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Toxines Et Fonctions Cholinergiques Neuronales Et Non Neuronales

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Collection Rencontres en toxinologie © P. Marchot & J.-L. Boudier TTooxxiinneess eett ffoonnccttiioonnss cchhoolliinneerrggiiqquueess nneeuurroonnaalleess eett nnoonn nneeuurroonnaalleess Comité d’édition : Evelyne BENOIT, Françoise GOUDEY-PERRIERE, Pascale MARCHOT et Denis SERVENT Société Française pour l'Etude des Toxines Illustrations de couverture : En haut : Vue en microscopie électronique des synapses neuromusculaires du muscle triangulaire de sternum de souris (grossissement de 13 333 fois). Les pelotes noires sont générées par des molécules d’alpha-neurotoxine « à trois doigts », isolée d’un venin de cobra et radioiodée, fixées aux récepteurs nicotiniques de l’acétylcholine associés aux membranes post-synaptiques. (Copyright Pascale Marchot et Jean-Louis Boudier) En bas : Vue cristallographique du complexe de haute affinité formé entre (en jaune) cinq exemplaires d’une alpha- neurotoxine « à trois doigts », isolée d’un venin de cobra, et (en bleu) l’acetylcholine binding protein, protéine homopentamérique de mollusque aquatique et équivalent soluble du domaine extracellulaire de fixation des ligands du récepteur nicotinique de l’acétylcholine. (Copyright Pascale Marchot et Yves Bourne) Près de vingt ans de travaux menés par de nombreuses équipes au plan international relient ces deux images. Collection Rencontres en toxinologie La collection « Rencontres en toxinologie » est publiée à l’occasion des Colloques annuels « Rencontres en toxinologie » organisés par la Société Française pour l’Etude des Toxines (SFET). Les ouvrages parus de 2001 à 2007 ont été édités par Elsevier (Paris, France), puis par la Librairie Lavoisier (Cachan, France). A partir de 2008, ils seront édités par la SFET et diffusés sur le site http://www.sfet.asso.fr, en libre accès pour les auteurs et les lecteurs. Titres parus Explorer, exploiter les toxines et maîtriser les organismes producteurs Cassian Bon, Françoise Goudey-Perrière, Bernard Poulain, Simone Puiseux-Dao Elsevier, Paris, 2001 ISBN : 2-84299-359-4 Toxines et recherches biomédicales Françoise Goudey-Perrière, Cassian Bon, Simone Puiseux-Dao, Martin-Pierre Sauviat Elsevier, Paris, 2002 ISBN : 2-84299-445-0 Toxinogenèse – Biosynthèse, ingénierie, polymorphisme et neutralisation des toxines Françoise Goudey-Perrière, Cassian Bon, André Ménez, Simone Puiseux-Dao Elsevier, Paris, 2003 ISBN : 2-84299-481-7 Envenimations, intoxinations Françoise Goudey-Perrière, Evelyne Benoit, Simone Puiseux-Dao, Cassian Bon Librairie Lavoisier, Cachan, 2004 ISBN : 2-7430-0749-4 Toxines et douleur Cassian Bon, Françoise Goudey-Perrière, Max Goyffon, Martin-Pierre Sauviat Librairie Lavoisier, Cachan, 2005 ISBN : 2-7430-0849-0 Toxines et cancer Françoise Goudey-Perrière, Evelyne Benoit, Max Goyffon, Pascale Marchot Librairie Lavoisier, Cachan, 2006 ISBN : 2-7430-0958-6 Toxines émergentes : nouveaux risques Françoise Goudey-Perrière, Evelyne Benoit, Pascale Marchot, Michel R. Popoff Librairie Lavoisier, Cachan, 2007 ISBN : 978-2-7430-1037-9 Cet ouvrage est publié à l’occasion du colloque « 16èmes Rencontres en toxinologie », organisé par la Société Française pour l’Etude des Toxines (SFET) les 20 et 21 novembre 2008 à Paris. Le comité d’organisation est constitué de : Evelyne Benoit, Françoise Goudey-Perrière, Max Goyffon, Pascale Marchot et Denis Servent. Le comité scientifique est constitué de : Joseph Alouf, Evelyne Benoit, Blandine Gény, Françoise Goudey-Perrière, Max Goyffon, Françoise Grolleau, Pascale Marchot, Jordi Molgó, Michel R. Popoff, Bernard Poulain, Simone Puiseux-Dao et Denis Servent. Le comité de rédaction est constitué de : Evelyne Benoit, Philippe Billiald, Pierre Bougis, Patrick Breton, Jean-Philippe Chippaux , Pierre-Jean Corringer, Jean- Marc Dubois, Grazyna Faure, Philippe Fossier, Robert Frangez, Blandine Gény, Françoise Goudey-Perrière, Max Goyffon, Luc de Haro, Pascale Marchot, Marie-France Martin-Eauclaire, Dietrich Mebs, Jordi Molgó, Nicole Pagès, Michel R. Popoff, Simone Puiseux-Dao, Jean-Pierre Rosso, Catherine Rougeot, Denis Servent et Annick Simon. Sommaire Pages Cassian BON, 1944 - 2008 9-10 Max Goyffon André MENEZ, 1943 - 2008 11-12 Max Goyffon Toxines et fonctions cholinergiques Les spirolides : une famille de toxines émergentes qui contaminent les mollusques 13-17 bivalves Riadh MARROUCHI, Sébastien SCHLUMBERGER, Evelyne BENOIT, Romulo ARAOZ, Riadh KHARRAT, Jordi MOLGO Cnidarian toxins acting on the cholinergic system 19-22 Klara BULC ROZMAN, Dušan ŠUPUT, Jordi MOLGO, Evelyne BENOIT Fluorescent cholinergic agonists for functional studies of nicotinic receptor 23-26 Elias SAKR, Sébastien CHARON, Florian KRIEGER, Jordi RODRIGO, Maurice GOELDNER Utilisation des « protéines liant l'acétylcholine » (AChBP) en toxinologie structurale : 27-28 nouveaux exemples Yves BOURNE, Zoran RADIC, Todd. T. TALLEY, Sandrine CONROD, Palmer TAYLOR, Jordi MOLGO, Pascale MARCHOT Retrogenomics - Proceeding from gene product back to the gene : applications in drug 29-32 discovery and uncovering linkages in congenital disorders Palmer TAYLOR, Zoran RADIC, Todd T. TALLEY, Akos NEMECZ, Antonella DE JACO, Davide COMOLETTI, Igor P. FABRICHNY, Philippe LEONE, Meghan T. MILLER, Noga DUBI, Valery V. FOKIN, K. Barry SHARPLESS, Yves BOURNE, Pascale MARCHOT Venom peptides from Conus and other Conoideans : prospects and perspectives 33-42 Baldomero M. OLIVERA Alpha-conotoxines, outils pour l’étude pharmacologique et structurale des récepteurs 43-46 nicotiniques neuronaux Sébastien DUTERTRE, Daniel BIASS, Philippe FAVREAU, Sophie MICHALET, Reto STÖCKLIN Novel roles of highly specific natural inhibitors of the angiotensin-converting enzyme 47-54 Mirian A.F. HAYASHI, Arthur Andrade NERY, Antonio C.M. CAMARGO, Henning ULRICH Toxines et identification des sous-types de récepteurs nicotiniques neuronaux d’insectes 55-61 Béatrice BODEREAU, Hélène TRICOIRE-LEIGNEL, Bruno LAPIED, Steeve H. THANY Neuronal cholinergic toxins : possible drugs for lung cancer treatment 63-67 Patrizia RUSSO, Laura PALEARI, Alessia CATASSI, Carole FRUCHART-GAILLARD, Gilles MOURIER, Denis SERVENT Activité agoniste cholinergique induite par la fraction non toxique du venin de Buthus 69-74 occitanus tunetanus Amani CHEIKH, Rym BENKHALIFA, Daniel POTREAU, Jocelyn BESCOND, Mohamed EL AYEB, Guy RAYMOND, Christian COGNARD Les toxines à trois doigts : même structure, même mécanisme de repliement ? 75-78 Grégori GROSS, Pascal DREVET La toxine MT7 : un outil de choix dans l’étude pharmacologique du récepteur 79-85 muscarinique M1 Carole FRUCHART-GAILLARD, Gilles MOURIER, Denis SERVENT Case report of the use of Datura stramonium for recreational purpose 87-88 Ruta LEKSIENE, Jonas SURKUS, Algirdas STONYS L'acétylcholinestérase et les venins de serpents 89-92 Jean MASSOULIE Utilisation de la fasciculine-2, une toxine de venin de serpent, pour étudier 93-100 l’acétylcholinestérase in vivo : avantages et inconvénients Véronique BERNARD, Eric KREJCI Pages Toxines et autres fonctions Nouvelles observations appuyant le rôle de la toxine STb d’Escherichia coli dans la 101-104 diarrhée chez l’Homme Marie-Astrid ALBERT, J. Daniel DUBREUIL Présence d’un variant de la toxine STb d’Escherichia coli chez certains porcs malades 105-106 Christine TAILLON, Éric NADEAU, Michaël MOUREZ, J. Daniel DUBREUIL Le domaine T de la toxine diphtérique favorise la liaison et la pénétration membranaire du 107-110 domaine catalytique Anne CHASSAING, Sylvain PICHARD, Vincent FORGE, Daniel GILLET Phytotherapy and adverse reactions 111-118 Nubilde MARTÍNEZ, Edmundo CAYAMA, Nubi LEÓN, Lisbeth PÉREZ Profil des accidents par des animaux venimeux au Brésil, 2001 à 2006 119-122 Rosany BOCHNER, Judith Tiomny FISZON Les toxines des venins des scorpions du genre Androctonus 123-127 Najwa ABBAS, Jean-Pierre ROSSO, Maya BELGHAZI, Brigitte CEARD, Pierre-Edouard BOUGIS, Marie-France MARTIN-EAUCLAIRE Incidence de la fraction toxique du venin d’Androctonus australis hector dans la 129-130 leucocytose pulmonaire Sassia SAMI-MERAH, Djelila HAMMOUDI-TRIKI, Djamila AROUNE, Marie-France MARTIN-EAUCLAIRE, Fatima LARABA-DJEBARI Immunoglobulines F(ab’)2 produites contre la fraction toxique du venin du scorpion 131-134 marocain (Androctonus mauretanicus mauretanicus) Naoual OUKKACHE, Mohamed HASSAR, Abdelaziz KAROUMI, Fatima CHGOURY, Lotfi BOUSSADDA, Rachid SAILE, Marie-France MARTIN-EAUCLAIRE, Noreddine GHALIM Reprotoxicité des venins d’invertébrés 135-141 Françoise GOUDEY-PERRIERE, Nicole PAGES, Claude PERRIERE Reprotoxicité des venins de Vertébrés 143-150 Nicole PAGES, Françoise GOUDEY-PERRIERE, Claude PERRIERE Action of the Crotalus durissus cascavella venom on arterial blood pressure 151-152 Janaina S.A.M. EVANGELISTA, Alice M.C. MARTINS, João J.F. EVANGELISTA, Nilberto F. NASCIMENTO, Antoniela S. GOMES, Glaycianne B. de MORAIS, João A. M. SILVEIRA, Paula P.C. COSTA, Marcellus H.L.P. de SOUZA, Diva M. BORGES-NOJOSA, Dalgimar B. de MENEZES, Maria Elisabete A. MORAES, Helena S. A. MONTEIRO Caractérisation d’une fraction coagulante isolée du venin de Cerastes cerastes 153-154 Fatah CHERIFI, Fatima LARABA-DJEBARI Caractéristiques structurales et fonctionnelles de deux b-neurotoxines : l’ammodytoxine et 155-160 la crotoxine Grazyna FAURE, Frederick SAUL Cet ouvrage est dédié à la mémoire de Cassian Bon, décédé le 20 mars 2008 et André Ménez, décédé le 2 février 2008 Toxines et fonctions cholinergiques neuronales et non neuronales 9 Rencontres en toxinologie, 2008 Editions de la SFET Accès libre en ligne sur le site http://www.sfet.asso.fr, avec autorisation des auteurs Cassian BON, 1944 – 2008 Cassian
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  • 1: Gastro-Intestinal System

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  • Venom Week 2012 4Th International Scientific Symposium on All Things Venomous

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    17th World Congress of the International Society on Toxinology Animal, Plant and Microbial Toxins & Venom Week 2012 4th International Scientific Symposium on All Things Venomous Honolulu, Hawaii, USA, July 8 – 13, 2012 1 Table of Contents Section Page Introduction 01 Scientific Organizing Committee 02 Local Organizing Committee / Sponsors / Co-Chairs 02 Welcome Messages 04 Governor’s Proclamation 08 Meeting Program 10 Sunday 13 Monday 15 Tuesday 20 Wednesday 26 Thursday 30 Friday 36 Poster Session I 41 Poster Session II 47 Supplemental program material 54 Additional Abstracts (#298 – #344) 61 International Society on Thrombosis & Haemostasis 99 2 Introduction Welcome to the 17th World Congress of the International Society on Toxinology (IST), held jointly with Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, in Honolulu, Hawaii, USA, July 8 – 13, 2012. This is a supplement to the special issue of Toxicon. It contains the abstracts that were submitted too late for inclusion there, as well as a complete program agenda of the meeting, as well as other materials. At the time of this printing, we had 344 scientific abstracts scheduled for presentation and over 300 attendees from all over the planet. The World Congress of IST is held every three years, most recently in Recife, Brazil in March 2009. The IST World Congress is the primary international meeting bringing together scientists and physicians from around the world to discuss the most recent advances in the structure and function of natural toxins occurring in venomous animals, plants, or microorganisms, in medical, public health, and policy approaches to prevent or treat envenomations, and in the development of new toxin-derived drugs.
  • Rope Parasite” the Rope Parasite Parasites: Nearly Every Au�S�C Child I Ever Treated Proved to Carry a Significant Parasite Burden

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    Au#sm: 2015 Dietrich Klinghardt MD, PhD Infec4ons and Infestaons Chronic Infecons, Infesta#ons and ASD Infec4ons affect us in 3 ways: 1. Immune reac,on against the microbes or their metabolic products Treatment: low dose immunotherapy (LDI, LDA, EPD) 2. Effects of their secreted endo- and exotoxins and metabolic waste Treatment: colon hydrotherapy, sauna, intes4nal binders (Enterosgel, MicroSilica, chlorella, zeolite), detoxificaon with herbs and medical drugs, ac4vaon of detox pathways by solving underlying blocKages (methylaon, etc.) 3. Compe,,on for our micronutrients Treatment: decrease microbial load, consider vitamin/mineral protocol Lyme, Toxins and Epigene#cs • In 2000 I examined 10 au4s4c children with no Known history of Lyme disease (age 3-10), with the IgeneX Western Blot test – aer successful treatment. 5 children were IgM posi4ve, 3 children IgG, 2 children were negave. That is 80% of the children had clinical Lyme disease, none the history of a 4cK bite! • Why is it taking so long for au4sm-literate prac44oners to embrace the fact, that many au4s4c children have contracted Lyme or several co-infec4ons in the womb from an oVen asymptomac mother? Why not become Lyme literate also? • Infec4ons can be treated without the use of an4bio4cs, using liposomal ozonated essen4al oils, herbs, ozone, Rife devices, PEMF, colloidal silver, regular s.c injecons of artesunate, the Klinghardt co-infec4on cocKtail and more. • Symptomac infec4ons and infestaons are almost always the result of a high body burden of glyphosate, mercury and aluminum - against the bacKdrop of epigene4c injuries (epimutaons) suffered in the womb or from our ancestors( trauma, vaccine adjuvants, worK place related lead, aluminum, herbicides etc., electromagne4c radiaon exposures etc.) • Most symptoms are caused by a confused upregulated immune system (molecular mimicry) Toxins from a toxic environment enter our system through damaged boundaries and membranes (gut barrier, blood brain barrier, damaged endothelium, etc.).