Alumni Directory 1992 ‐ 2021

Alumni Directory

1992 ‐ 2021

Updated, 4/2021

The Richard and Susan Smith Family Foundation is committed to effecting permanent positive change in the lives of the residents of Greater Boston, particularly individuals and families in economically disadvantaged communities. Today, three generations of the Smith family oversee the Foundation, stewarding approximately $15 million annually in grants aimed at promoting greater health, educational attainment, and economic mobility. In the area of health, the Foundation supports the advancement of biomedical research and the expansion of access to high‐quality health care at safety net institutions serving low‐income individuals and communities of Greater Boston.

In 1991, the Smith Family Foundation contracted with The Medical Foundation at Health Resources in Action to create a grantmaking program that would identify and support promising junior faculty to find breakthroughs in such areas as AIDS/HIV, cancer, heart disease, diabetes or neuroscience. Since 2008, the Award has broadened to support newly independent faculty engaged in basic biomedical science as well as physics, chemistry and engineering with a focus on biomedicine. The Awards are currently in the amount of $300,000 over three years.

Over the past 30 years, the Smith Family Awards Program for Excellence in Biomedical Research has helped launch the careers of 181 outstanding scientists with support totaling $38.3 million.

The following is a listing of all Award Recipients in alphabetical order with current contact information as well as the title of the funded research project. The Smith Family is extraordinarily proud of the accomplishments of its Awardees and is honored to provide the critical support for their newly established research programs.

Cristina Aguayo‐Mazzucato, M.D., Ph.D. Jennifer Benanti, Ph.D. (2021 Award Recipient) (2011 Award Recipient) Targeting Beta‐Cell Senescence in Diabetes Mapping the Proteolytic Regulatory Network Joslin Diabetes Center that Controls Cell Division cristina.aguayo‐ University of Massachusetts Medical School [email protected] [email protected]

Judith Agudo, Ph.D. Leslie J. Berg, Ph.D. (2019 Award Recipient) (1993 Award Recipient) Novel platform to increase dendritic cell Analysis of the Tsk tyrosine Kinase in function and antigen‐specific T cell responses Transgenic Mice to cancer University of Massachusetts Medical School Dana‐Farber Cancer Institute [email protected] [email protected] Sudha Biddinger, M.D., Ph.D. Mark L. Andermann, Ph.D. (2010 Award Recipient) (2012 Award Recipient) Regulation of the LDLR by Insulin and Cortical Networks Guiding Hunger‐Dependent Diabetes Attention to Food Cues Boston Children's Hospital Beth Israel Deaconess Medical Center [email protected] [email protected] Jonathan S. Bogan, M.D. Zolt P. Arany, M.D., Ph.D. (2000 Award Recipient) (2008 Award Recipient) Role of ARF Proteins in GLUT4 Trafficking Peroxisome Proliferator‐Activated Receptor Yale School of Medicine Gamma 1alpha (PGC‐1alpha) and Cardiac [email protected] Angiogenesis University of Pennsylvania Laurie A. Boyer, Ph.D. [email protected] (2009 Award Recipient) Non‐coding RNA as a Regulator of Cell Fate Scott A. Armstrong, M.D., Ph.D. through Functional Interaction with Polycomb (2004 Award Recipient) Group Proteins Multi‐step Pathogenesis of MLL‐rearranged Massachusetts Institute of Technology Leukemias [email protected] Memorial Sloan‐Kettering Cancer Center [email protected] James E. Bradner, M.D. (2010 Award Recipient) Emily Patricia Balskus, Ph.D. Chemical Inhibition of Bromodomains in (2011 Award Recipient) Cancer Understanding and Preventing the Production Novartis Institutes of BioMedical Resaerch of Disease‐Associated Metabolites by the [email protected] Human Gut Microbiota Harvard University [email protected]

David K Breslow, Ph.D. Abhishek Chatterjee, Ph.D. (2018 Award Recipient) (2013 Award Recipient) Deconstructing the Cellular Antenna: Primary A Chemical Toolset to Investigate and Cilium Disassembly and Control of Cell Engineer Viral Infection Growth Boston College Yale University [email protected] [email protected] Iain M. Cheeseman, Ph.D. Alan Brown, Ph.D. (2007 Award Recipient) (2018 Award Recipient) Proteomic and Functional Dissection of the Structural Basis of Intraflagellar Transport Human Kinetochore Harvard Medical School Whitehead Institute for Biomedical Research [email protected] [email protected]

Jessica A Cardin, Ph.D. Jianzhu Chen, Ph.D. (2012 Award Recipient) (1995 Award Recipient) GABAergic Contributions to Neural and Molecular Analysis of Memory B Cell Cognitive Deficits in a Genetic Model of Differentiation Schizophrenia. Massachusetts Institute of Technology Yale University [email protected] [email protected] Jerry Lu Chen, Ph.D. William A. Carlezon, Ph.D. (2016 Award Recipient) (1999 Award Recipient) Circuit Mechanisms for Long‐Range Neural Substrates of Aversion to Addictive Communication in the Neocortex Drugs Boston University McLean Hospital jerry@chen‐lab.org [email protected] James Jeiwen Chou, Ph.D. Francis Ka‐Ming Chan, Ph.D. (2003 Award Recipient) (2003 Award Recipient) Structural Study of the Membrane‐Associated TNF‐Induced Programmed Cell Death in State of BID for Understanding BID‐Induced Immune Responses Damage of Mitochondrial Wall during University of Massachusetts Medical School Apoptosis [email protected] Harvard Medical School [email protected] Daniel L. Chase, Ph.D. (2006 Award Recipient) Damon Alistair Clark, Ph.D. Electrophysiological Analysis of Novel (2013 Award Recipient) Dopamine Signaling Mechanisms in C. Dissecting Motor Pattern Generating Circuits elegans in Walking Drosophila Central Connecticut State University Yale University [email protected] [email protected]

Steven Chuck, M.D. Alexei Degterev, Ph.D. (1997 Award Recipient) (2007 Award Recipient) Regulation of Apolipoprotein B Secretion Molecular Mechanism and Oncogenic Gilead Sciences Regulation of Cellular Necrosis [email protected] Tufts University School of Medicine [email protected] Andrew Connolly, M.D., Ph.D. (1998 Award Recipient) Walter E. Demkowicz, Ph.D. Endothelial Protease‐Activated Receptors (1995 Award Recipient) Stanford University School of Medicine Immunotherapy for AIDS: Transduction of [email protected] HIV‐1‐Specific T‐cell Receptor Genes University of Massachusetts Medical School Paul B. Cook, Ph.D. [email protected] (2000 Award Recipient) Modulation of Glycinergic Inhibition in the Li Deng, Ph.D. Vertebrate (1999 Award Recipient) Integrated Project Management A Chemical Approach Toward Understanding [email protected] DNA Modification Brandeis University David Daniel Cox, Ph.D. [email protected] (2013 Award Recipient) Learning How to See: a Biological and Stephanie Dougan, Ph.D. Computational Investigation of How Visual (2015 Award Recipient) Cortex Learns and Develops In Situ Delivery of Neoantigens and Targeted Harvard University Radiation in a Therapeutic Vaccine for [email protected] Pancreatic Cancer Dana‐Farber Cancer Institute Daniel H. Cox, Ph.D. [email protected] (2000 Award Recipient) Characterization of the Ca2+ Binding Sites of Elaine A. Elion, Ph.D. the Large‐Conductance Ca2+‐Activated K+ (1992 Award Recipient) Channel Mechanisms of Negative Growth Control in Tufts University School of Medicine Saccharomyces cerevisiae [email protected] Harvard Medical School [email protected] Michael Crickmore, Ph.D. (2015 Award Recipient) Patrick T. Ellinor, M.D., Ph.D. Molecular and Circuit Analyses of a (2003 Award Recipient) Motivational State The Genetics of Atrial Fibrillation: Exploration Boston Children’s Hospital of Endophenotypes [email protected] Massachusetts General Hospital [email protected]

Sean Elliott, Ph.D. Marc R. Freeman, Ph.D. (2004 Award Recipient) (2004 Award Recipient) Thioredoxins, Thioredoxin Reductase adn the Characterizing Core Components of the Glial Mechanisms of Oxidative Stress Cell Machinery Boston University University of Massachusetts Medical School [email protected] [email protected]

Patrick Emery, Ph.D. Lillian Fritz‐Laylin, Ph.D. (2002 Award Recipient) (2019 Award Recipient) Circadian Rhythms and their Synchronization Defining Mechanisms of Pathogenesis of the in Drosophila “Brain‐eating Amoeba” University of Massachusetts Medical School University of Massachusetts Amherst [email protected] [email protected]

Tamar Enoch, Ph.D. Robert C. Fuhlbrigge, M.D., Ph.D. (July 1993 Award Recipient) (1999 Award Recipient) Using Yeast to Identify New Tumor Regulation of CTCL Migration to Skin via CLA Suppressor Genes Brigham and Women's Hospital [email protected] Jerry Faust, Ph.D. (1992 Award Recipient) Jianmin Gao, Ph.D. Cloning and Initial Characterization of a Kidney (2007 Award Recipient) Specific Transporter for Mevalonic Acid Understanding Beta Sheet Structure within Tufts University School of Medicine the Membrane Bilayer [email protected] Boston College [email protected] Steven M. Finkbeiner, M.D., Ph.D. (1998 Award Recipient) Neil Joseph Ganem, Ph.D. Molecular Mechanisms of Huntington's (2014 Award Recipient) Disease Maintenance of Genome Stability by the Gladstone Institute of Neurological Disease Hippo Tumor Suppressor Pathway [email protected] Boston University School of Medicine [email protected] Matthew L. Freedman, M.D. (2006 Award Recipient) Timothy J. Gardner, Ph.D. A Genome‐Wide Admixture Scan to Identify (2009 Award Recipient) Genetic Determinants of Basal‐Like Breast Exploring the Function of Sleep in Neural Cancer Circuit Formation Dana‐Farber Cancer Institute Boston University [email protected] [email protected]

Ethan Clark Garner, Ph.D. Timothy E. Graham, M.D. (2012 Award Recipient) (2007 Award Recipient) Building a Mechanistic Understanding of Stimulated by Retinoic Acid‐6 (Stra6) and Bacterial Cell Wall Growth using High‐ Insulin Resistance Resolution Dynamic Imaging University of Utah School of Medicine Harvard University [email protected] [email protected] Nikolaus Grigorieff, M.Sc., Ph.D. Frank B. Gertler, Ph.D. (2000 Award Recipient) (1998 Award Recipient) Structural Analysis of the Shaker Potassium Mena Function in Tumor Cell Biology and Channel Metatasis Janelia Research Campus Massachusetts Institute of Technology [email protected] [email protected] Paul Lieberman Greer, Ph.D. Grace Gill, Ph.D. (2018 Award Recipient) (1996 Award Recipient) Exploring the Role of a Novel Population of Regulation of Cell Growth by Cellular EIA‐Like Microglia in Alzheimer's Disease Proteins University of Massachusetts Medical School Tufts University School of Medicine [email protected] [email protected] Steven R. Grossman, Ph.D., M.D. Lisa V. Goodrich, Ph.D. (2000 Award Recipient) (2003 Award Recipient) Purification and Analysis of a p53‐Targeted Cellular and Molecular Mechanisms of Ubiquitin Ligase Sensory System Development Virginia Commonwealth University Harvard Medical School [email protected] [email protected] Marc‐Jan Gubbels, Ph.D. Fotini Gounari, Ph.D., D.Sc. (2006 Award Recipient) (2003 Award Recipient) Dissection of Toxoplasma gondii Cell Division, Thymocyte Transformation in the DN to DP an Opportunistic Pathogen Causing Transition Myocarditis and Encephalitis University of Chicago Boston College [email protected] [email protected]

Yonatan Grad, M.D., Ph.D. Piyush Gupta, Ph.D. (2015 Award Recipient) (2011 Award Recipient) Genetic Networks of Antibiotic Resistance in Functional Dissection of Invasive Neisseria gonorrhoeae Mesenchymal Cancer Cells Harvard School of Public Health Whitehead Institute for Biomedical Research [email protected] [email protected]

Jeanne A. Hardy, Ph.D. Joel Hirschhorn, M.D., Ph.D. (2005 Award Recipient) (2002 Award Recipient) Designing Allosteric Switches in Caspases Comprehensive Evaluation of Reported University of Massachusetts Amherst Associations between Common Gene Variants [email protected] and Obesity" Boston Children's Hospital Aaron N. Hata, M.D., Ph.D. [email protected] (2017 Award Recipient) Determining the Impact of Therapy‐Induced Andreas Hochwagen, Ph.D. Mutations on Tumor Heterogeneity and (2007 Award Recipient) Evolution of Acquired Drug Resistance Investigating the Role of Checkpoint MGH Cancer Center Adaptation in Anti‐Cancer Drug Resistance [email protected] New York University [email protected] Akiko Hata, Ph.D. (2001 Award Recipient) Ya‐Chieh Hsu, Ph.D. Mechanisms of TGF‐ß Signal Transduction (2014 Award Recipient) University of California, San Francisco Investigation of How Cell Types from Diverse [email protected] Lineages Coordinate Changes and Behaviors during Regeneration Daniel N. Hebert, Ph.D. Harvard University (1998 Award Recipient) [email protected] Tyrosine Maturation and Degradation in Normal Melanocytes and Melanoma Cells Jianming Hu, M.D., Ph.D. University of Massachusetts Amherst (1999 Award Recipient) [email protected] Host Factors Required for Hepatitis B Virus Assembly and Replication Michael J. Higley, M.D., Ph.D. The Pennsylvania State University College of (2010 Award Recipient) Medicine Neuromodulation of Synaptic Transmission in [email protected] the Prefrontal Cortex Yale School of Medicine Paul Huang, M.D., Ph.D. [email protected] (1994 Award Recipient) Vascular Function in Nitric Oxide Synthase Philip W. Hinds, Ph.D. Mutant Mice (1993 Award Recipient) Massachusetts General Hospital The Retinoblastoma Protein Pathway in [email protected] Differentiation, Senescence and Cancer Tufts University, Sackler School Jun R. Huh, Ph.D. [email protected] (2013 Award Recipient) Bacterial Regulators of Immunity and their Modulation of Host Transcription Factors University of Massachusetts Medical School [email protected]

Craig P. Hunter, Ph.D. Aleksandar David Kostic, Ph.D. (1997 Award Recipient) (2016 Award Recipient) Identifying the Regulatory Targets of pal‐1 Immunological Investigation of Human Type Harvard University 1 Diabetes‐Associated Microbiomes in the [email protected] Gnotobiotic Autoimmune Diabetic Mouse Joslin Diabetes Center Tyler Jacks, Ph.D. [email protected] (1992 Award Recipient) Functional Analysis of the p53 Gene Philip J. Kranzusch, Ph.D. David H. Koch Institute for Integrative Cancer (2016 Award Recipient) Research at MIT Mechanism of Activation of a New Human [email protected] RNA Second Messenger Signaling Enzyme Dana‐Farber Cancer Institute Ankur Jain, Ph.D. [email protected] (2018 Award Recipient) Identifying Cellular Suppressors of RNA Jordan A. Kreidberg, M.D., Ph.D. Aggregation (1995 Award Recipient) Whitehead Institute for Biomedical Research A Transgenic Mouse Model of Wilms' Tumor [email protected] Boston Children's Hospital [email protected] James Jeanne, Ph.D. (2019 Award Recipient) Joshua Kritzer, Ph.D., M.Sc. Cracking the neural code for perception by (2009 Award Recipient) writing spikes into neural circuits Targeting Hsp90 with Small Cyclic Peptides Yale University Tufts University [email protected] [email protected]

David Jeruzalmi, Ph.D. Andrew Kruse, Ph.D. (2002 Award Recipient) (2015 Award Recipient) Structure and Function of Biological A New Approach to Targeting GPCRs Assemblies Harvard Medical School The City College of New York [email protected] [email protected] Galit Lahav, Ph.D. Karla R Kaun, Ph.D. (2005 Award Recipient) (2014 Award Recipient) p53 Dynamics and Control of Cell Fate Neuro‐molecular Mechanisms Underlying Harvard Medical School Alcoholism [email protected] Brown University [email protected]

David Lambright, Ph.D. Bernardo Lemos, Ph.D. (1996 Award Recipient) (2013 Award Recipient) Structural Determinants of G Protein Coupled Heterochromatin Variation, Bisphenol A Signal Transduction sensitivity, and Environmental Epigenomics University of Massachusetts Medical School Harvard School of Public Health [email protected] [email protected]

Matthew J. LaVoie, Ph.D. Anthony Letai, M.D., Ph.D. (2005 Award Recipient) (2004 Award Recipient) The Role of Protein Modification and Decoding BCL‐2 Family Interactions to Dysfunction in Parkinson's Disease Promote Cancer Cell Death Brigham and Women's Hospital Dana‐Farber Cancer Institute [email protected] [email protected]

Nathan D. Lawson, Ph.D. Michael Levin, Ph.D. (2003 Award Recipient) (2001 Award Recipient) Genetic Dissection of the Vascular Endothelial The Role of Katp ion Channels in Embryonic Growth Factor Signaling Pathway Development University of Massachusetts Medical School Tufts University [email protected] [email protected]

Michael Jungho Lee, Ph.D. Laura Lewis, Ph.D. (2014 Award Recipient) (2019 Award Recipient) Micro‐Environmental Regulation of Network Whole‐brain dopamine dynamics underlying State and Drug Sensitivity in Triple‐Negative sleep and wakefulness Breast Cancer Boston University University of Massachusetts Medical School [email protected] [email protected] Gene‐Wei Li, Ph.D. Sanghyun Lee, Ph.D. (2016 Award Recipient) (2021 Award Recipient) Breaking the Robustness of Bacterial A Focused Approach to Identify Entry Factors Translation for Pathogenic Enteric Viruses Using CRISPR Massachusetts Institute of Technology Activation Screening [email protected] Brown University [email protected] Rong Li, Ph.D. (1995 Award Recipient) Jacqueline A. Lees, Ph.D. The Role of Cdc42 in Actin Cytoskeleton (1995 Award Recipient) Assembly The Role of pRB and E2F in Tumorigenesis Stowers Institute for Medical Research Massachusetts Institute of Technology [email protected] [email protected]

Liang Liang, Ph.D. Joseph J. Loparo, Ph.D. (2021 Award Recipient) (2011 Award Recipient) Early Visual Centers Coordinate to Shape the Exploring the Molecular Mechanisms of Flow of Information Translesion DNA Synthesis through Single‐ Yale University Molecule Microscopy [email protected] Harvard Medical School [email protected] Maofu Liao, Ph.D. (2016 Award Recipient) Bradford B. Lowell, M.D., Ph.D. Cryo‐EM Studies of Multidrug Resistance (1994 Award Recipient) Conferred by Human ABC Transporters The B3‐Adrenergic Receptor: A Gene Harvard Medical School Knockout Analysis of Function [email protected] Beth Israel Deaconess Medical Center [email protected] Stuart Licht, Ph.D. (2002 Award Recipient) Gavin MacBeath, Ph.D. Interactions of Sulfonyluria Anti‐Diabetic (2002 Award Recipient) Agents with the ATP‐Sensitive Potassium Towards the System‐Wide Study of Channel Neuronally‐ Expressed PDZ Domains Sanofi‐Aventis Merrimack Pharmaceuticals stuart.licht@sanofi‐aventis.com [email protected]

Tami Lieberman, Ph.D. Sibongile Mafu, Ph.D. (2018 Award Recipient) (2018 Award Recipient) Determinants of Bacterial Colonization of Discovery and Mechanism of Plant‐Derived Facial Skin Antifungals Massachusetts Institute of Technology University of Massachusetts Amherst [email protected] [email protected]

Klaus Lindpaintner, M.D. Amity Lynn Manning, Ph.D. (1993 Award Recipient) (2017 Award Recipient) Molecular Genetics of Hypertension and Epigenetic Regulation of Mitotic Fidelity Stroke Worcester Polytechnic Institute Thermo Fisher Scientific [email protected] [email protected] Katherine M. Martien, M.D. Myra Lipes, M.D. (2000 Award Recipient) (1994 Award Recipient) The Efficacy of Valproic Acid in the Treatment A Transgenic Approach to the Study of of Autism Associated with Regression and/or Tolerance Induction in Type I Diabetes Severe Sleep Disturbance Joslin Diabetes Center LADDERS Clinic [email protected] [email protected]

Steven A. McCarroll, Ph.D. Martin G. Myers, M.D., Ph.D. (2010 Award Recipient) (1998 Award Recipient) Finding the Human Genome's Missing Pieces Molecular Determinants of Leptin Harvard Medical School Receptor/Jak2 Signaling [email protected] University of Michigan Medical School [email protected] Andrea I. McClatchey, Ph.D. (1999 Award Recipient) Sarah E. O'Connor, Ph.D. Identification of the Molecular Function of (2003 Award Recipient) the NF2 Tumor Suppressor, Merlin Human Biosynthesis of Alkaloids: Chemical Massachusetts General Hospital Inducers of Parkinson's Disease [email protected] The John Innes Center Sarah.O'[email protected] Kara Lavidge McKinley, Ph.D. (2021 Award Recipient) Jose Ordovas-Montanes, Ph.D. Molecular Mechanisms Underlying Uterine (2019 Award Recipient) Regeneration Inflammatory Memory and Adaptation in Harvard University Human Intestinal Epithelial Stem Cells [email protected] Boston Children’s Hospital Jose.Ordovas‐ David E. Moller, M.D. [email protected] (1992 Award Recipient) Molecular Genetic Analysis of Candidate P.O. Lauren Orefice, Ph.D. Genes for Insulin Resistance (2019 Award Recipient) Eli Lilly and Company Development, Function and Dysfunction of [email protected] Peripheral Sensory Neurons: Insights for Autism Spectrum Disorders Babak Momeni, Ph.D. Massachusetts General Hospital (2017 Award Recipient) [email protected] Elucidating the Molecular Mechanisms of Microbial Interactions Using Tn‐Seq Noah Wolcott Palm, Ph.D. Boston College (2016 Award Recipient) [email protected] A Universal Genetic Toolkit to Illuminate Host‐Microbiota Interactions Melissa J. Moore, Ph.D. Yale University (1994 Award Recipient) [email protected] Dynamics of Protein‐RNA Interaction in the Mammalian Spliceosome Suzanne Paradis, Ph.D. University of Massachusetts Medical School (2008 Award Recipient) [email protected] Dissecting the Function of Semaphorin 4B in Excitatory and Inhibitory Synapse Formation Brandeis University [email protected]

Sareh Parangi, M.D. Nicholas Rhind, Ph.D. (1999 Award Recipient) (2001 Award Recipient) Antiangiogenic Therapy, A Novel Therapy for The Role of Induced Recombination in the Pancreatic Cancer Fission Yeast S‐phase DNA Damage Massachusetts General Hospital Checkpoint [email protected] University of Massachusetts Medical School [email protected] Christopher L. Passaglia, Ph.D. (2005 Award Recipient) John Rinn, Ph.D. Retinal Coding of Visual Information in (2008 Award Recipient) Glaucomatous Eyes Large Intergenic Non‐Coding RNAs in Cancer University of South Florida Harvard University [email protected] [email protected]

R. Christopher Pierce, Ph.D. Tobias Ritter, Ph.D. (1999 Award Recipient) (2008 Award Recipient) Neurotrophins and Cocaine Addiction Approach to Access Positron‐Emission‐ University of Pennsylvania School of Tomography (PET) Tracers for Molecular Medicine Imaging [email protected] Harvard University [email protected] Emmanuel N. Pothos, Ph.D. (2002 Award Recipient) W. Benjamin Rogers, Ph.D. The Effects of Dietary Obesity on CNS Reward (2017 Award Recipient) Systems Developing DNA Nanotechnology Tools for Tufts University School of Medicine Probing RNA Secondary Structure and RNA‐ [email protected] Protein Interactions Brandeis University Sridhar Ramaswamy, M.D. [email protected] (2002 Award Recipient) Molecular Diagnostics for Cancer Metastasis Silvia Rouskin, Ph.D. Massachusetts General Hospital Cancer (2016 Award Recipient) Center Identifying the Factors Required for mRNA [email protected] Localization During Metazoan Development Whitehead Institute for Biomedical Research Peter W. Reddien, Ph.D. [email protected] (2006 Award Recipient) Regulation of Stem Cells for Regeneration in Sandra Ryeom, Ph.D. Planarians (2005 Award Recipient) Whitehead Institute for Biomedical Research Cancer Protection by the Down Syndrome [email protected] Candidate Region‐1 Gene University of Pennsylvania School of Medicine [email protected]

Bernardo L. Sabatini, M.D., Ph.D. Gavin R. Schnitzler, Ph.D. (2001 Award Recipient) (2000 Award Recipient) The Role of Regulated Protein Translation in Human Chromatin Remodeling Complexes Synapse Formation and Spine Growth and Transcriptional Control Harvard Medical School Tufts University School of Medicine [email protected] [email protected]

Adrian Salic, Ph.D. David C. Seldin, M.D., Ph.D. (2005 Award Recipient) (1996 Award Recipient) Chromosome Segregation in Vertebrates: A Casein Kinase II and Lymphomagenesis in Multidisciplinary Approach to Understanding Transgenic Mice Kinetochore Function and Centromeric Boston University Medical Center Cohesion Harvard Medical School Piali Sengupta, Ph.D. [email protected] (1997 Award Recipient) Role of Nuclear Receptors in the Susan L. Santangelo, Sc.D. Chemosensory System of C. elegans (July 1997 Award Recipient) Brandeis University Extremely Discordant Sib‐Pairs to Search for [email protected] Autism Genes Massachusetts General Hospital Matthew D. Shair, Ph.D. [email protected] (1997 Award Recipient) Discovery of Small Molecules which Disrupt Rebecca A Scheck, Ph.D. Protein‐Protein Interactions (2014 Award Recipient) Harvard University Mapping the Uncharted: Encodable [email protected] Chemistry to Discover the Role of Glycation in Disease Sichen Shao, Ph.D. Tufts University (2017 Award Recipient) [email protected] Mechanistic Dissection of Tail‐Anchored Membrane Protein Sorting Gabriela Schlau‐Cohen, Ph.D. Harvard Medical School (2015 Award Recipient) [email protected] A Biophysical Toolkit to Explore Bacteria Chemotaxis Ann M. Sheehy, Ph.D. Massachusetts Institute of Technology (2007 Award Recipient) [email protected] Harnessing the Power of the Anti‐HIV Protein APOBEC3G Dietmar Schmucker, Ph.D. College of the Holy Cross (2001 Award Recipient) [email protected] Function of the Molecular Diversity of Neuronal Receptors VIB Vesalius Research Center dietmar.schmucker@vib‐kuleuven.be

Michael Y. Sherman, Ph.D. Kimberly Stegmaier, M.D. (1996 Award Recipient) (2007 Award Recipient) Molecular Chaperones and Degradation of Chemical Genomic Approach to Modulating Oxidatively Damaged Proteins Oncogenic Transcription Factors Boston University School of Medicine Dana‐Farber Cancer Institute [email protected] [email protected]

Ramesh A. Shivdasani, M.D., Ph.D. Beth Stevens, Ph.D. (1997 Award Recipient) (2008 Award Recipient) Identification and Characterization of Genes The Role of the Complement Cascade in that Regulate Vertebrate Gut Epithelial Cell Eliminating Synapses during Development Differentiation and Disease Dana‐Farber Cancer Institute Boston Children's Hospital [email protected] [email protected]

Matthew Donald Shoulders, Ph.D. Radhika Subramanian, Ph.D. (2013 Award Recipient) (2015 Award Recipient) Hijacking the Host Cell's Protein Homeostasis Building a Cilium for Intercellular Signaling in Network to Potentiate Viral Evolution Vitro Reconstitution of the Hedgehog Massachusetts Institute of Technology Signaling Pathway [email protected] Massachusetts General Hospital [email protected] Sergei Y. Sokol, Ph.D. (1994 Award Recipient) Masahiko Sugita, M.D. The Dishevelled Gene Product and the (2000 Award Recipient) Establishment of Dorso‐Ventral Polarity in A Novel Pathway for Lipid Antigen Xenopus Embryos Presentation by CD1 Molecules Mount Sinai School of Medicine Kyoto University [email protected] [email protected]‐u.ac.jp

Bryan Spring, Ph.D. Elsie M. Sunderland, Ph.D. (2017 Award Recipient) (2012 Award Recipient) Peering into Cancer Stem Cell Niches to Guide Sources, Trends and Effects of Immunotoxic Suppression of Multiple Signaling Loop Perfluorinated Compounds Pathways Harvard School of Public Health Northeastern University [email protected] [email protected] Mario Luca Suva, M.D., Ph.D. Mansi Srivastava, Ph.D. (2014 Award Recipient) (2016 Award Recipient) Uncovering the Role of Epigenetic Cellular Dynamics and Regulation of Programs in Glioblastoma Pluripotent Stem Cells in vivo Massachusetts General Hospital Harvard University [email protected] [email protected]

Sam Thiagalingam, Ph.D. Gowthaman Uthaman, Ph.D. (2000 Award Recipient) (2021 Award Recipient) hBUB1, an Alternate Target for p53 Regulation of Anaphylactic IgE Promoting Inactivation Tfh13 Cell Subset in Allergic Sensitization Boston University School of Medicine University of Massachusetts Medical School [email protected] [email protected]

Stefan Thor, Ph.D. Sander van den Heuvel, Ph.D. (2000 Award Recipient) (1998 Award Recipient) Specification of Neuronal Cell Identities Genetic Analysis of Cell‐Cycle Regulation and during Drosophila Embryogenesis Checkpoint Control Linköping University Utrecht University [email protected] [email protected]

Alex Toker, Ph.D. David Van Vactor, Ph.D. (1998 Award Recipient) (1997 Award Recipient) The Role of Protein Kinase C in Integrin‐ Molecular Analysis of Fastlane, a Novel Gene Mediated Tumor Invasion Required for Specific Axon Guidance Beth Israel Deaconess Medical Center Harvard Medical School [email protected] [email protected]

Eduardo M. Torres, Ph.D. Matthew G. Vander Heiden, M.D., Ph.D. (2012 Award Recipient) (2010 Award Recipient) Role of Protein Turnover Pathways in The Impact of Pyruvate Kinase Activity on Aneuploid Cells Cancer Cell Metabolism and Tumor Growth In University of Massachusetts Medical School Vivo [email protected] Massachusetts Institute of Technology [email protected] Shannon J. Turley, Ph.D. (2005 Award Recipient) Shobha Vasudevan, Ph.D. Targeting IkappaB Kinase in Dendritic Cells to (2010 Award Recipient) Prevent Pancreatic Cancer Regulation of Quiescence by MicroRNAs Genentech Massachusetts General Hospital [email protected] [email protected]

Naoshige Uchida, Ph.D. Douglas E. Vetter, Ph.D. (2007 Award Recipient) (2001 Award Recipient) Elucidating Neural Circuits Underlying A Transgenic and Proteomic Analysis of Decision‐Making in Rodents Olivocochlear System Function and Harvard University Development [email protected] The University of Mississippi Medical Center [email protected]

Seychelle M. Vos, Ph.D. Eranthie Weerapana, Ph.D. (2021 Award Recipient) (2011 Award Recipient) Elucidating How Genome Organization Activity‐Based Proteomic Approaches to Influences Gene Expression Investigate Aging in C. Elegans Massachusetts Institute of Technology Boston College [email protected] [email protected]

Amy J. Wagers, Ph.D. Kristin White, Ph.D. (2004 Award Recipient) (1996 Award Recipient) Intrinsic and Extrinsic Regulators of Genetic Control of Apoptosis in Drosophila Hematopoietic Stem Cell Function Massachusetts General Hospital Joslin Diabetes Center [email protected] [email protected] Jessica LaMae Whited, Ph.D. Yong‐Xu Wang, Ph.D. (2013 Award Recipient) (2006 Award Recipient) Understanding Information‐Encoding During Transcriptional Control of Hepatic Salamander Limb Regeneration Gluconeogenesis by Twist‐1 Brigham and Women's Hospital University of Massachusetts Medical School [email protected] [email protected] Rachel I. Wilson, Ph.D. Hongwei Wang, Ph.D. (2004 Award Recipient) (2009 Award Recipient) Synaptic Mechanisms of Chemical Stimulus Structure and Mechanism of the Human RISC‐ Encoding Loading Complex Harvard Medical School Yale University [email protected] [email protected] Florian Winau, M.D. Steven Warach, M.D., Ph.D. (2009 Award Recipient) (1993 Award Recipient) Hepatic Stellate Cells Instruct Lymphoid Distinguishing Reversible from Irreversible Progenitors to Home to the Thymus Ischemic Neuronal Injury Immune Disease Institute Seton/UT Southwestern Medical Center [email protected] [email protected] Yong Xiong, Ph.D. H. Christian Weber, M.D. (2006 Award Recipient) (1999 Award Recipient) Mechanisms of HIV Suppression by Human Human Gastrin‐Releasing Peptide Receptor Antiviral Protein APOBEC3G and HIV's Gene Regulation Countermeasures Boston University School of Medicine Yale University [email protected] [email protected]

Lee Zou, Ph.D. (2004 Award Recipient) Sensing and Signaling DNA Damage in Human Cells Massachusetts General Hospital [email protected]