Distilled Spirits of the World
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Identification of the Enzymatic Mechanism of Nitroglycerin Bioactivation
Identification of the enzymatic mechanism of nitroglycerin bioactivation Zhiqiang Chen*†, Jian Zhang†, and Jonathan S. Stamler*†‡§ *Howard Hughes Medical Institute, Departments of †Medicine and §Biochemistry, Duke University Medical Center, Durham, NC 27710 Communicated by Irwin Fridovich, Duke University Medical Center, Durham, NC, April 15, 2002 (received for review March 26, 2002) Nitroglycerin (glyceryl trinitrate, GTN), originally manufactured by synthesized according to ref. 17 and purified by TLC. 1,2-GDN Alfred Nobel, has been used to treat angina and heart failure for and 1,3-GDN was prepared by hydrolysis of GTN and purified over 130 years. However, the molecular mechanism of GTN bio- by TLC (18). [2-14C] GTN (55 mCi͞mmol) was obtained from transformation has remained a mystery and it is not well under- American Radiolabeled Chemicals (St. Louis). Disulfiram, chlo- stood why ‘‘tolerance’’ (i.e., loss of clinical efficacy) manifests over ral hydrate, cyanamide, acetaldehyde, phenylephrine, sodium time. Here we purify a nitrate reductase that specifically catalyzes nitroprusside (SNP), Q-Sepharose, DEAE-cellulose, and butyl- the formation of 1,2-glyceryl dinitrate and nitrite from GTN, lead- Sepharose were obtained from Sigma. Hydroxyapatite and ing to production of cGMP and relaxation of vascular smooth protease inhibitor (mixture set III) were from CalBiochem. muscle both in vitro and in vivo, and we identify it as mitochondrial The cGMP assay (125I) kit was purchased from Amersham aldehyde dehydrogenase (mtALDH). We also show that mtALDH is Pharmacia. inhibited in blood vessels made tolerant by GTN. These results demonstrate that the biotransformation of GTN occurs predomi- Enzyme Purification. Mouse RAW264.7 cells (50-g pellet; Ϸ1010 nantly in mitochondria through a novel reductase action of cells) were disrupted by sonication in 30 mM phosphate buffer mtALDH and suggest that nitrite is an obligate intermediate in (KPi), pH 7.5 containing 1 mM DTT, 0.5 mM EDTA, and generation of NO bioactivity. -
Artisan Producers Offer a Voyage of Discovery
COGNAC Artisan producers ognac’s history and reputation are unrivaled among spirits. But despite associations with celebrities, elitism, luxury and opulence, at the end of the day Cognac is about dirt, grapes and a series of offer a voyage of organic reactions. The mysterious yet simple ritual of its cre- Cation—from harvest and crush to fermentation, distillation, élevage and bot- discovery tling—yields one of the most ethereal spirits ever known. Because of the recent rise in artisanal Cognac—an extension of the global craft-spirits movement—we have been able to re-examine brandy By Wyatt Peabody as a whole. And, thanks to the tireless work of a few determined import- ers, today we have access to small producers, most of which were all but unknown in the United States previously. San Francisco importer Charles Much of the wine made from Neal first introduced Dudognon Cognac in 1998. In the years since, Neal these vineyards around St.-Preuil in western France will be distilled has gone on to work with dozens of independent producers throughout and aged into Cognac. the Cognac region. DEC. 15, 2014 • WINE SPECTATOR 107 “Cognac has always been about terroir,” pro- claims Neal, who was brazen enough to start importing artisanal Cognac before people knew anything other than what the big four—Hen- nessy, Rémy Martin, Courvoisier and Martell— were selling. So how does one disrupt a seem- ingly impenetrable market, some 80 percent of which is controlled by four companies? For an enophile like Neal, it was by focusing on the winelike, site-specific nature of Cognac. -
Coffees & Such Dessert Wine Porto Cognac Armagnac
COFFEES & SUCH DESSERTS VIETNAMESE COFFEE 3.25 $8 CAFÉ DU MONDE CHICORY BLEND, FILTER-DRIPPED APPETIZERS OVER SWEETENED CONDENSED MILK PASSION FRUIT ENTREMET METROPOLIS COFFEE 2.50 PASSION FRUIT, BAVARIAN CREAM AND DARK CHOCOLATE MOUSSE CAPPUCCINO 3.50 ON A BED OF VANILLA CAKE WITH A CHOCOLATE GLAZE CAFÉ AU LAIT 3.00 BANANA TAPIOCA PUDDING ESPRESSO 3.00 WARM TAPIOCA, COCONUT MILK & BANANAS, TEAS-RISHI, ORGANIC & FAIR TRADE CERTIFIED TOPPED WITH TOASTED SESAME SEEDS PLEASE ASK YOUR SERVER FOR SELECTIONS 3.75 CARAMELIZED LEMON TART DESSERT WINE CUSTARD LEMON TART, WITH A SHORTBREAD CRUST BRICCO RIELLA MOSCATO D’ASTI, 2014; PIEDMONT, ITALY 7.00 CHOCOLATE MOUSSE CAKE CHÂTEAU DE ARCHE SAUTERNES GRAND CRU CLASSE, 2006 18.00 LAYERS OF CHOCOLATE CAKE & MOUSSE, PORTO WITH CRÈME ANGLAISE & SWISS RASPBERRY SAUCE GRAHAM’S “SIX GRAPES” RESERVE PORT 11.00 CRÈME BRÛLÉE QUINTA DO NOVAL “NOVAL BLACK” PORT 10.00 CLASSIC PRESENTATION, WITH VANILLA SEED TAYLOR FLADGATE 20 YEAR OLD TAWNY 18.00 CRISPY BANANA WONTON WARRE’S OTIMA 10 YEAR OLD TAWNY 15.00 WITH CRÈME ANGLAISE & DARK CHOCOLATE SAUCE COGNAC FRESH FRUIT SORBETS A.E. DOR RARE FINE CHAMPAGNE, VSOP 16.00 TWO SCOOPS OF SORBET; COURVOISIER, VSOP 14.00 LEMON, MANGO, RASBERRY OR BLOOD ORANGE HENNESSY, VSOP 15.00 GOURMET GELATOS HENNESSY, XO 30.00 TWO SCOOPS OF GELATO; REMY MARTIN, VSOP 12.00 CHOCOLATE OR VANILLA BEAN REMY MARTIN, XO 25.00 LE COLONIAL MACAROON ARMAGNAC VANILLA ICE CREAM IN A COCONUT MACAROON SHELL, LARRESINGLE, VSOP 11.00 DRIZZLED WITH DARK CHOCOLATE SAUCE CALVADOS MANGO SUNDAE BUSNEL, VSOP -
Addendum CSS 2021
Addendum regarding: The 2021 Certified Specialist of Spirits Study Guide, as published by the Society of Wine Educators Note: This document outlines the substantive changes to the 2021 Study Guide as compared to the 2020 version of the CSW Study Guide. All page numbers reference the 2020 version. Please note that in addition to the information noted below, the tables concerning top-selling brands of particular types of spirits have been updated to reflect the most current statistics available. Page 10: The information regarding congeners was expanded to include the following: Congeners: The preceding explanation of distillation has been simplified by using the example of a solution made of only ethyl alcohol and water. However, many other compounds are created during fermentation and as a result, there are other compounds besides water and alcohol present in a fermented solution. Known as congeners, these compounds are responsible for much of the aroma and flavor—besides that of pure ethyl alcohol and water—of a fermented beverage or a distilled spirit. Specific congeners include the various acids, esters, aldehydes, fusel oils, and alcohols (other than ethanol) that are developed during fermentation. During distillation, congeners may vaporize and blend in with the ethanol–water vapors; however, each specific congener will react differently based on three factors: boiling point, solubility (in ethanol and water), and specific gravity. In addition, the heat of the distillation process—via a series of chemical changes known as pyrolysis—may cause some compounds to change form, creating new and different congeners that may be passed onto the finished product. -
Criteria of Determination of Age of Cognac Spirits O
UDC 663.241:674.4/8 © 2016 Criteria of determination of age of cognac spirits O. Lukanin, academician of the NAAS, doctor of technical sciences Winemaking primary resources monitoring laboratory O. Sydorenko, Candidate of Technical Sciences Limited Liability Company «Pioner Noviishykh Tekhnolohii» The purpose. To develop criteria of estimation of ripeness of ordinary cognac spirits on the basis of measurements of concentration of basic aromatic components of oak which pass in spirit at seasoning in a barrel for 1 — 5 years. Methods. Experimental seasoning of cognac spirits in new barrels made from domestic oak was spent in industrial conditions. The equation of an index of age of cognac spirits is deduced by means of programs of statistical analysis of data. Concentration of aromatic components of an oak in cognac spirits was measured by chromatographic method. Results. The formula on which it is possible to calculate an index of age of cognac or cognac spirit up to 98,68% is developed. Conclusions. The criterion of estimation of ripeness of ordinary cognac spirits on the basis of measurements of concentration of basic components of oak which pass during seasoning in barrels for 1 — 5 years is offered. Key words: cognac spirits, aromatic components, classification, time of seasoning. Free Trade Zone Agreement of Ukraine with the EU, which has come into force on January 01st, 2016, is aimed at reducing and abolishing of tariffs for goods, as well as bringing the Ukrainian business rules and regulations into compliance with the EU rules and regulations in order to ensure free movement of goods and services and mutual non-discriminatory attitude towards companies within the territory of Ukraine and the EU. -
Cognac / Armagnac Calvados Aperitif & Digestif & Amaro
COGNAC / ARMAGNAC COMTES FILLES 18yr, PETITE CHAMPAGNE 40 PAUL BEAU, VS COGNAC 17 PAUL BEAU 15YR, VSOP COGNAC 22 PAUL BEAU HORS D’AGE 30YR 52 JACKY NAVARRE, VIEILLE RÉSERVE, 1ER CRU COGNAC 65 CH. LEBERON 1987 ARMAGNAC TÉNARÈZE 85 CH. LEBERON SOLERA ARMAGNAC TÉNARÈZE 2001 35 DOM. D’AURENSAN 20 ANS, ARMAGNAC TÉNARÈZE 56 DOM. D’ESPERANCE 1999, BAS ARMAGNAC 35 DOM. L’ENCANTADA 1987, BAS ARMAGNAC 65 SPIRITS DOM. L’ENCANTADA 1993, BAS ARMAGNAC 65 DOM. RAVIGNAN BAS ARMAGNAC 1983 65 DOM. RAVIGNAN BAS ARMAGNAC 2008 28 PELLEHAUT 5YR, ARMAGNAC TÉNARÈZE 16 CALVADOS ADRIEN CAMUT 6 ANS 25 ADRIEN CAMUT 12 ANS 35 ADRIEN CAMUT 18 ANS ‘PRIVILÈGE’ 45 ADRIEN CAMUT 25 ANS ‘RÉSERVE DE SEMAINVILLE’ 60 JULIEN FREMONT, NV 18 ROGER GROULT 12 ANS 30 ROGER GROULT 18 ANS 40 ROGER GROULT 25 ANS 60 ROGER GROULT ‘KRIEK’ 35 ROGER GROULT ‘JURANCON’ 45 APERITIF & DIGESTIF & AMARO AVERNA 12 ABANO 12 BONAL 12 BRAULIO 12 CHARTREUSE JAUNE 18 CHARTREUSE JAUNE VEP 42 CHARTREUSE VERTE 18 CHARTREUSE VERTE VEP 42 CYNAR 12 FERNET BRANCA 12 FORTHAVE MARSEILLE 18 FORTHAVE RED APERTIVO 14 LOUIS ROQUE LA VIELLE PRUNE 15 MONTENEGRO 12 MULASSANO BIANCO 15 NONINO 14 SIBELLA 12 VERGANO CHINATO 16 VERGANO LULI 16 VICARIO NOCINO 15 VODKA BOURBON TITOS 14 1792 FULL PROOF 18 BASIL HAYDEN’S 23 GIN BLANTONS 24 16 LONDON DRY BATCH#2 17 ELIJAH CRAIG 10YR 16 FORTHAVE BLUE 14 MICHTER’S BOURBON 28 GREENHOOK OLD TOM 16 OLD WELLER 107 ANTIQUE 22 HIGHBORN 14 RUSSELS RESERVE BOURBON 10YR 16 MONKEY 47 22 WILD TURKEY BOURBON 101 24 NEVERSINK 16 WILD TURKEY RARE SIPSMITHS LONDON DRY 14 TANQUERAY 14 RYE PETIT -
Computer Simulation Applied to Studying Continuous Spirit Distillation and Product Quality Control
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Food Control 22 (2011) 1592e1603 Contents lists available at ScienceDirect Food Control journal homepage: www.elsevier.com/locate/foodcont Computer simulation applied to studying continuous spirit distillation and product quality control Fabio R.M. Batista, Antonio J.A. Meirelles* Laboratory EXTRAE, Department of Food Engineering, Faculty of Food Engineering, University of Campinas e UNICAMP, Campinas, Brazil article info abstract Article history: This work aims to study continuous spirit distillation by computational simulation, presenting some Received 7 June 2010 strategies of process control to regulate the volatile content. The commercial simulator Aspen (Plus and Received in revised form dynamics) was selected. A standard solution containing ethanol, water and 10 minor components rep- 2 March 2011 resented the wine to be distilled. A careful investigation of the vaporeliquid equilibrium was performed Accepted 8 March 2011 for the simulation of two different industrial plants. The simulation procedure was validated against experimental results collected from an industrial plant for bioethanol distillation. The simulations were Keywords: conducted with and without the presence of a degassing system, in order to evaluate the efficiency of Spirits fi Distillation this system in the control of the volatile content. To improve the ef ciency of the degassing system, fl Simulation a control loop based on a feedback controller was developed. The results showed that re ux ratio and Aspen Plus product flow rate have an important influence on the spirit composition. High reflux ratios and spirit Degassing flow rates allow for better control of spirit contamination. -
Building a Home Distillation Apparatus
BUILDING A HOME DISTILLATION APPARATUS A Step by Step Guide Building a Home Distillation Apparatus i BUILDING A HOME DISTILLATION APPARATUS Foreword The pages that follow contain a step-by-step guide to building a relatively sophisticated distillation apparatus from commonly available materials, using simple tools, and at a cost of under $100 USD. The information contained on this site is directed at anyone who may want to know more about the subject: students, hobbyists, tinkers, pure water enthusiasts, survivors, the curious, and perhaps even amateur wine and beer makers. Designing and building this apparatus is the only subject of this manual. You will find that it confines itself solely to those areas. It does not enter into the domains of fermentation, recipes for making mash, beer, wine or any other spirits. These areas are covered in detail in other readily available books and numerous web sites. The site contains two separate design plans for the stills. And while both can be used for a number of distillation tasks, it should be recognized that their designs have been optimized for the task of separating ethyl alcohol from a water-based mixture. Having said that, remember that the real purpose of this site is to educate and inform those of you who are interested in this subject. It is not to be construed in any fashion as an encouragement to break the law. If you believe the law is incorrect, please take the time to contact your representatives in government, cast your vote at the polls, write newsletters to the media, and in general, try to make the changes in a legal and democratic manner. -
Vermont 802Spirits Current Complete Price List September 2021 1 of 24
Vermont 802Spirits Current Complete Price List September 2021 VT REG NH VT Sale Price Code Brand Size Price Price Price Save Proof Status per OZ Brandy Brandy Domestic 056308 Allen's Coffee Brandy 1.75L 19.99 15.99 17.99 2.00 70 High Volume 0.30 056306 Allen's Coffee Brandy 750ML 9.99 7.99 60 High Volume 0.39 056310 Allen's Cold Brew Coffee Brandy 750ML 14.99 60 New 0.59 052374 Coronet VSQ Brandy 375ML 4.99 80 High Volume 0.39 052584 E & J Superior Res. VSOP 1.75L 25.99 23.99 80 High Volume 0.44 052581 E & J Superior Res. VSOP 375ML 5.99 5.49 80 High Volume 0.47 052582 E & J Superior Res. VSOP 750ML 14.99 12.99 12.99 2.00 80 High Volume 0.51 052598 E & J VS Brandy 1.75L 24.99 21.99 22.99 2.00 80 High Volume 0.39 052596 E & J VS Brandy 750ML 12.99 11.99 80 High Volume 0.51 052563 E & J XO Brandy 750ML 16.99 15.99 80 High Volume 0.67 073864 E&J Spiced Brandy 750ML 9.99 60 New 0.39 053536 Laird's Applejack 750ML 17.99 15.99 80 High Volume 0.71 054916 Leroux Jezynowka Blackberry Brandy 750ML 11.99 8.99 70 Medium Volume 0.47 900488 Mad Apple Brandy 750ML 46.99 84 Medium Volume 1.85 054438 Mr. Boston Apricot Brandy 1.75L 17.99 13.99 70 High Volume 0.30 054436 Mr. -
Alcohol Hangover- Its Effects on Human Body: Review
DOI: 10.26717/BJSTR.2018.04.001112 Loveleen Bajaj. Biomed J Sci & Tech Res ISSN: 2574-1241 Mini Review Open Access Alcohol Hangover- its Effects on Human Body: Review Loveleen Bajaj* and Ranjeet Singh Department of Food science & technology, Khalsa College, India Received: May 20 2018; Published: May 25, 2018 *Corresponding author: Loveleen Bajaj, Department of Food science & technology, Khalsa College, Amritsar, India Abstract A hangover is a syndrome of physical and mental symptoms that occurs after 8 to 16 hours of consumption with a zero level of alcohol. The objective of the study is to explore effects of the alcohol hangover. The impairing effects on memory functioning such as delayed recall, response to battle infection leading to unpleasant effects include nausea, vomiting, dizziness, fatigue and hormonal imbalance in the body. Dehydrationirritation, lack is ofbelieved concentration to be the and cause after ofacute hangover alcohol as intoxication. it leads to anti-diuresisNormally the state body in might the body.use cytokines The most to compelling trigger fever theory of inflammatory that, at the moment, is that hangover results from a buildup of acetaldehyde, a toxic compound in the body. The congener amount in the particular alcoholic beverage is believed to be increase the extent of severity of hangover. Methanol, found in highest levels in whiskey and red wine has received a larger amount of blame for showing that it can linger in the body after all alcohol has been eliminated, perhaps accounting for the enduring effects of hangover. Abbreviations: BAC: Blood Alcohol Concentration; AW: Alcohol Withdrawal; FASD: Fetal Alcohol Spectrum Disorders Introduction Anes and colleagues revealed that half of the interrogated workers during hangover were at the work. -
Chapter 9 Cognac and Armagnac
Chapter 9 Cognac and Armagnac In This Chapter ▶ Finding out where cognac and armagnac are made ▶ Deciphering the designations on labels ▶ Getting familiar with the well-known brands ▶ Finishing a meal with a warm drink rance produces two kinds of brandy: cognac and armagnac. FBoth are named after the region in which they’re made, and both are delicious. Cognac Cognac can be produced only in the legally defined region of Cognac, France, located between the Atlantic and Massif Central — specifically, at the junction between the oceanic and continental climate zones. The region also straddles the dividing line between northern and southern climates. These four influences create a multitude of microclimates. In addition to the unique climate, the soil characteristics also foster a range of wine and, consequently, the cognac of each region. In 1909, the French government passed a law that only brandy produced in the “delimited area” surrounding the town of Cognac can be called cognac. How cognac is made The arduous, time-honored distilling and aging process is what makes cognac so special. The cognac you drink today was produced using methods dating back to the 17th century. The distillation of cognac is a two-stage process: 14_633120-ch09.indd 6914_633120-ch09.indd 69 7/26/10 10:50 AM7/26/10 10:50 AM 70 Part II: Short Shots from American Whiskey to Wine 1. A first distillate, known as brouillis, is obtained, with an alcoholic strength of 28 to 32 percent. 2. The brouillis is returned to the boiler for a second heating, which produces a liquid known as la bonne chauffe. -
Coffee Organic Tea Dessert Wines Dessert Fortified
DESSERT COFFEE BANANA WONTON Coffee 3.00 passion fruit cream, lychee sorbet, mint leaf 10.00 Espresso 3.25 FUJI TATIN Cappuccino 4.25 roasted fuji apple tart, calvados reduction 10.00 MANGO “TOFU” PUDDING ORGANIC TEA coconut coulis 11.00 6. small pot (1-2 people) 10. large pot (2-4 people) WARM BROWNIE Earl Grey green tea chantilly creme 10.00 an unusual spin on a classic, this black tea has creamy notes with bergamot. SEASONAL EXOTIC FRUIT PLATE 18.00 Meridian Chai TARTUFO bold and spicy, this aromatic blend celebrates precious spices that have been traded for centuries. green tea & red bean 10.00 Chaling Jasmin SORBET organic whole leaf tea with fresh jasmin blossoms for a blissfully sweet cup. mango, lychee, raspberry 10.00 Three Rivers TOKUI ICE CREAM grown high in the yunnan mountains, it yields a mild nutty flavor with subtle fruit undertones. choice of three scoops 10.00 vanilla, chocolate, green tea, ginger, black sesame or red bean Royal passion smooth rich blend infused with lightly tart tropical notes of luscious passion fruit. ASSORTED MOCHI ICE CREAM 11.00 White Lotus white tea leaves blended with soft citrus notes of lemon myrtle and zesty notes of ginger. FORTIFIED WINES / PORT glass / bottle Iron Goddess RAMOS PINTO “The Collector” 9. / 60. spring flush organic oolong leaves yield a silky cup of tea with notes of honeysuckle TAYLOR FLADGATE 10 year Tawny 10. / 75. Chamomile Yuzu FONSECA 20 year Tawny 18. / 140. a full spectrum of citrus flavors, layered with herbal infusion and softened by elderflower QUINTA DO VESUVIO 2012 20.