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Eye Research – an Equal Partner’ 2020 ‘EYE RESEARCH – AN EQUAL PARTNER’ 2020 Eye Research – an equal partner A Report entitled “Eye Research – an equal partner”, compiled and edited by Julian Jackson, featuring contributions from leading researchers in the UK Julian Jackson - Director, Vision Bridge 17/09/2020 1 ‘EYE RESEARCH – AN EQUAL PARTNER’ 2020 Table of Contents 1.0 Introduction 2.0 Understanding the patterns and processes of disease 2.1 Harnessing Human Diversity to Better Understand and Treat Immune Mediated Ocular Diseases 2.2 The case for ‘basic science’ 2.3 Building a Living Lens to Fight Diseases of the Eye 2.4 Eye Related Research 2.5 Harnessing genetic information to discover what causes myopia 2.6 Challenges and therapeutic opportunities for Age-related Macular Degeneration 2.7 The importance of earlier interventions and alternative treatments 2.8 Major advances in genomic research in ophthalmology 2.9 The pre-Descemet’s layer and its relationship with the trabecular meshwork 2.10 If there is no struggle, there is no progress 2.11 From basic cell biology to ocular disease and new therapies 2.12 Taking care of your eyes – the hidden risk of ionizing radiation 2.13 Partner Diagnostics and Therapeutics for genetic eye disease 2.14 Alternative models for studying complex diseases 2.15 Understanding the role of the immune system in eye disease 2.16 Understanding Biology to Develop Novel Therapies or Molecular Therapies for Ocular Scarring 2.17 Understanding disease mechanisms with post mortem eye disease models 2.18 Understanding response, repair and regeneration mechanisms in ocular tissue to improve treatments and patient care 2.19 Studying gene-gene interaction and gene-environment interaction in support of preventative therapies 2.20 Understanding disease mechanisms to improve selection of treatments, identify targets for therapy and increase personalisation of therapies 2.21 Complement as a driver of Age-related Macular Degeneration 3.0 Detection, diagnosis and monitoring 3.1 Redesigning perimetry to improve accuracy, precision, and efficiency of the test for glaucoma 3.2 Organisations partnering to improve detection, diagnosis, treatment and personalised healthcare with large- scale data sets 3.3 Arclight – Less Is More 3.4 The potential of machine learning and possible future clinical applications 3.5 The importance of accurate measurements to improve personalisation of treatments and management regimes for glaucoma 3.6 Telemedicine or Teleophthalmology 3.7 Smartphone Eye Camera 3.8 The new Visual Fixation System – grabbing attention just when you need it 3.9 Digital technologies to transform care for patients with Age-related Macular Degeneration 3.10 Home monitoring of vision to increase convenience for patients and capacity in secondary care 3.11 Cuttlefish to clinic: blue sea research leads to innovative new technique to assess a key risk factor for Age- related Macular Degeneration (AMD) 3.12 Preventable vision loss: A global challenge – NovaSight 3.13 Enhancing glaucoma detection with a novel technique to image and track individual retinal cell death 2 ‘EYE RESEARCH – AN EQUAL PARTNER’ 2020 3.14 Translation of Ophthalmic Technology to Enhance Patient’s Vision 3.15 Providing appropriate eye care for children and adults with learning disabilities 3.16 Challenging conventional wisdom to improve sight tests for nystagmus 3.17 An unhealthy diet causes small changes in eye cells leading to sight-loss 3.18 Correcting mitochondrial decline and improving retinal function – implications for AMD as it reduces inflammation 3.19 The flexibility of OCT and the accommodation of underrepresented groups 3.20 Handheld Oximetric Ophthalmoscope for Enhanced Diagnosis of Retinopathy of Prematurity 3.21 Seeing what they see: Compensating for cortical visual dysfunction in Alzheimer’s disease 3.22 Imaging – a powerful illustration of innovation 3.23 An innovative testing and monitoring regime yielding results 3.24 How the application of machine learning and artificial intelligence (AI) can assist in the speed and quality of diagnosis 3.25 A collaborative approach to improve visual field tests 3.26 The importance and translational benefits of improving the accuracy of diagnostic tests 3.27 A new way of detecting and monitoring eye disease 4.0 Treatments 4.1 Synthetic microbicidal peptides: A novel therapy for the management of corneal blindness 4.2 The development of novel oculosubarachnoid glaucoma shunt devices (OGDs) 4.3 SAVIR-Therapy for vision restoration – Vision recovery and reactivation of “silent” neurons 4.4 Research towards a revolutionary drug delivery mechanism for AMD treatment and prevention strategies 4.5 Intraocular Magnifying Lenses for Advanced Macular Disease – Current Status 4.6 New research findings in corneal biology from Newcastle team that are driving innovative treatments for blindness 4.7 Glaucoma Care in the Blink of an Eye 4.8 Partner Diagnostics and Therapeutics for genetic eye disease 4.9 Novel ways to deliver immunotherapies in drop form for Age-related Macular Degeneration 4.10 Circadian Therapeutics – Tackling the problem of circadian rhythm disruption 4.11 Development of anti-fibrotic treatments for Primary Open angle glaucoma 4.12 The need to move from rehabilitation to effective treatment strategies for rare eye diseases 4.13 Improving the treatment of retinal diseases through new injectable polymer technologies 4.14 Combating corneal infections with innovative agents 4.15 Reversing Type 2 Diabetes Proved to be Possible 4.16 Latest developments in sight-saving corneal therapies 4.17 Advancing visualisation in vitreoretinal surgery with light-field imaging 4.18 Cell therapy for cure of corneal blindness 4.19 Improving Surgical Dexterity and Speed 4.20 Testing novel therapies 4.21 Bioengineering – the ability to rethink models of treatment and care 4.22 Model eyes that enhance the safety and efficacy of surgical training 4.23 Gene therapy – prevention therapy supported by early diagnosis 4.24 Stem cell therapy for retinal degeneration 4.25 Operating microscope with integrated OCT helping to refine surgical procedures in gene therapy 4.26 Gene therapy options for AMD 4.27 MicroPulse laser for drusen removal 3 ‘EYE RESEARCH – AN EQUAL PARTNER’ 2020 4.28 Alternative treatment for glaucoma to circumvent shortfalls in drugs and surgery 4.29 Repurposing a drug 4.30 Translational research for blinding surface diseases of the eye – including the cornea 4.31 Nutrition that enhances vision in patients with retinal disease 4.32 Pharmacogenetics: facts, estimate of potential and benefits of implementation in ophthalmology 4.33 Surgical innovation – providing effective alternative treatments for glaucoma 4.34 The path from scientific research to a marketed medicine 4.35 Glaucoma: Translating Science into Solutions 4.36 The potential of stem cell therapy in retinal disease 4.37 Protecting and regenerating the optic nerve in glaucoma with gene and stem cell therapies 4.38 A drug delivery platform that empowers patients and reduces costs and pressures in the NHS 5.0 Rehabilitation 5.1 Understanding user requirements to build better Low Vision Aids 5.2 Voxmate – a blind-first, gesture-based app for Android 5.3 Colour tents – reducing clutter and over-stimulation leading to improvements in visual awareness and attention 5.4 RightHear technology – turning public and private spaces into accessible environments for the visually impaired 5.5 The Owlett – A camera to help the visually impaired around the house 5.6 The Ocutrx Oculenz headset – see around your blind spot, ignore your scotoma, improve your quality of life! 5.7 Falcon Autofocus bioptic – Supporting visual needs while interfering the least with habitual behaviour 5.8 NuEyes Technologies – a leader in head worn assistive technology devices. 5.9 Empowering Visually Impaired people – NaviLens 5.10 Improving quality of life and health outcomes through increased interdisciplinary competency and health literacy of vision and vision rehabilitation 5.11 Towards a Cortical Visual Neuroprosthesis for the Blind: CORTIVIS Approach 5.12 Acesight wearable electronic glasses help people with low vision see the world around them 5.13 Exploring The Use of Smart Camera Technologies For Adults With Acquired Visual and/or Language Impairments 5.14 Envision AI – Enabling Vision For The Visually Impaired 5.15 The Clew App: Leveraging Augmented Reality Technology for Orientation and Mobility 5.16 Can training to use smartphones and tablets improve quality of life for individuals with visual impairment? 5.17 Orthoptic research spanning assessment, diagnosis and treatment leading to improved patient care 5.18 EVA – Extended Visual Assistant 5.19 Transforming Lives Through Technology 5.20 Apps and accessibility: what is new in technology for people with low vision 5.21 More clinical evidence about visual improvements of wearable low vision aids 5.22 A revolution in assistive technology: About OrCam MyEye 5.23 The importance of reading tests and rehabilitation techniques 5.24 Prototype Smart homes for the visually impair 5.25 An example of rehabilitation technology from abroad 4 ‘EYE RESEARCH – AN EQUAL PARTNER’ 2020 6.0 Patients 6.1 Digital Innovation at Moorfields 6.2 Seeing Beyond The Eyes – Empowering Professionals to Support Patients with Sight Loss 6.3 Involving children, young people and their families in designing and running research projects 6.4 The real impact of cataract on our society and health in general 6.5 Patient Power – it actually works! 6.6 Fighting infection and changing behaviour 6.7 Understanding
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