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Autumn 2010 (Pdf) The Genome Scientist UW Genome Sciences | www.gs.washington.edu | Volume 5 No 1 | Autumn 2010 Genome Sciences Welcomes Five New Faculty Members Dr. Elhanan Borenstein Dr. James Bruce Dr. Su-In Lee Dr. Judit Villen Dr. Alejandro Wolf-Yadlin The Genome Scientist is published by the Department of Genome Sciences at the University of Washington. For more information, please see our website, www.gs.washington.edu. NOTES FROM THE CHAIR What a time to be in Genome Sciences! The Along with our research, education continues to thrive at past two years have been an exciting, yet all levels. Our graduate program is exceptional. Incoming challenging time. students these past couple years have been simply outstand- ing; current students are publishing exciting papers; graduat- As you can see from the cover, we have ing students are securing excellent post-docs. Time to degree welcomed fi ve outstanding new faculty into is falling. In the undergraduate arena we are revamping our the Department – Elhanan Borestein, Jim basic genetics course. As part of this we have recruited Mi- Bob Waterston Bruce, Su-In Lee, Judit Villen, and Alejandro chelle Smith to join the faculty as a Lecturer. She comes from Wolf-Yadlin. They bring real strengths in a post-doctoral NSF sponsored teaching program at the Uni- computational biology and proteomics to what are already versity of Colorado and will help organize the revised genetics strong programs. The diversity of their backgrounds is strik- course. Celeste Berg and Bonnie Brewer have also created a ing, and they connect us with new areas intellectually, on “CSI-Seattle” course for a small group of incoming freshmen. campus and in the world. You can read more about them on In fact, the course staged a “murder” outside the building that pp. 6-7; suffi ce it to say here that we are excited by their arriv- the students solved using the latest and greatest DNA foren- als and expect great things from them in the coming years. sics. In addition, for the past two summers the Department has hosted a half-dozen or so undergraduates from across That we were able to add any new faculty in these tough the country for a ten-week research experience. The students economic times was itself exciting. In the fall of 2008, just as presented their posters to the Department over pizza and we were about to launch our search for new faculty, the Uni- their accomplishments were most impressive. Beyond these versity announced a hiring freeze, and as the recession took more traditional measures, the Department continues to off er hold in December, the University looked again at exceptions its summer public lecture series “Wednesday at the Genome” it had granted. Fortunately Genome Sciences was allowed to for the fourth year with 150-200 people attending each of go ahead, and we were rewarded with wonderful new hires. the 4 talks. In addition to all this, as you can read about on On the down side, the state has severely cut the University p. 12, Maureen Munn’s outreach program continues to bring budget with some devastating impacts on some departments. genome science into the high school classroom. We can only hope that the Governor and Legislature in future budgets recognize the critical role of the University in the The past couple years have also brought some changes to the future of the state. administration. In particular, Paula Kassos, who began with me in St. Louis in 1992, retired this past year. She married Dan On the science front, new technologies, particularly DNA James and has moved to North Carolina (but she still keeps in sequencing technologies, are revolutionizing our fi eld, open- touch through email). That left a big hole in the Department, ing whole new avenues of exploration. Fortuitously, the but we were fortunate to have Liz Lancaster as an interim NIH received almost $10B in ARRA (stimulus) funding in the director. In the middle of August, Nancy Cameron came on spring of 2009 just as the new technologies were building up board as director. Nancy comes to us from the Department steam. The result has been an explosion in the volume of new of Electrical Engineering and before that she worked in the genome sequences and in the ways in which DNA sequence central administration at the University of Oregon. Nancy can be used to assay biological function. The Department brings terrifi c administrative skills to us and we look forward was particularly well positioned to exploit this combination to working with her in the coming years to make this an ever of new technology and an infusion of funds. In conjunction better department. with the award of an NHLBI grant, the Northwest Genomics Center was created and is now in the process of sequencing This just scratches the surface of activities in Genome Sci- the protein-coding portions of thousands of patient genomes ences these past couple years. The combination of disciplines, by September, 2011. With the additional help of the Washing- ages and personalities has made Genome Sciences a hive of ton Research Foundation and the Washington’s Life Science activity. The faculty continue to receive recognition at all levels Discovery Fund, the Department now houses some 16 high (see pp. 4-5). Our impressive faculty interaction map, which throughput DNA sequencing instruments, producing the depicts the faculty as nodes and their shared projects, grants equivalent of a human genome sequence every hour – simply and papers as edges (courtesy of Bill Noble), grows ever more amazing! But beyond the sheer volume of data, the Depart- complex with collaborations bringing people together to ment has become a recognized leader in the creative appli- solve new problems. The Foege Building continues to be a joy, cation and analysis of these data sets (see pp. 8-10 for some with communal areas and the cafeteria facilitating interac- examples). Not only are we discovering new genes underlying tions and enough fl exible space to allow us to accommodate human disease, we are creating the knowledge base that will our new initiatives. Amazingly, in less than fi ve years we have enable us to understand eventually how yeast, worms, fl ies almost fi lled our half of the building! Please come by for a visit and mice work. With all the other wonderful science going on to see fi rst hand the remarkable energy and excitement. around here, the Department is pulsing with excitement! THE GENOME SCIENTIST 2 The Genome Scientist layout - Brian Giebel questions / comments - [email protected] NEWS & HONORS UW LAUNCHES NORTHWEST GENOMICS CENTER The National Heart, Lung, and Blood Institute (NHLBI) an- environment, and lifestyle choices, helping us bring the best nounced Oct. 1, 2009 that the University of Washington (UW) science to the patients who need it most,” said NHLBI Director will receive two of the six “Grand Opportunity”NHLBI Large- Dr. Elizabeth G. Nabel. Scale DNA Sequencing Project awards. The multi-institutional genomics project will examine the genetic connections to The Northwest Genomics Center in Seattle will be among the heart, lung, and blood diseases that account for three of the fi rst new, large-scale genomics centers focused entirely on leading causes of death in the United States. medical sequencing to be created in the United States in more than a decade. The UW also received $2 million in funding The research is co-funded by the National Institutes of Health from the state’s Life Sciences Discovery fund to support the (NIH) Director’s Offi ce. The two-year national project, at a total Center’s infrastructure. funding of $64 million, was made possible by the American Recovery and Reinvestment Act of 2009. “The Northwest Genomics Center will apply cutting edge, next generation sequencing technology to uncover the diff erences The UW will receive $25 million to launch the Northwest Ge- in our genetic code and explore how these may infl uence nomics Center, one of two sequencing centers for the project. traits, such as cholesterol and blood pressure, that impact The second sequencing center will be located at the Broad our risk for developing cardiovascular disease,”said Dr. Deb- Institute of MIT and Harvard in Cambridge, Mass. bie Nickerson, UW professor of genome sciences and one of the principal investigators for the new Center. Other principal The UW will also receive a $5.2 million grant, under the direc- investigators are Drs. Jay Shendure, Philip Green, and Mark tion of Dr. Michael Bamshad, UW professor of pediatrics in Rieder, who are also faculty members in the UW Department the Division of Genetic Medicine, to manage the lung disease of Genome Sciences. population research portion of the national project. Ohio State University, Washington University in St. Louis, and the Univer- “This is an extraordinary team eff ort to which we all bring sity of Virginia are the other participating institutions manag- individual expertise,”Nickerson said. She and Rieder are lead- ing cardiovascular and blood disease projects. ers in medical sequencing of cardiovascular, blood and lung diseases. Shendure is one of the pioneers in the development “This extraordinary collaboration promises to deepen our and application of next generation sequencing technology, understanding of the complex interactions of genetics, the and Green is a world leader in developing new software tools for sequence analysis, including the tools that helped to gen- erate the human genome sequence. Bamshad, who will head the lung disease component of the national project, is noted for his work on common genetic variations in the United States population and how these af- fect individual and ethnic group diff erences in susceptibility to disease.
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