Comparative toxicological effects of orally and intraperitoneally administered aqueous extracts of Abrus precatorius leaf in Mus musculus Saganuwanalhaji Saganuwan*1, PatriCk azubuike Onyeyili1, atikatu Oyiza Suleiman2 1Department of Veterinary Physiology, Pharmacology and biochemistry College of Veterinary medicine university of agriculture, P.m.b. 2373 makurdi, benue State, nigeria 2Department of animal health and Production Faculty of Veterinary medicine university of abuja, nigeria *corresponding author: phone: +2347039309400, +2348027444269, e-mail: pharn_
[email protected] S u m m a r y Phytochemical analysis revealed the presence of alkaloids, flavonoids, saponins, tannins, re- ducing sugar, total glycoside and saponin glycosides in high concentration. Proximate analy- sis revealed the presence of moisture (6.18%), dry matter (93.90%), crude protein (12.06%), crude fibre (15.33%), nitrogen free extract (34.12%), ash (12.28%) and oil (19.21%). Compara- tive toxicological assessment of orally and intraperitoneally administered aqueous extracts of Abrus precatorius leaf was carried out in Swiss albino mice. median lethal doses (lD50) of orally and intraperitoneally administered aqueous extracts of Abrus precatorius leaf were estimated at dose levels of 2558.9 mg/kg and 638 mg/kg body weight, respectively. intra- peritoneal 10 mg/kg body weight of the extract caused increased packed cell volume, neu- tropenia and decreased aspartate aminotransferase. however, 50 mg/kg oral dose caused increased packed cell volume, neutropenia, decreased alkaline phosphatase and hypochlor- aemia, whereas oral aqueous dose of 250 mg/kg of body weight caused body weight gain, neutropenia, decreased asparatate aminotransferase and alanineaminotransferase. all the test doses caused lymphocytosis and hypercreatinaemia, hence aqueous extract of Abrus precatorius leaf is toxic at dose levels of 10, 50 and 250 mg/kg body weight.