International Journal of Molecular Sciences Review Human Radiosensitivity and Radiosusceptibility: What Are the Differences? Laura El-Nachef 1, Joelle Al-Choboq 1, Juliette Restier-Verlet 1, Adeline Granzotto 1, Elise Berthel 1,2, Laurène Sonzogni 1,Mélanie L. Ferlazzo 1, Audrey Bouchet 1 , Pierre Leblond 3, Patrick Combemale 3, Stéphane Pinson 4, Michel Bourguignon 1,5 and Nicolas Foray 1,* 1 Inserm, U1296 unit, Radiation: Defense, Health and Environment, Centre Léon-Bérard, 28, rue Laennec, 69008 Lyon, France;
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[email protected]; Tel.: +33-4-78-78-28-28 Abstract: The individual response to ionizing radiation (IR) raises a number of medical, scientific, and societal issues. While the term “radiosensitivity” was used by the pioneers at the beginning Citation: El-Nachef, L.; Al-Choboq, of the 20st century to describe only the radiation-induced adverse tissue reactions related to cell J.; Restier-Verlet, J.; Granzotto, A.; death, a confusion emerged in the literature from the 1930s, as “radiosensitivity” was indifferently Berthel, E.; Sonzogni, L.; Ferlazzo, used to describe the toxic, cancerous, or aging effect of IR.