Emerging Infectious Diseases
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Fighting Ebola: Voices from the Frontline Documenting the Experiences of East African Deployed Experts Who Volunteered to Fight Ebola in West Africa Implemented By
Fighting Ebola: Voices from the Frontline Documenting the experiences of East African deployed experts who volunteered to fight Ebola in West Africa Implemented by: Fighting Ebola: Voices from the Frontline Documenting the experiences of East African deployed experts who volunteered to fight Ebola in West Africa Contents Introduction . 6 Foreword from the Hon . Jesca Eriyo . 9 Foreword from Dr Zabulon Yoti . .. 10 Foreword from Dr Jackson Amone . 12 Foreword from Dr Irene Lukassowitz . 13 George Acire . 14 Rebecca Racheal Apolot . 17 Sarah Awilo . 22 Dr Mwaniki Collins . 24 Charles Draleku . 26 Emmanuel Ejoku .. 28 Dr Madina Hussein . 31 Loveness Daniel Isojick . 34 Dr Abdulrahman Said Kassim . 36 Teddy Kusemererwa . .. 40 Liliane Luwaga . 43 Dr Appolinaire Manirafasha . 46 Dr Landry Mayigane . 48 James Mugume . 50 Dr Monica Musenero . 52 Doreen Nabawanuka . 55 Dr Bella Nihorimbere . 56 Teresia Wairimu Thuku . 57 Tony Walter Onena . 59 Acknowledgements . 61 4 Fighting Ebola: Voices from the Frontline 5 Introduction ccording to the World Health Organization (WHO), Others, seeing scenes of death and devastation on their The East African Community Secretariat, in collaboration the Ebola epidemic that occurred in West Africa television screens, just felt compelled to do whatever they with the Federal Government of Germany through the Abetween 2014 and 2016 killed over 11,000 people could to help . Given that so many West African health GIZ-coordinated Support to Pandemic Preparedness in out of the almost 30,000 that were infected . From one -
Determination of the Effects That a Previously Uncharacterized Secreted Product from Klebsiella Pneumoniae Has on Citrobacter Fr
East Tennessee State University Digital Commons @ East Tennessee State University Undergraduate Honors Theses Student Works 5-2017 Determination of the effects that a previously uncharacterized secreted product from Klebsiella pneumoniae has on Citrobacter freundii and Enterobacter cloacae biofilms Cody M. Hastings Follow this and additional works at: https://dc.etsu.edu/honors Part of the Bacteria Commons, Bacteriology Commons, Biological Phenomena, Cell Phenomena, and Immunity Commons, Cell and Developmental Biology Commons, Medical Cell Biology Commons, Medical Microbiology Commons, Microbial Physiology Commons, and the Pathogenic Microbiology Commons Recommended Citation Hastings, Cody M., "Determination of the effects that a previously uncharacterized secreted product from Klebsiella pneumoniae has on Citrobacter freundii and Enterobacter cloacae biofilms" (2017). Undergraduate Honors Theses. Paper 419. https://dc.etsu.edu/ honors/419 This Honors Thesis - Withheld is brought to you for free and open access by the Student Works at Digital Commons @ East Tennessee State University. It has been accepted for inclusion in Undergraduate Honors Theses by an authorized administrator of Digital Commons @ East Tennessee State University. For more information, please contact [email protected]. Determination of the effects that a previously uncharacterized secreted product from Klebsiella pneumoniae has on Citrobacter freundii and Enterobacter cloacae biofilms By Cody Hastings An Undergraduate Thesis Submitted in Partial Fulfillment of the Requirements -
Targeting Ebola 2015
Agenda of Targeting Ebola 2015 May 28-29, 2015 Institut Pasteur - Paris, France www.targeting-ebola.com Welcome Note On behalf of the Targeting Infectious Diseases Committee, the Institut Pasteur, the COPED and the Task Force for Ebola in France, it is our pleasure to announce the organization of the International Congress on Targeting Ebola 2015 which will be held on May 28-29, 2015 at Pasteur Institute, Paris, France. The World Health Organization (WHO) was notified on March 23, 2014, of an outbreak of EVD in Guinea. The disease soon spread to the bordering countries of Liberia and Sierra Leone, which are the most severely affected countries. On August 8, 2014, the epidemic was declared a “public health emergency of international concern” (WHO Ebola Response Team, NEJM 2014, 371, 1481). Suspected cases of EVD have since been reported in seven affected countries (Guinea, Liberia, Nigeria, Senegal, Sierra Leone, Spain, and the United States of America). Unprecedented in scale and geographical distribution since the identification of Ebola in 1976, the current epidemic has an apparent overall case-fatality ratio of about 70%; but it is suspected that many more cases have gone unrecorded. On May 2015, more than 10.000 deaths and 30.000 cases had been reported in Sierra Leone, Liberia and Guinea, according to the WHO. Globally, the situation is improving. The epidemic is over in Liberia, however in Guinea and Sierra Leone, the initial decline observed a few weeks ago is stable with approximately 20 new cases / week. The vast majority of cases are reported from the western prefecture of Forecariah, which borders the Sierra Leonean district of Kambia. -
Clinical Trial Protocol Sponsored by OCRPRO
PREVAIL IV: Double-blind, Randomized, Two-phase, Placebo-controlled, Phase II Trial of GS-5734 to Assess the Antiviral Activity, Longer-term Clearance of Ebola Virus, and Safety in Male Ebola Survivors with Evidence of Ebola Virus Persistence in Semen NIAID Protocol Number: 16-I-N137 Version Number: 10.0 Date: May 13, 2019 Investigational New Drug (IND) Number: 130621 IND Sponsor: Office of Clinical Research Policy and Regulatory Operations (OCRPRO), Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) Local Liberian Medical Officer: Ian Wachekwa, MD Safety Medical Officer John F. Kennedy Hospital 21 Street, Sinkor Monrovia, Liberia [email protected] (t) +231880890907 Sponsor Medical Monitor: Alan Lifson, MD, MPH Professor, Division of Epidemiology and Community Health School of Public Health University of Minnesota 1300 S. Second St., Ste. 300 Minneapolis, MN 55454 (t) 612-626-9697 (f) 612-624-0315 [email protected] Pharmaceutical Support Provided by: Gilead Sciences, Inc. PREVAIL IV Version 10.0 13 May 2019 Conducted by: Liberia-US Joint Clinical Research Partnership also known as the Partnership for Research on Ebola Virus in Liberia (PREVAIL) Page 2 of 77 PREVAIL IV Version 10.0 13 May 2019 Key Roles NIH Principal Investigator: Elizabeth S. Higgs, MD, MIA, DTMH Division of Clinical Research, NIAID [email protected] (c) +301-768-3947 skype: libby.higgs2 Liberian Principal Investigator: Dehkontee Gayedyu-Dennis, MD PREVAIL [email protected] (t) +231-886-538-810 -
Chapter 1 BEFORE EBOLA
10/12/2017 Preparing for a Crisis: Lessons Learned at Emory Before, During, and After Ebola Jay B. Varkey, MD On behalf of the Chapter 1 BEFORE EBOLA 2 1 10/12/2017 The Story of Emile Meliandou, Guinea, December 2013 Photograph by Suzanne Beukes, UNICEF The Story of Emile Meliandou, Guinea, December 2013 AM Saéz et al, EMBO Mole Med 2015 2 10/12/2017 The Story of Emile Meliandou, Guinea, December 2013 The Story of Emile Meliandou, Guinea, December 2013 AM Saéz et al, EMBO Mole Med 2015 3 10/12/2017 The Story of Emile Meliandou, Guinea, December 2013 Photograph by Suzanne Beukes, UNICEF Spread of a “Cholera‐Like Illness” MeliandouConakry, 12/2013 – 3/2014 S Baize, N Engl J Med 2014 4 10/12/2017 Ebola Virus Disease (EVD) Spread to Liberia and Sierra Leone 4/2014 ELWA Ebola Treatment Unit (ETU) Monrovia, Liberia 6/2014 – 7/2014 Photograph by Bethany Fankhauser, SIM 5 10/12/2017 ELWA ETU Monrovia, Liberia 6/2014 – 7/2014 Photograph by Bethany Fankhauser, SIM ELWA ETU Monrovia, Liberia July 2014 • 40 patients with EVD treated • 39 of 40 died • July 22‐23: 2 American humanitarians working in the ELWA ETC develop a fever…. • Initially treated for malaria • Laboratory testing confirmed Ebola Virus Disease 6 10/12/2017 Ebola Virus Disease and Emory July 30, 2014 • Emory University Hospital was asked to receive the first patients with confirmed Ebola virus disease to be treated in the United States • 2 American humanitarians had become infected while working in an ETU in Monrovia, Liberia • Patient 1: 33 yo male physician • Patient 2: 59 yo female medical missionary • Expected arrival time unclear but Emory was asked to be ready to receive the 1st patient within 72 hours. -
Kinase Inhibitors and Nucleoside Analogues As Novel Therapies to Inhibit HIV-1 Or ZEBOV Replication
Kinase Inhibitors and Nucleoside Analogues as Novel Therapies to Inhibit HIV-1 or ZEBOV Replication by Stephen D. S. McCarthy A thesis submitted in conformity with the requirements for the degree of Doctor of Philosophy Department of Laboratory Medicine and Pathobiology University of Toronto © Copyright by Stephen D. S. McCarthy (2017) Kinase Inhibitors and Nucleoside Analogues as Novel Therapies to Inhibit HIV-1 or ZEBOV Replication Stephen D.S. McCarthy Doctor of Philosophy Graduate Department of Laboratory Medicine and Pathobiology University of Toronto 2017 Abstract Without a vaccine for Human Immunodeficiency Virus type 1 (HIV-1), or approved therapy for treating Zaire Ebolavirus (ZEBOV) infection, new means to treat either virus during acute infection are under intense investigation. Repurposing tyrosine kinase inhibitors of known specificity may not only inhibit HIV-1 replication, but also treat associated inflammation or neurocognitive disorders caused by chronic HIV-1 infection. Moreover, tyrosine kinase inhibitors may effectively treat other infections, including ZEBOV. In addition, established nucleoside/nucleotide analogues that effectively inhibit HIV-1 infection, could also be repurposed to inhibit ZEBOV replication. In this work the role of two host cell kinases, cellular protoncogene SRC (c-SRC) and Protein Tyrosine Kinase 2 Beta (PTK2B), were found to have key roles during early HIV-1 replication in primary activated CD4+ T-cells ex vivo. siRNA knockdown of either kinase increased intracellular reverse transcripts and decreased nuclear proviral integration, suggesting they act at the level of pre-integration complex (PIC) formation or PIC nuclear translocation. c-SRC siRNA knockdown consistently reduced p24 levels of IIIB(X4) and Ba-L(R5) infection, or luciferase ii activity of HXB2(X4) or JR-FL(R5) recombinant viruses, prompting further drug inhibition studies of this kinase. -
Ohio Department of Health, Bureau of Infectious Diseases Disease Name Class A, Requires Immediate Phone Call to Local Health
Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change) Culture independent diagnostic tests' (CIDT), like BioFire panel or BD MAX, E. histolytica Stain specimen = stool, bile results should be sent as E. histolytica DNA fluid, duodenal fluid, 260373001^DETECTED^SCT with E. histolytica Antigen Amebiasis (Entamoeba histolytica) No No tissue large intestine, disease/organism-specific DNA LOINC E. histolytica Antibody tissue small intestine codes OR a generic CIDT-LOINC code E. histolytica IgM with organism-specific DNA SNOMED E. histolytica IgG codes E. histolytica Total Antibody Ova and Parasite Anthrax Antibody Anthrax Antigen Anthrax EITB Acute Anthrax EITB Convalescent Anthrax Yes No Culture ELISA PCR Stain/microscopy Stain/spore ID Eastern Equine Encephalitis virus Antibody Eastern Equine Encephalitis virus IgG Antibody Eastern Equine Encephalitis virus IgM Arboviral neuroinvasive and non- Eastern Equine Encephalitis virus RNA neuroinvasive disease: Eastern equine California serogroup virus Antibody encephalitis virus disease; LaCrosse Equivocal results are accepted for all California serogroup virus IgG Antibody virus disease (other California arborviral diseases; California serogroup virus IgM Antibody specimen = blood, serum, serogroup -
Ann Powers YOU BETTER THINK
Ann Powers YOU BETTER THINK: Why Feminist Cultural Criticism Still Matters in a "Post-Feminist," Peer-to-Peer World Tenth Annual USC Women in Higher Education Luncheon Sponsored by the Gender Studies Program and Center for Feminist Research at USC University of Southern California March 10, 2009 2 THE NORMAN LEAR CENTER Ann Powers: YOU BETTER THINK YOU BETTER THINK: Why Feminist Cultural Criticism Still Matters in a "Post-Feminist," Peer-to-Peer World Gender Studies Program . The Norman Lear Center Gender Studies at USC is an interdisciplinary program composed Founded in January 2000, the Norman Center for Feminist Research of faculty, students, and associated Lear Center is a multidisciplinary scholars who work together to research and public policy center For 20 years, CFR has worked, examine the world through the lens exploring implications of the together with the USC Gender Studies of gender. We cross cultures, regions, convergence of entertainment, Program, to provide the University of periods, academic disciplines, and commerce and society. On campus, Southern California's feminist theories in order to study: from its base in the USC Annenberg community with research the meaning of "male" and "female" School for Communication, the Lear opportunities for the study of women, as well as the actions of women and Center builds bridges between schools gender, and feminis. A variety of men. and disciplines whose faculty study seminars, workshops, conferences, social roles and sexual identities in aspects of entertainment, media and and informal gatherings have brought the contexts of race, class, and culture. Beyond campus, it bridges the together a network of faculty, ethnicity. -
5 Letter from the Editors
BURNmagazine Issue 5 Letter from the Editors What is Burn? As new editors resurrecting Burn Magazine from its last publication in 2010, we look to embody our preceding editors’ hopes for Burn, despite moving into the future; that is, compiling a literary magazine that allows its readers to momentarily escape their busy collegiate lives in Boston and immerse themselves in the words, thoughts, and images of their undergraduate colleagues. We chose the following pieces based on both on their unique concepts and varying styles, though we decided against a specific theme for this issue to bind the contributions together aside from the fact that they all were written by undergraduates. Our hope is that because of the wide range of pieces we chose, Burn will appeal to all types of people at Boston University as a way to experience the creativity of those who may be outside of their discipline’s realm—we want this magazine and its contributors’ voices to reach people outside of just family and friends (though we do appreciate these you). We hope you enjoy the pieces we selected from our submissions this semester, and we look forward to the future of Burn Magazine. Best, Jenna Bessemer and Tori Sommerman, Co-Editors Zachary Bos, Advising Editor Founded in 2006 by Catherine Craft, Mary Sullivan, and Chase Quinn. Boston University undergraduates may send submissions to [email protected]. Manuscripts are considered year-round. Burn Magazine is published according to an irregular schedule by the Boston University Literary Society; printed by the Pen & Anvil Press. Front cover photograph by Tori Sommerman, COM 2013. -
Use of the Diagnostic Bacteriology Laboratory: a Practical Review for the Clinician
148 Postgrad Med J 2001;77:148–156 REVIEWS Postgrad Med J: first published as 10.1136/pmj.77.905.148 on 1 March 2001. Downloaded from Use of the diagnostic bacteriology laboratory: a practical review for the clinician W J Steinbach, A K Shetty Lucile Salter Packard Children’s Hospital at EVective utilisation and understanding of the Stanford, Stanford Box 1: Gram stain technique University School of clinical bacteriology laboratory can greatly aid Medicine, 725 Welch in the diagnosis of infectious diseases. Al- (1) Air dry specimen and fix with Road, Palo Alto, though described more than a century ago, the methanol or heat. California, USA 94304, Gram stain remains the most frequently used (2) Add crystal violet stain. USA rapid diagnostic test, and in conjunction with W J Steinbach various biochemical tests is the cornerstone of (3) Rinse with water to wash unbound A K Shetty the clinical laboratory. First described by Dan- dye, add mordant (for example, iodine: 12 potassium iodide). Correspondence to: ish pathologist Christian Gram in 1884 and Dr Steinbach later slightly modified, the Gram stain easily (4) After waiting 30–60 seconds, rinse with [email protected] divides bacteria into two groups, Gram positive water. Submitted 27 March 2000 and Gram negative, on the basis of their cell (5) Add decolorising solvent (ethanol or Accepted 5 June 2000 wall and cell membrane permeability to acetone) to remove unbound dye. Growth on artificial medium Obligate intracellular (6) Counterstain with safranin. Chlamydia Legionella Gram positive bacteria stain blue Coxiella Ehrlichia Rickettsia (retained crystal violet). -
Department of Music Stony Brook University
Department of Music Stony Brook University The Revolution guitarist Wendy Melvoin Department of Music Stony Brook University Rock, pop music, and society MUS 109 (86275) Fall 2018 This course is a (mostly) chronological survey of the musicians, producers, albums, concerts, genres, instruments, publications, substances, sounds, arguments, and ideas crucial to the past seven decades of rock and pop music. We will examine a musical form vital to twentieth-century artistic innovation, grappling with questions of race, gender, sexuality, and political change along the way. In addition to readings, you will listen carefully to important pieces of music, exploring them formally and historically. Each week, you’ll read a mixture of autobiography, music journalism, interviews, social criticism, and more. You will listen to music, and sometimes view a documentary or video. Several short response essays throughout the semester will allow you to flex your critical and argumentative muscles. By the end of the semester, you will possess an expanded musical vocabulary and a deep knowledge of an important branch of musical history. Class meetings: Tuesday and Thursday, 10:00 a.m.-11:20 p.m. Location: Frey, Room 100 Professor: Dr. Benjamin Tausig ([email protected]) Teaching assistants: Sarah Ghandour ([email protected]) Rebecca Lentjes ([email protected]) Stephen Moran ([email protected]) Kathryn Vetter ([email protected]) Office hours Professor - Tuesday, 11:30-12:30 a.m., or Wednesday by -
405, Dept. of African American Stds, 81 Wall Street
Prof. D. A. Brooks [email protected] Office: 405, Dept. of African American Stds, 81 Wall Street Spring 2015 Meets Tu/Th 2:30-3:45pm Location: WLH 208 Office Hours: Tu: 4-5pm, W: 3:30pm-5pm & by appointment AFAM 403/THST 431/AM STDS 386 “…Who Run the World”: Black Women and Popular Music Culture [Billie] Holiday demonstrates… the value of important lives and voices Otherwise dismissed. --Lindon Barrett, Blackness and Value My persuasion can build a nation. --Beyonce From Bessie Smith and Billie Holiday to Tina Turner and Beyonce, from Nina Simone and Grace Jones to Lauryn Hill and Nicki Minaj, black women have used various forms of musical expression as sites of social and ideological resistance and revision. Through an exploration of voice, lyricism, kinesthetic performance, instrumentality and visual aesthetics, this course examines the “world wide underground” of black women’s sonic cultures, and it re-interrogates pop music subculture theories through the intersecting prisms of race, gender, class and sexuality. It considers the ways that black women musicians operate as socio- political and cultural intellectuals, and it reads their work as historically-situated cultural texts that resonate in multiple contexts. Throughout the semester, we will explore the ways in which black women culture workers have stylized and innovated disruptive and iconic performance practices within the context of American popular music culture, from the postbellum era through the present day. Part of the aim of this course is to trace the tensions between the enormous influence and ubiquity of the black female singing voice in globalized popular cultures and the ways in which a range of entertainers have nonetheless negotiated eccentric and “obscure” musical gestures that signaled and affirmed the existence of resistant musical aesthetics in the face of panopticism.