Ultra B-Complex W/PQQ BPQ26-LBL

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Specific to this order Color Label Version # V1 VEEVA Version # V1 Product information PANTONE Reflex Blue C Label Size: 2.125” x 7” (Pure size 3) Bottle Size: 190 cc BPQ26-LBL Fonts: Stag Sans & Univers BOS-LM-1996 Ultra B-Complex w/PQQ Stock: White paper 60 capsules Date: 7-31-2020 Laminate: Glossy Unwind#: #4 QE-022990 STORE IN A COOL, DRY PLACE. v1 * * Recommendations: As a dietary supplement, * %DV 167% 675% take 1 capsule, 1-2 times daily, with meals. 977% BPQ26 1,333% 5,688% 2,000% 10,417% Warning: If you are pregnant or lactating, 41,667% have any health condition or are taking any medication, consult your health professional code: before use. 10 mg 10 20 mg 108 mg 108 100 mg 100 mg 100 125 mg 125 Keep out of the reach of children. mg 12.7 400 mcg 96.7 mg Metafolin® is a registered trademark of Merck 1,000 mcg KGaA, Darmstadt, Germany. Ultra B-Complex 667 mcg DFE Amount Per Serving Use only if safety (400 mcg L-5-MTHF) seal is intact. )) w/PQQ 6 Contents may not fill )) ® 2 With Metafolin L-5-MTHF; package in order to ) accommodate required Enhanced B-complex support for 5 ‡ is a trademark of MGC (Japan) labeling. Please rely on mitochondrial and nerve health ® stated quantity. and 60% and , L-5-MTHF) , 2 Pure Encapsulations Certified Gluten-Free ® Gluten-free, Non-GMO Scan to learn about by the Gluten-Free & Hypoallergenic BioPQQ our hypoallergenic Certification Organization, (as methylcobalamin and (as methylcobalamin supplements www.gluten.org HCl and (as pyridoxine 6 pyrroloquinoline quinone pyrroloquinoline 12 ® Dietary Supplement Daily value (DV) not established (DV) Daily value * This statement has not been evaluated by the Food and Supplement Facts Serving 1 capsule size Servings per container 60 (as thiamin HCl) Thiamin (vitamin Riboflavin B B 5’ phosphate (activated riboflavin Niacin (as niacinamide and 8% (no-flush niacin)) inositol hexaniacinate Vitamin B B 5’ phosphate (activated 7% pyridoxal (as Metafolin Folate Vitamin B 50% adenosylcobalamin) Biotin acid Panthothenic (as calcium pantothenate) (B Alpha lipoic acid (thioctic acid) Luteolin BioPQQ disodium salt palmitate ascorbyl Other ingredients: vegetarian capsule (cellulose, water), ‡ Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. 60 CAPSULES manufactured by: 490 Boston Post Road, Sudbury, MA 1-800-753-2277 www.PureEncapsulations.com.

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Effect of Pyrroloquinoline Quinone Disodium in Female Rats During
Downloaded from British Journal of Nutrition (2019), 121, 818–830 doi:10.1017/S0007114519000047 © The Authors 2019 https://www.cambridge.org/core Effect of pyrroloquinoline quinone disodium in female rats during gestating and lactating on reproductive performance and the intestinal barrier functions in the progeny . IP address: Boru Zhang, Wei Yang, Hongyun Zhang, Shiqi He, Qingwei Meng, Zhihui Chen and Anshan Shan* Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, People’s Republic of China 170.106.202.226 (Submitted 26 September 2018 – Final revision received 21 December 2018 – Accepted 28 December 2018 – First published online 28 January 2019) , on Abstract 30 Sep 2021 at 19:42:41 The objective of this study was to investigate the effects of dietary pyrroloquinoline quinone disodium (PQQ·Na2) supplementation on the reproductive performance and intestinal barrier functions of gestating and lactating female Sprague–Dawley (SD) rats and their offspring. Dietary supplementation with PQQ·Na2 increased the number of implanted embryos per litter during gestation and lactation at GD 20 and increased the number of viable fetuses per litter, and the weight of uterine horns with fetuses increased at 1 d of newborn. The mRNA expression levels of catalase (CAT), glutathione peroxidase (GPx2), superoxide dismutase (SOD1), solute carrier family 2 member 1 (Slc2a1) · and solute carrier family 2 member 3 (Slc2a3) in the placenta were increased with dietary PQQ Na2 supplementation. Dietary , subject to the Cambridge Core terms of use, available at supplementation with PQQ·Na2 in gestating and lactating rats increased the CAT, SOD and GPx activities of the jejunal mucosa of weaned rats on PD 21.
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Annotation Guidelines for Experimental Procedures
Annotation Guidelines for Experimental Procedures Developed By Mohammed Alliheedi Robert Mercer Version 1 April 14th, 2018 1- Introduction and background information What is rhetorical move? A rhetorical move can be defined as a text fragment that conveys a distinct communicative goal, in other words, a sentence that implies an author’s specific purpose to readers. What are the types of rhetorical moves? There are several types of rhetorical moves. However, we are interested in 4 rhetorical moves that are common in the method section of a scientific article that follows the Introduction Methods Results and Discussion (IMRaD) structure. 1- Description of a method: It is concerned with a sentence(s) that describes experimental events (e.g., “Beads with bound proteins were washed six times (for 10 min under rotation at 4°C) with pulldown buffer and proteins harvested in SDS-sample buffer, separated by SDS-PAGE, and analyzed by autoradiography.” (Ester & Uetz, 2008)). 2- Appeal to authority: It is concerned with a sentence(s) that discusses the use of standard methods, protocols, and procedures. There are two types of this move: - A reference to a well-established “standard” method (e.g., the use of a method like “PCR” or “electrophoresis”). - A reference to a method that was previously described in the literature (e.g., “Protein was determined using fluorescamine assay [41].” (Larsen, Frandesn and Treiman, 2001)). 3- Source of materials: It is concerned with a sentence(s) that lists the source of biological materials that are used in the experiment (e.g., “All microalgal strains used in this study are available at the Elizabeth Aidar Microalgae Culture Collection, Department of Marine Biology, Federal Fluminense University, Brazil.” (Larsen, Frandesn and Treiman, 2001)).
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Mechanism of Reconstitution/Activation of the Soluble PQQ-Dependent Glucose Dehydrogenase from Acinetobacter Calcoaceticus
Mechanism of reconstitution/activation of the soluble PQQ-dependent glucose dehydrogenase from Acinetobacter calcoaceticus: a comprehensive study Claire Stines-Chaumeil, François Mavré, Brice Kauffmann, Nicolas Mano, Benoit Limoges To cite this version: Claire Stines-Chaumeil, François Mavré, Brice Kauffmann, Nicolas Mano, Benoit Limoges. Mecha- nism of reconstitution/activation of the soluble PQQ-dependent glucose dehydrogenase from Acine- tobacter calcoaceticus: a comprehensive study. ACS Omega, ACS Publications, 2020, 10.1021/ac- somega.9b04034. hal-02457126 HAL Id: hal-02457126 https://hal.archives-ouvertes.fr/hal-02457126 Submitted on 27 Jan 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Mechanism of reconstitution/activation of the soluble PQQ-dependent glucose dehydrogenase from Acinetobacter calcoaceticus: a comprehensive study Claire Stines-Chaumeil,*,a Francois Mavré,b Brice Kauffmann,c Nicolas Mano,a and Benoit Limoges*,b a CNRS, Université de Bordeaux, CRPP, UMR5031, 115 Avenue Schweitzer, F-33600 Pessac, France. b Université de Paris, Laboratoire d'Electrochimie Moléculaire, UMR 7591, CNRS, F-75013 Paris, France. c CNRS UMS3033, INSERM US001, Université de Bordeaux, IECB, 2, Rue Robert Escarpit, F- 33607 Pessac, France. KEYWORDS: pyrroloquinoline quinone, enzyme reconstitution, enzyme cofactor, apoenzyme, glucose dehydrogenase.
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Prolonging Healthy Aging: Longevity Vitamins and Proteins PERSPECTIVE Bruce N
PERSPECTIVE Prolonging healthy aging: Longevity vitamins and proteins PERSPECTIVE Bruce N. Amesa,1 Edited by Cynthia Kenyon, Calico Labs, San Francisco, CA, and approved September 13, 2018 (received for review May 30, 2018) It is proposed that proteins/enzymes be classified into two classes according to their essentiality for immediate survival/reproduction and their function in long-term health: that is, survival proteins versus longevity proteins. As proposed by the triage theory, a modest deficiency of one of the nutrients/cofactors triggers a built-in rationing mechanism that favors the proteins needed for immediate survival and reproduction (survival proteins) while sacrificing those needed to protect against future damage (longevity proteins). Impairment of the function of longevity proteins results in an insidious acceleration of the risk of diseases associated with aging. I also propose that nutrients required for the function of longevity proteins constitute a class of vitamins that are here named “longevity vitamins.” I suggest that many such nutrients play a dual role for both survival and longevity. The evidence for classifying taurine as a conditional vitamin, and the following 10 compounds as putative longevity vitamins, is reviewed: the fungal antioxidant ergo- thioneine; the bacterial metabolites pyrroloquinoline quinone (PQQ) and queuine; and the plant antioxidant carotenoids lutein, zeaxanthin, lycopene, α-andβ-carotene, β-cryptoxanthin, and the marine carotenoid astaxanthin. Because nutrient deficiencies are highly prevalent in the United States (and elsewhere), appro- priate supplementation and/or an improved diet could reduce much of the consequent risk of chronic disease and premature aging. vitamins | essential minerals | aging | nutrition I propose that an optimal level of many of the known adverse health effects.
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PQQ —— a Novel Human Essential Nutrient General Information of PQQ
PQQ —— A Novel Human Essential Nutrient General Information of PQQ Stable small molecular Chemical Name: Pyrroloquinoline Quinone Disodium Salt (PQQ●Na2) Molecular Formula: C14H4N2Na2O8 Molecular Weight: 374.17 CAS Number: 122628-50-6 Appearance: Reddish brown powder Melting Point: >300℃ (decomposed during the assay) Solubility: Water-soluble (3g/L at 25℃) Stability: Stable for at least 24 months. 50+ Years of Research 1964 1979 1989 2003 2008 2010 2012 2016 Discovered Extracted Identified Kasahara MGC’s UC Davis ZCHT ZCHT as the third from as an and Kato NDI filing published completed PQQ redox methanol essential stated that accepted PQQ developme obtained cofactor after dehydrogen nutrients PQQ was a by FDA promotes nt via US FDA nicotinamide ase and in animal. new mitochondrial chemical GRAS and flavin in identified vitamin in biogenesis synthesis bacteria its Nature LE introduced molecular Magazine the 1st PQQ structure Supplement More than 800 studies on PQQ published (by July 2016) 55 41 39 37 33 32 32 30 30 27 26 25 25 24 24 23 22 22 21 21 20 20 19 19 19 19 19 18 17 16 11 6 4 4 2 3 2 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 The Discovery of PQQ Produced by Bacteria Plants Growth Factor PQQ is Widely Distributed in Nature Playing important roles in Mammals Nature 1979；280(5725), 843-844 PQQ is Widely Distributed in Daily Life The PQQ Food PQQ(ng/g) Food PQQ(ng/g or ml) content of food products
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Why Are You So
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Protective Effects of Pyrroloquinoline Quinone Against Oxidative Stress
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GRAS Notice 709, Pyrroloquinoline Quinone Disodium Salt
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Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes
www.symbiosisonline.org Symbiosis www.symbiosisonlinepublishing.com Research article SOJ Pharmacy & Pharmaceutical Sciences Open Access Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes Associated Testicular Dysfunction and Oxidative Damages in Testis of Streptozotocin-Induced Diabetic Mice: Histopathological Study Narendra Kumar* and Anand Kar School of life Sciences, Devi Ahilya University, Takshashila Campus, Indore, India Received: October 02, 2017; Accepted: November 03, 2017; Published: November 10, 2017 *Corresponding author: Narendra Kumar, School of Life Sciences, Devi Ahilya University, Takshashila Campus, Indore, Madhya Pradesh, India, Tel: +91 9425481242; Fax +91 731 2360026; E-mail: [email protected] fertility through hyperglycemia-induced testicular dysfunctions Abstract leading to atrophy of sex organs; decrease in testosterone level; The aim of this study was to investigate the hitherto unknown loss in libido and in sperm count and motility [4, 5]. Agbaje, et potential of Pyrroloquinoline Quinone (PQQ) in regulating diabetes al. [6] also reported that streptozotocin (STZ)-induced diabetic associated testicular dysfunctions and oxidative damages in testis of adult mice. Seven groups such as normoglycemic and PQQ treated DNA in sperms. These adverse effects are thought to be due to controls; STZ-treated and STZ + PQQ treated (5, 10 and 20 mg/ animals show a significant increase in the level of fragmented kg/day, separately) and STZ + Vit.C (50 mg/kg) were established. DM associated oxidative stress [7-9]. These observations led us to After 18 days of experimentation, alterations in the markers of assume that a potent antioxidant is crucial in reducing the damage caused by oxidative stress. Some experimental, epidemiological testosterone and testicular histology were evaluated.
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GALLEY ARS PQQ Final Report.Pdf
Does pyrroloqinoline quinone have potential as a novel therapy to prevent oxidative stress and mitochondrial dysfunction under conditions of sepsis? Helen F. Galley, Damon A. Lowes and Nigel R. Webster. Division of Applied Medicine School of Medicine and Dentistry University of Aberdeen. Funded by the Anaesthetic Research Society Heath Family Project Grant Background Around 37,000 people die from sepsis each year in the UK. Despite the the Surviving Sepsis Campaign, the mortality rate remains at 31% for sepsis overall and 70% in patients who go on to develop multiple organ failure. Sepsis is essentially a dysregulated massive inflammatory response with release of cytokines, oxidative stress and mitochondrial dysfunction. Reactive oxygen species (ROS) are generated as by-products of the four electron reduction of molecular oxygen to water during the production of ATP. ROS can be damaging so their activity is normally tightly regulated by a collaborative network of antioxidants. When antioxidant defences are overwhelmed, oxidative stress results, which can cause damage to lipids, proteins, and nucleic acids, both within mitochondria and cells. Oxidative stress, inflammation and mitochondrial dysfunction are the hallmarks of sepsis [1] and the potential for benefit from antioxidants acting specifically in mitochondria has been recognised in several recent reviews [2,3,4]. We have shown that antioxidants which act within mitochondria are more effective at reducing oxidative damage caused by sepsis than antioxidants which do not specifically protect mitochondria [5,6,7]. Melatonin, for example, is highly lipophilic and can reach all cellular compartments with the highest levels in mitochondria. We have shown that melatonin and its metabolites reduce cytokine levels, oxidative stress and mitochondrial dysfunction in cells treated with lipopolysaccharide (LPS) and peptidoglycan G (PepG) to mimic conditions similar to those seen in sepsis [6].
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Characterisation, Classification and Conformational Variability Of
Characterisation, Classification and Conformational Variability of Organic Enzyme Cofactors Julia D. Fischer European Bioinformatics Institute Clare Hall College University of Cambridge A thesis submitted for the degree of Doctor of Philosophy 11 April 2011 This dissertation is the result of my own work and includes nothing which is the outcome of work done in collaboration except where specifically indicated in the text. This dissertation does not exceed the word limit of 60,000 words. Acknowledgements I would like to thank all the members of the Thornton research group for their constant interest in my work, their continuous willingness to answer my academic questions, and for their company during my time at the EBI. This includes Saumya Kumar, Sergio Martinez Cuesta, Matthias Ziehm, Dr. Daniela Wieser, Dr. Xun Li, Dr. Irene Pa- patheodorou, Dr. Pedro Ballester, Dr. Abdullah Kahraman, Dr. Rafael Najmanovich, Dr. Tjaart de Beer, Dr. Syed Asad Rahman, Dr. Nicholas Furnham, Dr. Roman Laskowski and Dr. Gemma Holli- day. Special thanks to Asad for allowing me to use early development versions of his SMSD software and for help and advice with the KEGG API installation, to Roman for knowing where to find all kinds of data, to Dani for help with R scripts, to Nick for letting me use his E.C. tree program, to Tjaart for python advice and especially to Gemma for her constant advice and feedback on my work in all aspects, in particular the chemistry side. Most importantly, I would like to thank Prof. Janet Thornton for giving me the chance to work on this project, for all the time she spent in meetings with me and reading my work, for sharing her seemingly limitless knowledge and enthusiasm about the fascinating world of enzymes, and for being such an experienced and motivational advisor.
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NQO1: a Target for the Treatment of Cancer and Neurological Diseases, and a Model to Understand Loss of Function Disease Mechanisms
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