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Fluoride (Developmental Neurotoxicity and Endocrine Disruption)
Bill Osmunson DDS, MPH November 6, 2015 [email protected] Dr. Kristina Thayer Director, Office of Health Assessment and Translation National Toxicology Program Email: [email protected] (1) DATA ON CURRENT PRODUCTION, USE PATTERNS, AND HUMAN EXPOSURE A. The FDA approved fluoride toothpaste caution, “Do Not Swallow.” No safe dosage or amount is stated. “Do Not Swallow” is simple to understand. Use a pea or smear size and if more than used for brushing is swallowed, contact the poison control center. A quarter milligram of fluoride is in a pea size of fluoride toothpaste, the same amount found in each 11 oz glass of 0.7 ppm fluoridated public water. Fluoridated water is dispensed to everyone without regards for other fluoride exposures, individual consent, health, or sensitivity. The only safe amount of fluoride is, “Do Not Swallow.” Swallowing fluoride is not safe, however, many children swallow their toothpaste due to taste and the swallow reflex is part of the spitting action. B. Fluoridated water is the primary source of fluoride for many people. Fluoridated toothpaste is considered the second primary source and for some is more than fluoridated water. Other significant sources of fluoride include bone meal, mechanically deboned meat, grape products with cryolite, several legend drugs and sulfuryl fluoride, a post harvest fumigant. C. The FDA sent a letter to about 35 fluoride supplement manufacturers, “. there is no substantial evidence of drug effectiveness as prescribed, recommended or suggested in its labeling. .” (Drug Therapy -
Residual Fluoride in Food Fumigated with Sulfuryl Fluoride
Fluoride 2005;38(3):175–177 Editorial 175 RESIDUAL FLUORIDE IN FOOD FUMIGATED WITH SULFURYL FLUORIDE SUMMARY: New US federal allowances for inorganic fluoride residues in food fumigated with sulfuryl fluoride are excessively high and are at levels known to cause serious adverse health effects, including crippling skeletal fluorosis. Fluoride in food has long been recognized as a potential source of adverse health effects including dental fluorosis, bone and joint defects, gastrointestinal disturbances, and muscular-neurological disorders,1-2 plus even crippling skeletal fluorosis.3 In China, food contaminated by fluoride (F) from unvented coal burning used to dry and preserve grains and other crops is an important source of F intake,4 and F levels from such exposure ranging from 18 to 87 ppm in corn and 114 to 1109 ppm in chili have been reported.5 In these coal-burning F-endemic areas, even with very little F in the drinking water, the total daily F intake by affected adults has been estimated to be between 6.12 and 9.65 mg, with the major contribution coming from food.5 By contrast, in non-endemic areas, daily F intake was estimated to be only 0.8 mg/day.5 Therefore, any appreciable increase in F intake resulting from commercial food fumigation procedures can only be viewed with grave concern. In place of methyl bromide as an insecticide fumigant because of its upper atmosphere ozone depleting ability, a number of substitutes are already in use with varying results. For example, various combinations of phosphine (PH3) and carbon dioxide have been fairly successful for food as well as general fumigation, although equipment corrosion from phosphine and insect resistance to it are among its drawbacks. -
( 12 ) United States Patent
US009853326B2 (12 ) United States Patent ( 10 ) Patent No. : US 9 ,853 , 326 B2 Tokuda et al. ( 45 ) Date of Patent: Dec. 26 , 2017 ( 54 ) NONAQUEOUS ELECTROLYTE FOR (58 ) Field of Classification Search SECONDARY BATTERY AND CPC .. .. HO1M 10 /0569 ; HOTM 10 /0567 ; HOLM NONAQUEOUS - ELECTROLYTE 10 /0525 ; HOTM 4 /587 ; HOTM 4 / 134 ; SECONDARY BATTERY EMPLOYING THE HO1M 2300 /0025 ; YO2E 60 / 122 SAME See application file for complete search history . References Cited ( 71 ) Applicant: MITSUBISHI CHEMICAL (56 ) CORPORATION , Chiyoda- ku ( JP ) U . S . PATENT DOCUMENTS 5 ,580 ,684 A 12 / 1996 Yokoyama et al . (72 ) Inventors : Hiroyuki Tokuda, Ibaraki ( JP ) ; 5 , 754 , 393 A 5 / 1998 Hiratsuka et al. Minoru Kotato , Ibaraki ( JP ) ; Masahiro 6 ,001 , 325 A 12 / 1999 Salmon et al. Takehara , Ibaraki ( JP ) ; Shinichi 6 ,033 , 808 A 3 / 2000 Salmon et al. Kinoshita , Ibaraki ( JP ) 6 , 436, 582 B1 8 / 2002 Hamamoto et al. 6 , 919, 145 B1 7 / 2005 Kotato et al . 2001/ 0044051 AL 11/ 2001 Hamamoto et al. ( 73 ) Assignee : MITSUBISHI CHEMICAL 2002 / 0192564 Al 12 /2002 Ota et al. CORPORATION , Chiyoda -ku ( JP ) 2004 / 0048164 Al 3 /2004 Jung et al . 2004 / 0091786 A1 5 / 2004 Unoki et al. 2004 / 0191636 A1 9 / 2004 Kida et al . ( * ) Notice: Subject to any disclaimer , the term of this 2005 / 0008939 A1 1 / 2005 Ota et al. patent is extended or adjusted under 35 2005 /0014071 A1 1 / 2005 Noda et al. U . S . C . 154 ( b ) by 412 days. 2005 / 0084765 A1 4 / 2005 Lee et al . 2005 / 0118512 Al 6 / 2005 Onuki et al . -
INDEX to PESTICIDE TYPES and FAMILIES and PART 180 TOLERANCE INFORMATION of PESTICIDE CHEMICALS in FOOD and FEED COMMODITIES
US Environmental Protection Agency Office of Pesticide Programs INDEX to PESTICIDE TYPES and FAMILIES and PART 180 TOLERANCE INFORMATION of PESTICIDE CHEMICALS in FOOD and FEED COMMODITIES Note: Pesticide tolerance information is updated in the Code of Federal Regulations on a weekly basis. EPA plans to update these indexes biannually. These indexes are current as of the date indicated in the pdf file. For the latest information on pesticide tolerances, please check the electronic Code of Federal Regulations (eCFR) at http://www.access.gpo.gov/nara/cfr/waisidx_07/40cfrv23_07.html 1 40 CFR Type Family Common name CAS Number PC code 180.163 Acaricide bridged diphenyl Dicofol (1,1-Bis(chlorophenyl)-2,2,2-trichloroethanol) 115-32-2 10501 180.198 Acaricide phosphonate Trichlorfon 52-68-6 57901 180.259 Acaricide sulfite ester Propargite 2312-35-8 97601 180.446 Acaricide tetrazine Clofentezine 74115-24-5 125501 180.448 Acaricide thiazolidine Hexythiazox 78587-05-0 128849 180.517 Acaricide phenylpyrazole Fipronil 120068-37-3 129121 180.566 Acaricide pyrazole Fenpyroximate 134098-61-6 129131 180.572 Acaricide carbazate Bifenazate 149877-41-8 586 180.593 Acaricide unclassified Etoxazole 153233-91-1 107091 180.599 Acaricide unclassified Acequinocyl 57960-19-7 6329 180.341 Acaricide, fungicide dinitrophenol Dinocap (2, 4-Dinitro-6-octylphenyl crotonate and 2,6-dinitro-4- 39300-45-3 36001 octylphenyl crotonate} 180.111 Acaricide, insecticide organophosphorus Malathion 121-75-5 57701 180.182 Acaricide, insecticide cyclodiene Endosulfan 115-29-7 79401 -
IE-BPA 70185 Authorisation Cert Ver1.1.Pdf
AUTHORISATION NUMBER: IE/BPA 70185 EUROPEAN COMMUNITIES (AUTHORISATION, PLACING ON THE MARKET, USE AND CONTROL OF BIOCIDAL PRODUCTS) REGULATIONS CERTIFICATE OF AUTHORISATION The Competent Authority for Biocides in Ireland, pursuant to the provisions of the European Communities (Authorisation, Placing on the Market, Use and Control of Biocidal Products) Regulations, 2001, (S.I. 625 of 2001, as amended), grants authorisation to: Rentokil Initial Limited Hazel House Millennium Park Naas Co Kildare Ireland to place the biocidal product: Rentokil N2 Controlled Atmosphere on the market in Ireland, subject to the conditions detailed in the Annexes to this certificate. ==================================================================== Authorisation granted on behalf of the Competent Authority for Biocides in Ireland by Pesticide Registration and Control Division, (PRCD). Date of authorisation: 31 October 2012 Official Stamp: Ver: 1.1 Authorisation No.: IE/BPA 70185 ANNEX I Conditions and Product Summary This authorization may be subject to review in accordance with the European Communities (Authorisation, Placing on the Market, Use and Control of Biocidal Products) Regulations, 2001, (S.I. 624 of 2001, as amended). The outcome of such a review may lead to amendments to or the revocation of this authorization. The following conditions apply: 1. This product is only authorised for use by Professional trained staff of Rentokil and is not available to amateurs and the general public. 2. Product may not be placed on the Irish Market unless it is complies with the Annexes of this authorisation. 3. The requirements and conditions, specified in the Annexes, of this authorisation may not be altered without prior approval of modifications by the Irish Competent Authority for Biocides in Ireland. -
Taxonomy, Biogeography, and Notes on Termites (Isoptera: Kalotermitidae, Rhinotermitidae, Termitidae) of the Bahamas and Turks and Caicos Islands
SYSTEMATICS Taxonomy, Biogeography, and Notes on Termites (Isoptera: Kalotermitidae, Rhinotermitidae, Termitidae) of the Bahamas and Turks and Caicos Islands RUDOLF H. SCHEFFRAHN,1 JAN KRˇ ECˇ EK,1 JAMES A. CHASE,2 BOUDANATH MAHARAJH,1 3 AND JOHN R. MANGOLD Ann. Entomol. Soc. Am. 99(3): 463Ð486 (2006) ABSTRACT Termite surveys of 33 islands of the Bahamas and Turks and Caicos (BATC) archipelago yielded 3,533 colony samples from 593 sites. Twenty-seven species from three families and 12 genera were recorded as follows: Cryptotermes brevis (Walker), Cr. cavifrons Banks, Cr. cymatofrons Schef- Downloaded from frahn and Krˇecˇek, Cr. bracketti n. sp., Incisitermes bequaerti (Snyder), I. incisus (Silvestri), I. milleri (Emerson), I. rhyzophorae Herna´ndez, I. schwarzi (Banks), I. snyderi (Light), Neotermes castaneus (Burmeister), Ne. jouteli (Banks), Ne. luykxi Nickle and Collins, Ne. mona Banks, Procryptotermes corniceps (Snyder), and Pr. hesperus Scheffrahn and Krˇecˇek (Kalotermitidae); Coptotermes gestroi Wasmann, Heterotermes cardini (Snyder), H. sp., Prorhinotermes simplex Hagen, and Reticulitermes flavipes Koller (Rhinotermitidae); and Anoplotermes bahamensis n. sp., A. inopinatus n. sp., Nasuti- termes corniger (Motschulsky), Na. rippertii Rambur, Parvitermes brooksi (Snyder), and Termes http://aesa.oxfordjournals.org/ hispaniolae Banks (Termitidae). Of these species, three species are known only from the Bahamas, whereas 22 have larger regional indigenous ranges that include Cuba, Florida, or Hispaniola and beyond. Recent exotic immigrations for two of the regional indigenous species cannot be excluded. Three species are nonindigenous pests of known recent immigration. IdentiÞcation keys based on the soldier (or soldierless worker) and the winged imago are provided along with species distributions by island. Cr. bracketti, known only from San Salvador Island, Bahamas, is described from the soldier and imago. -
Sound Management of Pesticides and Diagnosis and Treatment Of
* Revision of the“IPCS - Multilevel Course on the Safe Use of Pesticides and on the Diagnosis and Treatment of Presticide Poisoning, 1994” © World Health Organization 2006 All rights reserved. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either expressed or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall the World Health Organization be liable for damages arising from its use. CONTENTS Preface Acknowledgement Part I. Overview 1. Introduction 1.1 Background 1.2 Objectives 2. Overview of the resource tool 2.1 Moduledescription 2.2 Training levels 2.3 Visual aids 2.4 Informationsources 3. Using the resource tool 3.1 Introduction 3.2 Training trainers 3.2.1 Organizational aspects 3.2.2 Coordinator’s preparation 3.2.3 Selection of participants 3.2.4 Before training trainers 3.2.5 Specimen module 3.3 Trainers 3.3.1 Trainer preparation 3.3.2 Selection of participants 3.3.3 Organizational aspects 3.3.4 Before a course 4. -
California Restricted Materials Requirements (English)
CALIFORNIA RESTRICTED MATERIALS REQUIREMENTS FEDERAL RESTRICTED USE PESTICIDES RESTRICTED USE PESTICIDE A (Included by reference as California Restricted Materials) DUE TO (reason for restricted use classification) Pesticides display the RESTRICTED USE PESTICIDE (RUP) statement on For retail sale to and use only by Certified Applicators or the pesticide container similar to the statement shown here. RUPs require an persons under their direct supervision and only for those RUP statement enclosed in a box, at the top of the front panel of the label. uses covered by the Certified Applicator's certification. Some product labels require a Certified Applicator be “physically present” at the use site. B CALIFORNIA RESTRICTED MATERIALS This section is written in a quick reference format; refer to Title 3, California Code of Regulations (3 CCR) section 6400 for complete text. Acrolein, labeled for use as an aquatic Chlorpyrifos, labeled for the Metam sodium, labeled for the Potassium n-methyldithiocarbamate herbicide production of an agricultural production of agricultural plant (metam-potassium), labeled for the Aldicarb – unregistered commodity commodities production of agricultural plant All dust (except products containing Dazomet, labeled for the production Methamidophos – unregistered commodities only exempt pesticides)** of agricultural plant commodities Methidathion Propanil (3,4-dichloropropionanilide) Aluminum phosphide Dicamba* Methomyl†† Sodium cyanide Any pesticide containing active 2,4-dichlorophenoxyacetic acid Methyl bromide Sodium -
RRAC Guidelines on Anticoagulant Rodenticide Resistance Management Editor: Rodenticide Resistance Action Committee (RRAC) of Croplife International Aim
RRAC guidelines on Anticoagulant Rodenticide Resistance Management Editor: Rodenticide Resistance Action Committee (RRAC) of CropLife International Aim This document provides guidance to advisors, national authorities, professionals, practitioners and others on the nature of anticoagulant resistance in rodents, the identification of anticoagulant resistance, strategies for rodenticide application that will avoid the development of resistance and the management of resistance where it occurs. The Rodenticide Resistance Action Committee (RRAC) is a working group within the framework of CropLife International. Participating companies include: Bayer CropScience, BASF, LiphaTech S. A., PelGar, Rentokil Initial, Syngenta and Zapi. Senior technical specialists, with specific expertise in rodenticides, represent their companies on this committee. The RRAC is grateful to the following co-authors: Stefan Endepols, Alan Buckle, Charlie Eason, Hans-Joachim Pelz, Adrian Meyer, Philippe Berny, Kristof Baert and Colin Prescott. Photos provided by Stefan Endepols. Contents 1. Introduction ............................................................................................................................................................................................................. 2 2. Classification and history of rodenticide compounds ..............................................................................................3 3. Mode of action of anticoagulant rodenticides, resistance mechanisms, and resistance mutations ......................................................................................................6 -
Integrated Pest Management Procedure Manual
SSC Facilities Services at Texas A&M University Integrated Pest Management Procedure Manual revised 6/2018 INTEGRATED PEST MANAGEMENT PROCEDURE MANUAL SSC Services for Education 600 Agronomy Road College Station, Texas 77843 Written by: Amanda J. Bakken Under the direction of: Bryan McGee Layout and Design by: Barbara Musgrove PURPOSE OF BOOK The purpose of this Integrated Pest Management (IPM) book is to educate pest management technicians and the Texas A&M University (TAMU) campus on the newly adopted IPM plans and policies. This book includes the IPM policies, objectives, recordkeeping, and requirements that will be used by technicians. This book is not comprehensive, but an ongoing work in progress that is meant to be updated as more effective techniques, technologies, and methods become available to properly maintain and prevent pests. Pest-specific examples, including visual references, are given and should be referenced as needed. SSC Services for Education and TAMU take the safety and well-being of students, faculty, staff, and visitors seriously. Dangers associated with pesticides exist to humans, animals, and the environment, but by following this plan many of these risks can be mitigated and effective management of pests and diseases can be exacted. DEFINITION OF IPM AND PROCEDING POLICIES Integrated Pest Management, or IPM, is an ecosystem-based strategy that focuses on long-term prevention of pests or their damage through a combination of techniques. Techniques include mechanical control, genetic manipulation and control, regulatory practices, biological control, habitat manipulation, modification of cultural practices, and use of resistant varieties of plants. Pesticides are used only after surveillance and/or monitoring indicates they are needed. -
U.S. EPA, Pesticides, Label, GASTOXIN FUMIGATION TABLETS
EPA Reg. Date of u.s. ENVIRONMENTAL Number: Issuance: PROTECTION AGENCY Office of Pesticide Programs Registration Division (7505P) 43743-1 JlJl- 82010 1200 Pennsylvania Ave., N.W. Washington, D.C. 20460 Terms of Issuance: Unconditional NOTICE OF PESTICIDE: __ Registration XX Reregistration Name of Pesticide Product: (under FIFRA, as amended) GastoxinR ~.~J~OVl Tablets Name and Address of Registrant (include ZXP Code): Bernardo Chemicals, Inc. P.O. Box 1632 Turlock, CA 95381 Note: Changes in labeling differing in substance from that accepted in connection with this registration must be submitted to and accepted by the Registration Division prior to use of the label in commerce. In any correspondence on this product always refer to the above EPA registration number. On the basis of information furnished by the registrant, the above named pesticide is hereby reregistered under the Federal Insecticide, Fungicide and Rodenticide Act. Registration is in no way to be construed as an endorsement or recommendation of this product by the Agency. In order to protect health and the environment, the Administrator, on his motion, may at any time suspend or cancel the registration of a pesticide in accordance with the Act. The acceptance of any name in connection with the registration of a product under this Act is not to be construed as giving the registrant a right to exclusive use of the name or to its use if it has been covered by . others. Based on your response to the Reregistration Eligibility Document, EPA has reregistered the product listed above. This action is taken under the authority of section 4(g)(2)(c) of the Federal Insecticide, Fungicide, and Rodenticide Act, as amended. -
Insect-Mediated Nitrogen Dynamics in Decomposing Wood
Ecological Entomology (2015), 40 (Suppl. 1), 97–112 DOI: 10.1111/een.12176 INSECTS AND ECOSYSTEM SERVICES SPECIAL ISSUE Insect-mediated nitrogen dynamics in decomposing wood MICHAEL D. ULYSHEN USDA Forest Service, Athens, Georgia, U.S.A. Abstract. 1. Wood decomposition is characterised by complex and poorly understood nitrogen (N) dynamics with unclear implications for forest nutrient cycling and productivity. Wood-dwelling microbes have developed unique strategies for coping with the N limitations imposed by their substrate, including the translocation of N into wood by cord-forming fungi and the fixation of atmospheric nitrogen2 (N ) by bacteria and Archaea. 2. By accelerating the release of nutrients immobilised in fungal tissues and promoting N2 fixation by free-living and endosymbiotic prokaryotes, saproxylic insects have the potential to influence N dynamics in forests. 3. Prokaryotes capable of fixing N2 appear to be commonplace among wood-feeding insects, with published records from three orders (Blattodea, Coleoptera and Hymenoptera), 13 families, 33 genera and at least 60 species. These organisms appear to play a significant role in the N economies of their hosts and represent a widespread solution to surviving on a diet of wood. 4. While agricultural research has demonstrated the role that termites and other insects can play in enhancing crop yields, the importance of saproxylic insects to forest productivity remains unexplored. Key words. Arthropods, diazotroph, ecosystem services, Isoptera, mineralisation, saproxylic, symbiosis. Introduction the N-rich tissues of particular insect and fungal species. For example, Baker (1969) reported that Anobium punctatum (De Nitrogen (N) is the limiting nutrient in many systems (Vitousek Geer) developing in dry wood acquired 2.5 times the amount & Howarth, 1991; LeBauer & Treseder, 2008) and this is espe- of N provided by the wood itself.