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Screening for Diabetic Retinopathy

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Screening for Diabetic Retinopathy Screening for diabetic retinopathy All patients with diabetes are at risk of developing diabetic retinopathy. J Rice, FCOphth (SA) Ophthalmologist, Division of Ophthalmology, Faculty of Health Sciences, University of Cape Town, South Africa Correspondence to: J Rice ([email protected]) Good glucose control[1,2] and the treatment retinopathy. Unfortunately fundus cameras of the visual acuity test is that maculopathy of hypertension[3] and hyperlipidaemia are expensive and not yet widely available. can be dicult to diagnose in some patients. remain the key strategies in preventing While such screening programmes are being Unexplained visual acuity of 6/12 or worse diabetic retinopathy and its progression. developed in the private and public sectors may indicate maculopathy even if not obvious Unfortunately, some degree of retinopathy in South Africa, screening with a direct on examination and should be referred. will eventually develop in almost all type 1 ophthalmoscope still has an important place diabetics and over 60% of type 2 diabetics in the detection of diabetic retinopathy. is Step 2: Dilate the pupils over a 20-year period.[4] article aims to review important clinical Is it always safe to dilate the pupils? features of diabetic retinopathy and provide Short-acting dilating drops are extremely Diabetic retinopathy is usually asymptomatic some practical tools for improved screening unlikely to cause ocular complications.[7] We in its early stages. Patients presenting with with the direct ophthalmoscope. would recommend Mydriacyl® (tropicamide) symptoms oen have more advanced disease which lasts up 6 hours. One drop is instilled and are more dicult to manage. ey are at When to start screening 3 or 4 times in each eye at 5-minute intervals. higher risk of permanent visual loss. Screening • Screening in children and adolescents: e risk of precipitating acute glaucoma is is a cost-eective tool in the ght against annual screening to start 3 - 5 years aer extremely low, even in patients in whom the diabetic blindness. It involves assessment of diagnosis, and once the patient is 10 anterior chamber may look shallow. Patients visual acuity (including the use of a pinhole years old.[5] with chronic glaucoma are also unlikely to to overcome refractive error) and a retinal • Type 1 diabetics generally do not develop experience adverse events from dilation. examination (fundoscopy) through a dilated retinopathy within 5 years of the diagnosis. We consider it better to advise the patient pupil. • Type 2 diabetics may have retinopathy about seeking care in the unlikely event before diabetes is diagnosed. ey should of a complication rather than omitting to With the rising prevalence of diabetes be screened at the time of diagnosis. screen. An informed patient in this setting there is an increasing need for eective is better o than a predisposed patient who retinal screening. Fundus photography has How often to screen spontaneously develops acute glaucoma one established itself in many countries as the • Annual screening is recommended. evening as the pupil dilates physiologically. preferred tool for screening for diabetic • Pregnant diabetics should preferably be Flexocam CME islandad.pdf 1 2013/04/11screened 5:30 before PM pregnancy, early in the Step 3: Examine the ‘red reflex’ rst trimester, in each trimester as well as is is done by examining the red reection 6 weeks postpartum.[6] of light emerging from the eye with the ophthalmoscope held about 50 cm from the Screening steps patient. Both eyes should be examined and Step 1: Visual acuity compared. Visual acuity should be performed with the patient’s current spectacles. A pinhole test is Interpretation of abnormal red reex: C used if vision is below normal (6/6). If the • Discrete small black areas: media vision improves with the pinhole this suggests opacities – most likely early cataract, M a residual refractive error. e importance sometimes corneal in origin. Y • Diusely dull or no reex: severe CM Advice to patients at the time of media opacity or disrupted anatomy – MY dilating: possible vitreous haemorrhage or retinal • Complications are extremely unlikely. detachment. ese will be accompanied CY • Symptoms of a possible complication: by severe visual loss. Visualisation of the CMY painful, red eye with worsening fundus may not be possible. K rather than improving vision. • Supply a contact number and course Step 4: Fundus examination of action in the event of a suspected Pearls for the use of the direct complication. ophthalmoscope: • Patients should not drive or engage • Examine the patient’s right eye with your in hazardous activities until vision right eye, and le eye with your le eye. clears as the pupils return to normal. e index nger should be on the focus wheel at all times. If you are examining 123 CME April 2013 Vol. 31 No. 4 Diabetic retinopathy the patient with your glasses on (distance keyhole into a room. You must get close the patient more comfortable and co- correction) then start on zero with the enough. Your free hand can be placed on operative. ophthalmoscope. If you remove your the patient’s forehead to help you judge • Ask the patient to look directly at the glasses, start with your refractive error your distance from the eye and your light to bring the macula (fovea) into (for example -2.00 is usually a red 2 on thumb can gently li the eyelid. view. Use the ‘red-free’ (green) lter on the dial). Actively seek a good focus on • If the pupil is widely dilated then use the ophthalmoscope to help identify the patient’s retina by rotating the focus the largest light. If the pupil fails to small haemorrhages, particularly at the wheel during examination. dilate well then the largest light creates fovea. • Make sure that you are holding the more scatter and a smaller one may ophthalmoscope close enough to your improve visualisation. Dimming the own eye and close enough to the patient’s ophthalmoscope light slightly may make eye. ink of trying to look through a How big is a ‘blot’ haemorrhage? It is useful to compare the size of the haemorrhage with the diameter of the large veins that emerge from the optic disc. If a haemorrhage is at least as large as the vein diameter at the disc it is a ‘blot’ rather than a smaller ‘dot’ haemorrhage. ‘Dot’ haemorrhages and microaneurysms may be indistinguishable. Fig. 3a. Maculopathy. Fig. 1. Normal fundus. Tips for examining the macula (Fig. 3): • Dim the ophthalmoscope light slightly • Start at the optic disc move temporally into the macula • To assess the fovea, ask the patient to look directly at the ophthalmoscope light • To identify small haemorrhages it can be helpful to use the ‘red free’ lter on the ophthalmoscope. is gives the light a green appearance and any haemorrhage will appear black. It will not improve visualising exudates which are best seen with the white light. Fig. 3b. Maculopathy within 1 disc diameter Fig. 2. Systematic examination. of the fovea. Table 1. Systematic examination and possible ndings Structure examined Possible features of diabetic retinopathy Optic disc New vessels (new vessels at the disc – NVD) (Fig. 7) All new vessels (NVD and new vessels elsewhere – NVE) have an appearance very dierent from the typical branching, tapering vessels of the normal retina. ey are ‘out of place’, oen forming looped random networks Major vessels in 4 quadrants Venous tortuosity/irregularity New vessels (NVE) Peripheral areas between vessels Microaneurysms Haemorrhages: ‘dot’ and ‘blot’ (Fig. 6) Larger ‘blot’ haemorrhages are a feature of more severe retinopathy, particularly if they occur in all four quadrants of the retina Exudates (yellow, discrete deposits or large clumps) Cotton wool spots (pale with blurred edges – Fig. 5) New vessels (NVE) Macula Exudates Haemorrhages Cotton wool spots: Any pathology in the macula is signicant and should be referred. Pathology within 1 disc diameter of the centre of the fovea is particularly signicant (Fig. 3b) 124 CME April 2013 Vol. 31 No. 4 Grading retinopathy 5/"2#*(464 7%*$*6(%,+8#42%+(464 7/$4"#.4*6(%,+8#42%+(464 94:4"4*6(%,+8#42%+(464 !"#$%&' 7%*$(5;<= 7/$4"#.4(5;<= 94:4"4(5;<= ;"/*%>4"#.%:4(<= )*%&%+#*(,%'&, 5/("4.%&/3#.86 7%+"/#&4@"6,2, A#"'4"(BC*/.D(8#42/""8#'4, </.(8#42/""8#'4, E4&/@,(C4#$%&' ?++#,%/&#*(2%+"/#&4@"6,2, H#"$(41@$#.4, 125 CME </.(8#42/""8#'4, )/../&(G//*(,3/., 9+#..4"4$(8#"$(41@$#.4, ;AI9 ;AI9 Diabetic retinopathy A#"'4"(BC*/.D(8#42/""8#'4, 54G(:4,,4*,(#.(.84($%,+(B5E<D ?????????????? E4&/@,(C4#$%&'(F%""4'@*#"%.6 April 2013 Vol. 31 No. 4 31No. Vol. April 2013 54G(:4,,4*,(4*,4G84"4(B5E0D 01#23*4, !"#$ &$%'"()%*+,-" !"#$ .$%'/)01230%%*+,-$%4(/3% !"#$ =$%>0?010%*+,-$%4(/3% Fig. 7. Proliferative DR. New Fig. 4 Mild NPDR. Fig. 5. Moderate NPDR. Blot Fig. 6. Severe NPDR. Blot Fig.vessels 7. Proliferative (NVD and DR.NVE) New. 5206/1152#07haemorrhages and28)%629:(/;235< maculopathy. " haemorrhages5206/1152#07 and28)%629:(/;235< maculopathy. " vessels (NVD and NVE). -+.%/& =4:%4G(%&(J(64#" =4>4" NPDR = non-proliferative diabetic retinopathy; DR = diabetic retinopathy. Diabetic?????????????????? retinopathy • Be proactive about the retinal Treatment by the References examination. Ask the patient to look in ophthalmologist 1. The Diabetes Control and Complications Trial. dierent directions. When the patient Laser treatment has been the cornerstone The effect of intensive diabetes treatment looks up, drop your head and look of treatment for diabetic retinopathy. is on the progression of diabetic retinopathy in upwards to view the superior peripheral remains the case for proliferative retinopathy. insulin-dependent diabetes mellitus. Arch retina etc. Anti-vascular endothelial growth factor (anti- Ophthalmol 1995;113:36-51. [http://dx.doi. Fig. 1 shows a normal fundus.
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