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Additional File 3 Sustaining Proliferative Signaling Evading Growth Suppressors -log10 -log10 pval pval ERK Cascade ( B Cell Receptor Signaling Cyclin E Associated Events During G1/S T 15 ERK Cascade ( CD4 T Cell Receptor Signal Inhibition Of Replication Initiation Of 15 Intracellular Signalling Through Adenosi ARMS Mediated Activation Cyclin A:Cdk2 Associated Events At S Pha Heterotrimeric GPCR Signaling Pathway (t Negative Regulation Of The PI3K/AKT Netw CREB Phosphorylation Through The Activat 10 APC Truncation Mutants Have Impaired AXI 10 Frs2 Mediated Activation Tetrachlorodibenzodioxin Inhibits The Re ERK Cascade ( FGF8 Signaling (Mouse) )// Spry Regulation Of FGF Signaling Negative Regulation Of (transcription By PTK6 Regulates RHO GTPases, RAS GTPase A Gene Expression Of Smad6/7 By R Smad:sma 5 5 Regulation Of RAS By GAPs SMAD2/SMAD3:SMAD4 Heterotrimer Regulates FCERI Mediated MAPK Activation Downregulation Of SMAD2/3:SMAD4 Transcri MAP2K And MAPK Activation MTOR Signaling Pathway TGF Beta Receptor Signaling Activates SM EGF Signaling Pathway ( EGF Signaling Pa 0 Cyclin D Associated Events In G1 0 GRB2 Events In EGFR Signaling// SHC1 Eve P53 Dependent G1 DNA Damage Response Signalling To P38 Via RIT And RIN TGF Beta Receptor Signaling In EMT (epit P38MAPK Events Activation Of RAS In B Cells AUF1 (hnRNP D0) Binds And Destabilizes M Raf Activation Signaling (through RasGRP Direct P53 Effectors RAF Activation TGF Beta Receptor Trk Receptor Signaling Mediated By The M P53 Pathway Feedback Loops 2 Negative Regulation Of MAPK Pathway Ras Signaling In The CD4+ TCR Pathway TP53 Regulates Metabolic Genes NGF Signaling Pathway ( NGF Signaling Pa G2/M DNA Damage Checkpoint// Processing FGF8 Signaling Pathway(Mouse) ( FGF8 Sig Regulation Of TP53 Activity Through Phos Raf Activation Signaling (through Grb2 A TP53 Regulates Transcription Of DNA Repa C MYC Pathway Growth Hormone Signaling Pathway(JAK2 ST TP53 Network MAPK1 (ERK2) Activation TP53 Regulates Transcription Of Death Re MAPK3 (ERK1) Activation Senescence And Autophagy In Cancer BCR P53 Pathway Feedback Loops 1 Drosophila Toll Like Receptor Signaling Heterotrimeric GPCR Signaling Pathway (t TP53 Regulates Transcription Of Genes In EGFR1 TP53 Regulates Transcription Of Genes In Integrin Signaling Pathway ( Integrin Si TP53 Regulates Transcription Of Caspase Energy Dependent Regulation Of MTOR By L TP53 Regulates Transcription Of Several MAP3K8 (TPL2) Dependent MAPK1/3 Activati MTOR Signalling Stabilization Of P53 MTORC1 Mediated Signalling Regulation Of TP53 Activity Through Asso Class IB PI3K Non Lipid Kinase Events Regulation Of TP53 Activity Through Acet Signaling By FGFR2 IIIa TM P53 Pathway By Glucose Deprivation Constitutive Signaling By AKT1 E17K In C Class I PI3K Signaling Events Mediated B Regulation Of TP53 Activity Through Meth P38 MAPK Pathway Regulation Of TP53 Degradation FGFR2b Ligand Binding And Activation TP53 Regulates Transcription Of Genes In JNK Cascade ( EGF Signaling Pathway Diag P53 Pathway FGFR2c Ligand Binding And Activation TP53 Regulates Transcription Of Addition Activated Point Mutants Of FGFR2// Phosp PRAD SKCM KIRC THCA COREAD GBM HNSC L BRCA O U V JAK/STAT Signaling Pathway AD MyD88 Dependent Cascade Initiated On End GRB2:SOS Provides Linkage To MAPK Signal P130Cas Linkage To MAPK Signaling For In Signaling By FGFR3 Fusions In Cancer Signaling By FGFR4 In Disease Signaling By FGFR2 In Disease Constitutive Signaling By EGFRvIII Constitutive Signaling By Ligand Respons Signaling By FGFR3 Point Mutants In Canc Inducing Angiogenesis FGF Signaling Pathway ( FGF Signaling Pa IGF1 Signaling Pathway ( IGF1 Signaling Interleukin Signaling Pathway -log10 Angiogenesis PDGF Signaling Pathway pval Integrin Signalling Pathway Hypoxic And Oxygen Homeostasis Regulatio 15 Signaling Events Mediated By Focal Adhes Pre NOTCH Transcription And Translation CDC42 Signaling Events Signaling Events Mediated By VEGFR1 And PDGF Signaling Pathway ( PDGF Signaling AKT(PKB) Bad Signaling ( EPO Signaling P VEGFR2 Mediated Cell Proliferation T Cell Activation PDGF Signaling Pathway (Mammal) ( PDGF S 10 VEGF Signaling Pathway Tie2 Signaling Downstream Signaling In Naïve CD8+ T Cel Loss Of Function Of FBXW7 In Cancer And Ras Pathway NOTCH1 Intracellular Domain Regulates Tr Prolactin ErbB1 Downstream Signaling Regulation Of Gene Expression By Hypoxia 5 Insulin Receptor Signaling ( Insulin Rec Constitutive Signaling By NOTCH1 HD Doma PDGFR Beta Signaling Pathway Constitutive Signaling By NOTCH1 T(7;9)( ErbB2/ErbB3 Signaling Events Activated NOTCH1 Transmits Signal To The Class I PI3K Signaling Events Pre NOTCH Processing In The Endoplasmic 0 Signaling By FGFR1 In Disease Constitutive Signaling By NOTCH1 HD+PEST Trk Receptor Signaling Mediated By PI3K G1 To S Cell Cycle Control Pre NOTCH Processing In Golgi Transcriptional Activation Of Cell Cycle HIF 2 Alpha Transcription Factor Network Constitutive Signaling By Aberrant PI3K Oxygen Dependent Proline Hydroxylation O PI5P, PP2A And IER3 Regulate PI3K/AKT Si Neurophilin Interactions With VEGF And V PIP3 Activates AKT Signaling VEGF And VEGFR Signaling Network// VEGF PI3K Events In ERBB2 Signaling [CGB Protein Results In Increased Activi ERBB2 Regulates Cell Motility ErbB Receptor Signaling Network JNK Cascade ( EGF Signaling Pathway Diag ERBB2 Activates PTK6 Signaling// Signali VEGFR2 Mediated Vascular Permeability RAF/MAP Kinase Cascade PDGF Pathway PI3 Kinase Pathway Canonical Wnt Signaling Pathway ErbB4 Signaling Events PDGF Receptor Signaling Network IL2 Signaling Events Mediated By PI3K PTK6 Promotes HIF1A Stabilization G Beta:gamma Signalling Through PI3Kgamm Signaling By PDGF PI3K Cascade PI3K Events In ERBB4 Signaling Hypoxia Response Via HIF Activation AKT(PKB) Activation Signaling ( IGF1 Sig PDGFR Alpha Signaling Pathway PI3K/AKT Activation AKT(PKB) Activation Signaling ( IGF1 Sig CD28 Dependent PI3K/Akt Signaling VEGFR3 Signaling In Lymphatic Endotheliu AKT(PKB) Activation Signaling ( Insulin Wnt Signaling Pathway FGF Signaling Pathway Angiopoietin Receptor Tie2 Mediated Sign Phosphorylation Of Proteins Involved In Signaling By EGFR VEGFR1 Specific Signals AKT(PKB) MTOR Signaling ( Insulin Recept Integrins In Angiogenesis Cyclin A:Cdk2 Associated Events At S Pha VEGFA VEGFR2 Pathway Negative Regulation Of The PI3K/AKT Netw PDGFR Beta Signaling Pathway Integrated Breast Cancer Pathway VEGF Signaling Pathway Validated Targets Of C MYC Transcription AKT(PKB) Bad Signaling ( EPO Signaling P TP53 Regulates Transcription Of Genes In ErbB Signaling Pathway Signaling Events Mediated By VEGFR1 And TP53 Regulates Transcription Of Addition Angiogenesis PDGF Signaling Pathway BRCA GBM HNSC O KIRC PRAD COREAD SKCM L THCA COREAD HNSC BRCA GBM KIRC O PRAD THCA L TP53 Regulates Transcription Of Genes In SKCM U U V V AD AD.
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