DOCSLIB.ORG

(12) Patent Application Publication (10) Pub. No.: US 2008/0069871 A1 Vaughn Et Al

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
(12) Patent Application Publication (10) Pub. No.: US 2008/0069871 A1 Vaughn Et Al US 2008 OO69871 A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2008/0069871 A1 Vaughn et al. (43) Pub. Date: Mar. 20, 2008 (54) HYDROPHOBC ABUSE DETERRENT filed on Aug. 30, 2006. Provisional application No. DELIVERY SYSTEM 60/871,504, filed on Dec. 22, 2006. Provisional appli cation No. 60/824,057, filed on Aug. 30, 2006. Pro (76) Inventors: Jason M. Vaughn, Round Rock, TX visional application No. 60/903,235, filed on Feb. 22, (US); Michael M. Crowley, Austin, TX 2007. Provisional application No. 60/893,825, filed (US); Feng Zhang, Austin, TX (US); on Mar. 8, 2007. Provisional application No. 60/893, John J. Koleng, Austin, TX (US); 798, filed on Mar. 8, 2007. Justin M. Keen, Round Rock, TX (US); Justin R. Hughey, Austin, TX Publication Classification (US) (51) Int. Cl. Correspondence Address: A6II 47/30 (2006.01) MEYERTONS, HOOD, KIVLIN, KOWERT & A6II 47/38 (2006.01) GOETZEL, P.C. A6IR 9/14 (2006.01) P.O. BOX 398 A 6LX 9/52 (2006.01) AUSTIN, TX 78767-0398 (US) A6IP 25/04 (2006.01) (52) U.S. Cl. ......................... 424/456; 424/484; 424/487: (21) Appl. No.: 11/781,008 514/772.6; 514/781 (22) Filed: Jul. 20, 2007 (57) ABSTRACT Related U.S. Application Data Disclosed herein are oral dosage forms of therapeutic agents that are resistant to abuse and methods of their formulation. (60) Provisional application No. 60/820,091, filed on Jul. In particular, oral dosage forms that are resistant to disso 21, 2006. Provisional application No. 60/824,042, lution in aqueous solutions of ethanol are described. Patent Application Publication Mar. 20, 2008 Sheet 1 of 13 US 2008/0069871 A1 to cr) s s e d O ld O S S wn w eSeefe eIOZepluodleM% Patent Application Publication Mar. 20, 2008 Sheet 2 of 13 US 2008/0069871 A1 s S s S s s S S s S S eSeefe, fin IC 9% Patent Application Publication Mar. 20, 2008 Sheet 3 of 13 US 2008/0069871 A1 eSeele GnuO % Patent Application Publication Mar. 20, 2008 Sheet 4 of 13 US 2008/0069871 A1 O S & wn CY) S. Q Q O CN was Q S. O to o S O S. cy KNS s s s S S O S s eSeefe findG 9% Patent Application Publication Mar. 20, 2008 Sheet 5 of 13 US 2008/0069871 A1 O O. O. Q O. O. O. O. O O S O) OO N O lc). Yi cr) CN w CS eSeeley fin IG 9% Patent Application Publication Mar. 20, 2008 Sheet 6 of 13 US 2008/0069871 A1 O O. O. O. O. O. s O) OO N CO lic) Nr eSeefe fruO 9% Patent Application Publication Mar. 20, 2008 Sheet 7 of 13 US 2008/0069871 A1 g S S 8Seefe fin IC 9% Patent Application Publication Mar. 20, 2008 Sheet 8 of 13 US 2008/0069871 A1 S. S. S O S O v. CX lc) S CN l g O N O CN g S isS O) SN O w O Q Q Q Q O Q s O) CO, N, O O. W. C.) eSeefe, 6nuO % Patent Application Publication Mar. 20, 2008 Sheet 9 of 13 US 2008/0069871 A1 Q Q Q Q Q O O) OO N CO lay Nir eSeefe fin IG 9% Patent Application Publication Mar. 20, 2008 Sheet 10 of 13 US 2008/0069871 A1 s s s s S O S eSeeley findC 94 Patent Application Publication Mar. 20, 2008 Sheet 11 of 13 US 2008/0069871 A1 g O. O. O. O. O. O. O. O. O. O. S O) OO. N. O. l.c.) CS eSeefe fruG 9% Patent Application Publication Mar. 20, 2008 Sheet 13 of 13 US 2008/0069871 A1 cye 3 S s S O O S. S CN S eSeeled 6nuG 9% US 2008/0069.871 A1 Mar. 20, 2008 HYDROPHOBC ABUSE DETERRENT DELIVERY 0008. The difficulty in the art is that it is desirable among SYSTEM drug abusers to bypass the extended release characteristics of oral dosage forms. By negating the controlled release PRIORITY CLAIM mechanisms of the dosage form, the abuser is able to 0001) This application claims the benefit of U.S. Provi produce a quick and intense rush of drug into the brain that sional Application No. 60/820,091 entitled “Abuse Deter results in a high. Abusers have found many methods by rent Delivery System,” filed Jul. 21, 2006 and U.S. Provi which the extended release characteristics of certain oral sional Application No. 60/824,042 entitled “Hydrophobic dosage forms can be bypassed. These include: (i) intrave Abuse Deterrent Delivery System,” filed Aug. 30, 2006 and nous injection of dissolved tablets or capsules, (ii) inhala U.S. Provisional Application No. 60/871,504 entitled tion/nasal Snorting of crushed tablets or capsules, (iii) chew “Hydrophobic Abuse Deterrent Delivery System,” filed Dec. ing tablets or capsules and (iv) dissolving of tablets or 2, 2006 and U.S. Provisional Application No. 60/824,057 capsules in alcoholic beverages followed by oral adminis entitled “Hydrophilic Abuse Deterrent Delivery System” tration. filed Aug. 30, 2006 and U.S. Provisional Application No. 0009 Abuse of narcotic substances is particularly prob 60/903,235 entitled “Hydrophilic Abuse Deterrent Delivery lematic. Such drugs are highly habit forming when misused System” filed Feb. 22, 2007 and U.S. Provisional Applica and thus are in high demand by drug abusers. In contrast, tion No. 60/893,825 entitled “Hydrophobic Abuse Deterrent there are numerous legitimate users of narcotic Substances Delivery System For Opioid Agents' filed Mar. 8, 2007 and that need oral dosage forms that release large quantities of U.S. Provisional Application No. 60/893,798 entitled “Hydrophilic Abuse Deterrent Delivery System For Opioid narcotic over an extended period of time for the treatment of Agents' filed Mar. 8, 2007. extreme pain. 0010 Oral formulations that deter abuse have also been BACKGROUND OF THE INVENTION suggested. U.S. Pats. No. 5,747,058 and 5,968,542 and U.S. 0002) 1. Field of the Invention Publication No. 2004.01611382 disclose an oral drug deliv 0003. The invention generally relates to pharmaceutical ery system based on the use of therapeutic agents suspended delivery systems and methods of their use, in particular oral in high viscosity liquid carrier material. dosage systems for the delivery of drugs that are resistant to 0011. The U.S. Publication No. 2003.0118641 discloses abuse. controlled-release opioid delivery compositions that are resistant to extraction with commonly-available solvents. 0004 2. Description of the Relevant Art The formulation between 30 and 65% of a matrix forming 0005 Drug formulations for the oral delivery of pharma polymer and between 5 and 15% of an ionic exchange resin. ceuticals have been used for centuries. More recently, However the disclosed formulations are prepared as tablets numerous compositions and methods have been developed of compressed powder that can be readily crushed. This fails for the controlled release of pharmaceuticals after oral to deter methods of drug abuse involving nasal inhalation. delivery. Such extended-release characteristics can be useful 0012. Other abuse deterrent systems include oral dosage for many reasons. One reason is that extended-release deliv ery systems can limit the number of doses a patient must forms that include an opioid and an opioid antagonist that is take over a period of time thus improving compliance with released when the dosage form is tampered with. Examples a dosing regimen. Another reason is that extended release of this approach can be found at U.S. Pat. Nos. 6,696,088, delivery systems can provide a steady dose of medication to 6,696,066, 6,627,635, 6,326,027 and 6,228,863. a patient, thereby avoiding Sudden increases and decreases 0013 U.S. Publication No. 2004.0052731 discloses oral in the level of medication being delivered to the blood dosage forms of drugs that have been modified to increase stream. Controlled release of pharmaceuticals is particularly their lipophilicity entrapped in coated microparticles critical with drugs that are habit forming, as the controlled wherein the coatings render the microparticles insoluble or release of the medication can significantly reduce the like poorly soluble in various solvents. The formulations can still lihood of a patient developing an addiction to the Substance. be crushed, but the formulations are intended to prevent 0006. One common method of producing a controlled immediate release of the drug even when crushed. release oral dosage form is to Surround the drug with a 0014. Therefore there remains a significant need in the art coating or barrier of a hydrophobic Substance Such as a for oral dosage forms that are resistant to attempts by polymeric coating. These coatings or barriers can be potential abusers to bypass the controlled or extended designed to dissolve gradually when brought into contact release characteristics of conventional oral dosage forms. In with digestive fluids thus producing a slow and steady particular, oral dosage forms are needed that are resistant to release of a drug when it is ingested. crushing and dissolution in water or aqueous alcohol solu 0007. Other approaches that have been developed include tions such as alcoholic beverages. the methods disclosed in U.S. Pat. Nos. 6,261,599, 6,335, SUMMARY OF THE INVENTION 033, 6,706,281 and 6,743,442 wherein a drug is mixed with a water-insoluble retardant and optionally with binders 0015. In certain embodiments, the invention relates to and/or plasticizers. The mixture is then heated and extruded oral dosage forms of a therapeutic agent that are abuse into narrow Strands which are cut into particles having a size deterrent.
Load more

Recommended publications
  • Technical Developments in the Use of Spices Dr David Baines Baines Food Consultancy Ltd
    EUROPEAN SPICE ASSOCIATION GENERAL ASSEMBLY 2013 Technical Developments in the Use of Spices Dr David Baines Baines Food Consultancy Ltd Co-editor: Flavour Horizons TECHNICAL DEVELOPMENTS IN THE USE OF SPICES TOPICS: Recent health claims submitted to the EU for the use of spices Compounds in selected spices that have beneficial effects on health The use of spices to inhibit of carcinogen formation in cooked meats The growing use of spices in animal feeds Salt reduction using spices Interesting culinary herbs from Vietnam Recent Health Claims Submitted to the EU EU REGULATION OF HEALTH CLAIMS • The Nutrition and Health Claims Regulation, 1924/2006/EC is designed to ensure a high level of protection for consumers and legal clarity and fair competition for food business operators. • Claims must not mislead consumers; they must be, accurate, truthful, understandable and substantiated by science. • Implementation of this Regulation requires the adoption of a list of permitted health claims, based on an assessment by the European Food Safety Authority (EFSA) of the science substantiating the claimed effect and compliance with the other general and specific requirements of the Regulation. • This list of permitted health claims was adopted in May 2012 by the Commission and became binding on 14th December 2012. Food companies must comply from this date or face prosecution for misleading marketing. APPROVAL OF CLAIMS EU REGULATION OF HEALTH CLAIMS CLAIMS BY COMPONENT CLAIMS BY FUNCTION CLAIMS FOR SPICES – NOT APPROVED/ON HOLD SPICE CLAIM(S) Anise / Star Anise Respiratory Health, Digestive Health, Immune Health, Lactation Caraway Digestive Health, Immune Health, Lactation Cardamon Respiratory Health, Digestive Health, Immune Health, Kidney Health, Nervous System Health, Cardiovascular Health, Capsicum Thermogenesis, Increasing Energy Expenditure, Enhancing Loss of Calories, Body Weight Loss, Stomach Health, Reduction of Oxidative Stress, promotion of Hair Growth.
    [Show full text]
  • Tips to Roast Vegetables Spice Guide
    Tips to Roast Vegetables • Roast at a high oven temp- 400 to 450 degrees F • Chop vegetables in uniform size so they cook evenly • Don’t over crowd the pan, otherwise they will become soft • Roasting veggies with some oil will help them become crispier • To get the most flavor/crispier roast them on the top rack • Seasoning before putting them in the oven will add flavor • Flip veggies halfway through to ensure even cooking • When roasting multiple types of veggies, ensure they have similar cooking times. Good pairs include: Cauliflower and Broccoli cc Carrots and Broccoli Baby potatoes and Butternut Squash Onions and Bell Peppers Zucchini and Yellow Squash Asparagus and Leeks Spice Guide Table of Contents Spices by Cuisine Herbs and Spices 1 Mexican Coriander, Cumin, oregano, garlic powder, cinnamon, chili powder Herbs and Spices that Pair well with Proteins 2 Caribbean Chicken Fajita Bowl Recipe 3 All spice, nutmeg, garlic powder, cloves, cinnamon, ginger Shelf life of Herbs and Spices 4 French Nutmeg, thyme, garlic powder, rosemary, oregano, Herbs de Provence Spices by Cuisine 5 North African Tips to Roast Vegetables BP Cardamum, cinnamon, cumin, paprika, turmeric, ginger Cajun Cayenne, oregano, paprika, thyme, rosemary, bay leaves, Cajun seasoning Thai Basil, cumin, garlic, ginger, turmeric, cardamum, curry powder Mediterranean Oregano, rosemary, thyme, bay leaves, cardamum, cinnamon, cloves, coriander, basil, ginger Indian Bay leaves, cardamum, cayenne, cinnamon, coriander, cumin, ginger, nutmeg, paprika, turmeric, garam masala, curry powder Middle Eastern Bay leaves, cardamum, cinnamon, cloves, cumin, ginger, coriander, oregano, za’atar, garlic powder 5 Shelf Life of Herbs and Herbs and Spices Spices Herbs Herbs are plants that’s leaves can be used to add flavor to foods.
    [Show full text]
  • Activated Charcoal for Acute Poisoning: One Toxicologist's Journey
    J. Med. Toxicol. (2010) 6:190–198 DOI 10.1007/s13181-010-0046-1 REVIEW ARTICLE Activated Charcoal for Acute Poisoning: One Toxicologist’s Journey Kent R. Olson Published online: 20 May 2010 # The Author(s) 2010. This article is published with open access at Springerlink.com Keywords Activated charcoal . Gastrointestinal As summarized by Matthew [13], Harstad and Danish decontamination . Poisoning . Drug overdose colleagues reported in 1942 that relatively little phenobar- bital was recovered by lavage even shortly after overdose [14] and this, along with their finding of particles of When I began studying clinical toxicology in 1981, the issue charcoal in the lungs of patients who died, led them to call of gastrointestinal decontamination after acute ingestion for the abandonment of gastric lavage for poisoning.) “ ” seemed pretty well settled: universal antidote, apomor- In recent years, my colleagues and I have continued to – phine and salt wateremesiswerenolongerused[1, 2]; and I debate the value of various methods of gastric decontam- was taught that barring a specific contraindication, the awake ination and the role and risks of activated charcoal, and it is patient was given syrup of ipecac to induce emesis, and the clear to me that the issue remains muddy. Some have taken drowsy or uncooperative patient was lavaged [3]. After a firm stand that no treatment should be recommended that is gastric emptying, everyone received activated charcoal not supported by evidence from a randomized controlled trial (AC). The only controversy seemed to be over whether one (RCT). Position statements published jointly by the Amer- should add a cathartic to speed gastrointestinal transit [4].
    [Show full text]
  • The Stimulants and Hallucinogens Under Consideration: a Brief Overview of Their Chemistry and Pharmacology
    Drug and Alcohol Dependence, 17 (1986) 107-118 107 Elsevier Scientific Publishers Ireland Ltd. THE STIMULANTS AND HALLUCINOGENS UNDER CONSIDERATION: A BRIEF OVERVIEW OF THEIR CHEMISTRY AND PHARMACOLOGY LOUIS S. HARRIS Dcparlmcnl of Pharmacology, Medical College of Virginia, Virginia Commonwealth Unwersity, Richmond, VA 23298 (U.S.A.) SUMMARY The substances under review are a heterogenous set of compounds from a pharmacological point of view, though many have a common phenylethyl- amine structure. Variations in structure lead to marked changes in potency and characteristic action. The introductory material presented here is meant to provide a set of chemical and pharmacological highlights of the 28 substances under con- sideration. The most commonly used names or INN names, Chemical Abstract (CA) names and numbers, and elemental formulae are provided in the accompanying figures. This provides both some basic information on the substances and a starting point for the more detailed information that follows in the individual papers by contributors to the symposium. Key words: Stimulants, their chemistry and pharmacology - Hallucinogens, their chemistry and pharmacology INTRODUCTION Cathine (Fig. 1) is one of the active principles of khat (Catha edulis). The structure has two asymmetric centers and exists as two geometric isomers, each of which has been resolved into its optical isomers. In the plant it exists as d-nor-pseudoephedrine. It is a typical sympathomimetic amine with a strong component of amphetamine-like activity. The racemic mixture is known generically in this country and others as phenylpropanolamine (dl- norephedrine). It is widely available as an over-the-counter (OTC) anti- appetite agent and nasal decongestant.
    [Show full text]
  • The 2014 Prohibited List International Standard
    The World Anti-Doping Code THE 2014 PROHIBITED LIST INTERNATIONAL STANDARD Version 2.0 (revised 2014 version) The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the event of any conflict between the English and French versions, the English version shall prevail. This List shall come into effect on 1 September 2014 The revised 2014 Prohibited List 17 May 2014 THE 2014 PROHIBITED LIST WORLD ANTI-DOPING CODE Valid 1 September 2014 In accordance with Article 4.2.2 of the World Anti-Doping Code, all Prohibited Substances shall be considered as “Specified Substances” except Substances in classes S1, S2, S4.4, S4.5, S6.a, and Prohibited Methods M1, M2 and M3. SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OF-COMPETITION) PROHIBITED SUBSTANCES S0. NON-APPROVED SUBSTANCES Any pharmacological substance which is not addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited at all times. S1. ANABOLIC AGENTS Anabolic agents are prohibited. 1. Anabolic Androgenic Steroids (AAS) a. Exogenous* AAS, including: 1-androstenediol (5α-androst-1-ene-3β,17β-diol ); 1-androstenedione (5α- androst-1-ene-3,17-dione); bolandiol (estr-4-ene-3β,17β-diol ); bolasterone; boldenone; boldione (androsta-1,4-diene-3,17-dione); calusterone; clostebol;
    [Show full text]
  • (19) United States (12) Patent Application Publication (10) Pub
    US 20130289061A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0289061 A1 Bhide et al. (43) Pub. Date: Oct. 31, 2013 (54) METHODS AND COMPOSITIONS TO Publication Classi?cation PREVENT ADDICTION (51) Int. Cl. (71) Applicant: The General Hospital Corporation, A61K 31/485 (2006-01) Boston’ MA (Us) A61K 31/4458 (2006.01) (52) U.S. Cl. (72) Inventors: Pradeep G. Bhide; Peabody, MA (US); CPC """"" " A61K31/485 (201301); ‘4161223011? Jmm‘“ Zhu’ Ansm’ MA. (Us); USPC ......... .. 514/282; 514/317; 514/654; 514/618; Thomas J. Spencer; Carhsle; MA (US); 514/279 Joseph Biederman; Brookline; MA (Us) (57) ABSTRACT Disclosed herein is a method of reducing or preventing the development of aversion to a CNS stimulant in a subject (21) App1_ NO_; 13/924,815 comprising; administering a therapeutic amount of the neu rological stimulant and administering an antagonist of the kappa opioid receptor; to thereby reduce or prevent the devel - . opment of aversion to the CNS stimulant in the subject. Also (22) Flled' Jun‘ 24’ 2013 disclosed is a method of reducing or preventing the develop ment of addiction to a CNS stimulant in a subj ect; comprising; _ _ administering the CNS stimulant and administering a mu Related U‘s‘ Apphcatlon Data opioid receptor antagonist to thereby reduce or prevent the (63) Continuation of application NO 13/389,959, ?led on development of addiction to the CNS stimulant in the subject. Apt 27’ 2012’ ?led as application NO_ PCT/US2010/ Also disclosed are pharmaceutical compositions comprising 045486 on Aug' 13 2010' a central nervous system stimulant and an opioid receptor ’ antagonist.
    [Show full text]
  • UFC PROHIBITED LIST Effective June 1, 2021 the UFC PROHIBITED LIST
    UFC PROHIBITED LIST Effective June 1, 2021 THE UFC PROHIBITED LIST UFC PROHIBITED LIST Effective June 1, 2021 PART 1. Except as provided otherwise in PART 2 below, the UFC Prohibited List shall incorporate the most current Prohibited List published by WADA, as well as any WADA Technical Documents establishing decision limits or reporting levels, and, unless otherwise modified by the UFC Prohibited List or the UFC Anti-Doping Policy, Prohibited Substances, Prohibited Methods, Specified or Non-Specified Substances and Specified or Non-Specified Methods shall be as identified as such on the WADA Prohibited List or WADA Technical Documents. PART 2. Notwithstanding the WADA Prohibited List and any otherwise applicable WADA Technical Documents, the following modifications shall be in full force and effect: 1. Decision Concentration Levels. Adverse Analytical Findings reported at a concentration below the following Decision Concentration Levels shall be managed by USADA as Atypical Findings. • Cannabinoids: natural or synthetic delta-9-tetrahydrocannabinol (THC) or Cannabimimetics (e.g., “Spice,” JWH-018, JWH-073, HU-210): any level • Clomiphene: 0.1 ng/mL1 • Dehydrochloromethyltestosterone (DHCMT) long-term metabolite (M3): 0.1 ng/mL • Selective Androgen Receptor Modulators (SARMs): 0.1 ng/mL2 • GW-1516 (GW-501516) metabolites: 0.1 ng/mL • Epitrenbolone (Trenbolone metabolite): 0.2 ng/mL 2. SARMs/GW-1516: Adverse Analytical Findings reported at a concentration at or above the applicable Decision Concentration Level but under 1 ng/mL shall be managed by USADA as Specified Substances. 3. Higenamine: Higenamine shall be a Prohibited Substance under the UFC Anti-Doping Policy only In-Competition (and not Out-of- Competition).
    [Show full text]
  • Treatment of Self-Poisoned Adults G
    Archives of Emergency Medicine, 1985, 2, 203-208 Ipecacuanha induced emesis in the treatment of self-poisoned adults G. GORDON Accident and Emergency Department, Manor Hospital, Nuneaton, Warwickshire, England SUMMARY One hundred consecutive adult patients presenting to an Accident and Emergency Department following intentional self-poisoning were given 50 to 80 ml Paediatric Ipecacuanha Emetic Mixture BP as an emetic, together with two or three glasses of strong orange juice. A satisfactory emetic result was obtained in 99 patients. No toxic effects were noted in these patients, or in the one patient in whom emesis did not occur, and who subsequently refused gastric lavage. The potential toxicity of Ipecacuanha Syrup itself is discussed, and attention drawn to the lower Emetine content of Paediatric Ipecacuanha Emetic Mixture (BP), rather than that of the formulations used in previously published reports. The use of Paediatric Ipecacuanha Emetic Mixture B.P. in adults is effective and safe in this dosage. INTRODUCTION The methods available for retrieval of poisoning agents from the stomach are gastric lavage and emesis. In the United Kingdom at the present time, gastric lavage is the method most commonly used in the treatment of adults. It is an unpleasant and time consuming procedure for both patient and staff, and it is not without risk (Matthew et al., 1966), even in the hands of the experienced nursing staff who usually carry it out. Doubt still remains about its effectiveness (Goulding & Volans, 1977), and the basis for its use rests more on the occasional recovery of large quantities of drug, rather than verification of its routine efficiency by studies in man (Melman & Morelli, 1978).
    [Show full text]
  • Thyme, Celery and Salinomycin Implication on Antioxidant Capacity and Neurotransmitters Related to Milk Production in Pregnant Barki Ewes
    Advances in Applied Physiology 2021; 6(1): 23-29 http://www.sciencepublishinggroup.com/j/aap doi: 10.11648/j.aap.20210601.14 ISSN: 2471-9692 (Print); ISSN: 2471-9714 (Online) Thyme, Celery and Salinomycin Implication on Antioxidant Capacity and Neurotransmitters Related to Milk Production in Pregnant Barki Ewes Sherif Yousif Eid 1, *, Omar Abdel Hamid Ahmed-Farid 2, Hussein Mostafa El-Zaher 1, 1 Mahmoud Mohammed Shabaan 1Biological Applications Department, Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt 2Physiology Department, National Organization for Drug Control and Research (NODCAR), Cairo, Egypt Email address: *Corresponding author To cite this article: Sherif Yousif Eid, Omar Abdel Hamid Ahmed-Farid, Hussein Mostafa El-Zaher, Mahmoud Mohammed Shabaan. Thyme, Celery and Salinomycin Implication on Antioxidant Capacity and Neurotransmitters Related to Milk Production in Pregnant Barki Ewes. Advances in Applied Physiology. Vol. 6, No. 1, 2021, pp. 23-29. doi: 10.11648/j.aap.20210601.14 Received : May 7, 2021; Accepted : May 25, 2021; Published : May 31, 2021 Abstract: The experiment goal was the investigation of thyme (T), celery (C) and salinomycin effects on immune response, neurotransmitters related to milk production in Barki ewes. Total 72 mature ewes (2-3 years & 40±1.5 Kg BW) randomly pined equally into five groups. Group-1 was control; groups 2 & 3 received 20g/head/day T and C, respectively. Group-4 received 10g T+ 10g C/head/day, group-5 treated with salinomycin 1g/head/day. Samples collected during 2nd , 3rd trimester of pregnancy and on delivery day (DD); milk yield assessed on 15, 30 and 45-day postpartum.
    [Show full text]
  • Season with Herbs and Spices
    Season with Herbs and Spices Meat, Fish, Poultry, and Eggs ______________________________________________________________________________________________ Beef-Allspice,basil, bay leaf, cardamon, chives, curry, Chicken or Turkey-Allspice, basil, bay leaf, cardamon, garlic, mace, marjoram, dry mustard, nutmeg, onion, cumin, curry, garlic, mace, marjoram, mushrooms, dry oregano, paprika, parsley, pepper, green peppers, sage, mustard, paprika, parsley, pepper, pineapple sauce, savory, tarragon, thyme, turmeric. rosemary, sage, savory, tarragon, thyme, turmeric. Pork-Basil, cardamom, cloves, curry, dill, garlic, mace, Fish-Bay leaf, chives, coriander, curry, dill, garlic, lemon marjoram, dry mustard, oregano, onion, parsley, pepper, juice, mace, marjoram, mushrooms, dry mustard, onion, rosemary, sage, thyme, turmeric. oregano, paprika, parsley, pepper, green peppers, sage, savory, tarragon, thyme, turmeric. Lamb-Basil, curry, dill, garlic, mace, marjoram, mint, Eggs-Basil, chili powder, chives, cumin, curry, mace, onion, oregano, parsley, pepper, rosemary, thyme, marjoram, dry mustard, onion, paprika, parsley, pepper, turmeric. green peppers, rosemary, savory, tarragon, thyme. Veal-Basil, bay leaf, curry, dill, garlic, ginger, mace, marjoram, oregano, paprika, parsley, peaches, pepper, rosemary, sage, savory, tarragon, thyme, turmeric. Vegetables Asparagus-Caraway seed, dry mustard, nutmeg, sesame Broccoli-Oregano, tarragon. seed. Cabbage-Basil, caraway seed, cinnamon,dill, mace, dry Carrots-Chili powder, cinnamon, ginger, mace, marjoram, mustard,
    [Show full text]
  • The 2015 Prohibited List World Anti-Doping Code
    BGBl. III - Ausgegeben am 2. Dezember 2014 - Nr. 229 1 von 8 Appendix to letter JJ7878C of 21 November 2014 ANTI-DOPING CONVENTION (ETS No. 135) AMENDMENT TO THE APPENDIX approved by the Monitoring Group under Article 11.1.b of the Convention at its 41st meeting (Strasbourg, 5 November 2014) THE 2015 PROHIBITED LIST WORLD ANTI-DOPING CODE DATE OF ENTRY INTO FORCE : 1 JANUARY 2015 In accordance with Article 4.2.2 of the World Anti-Doping Code, all Prohibited Substances shall be considered as “Specified Substances” except Substances in classes S1, S2, S.4.4, S.4.5, S6.a, and Prohibited Methods M1, M2 and M3. SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OF-COMPETITION) PROHIBITED SUBSTANCES S0. NON-APPROVED SUBSTANCES Any pharmacological substance which is not addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited at all times. S1. ANABOLIC AGENTS Anabolic agents are prohibited. 1. Anabolic Androgenic Steroids (AAS) a. Exogenous* AAS, including: 1-androstenediol (5α-androst-1-ene-3β,17β-diol ); 1-androstenedione (5α-androst-1-ene-3,17-dione); bolandiol (estr-4-ene-3β,17β-diol ); bolasterone; boldenone; boldione (androsta-1,4-diene-3,17-dione); calusterone; clostebol; danazol ([1,2]oxazolo[4',5':2,3]pregna-4-en-20-yn-17α-ol); dehydrochlormethyltestosterone (4-chloro-17β-hydroxy-17α-methylandrosta-1,4-dien-3-one);
    [Show full text]
  • FEASTING THYME Serves Four, Available After 3Pm PROTEIN GARDEN SIDES Choose One Choose Two
    KIDS MENU DESSERT 12 and under Turkey and Cheese Sandwich Ice Cream Sandwich roasted turkey with side of fruit 3.99 Pastry Art’s lemon rosemary cookies with vanilla ice cream 3.49 AB&J Sandwich almond butter and homemade blueberry Cake Cups jam with seasonal fruit 3.99 Pastry Art’s daily selection 2.99 Spaghetti and Meatballs 4.99 Today’s Cheese Plate Grilled Chicken Dippers selection of three cheeses 9.99 served with choice of side 4.99 Flounder Cakes served with choice of side 4.99 DRINKS Simple Peas Fountain/Tea 1.99 Corn Polenta Bites Succotash with Herb Butter Orange Blossom Lemonade 2.49 + .99 refills Zucchini Salad Apples with Almond Butter Fresh Spa Water 2.99 Fresh Fruit Beer and wine served all day, cocktails served after 4pm. real food, good company FEASTING THYME serves four, available after 3pm PROTEIN GARDEN SIDES choose one choose two R&R Grilled Chicken 26.99 House Salad Spice Rubbed Chicken 26.99 Succotash with Herb Butter Corn Polenta Cake Roasted Turkey 26.99 Sweet and Spicy Slaw Flounder Cakes 29.99 Zucchini Salad Braised Beef 29.99 Humble Green Peas realandrosemary.com Charred Carrots with Thyme Spaghetti and Meatballs 25.99 Open daily from 11am to 9pm Located across from Pastry Art and the Aloft served with house salad and toast 1922 29th Ave S, Homewood, AL 35209 | 205-820-7100 SANDWICHES GARDEN SIDES served with one garden side 2.49 each Succotash with Herb Butter SNACKS Grilled Chicken grilled chicken, roasted portobello, Corn Polenta Cake collard pesto, charred red onion, Sweet and Spicy Slaw Collard Pesto Dip
    [Show full text]