.60076913736676E-02 4.42935063078483E+00 P_DIRECT of protein phosphorylation GOTERM_B GO:0071403~cellular response to 2 0.0521376433785192 0.00319115390751856 CCL2, CCL5 29 2 17535 604.655172413793 0.815041431061108 0.0457966056464439 4.53208386390745 P_DIRECT high density lipoprotein particle stimulus GOTERM_B GO:0061193~taste bud 2 0.052137643378519 3.19115390751856E-03 BDNF, NTF4 29 2 17535 604.6551724137930 8.15041431061108E-01 4.57966056464439E-02 4.53208386390745E+00 P_DIRECT development GOTERM_B GO:1901215~negative regulation 3 0.078206465067779 3.59012619639801E-03 BDNF, CCL5, EPO 29 56 17535 32.3922413793103 8.50281362360757E-01 5.00294136767109E-02 5.08505577903920E+00 P_DIRECT of neuron death GOTERM_B GO:0030593~neutrophil 3 0.078206465067779 3.84597604283620E-03 CCL2, LGALS3, CCL5 29 58 17535 31.2752675386444 8.69265974084052E-01 5.21337294322847E-02 5.43809034990263E+00 P_DIRECT chemotaxis GOTERM_B GO:0048666~neuron development 3 0.078206465067779 4.66293425289669E-03 NRP1, NTF3, GFRA3 29 64 17535 28.3432112068965 9.15227775612800E-01 6.13162005348190E-02 6.55720288031619E+00 P_DIRECT GOTERM_B GO:0048812~neuron projection 3 0.078206465067779 5.24823450590771E-03 NTF4, NTF3, NGF 29 68 17535 26.6759634888438 9.37859974746762E-01 6.71017344464367E-02 7.35138230380103E+00 P_DIRECT morphogenesis GOTERM_B GO:0001938~positive regulation 3 0.078206465067779 5.55293050307255E-03 VEGFB, CCL2, PGF 29 70 17535 25.9137931034482 9.47140509951886E-01 6.91993931035688E-02 7.76232495899820E+00 P_DIRECT of endothelial cell proliferation GOTERM_B GO:0007264~small GTPase 4 0.104275286757038 6.00838132454098E-03 BDNF, NTF4, NTF3, NGF 29 234 17535 10.3359858532272 9.58497194778645E-01 7.29629699110510E-02 8.37342688358676E+00 P_DIRECT mediated signal transduction GOTERM_B GO:0035860~glial cell-derived 2 0.0521376433785192 0.00637248692724557 GFRA4, GFRA2 29 4 17535 302.327586206896 0.965796918236099 0.0754966399363654 8.85925247500442 P_DIRECT neurotrophic factor receptor signaling pathway GOTERM_B GO:0045185~maintenance of 2 0.052137643378519 6.37248692724557E-03 LGALS3, LGALS1 29 4 17535 302.3275862068960 9.65796918236099E-01 7.54966399363654E-02 8.85925247500442E+00 P_DIRECT protein location GOTERM_B GO:0007267~cell-cell signaling 3 0.078206465067779 8.08853489107273E-03 NTF4, CCL5, NGF 29 85 17535 21.3407707910750 9.86269177681539E-01 9.28587381544809E-02 1.11168533494755E+01 P_DIRECT GOTERM_B GO:0060548~negative regulation 3 0.078206465067779 8.64756561353670E-03 BDNF, NTF4, CCL5 29 88 17535 20.6132445141065 9.89804116556367E-01 9.68855841305045E-02 1.18409859961856E+01 P_DIRECT of cell death GOTERM_B GO:0014823~response to activity 3 0.078206465067779 9.41922976972766E-03 BDNF, CCL2, CCL5 29 92 17535 19.7170164917541 9.93241295342080E-01 1.02936639287905E-01 1.28315291154052E+01 P_DIRECT GOTERM_B GO:0009725~response to 3 0.078206465067779 1.08408604118529E-02 BDNF, TIMP4, TIMP2 29 99 17535 18.3228840125391 9.96833811482893E-01 1.15251303903753E-01 1.46293205921333E+01 P_DIRECT hormone GOTERM_B GO:2001200~positive regulation 2 0.052137643378519 1.11261359435861E-02 LGALS3, LGALS1 29 7 17535 172.7586206896550 9.97281092202592E-01 1.15801273616719E-01 1.49858947262786E+01 P_DIRECT of dendritic cell differentiation GOTERM_B GO:0050731~positive regulation 3 0.0782064650677789 0.01147746173627240 VEGFB, NRP1, NTF3 29 102 17535 17.783975659229 0.997746217794204 0.1169652497188650 15.42312151635150 P_DIRECT of peptidyl-tyrosine phosphorylation GOTERM_B GO:0038180~nerve growth factor 2 0.052137643378519 1.42830439103850E-02 SORT1, NGF 29 9 17535 134.3678160919540 9.99497453801174E-01 1.40939956110593E-01 1.88403098002536E+01 P_DIRECT signaling pathway GOTERM_B GO:0048672~positive regulation 2 0.052137643378519 1.42830439103850E-02 BDNF, NGF 29 9 17535 134.3678160919540 9.99497453801174E-01 1.40939956110593E-01 1.88403098002536E+01 P_DIRECT of collateral sprouting GOTERM_B GO:0048245~eosinophil 2 0.052137643378519 1.58578513259425E-02 LGALS3, CCL5 29 10 17535 120.9310344827580 9.99783959413941E-01 1.52522563862112E-01 2.07016385295774E+01 P_DIRECT chemotaxis GOTERM_B GO:0071407~cellular response to 3 0.078206465067779 1.61271203036516E-02 CCL2, LGALS1, CCL5 29 122 17535 14.8685698134539 9.99813023751022E-01 1.52180140324408E-01 2.10158910940860E+01 P_DIRECT organic cyclic compound GOTERM_B GO:0043434~response to peptide 3 0.078206465067779 1.79157654114438E-02 TIMP4, TIMP1, NGF 29 129 17535 14.0617481956696 9.99928462397055E-01 1.64813111795627E-01 2.30740917653948E+01 P_DIRECT hormone GOTERM_B GO:0071356~cellular response to 3 0.078206465067779 1.89741156543013E-02 BDNF, CCL2, CCL5 29 133 17535 13.6388384754990 9.99959515735906E-01 1.70811158585070E-01 2.42683081707258E+01 P_DIRECT tumor necrosis factor GOTERM_B GO:0051384~response to 3 0.078206465067779 1.89741156543013E-02 CCL2, CCL5, NGF 29 133 17535 13.6388384754990 9.99959515735906E-01 1.70811158585070E-01 2.42683081707258E+01 P_DIRECT glucocorticoid GOTERM_B GO:0048246~macrophage 2 0.052137643378519 1.90001910471487E-02 CCL2, LGALS3 29 12 17535 100.7758620689650 9.99960079935016E-01 1.68194746586171E-01 2.42975119287967E+01 P_DIRECT chemotaxis GOTERM_B GO:0010759~positive regulation 2 0.052137643378519 2.21328545937377E-02 CCL2, CCL5 29 14 17535 86.3793103448275 9.99992624977285E-01 1.90246344601454E-01 2.77307095062148E+01 P_DIRECT of macrophage chemotaxis GOTERM_B GO:0048485~sympathetic nervous 2 0.052137643378519 2.52558706603491E-02 NRP1, GFRA3 29 16 17535 75.5818965517241 9.99998637766062E-01 2.10972508970293E-01 3.10085733124405E+01 P_DIRECT system development GOTERM_B GO:0090280~positive regulation 2 0.052137643378519 2.83692678626112E-02 CCL2, LGALS3 29 18 17535 67.1839080459770 9.99999748431523E-01 2.30483014015037E-01 3.41381148146018E+01 P_DIRECT of calcium ion import GOTERM_B GO:0090026~positive regulation 2 0.052137643378519 2.83692678626112E-02 CCL2, CCL5 29 18 17535 67.1839080459770 9.99999748431523E-01 2.30483014015037E-01 3.41381148146018E+01 P_DIRECT of monocyte chemotaxis GOTERM_B GO:0009651~response to salt 2 0.052137643378519 3.30213906814639E-02 CCL5, EPO 29 21 17535 57.5862068965517 9.99999980042514E-01 2.59554123193691E-01 3.85688868182320E+01 P_DIRECT stress GOTERM_B GO:0048247~lymphocyte 2 0.052137643378519 3.45673197138337E-02 CCL2, CCL5 29 22 17535 54.9686520376175 9.99999991425402E-01 2.66240794472177E-01 3.99787122619179E+01 P_DIRECT chemotaxis GOTERM_B GO:0007422~peripheral nervous 2 0.052137643378519 3.61108653663010E-02 NTF3, NGF 29 23 17535 52.5787106446776 9.99999996316160E-01 2.72651353190517E-01 4.13562604430025E+01 P_DIRECT system development GOTERM_B GO:0035924~cellular response to 2 0.0521376433785192 0.036110865366301 NRP1, GAS1 29 23 17535 52.5787106446776 0.99999999631616 0.272651353190517 41.3562604430025 P_DIRECT vascular endothelial growth factor stimulus GOTERM_B GO:0045672~positive regulation 2 0.052137643378519 3.61108653663010E-02 NOTCH2, CCL5 29 23 17535 52.5787106446776 9.99999996316160E-01 2.72651353190517E-01 4.13562604430025E+01 P_DIRECT of osteoclast differentiation GOTERM_B GO:0002040~sprouting 2 0.052137643378519 4.07272374275235E-02 NRP1, PGF 29 26 17535 46.5119363395225 9.99999999707964E-01 2.98194597106070E-01 4.53025297359400E+01 P_DIRECT angiogenesis GOTERM_B GO:0031663~lipopolysaccharide- 2 0.052137643378519 4.83738525995331E-02 CCL2, CCL5 29 31 17535 39.0100111234705 9.99999999995731E-01 3.40024760079845E-01 5.12996945977381E+01 P_DIRECT mediated signaling pathway GOTERM_B GO:0008625~extrinsic apoptotic 2 0.0521376433785192 0.048373852599533 SORT1, NGF 29 31 17535 39.0100111234705 0.99999999999573 0.340024760079845 51.2996945977381 P_DIRECT signaling pathway via death domain receptors GOTERM_B GO:0045930~negative regulation 2 0.052137643378519 4.98961064887673E-02 GAS1, TIMP2 29 32 17535 37.7909482758620 9.99999999998167E-01 3.44441342662957E-01 5.24179834887691E+01 P_DIRECT of mitotic cell cycle GOTERM_B GO:0008283~cell proliferation 3 0.078206465067779 5.25970803191377E-02 LOC103690065, THPO 29 232 17535 7.8188168846611 9.99999999999592E-01 3.55252427439180E-01 5.43435536323627E+01 P_DIRECT GOTERM_B GO:0043523~regulation of neuron 2 0.052137643378519 5.44487928080359E-02 BDNF, NTF3 29 35 17535 34.5517241379310 9.99999999999854E-01 3.61030060027264E-01 5.56214755931297E+01 P_DIRECT apoptotic process GOTERM_B GO:2001240~negative regulation 2 0.0521376433785192 0.055961674741062 GFRAL, GAS1 29 36 17535 33.5919540229885 0.99999999999994 0.364810486636885 56.6407552840043 P_DIRECT of extrinsic apoptotic signaling pathway in absence of ligand GOTERM_B GO:0016358~dendrite 2 0.052137643378519 5.59616747410615E-02 BDNF, NRP1 29 36 17535 33.5919540229885 9.99999999999937E-01 3.64810486636885E-01 5.66407552840043E+01 P_DIRECT development GOTERM_B GO:0051781~positive regulation 2 0.052137643378519 5.74722223786564E-02 VEGFB, PGF 29 37 17535 32.6840633737185 9.99999999999973E-01 3.68458782491865E-01 5.76366805982553E+01 P_DIRECT of cell division GOTERM_B GO:0043491~protein kinase B 2 0.052137643378519 5.74722223786564E-02 CCL2, CCL5 29 37 17535 32.6840633737185 9.99999999999973E-01 3.68458782491865E-01 5.76366805982553E+01 P_DIRECT signaling GOTERM_B GO:0033189~response to vitamin 2 0.052137643378519 6.34911392805074E-02 BDNF, EPO 29 41 17535 29.4953742640874 9.99999999999999E-01 3.94653502713984E-01 6.13973335688751E+01 P_DIRECT A GOTERM_B GO:0045773~positive regulation 2 0.052137643378519 6.34911392805074E-02 BDNF, NGF 29 41 17535 29.4953742640874 9.99999999999999E-01 3.94653502713984E-01 6.13973335688751E+01 P_DIRECT of axon extension GOTERM_B GO:2001237~negative regulation 2 0.0521376433785192 0.064990067375656 NRP1, LGALS3 29 42 17535 28.7931034482758 1.00000000000000 0.397619437256539 62.2842549761468 P_DIRECT of extrinsic apoptotic signaling pathway GOTERM_B GO:0044344~cellular response to 2 0.052137643378519 6.49900673756562E-02 CCL2, CCL5 29 42 17535 28.7931034482758 9.99999999999999E-01 3.97619437256539E-01 6.22842549761468E+01 P_DIRECT fibroblast growth factor stimulus GOTERM_B GO:0055093~response to 2 0.052137643378519 6.64866819157161E-02 BDNF, EPO 29 43 17535 28.1234963913392 9.99999999999999E-01 4.00488308757951E-01 6.31508477899632E+01 P_DIRECT hyperoxia GOTERM_B GO:0008544~epidermis 2 0.052137643378519 6.79809863346061E-02 NTF4, NTF3 29 44 17535 27.4843260188087 9.99999999999999E-01 4.03264790739821E-01 6.39975768237461E+01 P_DIRECT development GOTERM_B GO:0048167~regulation of 2 0.052137643378519 7.24500731987453E-02 BDNF, NTF4 29 47 17535 25.7300073367571 1.00000000000000E+00 4.19563539457930E-01 6.64230718248589E+01 P_DIRECT synaptic plasticity GOTERM_B GO:0048678~response to axon 2 0.052137643378519 7.39351714333759E-02 LGALS1, EPO 29 48 17535 25.1939655172413 1.00000000000000E+00 4.21928163068621E-01 6.71947854451022E+01 P_DIRECT injury GOTERM_B GO:0006954~inflammatory 3 0.078206465067779 8.10261068112367E-02 CCL2, CCL5, NGF 29 297 17535 6.1076280041797 1.00000000000000E+00 4.48361785852507E-01 7.06571028263078E+01 P_DIRECT response GOTERM_B GO:0070098~chemokine- 2 0.052137643378519 8.71982787678646E-02 CCL2, CCL5 29 57 17535 21.2159709618874 1.00000000000000E+00 4.69456983433076E-01 7.33906567777806E+01 P_DIRECT mediated signaling pathway GOTERM_B GO:0045785~positive regulation 2 0.052137643378519 8.71982787678646E-02 CCL2, CCL5 29 57 17535 21.2159709618874 1.00000000000000E+00 4.69456983433076E-01 7.33906567777806E+01 P_DIRECT of cell adhesion GOTERM_B GO:0071346~cellular response to 2 0.052137643378519 9.30340218830694E-02 CCL2, CCL5 29 61 17535 19.8247597512719 1.00000000000000E+00 4.88087891032195E-01 7.57553880208457E+01 P_DIRECT interferon-gamma GOTERM_B GO:0008344~adult locomotory 2 0.052137643378519 9.88337800432995E-02 NTF4, NGF 29 65 17535 18.6047745358090 1.00000000000000E+00 5.05616503243407E-01 7.79104402726861E+01 P_DIRECT behavior